Cardio # 96 Mon 02/04/03 10am Dr. M. Smith Bryan Massey Proscribe Samera Kasim Page 1 of 3 Venous Return and Cardiac Output I. Coupling of the heart and Circulation a. Cardiac function curve i. This was introduced by Dr. Downey ii. CO v. Preload curve (starling curve) b. Venous Return curve i. Aka vascular function curve ii. 3 things effect it: 1. RAP (right atrial pressure) a. Related to preload b. Defines the curve 2. Mean circulatory filling pressure (MCFP) 3. systemic vascular resistance a. together, #2 and 3 alter the form of the curve II. Vascular function curve a. Venous return v. Venous pressure i. Venous pressure is the same as RAP b. Increasing RAP results in a decr venous return c. Pressure gradient is the key d. As RAP continues to increase, there is less blood flow through the heart and thus less flow through the system. As a result, there is less flow returning to the heart. e. Negative values for RAP creates a suction-like environment that counterbalances the tendency for veins with low pressure to collapse. III. MCFP a. “the equilibrium pressure which prevails in the circulatory system in the absence of blood flow (Q).” -levy i. note, there’s a really good explanation of this in the book that corresponds with fig 29-2, p460. it was recommended that you look at the figure. b. Explanation of the chart: i. The pressure gradient between Pv (venous pressure) and Pa (arterial Pressure) determines Q. ii. At t=0, the heart is functioning properly and Q is normal at 5L/min. pressures are also normal iii. At t = 5, Q has decreased because of fibrillations or cardiac arrest; there is a resultant change in the Pa and Pv. 1. Pv increases because blood is getting “backed up” since it’s not being pumped out 2. Pa is decreasing because it’s not getting much blood pumped out of the heart. Cardio # 96 Mon 02/04/03 10am Dr. M. Smith Bryan Massey Proscribe Samera Kasim Page 2 of 3 iv. At t = 10, Pa and Pv have equilibrated; there is no longer a driving force (pressure gradient) for venous return so Q = 0 1. this is the mean circulatory filling pressure c. What effects MCFP? – 2 things… i. Blood volume (graph) 1. Transfusion (added vascular volume) OR venoconstriction results in increase venous return and increases the MCFP 2. Hemmorrhage or venodilation results in decr venous return and decreases the MCFP value 3. REMEMBER that venous return (or the right atrial pressure) must = cardiac output. ii. Sympathetic activation in the form of venoconstriction OR dilation 1. this is where veins and arteries are different. Most sympathetic nerves go to the arterioles on the arterial side of the system because they’re the big resistors (as explained later this afternoon by Dr. Downey) 2. there is little sympathetic effect on lg arteries, such as the aorta. 3. venous innervation is diffuse and occurs across the entire vessel, thus venoconstriction causes a generalized constriction, resulting in “stiffness” and decrease compliance of the vessel. 4. veins are able to equilibrate with arteries because they are very compliant IV. Vascular compliance curves a. What happens to compliance at MCFP? b. Well, as it was mentioned above, the venous volume increases until it reaches a pressure of 7 and the arterial vol decreases until it reaches a pressure of 7. c. Veins become more distended with incr volume d. It is very important to note that the change arterial volume is VERY SLIGHT. Look at the graph and see how shallow the slope is. V. Arterial compliance curve a. Reiterating what was mentioned above, if you stop Q, the Vascular volume of the arteries will decrease until they reach a pressure of 7 mmHg, wherein they will have equilibrated with the Pv. b. Clinically, we increase the blood volume (or vascular volume) in hypotensive pts. i. Note, the fluid does not have to be blood; it could be plasma, etc. VI. Vascular function curve Cardio # 96 Mon 02/04/03 10am Dr. M. Smith Bryan Massey Proscribe Samera Kasim Page 3 of 3 a. Demonstrates the effect of systemic vascular resistance i. Ex: An increase in R decr Q, resulting in decr Venous Return and decr CO (this is all a chain of events…) ii. Homeostasis occurs upon vasoconstriction b. Graph (slide #11) – decrease vascular R (vasodilation) or incr vascular R (vasoconstriction) does not change MCFP c. At the arterial level, vasoconstriction slows Q, thus slows venous return d. Stated another way, in the presence of vascular resistance, Q is altered (decr) in able to maintain Cardiac Output. VII. Coupling of Cardiac and Vascular Function a. This is putting together 2 graphs that we should definitely be able to recognize and understand. b. Don’t make superimposing these graphs too complex. They no longer make this too elaborate on the boards. c. The point where the 2 curves intersect is the value for normal CO and venous return. (because of course you know they’re equal at ~5L/min) d. In the event of increase contractility, i. cardiac function improves and the curve shift upward ii. CO, SV, and Venous return increase while the ESV, EDV and Preload decrease 1. remember this is because with constant heart rate and flow, there will be less blood left in the ventricles after systole. 2. if the same amount of blood is coming into the ventricles, but they’re emptier than before, then EDV also decr iii. venous return increases to match CO. e. In the event of a change in blood volume, i. This assumes no change in contractility ii. A hemorrhage (dotted line) would result in decr volume. iii. This pretty much causes everything else to fall too: 1. MCFP, pressure gradient, venous return, preload, and cardiac output would decrease 2. again, CO decreases because it matches Venous return.