Environmental Health Training in Emergency Response Special Health Concerns CDR William Greim, MS, MPH, REHS/RS CDC, Atlanta, GA Richard Wellinghurst, RS. Louisville Metro Health Department, Retired Special Health Concerns Biological Chemical Radiological Intentional Terrorism Non-intentional Accidents Natural events OBJECTIVES • Discuss three areas of special health concerns from an environmental health perspective. • Describe critical information needed to respond to these events. • Discuss health and safety issues for responders. Terrorism and Public Health Response • The techniques and strategies used today in public health emergency planning for the most part transcend terrorism and can be used in any public health emergency. • Some differences can include: – – – – Lead Agency Size and Scope of Response Risk Communication Messages Evidence Issues Public Health Issues After a Disaster • • • • • • • • • • • • • • • • • Assessment of Health and Medical Care Delivery Rapid Assessment of Community Health/Medical Needs Delivery of Health and Medical Care Pharmaceutical Supply Potable Water, Safe Food, and Sanitation and Hygiene Injury and illness Surveillance Vector Control Solid Waste Hazardous Materials Registry Mental Health Sheltering and Housing Mass Congregation Handling of the Deceased (humans and animals) Staffing Rumor Control Public Service Announcements/Media Environmental Health Roles • • • • • • • Planning and exercising Health Educator Risk communicator Detection and monitoring Regulatory enforcement Health Assessment Exposure studies Terrorism Attack and Environmental Delivery Agents Biological Chemical Radiological Environmental Delivery System Targets Public Environment Agriculture Air - Food -Water Threats to Food Security • • • • • • • Food distribution chain Employees Physical security Raw materials Food processing plants Packaging Imported foods Issues for Food Safety and Bioterrorism • Exposure to foods is universal • Complex nature of the food supply – Foods are often widely distributed – Open food market system means many potential critical control points – Many persons/organizations involved from farm to table • Lab methods are directed at the usual suspects • “Agroterrorism” direct attack on plants and animals Addressing Foodborne Bioterrorism • Strengthening the food safety infrastructure – Adequate staffing, training, facilities, laboratories, communication • Developing an effective LRN for food – Methods for select agents – Functional integration of public health, agriculture, and regulatory labs that deal with clinical and food specimens • Exercising the partnerships between public health and food safety with every foodborne outbreak • Expecting the unexpected Threats to Drinking Water • Biological agents • Chemical agents -industrial, natural toxins – Direct injection – Secondary contamination • Radiological agents • Damage, destruction of physical infrastructure • Disruption to computer systems Threats to the Air \ Environment BioWatch • Environmental monitoring • Collaboration with Homeland Security, EPA and cities/states • LRN expedited assay development, reagent production for high throughput real-time PCR testing • 19 LRN/BioWatch facilities support air sampling in 30 US cities An example of a BioWatch Monitor Public Health Response Public Health System Environmental Health Laboratory Epidemiology Laboratory Response Network 2005 The LRN and its partners will develop and maintain an integrated national and international network of laboratories that can respond quickly to acts of biological or chemical terrorism and other public health emergencies. Classification of Bioterrorism Laboratories Level D Lab BSL-4 D - High level characterization (seek evidence of molecular chimeras) and secure banking of isolates Safety & proficiency to probe for universe of bio- and chemical agents in non-clinical specimen Level C Lab BSL-3 Level B Lab Work at BSL-3 with BT agents Level-A Labs - Assess Risks for Aerosols and Use Biosafety Cabinet C - Safety and proficiency sufficient to probe, type, perform toxigenicity testing B - Safety and proficiency adequate to confirm & characterize susceptibility A - Adequate safety to rule-out and forward organisms Bioterrorism: