Curriculum Vitae
Name:
Sex:
Date of Birth:
Citizenship:
Lu-Hai Wang
Male
September 2, 1947, Taiwan, Republic of China
R.O.C./U. S.
Education
1966-1970
National Taiwan University. B.S. in Zoology.
1971-1976
University of California at Berkeley. Ph.D. in Molecular Biology.
Position and Scientific Experience
1966-1970
Undergraduate, College of Sciences, National Taiwan University, Taiwan
(Zoology, Chemistry).
Summer 1971
Research Assistant, Laboratory of Dr. Richard Calendar, Department of
Molecular Biology, University of California at Berkeley: growth,
quantitative assay and purification of bacteria and bacteriophages P2 and
P4.
Graduate Research, Department of Molecular Biology, University of
California at Berkeley.
1971-1976
1972-1976
Graduate Student, Laboratory of Dr. Peter Duesberg, Department of
Molecular Biology, University of California at Berkeley. Genetic structure
and enzymology of RNA tumor viruses.
1976-1977
Postgraduate Research Molecular Biologist, Laboratory of Dr. Peter
Duesberg. Sequences and functions of avian tumor virus RNAs;
mechanism of viral recombination.
1977-1979
Postdoctoral Fellow, Laboratory of Dr. Hidesaburo Hanafusa, The
Rockefeller University, New York. Sequence analysis of avian sarcoma
viruses generated by recombination between transformation-defective
mutants and normal cellular sequences. Study of the relationship and origin
of transforming genes of different strains of avian sarcoma viruses.
1979-1985
Assistant Professor, The Rockefeller University, New York. Sequences
and functions of retroviral and cellular oncogenes; mechanism of
recombination between viral and cellular sequences; viral RNA
transcription and processing.
1985-1988
Associate Professor, The Rockefeller University, New York. Function of
viral and cellular oncogenes; transforming potential of growth factor
1
receptor genes; viral RNA transcription and processing.
1988-1992
Associate Professor (with tenure), Department of Microbiology, Mount
Sinai School of Medicine, NYC, Expression and function of viral and
cellular oncogenes; Transforming and tumorigenic potential of growth
factor receptor genes; Mechanism of cell transformation, cancer
development and progression. Signal transduction of protein tyrosine
kinases and their messengers. Molecular basis of cancer cell survival,
invasion and drug resistance. Development of targeted cancer therapy.
1992- present
Professor (with tenure), Department of Microbiology, Mount Sinai
School of Medicine
Professor, Derald H. Ruttenberg Cancer Center, Mount Sinai School of
Medicine
Professor, Department of Oncological Science, Mount Sinai School of
Medicine
Distinguished Investigator and Director, Division of Molecular and
Genomic Medicine, National Health Research Institute, Taiwan
Professor, National Central University
Acing Director, Immunology Center, NHRI
Adjunct professor, National Central University
Joint professor, Chinese Medical University
Joint Professor National Tsain Hua University
1999-2004
2004- present
2008- present
2009 Feb 2009 April-July
2008 2010 2011Honors
1969
1977
1979
1979
1979-1984
1996-1997
19982010
Coupon Award from National Taiwan University for Outstanding
Undergraduate Achievement.
Damon Runyon-Walter Winchell Cancer Fund Postdoc. Fellowship.
Scholar of American Leukemia Society (declined).
American Cancer Society Junior Faculty Award (declined).
Research Career Development Award (NIH).
President, Tri-state Chapter, Society of Chinese Bioscientists in America
Honorary Professor, Peking Union Medical College, China
Academician, Academia Sinica, Taiwan
Societies
American Society of Virology
American Society of Microbiology
AAAS
New York Academy of Sciences
Society of Chinese Biochemists in America (Life Member)
SCBA Bio/Pharm Division Member
Chinese Society of Cell and Molecular Biology, member and board
member, 2009Committees and Professional Activity
2
N.I.H. Ad Hoc Study Section and Site Visits:
Oct. 1984; Mar. 1985; May 1986; June 1989; Jan. 1995; Apr. 1995,
January 2002, August, 2002, March, 2004
American Cancer Society: Study Section Meetings
1986-1990
NIH Experimental Virology Study Section.
1989
Symposium organizer, “Retroviruses, Oncogenes and Growth Factors”
Rockefeller University, November 30, 1989
1990NIH Study Section Reviewers Reserve.
1986-1990
Editorial Board, Oncogene Research.
1993-1996
NIH Experimental Virology Study Section
1997
Symposium Chairperson, “Discovery of oncogenes: from
crossroads to the future”, May 7, 1997, Rockefeller University.
