RosetteSep Recent Publications
Human T Cell Enrichment (15021, 15061)
Ahn YT, Huang B, McPherson L, Clayberger C, Krensky AM: Dynamic interplay of transcriptional machinery
and chromatin regulates "late" expression of the chemokine RANTES in T lymphocytes.
Mol Cell Biol. 27(1): 253-66, 2007
Atkuri RA, Herzenberg LA, Niemi A, Cowan T, Herzenberg LA: Importance of culturing primary lymphocytes at
physiological oxygen levels. PNAS. 104(11): 4547-4552, 2007
Barragan M, de Frias M, Iglesias-Serret D, Campas C, Castano E, Santidrian AF, Coll-Mulet L, Cosialls AM,
Domingo A, Pons G, Gil J: Regulation of Akt/PKB by phosphatidylinositol 3-kinase-dependent and independent pathways in B-cell chronic lymphocytic leukemia cells: role of protein kinase C{beta}
J Leukoc Biol. 2006 (Epub ahead of print)
Beeton C, Wulff H, Singh S, Botsko S, Crossley G, Gutman G, Cahalan M, Pennington M, Chandy K: A novel
fluorescent toxin to detect and investigate Kv1.3 channel up-regulation in chronically activated T
lymphocytes. J Biol Chem 278: 9928-9937, 2003
Bischoff F, Marqu?-Do D, Martinez D, Dang D, Horne C, Lewis D, Simpson J: Intact fetal cell isolation from
maternal blood: improved isolation using a simple whole blood progenitor cell enrichment approach.
Clinical Genetics 63: 483-489, 2003
Bishop MR, Fowler DH, Marchigiani D, Castro K, Kasten-Sportes C, Steinberg SM, Gea-Banacloche JC, Dean R,
Chow CK, Carter C, Read EJ, Leitman S, Gress R: Allogeneic lymphocytes induce tumor regression of advanced
metastatic breast cancer. J Clin Oncol 22(19): 3886-3892, 2004
Campello S, Lacalle RA, Bettella M, Manes S, Scorrano L, Viola A: Orchestration of lymphocyte chemotaxis by
mitochondrial dynamics. J Exp Med. 2006 (Epub ahead of print)
Carmona EM, Vassallo R, Vuk-Pavlovic Z, Standing JE, Kottom TJ, Limper AH: Pneumocystis cell wall betaglucans induce dendritic cell costimulatory molecule expression and inflammatory activation through a Fas-Fas
ligand mechanism. J Immunol. 177(1): 459-67, 2006
Chang JS, Huggett JF, Dheda K, Kim LU, Zumla A, Rook GA: Myobacterium tuberculosis induces selective upregulation of TLRs in the mononuclear leukocytes of patients with active pulmonary tuberculosis.
J Immunol. 176(5):3010-8, 2006
Cilliers T, Nhlapo J, Coetzer M, Orlovic D, Ketas T, Olson W, Moore J, Trkola A, Morris L: The CCR5 and CXCR4
Coreceptors are both used by Human Immunodeficiency Virus Type 1 primary isolates from subtype C.
J Virol 77: 4449-4456, 2003
Conforti L, Petrovic M, Mohammad D, Lee S, Ma Q, Barone S, Filipovich AH: Hypoxia regulates expression and
activity of Kv1.3 channels in T Lymphocytes: A possible role in T cell proliferation.
J Immunol 170: 695-702, 2003
Frazer-Abel AA, Baksh S, Fosmire SP, Willis D, Pierce AM, Meylemans H, Linthicum DS, Burakoff SJ, Coons T,
Bellgrau D, Modiano JF: Nicotine activates nuclear factor of activated T cell c2 (NFATc2) and prevents cell cycle
entry in T cells. J Pharm Exp Thera 311(2) p758, 2004
Goda C, Kanaji T, Kanaji S, Tanaka G, Arima K, Ohno S, Izuhara K: Involvement of IL-32 in activationinduced cell death in T cells. Int Immunol. 18(2):233-40, 2006
Hayashi T, Hideshima T, Akiyama M, Raje N, Richardson P, Chauhan D, Anderson KC: Ex vivo induction of
multiple myeloma-specific cytotoxic T lymphocytes. Blood 102: 1435-1442, 2003
He X, Draghi M, Mahmood K, Holmes TH, Kemble GW, Dekker CL, Arvin AM, Parham P, Greenberg HB: T celldependent production of IFN-γ by NK cells in response to influenza A virus. J Clin Invest 114, 1812-1819, 2004
Hornell TMC, Beresford GW, Bushey A, Boss JM, Mellins ED: Regulation of the class II MHC pathway in primary
human monocytes by granulocyte-macrophage colony-stimulating factor. J Immunol 171: 2374-2383, 2003
Kremer KN, Kumar A, Hedin KE: Haplotype-Independent Costimulation of IL-10 Secretion by SDF-1/CXCL12
Proceeds via AP-1 Binding to the Human IL-10 Promoter. J Immunol. 178(3): 1581-8, 2007
Laudanski K, Miller-Graziano C, Xiao W, Mindrinos MN, Richards DR, De A, Moldawer LL, Maier RV, Bankey P,
Baker HV, Brownstein BH, Cobb JP, Calvano SE, Davis RW, Tompkins RG: Cell-specific expression and pathway
analyses reveal alterations in trauma-related human T cell and monocyte pathways.
