ADDENDUM
HALF LIFE VERIFICATION INSTRUCTIONS
MOLY ASSAY INSTRUCTIONS
ADJUSTING BACKGROUND TIME INSTRUCTIONS
FOR ATOMLAB 500 DOSE CALIBRATOR, ATOMLAB 500PLUS AND
ATOMLAB WIPE TEST COUNTER
SOFTWARE VERSION 1.33
086-330
086-331
086-332
BIODEX
Biodex Medical Systems, Inc.
20 Ramsey Road, Shirley, New York, 11967-4704, Tel: 800-224-6339 (Int’l 631-924-9000), Fax: 631-924-9241, Email: info@biodex.com, www.biodex.com
FN: 14-027 2/14
Table of Contents
INTRODUCTION ............................................................................................................................ 3
CHAPTER 1 - HALF LIFE VERIFICATION APP
FOR ATOMLAB DOSE CALIBRATOR ................................................................................... 4
Intended Use ................................................................................................... 4
Indications For Use .......................................................................................... 4
Half Life Verification ........................................................................................ 4
Performing a Half Life Verification .................................................................... 5
Formula for Calculating Half Life ...................................................................... 12
Formula for Half Life Variance .......................................................................... 12
CHAPTER 2 - DOSE CALIBRATOR SETTABLE BACKGROUND
COUNTING TIME ........................................................................................................................ 13
Information ...................................................................................................... 13
Procedure to Adjust the Background Counting Time ........................................ 13
CHAPTER 3 - MOLY ASSAY FOR THE ATOMLAB DOSE CALIBRATOR ..................... 15
Description ...................................................................................................... 15
Procedure Addition .......................................................................................... 16
CHAPTER 4 - DOSE CALIBRATOR ADDITIONAL ISOTOPE ........................................... 19
Additional isotope, Ra-223, added to Dose Calibrator Isotope List ...................
CHAPTER 5 - ATOMLAB WIPE TEST COUNTER ADDITIONAL ISOTOPES ............... 20
Information ...................................................................................................... 20
Isotope Settings ............................................................................................... 21
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Introduction
This new software version addendum for the Atomlab 500 Dose Calibrator is an update to the
production version 1.31 software. It works with the WinCE Operating System in the Atomlab
500 Dose Calibrator. The new version is software version 1.33 2/14/2014.
This addendum adds three things to the present Atomlab 500 Dose Calibrator:
1. The new application is a Half Life Verification APP used in Nuclear Pharmacies.
2. It allows the user to set the system’s background counting time to be either 30, 60 or
100 seconds. The current version is a 100 second count. If you are measuring sources
less than 20 µCi of Tc-99m increasing the background to 100 seconds will improve your
accuracy.
3. The Moly Assay Program has had a slight modification in that the background counting
time can be adjusted for 30, 60 or 100 seconds. Changing the Moly background
counting time in the Moly Assay Program will change the background time for Dose
Calibrator Zero Background Functions.
4. Ra-223 is added to the Isotope List in the Atomlab 500 Dose Calibrator Program.
This addendum adds two isotopes, Lu-­‐177 and Ra-­‐223, to the Wipe Counter Isotope List including the Region of Interest and the Isotope Efficiencies. The detailed sections of this addendum describe how to use the changes for each of these
items.
NOTE: This addendum is not a complete manual for the Atomlab 500.
ATOMLAB DOSE CALIBRATOR 500, 500PLUS AND WIPE TEST COUNTER ADDENDUM
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1. Half Life Verification APP for
Atomlab 500 Dose Calibrator
Intended Use
The Half Life Verification APP is intended to check a radioactive isotope to determine the actual
Half Life of the isotope sample.
Indications For Use
In a Nuclear Pharmacy it is common practice to test certain isotopes for contamination from
other isotopes before use. This test is typically performed for PET isotopes such as F-18. The
Half Life is calculated from either two or three timed activity readings in the dose calibrator.
The system then calculates the actual Half Life of the sample and shows the variance
percentage to the system listed isotope Half Life. It is the user’s responsibility to determine if
this variance is acceptable.
Half Life Verification
(See Figures 1.1 and 1.2.)
