Ocular Anatomy Intermediate Learning Objectives: 1. Correctly identify ocular structures around or within the eye 2. List the key functions of various ocular structures 3. Accurately point out key external landmarks on, or around the eye 4. Name major bones of the orbit that surround the eye 5. List the six extraocular muscles that control eye movement 6. Accurately identify key ocular structures that compose the visual pathway Lecturer: M. Patrick COLEMAN, ABOC, COT Topics to be covered: Let’s get oriented first… • Superior = UPWARD (or TOP) • 3 Major Layers (Tunics) of the Eye • Ocular Media • Inferior = DOWNWARD (or BOTTOM) • Ocular Adnexa • Nasal / Medial = TOWARD NOSE • The Bony Orbit • Temporal / Lateral = TOWARD TEMPLE • Extraocular Muscles (EOMs) • Posterior = BEHIND (or Toward the BACK) • Visual Pathway • Anterior = IN FRONT (or Toward the Front) FIBROUS TUNIC 3 Major Layers (Tunics) of EYE • FIBROUS TUNIC • Protective layer of eye • Tough & fibrous • UVEAL TRACT or (Vascular Tunic) • Two parts: – Cornea • NERVOUS TUNIC – Sclera 1 Fibrous Tunic: Cornea Fibrous Tunic (cont.): Layers of the Cornea • Anterior 1/6th of the fibrous tunic • Clear; Avascular; approx. +40.00D power • 5 layers: Just remember ABCs… – Epithelium (“A”pithelium?) – Bowman's Membrane – Stroma (“C”troma? Like ceiling…) • Dua’s Layer (Sixth layer? Reported in May 2013) – Descemets Membrane – Endothelium Fibrous Tunic (cont.): Sclera • White in color (appears bluish in infants) • Avascular (without blood vessels; (what look like blood vessels in the sclera are really in the EPISCLERA which lays on top of the sclera) • Makes up posterior 5/6th of fibrous tunic • Very tough! • Cornea & sclera are the “same” material! UVEAL TRACT (cont.): Iris, Ciliary Body, Choroid… UVEAL TRACT (Vascular Tunic) • IRIS (colored part of eye) • CILIARY BODY (behind iris) • CHOROID (can see it on retinal photos, and OCT scans of the retina!) UVEAL TRACT (cont.): IRIS • Color of iris dependent on amount of pigment – Very little pigment = BLUE EYE – Medium amount of pigment = HAZEL EYE – Heavy amount of pigment = BROWN EYE • “Hole” in center of iris regulates amount of light entering the eye…what’s it called? • Dilator muscles vs. Sphincter muscles 2 UVEAL TRACT (cont.): Ciliary Body • Located just behind the iris, at its base UVEAL TRACT (cont.): Ciliary Body • Ciliary Processes produces aqueous humor constantly (keeps our eye ‘filled’ with fluid so it remains “inflated”) • Ciliary Muscles control the focusing of the lens – When the ciliary muscles RELAX, they pull the zonules tight, making the lens thinner, so we can see FAR. – When the ciliary muscles CONTRACT, they release the tension on the zonules so the lens can grow thicker, (causing us to focus, or accommodate) allowing us to see things that are NEAR. UVEAL TRACT (cont.): CHOROID UVEAL TRACT (cont.): CHOROID • Supplies blood to the iris, ciliary body, inner retina & inner sclera • The “CHOW HALL” of the eye - brings nourishment & oxygen – “Sandwiched” between the SCLERA and the RETINA NERVOUS TUNIC The Retina…really! That’s it. Retina • Retina lines posterior 2/3rds of the inner eye • 10 layers thick; all the layers are transparent except the RPE (retinal pigment epithelial) layer • Retina lies on top of the choroid • It’s in contact with the vitreous humor (fluid) • Contains cells that respond to light (photoreceptors); two (2) types – CONES & RODS • It is a NEURAL CONNECTION TO THE BRAIN; often considered an extension of the brain! (It’s directly connected to the II CN, which is the Optic Nerve.) Nervous Tunic (i.e., RETINA) 3 Nervous Tunic (i.e. RETINA) cont. Nervous Tunic (i.e. RETINA) cont. Retina has 10 layers ------------------It’s in-between the VITREOUS & CHOROID ------------------Key layers? – – – Retinal NFL Photoreceptor RPE Retinal Detachment? Most likely to occur where RPE & Photoreceptors come together! Nervous Tunic (i.e. RETINA) cont. • The photoreceptor layer contains the RODS & CONES • Rods & Cones convert light into