AP Biology Cell Membrane Transport and Cell Signaling Webquest part 2
Friday, 11/14/2014
Name____________________________
Directions for today in class:
Please watch the animations and videos that I have listed below, then after
watching them, attempt to answer the questions written below AND any
questions/self-quizzes at the website. Note that most of the McGraw Hill
animations are followed by a self-check set of multiple choice questions. I will
not collect this sheet, so I trust you to write as little as much as you like while
you watch. You can type the answers or handwrite. The key is that you should
follow the study practices that are best suited for your own learning style.
Please complete this webquest prior to our next class on Monday, 11/17. This
information will be included in the Cell membrane transport and signaling test on
Tuesday, 11/18. Some of the animations are not exciting—especially the
Biologix videos, but I have only attached resources that I KNOW are excellent
learning tools. In fact, the boring Biologix videos are some of the best
multimedia resources we have in AP Bio.
Learning goals:
I can describe the events that occur to allow a hormone to elicit a particular
response from a cell having a matching G-protein linked receptor protein on its
plasma membrane.
I can understand the roles of active & passive transport & cell signaling during
action potentials of neurons and during contractions of skeletal muscle cells.
I can understand the process of paracrine signaling that is used by helper T
lymphocytes during activation of cytotoxic T lymphocytes and B lymphocytes.
I can explain the events of the 3 stages of cell signaling that occur during any
receptor mediated cell response, and I can describe the roles of : 1st
messengers, receptor proteins, G proteins, second messengers, Protein kinase
C and signal transducing kinases, phosphatases, and effector molecules.
I can describe the relationship of 2 pairs of mammal endocrine system
hormones within negative feedback loops.
Intercellular communication
Signal transduction
www.masteringbiology.com
username nadinebrown567
password 1conceptualchemistry1
go to chapter 5
run the investigation—how do cell’s communicate with each other. If needed, run it
twice. You don’t have to write anything down in the lab notebook entrees, but you can
if you wish. Summarize your learning.
Run the lab bench: osmosis and diffusion. Summarize your learning. What is a dialysis
bag? How was this experiment similar to our investigation of potato osmosis? How
was it different?
Stay at www.masteringbiology.com go to chapter 37. Run the bioflix, Homeostasis:
Regulating sugar. Summarize what you learned. Make a diagram to show the
relationship of the two hormones in a negative feedback loop if you can.
Stay at www.masteringbiology.com and stay with chapter 37. Run the activities
nervous tissue, peptide hormone action, and steroid hormone action. Summarize your
learning from each animation.
Stay at www.masteringbiology.com , but move to chapter 35, the immune system.
Run the activity, the immune response—twice or more! Summarize and diagram your
understanding of how signals between antigen presenting cells, T helper cells, and
memory T and B cells leads to the specific cellular and humoral immune response.
Stay at www.masteringbiology.com and stay with chapter 39. Run the bioflix muscle
contraction and summarize your learning. Focus on the sequence of signaling—
reception, signal transduction, and response, as well as changes in arrangement of
actin and myosin relative to hydrolysis of ATP and presence of the second messenger,
Calcium ion.
Run the activity Skeletal muscle structure and the activity muscle contraction.
Summarize any additional learning about the sequence events that starts with binding
of acetylcholine and ends with enzymatic destruction of acetylcholine.
http://www.wiley.com/college/pratt/0471393878/instructor/animations/signal_trans
duction/index.html
Watch twice. Then, summarize:
General steps of all signal pathways
What is the role of kinases? Of phosphatases?
General steps of G protein signaling
What is the role of the receptor protein?
What is the role of the G protein?
What is the role of the PKC?
What is the role of cAMP?
What are the two ways that the signal is modified?
http://www.wiley.com/college/boyer/0470003790/animations/signal_transduct
ion/signal_transduction.htm
This animation is an excellent tutorial on the steps of G-protein mediated receptor
mediated cell signaling. Watch it twice, then summarize your learning.
http://bcs.whfreeman.com/thelifewire/content/chp15/15020.html
Three stages of receptor mediated cell signaling exist: Receptiontransduction-
response (effect).
Describe these events for cells of liver stimulated during the fight or flight response.
Log in to www.discoveryeducation.com
Username nbrown@mayfieldschools.org
Password
discoveryeducation
Type this phrase into the search bar: Biologix: The neuroendocrine system
Watch the movie, stopping to take notes as needed. YES, I KNOW THE TEACHER IS
CREEPY, but he does a GREAT job explaining!
1. How do neurons signal other cells?
2. How does the endocrine system control other cells?
3. compare and contrast these characteristics of nervous system signaling and
endocrine signaling:
nervous
endocrine
Cells used to send signals
Method of signal delivery
Targets—types of cells &
specific versus generalized
responses
Speed of signal delivery
and response
4. What is different about the way an action potential would affect a muscle versus
the secretion of growth hormone? Why?
5. For temperature regulation, homeostasis requires interaction of nervous and
endocrine systems. The hypothalamus integrates these systems. Draw a graph
showing the role of the hypothalamus’s nervous system mediated controls on
temperature versus its endocrine mediated role (think thyroid stimulating hormone… )
if you’re struggling, look up temperature regulation in the index of your book.
6. Explain the antagonistic effects of glucagon and insulin on blood glucose
concentrations via negative feedback.
Stay at the discovery education website, but type into the search bar:
Biologix: nerve impulse conduction
STOP at 21 minutes.
Goal—be able to explain the formation and events of the action potential
1. Neurons effect other _________________ and their effectors which may be
either ______________ or _______________________
2. Draw 2 neurons that communicate with each other. Label dendrites, cell body,
axon, axon terminus, myelin sheet, and synapse. Explain what happens at each
part of the two neurons.
3. What is the role of the Na+/K+ pump?
What is the size of the resting membrane potential?
Why does the Na+/K+ pump have to work continually, even when the nerve cell
is resting for a long time?
4. How many action potentials could be sent by a fast, myelinated neuron within a
minute, even considering the refractory period?
5. What cells form the myelin sheath? What is a node of ranvier? What is
important about the nodes of ranvier? How does myelination affect the speed
of an action potential? What does salutatory conduction mean?
Cell signaling and cell transport in the immune system
http://highered.mheducation.com/sites/0072507470/student_view0/chapter22/anim
ation__the_immune_response.html
Watch this animation twice, then take the quiz below it.
1. Diagram the steps of the immune response.
2. Describe the role of active transport in macrophage action.
3. Describe the role of receptor mediated signaling in the ability of macrophages
to activate T helper cells and of T helper cells to activate cytoxic T cells and B
cells.
http://www.hhmi.org/biointeractive/cloning-army-t-cells-immune-defense
This is a very complex video. You don’t need to remember details. What you need to
understand is the way that activation of a T helper cell (via its receptor that binds
antigen on an antigen presenting cell’s MHC receptor) involves the 3 stages of receptor
mediated signal transduction (receptionsignal transduction response), as well as
how it employs exocytosis, during an autocrine response. Try to explain it in general
terms.
MHC-antigen + ____________--> p_______________ of pr____________________
that result in production of s____________________ m___________________ that
result in the cell’s increasing production of i____________________-2 that it releases
via e___________________________ . The i_________________-2 stimualtes IL-2
R_____________proteins on it’s membrane, resulting in the cell’s d_______________
to produce an army of T helper cell clones directed against the same antigen.