Class: Name: 11 ( ) Date: Cell cycle and division 11.1 Chromosomes (Book 2, p. 11-5) The genetic information of an organism is carried in (1) _______________ (deoxyribonucleic acid) which is present in the (2) _______________ of a cell. A DNA molecule coils around some special proteins to form a (3) _______________. one chromosome (染色體) DNA molecule coils into a highly organized pattern special protein chromatids (染色單體) centromere (着絲點) DNA molecule A chromosome just before cell division (×9000) Structure of a chromosome Term I chromosome II chromatin (染色質) III chromatid IV centromere Explanation a the appearance of chromosome when the cell is not dividing. It is very thin and cannot be seen clearly under microscope b a point at which a pair of chromatids joins c a structure found in the nucleus, which is made up of a DNA molecule coiling up around proteins d I: (4) ___________ each of the two daughter strands of a duplicated chromosome II: (5) ___________ III: (6) ___________ IV: (7) __________ Chromosomes exist in (8) _______________ in the body cells. Members of each pair of chromosomes are called (9) _______________ chromosomes. New Senior Secondary Mastering Biology Oxford University Press 2009 1 A cell with two sets of chromosomes is a (10) _______________ (2n) (二倍體) cell. It is produced by (11) _______________ cell division (有絲細胞分裂). A cell with only one set of chromosomes is a (12) _______________ (n) (單倍體) cell. It is produced by (13) _______________ cell division (減數細胞分裂). Humans have (14) _______________ pairs or (15) _______________ chromosomes. The 23rd pair is the (16) _______________ chromosomes. Go to … Quick check (Book 2, p. 11-7) 11.2 Chromosomes (Book 2, p. 11-8) From one cell division to the next, a cell undergoes a sequence of events known as the (1) _______________ _______________ (細胞週期). A What are the main stages of the cell cycle? (Book 2, p. 11-8) first growth phase (G1) cytoplasmic division (2) _______________ _______________ synthesis phase (S) second growth phase (G2) nuclear division (3) _______________ _______________ The cell cycle In each cell cycle, the cell spends most time on (4) _______________ _______________. The (5) _______________ of the cell cycle varies with different types of cells. B What happens to the cell in different stages of the cell cycle? (Book 2, p. 11-8) 1 Cell growth (Book 2, p. 11-9) Cell growth is also called (6) _______________ (間期). nuclear membrane During cell growth, chromosomes appear as a mass of thin threads called chromatin, many biochemical activities are taking place to prepare for (7) _______________. 2 chromatin (DNA replicated) DNA molecules replicated before division New Senior Secondary Mastering Biology Oxford University Press 2009 Phase Event First growth phase (G1) New (8) _______________ and proteins are made. Synthesis phase (S) (9) ______________ ______________ are replicated. Second growth phase (G2) Energy stores increase. The cell grows to its maximum size. 2 Mitotic cell division Mitotic cell division starts with (10) _______________ division followed by (Book 2, p. 11-9) (11) _______________ division. i) Nuclear division (12) _______________ (有絲分裂) is the nuclear division in mitotic cell division. During mitosis, the duplicate set of chromosomes is separated from the original set. Each new nucleus receives (13) _______________ complete set of chromosomes so that two identical (14) _______________ nuclei are formed. Mitosis consists of four main stages: chromosome Stage 1 (15)_______________ (前期) Chromosomes become visible. Each is seen to consist of two chromatids held together at the two identical chromatids centromere. The nuclear membrane (16) _______________. Stage 2 (17) _______________ (中期) The chromosomes line up in the (18) _______________ of the cell. Stage 3 (19) _______________ (後期) The (20) _______________ of each chromosome separate and move to the opposite poles of the cell. The cytoplasm starts to divide. Stage 4 (21) _______________ (末期) New (22) _______________ _______________ form around each set of chromosomes. New Senior Secondary Mastering Biology Oxford University Press 2009 The chromosomes uncoil to become chromatin again. 3 Misconception Some students wrongly think that chromosomes replicate at prophase when they become visible as thread-like structures. In fact, chromosomes replicate before cell division. They then shorten and become visible at prophase. ii) Cytoplasmic division Cytoplasmic division is also called (23) _______________ (胞質分裂). The cytoplasm of the parent cell divides into two equal halves to form two cells. Animal cells C Plant cells Cell membrane constricts Cell plate (細胞板) formed between the two (24) _______________. new nuclei grows (25) _______________. What is the significance of mitotic cell division? (Book 2, p. 11-12) Mitotic cell division is important for: (26) ____________: it provides new cells for the growth of multicellular organisms. repair: it provides new cells for replacing worn-out or damaged cells. (27) ____________ reproduction (無性生殖): it occurs in some organisms to produce offspring. Go to … Practical 11.1 Examination of different stages of the cell cycle (Book 2, p. 11-13; Practical Workbook for SBA 2, p. 11-1) Practical 11.2 Investigation of the relative time required for each stage of the cell cycle (Book 2, p. 11-13; Practical Workbook for SBA 2, p. 11-4) Quick check 4 (Book 2, p. 11-14) New Senior Secondary Mastering Biology Oxford University Press 2009 11.3 Meiotic cell division (Book 2, p. 11-15) A How does meiotic cell division occur? (Book 2, p. 11-15) Meiotic cell division reduces the (1) _______________ number by half and gives rise to (2) _______________ haploid daughter cells which are