The Half Life Verification APP allows the user to select the isotope, set test parameters; select
either 2 or 3 readings and set the elapsed time between the readings. The time can be set
between 1 minute and 60 minutes. You can also enter the lot number. When the test is
complete, print your results. The results show the preset Half Life for the isotope selected and
the calculated Half Life from the two or three activity readings.
NOTE: The dose calibrator does not store the Half Life calculation. You can print the results.
NOTE: It is up to the user to decide if this variance is acceptable or if there are too many
contaminants in the isotope to use it.
Figure 1.1. Nuclear Pharmacy screen.
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Figure 1.2. Half Life screen.
To Perform a Half Life Verification:
1. At the Home screen, select <Nuclear Pharmacy>. The Nuclear Pharmacy screen is now
displayed.
2. Select <Half Life Verification>. The Half Life Verification APP is now displayed.
3. Make sure there are no sources near the dose calibrator chamber.
4. Press <Select Isotope> to change the isotope from the isotope displayed at the top of the
screen. You can select any isotope from the isotope list that is in the dose calibrator.
5. To select the isotope use the scroll arrows to display the isotope you want, touch the
isotope name to highlight it and then select <Enter>. The isotope you have selected is now
displayed on the Half Life Verification screen, including the system defined Half Life.
6. Select <Set Test Parameters> to display the Half Life Verification parameters.
(See figure 1.3.)
ATOMLAB DOSE CALIBRATOR 500, 500PLUS AND WIPE TEST COUNTER ADDENDUM
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Figure 1.3. Half Life Verification Setting Test Parameters screen.
7.
Select either <2> or <3> for the number of readings. If the number is already highlighted,
you do not need to select it. (See figure 1.3.)
8. Use the up/down arrows <▲ ▼> to set the time between readings. If the number displayed
is what you desire for your test, you do not have to adjust it. The time can be adjusted
between 1 minute and 60 minutes. Select <Enter Lot Number> if you want to enter a lot
number for this test. When you select <Enter Lot Number>, the alpha numeric keyboard is
displayed. Once you have entered the desired lot number, select <Enter>.
9. The Half Life Verification screen is displayed with the parameters you have selected. Select
<Enter> to proceed to the screen to start the verification test.
10. If desired, select <Zero Background> along the bottom menu. This brings you to the Zero
Background screen. Select <Zero Background> and the background count will begin. If
there has been no activity in the chamber, it will immediately say “completed” and take you
back to the Half Life Verification screen.
11. Place the isotope sample into the dose calibrator chamber.
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Figure 1.4. Half Life Verification for 2 Activity Readings.
Figure 1.5. Half Life Verification Counting screen.
12. Select <Start Recording> to take the first reading. The program will automatically record
the first activity and record the next activity reading at the time you have programmed.
Leave the source in the chamber and the system will complete the test. The time
remaining is displayed for each reading.
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13. If you select <Abort Recording> the test you have started counting will be aborted and take
you back to the Half Life Verification screen. You can restart the test by selecting
<Start Recording>. If you need to change your test parameters or isotope, you can do it at
this point. (See figure 1.5.)
14. When ready select <Start Recording>. The Half Life Verification APP will begin.
NOTE: If you select <End Recording>, the Half Life Verification APP will end and use the elapsed
time for the calculation. If the counting time is not long enough, it could affect the results. It is
recommended to have the count complete the preset time.
Figure 1.6. Two Count Half Life Verification Results screen.
15. When the test is complete, the results are shown on the screen. The results include the
calculated Half Life and the variance percent from the published Half Life of the isotope.
Select <Print> to print your results (See figure 1.8.) If you select <Back>, a message will be
displayed that if you proceed your data will be lost. Select <No> not to exit; select <Yes>
to exit and lose the test data.
16. If you desire to start another Half Life Verification, you must select <Set Test Parameters>
and review the parameters and then select <Enter>. At this point you can start another
test.
17. To perform a three reading test, it is performed the same way as the two reading test
except that three readings will be taken at the time interval you have set. When the test is
complete, the system calculates the Half Life between the first and second reading,
between the second and third reading, and between the first and third reading and shows
the average Half Life for the readings. The variance to the listed preset isotope Half Life is
calculated. To return to the Home screen, select <Back> and then <Home>.
