FIRST ANNUAL HEALTH ECONOMICS & PERSONALISED MEDICINE SYMPOSIUM: CREATING A PERSONALISED MEDICINE PARADIGM FOR ONCOLOGY LUXEMBOURG, 18-19 JUNE 2012 INTRODUCTION Dear Colleagues, It is my great pleasure to welcome you to the First Annual Health Economics and Personalised Medicine Symposium: Creating a Personalised Medicine Paradigm for Oncology, jointly presented by the Centre de Recherche Public de la Sante (CRP-Santé), the Directorate General for Health and Consumers (DG Sanco) of the European Commission, and the Fred Hutchinson Cancer Research Center, Seattle, USA. We are delighted to host international experts from a range of stakeholder groups including academia, healthcare and industry, to explore key issues at the interface of health economics, personalised medicine and oncology. In Luxembourg, we recognize that integrating health economics into the research enterprise is essential to achieving our vision of translating scientific knowledge into clinical applications impacting healthcare. Our intent today is to establish a framework and public dialogue for health economics in the context of emerging trends toward personalized medicine in oncology, recognizing that success will require strong collaboration between experts in a broad range of disciplines. We hope the program will identify priority areas for research and health policy development related to personalized medicine in oncology, and inspire new collaborations to address pressing needs at the intersection of these disciplines. I thank you for your participation, and look forward to productive discussion and interactions throughout the symposium. Sincerely, Jean-Claude Schmit, CEO CRP-Santé OBJECTIVE OF THE CONFERENCE Personalised medicine offers the promise of improving cancer care by allowing clinicians to tailor treatments based on patients' molecular and epidemiologic profiles. Because of the unique nature of personalised medicine and how it is applied in health care, finding efficient and effective ways to evaluate and adopt these technologies poses particular challenges for health systems, clinicians, and patients. This goal of this highly interactive symposium is to highlight and discuss issues decision makers at all levels must consider to promote the most effective development and use of personalised medicine technologies for cancer. Several clinical case studies of personalised oncology care will be examined to facilitate the discussion. The overall objective of the symposium is to identify research priorities, policies and programs to facilitate the development of evidence that can support the adoption of high value personalized medicine technologies for oncology in Europe. HEALTH ECONOMICS RESEARCH CENTRE BACKGROUND AND RATIONALE As part of an overall strategy to enhance the impact of biomedical research on the effectiveness and efficiency of health care delivery, both in Luxembourg and globally, CRP-Santé is establishing a Health Economics Research Centre (HERC). The center is expected to develop unique competence in applied research related to the economic aspects of personalized medicine and molecular diagnostics. A core goal of the HERC is to ensure that biomedical innovations are translated into cost-effective care and improved health for the Luxembourg population. A secondary and long-term goal of the center will be to serve as a national knowledge center for provision or analysis of public health information, particularly as it relates to personalized medicine. MISSION STATEMENT The mission of the Health Economics Research Centre is to improve the health of the Luxembourg population by conducting high-quality health economics research at the interface between molecular diagnostics, personalized medicine and public health. The center will facilitate the translation of research results into improved health care by identifying cost-effective health care strategies and technologies to prevent and treat illness, and engaging multidisciplinary collaborators within Luxembourg’s healthcare delivery system to devise efficient and effective implementation strategies. Core research activities will include innovation and excellence in developing theoretical and applied methods for health technology assessment, performing cost and cost-effectiveness analyses, health care decision modeling, and health care policy research as they apply to emerging diagnostics.