1997-2010
Editorial Board, Virology
1997
Symposium organizer, Annual meeting, Tri-State Chapter, SCBA
1997- 2001
Advisor Committee, DMGM, NHRI, Taiwan
2000Consultant, National Health Research Institute (NHRI), Taiwan
2000- 2002
Consultant, National Science Program in Pharmaceuticals and
Biotechnology, Taiwan
2001
National Science Foundation, Ad Hoc Grant Review
2001
Co-organizer for the 17th International Oncogene Meeting
2002
Wellcom Foundation, Ad Hoc Grant Review
2002
Symposium Speaker, Endo 2002, the 84th Annual Meeting of the
Endocrinology Society June 19-22, 2002
2002
Science Foundation Ireland, Ad Hoc Grant Review
2003- 2005
Chief Editor, Biotech and Pharma.Quarterly, SCBA
2004
Project Reviewer, U.S.-Israel Binational Science Foundation
2004- 2007
Consultant, Natl Research Program for Genomic Medicine, Taiwan
2009 Feb
Plenary speaker, 7th Chinese Society of Cell and Molecular Biology Symp.
2009 Board member, Chinese Society of Cell and Molecular Biology
2009
Program director, 2009 IFCB Intl Training Program in Cell & Molecular
Biology, June 15th to 26th, NHRI, Taiwan
PUBLICATIONS
1.
Wang, L.-H. and Duesberg, P. (1973). DNA polymerase of murine sarcoma-leukemia
virus: Lack of detectable RNase H and low activity with viral RNA and natural DNA
templates. J.Virol. 12:1512-1521.
2.
Wang, L.-H., and Duesberg, P. (1974). Properties and location of poly(A) in Rous sarcoma
virus RNA. J.Virol. 14:1515-1529.
3.
Duesberg, P.H., Kawai, S., Wang, L.-H., Vogt, P.K., Murphy, H.M., and Hanafusa, H.
(1975). RNA of replication-defective strains of Rous sarcoma virus. Proc.Natl.Acad.Sci.
USA 72:1569-1573.
4.
Wang, L.-H., Duesberg, P., Beemon, K., and Vogt, P.K. (1975). Mapping RNase
T1-resistant oligonucleotides of avian tumor virus RNAs:
Sarcoma-specific
3
oligonucleotides are near the poly(A) end and oligonucleotides common to sarcoma and
transformation-defection viruses are at the poly(A) end. J.Virol. 16:1051-1070.
5.
Wang, L.-H., Duesberg, P.H., Kawai, S., and Hanafusa, H. (1975). Location of
envelope-specific oligonucleotides on RNA of Schmidt-Ruppin Rous sarcoma virus: In
Comparative Leukemia Research 1975, Bibliotheca Haematologica, No. 43. Eds.
Clemmensen, J., and Yohn, D.S. Karger, Basel, 1976, pp.542-548.
6.
Duesberg, P.H., Wang, L.-H., Beemon, K., Kawai, S., and Hanafusa, H. (1975). Sequences
and functions of Rous sarcoma virus RNA. In Modern Trends in Human Leukemia II.
Eds. Neth, R., Mannweiler, K., and Gallo, R.C. Grune and Stratton, New York, pp.
327-339.
7.
Wang, L.-H., Duesberg, P.H., Kawai, S., and Hanafusa, H. (1976). Location of
envelope-specific and sarcoma-specific oligonucleotides on RNA of Schmidt-Ruppin
Rous sarcoma virus. Proc.Natl.Acad.Sci. USA 73:447-451.
8.
Wang, L.-H., Duesberg, P., Mellon, P., and Vogt, P. (1976). Distribution of
envelope-specific and sarcoma-specific nucleotide sequences from different parents in the
RNAs of avian tumor virus recombinants. Proc.Natl.Acad.Sci. USA 73:1073-1077.
9.
Duesberg, P.H., Wang, L.-H., Mellon, P., Mason, W.S., and Vogt, P.K. (1976). Towards a
complete genetic map of Rous sarcoma virus. In Proceedings of the ICN-UCLA
Symposium (1976) on Animal Virology. Eds. Baltimore, D., Huang, A., and Fox, C.F.
Academic Press, New York, pp. 107-125.
10.
Wang, L.-H., Galehouse, D., Mellon, P., Duesberg, P., Mason, W.S., Vogt, P.K.
(1977). Mapping oligonucleotides of Rous sarcoma virus RNA that segregate with
polymerase and group-specific antigen markers in recombinants. Proc.Natl.Acad.Sci.
USA 73:3952-3956.
11.