Priority Agents Most likely used Easily disseminated or transmitted High mortality and morbidity Special public health preparedness Panic and social disruption Category A Agents: Anthrax Botulism Plague Smallpox Tularemia Viral Hemorrhagic Fevers Category B Agents • Brucellosis • Epsilon toxin of Clostridium perfringens • Food safety threats • Glanders • Meliodosis • Psittacosis • Q fever • Ricin toxin • Staphylococcal enterotoxin B • Typhus fever • Viral encephalitis • Water safety threats Category B Agents • Moderately easy to disseminate • Moderate morbidity rates and low mortality rates • Require specific enhancements of diagnostic capacity and disease surveillance Category C Agents • Emerging infectious diseases such as Nipah virus and hantavirus • Could be engineered for mass dissemination in the future because: • Availability • Ease of production and dissemination • Potential for high morbidity and mortality rates and major health impact Incubation Period • Toxin weapons: minutes to hours to days • Viral and bacterial weapons: days to weeks • Fungal weapons: weeks to months • Some other bio-agents: up to several years Survivability of organisms • Anthrax: days and weeks in the air and years (on surfaces) • Brucellosis: up to 2 days in the air • Coccidioidomycosis: days and weeks in the air • Ebola: 30 min (liquid) in the air and up to several hours (dry) • Glanders: several hours in the air • Marburg: 30 min (liquid) in the air and up to several hours (dry) • Plague: 1 to 2 hours in the air • Smallpox: up to 24 hours in the air • Tularemia: several hours to one day in the air • Q fever: up to several days in the air • H5N1 avian: room temperature 1-7 days No. Affected Infectious Disease Outbreak Exposure Symptoms Seek Care Time (days) Chemical Exposure No. Affected Exposure Acute symptoms Chronic symptoms Time (in minutes or hours) Time (in years) Specificity and Response Pre-diagnostic………Diagnostic..…...…Laboratory Public Health Information Anthrax Gram positive spore forming bacterium Bacillus anthracis Spores highly stable Viable in soil for decades Viable/infectious in aerosol form Zoonotic disease of herbivores Epidemiology of Transmission Cutaneous anthrax Oropharyngeal and gastrointestinal anthrax Pulmonary/mediastinal anthrax Direct contact and fly bites Ingestion Inhalation Infected herbivores and soil are reservoir Infection Control Anthrax • No person-to-person transmission • Use standard precautions • Avoid direct contact with wound or wound drainage – Hand hygiene should be performed after any contact with wound or wound drainage – Gloves should be worn when contact with wound or wound drainage is necessary Smallpox Introduction Smallpox is caused by Variola virus in the genus Orthopoxvirus Last naturally-acquired case on Earth in 1977 Smallpox was declared eradicated in 1980 Epidemiology of Transmission Humans are the Smallpox Virus only natural reservoir Transmission via contact or aerosol • Up to 30% mortality in unvaccinated persons • Any case of smallpox would probably mean an intentional release Infection Control Smallpox • Isolate patients - contact and airborne precautions • For single or few cases use hospital with isolation rooms (negative pressure preferred) • If large outbreak, may need facility designated only for smallpox cases • Notify Public Health immediately Plague Introduction Severe bacterial disease of humans and animals produced by the gram negative nonsporulating bacillus Yersinia pestis • Bite of a rodent flea, or by handling an infected animal • Millions of people died when human dwellings were inhabited by fleainfested rats • Modern antibiotics are effective, but without prompt treatment the disease can likely cause illness or death Types of Plague • Four types of plague • • • • Bubonic plague Pneumonic plague Septicemic plague Oropharyngeal plague “Safety Pin” Y. Pestis in blood Epidemiology of Natural Transmission A B Yersinia pestis Primary bubonic plague A D D Secondary plague cases Flea vector such as Xenopsylla cheopis B C Primary septicemic plague Primary pneumonic plague C Enzootic and epizootic animal reservoirs Routes of Plague Transmission A = Bite of Flea B = Contact with animal or carcass C = Inhalation of respiratory