UCI
Incident Pre-Plan:
Biohazard Incident
Number:
A-3
Revision No.
1
Effective Date:
09/15/04
Section 1.0 - Purpose
1.1 This incident pre-plan provides guidance in the event of a biohazard incident which includes but is not limited to biohazardous materials spills, response to a potential bioterrorist event, or release of an infectious agent.
Section 2.0 - Applicability/Scope
2.1 This plan applies to all UCI owned and operated entities as defined in the Emergency
Management Plan.
2.2 This plan will be implemented based on the decision of the Emergency Response
Team (ERT) On-Scene Incident Commander and will provide guidance to the ERT,
Emergency Operations Center (EOC) Team and the Chancellor’s Executive Policy
Group (CEPG).
2.3 All minor biohazard spills and releases will be managed by the ERT using the UCI
EH&S Emergency Response Team Response Plan (Red Book).
Section 3.0 – References


UCI Policy# 90340 “Emergency Management” ( www.policies.uci.edu
)
UCI EH&S Emergency Response Team Response Plan


UCI Biosafety Handbook
Centers for Disease Control and Prevention (CDC) Biosafety in Microbiological and

Biomedical Laboratories (BMBL)
 http://www.cdc.gov/od/ohs/biosfty/bmbl4/bmbl4toc.htm
CDC Public Health Emergency Preparedness & Response
 http://www.bt.cdc.gov/
 Health Canada Material Safety Data Sheets for Infectious Agents
 http://www.ch-sc.gc.ca/pphp-dgspsp/msds-ftss/index.html
Originator
Approved by
Signature
S. Weekly
M. A. Gomez
Biosafety Officer
EH&S Director
Title Date
09/15/04
01/10/04

UCI
Incident Pre-Plan
Title: Revision No.
Biohazard Incident
Incident Recognition & Reporting
1
Section 4.0 – Authority/Responsibilities
UCI Biosafety Officer
Federal Bureau of Investigation
Responsible for developing and maintaining the
Incident Pre-plan for Biological Releases
UCI EH&S ERT Will provide assistance in management of any biohazardous material incident with guidance from UCI Biosafety Officer
Orange County Fire Authority (OCFA) Hazmat Municipal hazmat response authority outside the
UCI structure that would share incident command with UCI personnel
Orange County Health Care Agency Public Health agency with authority when there is a risk to the public or students are involved. The
Orange County Health Care Agency may also share incident command with the OCFA and UCI personnel.
Federal agency that will lead investigation if an incident of bioterrorism is suspected.
Section 5.0 – Procedures
Responsibility
Completed by (Initials)
Date/
Time
On-Scene
Follow instructions in the UCI Emergency
Procedures (blue flip chart) section titled
Hazardous Material Incidents http://www.ehs.uci.edu/eprepman/flipchrt.html
Evaluate spill and determine if assistance is needed. Only attempt a cleanup if the spill is minor and you have been properly trained.
If assistance is needed during normal business hours, call EH&S at (949) 824- 6200. After hours, call 911 from a campus phone.
If spill is large or of an unknown material, notify 911
Discoverer
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UCI
Incident Pre-Plan
Title:
Biohazard Incident
For unknown or suspected bioterrorism event, provide name, location, contact number and any first hand information about the substance.
Evacuate the area and isolate personnel who were potentially exposed.
If medical attention is needed, notify 911.
Initial Response
On-Scene
Activation
 Receive notification from UCIPD Dispatch or from campus personnel or students.


Follow the EH&S ERT Activation Flowchart in the EH&S ERT Plan to assemble ERT and ERT van at incident location.

Establish Command
 Establish a Command Post (CP) upwind of release and provide on-scene support.
Assess the incident potential – determine if incident is a non-emergency routine cleanup or a minor or major response (as classified by the EH&S ERT Activation
Flowchart).
Follow the ERT Activation Flowchart in the
EH&S ERT Plan (attached).
 Establish Unified Command (ICS) with the
OCFA and identify support roles if major response. If minor response, EH&S ERT will assume Command.
Revision No.
1
Responsibility
ERT On-Scene
Commander/
Biosafety Officer/
Safety Officer
ERT On-Scene
Commander/OCFA
IC/Biosafety Officer
Completed by (Initials)
Date/
Time
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UCI
Title:
Biohazard Incident
Incident Pre-Plan
Revision No.
1
Initial Response Responsibility
 Identify a triage officer, if needed
Size Up and Assessment
Conduct risk assessment using appropriate tools and Entry Hazard Guidelines in the EH&S ERT
Plan. Risk Assessment will include but may not be limited to:
 Review of Biohazardous Use Authorization form or Institutional Biosafety Committee
Protocol





