CCTS Town Hall
&
Information Session
August 15, 2013
Philip A. Kern, MD
CCTS Director/CTSA PI
CCTS Town Hall & Information Session
CCTS Needs Assessment & Satisfaction Survey!
We hear you!!
If you have used one CCTS service,
you know about one CCTS service.
CCTS Utilization
During the past 12 months, did you
utilize any CCTS services or receive any
CCTS support?
Overall, has your research benefited in any
way from the CCTS resources or services in
the past 12 months?
11%
15%
No
39%
Not At All
Yes
61%
Yes, somewhat
Yes, significantly
34%
I do not know
40%
91% of 333 respondents reporting utilization of CCTS services or support over the
past 12 months also report that their research has benefited from that support.
If you did NOT use CCTS resources or services in the past 12 months, why
not? (N=106)
I did not know what services are available
16%
I did not know how to access these services
Resources are available to me from another source
4%
39%
CCTS resources are too costly
12%
CCTS resources are not appropriate/adequate for
my needs
CCTS resources take too much time to obtain
4%
Other (please specify)
17%
8%
CCTS Services you were not aware of until now
Novel Methodology Consultation
Study Coordination at Centers for Rural Health
Community Engagement Consultation
Research Concierge
Staff Training
Drug Discovery and Development
Career Development and Support
Mentor Training/Matching
Participant Recruitment Services
Fiscal/Grant Management Services
Functional Assessment and Body Composition Lab
Funding for Career Development
Ethics/Regulatory Support
Biochemical Analysis Laboratory
Courses and Programs
Clinical Services
Biostatistics/Research Design
Biomedical Informatics
CCTS Portal/Web page
CCTS Pilots
0.0%
10.0%
20.0%
30.0%
40.0%
50.0%
60.0%
70.0%
CCTS Town Hall & Information Session
Outline
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Presentation: Services, Pilot Awards, Education Programs
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Intros: CCTS Core Directors/Co-Directors/Key Staff

Q & A Session

Info Session & Reception in Chandler Hospital Atrium
CCTS Timeline
1985: General Clinical Research Center (GCRC): 5 renewals to 3/31/08
2002: UK Clinical Research Organization (UKCRO)
2006: Center for Clinical and Translational Science (CCTS)
2007-09:
4 CTSA Submissions – Jan & Nov 2007, Oct 2008, Oct 2009
2009:
Consolidation of GCRC/CRO → (CR-DOC)
2010:
5th CTSA Submission: Oct 2010
2011: CTSA awarded June 1, 2011 – member of CTSA Consortium
2013: CTSA Project Year 3 (March 1 – February 28)
CCTS Key Functions, aka Cores
Portal (Website & Research Concierge)
Clinical Services Core (now CSC, was GCRC, UKCRO, CR-DOC)
Regulatory Support & Research Ethics
Biostatistics, Epidemiology & Research Design (BERD)
Biomedical Informatics (BMI)
Pilot & Collaborative Studies
Novel Clinical & Translational Methodologies
Drug Discovery & Development (DDD)
Translational Technologies (Biospecimens Core)
Training, Education & Mentoring (TEAM)
Community Engagement & Research and
Appalachian Translational Research Network (ATRN)
 Risk-related Behaviors & Substance Abuse
 Marshall University Partnership
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CCTS Services: Access
Research Concierge: Elodie Elayi, MS
Contact: elodie.elayi@uky.edu, 859-323-7939
CCTS Website: http://www.ccts.uky.edu/
Consultations, Services, Resources, Tools for:
 Designing a Study
 Setting up a Study
 Conducting a Study
 Closing out a Study
Clinical Services Core (CSC)
 Inpatient (5 North)/Outpatient (C-300 UKMC)
 Nursing, Study Coordination
 Marketing/Participant Recruitment
o Clinical Research Opportunities Wildcat Database
o ResearchMatch
 Biochemical Analysis & Body Composition Labs
 Financial Management – industry contracts
 Regulatory – IRB submissions, QA/QI audits, DSMB
Access: Submit CSC Service Request Form at www.ccts.uky.edu
Biostatistics, Epidemiology & Research Design (BERD)
 Consultations on study design – pre-study initiation preferred!!