an electroelectro-chemical impulse – That gets passed along the ganglion cells, to the nerve fiber layer (NFL) – Then it goes to the brain via the Optic Nerve (II CN) • Rods & Cones only “sense” wavelengths in the visible Y G. BIV) which is between: electromagnetic spectrum (ROY 390nm (VIOLET) to 750nm (RED). Nervous Tunic (i.e. RETINA) cont. • CONES are for bright (photopic) conditions; can see color & fine detail – There are approximately 6 million cones in the retina – The fovea centralis (center of Macula) contains ONLY CONES! – Cones emit a chemical called IODOPSIN Trivia Question: • What percentage of MEN are “colorblind”? • What percentage of WOMEN are “colorblind”? Nervous Tunic (i.e. RETINA) cont. • RODS are for dim (scotopic) conditions; They provide a poor image but have a great ability to sense movement – There are approximately 120 million rods in the retina. – Rods emit a chemical called RHODOPSIN Nervous Tunic (i.e. RETINA) cont. • The retina is CLEAR, with the exception of the Retinal Pigment Epithelium (RPE) layer which, like the iris, contains pigment TRIVIA QUESTION: * You enter a dark movie theater. How long does it take RODS to kick in so you can start to ‘see’? ** Who adapts quickest – kids or the elderly? – The RPE layer is the “garbage man”: • It absorbs excess light – AND • It must remove the chemicals emitted by the rods (rhodopsin) and cones (iodopsin) as these chemicals are TOXIC TO THE RETINA. 4 Nervous Tunic (i.e. RETINA) cont. • The layer closest to the vitreous humor is the RETINAL NERVE FIBER LAYER (NFL) • This layer contains the nerves coming from every part of the retina • At the optic nerve, the nerve fiber bundles are most concentrated superiorly & inferiorly • Ever do an OCT scan of the area around the optic nerve head (ONH) of a glaucoma patient? Why? Nervous Tunic (i.e. RETINA) cont. • As the nerve fibers approach the optic disk, they start to bundle closer together and form the cable to the brain we call the OPTIC NERVE (II CN) • In GLAUCOMA, these nerve fibers die off So that’s it, right? HARDLY! • The TUNICS of the eye are just “layers” of the main functional components. • There are many other “parts” that make up the eye and help it work correctly. • Time to look at the “rest of the eye”… Zeiss OCT scan of optic nerve head (ONH) of both eyes: Green = GOOD Yellow = BORDERLINE Red = BAD (glaucoma?!) Nervous Tunic (i.e. RETINA) cont. • 9/10ths of the Retinal blood supply comes from the CENTRAL RETINAL ARTERY (CRA) OCULAR MEDIA • These are the clear structures of the eye light must pass through to get to the retina. • They are the: – CORNEA – AQUEOUS HUMOR – LENS – VITREOUS HUMOR 5 OCULAR MEDIA - Cornea (cont.) • Cornea – Needs a good tear layer to transmit light well – Good quality tears have three parts: OCULAR MEDIA (cont.): TEAR FILM • Lipid (oil) layer (top/outermost layer) - keeps aqueous layer from evaporating away too quickly • Aqueous layer (middle layer) - water portion of tear (thickest layer!) • Mucin (mucous) layer (innermost/against cornea) - keeps tears ‘stuck’ against cornea OCULAR MEDIA – Aqueous Humor (cont.) OCULAR MEDIA – Aqueous Humor (cont.) • AQUEOUS HUMOR – Produced by the CILIARY BODY in “posterior chamber” of the eye’ – Flows thru the pupil into “anterior anterior chamber” chamber – Provides nourishment to Endothelial layer of the cornea & maintains “pressure” in the eye – Drains thru the TRABECULAR MESHWORK and into the CANAL OF SCHLEMM, dissipating into the layers of the sclera OCULAR MEDIA – Lens (cont.) OCULAR MEDIA – Lens (cont.) • Lens (sometimes called the “Crystalline Lens”) – Three parts: • CAPSULE • CORTEX • NUCLEUS – Changes shape to focus images on retina – Soft & flexible in the young; harder as we age – Cataracts form in this structure (BUMMER!) – Approximately +18.00D to +21.00D of power 6 OCULAR MEDIA - Vitreous (cont.) OCULAR MEDIA – Vitreous (cont.) • VITREOUS HUMOR – Fills the posterior 5/6ths of the eye – When we are young, young it is thick and “jello-like” – As