droplets D = Contact with sputum or fluid Infection Control Plague Botulism: Overview Description of Spores Spores can be found in • Soil (commonly) • Marine and Lake sediments • Intestinal tracts of animals including fish Can withstand extreme conditions • Resistant to UV light, irradiation • Survive boiling for up to 4 hours • Survive food processing procedures • Resistant to desiccation Readily killed by chlorine Epidemiology of Natural Transmission Toxin production in foods prepared or stored at ambient temperature Colonization and toxin production in an open wound Botulism: Acute, symmetric, descending flaccid paralysis with bulbar palsies C. botulinum in the soil, flora and fauna Intestinal colonization and toxin production in susceptible infants and adults Infection Control Botulism • Rapid treatment of patients • Identify and eliminate source of outbreak • Determine if accidental or deliberate release vs. endemic disease • Consider bioterrorism if: • Large number of cases • Unusual toxin type • Multiple outbreaks with no common source Tularemia Introduction • Gram negative coccobacillius, Francisella tularensis • Identified in 1911 in Tulare County, California • Also known as Rabbit fever or Deer-fly fever Tularemia Introduction • Organism persists in environment • Infections acquired by: • Bites • Handling infected materials • Ingestion of food, water, or soil • Inhalation of infectious aerosols • Laboratory exposures Tularemia as a Biological Weapon • Highly Infectious when aerosolized • Respiratory infectious dose between 10 and 50 organisms • Possible to produce vaccineresistant and antibioticresistant strains • Easily killed by heat and disinfectants Epidemiology of Natural Transmission A A Ulceroglandular B Vector ticks, biting flies, mosquitoes Francisella tularensis B Glandular Enzootic and epizootic animal reservoirs Rabbits, muskrats, voles, etc. D Oropharyngeal C Oculoglandular C Pulmonary Routes of Tularemia Transmission A = Bite of infected arthropod B = Contact with infected animals, tissues or fluids C = Exposure to infectious aerosols D = Ingestion of infectious materials Viral Hemorrhagic Fevers • Crimean-Congo hemorrhagic fever (CCHF) • Ebola hemorrhagic fever • Hantavirus Pulmonary Syndrome • Hemorrhagic fever with renal syndrome (HFRS) • Lassa Fever • Marburg hemorrhagic fever VHFs • A severe multi-system syndrome in which the overall vascular system is damaged, and the body's ability to regulate itself is impaired. • Zoonotic, rodents and arthropods are the main reservoirs and vectors for viruses causing VHFs. • With few exceptions, there is no cure, vaccine, or established drug treatment for VHFs. • Some HTH transmission-Ebola, Marburg, Lassa Prevention • Avoiding contact with host species • Preventing further transmission from person to person • Controlling rodent populations, safe cleanup of rodent nests and droppings. • Arthropod vectors prevention efforts • Avoiding close physical contact with infected people and their body fluids • Infection control techniques include isolating infected individuals and wearing protective clothing. Lassa Fever virus inactivated by: • • • • o heating to 56 C pH<5.5 or >8.5 UV/gamma irradiation Detergents, 1:100 bleach solution to disinfect surfaces, medical equipment, patient bedding, reusable protective clothing Emerging Diseases • • • • • • Pandemic Influenza SARS West Nile Virus Monkeypox Chagas Disease Antibiotic/Antimicrobial Resistance e.g., MRSA, tuberculosis, malaria, head lice, typhoid fever Pandemic Influenza Avian Influenza A Viruses Infect respiratory and gastrointestinal tracts of birds • Natural reservoir is wild waterfowl - usually infections do not cause disease (wild ducks and geese) • Genetic re re-assortment occurs Viruses are present in respiratory secretions, excreted in feces • Can survive at low temperatures and low humidity for days to weeks • Can survive in water • Disinfection of the environment is needed Transmission • Highly contagious • Primarily person-to-person • – Respiratory droplets: coughing and sneezing • – Direct and indirect contact • – Airborne transmission occurs very rarely, if ever • Incubation period: 1-4 days • Subclinical infection can occur Factors in Infectious Disease