Duesberg, P.H., Wang, L.-H., Mellon, P., Mason, W.S., Vogt, P.K. (1977). The genetic
map of Rous sarcoma virus. In Genetic Manipulation as it Affects the Cancer Problem.
Eds. Schultz, F., and Brada, Z. Academic Press, New York, pp. 161-179.
12.
Wang, L.-H., Duesberg, P.H., Robins, T., Yokota, H., Vogt, P.K. (1977). The terminal
oligonucleotides of avian tumor virus RNAs are genetically linked. Virology 82:472-492.
13.
Wang, L.-H., Levinson, W. (1978). N-methyl Isatin B-thiosemicarbazon-copper complex
inhibits RNA-dependent DNA polymerase but not ribonuclease H of Rous sarcoma virus.
Bioinorganic Chemistry 8:535-540.
14.
Wang, L.-H., Halpern, C.C., Nadel, M., Hanafusa, H. (1978). Recombination between
viral and cellular sequence to generate transforming sarcoma virus. Proc.Natl.Acad.Sci.
USA 75:5812-5816.
15.
Wang, L.-H. (1978). The gene order of avian RNA tumor viruses derived from
biochemical analyses of deletion mutants and viral recombinants. Ann.Rev.Microbiology
4
32:561-592.
16.
Wang, L.-H., Karess, R., Moscovici, C., Hanafusa, H. (1979). Analysis of src gene of
recombinant viruses between transformation-defective mutant of Rous sarcoma virus and
normal quail cells. J. Virol. 32:546-556.
17.
Wang, L.-H., Snyder, P., Hanafusa, T., Moscovici, C., and Hanafusa, H. (1980).
Comparative analysis of cellular and viral sequences related to sarcomagenic cell
transformation. Cold Spring Harbor Symp. Quant. Biology 44:755-764.
18.
Hanafusa, T., Wang, L.-H., Anderson, S.M., Karess, R.E., Hayward, W.S., and Hanafusa,
H. (1980). Characterization of a new transforming gene of Fujinami sarcoma virus.
Proc.Natl.Acad.Sci. USA 77:3009-3013.
19.
Wang, L.-H., Snyder, P., Hanafusa, T., Hanafusa, H. (1980). Evidence for the common
origin of viral and cellular sequences involved in sarcomagenic transformation. J.Virol.
35:52-64.
20.
Hanafusa, H., Wang, L.-H., Hanafusa, T., Anderson, S.M., Karess, R.E., and Hayward,
W.S. (1980). The nature and origin of the transforming gene of avian sarcoma viruses. In
Animal Virus Genetics, Eds. Fields, B.N., Jaenish, R., and Fox, C.F. Academic Press,
New York, Vol. 18, pp. 483-497.
21.
Wang, L.-H., Feldman, R., Shibuya, M., Hanafusa, H., Notter, M.F.D., and Balduzzi, P.C.
(1981). Genetic structure, transforming sequence and gene product of avian sarcoma virus
UR1. J.Virol. 40:258-267.
22.
Wang, L.-H., and Stacey, D. (1982). Participation of subgenomic messenger RNAs in
recombination. J.Virol. 41:919-930.
23.
Wang, L.-H., Hanafusa, H., Notter, M.F.D., and Balduzzi, P.C. (1982). Genetic structure
and transforming sequence of avian sarcoma virus UR2. J.Virol. 41:833-841.
24.
Feldman, R.A., Wang, L.-H., Hanafusa, H., and Balduzzi, P.C. (1982). Avian sarcoma
virus UR2 encodes a transforming protein which is associated with a unique protein kinase
activity. J.Virol. 42:228-236.
25.
Neel, B.G., Wang, L.-H., Mathey-Prevot, B., Hanafusa, T., Hanafusa, H., and Hayward,
W.S. (1982). Isolation of 16L virus: A rapidly transforming sarcoma virus from an avian
leukosis virus-induced sarcoma. Proc.Natl.Acad.Sci. USA 79:5088-5092.
26.
Shibuya, M., Wang, L.-H., and Hanafusa, H. (1982). Molecular cloning of Fujinami
sarcoma virus genome and its comparison with sequences of other related transforming
viruses. J.Virol. 42:1007-1016.
27.
Wang, L.-H., Beckson, M., Anderson, S., and Hanafusa, H. (1984). Identification of the
viral sequence required for the generation of recovered avian sarcoma viruses (rASVs) and
5
characterization of a series of replication-defective rASVs. J.Virol. 49:881-891.
28.