genetically (3) ______________. Meiotic cell division starts with nuclear division called (4) ______________ (減數分裂) followed by cytoplasmic division. It consists of first meiotic division and second meiotic division. First meiotic division a pair of homologous chromosome Stage 1 prophase I Chromosomes become visible. Members of each pair of (5) _______________ chromosomes pair up. The (6) _______________ membrane disintegrates. two chromatids Stage 2 metaphase I (7) _______________ _______________ line up in the middle of the cell. Stage 3 anaphase I The two members of each (8) _______________ _______________ separate and move to opposite poles of the cell. The cytoplasm starts to divide. Stage 4 telophase I New nuclear membranes form around each set of chromosomes. New Senior Secondary Mastering Biology Oxford University Press 2009 5 Second meiotic division Stage 5 prophase II Nuclear membranes disintegrate again. Stage 6 metaphase II (9) _______________ line up in the middle of the cells. Stage 7 anaphase II (10) _______________ separate and move to opposite poles of the cells. The cytoplasm starts to divide. Stage 8 telophase II New nuclear membranes form around each set of chromosomes. After (11) ______________ ______________ has completed, four (12) ______________ cells are formed. Each cell has one member of each homologous pair. Chromosomes uncoil to become chromatin again. Go to … Practical 11.3 Examination of meiotic cell division (Book 2, p. 11-15; Practical Workbook for SBA 2, p. 11-10) 6 New Senior Secondary Mastering Biology Oxford University Press 2009 B 1 What is the significance of meiotic cell division? (Book 2, p. 11-18) Meiosis produces haploid gametes (配子) for (13) _______________ reproduction (有性生殖), so that the diploid number of chromosome can be restored (還原) at fertilization. Two haploid gametes combine to form a diploid zygote 2 The random distribution and (14) _______________ _______________ (獨立分配) of chromosomes produce various genetic combinations in the gametes. The zygotes formed will have different genetic combinations from their parents. This causes genetic variation among individuals of the same species. Independent assortment of chromosomes in meiotic cell division New Senior Secondary Mastering Biology Oxford University Press 2009 7 Go to … Quick check (Book 2, p. 11-20) 11.4 Comparison between mitotic and meiotic cell divisions (Book 2, p. 11-21) Mitotic cell division Meiotic cell division Number of cell division (1) ______________ (2) ______________ Daughter cell Number produced (3) ______________ (4) ______________ Chromosome number (5) ______________ (2n) (6) ______________ (n) Genetic material (7) ______________ (8) ______________ ______________ parent cell ______________ parent cell and among daughter cells and among daughter cells (9) ___________ ___________ (10) ______________ Behaviour of chromosomes Pairing of homologous Pairing of homologous chromosomes does not occur chromosomes occurs Place of occurrence Body cells Gamete-producing cells in Cell type sex organ Significance Form cells for growth, Form haploid gametes for (11) ______________ and (13) ______________ (12) ______________ reproduction; reproduction provide (14) ______________ variations that enhance the survival of the species Go to … Quick check 8 (Book 2, p. 11-22) New Senior Secondary Mastering Biology Oxford University Press 2009 Exercise a The diagram below shows the relative time spent by the two main stages of the cell cycle. Y X i Name stages X and Y. (2 marks) ________________________________________________________________________ ii List three biochemical activities occur during stage X. (3 marks) ________________________________________________________________________ b The drawings below show two nuclei from the root tip cell of two different plant species during prophase of stage Y. species Q species P i In the nucleus of species P, one member of a pair of homologous chromosomes has been shaded. Shade the other member of the pair. ii State the number of chromosomes in the following cells: (1 mark) (2 marks) diploid cell of species P: ___________________ haploid cell of species Q: ___________________ iii Name the phase that occurs immediately after prophase. Describe the behaviour of chromosomes in this phase. (2 marks) ________________________________________________________________________ ________________________________________________________________________ Total: 10 marks - END - New Senior Secondary Mastering Biology Oxford University Press 2009 9 Answers Ch 11 Cell cycle and division 11.1 1 DNA 2 nucleus 3 chromosome 4 c 5 a 6 d 7 b 8 pairs 9 homologous 10 diploid 11 mitotic 12 haploid 13 meiotic 14 23 15 46 16 sex 3 mitotic cell division 11.2 1 cell cycle 2 cell growth/interphase 4 cell growth 5 duration 6 interphase 7 division 8 organelles 9 DNA molecules 10 nuclear 11 cytoplasmic 12 Mitosis 13 one 14 diploid 15 prophase 16 disintegrates 17 metaphase 18 middle 19 anaphase 20 chromatids 21 telophase 22 nuclear membrane 23 24 inwards 25 outwards 26 growth 27 asexual 1 chromosome 2 four 3 different 4 meiosis 5 homologous 6 nuclear 7 homologous pairs 8 homologous pair 9 Chromosomes 10 Chromatids 11 cytoplasmic division 12 haploid 13 sexual 14 independent assortment cytokinesis 11.3 11.4 1 1 2 2 3 2 4 4 5 diploid 6 haploid 7 same as 8 different from 9 body cell 10 gamete 11 repair 12 asexual 13 sexual 14 genetic Exercise a b i X: cell growth / interphase; Y: Mitotic cell division 2m ii DNA replication 1m protein synthesis 1m organelles synthesis 1m 1m i ii nucleus P: 6; nucleus Q: 6 2m iii Metaphase 1m Chromosomes line up in the middle of the cell. 1m 10 New Senior Secondary Mastering Biology Oxford University Press 2009