CCSG-CTSA
Interactions
Michael Bertram, PhD, MBA
Associate Director for Administration
UAB Comprehensive Cancer Center
Kara Newton
Administrative Director
UAB Center for Clinical & Translational Science
Brian C. Springer, MHA
Executive Director
Siteman Cancer Center
Barnes-Jewish Hospital & Washington U. School of Med
Overview
•
•
•
•
•
Overview of CTSAs
Development of the Applications
Collaborative Culture
Relationship at the Site Visit
Future Directions
We encourage discussion along the way …
Overview of CTSAs
Strategic Goals Across the Consortium
1. National Clinical and Translational Research
Capability
2. The Training and Career Development of Clinical
and Translational Scientists
3. Consortium-Wide Collaborations
4. The Health of our Communities and the Nation
5. T1 Translational Research
Overview of CTSAs
Overview of CTSAs
Each CTSA institution has
created a home for clinical
and translational science.
Input from the NIH and
other federal agencies,
industry, and private and
community organizations
helps guide the work of
every CTSA institution.
Our Respective CTSAs
THE UNIVERSITY OF
ALABAMA AT BIRMINGHAM
Center for Clinical and Translational
Science
• Funded in 2008
• Unique Drug Discovery Component
• Novel Collaborations with Southern
Research Institute & HudsonAlpha
Institute for Biotechnology
• 9 Research Cores
• 2 Research Education Programs
• Dual Community Engagement
Program
One Great Community &
Deep South Network
•
•
•
•
•
•
Funded in 2007
8 Collaborating Institutions
5 Clinical Research Cores
12 Other Research Cores
2 Research Education Programs
4 Community Engagement
Programs
… Briefly, Application Development …
• Council for Center Directors
• Council of Centers
• Council for Translational
Research (CCC Represented)
• Council of Administrators
• CCTS Biomedical Informatics
Synergized Institutional efforts:
CCC, UAB Health System, UAB IT
• Catalyzed the establishment of a
Division of Biomedical Informatics
• Broad collaboration in all areas
between ICTS and SCC
• Leveraging of programs and
relationships …
• … and infrastructure and grant
materials
Collaborative Culture
• Shared Leadership
Advisory Boards & Executive Committees, Core Directors,
Deep South Networks, Council for Translational Research &
Working Groups
• Broad Institutional Initiatives
Informatics, caBIG, Clinical Data Warehouse, Drug Discovery
Program, Clinical Research Operations, SOM Strategic
Planning, VA Research Activities
• Leveraging Stakeholders’ Investments
Collaborative Culture
•
•
•
•
Strong Institutional Investment
Shared Leaders (ICTS/SCC)
New Seminar Series
Monthly Management Meetings
(ICTS/SCC)
– Best Practices (membership, citations, EAB)
– Joint Project
– Ability to Represent Joint Interests
Shared Resources
ICTS
28 shared
resources
SCC
14 shared
resources
5 shared cores + 1 developmental
Biostatistics, Biomedical Informatics, Human Imaging (IRAT/HIU),
Proteomics, Tissue, Plus Developmental (HAMLET)
Shared Resources
Philosophy behind multiple subsidies:
Personnel Personnel Personnel
(ctr grant)
(JIT
(other)
grants)
$$$
Subsidy
for
Siteman
members
$$$
Subsidy
for ICTS
members
$$$
Supplies
Equip
Dep
Other
$$$
$$$
$$$
For two years, shared electronic
user survey for all ICTS and SCC
shared resources.
Transformative Partnerships
Academic Drug Discovery
and Development at
UAB & SRI:
UAB
School
of
Medicine
UAB
CCC
Alabama Drug
Discovery
Alliance
Southern
Research
Institute
UAB
CCTS
• Molecular Library
• High through-put
screening
• 3D structure of targets
• Medicinal chemistry with
in silico screening
• Preclinical toxicology
and ADME analysis
Pilot Projects
FY11 over $1 million in co-sponsored projects
FY11 over $120,000 in CTSA partnerships and
$150,000 in Drug Discovery Alliance
projects from UAB CCC
• CCTS/University-wide Centers match program
• CCC/CCTS Drug Discovery Projects
Nascent Projects Panel (shared mentorship)
Streamlined online application & review process
Pilot Projects
• Robust BJHF-ICTS Funding Program (>
$1 million/year)
• Many SCC Pilot Programs (2011 > $1
million)
• Sharing credit for each others’
successes
Information
Resources
• Publications – joint input
• Web resources
• Shared resource listings
Information
Resources
University-Wide Center Listserv
For Announcements &
Opportunities
CCC Monthly e-Newsletter,
Quarterly Magazine, Facebook
CCTS Weekly e-Digest,
Quarterly Newsletter, Twitter
Institutional Impact
• Key Components of SOM Strategic Planning
– Cancer 1 of 6 priority research themes
– CCTS 1 of 5 cross-disciplinary platforms
• Catalyze Research Center Interactions
• Representation for Campus-wide Systems
–
–
–
–
Integrated Information Systems
Shared Facility Coordination
Phase I Clinical Trials Unit Priority
Enterprise Wide Adoption caBIG CTMS
• Together, We Are Stronger
Institutional Impact
• SCC as a trailblazer
• Strength of both centers in partnership
to foster institutional change
• Increased grant funding
• More collaborative culture
Best Practices?
• So what have you tried that has
worked???
Site Visits
• CCTS Director participated in CCC Site Visit highlighting
collaborations during the Director’s overview
Future Directions
• Greater consolidation
• Greater leverages
• CTSA transition to new NIH Institute targeted for
October 2011
• National Center for Advancing Translational Sciences
(NCATS)
– Emphasis on T1 research
– New and more effective therapeutics
– New NIH-FDA partnership activities
Last Thoughts