(See figures 1.7 and 1.9.)
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Figure 1.7. Three Reading Half Life Verification Results.
18. After the APP ends you can print the report for the half life verification. Select <Print> and
the three reading report prints. (See Figure 1.9.)
NOTE: The system does not store the half life calculation. You must print the results.
ATOMLAB DOSE CALIBRATOR 500, 500PLUS AND WIPE TEST COUNTER ADDENDUM
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Figure 1.8. Printout For Two Count Half Life Verification Results.
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Figure 1.9. Printout For Three Count Half Life Verification Results.
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Formula for Calculating Half Life
d = measurement
d start = starting measurement
d end = ending measurement
calculate Half Life = log 10 (2.0) x d time
log 10 (d start/d end)
Example for F-18:
starting measurement:
ending measurement:
counting time:
4122
3860
10 min
calculate Half Life = log 10 (2.0) x 10 min
log 10 (4122 / 3860)
=
3.0103 min
0.0285207
=
105.54796 min / 60
calculate Half Life = 1.759 hr
Variance Formula
Half Life Variance = calculated Half Life – isotope Half Life
Isotope Half Life
x 100
Example for F-18:
Half Life Variance = 1.76 – 1.83
1.83
x 100
Half Life Variance = 3.8% lower
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2. Dose Calibrator Settable Background
Counting Time
The background counting time used for the dose calibrator and Zero Background can now be
set for 30, 60 or 100 seconds. In previous software versions background count was fixed at
100 seconds.
This background counting time is used for the dose calibrator Zero Background and Moly Assay
Background counting time.
Adjusting the Background Counting Time:
(See Figures 2.1 and 2.2.)
1. At the Home screen, select <Utilities>.
2. On the Utilities screen, select <Dose Calibrator Configuration>.
3. On the Dose Calibrator Configuration screen, select <Set Background Time>.
Figure 2.1. Dose Calibrator Configuration screen.
ATOMLAB DOSE CALIBRATOR 500, 500PLUS AND WIPE TEST COUNTER ADDENDUM
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Figure 2.2. Set Background Time.
4. You will now have to enter the system’s password to proceed.
5. Set Background Time screen is now displayed. The center of the screen displays the current
Background Time in seconds (30, 60 or 100). By selecting the current setting a pull down
menu is displayed and you can choose a new background counting time. Then select
<Enter>.
NOTE: The factory default background count time is 30 seconds. If you are measuring
sources less than 20 µCi of Tc-99m, increasing background count time to 100 seconds will
improve accuracy.
6.
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Select <Enter> to return to the Dose Calibration Configuration screen. The background
counting time is now changed. Select <Home> to return to the Home screen.
Biodex Medical Systems, Inc. © 2012
3. Moly Assay for the Atomlab Dose Calibrator
(See Figures 3.1, 3.2, 3.3 and 3.4.)
Figure 3.1. Nuclear Pharmacy screen.
NOTE: The update to the Moly Assay Program allows the user to change the Background
Counting Time when starting the Moly Assay test.
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Figure 3.2. Moly Assay Background screen.
To Perform a Moly Assay Test:
1. At the Home screen select <Nuclear Pharmacy>.
2. Select <Moly Assay> to start the Moly Assay Test.
3. The Moly Assay Background screen allows the user to change the background counting
time. The screen displays the current background time. To change the background counting
time, select <Change Background Time>. A message will be displayed stating, “Changing
Background Time Will Be Retained And Have A Global Effect Throughout The System.”
Select <Continue>.
NOTE: If you do not want to change the background time, select <Cancel> and go to Step 5.
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Figure 3.3. Set Background Time screen.
Figure 3.4. Set Background Time.
ATOMLAB DOSE CALIBRATOR 500, 500PLUS AND WIPE TEST COUNTER ADDENDUM
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NOTE: When you change the background counting time it changes the Moly Background Time
and the Dose Calibrator background counting time.
4.
The Set Count Background Time screen is displayed. (See figure 3.4.) Select the number
after Background Count Time. A pull-down menu is displayed with 30, 60 or 100 seconds.