o Clinical Trials
o Community-based Participatory Research
o Population-based (epidemiologic) Studies
 Quantitative data analysis
 Protocol review
For: Pilot Studies, Grant Submissions, Publications
Info:
Pizza & Pilots (at lunchtime the last Monday of each month)
OR:
Email request to: Catherine.Starnes@uky.edu
Biomedical Informatics (BMI)
 Enterprise Data Trust (clinical data warehouse)
o Datasets: UKHC inpatient data, Markey Cancer Center,
Kentucky Cancer Registry, KY Medicaid,
Social Security Death Master File
o Data extractions: On request
 Consultations with faculty in Division of Biomedical Informatics
o Expertise: Bioinformatics, data mining, database design, data visualizations,
imaging informatics, natural language processing, social network analysis
 Informatics Tools
o REDCap: data collection & surveys
o i2b2: quick aggregate counts on available patient populations
o Request account: http://www.ccts.uky.edu/BIC/InformaticsTools.aspx
Info:
Contact:
Tamela Harper, MHA
Project Director
Tamela.harper@uky.edu; 859-257-9384
Novel Development 1
 Biospecimens Core
o Blood, urine, fingernails of 102 women in Kentucky Women’s Health Registry
o Expansion to Appalachian Kentucky
o Assistance with access to biospecimens collections at UK, other institutions
o
Enhanced biobank/tissue bank!
Access: biospecimens@uky.edu
 Drug Discovery & Development (DDD)
o Therapeutic Advisory Panel – experts on drug development
o Medicinal chemistry, assessment of HERG channel interaction,
virtual screening & predictive toxicology
o Pilot awards in drug discovery & development
Info: To schedule a consultation, email Charolette Garland
cawgarland@uky.edu,
Novel Development 2
 Community Engagement & Research
o Consultations to facilitate community-oriented research
& research collaborations
o Training for community-oriented research
o Seed grants for community partners
o Study Coordinators & Clinical Liaisons in Hazard and
Morehead to support research activities
 Appalachian Translational Research Network (ATRN)
o Research collaborations & new avenues to address
health challenges and health disparities in Appalachia
o UK, OSU, Ohio U, WVU, U of Cincinnati, Marshall, U. of Pikeville
Info:
Contact:
Carol White, MPH
Program Manager
crwhit3@email.uky.edu; 859-218-0588
Center for Rural Health,
Morehead
Ohio State
University
University
of Cincinnati
University
of Kentucky
Center for Excellence
in Rural Health,
Hazard
Appalachian
Translational
Research
Network
West Virginia
University
Ohio
University
Marshall
University
University
of Pikeville
Pilot Awards Program
 32 Awards since CTSA initiation for total of $1,102,988
 11 NIH awards ($6.9M) from CCTS pilots since 2007 program initiation
 January RFA: Joint pilots – UK Centers & CCTS Partners,
Community Engagement, Drug Development
 July RFA: All other pilot programs
 New RFA in 2013: Novel Device Development
 Standing Pilot Review Committee
Info:
Contact:
Elodie Elayi, MS
Research Development Director
elodie.elayi@uky.edu, 859-323-7939
You can ensure our resources are
available for all future research.
CitE!