PNAS. 103(42): 15564-9, 2006
Leiba M, Cahalon L, Shimoni A, Lider O, Zanin-Zhorov A, Hecht I, Sela U, Vlodavsky I, Nagler A: Halofuginone
inhibits NF-kappaB and p38 MAPK in activated T cells. J Leukoc Biol. 80(2): 399-406, 2006
Li Y, Harada T, Juang YT, Kyttaris VC, Wang Y, Zidanic M, Tung K, Tsokos GC: Phosphorylated ERM Is
Responsible for Increased T Cell Polarization, Adhesion, and Migration in Patients with Systemic Lupus
Erythematosus. J Immunol. 178(3): 1938-47, 2007
Liu E, Jelinek J, Pastore YD, Guan Y, Prchal JF, Prchal JT: Discrimination of polycythemias and thrombocytes by
novel, simple, accurate clonality assays and comparison with PRV-1 expression and BFU-E response to
erythropoietin. Blood 101: 3294-3301, 2003
Nika K, Charvet C, Williams S, Tautz L, Bruckner S, Rahmouni S, Bottini N, Schoenberger SP, Baier G, Altman
A, Mustelin T: Lipid raft targeting of hematopoietic protein tyrosine phosphatase by protein kinase C thetamediated phosphorylation. Mol Cell Biol. 26(5): 1806-16, 2006
Rao RM, Betz TV, Lamont DJ, Kim MB, Shaw SK, Froio RM, Baleux F, Arenzana-Seisdedos F, Alon R, Luscinskas
FW: Elastase release by transmigrating neutrophils deactivates endothelial-bound SDF-1a and attenuates
subsequent T lymphocyte transendothelial migration. J. Exp. Med. 200(6) p713 2004
Sieling PA, Chung W, Duong BT, Godowski PJ, Modlin RL: Toll-like receptor 2 ligands as adjuvants for human
Th1 responses. J Immunol 170: 194-200, 2003
Tomic J, White D, Shi Y, Mena J, Hammond C, He L, Miller RL, Spaner DE: Sensitization of IL-2 signaling
through TLR-7 enhances B lymphoma cell immunogenicity. J Immunol. 176(6): 3830-9, 2006
Trkola A, Kuster H, Leemann C, Ruprecht C, Joos B, Telenti A, Hirschel B, Weber R, Bonhoeffer S, Gunthard HF,
and the Swiss HIV Cohort Study: Human Immunodeficiency Virus Type 1 fitness is a determining factor in viral
rebound and set point in chronic infection. J Virol 77: 13146-13155, 2003
Wagner CS, Riise GC, Bergstrom T, Karre K, Carbone E, Berg L: Increased Expression of Leukocyte Ig-Like
Receptor-1 and Activating Role of UL18 in the Response to Cytomegalovirus Infection.
J Immunol. 178(6): 3536-43, 2007
Yoshimoto K, Takahashi Y, Ogasawara M, Setoyama Y, Suzuki K, Tsuzaka K, Abe T, Takeuchi T: Aberrant
expression of BAFF in T cells of systemic lupus erythematosus, which is recapitulated by a human T cell line,
Loucy. Int Immunol. 18(7): 1189-96, 2006
Zanin-Zhorov A, Cahalon L, Tal G, Margalit R, Lider O, Cohen IR: Heat shock protein 60 enhances CD4+
CD25+ regulatory T cell function via innate TLR2 signaling. J Clin Invest. 116(7): 2022-32, 2006
Zanin-Zhorov A, Hershkoviz R, Hecht I, Cahalon L, Lider O: Fibronectin-associated Fas ligand rapidly induces
opposing and time-dependent effects on the activation and apoptosis of T Cells.
J Immunol 171: 5882-5889, 2003
Human CD4+ T Cell Enrichment (15022, 15062)
Addo M, Yu X, Rathod A, Cohen D, Eldridge R, Strick D, Johnston M, Corcoran C, Wurcel A, Fitzpatrick C,
Feeney M, Rodriguez W, Basgoz N, Draenert R, Stone D, Brander C, Goulder P, Rosenberg E, Altfeld M, Walker
B: Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses
directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no
correlation to viral load. J Virol 77: 2081-2092, 2003
Blanco J, Bosch B, Fern?dez-Figueras MT, Barretina J, Clotet B, Est?JA: High level of coreceptor-independent
HIV transfer induced by contacts between primary CD4 T cells. J Bio Chem 279(49): 51305-51314, 2004
Chemnitz JM, Driesen J, Classen S, Riley JL, Debey S, Beyer M, Popov A, Zander T, Schultze JL: Prostaglandin
E2 impairs CD4+ T cell activation by inhibition of lck: implications in Hodgkin's lymphoma.
Cancer Res. 66(2): 1114-22, 2006
Cron RQ, Bandyopadhyay R, Genin A, Brunner M, Kersh GJ, Yin J, Finkel TH, Crow MK: Early growth
response-1 is required for CD154 transcription. J Immunol. 176(2): 811-8, 2006
Feeney M, Draenert R, Roosevelt K, Pelton S, McIntosh K, Burchett S, Mao C, Walker B, Goulder P:
Reconstitution of Virus-Specific CD4 Proliferative Responses in Pediatric HIV-1 Infection.
J Immunol 171: 6968-6975, 2003
Fulcher JA, Hashimi ST, Levroney EL, Pang M, Gurney KB, Baum LG, Lee B: Galectin-1-matured human
monocyte-derived dendritic cells have enhanced migration through extracellular matrix.