Wang, L.-H., Edelstein, B., and Mayer, B.J. (1984). Induction of tumors and generation of
recovered sarcoma viruses (rASVs) by, and mapping of deletions in, two molecularly
cloned src deletion mutants. J.Virol. 50:904-913.
29.
Neckameyer, W.S., and Wang, L.-H. (1984). Molecular cloning of avian sarcoma virus
(ASV) UR2 and comparison of its transforming sequence with those of other ASVs.
J.Virol. 50:914-921.
30.
Neckameyer, W.S., and Wang, L.-H. (1985). Nucleotide sequence of avian sarcoma virus
UR2 and comparison of its transforming gene with other members of tyrosine protein
kinase oncogene family. J.Virol. 53:879-884.
31.
Parvin, J.D., and Wang, L.-H. (1984). Mechanism for the generation of src-deletion
mutants and recovered sarcoma viruses: Identification of viral sequences involved in src
deletions and in recombination with c-src sequence. Virology 138:236-245.
32.
Wang, L.-H. (1985). Deletion in the 3' pol sequence correlates with aberration of RNA
expression in certain replication-defective avian sarcoma viruses. J.Virol. 54:446-459.
33.
Dutta, A., Wang, L.-H., Hanafusa, T., and Hanafusa, H. (1985). Partial nucleotidesequence
of Rous sarcoma virus-29 provides evidence that the original Rous sarcoma virus was
replication- defective. J.Virol. 55:728-735.
34.
Neckameyer, W.S., Shibuya, M., Hsu, M.-T., and Wang, L.-H. (1986). Proto-oncogene
c-ros codes for a molecule with structural features common to those of growth factor
receptors and displays tissue-specific and developmentally regulated expression.
Mol.Cell.Biol. 6:1478-1486.
35.
Soong, M.-M., Iijima, S., and Wang, L.-H. (1986) Mechanism of c-src transduction by a
src deletion mutant of Rous sarcoma virus. J.Virol. 59:556-563.
36.
Matsushime, H., Wang, L.-H., and Shibuya, M. (1986). Human c-ros-1 gene homologous
to v-ros sequence of UR2 sarcoma virus encodes for a transmembrane receptor-like
molecule. Mol.Cell.Biol. 6:3000-3004.
37.
Wang, L.-H. (1988). The ros oncogene. In Oncogene Handbook. E.R. Reddy, T. Curran,
A. Skalka (eds.) The ros oncogene, Chap. 9, p135-148.
38.
Wang, L.-H. (1987). The mechanism of c-src transduction by avian retroviruses. Mutation
Research 186:135-147.
39.
Wang, L.-H. and H. Hanafusa. (1988) The avian sarcoma viruses. Avian sarcoma viruses.
Virus Research 9:159-203.
40.
Ellis, L., Morgan, D.O., Jong, S.-M., Wang, L.-H., Roth, R.A., and Rutter, W.J. (1987).
6
Heterologous transmembrane signaling by a human insulin receptor/v-ros hybrid in CHO
cells. Proc.Natl.Acad.Sci. USA 84:5101-5105.
41.
Ellis, L., Morgan, D.O., Clauser, E., Reddy, M., Jong, S.-M., Wang, L.-H., Roth, R., and
Rutter, W.J. (1986). Mechanism of receptor-mediated transmembrane communication. In
Molecular Biology of Homo sapiens, Cold Spring Harbor Symposium Quantitative
Biology, Vol. 51, Cold Spring Harbor Laboratory, pp 773-784.
42.
Jong, S.-M., and Wang, L.-H. (1987). The transforming protein P68gag-ros of avian sarcoma
virus UR2 is a transmembrane protein with the p19 portion protruding extracellularly.
Oncogene Research, 1:7-21.
43.
Wang, L.-H., Iijima, I., Dorai, T., and Lin, B. (1987). Regulation of the expression of
proto-oncogene c-src by alternative RNA splicing in chicken skeletal muscle. Oncogene
Research, 1:43-59.
44.
Wang, L.-H., Lin, B., Jong, S.-M., Dixon, D., Ellis, L., Rutter, W.J. and Roth, R. (1987).
Activation of the transforming potential of human insulin receptor gene.
Proc.Natl.Acad.Sci. USA 84:5725-5729.
45.
Shibuya, M., Matsushime, H., Yamazaki, H., Wang, L.-H., Fukui, Y., Ueyama, Y.,. and
Tamaoki, N. (1987) Analysis of structure and activation of some receptor-type tyrosine
kinase oncogenes. In Oncogenes and Cancer, S.A. Aaronson et al. (eds.). Japan Sci. Sco.
Press, Tokyo, pp 195-202.
46.