Emergence • Ecological Changes • Human Demographics and Behavior • International Travel and Commerce • Technology and Industry • Microbial Adaptation and Change • Breakdown in Public Health Infrastructure • Human Susceptibility to Infection • Economic Development and Land Use • Climate and Weather • War and Famine • Lack of Political Will • Poverty and Social Inequality • Intent to Harm Preparedness for Bioterrorism Event • Trained and staffed public health workforce • Surveillance and epidemiology capability • Laboratory expertise, capacity, and coordination • Communication and information networks • Therapeutic and preventative capability • Partnerships, partnerships, partnerships 1 The Threat Spectrum And Historical Precedents 1 1 10,000,000 Possible Casualties Pathogens Nuclear Weapon Spanish Flu Toxic Industrial Chemicals 1 1,000,000 Hiroshima 1 100,000 Chemical Weapons 0 10,000 Conventional High Explosives Bhopal Radioisotopes Halabja poison gas attack 0 1,000 Tokyo Subway 0 100 World Trade Center Dalles, Oregon Chernobyl Oklahoma City Biotoxins 0 10 0 Bulgarian Assignation Low 1 High 2 Likelihood 3 4 of Occurrence* 5 6 7 8 * Per FBI Briefing, October 2, 2000 Environmental Health Effects TOXICITY • The relative ability of a substance to cause adverse effects in living organisms, • “The Dose is the Poison”, ROUTES OF EXPOSURE • Inhalation • Ingestion • Dermal – Absorption – contact – Injection Environmental Health Effects • Exposure vs. • Contamination Types of “Chemical Agents” • Nerve Agents – Sarin (GB), tabun (GA), Soman (GD), VX • Blood Agents, – Cyanides, a common chemical • Blister agents or visicant – Sulfur mustard ( H, HD, and HT) Lewisite (L), • Pulmonary agents – Phosgene (CG), chlorine http://www.bt.cdc.gov/agent/agentlistchem-category.asp Health Concerns of “Nerve Agents” • ROUTES OF EXPOSURE – Liquid on skin • Very small drop: twitching at site • Small drop: nausea, vomiting, diarrhea • Drop: Loss on consciousness, convulsions, respiratory arrest, flaccid paralysis – Vapor in air • Small: pupils, red conjunctiva, dim vision, nausea/vomiting, runny nose, salivation, shortness of breath • Large: Respiratory and cardiac arrest • TOXICITY – IDLH GB (Sarin) = 0.03ppm (0.2mg/m3) GD (Soman) = 0.008ppm (0.07mg/m3) VX = 0.002ppm (0.02mg/m3) Health Concerns of “Blister Agents” • ROUTES OF EXPOSURE – – – – – Damage to eyes, skin, airways Irritating, painful contact Tissue damage Lewisite effects appear within minutes Sulfur mustard effects appear from 2-24 hours after exposure. • TOXICITY – Symptoms do not improve with time and fresh air – IDLH • Mustard (HD) = 0.7mg/m3 • Lewisite (L) = 0.003mg/m3 Health Concerns of Pulmonary (Choking/Blood) Agents • ROUTES OF EXPOSURE – Irritation of eyes, nose and airways – Inhalation primary hazard • TOXICITY – – – – Shortness of breath Cough / asphyxiation Effects begin up to 24 hours after exposure, IDLH Chlorine Cyanide (AC) Phosgene = 10 ppm (30mg/m3) = 50 ppm (60mg/m3) = 2 ppm (10mg/m3) Radiation, Potential hazards • Major radiation sources and releases, • Health concerns of radiation exposure, Potential “Rad” Incidents • • Radiological – Laboratory – Medical – Transportation – Space – “Dirty” bomb / device Nuclear – Power Plant – Reactors – Weapons Nuclear Power Plants Potential incidents, Possible Targets: There are 103 operating nuclear power reactors at 65 sites across the United States, using nuclear energy to generate electricity. •Plant Security •Waste Generation and Disposal Nuclear Pharmaceuticals • Nuclear Pharmacies located in many communities, • Provide radioactive pharmaceuticals to hospitals and clinics, • Results in radioactive waste in hospitals Radiographic device • May be present for a long period of time before discovery • Could cause health concerns for many people • Will cause widespread public concern Improvised Nuclear Device (IND) • Incorporates nuclear materials designed to produce a nuclear explosion. • Could consist of diverted nuclear weapon components, a modified nuclear weapon, or indigenous-designed device. Faulty Improvised Nuclear Bomb design from an Al Qaeda report A Radiological Dispersion Device, RDD) • Any weapon that is designed to spread radioactive material with the intent to kill, and cause