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Welcome to
Bio181L!
Contemplating the nuts & bolts of Life
“It’s atoms all the way down”
About me...
Candice Eaton
Email: ceaton@email.arizona.edu
Office hours: Tuesday 10:30-11:30 Koffler
422 or by appointment
Facebook group: MCB 181L sections 29 and
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What 181L is
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Thinking, Understanding, Investigating, Evaluating
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Not arrive, assembly line, leave
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Manual pp. ix & xi should help
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Not sync’ed with most lecture sections, but internally coherent &
mutually reinforcing
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About you
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Attendance vs. UAccess.arizona.edu
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NAMETAGS!!!!
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Meet someone new
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181 Lab ACCOUNTS
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http://blc.arizona.edu/courses/181lab (Safari home page)
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Click ‘Create Accounts’
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Your section number is:
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Bio181L_Go is the way to do your work. Browser bad
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While waiting, fill out a card (name on front; on back, 1-2
‘interesting things about me’ sentences).
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29 if Wed. 45 if Thur.
Come up & let me photo you (please)
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80% of success is just showing up*
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Absences must be excused by Asya Roberts
asya@email.arizona.edu in BSE109 prior to making up.
Contact her as soon as possible. Really.
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Late is absent. Leaving early is absent.
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Labs cannot be offered week after they are delivered; Avoid
missing a lab
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Missing 2 labs => you’ll be dropped from the course--excused
or otherwise (b/c you’ll have little shot at learning what you
need)
*--Woody Allen
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My Webpage
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Get there via homepage* => Instructors => Sxn#
*http://blc.arizona.edu/courses/181Lab
(Lab Man yellow page)
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Web page operation
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Policies & Grading
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Syllabus (Linked on course homepage)
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Honor code & Plagiarism (Manual, p. xiii)
Assignments
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On-line assessments/tutorials (10%)
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In-class quizzes (15%)
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Lab assignments (LABAs--Lab Activity Based Assignments) (50)
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Lab Projects & reports (combine to 25%)
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Every assignment is posted & reported on basis of 100%
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For electronic assignments, log in again to see your recorded score
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Also reported to you at the end
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How?
Why?
the Tao of Molecules
How molecules feel & the world they live in
Primary goals
• Create understanding by observation,
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reasoning
Chemical foundations for the course:
• Water & its properties
• non-watery things
• Know molecules as real & tangible things
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When a journalist asked the great physicist Richard
Feynman what single sentence would best
encapsulate all science so far if it were to be the
sole surviving scrap of all we knew, he replied, “The
world is made of atoms.”
From The Secret of Scent, Luca Turin p.28
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Atoms: They’re how life works
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DNA, RNA: C, H, N, O, P, [Mg++]
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Carbs: C, H, O
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Protein: C, H, N, O, (S), (P), [traces]
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Membranes: C, H, N, O, P, (S)
What cannot be done with assemblages of these atoms*
cannot be done by living organisms, nor their cells, nor their
spit, etc.
*OK, fine, there’s the occasional role for Ca++, etc.
Who am I?
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At birth, # protons = # electrons
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Atoms seek completion, which means outermost electron set = 8
(hydrogen, helium it’s just 2)
Freeman Fig. 2.1a
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Symbolizing
Atoms & Molecules
Coloring your world
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Views of Water
(There will be a test)
+
H2O
+
-
H
See lab manual, p. 0-3
O
H
Interacting with H2O
To your StructViewers!
Desktop => Bio181L_Go
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Doing it
Computers, stations
Write your group name down; otherwise you
can’t retrieve your work!
How to draw molecules
Carbon Hydrogen Oxygen Nitrogen
Figure is from Lab Manual p. 0-5
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TA-lead discussions
“Salting out”
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It’s a real term; used to refer to a situation where the addition of
salt (portable charges) alters the solubility of other molecules in
water
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Why should this be?
Evaporation
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First things first--what is it? What’s going on in terms of molecules
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Experiment: Ethanol and water on your arm: which is cooler & why?
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Prediction: based on molecular weight, which should evaporate
more quickly--H2O (2 x 1 + 1 x 16) or CH3CH2OH (5 x 1; 2 x 12; 1 x 16)
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If not, why not?
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Salt--ever tasted your sweat? Or anybody else’s for that matter?
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What benefit might there be to adding NaCl to water that you
are intending to evaporate?
Clean up!
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Oil waste in the hood
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ethanol waste in the sink
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anything too messy wadded up and discarded
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Some advice
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http://www.damnlol.com/please-do-me-right-now-224.html
What’s an Assessor?
=>Chatting<=
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What’s vocabulary homework?
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EITHER both versions of the crossword exercise
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OR VocabuWary with a better than threshold score
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For “Atoms & Molecules”, F12, that’s 60,000
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Errors count off. Slowness counts off.
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Homework
due 10 p.m. before lab
Assessor: 181 Intro ’12
Assessor: Molecular World Tutorial
Vocab Atoms/Mols: xWord(x2) or ‘Wary
Next week’s quiz will include
Questions on page 1-9 (50%)
Atom colors
Deducing partial charges (from tutorial)
Manual Ch. 2
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Follow-up, extras,
etc. (you can
ignore)
A buffet of the MolTao
Great experiments
Molecules: two dimensions or three?
For 3D: ‘Duo_Comparator’ in Lab01_Tao folder
Compare tetrahedron_1 and _2
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Thinking about big pictures
Macro molecules
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magnetic waters--magnets with poles lined up
appropriately for H, O
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inert ping pong balls
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Mix...
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Non-newtonian fluids
for fun
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Running on water
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Cornstarch on a subwoofer
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Longer, better running + subwoofer + bowling ball
Water and ice
http://biomodel.uah.es/en/water/index.htm
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Why does Chemistry
matter?
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Because...
“Any organism in equilibrium with its environment is
dead.”
--Bruce Averill and Patricia Eldredge, Chemistry 2005
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Atoms: mainly empty
http://www.phrenopolis.com/perspective/atom/
Also available under ‘Further Explorations’ for this week, titled ‘where’s an electron’
Some perspective
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Electromagnetism: force between 2 charged particles; inverse distance
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1% excess of (+) charge force on one person & 1% (-) on person nearby
=> collision w/ enough force to knock earth out of orbit around sun
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strong nuclear force (always attractive; holds nucleus together; executed by
gluons) overcomes charge repulsion
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electron location is POTENTIAL energy until movement (between orbitals) is
allowed
All derived from the Teaching Company’s “The Physics of History” lectures delivered by David Helfand, Ph.D.
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We also now appreciate that molecular biology is not a
trivial aspect of biological systems. It is at the heart of the
matter. Almost all aspects of life are engineered at the
molecular level, and without understanding molecules we
can only have a very sketchy understanding of life itself.
--F. H. C. Crick, What Mad Pursuit, p. 61