Levy, J.B., Dorai, T., Wang, L.-H., and Brugge, J.S. (1987). The structurally distinct form
of pp60c-src detected in neuronal cells is encoded by a unique c-src mRNA. Mol.Cell.Biol.
7:4142-4145.
47.
Sudol, M., Kieswetter, C., Zhao, Yu-Hang, Dorai, T., Wang, L.-H., and Hanafusa, H.
(1988). Nucleotide sequence of a cDNA for the chick yes proto-oncogene: comparison
with the viral yes gene. Nucleic Acids Res. 16:9876.
48.
Rutter, W.J., Morgan, D., Ebina, Y., Wang, L.-H., Roth, R., and Ellis, L. (1988).
Membrane linked insulin receptor tyrosine kinase stimulates the insulin specific response.
Proc.Intl.Conf. on Insulin Action and Diabetes. Calgary, March 26-27, 1987. H.J. Goren,
(eds.) Raven Press
49.
Fukui, Y., Kornbluth, S., Jong, S.-M., Wang, L.-H., and Hanafusa, H. (1989)
Phosphotidylinositol kinase type I like activity associated with various oncogene products.
Oncogene Research 4:283-292.
50.
Dorai, T., and Wang, L.-H. (1990) An alternative non-tyrosine protein kinase product of
the c-src gene in chicken skeletal muscle. Mol. & Cell. Biol. 10:4068-4079.
51.
Boulton, T.G., Gregory, J.S., Jong, S.-M., Wang, L.-H., Ellis, L., and Cobb, M.H. (1990)
Evidence for insulin-dependent activation of S6 and microtubule-associated protein-2
7
kinases via a human insulin receptor/v-ros hybrid. J.Biol.Chem. 265:2713-2719.
52.
Jong, S.-M.J., and Wang, L.-H. (1990) The role of gag sequence in the biochemical
properties and transforming activity of the avian sarcoma virus UR2-encoded gag-ros
fusion protein. J.Virol. 64:5997-6009.
53.
Jong, S.-M.J., and Wang, L.-H. (1991) Two point mutations in the transmembrane domain
of P68gag-ros inactive its transforming activity and cause a delay in membrane association.
J.Virol. 65:180-189.
54.
Chen, J., Heller, D., Poon, B., Kang, L. and Wang, L.-H. (1991) Proto-oncogene c-ros
codes for a transmembrane tyrosine protein kinase sharing sequence and structural
homology with sevenless protein of Drosophila melanogaster. Oncogene 6:257-264.
55.
Poon, B., Dixon, D., Ellis, L., Roth, R.A., Rutter, W.J., and Wang, L.-H. (1991) Molecular
basis for activation of tumorigenic potential of a gag-human insulin receptor fusion gene.
Proc.Natl.Acad.Sci. USA 88:877-881.
56.
Dorai, T., Levy, J.B., Kang, L., Brugge, J.S., and Wang, L.-H. (1991) Analysis of cDNAs
of the proto-oncogene c-src: heterogeneity in 5' exons and possible mechanism for the
genesis of the 3' end of v-src. Mol.Cell.Biol. August Issue, 11:4165-4176.
57.
Liu,D., Chen, E., Poon, B., Rutter, W.J., and Wang, L.-H. (1992) Enhancement of
Transforming potential of human insulin-like growth factor I receptor by N-terminal
truncation and fusion to avian sarcoma virus UR2 gag sequence. J.Virology 66:374-385.
58.
Jong, S.-M. J., Dorai, T., Wang, L.-H. (1992) Transforming properties and substrates
specificities of the protein tyrosine kinase oncogenes ros, src and their recombinants. J.
Virol. 66:4909-4918.
59.
Liu, D., Rutter, W. J. and Wang, L.-H. (1992) Modulatory effect of the extracellular
sequence of the human insulinlike growth factor I receptor on its transforming and
tumorigenic potential. (1992) J. Virol. 67:9-18.
60.
Liu, D., Zong, C. S. and Wang, L.-H. (1993) Distinctive effect of the carboxylterminal
sequence of the insulinlike growth factor I on its signalling functions. J. Virol.
67:6835-6840.
61.
Zong, C. S., Poon, B., Chen, J. and Wang, L.-H. (1993) Molecular and biochemical
basis for activation of the transforming potential of the proto-oncogene c-ros. J. Virol.
67:6453-6462.
62.
Chen, J., Hanafusa, T. and Wang, L.-H. (1994) Alanine to glycine mutation in the
putative catalytic loop confers temperature sensitivity on ros, insulin receptor and
insulinlike growth factor I receptor protein tyrosine kinases. Proc. Natl. Acad. Sci. U. S.