J Immunol. 177(1): 216-26, 2006
Gavin MA, Torgerson TR, Houston E, DeRoos P, Ho WY, Stray-Pedersen A, Ocheltree EL, Greenberg PD, Ochs
HD, Rudensky AY: Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without
regulatory T cell development. PNAS. 103(17): 6659-64, 2006
Groh V, Br?l A, El-Gabalawy H, Nelson JL, Spies T: Stimulation of T cell autoreactivity by anomalous
expression of NKG2D and its MIC ligands in rheumatoid arthritis.
Proc Natl Acad Sci USA 100: 9452-9457, 2003
Hirst C, Buzza M, Bird C, Warren H, Cameron P, Zhang M, Ashton-Rickardt P, Bird P: The intracellular
granzyme B inhibitor, proteinase inhibitor 9, is up-regulated during accessory cell maturation and effector cell
degranulation, and its overexpression enhances CTL potency. J Immunol 170: 805-815, 2003
Hunger RE, Sieling PA, Ochoa MT, Sugaya M, Burdick AE, Rea TH, Brennan PJ, Belisle JT, Blauvelt A, Porcelli
SA, Modlin RL: Langerhans cells utilize CD1a and langerin to efficiently present nonpeptide antigens to T cells.
J Clin Invest 113(5): 701-708, 2004
LaBonte J, Madani N, Sodroski J: Cytolysis by CCR5-using human immunodeficiency virus type 1 envelope
glycoproteins is dependent on membrane fusion and can be inhibited by high levels of CD4 expression.
J Virol 77: 6645-6659, 2003
Leiba M, Cahalon L, Shimoni A, Lider O, Zanin-Zhorov A, Hecht I, Sela U, Vlodavsky I, Nagler A: Halofuginone
inhibits NF-kappaB and p38 MAPK in activated T cells. J Leukoc Biol. 80(2): 399-406, 2006
Rabin RL, Alston MA, Sircus JC, Knollmann-Ritschel B, Moratz C, Ngo D, Farber JM: CXCR3 is induced early on
the pathway of CD4+ T cell differentiation and bridges central and peripheral functions.
J Immunol 171: 2812-2824, 2003
Roose JP, Mollenauer M, Ho M, Kurosaki T, Weiss A: Unusual Interplay of Two Types of Ras Activators,
RasGRP and SOS, Establishes Sensitive and Robust Ras Activation in Lymphocytes.
Mol Cell Biol. 2007 (Epub ahead of print)
Sasaki H, Nishikata I, Shiraga T, Akamatsu E, Fukami T, Hidaka T, Kubuki Y, Okayama A, Hamada K, Okabe H,
Murakami Y, Tsubouchi H, Morishita K: Overexpression of a cell adhesion molecule, TSLC1, as a possible
molecular marker for acute-type adult T-cell leukemia. Blood 105(3), 1204-1213, 2005
Sato K, Niessner A, Kopecky SL, Frye RL, Goronzy JJ, Weyand CM: TRAIL-expressing T cells induce apoptosis
of vascular smooth muscle cells in the atherosclerotic plaque. J Exp Med. 203(1): 239-50, 2006
Swainson L, Verhoeyen E, Cosset FL, Taylor N: IL-7R alpha gene expression is inversely correlated with cell
cycle progression in IL-7-stimulated T lymphocytes. J Immunol. 176(11): 6702-8, 2006
Tay S, McCormack A, Lawson C, Rose M: IFN-g reverses the stop signal allowing migration of antigen-specific
T cells into inflammatory sites. J Immunol 170: 3315-3322, 2003
Tsang JY, Camara NO, Eren E, Schneider H, Rudd C, Lombardi G, Lechler R: Altered proximal T cell receptor
(TCR) signaling in human CD4+CD25+ regulatory T cells. J Leukoc Biol. 80(1): 145-51, 2006
Veler H, Hu A, Fatma S, Grunstein JS, Destephan CM, Campbell D, Orange JS, Grunstein MM: Superantigen
Presentation by Airway Smooth Muscle to CD4+ T Lymphocytes Elicits Reciprocal Proasthmatic Changes in
Airway Function. J Immunol. 178(6): 3627-36, 2007
Verhoeyen E, Dardalhon V, Ducrey-Rundquist O, Trono D, Taylor N, Cosset F: IL-7 surface-engineered
lentiviral vectors promote survival and efficient gene transfer in resting primary T lymphocytes.
Blood 101: 2167-2174, 2003
Wildum S, Schindler M, Munch J, Kirchhoff F: Contribution of Vpu, Env, and Nef to CD4 down-modulation and
resistance of human immunodeficiency virus type 1-infected T cells to superinfection.
