IMIN 371, Introduction to Immunology
Fall Term 2012
Humanities Centre (HC) L1, M W F 12:00 - 12:50
Lecturers:
Dr. Robert Ingham (Lecturer)
Email: ringham@ualberta.ca
Office: 6142-H Katz Bldg.
Hours: Appointment (email).
Amanda Scott (Guest Lecturer)
Email: anscott@ualberta.ca
Office: 6-70 Heritage Med Res Ctre
Hours: Appointment (email)
Dr. Brad Magor (Coordinator)
Email: bmagor@ualberta.ca
Office: CW-323, BioSci. Bldg.
Hours: Drop-in or Appointment (email)
Dr. Luis Hidalgo (Guest Lecturer)
Email: luis.hidalgo@ualberta.ca
Office: 2-60 Heritage Med Res Ctre.
Hours: Appointment (email)
Dr. Denise Hemmings (Lecturer)
Email:denise.hemmings@ualberta.ca
Office: 227 Heritage Med Res Ctre
Hours: Appointment (email)
Course Description
*3 (fi 6) (first term, 3-0-0). Immunology.
This is an intermediate course in mammalian immunology (the introduction &
prerequisite is IMIN 200). Topics include the clonal selection theory, antibody structure
and specificity, genetic basis of immune diversity, antibody-antigen reactions, cell
interactions in immune responses, the molecular basis of non-self recognition, MHC
molecules and transplantation, tolerance, effector mechanism of immunity,
hypersensitivity and immunodeficiency. May not be taken for credit if credit already
obtained in INT D 371. (Offered jointly by the Department of Biological Sciences and
the Department of Medical Microbiology and Immunology.) [Biological Sciences]
Prerequisites: BIOCH 200 or 205, BIOL 207, and IMIN 200.
Course Goals
When you have completed the work in this course you will be able to:
1. Understand specific aspects of the immune system to be able to read with
confidence newspaper and popular magazine reports dealing with immunologic
topics and to participate with confidence in other university or college courses that
peripherally deal with immunologic topics (e.g., in areas of nursing, medicine,
agriculture, pharmacy, law, business, infectious diseases, and engineering).
2. Enroll in more advanced undergraduate and graduate courses that deal specifically
with immunologic topics in the areas of immunology and infections.
3. Write concise answers to questions relating to complex biological phenomena.
Textbook
The recommended text for this course is “Kuby Immunology”, by Thomas Kindt,
Richard Goldsby and Barbara Osborne, sixth edition (WH Freeman and Co). The text
can be purchased in the book store and a copy has been placed on reserve in each of the
Cameron and Scott libraries.
How to Succeed in IMIN 371
Attend all lectures as you are responsible for the material presented in class lectures. The
text pages listed in the Lecture Outline (below) are for your benefit and increased
understanding. In addition, we will refer to many Figures in the text during lectures.
You are responsible for knowing the material in those Figures as pertains to the class
material. All Figures are posted on the class website (see below).
IMIN 371 Website - Lecture Information
Lectures (Powerpoint), supplementary material (handouts) and the syllabus will be
available on the IMIN 371 page on the Dept of Biological Sciences web site (this is not
WebCT):
http://www.biology.ualberta.ca/courses/imin371/
User & Password will be provided in first lecture – ask a classmate/TA/Instructor if
you’ve misplaced them.
Teaching Assistants, Review Questions and Help Sessions.
TA
Samuel Cheung
Kinola Williams
Daniel Pang
Location
Email
HMRC 6-70
HMRC 6-70
Katz 6-096
scheung1@ualberta.ca
kinola@ualberta.ca
dp1@ualberta.ca
Review Questions – review questions (developed by the TAs) based on the lecture
material will be posted periodically. The answers to the questions will be posted the
following week. Students are encouraged to keep up with the questions as they are
intended to reinforce major concepts covered in class, to test yourself on comprehension
of the material and to practice answering questions of a similar format as the
examinations.
The TAs will convene help sessions during the week before a midterm or final exam.
The times and locations of the help sessions will be announced in class and posted on the
website.
The TAs and teaching staff will answer straightforward questions by email at any time.
Students requiring more in depth explanations or with a long list of questions are
encouraged to make an appointment with a TA or instructor.
Grading of Course
Your total grade in the course will be determined as follows: 25% for first midterm
exam, 25% for the second midterm and 50% for the final exam. The total numerical
score will be converted to a grade on the University’s A-F grading system. It is most
likely that the grades will follow a normal distribution with an average somewhere
between B- and B+. We use a combination of peer comparison and University of Alberta
suggested grade distribution for the final marks.
The following grades will be assigned (at a minimum) if your overall and final exam
grades are:
> 50 % - Pass (D)
> 60 % - C> 80 % - A> 70 % - B> 90 % - A+
The final exam is cumulative and will be weighted ~ 60% on material covered after the
second midterm and ~ 40% on material covered prior to the second midterm.