Classification of Infectious Agents/Viral Vectors by Biosafety Level
Determination of potential for replication competency
Characterization of infectivity of vector
Nature of the transgenes which are to be expressed including toxins
Use of Select Agents (Infectious Agents or
Biological Toxins)
For suspected unknown agents, following sampling protocols in EH&S ERT Plan.
Conduct exposure monitoring to assist risk assessment efforts and establish hot/ cold (clean) zone perimeters.
ERT On-Scene
Commander/
Biosafety Officer
ERT On-Scene
Commander/
Biosafety Officer
On-Scene Safety
Officer
Determine if evacuation or shelter in place is required . Communicate to Zone Captain(s) as appropriate.
On-Scene
Commander
Completed by (Initials)
Date/
Time
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UCI
Title:
Biohazard Incident
Incident Pre-Plan
Initial Response
Scene Management & Control
 Designate decontamination sites for ERT and contaminated campus personnel.
Identify injury triage area, if needed. 
 Identify a staging area for equipment and personnel.
 Designate clean, uncontaminated assembly points for responders and campus community.
Implement shelter in place or evacuation plans
 Set-up safe zone/perimeter.
 Control vehicular traffic and help direct emergency responders to the site.
 Assist in arranging transportation to shuttle decontaminated staff to designated evacuation site for additional surveillance.
 Provide crowd control as well as assist with protective actions such as evacuations or sheltering in place if required by the incident action plan. If shelter in place will be required, provide control of entry/exit points.
If non-emergency or minor spill, prevent persons from entering area and tracking material until decontaminated and cleaned up.
Responsibility
On-Scene
Commander
Zone Captain(s)
Police Department
Commander, Fire
Department IC,
Campus Parking
Zone Crew
Revision No.
1
Completed by (Initials)
Date/
Time
If unknown biological is dispersed indoors:
Evacuate the building
Record names of all personnel potentially exposed
Keep personnel onsite for decontamination and treatment
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UCI
Title:
Biohazard Incident
Incident Pre-Plan
Initial Response
If unknown biological is dispersed outdoors:
Implement shelter in place procedure
Support
 Provide assistance by activating or deactivating
HVAC control equipment. Remote control capability exists for approximately 75% of the campus.
 Provide emergency lighting/power supply when needed.
Notify EH&S Director, Chief of Police and Vice
Chancellor A&BS to brief status. Provide recommendation on activation of EOC.
Revision No.
1
Responsibility
Facilities
Management,
Building Captains
ERT On-Scene
Commander
Completed by (Initials)
Date/
Time
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UCI
Title:
Biohazard Incident
Incident Pre-Plan
Incident Management
On-Scene
Strategic and Tactical Objectives
 Develop strategic approach: defensive vs. offensive.
 Identify strategic objectives.
 Develop tactical plan.
Develop Site Safety Plan for Tactical Operations and brief entry teams prior to entry.
Obtain resources and implement tactical plan for mitigation and clean-up.
Medical Treatment/Triage

 exposed.
Decontaminate as appropriate.
 Begin medical monitoring.
Resource and Information Management
 Develop and maintain situation and resource status reports.


Brief EOC Manager upon his/her arrival.
Schedule routine briefings with Response
Team and EOC.
Revision No.
1
Responsibility
ERT On-Scene
Commander/Unified
Command
Site Safety Officer/
Biosafety Officer
Operations Section
Chief
Site Safety Officer/
ERT On-Scene
Commander
Completed by (Initials)
Date/
Time
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UCI
Incident Pre-Plan
Title:
Biohazard Incident
Revision No.
1
Incident Management Responsibility
Request resources as needed from EOC Logistics:







Spill mitigation and clean-up equipment
Sampling and monitoring equipment
PPE
Lighting
Portable power sources
Portable ventilation (e.g. fans, HEPA units)
Support for CP (food, tables, chairs)
Arrange for Medical Support and monitoring. 
EOC
Activate applicable EOC Team Sections and
Positions based on On-Scene Commander briefing and overall incident assessment. Consider:






Overall impact to normal University operations.
Number of injuries and potential for additional injuries.
Environmental impact
Potential media involvement
Extent of response operations and the need for additional resources (e.g. cleanup and disposal)
Potential financial impact (including response clean-up costs, damage claims, business interruption, etc.)
Brief CEPG and decide if CEPG activation is warranted.
CEPG
Set up Crisis Management Center in Administration
Conference Room 536
Brief the CEPG on the current status of the incident including:
 Status of injuries
On-Scene
Commander or
Operations Chief
EOC Manager
EOC Manager/CEPG
EOC Logistics
Section Chief
EOC Manager
Completed by (Initials)
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Date/
Time

UCI
Title:
Biohazard Incident
Incident Pre-Plan
Incident Management






Extent of contamination
Impact on normal University operations
Media involvement
Student and public involvement
Agency involvement
Overall strategy and tactics
Conduct initial crisis assessment meeting
Identify immediate support needs and actions
Revision No.
1
Responsibility
CEPG
CEPG
Completed by (Initials)
Develop planning cases and existing and potential issues
CEPG
Develop actions for identified issues CEPG
Set meeting schedule for next CEPG meeting
Document CEPG meeting including immediate actions, issues to be discussed during the next meeting and distributing the meeting minutes to
CEPG members.
CEPG
CEPG Facilitator and support staff
Date/
Time page 9 of 14 Printed 04/16/20 726967779

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Title:
Biohazard Incident
Incident Pre-Plan
Revision No.
1
Termination Responsibility
On-Scene
Establish clean-up standards and incident termination criteria
Assure all potentially exposed personnel have been decontaminated, assessed and treated in accordance with Medical Plan/Site Safety Plan
Conduct a de-brief for all responders and clean-up personnel prior to departure. Include:
 Final documentation requirements


Follow-up procedures if signs or symptoms of exposure occur
Contact information (address, phone) for responders
Gather documentation and submit to
Documentation Unit of EOC or to the EH&S designated staff member (if EOC was not activated)
Restore all equipment back to a response ready condition:


Refuel all generators, vehicles, etc.
Replenish response consumables (e.g.

 disposable PPE, first aid supplies, etc.)
Clean and inspect tools
Note any deficiencies or needed repairs
EOC
Gather all response documentation from all
Sections
Complete final de-brief for EOC Team and CEPG,
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On-Scene
Commander or
Unified Command
On-Scene
Commander/Safety
Officer
On-Scene
Commander/Safety
Officer
On-Scene
Commander
On-Scene
Commander/ERT
Planning Section –
Documentation Unit
EOC Manager
Completed by (Initials)
Date/
Time
Printed 04/16/20