Select to highlight the time that you desire and select <Enter>. The Moly Assay Background
Counting screen will be displayed with the new background counting time. (See figure 3.5.)
Figure 3.5. Moly Background Reading
5.
Select <Zero Background> to begin a background count time lasting 30, 60 or 100 seconds
depending on what you have selected for your background time. Once the zero
background is completed the Moly Assay Test continues as instructed in the Atomlab 500
manual.
NOTE: See Atomlab 500 manual Chapter 5 for Moly Assay.
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4. Dose Calibrator Additional Isotope
Radium 223 has been added to the Dose Calibrator Isotope List.
Symbol:
Ra-223
Dial Value:
17.8
Half Life:
11.43 days
Dial value determined using a standard from Algeta.
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5. Atomlab Wipe Test Counter
Additional Isotopes
The two (2) isotopes added to the Factory Isotope List are Lu-177 and Ra-223.
The Factory Preset Region of Interest (ROI) and the Isotope Efficiency are included in the
Wipe Isotope List.
Isotope Name
Lu-177
Ra-223
Region of Interest (ROI)
37-360 KeV
40-430 KeV
Efficiency
7.8%
135.9%
These isotopes can be added to your wipe test locations following the procedures listed in your
Atomlab Wipe Test manual.
The software update will add the Lu-177 and Ra-223 into the Alphabetical Isotope List.
(See Figure 5.1.)
Figure 5.1. Alphabetic Isotopes List.
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Atomlab Wipe Test Counter Isotope List
Analytically Determined Detector Efficiencies
Please refer to this table below for Analytically Determined Detector Efficiency (%) settings on
the Atomlab Wipe Test Counter. Well Efficiency settings that have an * are empirically
measured.
Left
Right
Half
Well
Wide Window (25-800 keV)
ROI
ROI
Life
Efficiency %
Efficiency %
Am-241
50
69
434.7 yrs
35.7
-Au-198
349
474
2.69 days
28.0
-Ba-133
305
515
10.54 yrs
*36.8
*83.93
Co-57
85
158
271.77 days
*90.9
*90.9
Co-58
434
933
70.9 days
--Co-60
997
1533
5.271 yrs
*23.03
*26.03
Cr-51
272
368
27.7 days
4.5
-Cs-137
561
761
30 yrs
*12.97
*36.4
F-18
420
600
1.83 hrs
*28.25
-Fe-59
934
1486
44.5 days
3.8
-Ga-67
53
424
3.261 days
53.8
-Hg-197
56
90
2.67 days
89.1
-Hg-203
237
322
46.6 days
44.8
-I-123
134
183
13.2 hrs
75.4
-I-125
23
80
60.14 days
*40
-I-131
309
420
8.04 days
*28.7
*45.19
In-111
146
490
2.807 days
*60.0
*70.0
Ir-192
250
703
73.83 days
--K-42
1296
1754
12.4 hrs
--Lu-177
37
360
6.71 days
*7.8%
6.71 days
Na-22
400
600
2.6 yrs
*23.6
*56.59
Na-24
1162
3167
15 hrs
--Pd-103
17
27
10 min
62.3
-Ra-223
40
430
11.43 days
*135.9%
11.43 days
Se-75
102
461
119.8 days
--Sr-85
437
591
64.84 days
18.2
-Tc-99m
119
162
6.007 hrs
*81.66
*83.95
Tc99-Tl-201
50
200
3.046 days
*68.3
-Tl-201
50
100
3.046 days
*50.5
-Yb-169
41
228
32 days
--NOTE: It is recommended that users use the Empirical testing procedures for setting detector
efficiency.
Isotope
ATOMLAB DOSE CALIBRATOR 500, 500PLUS AND WIPE TEST COUNTER ADDENDUM
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ATOMLAB DOSE CALIBRATOR 500, 500PLUS AND WIPE TEST COUNTER ADDENDUM
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BIODEX
Biodex Medical Systems,
Biodex Medical Systems, Inc.
20 Ramsey Road, Shirley, New York, 11967-4704, Tel: 800-224-6339 (Int’l 631-924-9000), Fax: 631-924-9241, Email: info@biodex.com, www.biodex.com
Inc. © 2012