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Membrane transport in flux: the ambiguous
interface between channels and pumps
Papers of a Discussion Meeting Issue organized and edited by F. M. Ashcroft,
D. Gadsby and C. Miller
Contents
Introduction
Introduction. The blurred boundary between channels and transporters
F. Ashcroft, D. Gadsby and C. Miller
145
Articles
The molecular logic of sodium-coupled neurotransmitter transporters
E. Gouaux
149
Interactions of alkali cations with glutamate transporters
D. C. Holley and M. P. Kavanaugh
155
Enhanced activity of human serotonin transporter variants associated with autism
H. C. Prasad, J. A. Steiner, J. S. Sutcliffe and R. D. Blakely
163
A provisional transport mechanism for a chloride channel-type ClK/HC exchanger
C. Miller and W. Nguitragool
175
Proton-coupled gating in chloride channels
J. Lı́sal and M. Maduke
181
Leaky ClK–HCO3K exchangers: cation fluxes via modified AE1
J. C. Ellory, H. Guizouarn, F. Borgese, L. J. Bruce, R. J. Wilkins and G. W. Stewart
189
CLC-mediated anion transport in plant cells
A. De Angeli, D. Monachello, G. Ephritikhine, J.-M. Frachisse, S. Thomine
F. Gambale and H. Barbier-Brygoo
195
The mammalian proton-coupled peptide cotransporter PepT1: sitting on the
transporter–channel fence?
D. Meredith
203
Proton-coupled protein transport through the anthrax toxin channel
A. Finkelstein
209
The structure of the NaC,KC-ATPase and mapping of isoform differences
and disease-related mutations
J. P. Morth, H. Poulsen, M. S. Toustrup-Jensen, V. R. Schack, J. Egebjerg,
J. P. Andersen, B. Vilsen and P. Nissen
217
Peering into an ATPase ion pump with single-channel recordings
D. C. Gadsby, A. Takeuchi, P. Artigas and N. Reyes
229
143
Downloaded from http://rstb.royalsocietypublishing.org/ on March 6, 2016
144
Contents
Structure and mechanism of ATP-binding cassette transporters
K. P. Locher
239
ATP hydrolysis-driven gating in cystic fibrosis transmembrane conductance regulator
D. Muallem and P. Vergani
247
SUR1: a unique ATP-binding cassette protein that functions as an ion channel regulator
J. Aittoniemi, C. Fotinou, T. J. Craig, H. de Wet, P. Proks and F. M. Ashcroft
257
KCNJ11 knockout morula re-engineered by stem cell diploid aggregation
T. J. Nelson, A. Martinez-Fernandez and A. Terzic
269