INTRODUCTION TO GENERAL, ORGANIC, & BIOCHEMISTRY, CHEM-30B, WINTER 2013 INSTRUCTOR: DR. RAM SUBRAMANIAM Instructor Contact Information Dr. Ram Subramaniam Office: SC 1222 De Anza College, Cupertino, CA Email: subramaniamram@deanza.edu Phone: 408-864-8517 Office Hours: Tuesday- 1:30 to 2:30 p.m. and Thursday- 4:30 to 5:30 p.m. Class Meeting Lecture: SC 2210; Tu, Th- 5:30 to 7:10 p.m. Lab lecture & Lab: SC 2210; Tu 2:30-5:20 p.m. Textbook Lecture- Chemistry, An Introduction to General, Organic, and Biological Chemistry, Karen C. Timberlake, Tenth Edition, Pearson, Prentice Hall, ISBN-13: 978-0-13-6019701, ISNB-10: 0-13-601970-6 Lab-­‐ Introduction to General, Organic, and Biochemistry, Karen Timberlake, Prentice Hall, ISBN: 1-­‐256-­‐17651-­‐6 Course Content In this class we will discuss fundamental topics in General, Organic, and Biochemistry. These courses are designed to prepare a student for a career in a health-related field. We will begin with a discussion of fundamental topics in organic chemistry and study the nomenclature, structure, and simple reactions of hydrocarbons, alcohols, aldehydes, ketones, carboxylic acids, and esters. Following this we will introduce some topics in biochemistry including: carbohydrates, lipids and fats, amino acids and proteins, and nucleic acids. Learning Outcomes 1. Differentiate the general reactions of the principle organic functional groups. 2. Evaluate the major classes of biological compounds from a chemical perspective. Academic Integrity All graded assignments must be completed without any consultation (people, books, internet) unless otherwise permitted by the instructor. Any student that violates this policy will receive a failing grade (F) in the class and reported to appropriate administrative authorities such as the Dean. Attendance Policy Failure to attend any of the lectures or laboratory classes during the first two weeks will result in you being dropped from the class. You are expected to attend all lecture and laboratory classes. Strong evidences exist that indicate that the success of a student is directly related to her/his class attendance. You will be given an “F” grade for unexcused absences in TWO or more lecture and/or laboratory periods. Excused Absence: If you know in advance that you will need to miss a class, please notify the instructor and provide proof of the excuse. If you have already missed a class, please follow up with the instructor as soon as possible and provide a proof of a valid excuse. Valid excuses are: birth/death in the family, work-related travel, illness/medical emergencies, conference travels, jury duty, accidents, legal issues, or traveling to represent De Anza College at meetings/other events. Other excuses will be considered on a case-by-case basis. Please note that verifiable documented proof of the excuse is essential in order to grant a make-up. Cell Phone Policy Use of cell phones is strictly prohibited during class. There is to be no text messaging, browsing the Internet, or voice conversations. Violation of this policy will bar you from attending office hours and may result in failure in the class. Evaluation The lecture portion of the class is weighted at 80% and the laboratory portion is 20%. There will be six quizzes, three exams, an assignment, and a final exam in the lecture. There are a total of nine laboratory experiments. You must complete all the lab experiments in order to pass the class. The evaluation for the laboratory part will consist of lab reports, lab exams, attendance, and notebook. Lecture Schedule The following is a tentative schedule for the lecture portion of the class. It is highly recommended that you read the relevant sections in the book prior to the lecture. Periodically, the instructor may assign certain sections of the book to be read on your own and these will not be covered in the lecture. You will receive appropriate instruction for such readings during the lecture. Some laboratory periods may be used for