A. 91:321-325.
8
63.
Chen, J. Zong, C. S. and Wang, L.-H. (1994) Tissue and epithelial cell-specific expression
of chicken proto-oncogene c-ros in several organs suggests that it may play roles in their
development and mature functions. Oncogene 9: 773-780.
64.
Liu, D. and Wang, L.-H. (1994) Oncogene, protein tyrosine kinases and signal
transduction.J. of Biomedical Sci. 1: 65-82.
65.
Zong, C. S. and Wang, L-H. (1994) Modulatory effect of the transmembrane domain of
oncogene ros protein kinase on its biological function and substrate interaction. Proc.
Natl. Acad. Sci. U.S.A. 91:10982-10986.
66.
Wang, L.-H. (1995) c-Ros protein tyrosine kinase. In The Protein Tyrosine Kinase
Factsbook. Ed. D. G. Hardie. pp 202-204. Academic Press.
67.
Chen, J., Tong, J., Tanaka-Sukegawa,I., and Wang,L.-H. (1995) Cloning and functional
characterization of the chicken c-ros promoter. Cell Growth& Differentiation 6: 15231530.
68.
Jiang,Y., Chan,J.-K., Zong, C.S. and Wang, L.-H. (1996) Effect of tyrosine mutations
on the kinase activity and transforming potential of an oncogenic human insulin-like
growth factorI receptor J. Biol. Chem. 271:160-167.
69.
Xiong, Q., Chan, J. L.-K., Zong, C. S. & Wang, L.-H. (1996) Two chimeric receptors
of epidermal growth factor receptor and c-Ros that differ in their transmembrane domains
have opposite effects on cell growth. Mol. & Cell. Biol. 16: 1509-1518.
70.
Xiong, Q., Guo, Xiaojun, Zong, C. S., Jong, S.-M. J., Jiang, Y., Chan, J. and Wang, L.-H.
(1996) Cloning and expression of chicken protein tyrosine phosphatase gamma.
Biomedical J. 3:266-274.
71.
Zong, C. S., Chan, J. L,-K., Yang, S.-K. and Wang, L.-H.(1997) Mutation of Ros
differentially effecting signal transduction pathways leading to cell growth and
transformation. J. Biol. Chem. 272:1500-1506.
72.
Chan J. L.-K., Lai. M. and Wang. L.-H.(1997) Effect of dimerization on signal
transduction and biological function of oncogenic Ros, insulin and insulin-like growth
factor I receptors. J. Biol. Chem. 272:146-153.
73.
Chen. J., Sadowski, H., Kohanski, R. and Wang, L.-H.(1997) Stat5 is a physiological
substrate of the insulin receptor.Proc. Natl. Acad. Sci. U.S.A. 94:2295-2300.
74.
Li, W., Jiang, Y.-X., Zhang, J., Kapoor, V. Pierce, J. H. and Wang, L.-H. (1998) Protein
kinase C delta is an important molecule in insulin-like growth factor I receptor-mediated
cell
transformation but not mitogenicity. Mol. Cell Biol. 18:5888-5898.
75.
Zong, C. S., Zeng, L., Sadowski, H. and Wang, L.-H. (1998) Stat3 plays an important role
in oncogenic Ros and insulin growth factor I receptor-mediated cell transformation. J.
9
Biol. Chem.273:28065-28072.
76.
Soon, L., Flechner, L., Gutkind, J. S., Wang, L.-H., Baserga, R., Pierce, J.H. and Li, W. (1999)
Insulin-like growth factor I synergizes with interleukin 4 for hematopoietic cell proliferation
independent of insulin receptor substrate expression. Mol. Cell Biol. 19:3816-3828.
77.
Zong, C. S., Chan, J., Levy, D. E., Horvath, C., Sadowski, H. B. and Wang, L.-H. (2000).
Mechanism of Stat3 activation by insulin-like growth factor I receptor. J. Biol. Chem.
275:15099-15105.
78.
Zeng, L., Sachdev, P., Yan, L. Trenkel, T. and Wang. L.-H. (2000) Vav3 mediates signaling of
receptor tyrosine kinases, modulates cell morphology and has cell transforming potential. Mol.
Cell. Biol. 20:9212-9224.
79.
Nguyen, T. K. and Wang. L.-H. (2000) Differential requirement of the MAP kinase and PI3
kinase pathways for transformation of epithelial cells by src versus oncogenic insulin and
IGF-1 receptors. Oncogene 19:5385-5397.
80.
