Lesson Plan PTT 304/3
Sem I 2013/14
UNIVERSITI MALAYSIA PERLIS (UniMAP)
Pusat Pengajian Kejuruteraan Bioproses
COURSE OUTLINE
(1) Kod kursus/ Course code: PTT 304
(2) Tajuk kursus/ Course title: Teknologi Fermentasi / Fermentation Technology
(3) Nilai unit/ Number of unit:
3
(4) Jenis kursus/ Course type:
Teras / Core
(5) Prasyarat/ Prerequisite: Nil
(6) Sinopsis kursus / Course synopsis:
This course covers both theoretical and practical aspects of fermentation and bioprocess
technology. It also describes several fermentation processes involved in the production of
industrial chemical metabolites such as alcohol, organic acids, proteins, enzymes and
antibodies.
(7) Hasil Pembelajaran / Learning Outcomes:
At the end of the course, students are expected to acquire these abilities:
1. Ability to differentiate various fermentation methods including control parameters
2. Ability to calculate mass balances stoichiometry and microbial growth kinetics in batch,
fed-batch and continuous fermentations.
3. Ability to calculate sterilization times, aeration requirement and capacities of batch, fedbatch and continuous fermentation
4. Ability to illustrate the principles of up and down-scaling of fermentation processes and
primary recovery methods
Lesson Plan PTT 304/3
Sem I 2013/14
(8) Senarai eksperimen / List of experiments:
Lab 1
Lab 2
Lab 3
Lab 4
Lab 5
Lab 6
Lab 7
Lab 8
Lab 9
Lab 10
Lab 11
Lab 12
Lab 13
Lab 14
: Introduction to fermentation laboratory safety
: Media development and vessel sterilization
: Growth evaluation of fungal in liquid-state fermentation
: Growth evaluation of fungal in solid-state fermentation
: Effect of mixing on substrate consumption in fermentor
: Effect of agitation on kLa in a fermentor
: Bioethanol production in batch fermentation
: Bioethanol production in continuous fermentation
: Bioproduct recovery by crystallization via chemical approach
: Bioproduct recovery by crystallization via physical approach
: Bioproduct recovery by liquid-liquid extraction
: Bioproduct recovery by aqueous two phase extraction
: Open-ended experiment: Production of industrial bioproducts through fermentation
: Open-ended experiment: Bioproduct recovery
(9) Pendekatan pembelajaran / Learning approach:
Lectures
Laboratory
: 40% (28 hours)
: 60% (42 hours)
(10) Sumbangan penilaian / Evaluation contribution:
1. Peperiksaan akhir semester/ Final examination:
40%
2. Peperiksaan pertengahan semester /Midterm exams:
20%
3. Kerja kursus/Course work:
40%
Perincian sumbangan kerja kursus/ Details of course work contribution:
i.
Lab Reports and Test (30%)
ii.
Assignments & Quizzes (10%)
(Kuiz boleh diberi tanpa notis/Quiz can be given without prior notice)
(11) Pensyarah dan Pegawai Latihan Vokasional / Lecturers and Teaching Engineers:
Encik Mohamad Fahrurrazi Tompang (C)
Puan Noor Shazliana Aizee Abidin
PM Dr. Mohamed Zulkali Mohamed Daud
Lesson Plan PTT 304/3
Sem I 2013/14
(12) Senarai buku teks dan rujukan / List of text books and references :
Buku Teks/ Text book(s):
i) Shuler, M. L. and Kargi, F. (2001). Bioprocess Engineering: Basic Concepts.” 2nd ed.
Prentice Hall PTR, Upper Saddle River, NJ.
ii) Doran, P. M. (2012). Bioprocess Engineering Principles. Academic Press, London.
Buku Rujukan/ Reference books:
i) Najafpour, G.A. (2007). Biochemical Engineering and Biotechnology. Elsevier B.V.,
Amsterdam.
ii) Katoh, S. and Yoshida, F. (2009). Biochemical Engineering: A Textbook for Engineers,
Chemists and Biologists. Wiley-VCH Verlag GmbH & Co. KGaA.
iii) Mitchell, D. A., Krieger, N. and Berovic, M. (2006). Solid-state Fermentation Bioreactors:
Fundamentals of Design and Operation. Springer Berlin Heidelberg.
iv) Asenjo, J. A. and Merchuk, J. A. (1995). Bioreactor System Design. Marcel Dekker Inc,
New York.
Lesson Plan PTT 304/3
Sem I 2013/14
RANCANGAN MENGAJAR/LESSON PLAN
Minggu/Week
Kandungan Kursus / Course Contents
(Panduan/Guidelines)
Tugasan
Bacaan/Reading
Assignment
Pensyarah/Lecturer
Handouts
Pn. Noor
Shazliana
Handouts
Pn. Noor
Shazliana
Chapter 9
(Shuler & Kargi)
Pn. Noor
Shazliana
Chapter 13
(Doran)
En. Mohamad
Fahrurrazi
Tompang
INTRODUCTION TO INDUSTRIAL FERMENTATION
TECHNOLOGY
Week 1
Historical background of fermentation (industrial
and food), latest development and future
trends
BIOLOGICAL SYSTEMS AND MEDIA DESIGN
Week 2 – 3
Differences general growth characteristics of
microorganisms (bacterial, yeast and fungi),
influence of microbial characteristic on
bioreactor selection, isolation and screening,
preservation and improvement, media formulation
based on macro- and microelements in
microbial.
