Supplemental reference list for BCL6 target genes.
Target gene
ISGF3, STAT2, CXCR4, p27KIP1, EBI2, IP10, CD69,CD44,
9-27(IFITM1), ID2, 1-8U (IFITM3),MIP1α, STAT1, CYCLIND2
BLIMP1
P53
IL18
NFκBI
ATR
P21*
CD80
STAT3
BCLxL(BCL2L1)
References#
8
8, 2
4
1
6
7
5*
3
Personnel communication
( Hilda Ye)
9
* Indirect target
1.
2.
3.
4.
5.
6.
7.
8.
9.
Takeda, N., Arima, M., Tsuruoka, N., Okada, S., Hatano, M., Sakamoto, A., Kohno, Y., and
Tokuhisa, T. Bcl6 is a transcriptional repressor for the IL-18 gene. J Immunol, 171: 426-431, 2003.
Tunyaplin, C., Shaffer, A. L., Angelin-Duclos, C. D., Yu, X., Staudt, L. M., and Calame, K. L. Direct
repression of prdm1 by Bcl-6 inhibits plasmacytic differentiation. J Immunol, 173: 1158-1165, 2004.
Niu, H., Cattoretti, G., and Dalla-Favera, R. BCL6 controls the expression of the B7-1/CD80
costimulatory receptor in germinal center B cells. J Exp Med, 198: 211-221, 2003.
Phan, R. T. and Dalla-Favera, R. The BCL6 proto-oncogene suppresses p53 expression in germinalcentre B cells. Nature, 432: 635-639, 2004.
Phan, R. T., Saito, M., Basso, K., Niu, H., and Dalla-Favera, R. BCL6 interacts with the transcription
factor Miz-1 to suppress the cyclin-dependent kinase inhibitor p21 and cell cycle arrest in germinal
center B cells. Nat Immunol, 6: 1054-1060, 2005.
Li, Z., Wang, X., Yu, R. Y., Ding, B. B., Yu, J. J., Dai, X. M., Naganuma, A., Stanley, E. R., and Ye,
B. H. BCL-6 negatively regulates expression of the NF-kappaB1 p105/p50 subunit. J Immunol, 174:
205-214, 2005.
Stella M. Ranuncolo, Jose M. Polo, Jamil Dierov, Rita Shaknovich, Martin Carroll, and Melnick, A.
M. BCL6 Attenuates DNA Damage Sensing in Normal and Malignant B-Cells by Directly
Repressing ATR. [Abstract#157]. Blood, 106, 2005.
Shaffer, A. L., Yu, X., He, Y., Boldrick, J., Chan, E. P., and Staudt, L. M. BCL-6 represses genes that
function in lymphocyte differentiation, inflammation, and cell cycle control. Immunity, 13: 199-212,
2000.
Tang, T. T., Dowbenko, D., Jackson, A., Toney, L., Lewin, D. A., Dent, A. L., and Lasky, L. A. The
forkhead transcription factor AFX activates apoptosis by induction of the BCL-6 transcriptional
repressor. J Biol Chem, 277: 14255-14265, 2002.
References for NF-kB target list
Target gene Reference#
IP10
(1),
BCLxL
(2-3)
P21
(4)
CD80
(5-6)
MIPa
(7)
CD44
(8)
Complete list
(9)
1.
2.
3.
4.
5.
6.
7.
8.
9.
Ohmori, Y. and Hamilton, T. A. Cooperative interaction between interferon (IFN) stimulus response
element and kappa B sequence motifs controls IFN gamma- and lipopolysaccharide-stimulated
transcription from the murine IP-10 promoter. J Biol Chem, 268: 6677-6688, 1993.
Lee, H. H., Dadgostar, H., Cheng, Q., Shu, J., and Cheng, G. NF-kappaB-mediated up-regulation of
Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes. Proc Natl Acad Sci U
S A, 96: 9136-9141, 1999.
Chen, F., Demers, L. M., Vallyathan, V., Lu, Y., Castranova, V., and Shi, X. Involvement of 5'flanking kappaB-like sites within bcl-x gene in silica-induced Bcl-x expression. J Biol Chem, 274:
35591-35595, 1999.
Hinata, K., Gervin, A. M., Jennifer Zhang, Y., and Khavari, P. A. Divergent gene regulation and
growth effects by NF-kappa B in epithelial and mesenchymal cells of human skin. Oncogene, 22:
1955-1964, 2003.
Fong, T. C., Wu, Y., and Kipps, T. J. Identification of a promoter element that regulates tissuespecific expression of the human CD80 (B7.1) gene. J Immunol, 157: 4442-4450, 1996.
Zhao, J., Freeman, G. J., Gray, G. S., Nadler, L. M., and Glimcher, L. H. A cell type-specific
enhancer in the human B7.1 gene regulated by NF-kappaB. J Exp Med, 183: 777-789, 1996.
Grove, M. and Plumb, M. C/EBP, NF-kappa B, and c-Ets family members and transcriptional
regulation of the cell-specific and inducible macrophage inflammatory protein 1 alpha immediateearly gene. Mol Cell Biol, 13: 5276-5289, 1993.
Hinz, M., Lemke, P., Anagnostopoulos, I., Hacker, C., Krappmann, D., Mathas, S., Dorken, B.,
Zenke, M., Stein, H., and Scheidereit, C. Nuclear factor kappaB-dependent gene expression profiling
of Hodgkin's disease tumor cells, pathogenetic significance, and link to constitutive signal transducer
and activator of transcription 5a activity. J Exp Med, 196: 605-617, 2002.
Feuerhake, F., Kutok, J. L., Monti, S., Chen, W., LaCasce, A. S., Cattoretti, G., Kurtin, P., Pinkus, G.
S., de Leval, L., Harris, N. L., Savage, K. J., Neuberg, D., Habermann, T. M., Dalla-Favera, R.,
Golub, T. R., Aster, J. C., and Shipp, M. A. NFkappaB activity, function, and target-gene signatures
in primary mediastinal large B-cell lymphoma and diffuse large B-cell lymphoma subtypes. Blood,
106: 1392-1399, 2005.