Hermanto, U., Zong, C. S. and Wang, L.-H. (2000) Inhibition of MEK selectively inhibits cell
proliferation in human breast cancer cells displaying enhanced IGF-1-mediated MAP kinase
activation. Cell Growth & Diff. 11:655-664.
81
Sachdev, P., Jiang, Y, Li, W., Miki, T., Maruta, H., Nur-E-Kamal, M.S.A. and Wang, L.-H.
(2001) Differential requirement for Rho family GTPases in oncogenic IGF-1
receptor-induced cell transformation. J Biol. Chem. 276:26461-26471.
82
Sadowski, C. L., Wheeler, T. T., Wang, L.-H. and Sadowski, H.B. (2001) Direct regulation
of IGF-1 and SOCS-2 gene expression by growth hormone in C2C12 skeletal muscle cells.
Endocrinology 142:3890-3900.
83
Sadowski, C. L., Choi, T.-S., Le, M., Wheeler, T. T., Wang, L.-H. and Sadowski, H. B.
(2001) Insulin induction of SOCS-2 and SOCS-3 mRNA expression in C2C12 skeletal
muscle cells is mediated by Stat5. J. Biol. Chem. 276:20703-20710.
84.
Sun, A. S., Yeh, H-C., Wang, L.-H., Huang, Y. P., Maeda, H. Pivazyan, A., Hsu, C., Lewis,
E. R., Bruckner, H. W. and Fasy, T. M. (2001) Pilot study of a specific dietary supplement
in tumor bearing mice and in stage IIIB and IV Non-small cell lung carcinoma patients.
Nutrition and Cancer 39:85-95.
85
Hermanto, U., Zong, C. S. and Wang, L.-H.(2001) ErbB2 overexpressing human
mammary cancer cells display an increased requirement for the phosphatidylinositol
3-kinase signaling pathway in anchorage independent growth. Oncogene 20:7551-7562.
86
Hermanto, U., Zong, C.S. and Wang, L.-H. (2002) RACK1, an insulin-like growth factor I
receptor-interacting protein, regulates IGF-I-dependent focal adhesion signaling, cell
proliferation and colony formation. Mol. Cell. Biol. 22: 2345-2365.
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Nguyen, T., Zong, C.S., Uttamsingh, S., Sachdev, P., Bhanot, M., Le, M., Chan, J. L.-K.
and Wang, L.-H. (2002).The role of phosphatidylinositol 3-kinase, Rho family GTPases
and Stat3 in ros-induced cell transformation. J. Biol. Chem. 277:11107-11115.
88.
Sachdev, P., Zeng, L. and Wang, L.-H. (2002). Distinct role pf phosphotidylinositol
3-kinase and Rho family GTPases in Vav3-induced cell transformation, cell motility, and
morphological changes. J. Biol. Chem. 277:17638-17648.
89.
Le, Maithao N., Kohanski, Ronald.A., Wang, Lu-Hai and Sadowski, Henry (2002). Dual
mechanism of signal transduccer and activator of transcription 5 (Stat5) activation by the
insulin receptor. Molecular Endocrinology 16:2764-2779.
90.
Uttamsingh, Shailaja, Zong, Cong S. and Wang, Lu-Hai (2003). Matrix-independent
activation of PI3 kinase, Stat3 and cyclin A-associated Cdk2 is essential for anchorage
independent growth of v-Ros transformed chicken embryo fibroblasts. J. Biol. Chem.
278:18798-18810.
91.
Wang, Lu-Hai (2004) Molecular signaling regulating anchorage-independent growth of
cancer cells. The Mount Sinai J. of Medicine 71:361-367.
92.
Lopewz-Bergami, P., Hasen H., Bhoumik, A, Zhang, W., Wang L.-H., and Ronai, Z.
(2005) Receptor for RACK1 mediates activation of JNK by protein kinase C. Mol. Cell
19:309-320.
93.
Zhang, W., Zong, C. S., Hermanto, U., Lopez-Bergami, P., Ronai, Z. and Wang, L.-H.
(2005) RACK1 recruits STAT3 specifically to insulin and IGF-1 receptors for activation,
which is important for regulating anchorage independent growth. Mol. Cell Biol.
26:413-424.
94.
Yio, X., Diamond, M., Zhang, J.-Y., Weinstein, H., Wang, L.-H., Werther, L. and
Itzkowitz, S. (2006) Trefoil factor family-1 mutations enhance gastric cancer cell invasion
through distinct signaling pathways. Gastroenterology 130:1696-706.
95.
Dong, Z., Liu, Y., Lu, S., Wang, A., Lee, K., Wang, L.-H., Revdo, M. and Lu, S. (2006)
Vav3 oncogene is overexpressed and regulates cell growth and androgen receptor activity
in human prostate cancer. Mol Endo. 20:2315-2325.