J Virol. 80(16): 8047-59, 2006
Wright JF, Guo Y, Quazi A, Luxenberg DP, Bennett F, Ross JF, Qiu Y, Whitters MJ, Tomkinson KN, DunussiJoannopoulos K, Carreno BM, Collins M, Wolfman NM: Identification of an IL-17F/IL-17A heterodimer in
activated human CD4+ T cells. J Biol Chem. 2007 (Epub ahead of print)
Human CD4+CD25+ Cell Enrichment (15862)
Liyanage UK, Moore TT, Joo H-G, Tanaka Y, Herrmann V, Doherty G, Drebin JA, Strasberg SM, Eberlein TJ,
Goedegebuure PS, Linehan DC: Prevalence of regulatory T cells is increased in peripheral blood and tumor
microenvironment of patients with pancreas or breast adenocarcinoma. J Immunol 169: 2756-2761, 2002
Human CD8+ Cell Enrichment (15023, 15063)
Addo M, Yu X, Rathod A, Cohen D, Eldridge R, Strick D, Johnston M, Corcoran C, Wurcel A, Fitzpatrick C,
Feeney M, Rodriguez W, Basgoz N, Draenert R, Stone D, Brander C, Goulder P, Rosenberg E, Altfeld M, Walker
B: Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses
directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no
correlation to viral load. J Virol 77: 2081-2092, 2003
Dyugovskaya L, Lavie P, Lavie L: Phenotypic and functional characterization of blood gd T cells in sleep
apnea. Am J Respir Crit Care Med 168: 242-249, 2003
Hirst C, Buzza M, Bird C, Warren H, Cameron P, Zhang M, Ashton-Rickardt P, Bird P: The intracellular
granzyme B inhibitor, proteinase inhibitor 9, is up-regulated during accessory cell maturation and effector cell
degranulation, and its overexpression enhances CTL potency. J Immunol 170: 805-815, 2003
Leiba M, Cahalon L, Shimoni A, Lider O, Zanin-Zhorov A, Hecht I, Sela U, Vlodavsky I, Nagler A: Halofuginone
inhibits NF-kappaB and p38 MAPK in activated T cells. J Leukoc Biol. 80(2): 399-406, 2006
Mueller Y, Bojczuk P, Halstead E, Kim A, Witek J, Altman J, Katsikis P: IL-15 enhances survival and function of
HIV-specific CD8+ T cells. Blood 101: 1024-1029, 2003
Topp MS, Riddell SR, Akatsuka Y, Jensen MC, Blattman JN, Greenberg PD: Restoration of CD28 expression in
CD28- CD8+ memory effector T cells reconstitutes antigen-induced IL-2 production.
J Exp Med 198: 947-955, 2003
Xu T, Shu CT, Purdom E, Dang D, Ilsely D, Guo Y, Weber J, Holmes SP, Lee PP: Microarray analysis reveals
differences in gene expression of circulating CD8+ T cells in melanoma patients and healthy donors.
Cancer Res 64: 3661-3667, 2004
Human CD4+ & CD8+ Cell Enrichment (15022, 15023)
Frahm N, Korber BT, Adams CM, Szinger JJ, Draenert R, Addo MM, Feeney ME, Yusim K, Sango K, Brown NV,
SenGupta D, Piechocka-Trocha A, Simonis T, Marincola FM, Wurcel AG, Stone DR, Russell CJ, Adolf P, Cohen D,
Roach T, St. John A, Khatri A, Davis K, Mullins J, Goulder PJR, Walker BD, Brander C: Consistent cytotoxic-Tlymphocyte targeting of immunodominant regions in human immunodeficiency virus across multiple ethnicities.
J Virol 78(5): 2187- 2200, 2004
Human B Cell Enrichment (15024, 15064)
Asokan R, Hua J, Young KA, Gould HJ, Hannan JP, Kraus DM, Szakonyi G, Grundy GJ, Chen XS, Crow MK,
Holers VM: Characterization of human complement receptor type 2 (CR2/CD21) as a receptor for IFN-alpha: a
potential role in systemic lupus erythematosus. J Immunol. 177(1): 383-94, 2006
Barragan M, de Frias M, Iglesias-Serret D, Campas C, Castano E, Santidrian AF, Coll-Mulet L, Cosialls AM,
Domingo A, Pons G, Gil J: Regulation of Akt/PKB by phosphatidylinositol 3-kinase-dependent and independent pathways in B-cell chronic lymphocytic leukemia cells: role of protein kinase C{beta}
J Leukoc Biol. 2006 (Epub ahead of print)
B?iguel L, Diallo TO, Remou?F, Williams DL, Cognasse F, Charrier-Mze N, N'Diaye AA, Perraut R, Capron M,
Riveau G, Garraud O: Differential production in vitro of antigen specific IgG1, IgG3 and IgA: A
study in Schistosoma haematobium infected individuals. Parasite Immunol 25: 39-44, 2003
Chen G, Zhou L, Styblo M, Walton F, Jing Y, Weinberg R, Chen Z, Waxman S: Methylated metabolites of
arsenic trioxide are more potent than arsenic trioxide as apoptotic but not differentiation induces in leukemia
and lymphoma cells. Cancer Res 63: 1853-1859, 2003
Fu L, Lin-Lee YC, Pham LV, Tamayo A, Yoshimura L, Ford RJ: Constitutive NF-kappaB and NFAT activation
leads to stimulation of the BLyS survival pathway in aggressive B-cell lymphomas.
Blood. 107(11): 4540-8, 2006
Hirst C, Buzza M, Bird C, Warren H, Cameron P, Zhang M, Ashton-Rickardt P, Bird P: The intracellular
granzyme B inhibitor, proteinase inhibitor 9, is up-regulated during accessory cell maturation and effector cell
degranulation, and its overexpression enhances CTL potency. J Immunol 170: 805-815, 2003
Hornell TM, Burster T, Jahnsen FL, Pashine A, Ochoa MT, Harding JJ, Macaubas C, Lee AW, Modlin RL, Mellins
ED: Human dendritic cell expression of HLA-DO is subset specific and regulated by maturation.
J Immunol. 176(6): 3536-47, 2006
Ng Y-S, Wardemann H, Chelnis J, Cunningham-Rundles C, Meffre E: Bruton's Tyrosine Kinase Is Essential for
Human B Cell Tolerance. J Exp Med 200(7), 927-934, 2004
Precopio M, Sullivan J, Willard C, Somasundaran M, Luzuriaga K: Differential kinetics and specificity of EBVspecific CD4+ and CD8+ T cells during primary infection. J Immunol 170: 2590-2598, 2003
Starlets D, Gore Y, Binsky I, Haran M, Harpaz N, Shvidel L, Becker-Herman S, Berrebi A, Shachar I: Cellsurface CD74 initiates a signaling cascade leading to cell proliferation and survival.