we age, it breaks down and becomes more watery. It also tends to ‘shrink’ a bit causing PVDs (post-vitreous detachments) floaters” it is usually debris in the – When we see “floaters vitreous that’s moving around – What you have is all you get. If you lose vitreous, the body will NOT make more! So is that it? As they say on TV, “But wait! There’s More!!!” OCULAR ADNEXA • Eyelids & Landmarks • Ocular Adnexa • Muscles of the eyelids • The Bony Orbit • Tarsal Plate & Glands • Extraocular Muscles (EOMs) • Conjunctiva & Lacrimal System EYELIDS & LANDMARKS LANDMARKS of the EYELIDS • Eyelids are the folds of tissue that cover the eye itself. Their primary purpose is… – PROTECTION!!! – Limit amount of light entering the eye (giving the pupil a nice assist at times) – Keep dust & dirt out of the eye (& fingers & racquetballs & fish hooks and…well, you get the idea!) – Eyelashes = ‘early warning’ sensors • (Which lid has MORE lashes? UPPER or lower?) 7 EYELIDS & LANDMARKS (cont.) • MUSCLES of the EYELIDS – Muscles open & close the lids (duh!) – To OPEN the lids, we use the: • LEVATOR PALPEBRAE SUPERIORIS (let’s just go with “LEVATOR”!) and the • MUSCLE OF MUELLER – The III CN (Oculomotor nerve) “operates” these nerves – Which muscle is the PRIMARY worker here? LEVATOR PALPEBRAE SUPERIORIS (LEVATOR)! • A way to remember? • Mueller gets on the LEVATOR to go UP & fix the oculoMOTOR on the 3rd (III) floor • Levator OPENS the eyelids – Mueller helps – III CN (Oculomotor nerve) controls them both EYELIDS & LANDMARKS (cont.) • MUSCLES of the EYELIDS (cont.): – To CLOSE the lids, we use the: • ORBICULARIS OCULI muscle and the… • RIOLAN’S muscle – The VII CN (Facial nerve) “operates” these two muscles ORBICULARIS OCULI ! • It is the primary muscle for closing the eyelid • Just remember: Orbicularis Oculi CLOSES the eye! QUESTION: Which is the “PRIMARY” muscle for closing the lids? EYELIDS & LANDMARKS (cont.) EYELIDS & LANDMARKS (cont.) • TARSAL PLATE: – Levator & Mueller’s muscle attach to this – It is considered the “skeleton skeleton” of the lid as it’s made up of tough, fibrous tissue – When the doctor “everts everts” the lid to look for a foreign body (FB) or wayward contact, they are pushing at the top of the TARSAL PLATE to get the lid to flip inside out 8 TARSAL PLATE IN THE LID OCULAR ADNEXA (cont.) - GLANDS • GLANDS – The adnexa (eyelids & surrounding structures) contain GLANDS that secrete OIL or AQUEOUS • SEBACEOUS GLANDS secrete OIL • LACRIMAL GLANDS secrete AQUEOUS OCULAR ADNEXA (cont.) - Glands OCULAR ADNEXA (cont.) - Conjunctiva • CONJUNCTIVA – Thin, saran-wrap-like layer on the surface of your sclera and inner eye lids • TWO PARTS: PALPEBRAL & BULBAR • Where the two parts meet is called the FORNIX – Protection; Protection barrier to infection; keeps things from getting ‘behind’ the eye – Contains GOBLET CELLS that secrete MUCIN OCULAR ADNEXA (cont.) - Conjunctiva OCULAR ADNEXA (cont.) – Lacrimal System • LACRIMAL SYSTEM – These are all the structures involved in the production, distribution, & disposal of tears – SEVEN (7) distinct structures: • 1) Lacrimal Gland • 2) Lacrimal Canal (Ducts) • 3) Conjunctival Sac • 4) Puncta (upper and lower) • 5) Canaliculi • 6) Lacrimal Sac • 7) NasoLacrimal Duct 9 OCULAR ADNEXA (cont.) LACRIMAL SYSTEM: THE BONY ORBIT • Additus Orbitae (the opening of the bony orbit) • The bony orbit is composed of seven (7) bones that surround the eye to protect it & provide passage or attachment points for various structures (like the eye muscles, nerves, nerves fat, lacrimal gland and vascular supply) • Bony orbit is comprised of a: – ROOF (lesser wing of SPHENOID & FRONTAL) – FLOOR (MAXILLA, PALATINE, & ZYGOMATIC) – LATERAL WALL (ZYGOMATIC & greater wing of SPHENOID) – MEDIAL WALL (MAXILLA, ETHMOID, LACRIMAL & lesser wing of SPHENOID) THE BONY ORBIT (cont.) THE BONY ORBIT (cont.) • ROOF: (Light Shines From the roof) – Lesser wing of Sphenoid (foramina for optic nerve [II CN] to pass through!) – Frontal bone (fossa for