96.
Cheng, G. Z., Chan, J., Sun, C.D., Wang, Q., Zhang, W. and Wang, L.-H. (2007). Twist
transcriptionally upregulates AKT2 in invasive breast cancer cells leading to increased
migration and survival. Cancer Research 67:1979-87.
97.
Wang, L.-H., Chan, J. L.-K. and Li, W. (2007) Rapamycin together with herceptin
significantly increased anti-tumor efficacy compared to either alone in ErbB2 over
expressing breast cancer cells. Intl. J. Cancer 157-164.
98.
K Masker, A. Golden, C. J. Gaffney, V. Mazack, W. F. Schwindinger, W. Zhang, L.-H. Wang, D.J.
Carey and M. Sudol (2007). Transcriptional profile of Rous Sarcoma Virus transformed chicken
embryo fibroblasts reveals new signaling targets of viral src. Virology 364:10-20.
11
99.
Cheng G Z, Zhang W, Wang L.-H. (2008) Regulation of cancer cell survival, migration
and invasion by Twist: AKT2 comes to interplay. Cancer Research 68:957-960.
100.
Uttamsingh, S, Bao, X., Nguyen, K. T., Bhanot M., Chan J. L.-K., Liu F, Chu T. and
Wang, L-H. (2008) Synergistic effect between EGF and TGF-1 in inducing oncogenic
properties of intestinal epithelial cells. Oncogene 27:2626-2634.
101.
Cheng G Z, Zhang W, Sun M, Wang, Q, Coppola D, Costanzo C, Xu L M, Chan J, Cheng
J Q, Wang L-H. (2008) Twist is Induced by Activation of STAT3 and Mediates STAT3
Oncogenic Function. J. Biol. Chem. 283:14665-73.
102.
Cheng G. Z., Park S., Shu S., He L., Kong W., Zhang W., Yuan Z., Wang L.-H., Cheng
J. Q. (2008) Advances of AKT pathway in human oncogenesis and as a target for anticancer drug discovery. Current Cancer Drug Targets 8:2-6.
103.
Wang, L.-H. (2008) Overview of modular domains and adaptor proteins, pp1-32 in
“Adaptor proteins and cancer” ISBN 978-81-7895-344-1, Ed. M. Georgescu, Transworld
Research Network, Trivandrum-695 023, Kerala, India.
104.
Zhang, W., Cheng, G.Z., Hermanto, U., Zong, C.S., Chan, J., Cheng, J. and Wang, L.-H.
(2008) RACK1 and CIS mediat the degradation of BinEL in Cancer cells J. Biol. Chem.
283:16416-26.
105.
Schlosshauer, P.W., Li, W., Lin, Kai-Ti., Chan, J. L-K. and Wang, L.-H. (2009)
Rapamycin by itself and additively in combination with carboplatin inhibits the growth of
ovarian cancer cells. Gynecologic Oncology 114:516-522.
106.
Shih Sheng Jiang1, Wen-Tsen Fang1, Ya-Shi Ho1,6, Shiu-Feng Huang2, Betty Lin-Ju
Yen3, Junn-Liang Chang4, Shi-Miao Li1, Hui-Ping Liu5, Ying-Lan Liu1, Chi-Ting
Huang1, Yu-Wei Li3, Te-Hsuan Jan2, Su-Jing Yang6, Chao A. Hsiung7, Cheng-Wen
Wu1, Lu-Hai Wang2, and I-Shou Chang1* Upregulation of SOX9 in lung adenocarcinoma
and its involvement in the regulation of cell growth and tumorigenicity (2010) Clinical
Cancer Research, 16: 4363-4373.
107.
Yu-Chen Tsai, Sidney Pestka, Lu-Hai Wang, Leroy F. Liu. Transformation-Induced
Interferon: Modulation of Tumor Phenotypes through ISG15 (submitting)
108.
K.T. Lin, Gong, J, Sachdev, P. Cheng G, Mansour, M. and Wang, L.-H. Vav3-mediated
migration and invasion in prostate cancer cells depends on activation of Rac1/Akt
signaling (in preparation)
109.
W.L. Chen, Bhanot M., Cheng G. Z., Zhang W., and Wang L.-H. Molecular
characterizations and biological implications of a novel insulin-interacting protein. (in
preparation)
110.
Gong, J and Wang, L.-H. Activated Vav3 evades contact inhibition via signaling of
RhoA/ROCK/mDia and cyclin D/p27 cip pathways (in preparation)
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