disruption by psychologically and financially impacting Time fuse Radioactive material Detonator Conventional explosive (e.g. fertilizer, semtex) Radiation Exposure Health Effects Exposure With Medical Symptoms Care 100-200 R ≤ 5% will become ill 200-300 R 600 15-30 % may Die 50 % may Die Radiation, Annual Dose Between 320 – 360 mr/yr May Nausea Vomit within 4 hours Nausea Vomit Quickly 30-50 % die no medical 95-100 % die with no medical Dose Limits for Emergency Workers • • Rem 5 – • 10 • 25 – >600 >90 % May Die All die in 2 weeks or sooner with no medical • >25 – • Condition General monitoring (no life safety involved) Protection of a large population Life saving (once in a lifetime) Life saving (authorization required) Source: U.S. EPA 400 1994 Toxic Industrial Chemicals (TICs) • TICs are chemicals that are manufactured, stored, transported, and used throughout the world. – Routes of Exposure – ALL – Toxicity • Can be chemical hazards (e.g., carcinogens, reproductive hazards, corrosives, or agents that affect the lungs or blood) or • physical hazards (e.g., flammable, combustible, explosive, or reactive). Chemical Hazard Classes FY 2000 Most Common Chemicals involved in Causing Deaths, Injuries, or Evacuations Chemical Name Chemical Name Chemical Name Chemical Name Ammonia Freon Heptanoic Acid Perchloroethylene Chlorine Sulfur Dioxide Hydrazine Sodium Hypochlorite Hydrogen Chloride Hydrofluoric Acid Hydrogen Cyanide Asbestos Sulfuric Acid Carbon Monoxide Malathion Ethylene Glycol Mercury Formaldehyde Methacrylic Acid Ethylene Oxide Sodium Hydroxide Hydrogen Sulfide Methanol PCBs Phosphoric Acid Mercaptans Phenol Propylene Glycol Acetone Benzene Thioglycol Bromine Butadiene Chromic Acid Sodium Ethanol Radioactive Materials Oxides of Nitrogen Based on reports to ATSDR from the National Response Center. No rank order intended What are the potential “TIC” Threats? • Use as a WMD / Weapon • Accidental release (Haz Mat) – Total for 2006 = 36,855 (NRC) • Environmental contaminant during and following natural disaster (i.e. Katrina) Chemicals in Transport • Roads • Rails • Water Graniteville, SC. (Jan. 2005) Chlorine gas •9 fatalities •554 treated at hospitals •75 admitted •5,400 evacuated •$6.9 million property damage Incendiaries \ Explosives Principles of Radiation & Chemical Safety • Selection and use of proper PPE • Use available shielding – Sheltering, • Use nearby buildings and structures • Even a vehicle offers some shielding Potential Public Health Issues Following a Major WMD \ Haz Mat Event • Emergency Support Function #8 includes: – – – – – – – – – – Assessment of Health and Medical needs, Medical Care, Equipment and Supplies Victim evaluation Food and Drug safety Worker (Responder) Health / Safety Radiological, Chemical and Biological Hazards Public Health Information Potable Water / Wastewater & Solid Waste management Health Surveillance Victim Identification and Mortuary Services EH Issues at “Special Concerns” Response • Health and Safety information regarding: Airborne contaminants (may be intentional) Chemicals Radiological Biological Worker Safety Contaminated waters Food and Water Safety Waste Management • EH Issues at “Special Concerns” Response • Environmental assessment activities • Monitoring, Sampling and Inspection plan, development and approval • Site Safety and Re-entry sampling • Food / Water safety inspections • Epidemiology activities – Data collection and management – Mapping and Long-term trend analysis • Community Education, Public Health Information What do the Responders and Public Need to Know “ASAP”? • What is the agent, • What are its hazards, • How to protect themselves – Stay upwind of vapors, (Sheltering and or Evacuations,) – Stay out of liquids and dust (what to be on the lookout for), • What to do if they are exposed, • Who to contact for more information. Initial Response Activities • Initiate Contamination Control Immediately – Restrict access to contamination, – Assure Decontamination activities conducted • Responders • victims Contamination Control and Decontamination • Advise responders and victims on initial decontamination • External contamination can be reduced 80-90% by removal of outer clothing • Washing the contaminated area with soap