The AP Bio Midterm Exam
Tuesday 1/22/13 8AM
AP Midterm Exam Format
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24 True/False (36 pts. Total)
72 Multiple Choice (144 pts. Total)
2 Genetics Problems (40 pts. Total)
4 Short Answer Questions (30 pts. Total)
1 Full Essay (50 pts. Total)
… and Extra Credit!
Calculators Permitted / Formula Sheet Provided
Multiple Choice
 Some questions will be fact-based
 Which of the following occurs during meiosis but not
during mitosis?
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A)
B)
C)
D)
E)
separation of sister chromatids
cell division
crossing over of homologous chromosomes
breakdown of the nuclear envelope
lineup of chromosomes in the center of the cell
Multiple Choice
 Some questions will be fact-based
 Which of the following occurs during meiosis but not
during mitosis?





A)
B)
C)
D)
E)
separation of sister chromatids
cell division
crossing over of homologous chromosomes
breakdown of the nuclear envelope
lineup of chromosomes in the center of the cell
Multiple Choice
 Some questions will ask you to apply your knowledge
 70% of earth’s population is lactose intolerant. The gene
for lactose metabolism in intestinal cells is not
expressed after the age of three. The majority of
Europeans and US residents with European ancestry are
lactose tolerant. Their intestinal cells continue to
produce lactase throughout life. This mutation has been
traced to a single G to C mutation approximately 14,000
base pairs upstream of the lactase gene.
Multiple Choice
 Some questions will ask you to apply your knowledge
 The model that best represents the likely effect of the
mutation is that the G to C change has:
Multiple Choice
 Some questions will ask you to apply your knowledge
 The model that best represents the likely effect of the
mutation is that the G to C change has:
Multiple Choice
Multiple Choice
Multiple Choice
Genetics Problems
 Hemophilia is a recessive sex-linked disorder that
prevents blood from clotting properly. If a man with
hemophilia has a child with a woman that does not
have hemophilia, what are the overall odds that they
will have a child with hemophilia? (You don’t have
any further information on the woman’s background)
Genetics Problems
 Hemophilia is a recessive sex-linked disorder that
prevents blood from clotting properly. If a man with
hemophilia has a child with a woman that does not
have hemophilia, what are the overall odds that they
will have a child with hemophilia? (You don’t have
any further information on the woman’s background)
 Overall 2 in 8 (25%)
Genetics Problems
Short Answer
 An electrophoresis gel from the Sanger method
produces the following results. Based on it, give the
DNA sequence for the original strand of DNA.
ddATP
ddCTP
ddTTP
ddGTP
ddATP
ddCTP
CGCAGCGATACT --- >
ddTTP
ddGTP
GCGTCGCTATGA
Full Essay