Cite grant number UL1TR000117
for the NIH CTSA at UK
Categories Of Pilot Funding
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Junior Investigator Award: $25,000
High Impact and Innovative Award: $50,000
Community Engagement Award: $25,000
Drug Development Award: $50,000
CCTS Partners (OSU, UC, WVU) Collaborative Awards: $50,000
CCTS Centers (BB, SB, MCC, SCoBIRC) Collaborative Awards: $50,000
Community Engagement Mini Grant Awards: $2,500
Marshall University Partnership: $25,000
Novel Methodology Awards: $15,000
ACCELERATING DISCOVERIES TOWARD BETTER HEALTH
Training, Education & Mentoring (TEAM)
KL2 Career Development Program for 6 Junior Faculty
 75% release time, research support, mentoring, career development
 3 KL2 Scholars awarded NIH grants
Brandon Fornwalt, MD, PhD, Pediatric Cardiology
Brian Noehren, PT, PhD, Rehabilitation Sciences
Qing-Bai She, PhD, Markey Cancer Center
TL1 Institutional Training Program for Pre-doctoral Students
 Stipend, tuition, health insurance for 4 pre-doctoral students
Professional Student Mentored Research Fellowship (PSMRF)
 Introduction to Clinical Research Course/Workshop
 1-year mentored research ($3,000) for 25-30 professional students
Training, Education & Mentoring (TEAM)
Certificate and Degree Programs
 Graduate Certificate in Clinical and Translational Science
 Graduate Certificate in Clinical Research Skills
 MS in Medical Sciences – Clinical & Translational Science
Pathway
 PhD in Clinical and Translational Science
Other Career Development Activities
 One-on-one Coaching & Mentoring
 K Club for KL2 Scholars, Pilot Awardees
 CTS Seminar for TL1, Certificate, PSMRF, MD/PhD Students
 Coordinator 101 & Clinical Research Updates for Clinical Researchers
Info:
Contact:
Victoria King, PhD
Research & Leadership Development Director
vicky.king@uky.edu; 859-323-1225
8th Annual CCTS Spring Conference: April 8, 2013
 5 Conferences
CCTS Spring Conference
Community Faculty/PBRN Conference
Research Day: Dentistry, Neuroscience,
Public Health
648 attendees; 251 oral/poster presentations
 Keynote: Chris Austin, MD, Director,
National Center for Advancing Translational Science (NCATS)
9th Annual CCTS Spring Conference: Thursday, March 27, 2014
 CCTS Spring Conference
 ATRN Annual Meeting
 Research Day: Dentistry, Health Sciences, Neuroscience, Nursing
Cite! Campaign: Cite UL1TR000117
When to cite: UL1TR000117
 Research with CCTS $$
o
o
o
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CCTS Pilot Awards
CCTS Seed Grants and Mini-grants
KL2/TL1 support
CCTS subsidized research projects and protocols
 Faculty/staff funded by CCTS where research benefited
 Research utilizing CCTS services, resources, facilities, tools, equipment
 Less direct CCTS funding but still appropriate for citation:
o Technical assistance
o Faculty/staff funding contributed to research
o Assistance with collaborations, research development
Benefits of citing the CTSA – UK Basketball Tickets
 2 sets of 2 basketball tickets – pre-SEC & SEC
 Who is eligible: First, Last, Corresponding
Author on publications citing CTSA:
UL1TR000117, KL2TR000116, TL1TR000115
 How to enter:
o Watch for email announcement on CCTS listserv
o We will solicit entries from PubMed search for citations
o Eligible author to send publication citing CTSA to Barb Ramsey
o Drawings in late fall, early winter
 Winner of tickets may determine who gets them, e.g., other member
of research team! NOTE: Tickets may not be sold!
Any questions?
Q & A Session
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BERD
Biospecimens
BMI
Community Engagement
ATRN
CSC
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Dick Kryscio, Heather Bush, Catherine Starnes
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Ken Campbell
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Todd Johnson, Tamela Harper
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Nancy Schoenberg, Kevin Pearce, Carol White
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Patrick Kitzman
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Peter Sawaya, Marietta Barton-Baxter ,
Linda Rice, Brian Raisler
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MCL
NCTM
Pilot/Research Concierge
Regulatory
TEAM
•
Susan Foster-Harper
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Greg Gerhardt, Eric Grulke
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Elodie Elayi
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Ada Sue Selwitz, Marietta Barton-Baxter
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Tom Kelly, Vicky King