Blood. 107(12): 4807-16, 2006
Weller S, Braun MC, Tan BK, Rosenwald A, Cordier C, Conley ME, Plebani A, Kumararatne DS, Bonnet D,
Tournilhac O, Tchemia G, Steiniger B, Staudt LM, Casanova, JL, Reynaud CA, Weill JC: Human blood IgM
뱈 emory?B cells are circulating splenic marginal zone B cells harboring a prediversified immunoglobulin
repertoire. Blood 104 (12) p 3647 2004
Zaninoni A, Imperiali FG, Pasquini C, Zanella A, Barcellini W: Cytokine modulation of nuclear factor-kB activity
in B-chronic lymphocytic leukemia. Exp Hematol 31: 185-190, 2003
Human NK Cell Enrichment (15025, 15065)
Castriconi R, Dondero A, Cantoni C, Della Chiesa M, Prato C, Nanni M, Fiorini M, Notarangelo L, Parolini S,
Moretta L, Notarangelo L, Moretta A, Bottino C: Functional characterization of natural killer cells in type I
leukocyte adhesion deficiency. Blood. 2007 (Epub ahead of print)
Cebo C, Da Rocha S, Wittnebel S, Turhan AG, Abdelali J, Caillat-Zucman S, Bourhis JH, Chouaib S, Caignard
A: The decreased susceptibility of Bcr/Abl targets to NK cell-mediated lysis in response to imatinib mesylate
involves modulation of NKG2D ligands, GM1 expression, and synapse formation.
J Immunol. 176(2): 864-72, 2006
Chan H, Kurago Z, Stewart CA, Wilson M, Martin M, Mace B, Carrington M, Trowsdale J, Lutz C: DNA
methylation maintains allele-specific KIR gene expression in human natural killer cells. J Exp Med 197: 245255, 2003
Chen X, Allan DS, Krzewski K, Ge B, Kopcow H, Strominger JL: CD28-stimulated ERK2 phosphorylation is
required for polarization of the microtubule organizing center and granules in YTS NK cells.
PNAS. 103(27): 10346-51, 2006
Della Chiesa M, Carlomagno S, Frumento G, Balsamo M, Cantoni C, Conte R, Moretta L, Moretta A, Vitale M:
The tryptophan catabolite L-kynurenine inhibits the surface expression of NKp46 and NKG2D activating
receptors and regulates NK cell function. Blood. 108(13): 4118-25, 2006
Fontana S, Parolini S, Vermi W, Booth S, Gallo F, Donini M, Benassi M, Gentili F, Ferrari D, Notarangelo LD,
Cavadini P, Marcenaro E, Dusi S, Cassatella M, Facchetti F, Griffiths GM, Moretta A, Notarangelo LD, Badolato
R: Innate immunity defects in Hermansky-Pudlak type 2 syndrome. Blood. 107(12):4857-64, 2006
Goda C, Kanaji T, Kanaji S, Tanaka G, Arima K, Ohno S, Izuhara K: Involvement of IL-32 in activationinduced cell death in T cells. Int Immunol. 18(2):233-40, 2006
Goodridge JP, Witt CS, Christiansen FT, Warren HS: KIR2DL4 (CD158d) genotype influences expression and
function in NK cells. J Immunol 171: 1768-1774, 2003
He X, Draghi M, Mahmood K, Holmes TH, Kemble GW, Dekker CL, Arvin AM, Parham P, Greenberg HB: T celldependent production of IFN-γ by NK cells in response to influenza A virus. J Clin Invest 114, 1812-1819, 2004
Hirst C, Buzza M, Bird C, Warren H, Cameron P, Zhang M, Ashton-Rickardt P, Bird P: The intracellular
granzyme B inhibitor, proteinase inhibitor 9, is up-regulated during accessory cell maturation and effector cell
degranulation, and its overexpression enhances CTL potency. J Immunol 170: 805-815, 2003
Keskin DB, Allan DSJ, Rybalov B, Andzelm MM, Stern JNH, Kopcow HD, Koopman LA, Strominger JL: TGF
promotes conversion of CD16+ peripheral blood NK cells into CD16?NK cells with similarities to decidual NK
cells. PNAS. 104: 3378-3383, 2007
Miyagawa S, Kubo T, Matsunami K, Kusama T, Beppu K, Nozaki H, Moritan T, Ahn C, Kim JY, Fukuta D,
Shirakura R: Delta-Short Consensus Repeat 4-Decay Accelerating Factor (DAF: CD55) Inhibits Complement-
Mediated Cytolysis but Not NK Cell-Mediated Cytolysis. J Immunol 173(6), 3945-3952, 2004
Poggi A, Massaro A-M, Negrini S, Contini P, Raffaella Zocchi M: Tumor-induced apoptosis of human IL-2activated NK cell: Role of natural cytotoxicity receptors. J Immunol 174: 2653-2660, 2005
Ruggeri L, Mancusi A, Capanni M, Urbani E, Carotti A, Aloisi T, Stern M, Pende D, Perruccio K, Burchielli E,
Topini F, Bianchi E, Aversa F, Martelli MF, Velardi A: Donor natural killer cell allorecognition of missing self in
haploidentical hematopoietic transplantation for acute myeloid leukemia: challenging its predictive
value. Blood. 2007 (Epub ahead of print)
Roda JM, Parihar R, Lehman A, Mani A, Tridandapani S, Carson WE 3rd: Interleukin-21 enhances NK cell
activation in response to antibody-coated targets. J Immunol. 177(1): 120-9, 2006
Stefania Marcenaro, Federico Gallo, Stefania Martini, Alessandra Santoro, Gillian M. Griffiths, Maurizio Aric?
