1- Which of the following side effects are produced with T.C.A?
A- Tachycardia & dry mouth.
B- Sedation.
C- Postural hypotension.
D- Both A & C.
E- All of the above.
2- Concerning MAO inhibitors:
A- Selegiline is MAOB inhibitor that is used in treatment of depression.
B- Moclobemide is MAOA inhibitor that is used in treatment of mania.
C- Hypertensive crisis may occur when patients on phenelzine ingest cheese.
D- Both A & C.
E- None of the above.
3- Which of the following effects the T.C.A. & phenothiazines have in common?
A- Blocking dopamine receptors.
B- Increasing serotonin levels.
C- Blocking alpha adrenergic receptors.
D- Both A & B.
E- None of the above.
4 – Concerning selective serotonin reuptake inhibitors:
A- Fluoxetine can be used in treatment of premature ejaculation.
B- They may produce anticholinergic, cardiotoxicity & sedative effects.
C- Fluoxetine is a liver microsomal enzyme inducer.
D- Both A & B.
E- None of the above.
5- Antidepressants can be used in treatment all of the following Except:
A- Nocturenal enuresis.
B- Phobia.
C- Psychosis & aggression.
D- Panic attacks.
E- Endogenous depression.
6- Concerning the mechanism of action T.C.A:
A- Amitryptyline blocks 5-HT & NE reuptake into the nerve terminals.
B- Long-term use of imipramine causes down regulation of beta, alpha2 & 5-HT receptors.
C- T.C.A. with 3ry amine block the reuptake of NE more selectively than 5-HT.
D- Both A & B.
E-All of the above
7- Concerning second generation antidepressants:
A- Mianserin blocks alpha-2 receptors.
B- Maprotiline selectively blocks DA reuptake.
C- They are more potent than T.C.A. but have more side effects.
D- Both A & C.
E- All of the above
8- Concerning MAO inhibitors:
A- Phenelzine may cause hepatotoxicity.
B- Tranylcypromine is a selective MAOA inhibitor.
C- Non-selective drugs have a residual effect after discontinuation.
D- Both A & C.
E-All of the above
9- Concerning second generation antidepressants:
A- Bupropion facilitate dopaminergic transmission.
B- They have similar potency to TCA.
C- They have similar side effects to TCA.
D- Both A & B.
E-All of the above
10- Which of the following drugs have a dual SSRI activity plus blocking 5-HT2
receptors?
A- Nefazodone.
B- Flouxetine.
C- Sertraline.
D- Both A & B.
E-All of the above
T F 1- Depression can be treated with phenthiazines.
T F 2- TCA with tertiary amine structure inhibit reuptake of serotonin more than
norepinephrine.
T F 3- Imipramine is contra-indicated in glaucoma due to blocking of muscarinic
receptors.
T F 4- Acute toxicity of TCA is characterized by muscle paralysis and heart block.
T F 5- Maprotiline is a selective serotonin reuptake inhibitor.
T F 6- Flouxetine has an atropine-like effect.
T F 7- Overdose of SSRI may cause aggressive behaviour and seizures.
T F 8- MAO inhibitors do not cause receptor down-regulation.
T F 9- Concurrent use of moclobemide and tyramine-rich food would cause severe
hypertension.
T F 10- Concurrent use of diazepam and flouxetine may cause excessive sedation.