UCI
Incident Pre-Plan
Title: Revision No.
Biohazard Incident 1
Termination Responsibility
Completed by (Initials)
Date/
Time if activated.
Identify Post Incident Analysis Team for the purposes of re-constructing the response timeline.
Set deadline for Post Incident Analysis report.
EOC Manager
(optional)
Schedule response critique and lessons learned session(s)
CEPG
EOC Manager
Complete Crisis Management Team
Demobilization Checklist and determine need for continued sessions.
Assign final actions to team members/departments.
Shut down the Crisis Management Center and ready for future use
Section 6.0 – Definitions
6.1 Biosafety Levels:
CEPG Designated
Crisis Manager
CEPG Designated
Crisis Manger
EOC Logistics
Section Chief
Biosafety Level 1 practices, safety equipment, and facility design and construction are appropriate for undergraduate and secondary educational training and teaching laboratories, and for other laboratories in which work is done with defined and characterized strains of viable microorganisms not known to consistently cause disease in healthy adult humans. Bacillus subtilis, Naegleria gruberi, infectious canine hepatitis virus, and exempt organisms under the NIH Recombinant DNA Guidelines are representative of microorganisms meeting these criteria. Many agents not ordinarily associated with disease processes in humans are, however, opportunistic pathogens and may cause infection in the young, the aged, and immunodeficient or immunosuppressed individuals. Vaccine strains that have undergone multiple in vivo passages should not be considered avirulent simply because they are vaccine strains.
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UCI
Incident Pre-Plan
Title: Revision No.
Biohazard Incident 1
Biosafety Level 1 represents a basic level of containment that relies on standard microbiological practices with no special primary or secondary barriers recommended other than a sink for handwashing.
Biosafety Level 2 practices, equipment, and facility design and construction are applicable to clinical, diagnostic, teaching, and other laboratories in which work is done with the broad spectrum of indigenous moderate-risk agents that are present in the community and associated with human disease of varying severity. With good microbiological techniques, these agents can be used safely in activities conducted on the open bench, provided the potential for producing splashes or aerosols is low. Adenovirus, Salmonella, and Shigella spp. are representative of microorganisms assigned to this containment level. Biosafety Level 2 is appropriate when work is done with any human-derived blood, body fluids, tissues, or primary human cell lines where the presence of an infectious agent may be unknown. (Laboratory personnel working with human-derived materials should refer to the
CAL/OSHA Bloodborne Pathogen Standard (2) for specific required precautions.)
Primary hazards to personnel working with these agents relate to accidental percutaneous or mucous membrane exposures, or ingestion of infectious materials. Extreme caution should be taken with contaminated needles or sharp instruments. Even though organisms routinely manipulated at
Biosafety Level 2 are not known to be transmissible by the aerosol route, procedures with aerosol or high splash potential that may increase the risk of such personnel exposure must be conducted in primary containment equipment, or in devices such as a BSC or safety centrifuge cups. Other primary barriers should be used as appropriate, such as splash shields, face protection, gowns, and gloves.
Secondary barriers such as handwashing sinks and waste decontamination facilities must be available to reduce potential environmental contamination.
Biosafety Level 3 practices, safety equipment, and facility design and construction are applicable to clinical, diagnostic, teaching, research, or production facilities in which work is done with indigenous or exotic agents with a potential for respiratory transmission, and which may cause serious and potentially lethal infections. Mycobacterium tuberculosis , St. Louis encephalitis virus, and Coxiella burnetii are representative of the microorganisms assigned to this level. Primary hazards to personnel working with these agents relate to autoinoculation, ingestion, and exposure to infectious aerosols.
At Biosafety Level 3, more emphasis is placed on primary and secondary barriers to protect personnel in contiguous areas, the community, and the environment from exposure to potentially infectious aerosols. For example, all laboratory manipulations should be performed in a BSC or other enclosed equipment, such as a gas-tight aerosol generation chamber. Secondary barriers for this level include controlled access to the laboratory and ventilation requirements that minimize the release of infectious aerosols from the laboratory.
Biosafety Level 4 practices, safety equipment, and facility design and construction are applicable for work with dangerous and exotic agents that pose a high individual risk of life-threatening disease, which may be transmitted via the aerosol route and for which there is no available vaccine or therapy.
Agents with a close or identical antigenic relationship to Biosafety Level 4 agents also should be handled at this level. When sufficient data are obtained, work with these agents may continue at this level or at a lower level. Viruses such as Marburg or Congo-Crimean hemorrhagic fever are manipulated at Biosafety Level 4.
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UCI
Incident Pre-Plan
Title: Revision No.
Biohazard Incident 1
The primary hazards to personnel working with Biosafety Level 4 agents are respiratory exposure to infectious aerosols, mucous membrane or broken skin exposure to infectious droplets, and autoinoculation. All manipulations of potentially infectious diagnostic materials, isolates, and naturally or experimentally infected animals, pose a high risk of exposure and infection to laboratory personnel, the community, and the environment.
6.2 Decontamination: Destruction of microorganisms by chemical, steam autoclave or incineration or other means approved by the California Medical Waste Management Act.
Section 7.0 - Resources
7.1 Equipment
7.1.1 Clean-up: Sprayer, Bleach, Absorbent Material, Brushes
7.1.2 Personal Protective Equipment: Gloves, Goggles, Disposable Clothing (Tyvek coveralls), Respirators. Potential to require Level B Protection.
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UCI
Title:
Biohazard Incident
Page/Section Revision
Incident Pre-Plan
Page/Section
Revision No.
1
Revision
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