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HangYing Dong
8851 N Oracle Rd. Apt. 135
Tucson, AZ 85737
(520) 877-1071(Home)
(520) 544-5892(Work)
(650) 814-0631(Mobile)
hangyingd@yahoo.com
http://www.cs.wisc.edu/~hangying/hangying.html
Permanent Resident
SUMMARY OF QUALIFICATIONS
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Solid background in both biology (Cell biology and Toxicology) and
computer sciences. Extensive experiences in scientific research and
software development (C/C++, Java, Python, Oracle PL/SQL, VB/VBA, PERL,
Shell scripting…).
Good understanding of drug discovery process. Very familiar with Oracle
databases and many novel bio/cheminformatics tools.
Good interpersonal and communication skills. Ability to work with a
diverse group of customers in a cross-functional team environment.
Highly motivated, resourceful, and strong problem solving capability.
WORKING EXPERIENCE AND PROFESSIONAL ACTIVITIES
12/2002 – Present
Informatics/IS

ActivityBase administrator, responsible for
Application Specialist protocols/templates design and implementation for
Aventis
lead discovery data management in both HTS and LTS
Pharmaceuticals
databases. 
Tucson, AZ

Close collaboration with chemists and lead discovery
biologists to identify key requirements for automated
data capture, quality control, result analysis and
sharing data globally across projects.
 Daily problem solving, user training and
documentations.
08/2000 – 07/2002
Informatics Research
Scientist
Computational Drug
Discovery
Exelixis, Inc.
South San Francisco,
CA

Large
cheminformatics database (IDBS ActivityBase)
administrator, responsible for database setup,
maintenance, trouble-shooting and customization.
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Assay protocol design and implementation for efficient
scientific data management, including automatic data
import into the database, quality control, appropriate
data analysis and result interpretation. Have designed
UHTS, HTS and other standard protocols for High
Throughput Screening, Dose-response IC50/EC50
measurements(including curve fitting), In vitro ADMET,
In vivo PK/ADME and Efficacy assays.
 Close collaboration with chemists and new leads
biologists for software customization and new tool
development by adding Excel Macros and the other web
based applications.
 Structure-Activity report generation, data mining and
visualization using SARgen, Spotfire and other inhouse software applications.
 Web based application development for data analysis
and retrieval with Python, SQL, Java, JavaScript,
allowing users to get info from databases on the web.
 Internal informatics user training and daily problem
solving for scientific or technical issues. Identify,
evaluate, deploy and test new software, databases and
other informatics tools for new needs.
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08/1999 – 08/2000
Software Engineer
IBM AIX RS/6000
Server Group, IBM
Austin, TX
01/1999 – 07/1999
Software Engineer
Madison, WI
DNASTAR Inc.
06/1998 – 08/1998
Software Engineer
Sanchez Computer
Associates, Inc.
Malvern, PA

Oracle
database administrator and server application
developer using Oracle PL/SQL Web Toolkit. Web based
reporting system development for users to get info
from databases on the web.
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AIX Program product build and packaging.
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Sequence
analysis software development (LaserGene,
SeqMan II) for genetic research on Windows and Apple
Macintosh platforms using C programming language.

Established
test suites using MUMPS programming
language and Shell scripts for testing various
features of GT.M database system (a Greystone
Technology Corporation's implementation of standard
MUMPS for UNIX and VAX/VMS systems) in UNIX and
VMS platforms.
11/1994 – 01/1999
Assistant Researcher