PRODUCTION OF INDUSTRIAL PRODUCTS
THROUGH FERMENTATIONS
Week 4 - 5
Differences on type of fermentation liquid-state
and
solid
state
fermentation
process,
production of industrial products such as
alcohol, organic acids, vitamins, amino acids,
single cell protein, antibiotics, enzymes through
fermentations.
STERILIZATION AND EQUIPMENT
Week 6 – 7
Kinetics of sterilization, methods of measuring
process variation control system, computer
application in fermentation technology.
Midterm Exam 1 (1 hour)
Week 8
Cuti Pertengahan Semester / Mid-semester Break
DESIGN, INSTRUMENTATION AND CONTROL OF
FERMENTORS
Week 9 – 11
Strategies for bioreactor design, schematic
diagrams of stirred and air-driven bioreactors,
advantages between stirred and air-driven
bioreactors. Differences the types of impellers
Chapter 7 & 9
(Doran) &
Handouts
En. Mohamad
Fahrurrazi
Tompang
Lesson Plan PTT 304/3
Sem I 2013/14
based on fluid viscosity; flow patterns in
agitated tanks, time and power requirement of
mixing, heat transfer and mass transfer of
oxygen and gas hold up, types of spargers; flow
pattern in stirred aerated tanks, bioreactor
design based on calculations of Reynolds
number, power requirement and oxygen
transfer rate, system to control temperature for
small bioreactors, working principles of dissolved
oxygen and pH electrodes.
CULTIVATION
KINETICS
Week 12 – 13
OPERATIONS
AND
GROWTH
Differences between batch and continuous
system based on productivity, modifications for
batch and continuous bioreactor, scale-up and
scale-down
development
process
for
fermentors and consequence of changing the
scale of operation,
Chapter 9 & 10
(Shuler & Kargi)
& Handouts
PM Dr. Mohamed
Zulkali
Handouts
PM Dr. Mohamed
Zulkali
PRODUCT RECOVERY AND EFFLUENT TREATMENT
Week 14 – 15
Extraction and separation, product enrichment,
thermal process, membrane filtration and
dialysis,
freeze
concentration,
chromatographic
methods,
purification,
crystallization and drying, effluent treatment
Midterm Exam 2 (1 hour)
Week 16
Week 17 - 18
Minggu Ulangkaji / Revision Weeks
Peperiksaan Akhir Semester/ Final Examination
Lesson Plan PTT 304/3
Sem I 2013/14
RANCANGAN MAKMAL / LABORATORY PLAN
Group
Week
1
Week
2
Week
3
Week
4
Week
5
Week
6
Week
7
Week
8
Week
9
Week
10
Week
11
Week
12
Week
13
Week
14
Week
15
Week
16
A1
A2
A3
B1
B2
B3
Lab 1
Lab 2
Lab 3
Lab 4
Lab 5
Cuti Pertengahan Semester / Mid Semester Break
Lab 6
Lab 7
Lab 8
Lab 9
Lab 10
Lab 11
Lab 12
Lab 13
Lab 14 / Lab Test
Revision Week
Nota Penting: Kehadiran pelajar ke kuliah/tutorial/makmal adalah WAJIB. Jika tidak
hadir tanpa sebab, pelajar boleh dihalang daripada menduduki peperiksaan akhir.
Lesson Plan PTT 304/3
Sem I 2013/14
KUMPULAN MAKMAL/ LAB GROUPS
GROUP A
GROUP B
Group: A1
Ahmad Khairul Anuar Bin Ramli
Aimi Shazwani Binti Shariffuddin
Aminah Binti Ideris
Asmalaili Binti Salehudin
Tan Chai Yun
Group: B1
Azzahra Binti Aripin
Enis Natasha Noor Binti Arbaain
Faten Syamimi Binti Kamyis
Fatin Izzati Binti Mohmed Azmi
Group: A2
Kuek Sze Teng
Lau Sin Mun
Meor Azeem Bin Meor Azli
Noor Safira Aina Binti Arshad
Wan Asma Salsabila Binti Wan Mohd Nor
Group: B2
Nor Amirra Binti Abu Nayan
Norainon Maulad Nashir
Nur Azreen Binti Ariffin
Nurul Sakinah Binti Mohd Nor
Group: A3
Nur Farahin Binti Rostam
Nur Syazana Binti Jalani
Nursyafiqah Athirah Binti Mohamad
Zabidi
Zafryl Zaheidy Bin Mustofa
Group: B3
Siti Farahain Binti Abd Rahman
Siti Mariam Binti Mazalan
Siti Noraffiyah Binti Monshi
Siti Nurulnasyra Athira Binti Azman