Lorenzo Moretta, and Daniela Pende: Analysis of natural killer 뻙 ell function in familial hemophagocytic
lymphohistiocytosis (FHL): defective CD107a surface expression heralds Munc13-4 defect and discriminates
between genetic subtypes of the disease. Blood. 108(7): 2316-2323, 2006
Vacca P, Pietra G, Falco M, Romeo E, Bottino C, Bellora F, Prefumo F, Fulcheri E, Venturini PL, Costa M,
Moretta A, Moretta L, Mingari MC: Analysis of Natural Killer cells isolated from human decidua: evidence that
2B4 (CD244) functions as an inhibitory receptor and blocks NK cell function. Blood. 108(13): 4078-85, 2006
Human Total Lymphocyte Enrichment (15223/15263)
Hotchkiss RS, McConnell KW, Bullok K, Davis CG, Chang KC, Schwulst SJ, Dunne JC, Dietz GP, Bahr M,
McDunn JE, Karl IE, Wagner TH, Cobb JP, Coopersmith CM, Piwnica-Worms D: TAT-BH4 and TAT-Bcl-xL
peptides protect against sepsis-induced lymphocyte apoptosis in vivo. J Immunol. 176(9): 5471-7, 2006
Human Monocyte Enrichment (15028, 15068)
Carmona EM, Vassallo R, Vuk-Pavlovic Z, Standing JE, Kottom TJ, Limper AH: Pneumocystis cell wall betaglucans induce dendritic cell costimulatory molecule expression and inflammatory activation through a Fas-Fas
ligand mechanism. J Immunol. 177(1): 459-67, 2006
Ebstein F, Sapede C, Royer PJ, Marcq M, Ligeza-Poisson C, Barbieux I, Cellerin L, Dabouis G, Gregoire M:
Cytotoxic T cell responses against mesothelioma by apoptotic cell-pulsed dendritic cells. Am J Respir Crit Care
Med 169(12):1322-30, 2004
Fulcher JA, Hashimi ST, Levroney EL, Pang M, Gurney KB, Baum LG, Lee B: Galectin-1-matured human
monocyte-derived dendritic cells have enhanced migration through extracellular matrix.
J Immunol. 177(1): 216-26, 2006
Gamache-Ottou F, Chaperot L, Biichle S, Ferrand C, Remy-Martin J-P, Deconinck E, Darodes de Tailly P,
Bulabois B, Poulet J, Kuhlein E, Jacob M-C, Salaun V, Arock M, Drenou B, Schillinger F, Seilles E, Tiberghien P,
Bensa J-C, Plumas J, Saas P: Expression of the myeloid-associated marker CD33 is not an exclusive factor for
leukemic plasmacytoid dendritic cells. Blood 105(3): 1256-1264, 2005
Hirst C, Buzza M, Bird C, Warren H, Cameron P, Zhang M, Ashton-Rickardt P, Bird P: The intracellular
granzyme B inhibitor, proteinase inhibitor 9, is up-regulated during accessory cell maturation and effector cell
degranulation, and its overexpression enhances CTL potency. J Immunol 170: 805-815, 2003
Kohler JJ, Tuttle DL, Coberley CR, Sleasman JW, Goodenow MM: Human immunodeficiency virus type 1 (HIV1) induces activation of multiple STATs in CD4+ cells of lymphocyte or monocyte/macrophage lineages. J
Leukoc Biol. 73(3): 407-416, 2003
Korpi-Steiner NL, Bates ME, Lee WM, Hall DJ, Bertics PJ: Human rhinovirus induces robust IP-10 release by
monocytic cells, which is independent of viral replication but linked to type I interferon receptor ligation and
STAT1 activation. J Leukoc Biol. 80(6): 1364-74, 2006
Laudanski K, Miller-Graziano C, Xiao W, Mindrinos MN, Richards DR, De A, Moldawer LL, Maier RV, Bankey P,
Baker HV, Brownstein BH, Cobb JP, Calvano SE, Davis RW, Tompkins RG: Cell-specific expression and pathway
analyses reveal alterations in trauma-related human T cell and monocyte pathways.
PNAS. 103(42): 15564-9, 2006
Li J, Pritchard DK, Wang X, Park DR, Bumgarner R, Schwartz SM, Liles WC: cDNA microarray analysis reveals
fundamental differences in the expression profiles of primary human monocytes, monocyte-derived
macrophages, and alveolar macrophages. J Leukoc Biol. 2006 (Epub ahead of print)
Ranga U, Shankarappa R, Siddappa NB, Ramakrishna L, Nagendran R, Mahalingam M, Mahadevan A,
Jayasuryan N, Satishchandra P, Shankar SK, Prasad VR: Tat protein of human immunodeficiency virus type 1
subtype C strains is a defective chemokines. J Virol 78(5): 2586-2590, 2004
Rouhiainen A, Kuja-Panula J, Wilkman E, Pakkanen J, Stenfors J, Ruominen RK, Lepantalo M, Carpen O,
Parkkinen J, Rauvala H: Regulation of monocyte migration by amphoterin (HMGB1).