Remember to Bring ID to the final exam
Deferred Exams:
What to do if you miss a midterm exam: A student with a documented absence from
either University Health Services or Records Division, Examinations and Timetabling
(for sworn affidavits) will be granted an exemption from one midterm exam once the
documentation is approved by an instructor. The percentage weight of the missed exam
will be added to the percentage weight allotted to the Final Exam; there will be no
deferred midterm examinations given. The student must obtain the necessary
documents and contact an instructor within TWO working days of the missed exam.
What to do if you miss the final exam: All deferred final exams will be oral
examinations held early in January. The student must obtain documentation from
University Health Services or Records Division, Examinations and Timetabling (sworn
affidavit) and this documentation must be submitted to the student’s own faculty office
within TWO working days of the missed exam. The deferred application will be
approved or denied by the student’s faculty. If the application is approved, the student
will be automatically billed a processing fee. Once the student has completed the above
process and has received approval to write the deferred exam, he/she can contact the
instructor or Department office to receive further instructions about when the oral
examination will be scheduled.
Code of Student Behaviour
The University of Alberta is committed to the highest standards of academic integrity and
honesty. Students are expected to be familiar with these standards regarding academic
honesty and to uphold the policies of the University in this respect. Students are
particularly urged to familiarize themselves with the provisions of the Code of Student
Behavior (online at www.ualberta.ca/secretariat/appeals.htm) and avoid any behavior
which could potentially result in suspicions of cheating, plagiarism, misrepresentation of
facts and/or participation in an offence. Academic dishonesty is a serious offence and can
result in suspension or expulsion from the University.
STUDENTS WITH DISABILITIES: Students who require accommodation in this
course due to a disability are advised to discuss their needs with Specialized Support &
Disability Services (2-800 Students’ Union Building).
ACADEMIC SUPPORT CENTRE: Students who require additional help in
developing strategies for better time management, study skills or examination skills
should contact the Academic Support Centre (2-300 Students’ Union Building).
Cell Phones – Turn off cell phones during lectures. Cell phones & other electronic
devises are not permitted at exams & their presence constitutes academic misconduct.
Lectures, Instructors & optional associated readings
Date
Topic
Instructor
Kuby 6th Ed
Sept 5
Course Overview & Review
Dr. Magor
Chapter 2
Sept 7
Cells & Tissues
Dr. Magor
Chapter 2
Sept 10
Innate Immunity
Dr. Magor
Chapter 3
Sept 12
“”
Dr. Magor
Chapter 3
Sept 14
“”
Dr. Magor
Lecture notes
Sept 17
“”
Dr. Magor
Chapter 7
Sept 19
“”
Dr. Magor
Chapter 7
Sept 21
Antigens and Antibodies
Dr. Magor
Chapter 4
Sept 24
“”
Dr. Magor
Chapter 4
Sept 26
“”
Dr. Magor
Chapter 5
Sept 28
“”
Dr. Magor
Chapter 5
Oct 1
Midterm 1
Oct 3
B cell development I – early events
Dr. Ingham
Chapter 11
Oct 5
B cell development II – the pre-BCR
Dr. Ingham
“”
Oct 8
No Class - Thanksgiving Holiday
Oct 10
B cell development III – allelic exclusion
Dr. Ingham
“”
Oct 12
B cell development IV – negative selection Dr. Ingham
“”
Oct 15
B cell activation I – introduction
Dr. Ingham
“”
Oct 17
B cell activation II – BCR signalling
Dr. Ingham
“”
(25%, Sept 5 – 28)
Date
Topic
Instructor
Kuby 6th Ed
Oct 19
B cell activation III – other signals
Dr. Ingham
“”
Oct 22
B cell activation IV – effector cells
Dr. Ingham
“”
Oct 24
MHC and Ag presentation I – introduction Dr. Ingham
Chapter 8
Oct 26
MHC and Ag presentation II – presentation Dr. Ingham
‘’
Oct 29
Midterm 2
Oct 31
T cell Development
Dr. Hemmings
Chap 9
Nov 2
T cell Development
Dr. Hemmings
Chap 9
Nov 5
T cell Activation
Dr. Hemmings
Chap 10
Nov 7
T cell Activation
Dr. Hemmings
Chap 10
- (25% - Oct 3-26)
*****last day to drop course is Nov 7th
Nov 9
Th subsets and infection
Dr. Hemmings
Suppl notes
Nov 12
No Class – Remembrance Day Holiday
Nov 14
CTL and memory CD8+ T cells
Dr. Hemmings
Chap 14
Nov 16
NK responses
Dr. Hemmings
Chap 14
Nov 19
Mucosal Immunity
Dr. Hemmings
Suppl Notes
Nov 21
Immune Response to Infection
Dr. Hemmings
Chap 18
Nov 23
Autoimmunity and Tolerance
Dr. Hemmings
Chap 16
Nov 26
Autoimmunity and Tolerance
Dr. Hemmings
Chap 16
Nov 28
The Immunology of Pregnancy
Dr. Hemmings
Lecture notes
Nov 30
Hypersensitivity and Allergy
Amanda Scott
Chap 15
Dec 3
Transplantation
Dr. Hildago
Lecture notes
Dec 5
Immunodeficiencies
Dr. Ingham
Chap 20