lacrimal gland) • FLOOR: (MoP Zee floor) – Maxilla (blow out fractures!) – Palatine (smallest bone) – Zygomatic (strongest bone) THE BONY ORBIT (cont.) • LATERAL WALL: (Zee Great Side!) – Zygomatic (strongest) – Greater wing of Sphenoid • MEDIAL WALL: (Eat @ M E L L S) – – – – Maxilla (blow out fractures!) Ethmoid (thinnest bone) Lacrimal (fossa for the lacrimal sac) Lesser wing of Sphenoid (foramina for optic nerve [II CN] to pass through!) THE BONY ORBIT (cont.) • Cracks, Holes, & Depressions…OH MY! – Fissures = cracks in bones (the Superior Orbital Fissure allows the III, IV, V, and VI cranial nerves [CN] access to the bony orbit) – Foramina/Foramen = holes in bones (the Optic Foramina is the hole in the lesser wing of Sphenoid that the optic nerve [IICN] passes through) – Fossa/Fossae = depressions (“dents”) in bones (Lacrimal Fossa is a dent in the lacrimal bone where the lacrimal sac sits) 10 THE BONY ORBIT (cont.) EXTRAOCULAR MUSCLES • SIX (6) muscles for each eye • They attach to the sclera of the eye • “Job” is to move the eyes to keep objects of interest lined up with the macula of each eye – Goal is: Single Binocular Vision (SBV) – Want to avoid: diplopia or suppression resulting in monocular vision. • “Primary Position of Gaze” = Straight Ahead EXTRAOCULAR MUSCLES (cont.) EXTRAOCULAR MUSCLES (cont.) • There are four Rectus muscles for each eye: Lateral Rectus (LR), Medial Rectus (MR), Superior Rectus (SR), & Inferior Rectus (IR) – Rectus muscles attach ANTERIOR to the equator; because of that, they pull the eye in the direction of their name: • Lateral Rectus (LR) pulls eye laterally (OUT), or ABDUCTION • Medial Rectus (MR) pulls eye medially (IN), or ADDUCTION • Superior Rectus (SR) pulls eye superiorly (UP), or ELEVATION • Inferior Rectus (IR) pulls eye inferiorly (DOWN), or DEPRESSION EXTRAOCULAR MUSCLES (cont.) • There are two (2) OBLIQUES muscles for each eye. • OBLIQUES are “unique unique”; they move the eyes OPPOSITE of what they “say”… • SUPERIOR OBLIQUE (SO) makes the eye look inferiorly (Depression) and across the nose (intorsion intorsion) • INFERIOR OBLIQUE (IO) makes the eye look superiorly (Elevation) and across the nose (extorsion extorsion) EXTRAOCULAR MUSCLES (cont.) • ExtraOcular Muscles (EOMs) are ‘innervated’ by cranial nerves (nerves make the muscles work!) • Which nerves ‘operate’ which muscles? LR6 SO4 3 What!? • Lateral Rectus = VI (6th) CN (Abducens) • Superior Oblique = IV (4th) CN (Trochlear) • All the rest = III (3rd) CN (Oculomotor) 11 EXTRAOCULAR MUSCLES (cont.) • Our eyes are YOKED” “YOKED together. • The OD can’t look up while the OS looks down! • Where one eye goes, the other follows… IS YOUR BRAIN FULL YET? So far, we have covered… • The three layers (or Tunics) Tunics of the eye: FIBROUS TUNIC, UVEAL TRACT or (Vascular Tunic), and the NERVOUS TUNIC • -------------------------------------------------------• The Ocular Media: CORNEA, AQUEOUS HUMOR, CRYSTALLINE LENS, LENS & VITREOUS HUMOR • -------------------------------------------------------• And then the… Ocular Adnexa, Adnexa The Bony Orbit, and the Extraocular Muscles Next, the Visual Pathway The body has AFFERENT neurons (nerves) that carry ‘sensory’ messages to the brain (like like sight!) sight! • The visual pathway is an afferent message to the brain; The seven (7) parts of the afferent pathway: 1. RETINA 2. OPTIC NERVE 3. OPTIC CHIASM 4. OPTIC TRACT 5. Lateral Geniculate Body (LGB) 1. OPTIC RADIATIONS 2. VISUAL CORTEX Remember, images that hit the retina are upside down & backwards… Here is another way to look at the Afferent (visual) pathway -----------Notice how 50% of the visual ‘message’ crosses over to the other side of the head at the OPTIC CHIASM! CHIASM Afferent (visual) pathway (cont.) Why do you care? • Think about the tests you run on patients: – Visual Acuity (VAs) – Visual Fields (VFs) – Cover Testing (CT) – Extra Ocular Motility (EOMs) – Pupillary Response • These all rely on an intact & functioning AFFERENT (Visual) Pathway! 12