Biochemistry "Hybrid" (CHEM XL 153A)
Tuesday and Thursday 7:00-10:00 PM
August 3 through September 9, 2004
Instructor:
Dr. Noel Sturm, (310) 243-3383
E-Mail:
noel@chemistry.csudh.edu (24/7)
Course Organization and Policies:
1.
Course Format: Students will go through the lecture material in an online setting
meeting on campus once per week (see syllabus for specific dates) to discuss lecture
material, go over homework, ask questions and take examinations.
2.
"Chat" Room: The once per week virtual meeting (see syllabus for specific dates) will
allow the instructor to discuss lecture material and give students a chance to ask
questions. Attendance in the chat room is mandatory.
If you are familiar with IRC and have a preferred client, we are in room #Chemistry on server
irc.PilotAge.com.
To join our Biochem Chat Room go to http://www.gravitywaves.com/chemistry:
1) Click on the "Chat" Room icon.
2) Enter in your first name and press LOGIN.
3) Chat by clicking on, then typing into, the blank line at the bottom of the chat window.
4) Exit by closing this Window.
5) Please tell us if you have any problems accessing the chat room, Click Here
3.
Text: "Lehninger Principles of Biochemistry", David L. Nelson & Michael M. Cox,
Fourth Edition, 2005, FREEMAN Worth Publishers.
4.
Lecture Notes with Audio: The lecture notes are available on-line, arranged via lecture
topic, at: http://www.gravitywaves.com/chemistry. Examination questions will be
derived directly from lecture material.
5.
Examinations: There will be two examinations (see syllabus for specific dates) each
worth 100 points. Absolutely NO make-up exams will be given.
6.
Quizes: There will be a ten minute quiz (On Campus meeting days) from 7:05 to 7:15
PM. These quizes will total 100 points towards the final grade (equal to one exam grade).
No make-up quizes will be given, students arriving late will receive a zero for that days
quiz.
7.
Final Exam: The final exam is on Thursday, September 9th, 7:00-10:00 PM.
8.
Learning Objectives: The objectives are designed to help you focus and assimilate the
material presented.
9.
The Goal of this course is to understand and outline Proteins, Enzymes, Membranes and
the Carbohydrate Metabolic Pathways.
10.
Grading Criteria: Letter grades will be assigned on the following basis. Grades are not
curved.
Daily Quizes
100 pts
Two Exams @100 pts
200 pts
Final Exam
100 pts
Total
400 pts
Grade
A
B+
BC
D+
F
Percentages
100-91
88-87
80-79
76-71
68-67
59-0
Grade
AB
C+
CD
Percentages
90-89
86-81
78-77
70-69
66-60
11.
Case Studies/Clinical Correlates: Related directly to the general biochemical
principles being taught are intended to give "real-life" significance to the biochemistry
experience. List of Case Studies: Aspirin Poisoning, Lactase Deficiency, Myocardial
Infarction, Familial Hypercholesterolemia, Insulin Dependent Diabetes Mellitus (IDDM)
12.
Course Description: The chemistry of amino acids and proteins; the chemistry and
metabolism of carbohydrates and lipids; energetics in living systems. The course is
taught with a medical emphasis and covers peptides, proteins, myoglobin/hemoglobin,
enzymes, and metabolism, as well as, clinical correlates and case studies.
13.
Academic Integrity Statement: A university is a community of learners bonded
together by the search for knowledge; the pursuit of personal, social, cultural, physical,
and intellectual development; and the desire for the liberating effects of an advanced
education. Academic integrity is of central importance in the university community and
involves committed allegiance to the values, the principles, and the code of behavior held
to be central in that community. Integrity concerns honesty and implies being truthful,
fair, and free from lies, fraud and deceit.
Tentative Syllabus
Lecture Title
Chemistry of Life / The Cell
Molecules of Life / Water
Acidosis/Alkalosis (Case Study 1)
Amino Acids/Proteins
Dates
T 8/3, On Campus*, 7:00 to 10:00PM
Th 8/5, On Campus, 7:00 to 10:00PM
Proteins: Globular, Membrane, Fibrous
Proteins-Structual
Exam 1
T 8/10, Virtual Meeting**, "Chat" Room
7:00-10:00PM
Th 8/12, On Campus, 7:00 to 10:00PM
Myoglobin/Hemoglobin
Gas Transport / Antibodies and Antigens
Enzymes: Catalysis and Kinetics
(Case Study 2)
Enzymes: Isozymes and Regulation
Enzyme Mechanisms-Serine Proteases
(Case Study 3)
T 8/17, Virtual Meeting, "Chat" Room 7:00
10:00PM
Th 8/19, On Campus, 7:00 to 10:00PM
Nucleotides / Lipids
Membranes I & II
Exam 2
T 8/24, Virtual Meeting, "Chat" Room 7:0010:00PM
Th 8/26, On Campus, 7:00 to 10:00PM
Overview of Carbohydrate Metabolism
Intro To & Thermodynamics in Metabolism
The Vitamins of CHO Metabolism
Glycogen
Glycolysis
T 8/31, Virtual Meeting, "Chat" Room 7:0010:00PM
Th 9/2, On Campus, 7:00 to 10:00PM
Citric Acid Cycle
Electron Transport
Final Exam
T 9/7, Virtual Meeting, "Chat" Room 7:0010:00PM
Th 9/9, On Campus, 7:00 to 10:00PM
* Young Hall, CS 24
** "Chat" Room, http://www.gravitywaves.com/chemistry
Lehninger Reading List
Lecture Title
Chemistry of Life / The Cell
Molecules of Life / Water
Chapter
1(pgs. 12-15)
2(pgs. 47-56)
Acidosis/Alkalosis (Case Study 1)
Amino Acids/Proteins
2(pgs. 60-70)
3(pgs. 75-106)
Proteins: Globular, Membrane, Fibrous
Proteins-Structural
4(pgs. 116-151)
Myoglobin/Hemoglobin
Gas Transport / Antibodies and Antigens
5(pgs. 158-185)
Enzymes: Catalysis and Kinetics (Case Study 2)
Enzymes: Isozymes and Regulation
Enzyme Mechanisms-Serine Proteases
Nucleotides / Lipids (Case Study 3)
Membranes I & II
6(pgs. 191-232)
8(pgs. 273-296)
10(pgs. 343-348)
10(pgs. 348-356)
11(pgs. 370-415)
Overview of Carbohydrate Metabolism
Intro To & Thermodynamics in Metabolism
The Vitamins of CHO Metabolism
13(pgs. 490-515)
7(pgs. 238-260)
Glycogen
Glycolysis
14(pgs. 534-536)
15(pgs. 562-569)
14(pgs. 522-542)
Citric Acid Cycle
Electron Transport
16(pgs. 602-622)
19(pgs. 691-721)