The Oxidative Steps of the Pentose
Phosphate Pathway
Mistake in book
NOT reversible
Figure 22.23 The glucose-6-phosphate dehydrogenase reaction is
the committed step in the pentose phosphate pathway.
The three most energy consuming
Reactions of glycolysis are replaced in
gluconeogenesis, NOT just the ones in
Glycolysis that consume ATP as stated
in lecture.
A way to remember which ones differ
First two and last reaction differ.
The ones here without double arrows.
Glycolysis substrates
Good Gracious Father Frank Did Go By Picking Pumpkins (to)
Prepare Pie.
Glucose
Glucose 6-Phosphate
Fructose 6-Phosphate
Fructose 1,6 Bis-Phosphate
Dihydroxyacetone Phosphate
Glyceraldehyde 3-Phosphate
1,3- Bisphosphoglycerate
3-Phosphoglycerate
2-Phosphoglycerate
Phosphoenolpyruvate
Pyruvate
Glycolysis enzymes
"High Profile People Act Too Glamorous, Picture Posing Every Place":
Hexokinase
Phosphoglucose isomerase
Phosphofructokinase (PFK)
Aldase A
Triose phosphate isomerase
Glyceraldehyde-3-phosphate dehydrogenase
Phosphoglycerate mutase
Enolase
Pyruvate kinase
Citric acid cycle compounds
"Oh Citric Acid Is Of (course) A SiLly STupid Funny Molecule":
Oxaloacetate
Citrate
Aconitate
Isocitrate
Oxalosuccinate
Alpha-ketoglutarate
SuccinyL-CoA
SuccinaTe
Fumarate
Malate
· SilLy and sTupid used to differentiate succinyL and succinaTe
Deficient enzyme in glycogen storage disorder
A-B Anderson-(glycogen)Branching enzyme
C-D Cori's-(glycogen)Debranching enzyme
M-M Mcardle's-Muscle glycogen phosphorylase
H-H Her's-Hepatic glycogen phosphorylase
G6PD: oxidant drugs inducing hemolytic anemia
AAA:
Antibiotic (eg: sufamethoxazole)
Antimalarial (eg: primaquine)
Antipyretics (eg: acetanilid, but not aspirin or acetaminophen)
Carbon monoxide: electron transport chain target
"CO blocks CO":
Carbon monoxide (CO) blocks Cytochrome Oxidase (CO)
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Electron transport chain: Rotenone's site of action
Rotenone is a site specific inhibitor of complex one.
Metabolism sites
"Use both arms to HUG":
Heme synthesis
Urea cycle
Gluconeogenesis
· These reactions occur in both cytoplasm and
mitochondria.
Glucagon function
"Mr. Gluca has Gone to the cAMP to bring out some Glucose":
· Glucagon elevates glucose by cAMP mechanism.