Research projects: "Regulation of tumor cell kinetics
Lab Manager
using in vitro and in vivo models". Study on a series
Clinical Science Ctr.
of kinetics parameters, such as Tumor Potential
University of
Doubling Time (Tpot), Length of S phase (Ts),
Wisconsin at Madison
Ki-67, AgNOR, for providing useful estimators of
intra-treatment tumor proliferation capacity. The
parameters were determined using in situ labeling of
tumor DNA with halogenated pyrimidines followed by
flow cytometric analysis, silver or immunostaining
methods.
 Responsible for experiment design, supervising, assay
data analysis using different software and scientific
paper publication.
01/1990 – 05/1994
Research Assistant
INSERM U.139
Environmental
Toxicology
Créteil, France
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Ph.D
thesis study on mechanisms of cytotoxicity and
DNA damage induced by asbestos and other chemicals
using in vivo and in vitro models.
EDUCATION
May 1999
Master’s Degree in Computer Sciences, GPA 3.9
University of Wisconsin – Madison
May 1994
Ph.D. in Cell Biology and Molecular Toxicology
University of Paris XII, Créteil, France
May 1989
Master’s Degree in Toxicology and Pharmacology
Nanjing Medical College, P.R China
December 1982
Bachelor’s Degree in Medicine
Nanjing Medical College, P.R China
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COMPUTER TECHNICAL SKILLS
Programming
Languages:
C/C++, Java, Python, VB/VBA, MUMPS, PL/SQL, QBE, UNIX Shell
(C Shell and KornShell), PERL, HTML, XML, JavaScript, Excel
programming
Platforms:
SUN/AIX/HP UNIX Workstations, X Window, VAX/VMS,
LINUX, Windows NT/2000 and Macintosh Programming
Bioinformatics
Tools:
BLAST, sequence alignment, contig assembly, primer design,
LIMS, Phred, Phrap, DANStar SegMan II, LaserGene
Cheminformatics
Tools:
MDL ISIS database, IDBS ActivityBase, SARgen, Scitegic
Pipeline Pilot, Spotfire, XLFit
OTHER PROGRAMMING PROJECTS
Database
Projects:

Operating System
Projects:
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Networking
Projects:
Implemented Buffer Manager (manages buffer pool), Heap
File Manager, B+ Trees, Sort Merge Join on a DBMS in C++.
 Designed and implemented Disk Space Manager (allocation
and deallocation of pages within a database), Buffer
Manager, Heap File Manager on a DBMS in Java.
Developed protocols for interprocess communication and
synchronization using pipes, semaphores in C++.
 Simulated and evaluated different page replacement
algorithms using real memory trace data from UNIX systems
in C++.
 Measured kernel performance using extended lmbenchmark
in C.
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Developed a prefetching protocol for Web access streams by
aged probability graphs in C.
 Designed a parallel workload generator, an analyzer and a
cpu scheduler for a parallel computer with a graphic user
interface in Java.
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Developed
a Client-Server protocol with UDP as its
transport layer protocol using BSD Socket and Posix thread
in C.
 Built a reliable transport layer protocol over a
virtual-circuit(VC) based network layer protocol in C++.
File Transfer Application (FTP) was linked to protocols
Which supported reliable file transfers between nodes
across an unreliable network.
PUBLICATIONS
Dong HY, Saint-Etienne L, Renier A, Billon-Galland MA, Brochard P and Jaurand
MC. Air samples from a building with asbestos containing material: Asbestos
content and in vitro toxicity on rat pleural mesothelial cells. Fundamental
and Applied Toxicology, 22:178-185, 1994.
Dong HY, Buard A, Renier A, Saint-Etienne L and Jaurand MC. Role of oxygen
derivatives in the cytotoxicity and DNA damage produced by asbestos on rat
pleural mesothelial cells in vitro. Carcinogenesis, 15:1251-1255, 1994.
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Dong HY, Yegles M, Renier A, Bignon J and Jaurand MC. Cytotoxic and genotoxic
effects of vitreous microbeads with different iron content on rat pleural
mesothelial cells in culture. ILSI (International Life Sciences Institute)
Series, Eds by Mohr,U.; Dungworth,D.L.; Oberdorester,G. In: Toxic and
carcinogenic effects of solid particles in the respiratory tract. ILSI Press,
Washington D.C., p.419-422, 1994.
Dong HY, Buard A, Levy F, Renier A, Laval F and Jaurand MC. Synthesis of
poly(ADP-ribose) in asbestos-treated rat pleural mesothelial cells in culture.
Mutation Research, 331:197-204, 1995.
Dong HY, Bertler C, Schneider E and Ritter MA. Assessment of cell
proliferation by AgNOR scores and Ki-67 labeling indices and a comparison with
potential doubling times. Cytometry, 28:280-288, 1997.