lectures. Class Period 1/8 1/10 1/15 1/17 1/22 1/24 1/29 1/31 2/5 2/7 2/12 2/14 2/19 2/21 2/26 2/28 3/4 3/6 3/11 3/13 3/18 3/20 Topics Alkanes Alkenes Quiz 1 (Chapter 10) Alcohols, Thiols, Ethers Exam 1 (Chapters 10 and 11) Carboxylic Acids, Esters, Amines, Amides Quiz 2 (Chapter 12) Carbohydrates Quiz 3 (Chapter 13) Review Exam 2 (Chapters 12, 13, 14) Lipids Quiz 4 (Chapter 15) Amino Acids, Proteins, Enzymes Quiz 5 (Chapter 16) Nucleic Acids and Protein Synthesis Exam 3 (Chapters 15, 16) Metabolism Quiz 6 (Chapter 17) Metabolism Lab Exam Sections Chapter 10 Chapter 11 Chapter 12 Chapter 12/13 Chapter 14 Chapter 12/13/14 Chapter 15 Chapter 16 Chapter 17 Chapter 18 Chapter 18 Grading Lecture: 800 points Exams 3 × 100 = 300 points Quizzes 5 × 50 = 250 points Participation 1 × 50 = 50 points Final Exam 1 × 200 = 200 points Lab: 200 points Pre-lab 9 × 5 = 45 points Lab report 9 × 10 = 90 points Lab exam 1 × 65 = 65 points Grading Scale In order to obtain the final letter grade for the class, your total lecture score will be added to your lab score and a percentage score will be computed based on the total. This percentage score will be rounded to the nearest whole number and a letter grade will be assigned as per the following table. Grades will not be based on a curve. Please note that regardless of your overall score, if you do not complete all the lab assignments you will receive an F grade in the class. Percentage points 96-100 91-95 88-90 85-87 81-84 78-80 73-77 70-72 66-69 63-65 0-59 Grade A+ A AB+ B BC+ C D+ DF Other Options Pass/No Pass: A grade of “C” or higher is considered “Pass” in the course and lower than “D+” is considered “No Pass” in the course. Audit: If you do not need any credit for this course, you may elect to audit the course. Note: You are not permitted to attend this class if you are not officially registered. Lab Safety: The following lab safety rules must be observed at all times while in lab. Failure to comply will result in failure in the class. 1. Chemistry Department-approved safety goggles purchased from the De Anza College bookstore (NOT safety glasses) must be worn at all times once laboratory work begins, including when obtaining equipment from the stockroom or removing equipment from student drawers, and may not be removed until all laboratory work has ended and all glassware has been returned to student drawers. 2. Closed-toed shoes that completely enclose the foot are to be worn at all times. 3. Shorts, cut-offs, skirts or pants exposing skin above the ankle, and sleeveless tops may not be worn in the lab: ankle-length clothing must be worn at all times. 4. Hair reaching the top of the shoulders must be tied back securely. 5. Loose clothing must be constrained. 6. Avoid wearing jewelry such as rings, bracelets, and wristwatches in the laboratory to prevent chemical seepage in between the jewelry and skin. 7. Eating, drinking, or applying cosmetics in the laboratory is forbidden at ALL times, including during lab lecture. 8. Use of electronic devices requiring headphones in the laboratory is prohibited at ALL times, including during lab lecture. 9. Inform the instructor of any known medical conditions. 10. Be aware of the locations of the eyewash stations, emergency shower, and all exits. 11. No one is allowed in the lab without an instructor being present. 12. Chemicals must never be disposed off into the sink. Dispose chemicals in appropriately labeled waste bottles provided by the instructor. 13. Students are required to follow the De Anza College Code of Conduct at all times while in lab. 14. You are required to wear nitrile gloves while performing lab work. Schedule: The following is a schedule of experiments that will be performed this quarter. Date 1/8 1/15 1/22 1/29 2/5 2/11 2/19 2/26 3/4 3/11 3/18 Topic Introduction and Check-­‐in Hydrocarbons Alcohols & Phenols Aldehydes & Ketones Carboxylic Acids and Esters Carbohydrates Glycerophospholipids Amines & Amides Acetaminophen Peptides & Proteins Check-­‐out