and water very effective • Ensure all contaminated tools, clothing, equipment & other material that can’t be decontaminated are bagged, tagged & stored for later disposition • Be prepared to refer questions on the contamination & control of exposed individuals to the “experts”, Examples of Local Environmental Health Response •Emergency Response activities & decision making, –Hazard identification and environmental monitoring, –Inform responders and public about protective actions needed, –Assist implementation of evacuation or Shelter in Place instructions –Assure regulatory compliance, •Assist with distribution of prophylaxis, Remember – Front Line Response Begins at the Local Level What do EH Practitioners bring to a response that is unique? • Possess a Broad Science Base • Understand Environmental Systems • Working Field Familiarity • Operational Surveys of Environmental Systems • Recognize Problems and Vulnerabilities • Influence the Operation of the System Public Health Issues Following a Major WMD \ Haz Mat Event Initial Response (Early Phase: 1-7 Days) • Sheltering, • Medical Care, including prophylaxes, • Monitoring and Decontamination of Responders and Victims, • Environmental Contamination, monitoring and control, • Handling & disposition of potentially-contaminated remains, • Hazardous and solid (liquid) waste management, • Infrastructure disruption – power outages, communication systems, water supply, waste water, food safety, others, Public Health Issues Following a Major WMD \ Haz Mat Event Intermediate Phase: Weeks to Months Recovery Phase: Months to Years – Relocation of populations – Agricultural products, as crops and in transit – Contaminated air plume and later resuspension of debris – remediation of land, waters and property – Health surveillance of exposed populations – Response planning – Mitigation of Hazards Resources available (free from CDC) HSDB Other Information Resources World Wide Web Partner Agencies • 911 • County Emergency Management • Law Enforcement • Fire \ EMS • Hazmat • Local Health Department • Local Hospitals • Other 1st Responders • Regional WMD\Haz Mat Teams, • State EOC \ Warning Point • Federal Bureau of Investigation State & Regional Response Resources • Air National Guard, Weapons of Mass Destruction Civil Support Teams (WMDCST), • State Department of Health – Radiation Safety • Environmental Protection, ERT • State Emergency Management – EMAC, the Emergency Management Assistance Compact, CDC Emergency Assistance 24 \ 7 Emergency Operation Center #770-488-7100 • • • Technological Disasters: - Radiation - Hazardous chemicals - Oil - Biologics Natural Disasters: - Hurricanes - Severe weather - Earthquakes - Volcanic eruptions - Floods - Extreme heat/cold Terrorism: - Biologic - Radiological - Chemical CDC Emergency Assistance • CDC Teams – Identify agent rapidly – Determine exposure distribution – Evaluate long-term health implications – Identify worried well • National Center for Environmental Health Laboratory Response Team – Support collection of clinical samples – 15 min response, 1 hr arrival at CDC – Shipping/tracking information – Work w/ Rapid Response lab on analysis Federal Notification, Response and Coordination • National Response Center (800-424-8802) – FBI, Federal Lead Agency if Terrorism / WMD incident • Resources include HMRT etc. – EPA is Federal Lead Agency for Environmental Recovery Phase • On Scene Coordinator • Remediation funds available via OSC Remember All disasters are local and require “local coordination” Strong federal “leadership” will be evident. Special Concerns - Exercise • There has been a response, in your community, to a large family planning clinic where a package has puffed out a cloud of unknown powder. Contained in the package is a letter indicating that the clinic staff will now die for their sins. A few of the clinic staff are beginning to complain of respiratory distress etc. 1. Based on your training and experience, what roles could\should you play, (e.g., 1st responder, environmental assessment, EOC liaison, etc?) 2. Assuming that role, what would be your next steps? 3. In that role, what information do you need? 4. Who would you be working with? 5. Where in the ICS would you likely be working?