Blood 104(4): 1174-1182, 2004
Sieling PA, Chung W, Duong BT, Godowski PJ, Modlin RL: Toll-like receptor 2 ligands as adjuvants for human
Th1 responses. J Immunol 170: 194-200, 2003
Tsuboi S: A complex of Wiskott-Aldrich syndrome protein with mammalian verprolins plays an important role
in monocyte chemotaxis. J Immunol. 176(11): 6576-85, 2006
Wada Y, Lu R, Zhou D, Chu J, Przewloka T, Zhang S, Li L, Wu Y, Qin J, Balasubramanyam V, Barsoum J, Ono
M: Selective abrogation of Th1 response by STA-5326, a potent IL-12/IL-23 inhibitor.
Blood. 2006 (Epub ahead of print)
Wellington M, Bliss JM, Haidaris CG: Enhanced phagocytosis of Candida species mediated by opsonization with
a recombinant human antibody single-chain variable fragment. Infect and Immunity 71(12) p7228 2004
Human Monocyte & T Cell Enrichment (15028, 15021)
Cobb JP, Mindrinos MN, Ciller-Graziano C, Calvano SE, Baker HV, Xiao W, Laudanski K, Brownstein BH, Elson
CM, Hayden DL, Herndon DN, Lowry SF, Maier RV, Schoenfeld DA, Moldawer LL, Davis RW, Tomkins RG:
Application of genome-wide expression analysis to human health and disease.
Proc Nat Aca Sci 102(13): 4801-4806, 2005
Human Cord Blood Progenitor Cell Enrichment (15026, 15066)
Bischoff F, Marqu?-Do D, Martinez D, Dang D, Horne C, Lewis D, Simpson J: Intact fetal cell isolation from
maternal blood: improved isolation using a simple whole blood progenitor cell enrichment approach
(RosetteSep). Clin Genet 63: 483-489, 2003
Frelin C, Imbert V, Griessinger E, Peyron AC, Rochet N, Philip P, Dageville C, Sirvent A, Hummelsberger M,
B?ard E, Dreano M, Sirvent N, Peyron JF: Targeting NF-KB activation via pharmacologic inhibition of IKK2induced apoptosis of human acute myeloid leukemia cells. Blood 105 (2), 804-811, 2005
Hunger RE, Sieling PA, Ochoa MT, Sugaya M, Burdick AE, Rea TH, Brennan PJ, Belisle JT, Blauvelt A, Porcelli
SA, Modlin RL: Langerhans cells utilize CD1a and langerin to efficiently present nonpeptide antigens to T cells.
J Clin Invest 113(5): 701-708, 2004
Mitchell WB, Li J, Murcia M, Valentin N, Newman PJ, Coller BS: Mapping early conformational changes in
{alpha}IIb and {beta}3 during biogenesis reveals a potential mechanism for {alpha}IIb{beta}3 adopting its
bent conformation. Blood. 2007 (Epub ahead of print)
Renn CN, Sanchez DJ, Ochoa MT, Legaspi AJ, Oh CK, Liu PT, Krutzik SR, Sieling PA, Cheng G, Modlin RL: TLR
activation of Langerhans cell-like dendritic cells triggers an antiviral immune response.
J Immunol. 177(1): 298-305, 2006
Human Circulating Epithelial Tumor Cell Enrichment (15127, 15167)
Castriconi R, Dondero A, Augugliaro R, Cantoni C, Carnemolla B, Sementa AR, Negri F, Conte R, Corrias MV,
Moretta L, Moretta A, Bottino C: Identification of 4Ig-B7-H3 as a neuroblastoma-associated molecule that
exerts a protective role from an NK cell-mediated lysis. Proc Nat Aca Sci 101(34): 12640-12645, 2004
Human Mesenchymal Stem Cells (15128, 15168)
Lee JH, Kosinski PA, Kemp DM: Contribution of human bone marrow stem cells to individual skeletal myotubes
followed by myogenic gene activation. Exp Cell Res. 307(1):174-82, 2005
Lee OK, Kuo TK, Chen W-M, Lee K-D, Hsieh S-L, Chen T-H: Isolation of multipotent mesenchymal stem cells
from umbilical cord blood. Blood 103(5): 1669-1675, 2004
Merino A, Mazzara R, Fust?B, Diaz-Ricart M, Rozman M, Lozano M, Ordinas A: The mesenchymal stem cell
revealed. Transfusion 43: 1, 2003
Parsons CH, Szomju B, Kedes DH: Susceptibility of human fetal mesenchymal stem cells to Kaposi 뭩 sarcomaassociated herpesvirus. Blood 104(9): 2736-2738, 2004
Shih YR, Chen CN, Tsai SW, Wang YJ, Lee OK: Growth of mesenchymal stem cells on electrospun type I
collagen nanofibers. Stem Cells. 24(11): 2391-7, 2006
Human Multiple Myeloma Cell Enrichment (15129, 15169)
Hideshima T, Catley L, Yasui H, Ishitsuka K, Raje N, Mitsiades C, Podar K, Munshi NC, Chauhan D, Richardson
PG, Anderson KC: Perifosine, an oral bioactive novel alkylphospholipid, inhibits Akt and induces in vitro and in
vivo cytotoxicity in human multiple myeloma cells.
Blood. 107(10): 4053-62, 2006
Hideshima T, Chauhan D, Hayashi T, Podar K, Akiyama M, Mitsiades C, Mitsiades N, Gong B, Bonham L,
deVries P, Munshi N, Richardson PG, Singer JW, Anderson KC: Antitumor activity of lysophophatidic acid
acyltransferase-B inhibitors, a novel class of agents, in multiple myeloma.
Cancer Research 63: 8428-8436, 2003
Hideshima T, Mitsiades C, Akiyama M, Hayashi T, Chauhan D, Richardson P, Schlossman R, Podar K, Munshi
NC, Mitsiades N, Anderson KC: Molecular mechanisms mediating antimyeloma activity of proteasome inhibitor
PS-341. Blood 101: 1530-1534, 2003
Podar K, Tai Y-T, Cole C, Hideshima T, Sattler M, Hamblin A, Mitsiades N, Schlossman R, Davies F, Morgan G,
Munshi N, Chauhan D, Anderson KC: Essential role of caveolae in interleukin-6 and insulin-like growth factor Itriggered Akt-1-mediated survival of multiple myeloma cells. J Biol Chem 278: 5794-5801, 2003
Human CD3+ Depletion (15621, 15661)
He X, Draghi M, Mahmood K, Holmes TH, Kemble GW, Dekker CL, Arvin AM, Parham P, Greenberg HB: T celldependent production of IFN-γ by NK cells in response to influenza A virus. J Clin Invest 114, 1812-1819, 2004
Lichterfeld M, Kaufmann DE, Yu XG, Mui SK, Addo MM, Johnston MN, Cohen D, Robbins GK, Pae E, Alter G,
Wurcel A, Stone D, Rosenberg ES, Walker BD, Altfeld M: Loss of HIV-1-specific CD8+ T cell proliferation after
acute HIV-1 infection and restoration by vaccine-induced HIV-1-specific CD4+ T cells.
J Exp Med 200(6) p701 2004
Liu W, Putnam AL, Xu-Yu Z, Szot GL, Lee MR, Zhu S, Gottlieb PA, Kapranov P, Gingeras TR, Fazekas de St
Groth B, Clayberger C, Soper DM, Ziegler SF, Bluestone JA: CD127 expression inversely correlates with FoxP3
and suppressive function of human CD4+ T reg cells. J Exp Med. 203(7): 1701-11, 2006
Human CD4+ Depletion (15622, 15662)
Hunger RE, Sieling PA, Ochoa MT, Sugaya M, Burdick AE, Rea TH, Brennan PJ, Belisle JT, Blauvelt A, Porcelli
SA, Modlin RL: Langerhans cells utilize CD1a and langerin to efficiently present nonpeptide antigens to T cells.
J Clin Invest 113(5): 701-708, 2004
Liu W, Putnam AL, Xu-Yu Z, Szot GL, Lee MR, Zhu S, Gottlieb PA, Kapranov P, Gingeras TR, Fazekas de St
Groth B, Clayberger C, Soper DM, Ziegler SF, Bluestone JA: CD127 expression inversely correlates with FoxP3
and suppressive function of human CD4+ T reg cells. J Exp Med. 203(7): 1701-11, 2006
von Bergwelt-Baildon MS, Popov A, Saric T, Chemnitz J, Classen S, Stoffel MS, Fiore F, Roth U, Beyer M, Debey
S, Wickenhauser C, Hanisch FG, Schultze JL: CD25 and indoleamine 2,3-dioxygenase are up-regulated by
prostaglandin E2 and expressed by tumor-associated dendritic cells in vivo: additional mechanisms of T-cell
inhibition. Blood. 108(1): 228-37, 2006
Human Lymphoid (CD3+) & Myeloid (CD33+) Kits (15271, 15272)
Bishop MR, Steinberg SM, Gress RE, Hardy NM, Marchigiani D, Kasten-Sportes C, Dean R, Pavletic SZ, GeaBanacloche J, Castro K, Hakim F, Krumlauf M, Read EJ, Carter C, Leitman SF, Fowler DH: Targeted
pretransplant host lymphocyte depletion prior to T-cell depleted reduced-intesnity allogeneic stem cell
transplantation. Brit J Haematology 126: 837-843, 2004
Ueno NT, Cheng YC, Rond? G, Tannir NM, Gajewski JL, Couriel DR, Hosing C, de Lima MJ, Anderlini P, Khouri IF,
Booser DJ, Hortobagyi GN, Pagliaro LC, Jonasch E, Giralt SA, Champlin RE: Rapid induction of complete donor
chimerism by the use of a reduced-intensity conditioning regimen composed of fludarabine and melphalan in
allogeneic stem cell transplantation for metastatic solid tumors. Blood 102 (10): 3829-3836, 2003
Human Lymphoid (CD3+) & B Cell Kit (15271, 15024)
Vasir B, Avigan D, Wu Z, Crawford K, Turnquist S, Ren J, Kufe D: Dendritic cells induce MUC1 expression and
polariation on human T cells by an IL-7 dependent mechanism. J Immunol 174, 2376-2386, 2005
Custom Cocktail
Naume B, Borgen E, T?svik S, Pavlak N, Oates D, Nesland JM: Detection of isolated tumor cells in peripheral
blood and in BM: evaluation of a new enrichment method. Cytotherapy 6(3) p 244, 2004
Vuillier F, Dumas G, Magnac C, Prevost MC, Lalanne AI, Oppezzo P, Melanitou E, Dighiero G, Pavelle-Brogard
B: Lower levels of surface B-cell-receptor expression in chronic lymphocytic leukaemia are associated with
glycosylation and folding defects of the mu and CD79a chains. Blood 105(7): 2933-2940, 2005