BSC 680 Special Topics in Cell Biology and Biotechnology INSTRUCTOR: Dr. J. Valluri Science Hall 370 Phone 696-2409 or leave message on Audix E-mail:valluri@marshall.edu This course is designed to allow in-depth exploration of one of a variety of topics of current interest in the field. The general topic will be designated by the instructor. A variety of formats may be used, including lecture, presentations, papers, and discussion. Course Objectives: In this course, we will explore the fundamental issues of biotechnology. What is biotechnology and how did it come about? How is biotechnology done and how is it being used today? What are the consequences of biotechnology applications to the lives of humans and other animals, plants, and to the environment? Students will learn techniques of recombinant DNA technology, develop an understanding of biotechnology industry product development, and examine ethical issues concerning biotechnology. Lecture Notes and Readings: There is no required text for this course, however, all lecture notes and links to readings, assignments, and biotechnology companies will be posted on my website. Web notes, readings and assignments will be available the Saturday before the next week's lecture. I ask you to come prepared to class ready to participate, ask questions and offer comments. We will invite speakers from area biotechnology companies or from other departments at Marshall University. Quizzes: Following each main topic there will be a quiz. The quiz dates will be announced to allow for adequate preparation. The quiz may vary in format and may include both multiple choice and short answer questions. Quizzes may not be made up for any reason; however, the lowest quiz grade will be dropped. Project: You will be each assigned a research topic (i.e., a biotechnology product, drug or a process) which you must present to the class. The date for each presentation will be announced in advance to allow for adequate preparation. All presentations must be in PowerPoint format and must not exceed 15 minutes. In addition, you must each submit a written report of your presentation. Attendance: Student attendance and participation will be required. Punctual attendance to lectures will be considered in the final grade. Grades: Your grade will be calculated as follows: Quizzes: Project: Final Exam 50% 25% 25% The final exam will be cumulative and will be given on Dec 11 at 12:45 PM. Your final grade in the class will be measured as follows: A: B: C: D: F: 90-100 80-89 70-79 60-70 Below 60 The last date to drop this class with a “W” is Oct 30. BSC 680 Syllabus Introduction to Biotechnology The Roots of DNA Research The Double Helix DNA in Action Overview of Key Issues in Biotechnology Methods in DNA Technology Health Care Applications: The Product Pipeline and Clinical Trials Human Proteins from DNA Technology Monoclonal Antibody drugs on the market Drug Delivery Gene Therapy Food and Agriculture GM Crop Biotechnology GM Food Biotechnology Animal Biotechnology: Cloning livestock Ag Bitoech products on the market Bioethics and Concerns of rDNA products: Asilomar and Recombinant DNA technology Embryonic Stem Cell Therapeutic cloning Genetic Information Nondiscrimination Act (GINA) 2007 Social Responsibility of Biotechnology Genome Gateway The Human Genome Project Comparitive Genomics - 'of Mice (orangutans, honeybees, opossums) and Men' Genomics, Proteomics, and other 'Omics Investing in Biotechnology Gene Patenting Patents and Intellectual Property (IP) Biotechnology Stock Project CHAPTER 1 The Roots of DNA Research CHAPTER 2 The Double Helix CHAPTER 3 DNA in Action CHAPTER 4 Introduction to Biotechnology CHAPTER 5 CHAPTER 6 Human Proteins from DNA Technology CHAPTER 7 Identifying Genetic Diseases CHAPTER 8 Gene Therapy CHAPTER 9 CHAPTER 10 Medical Forensics - DNA Sleuthing The Human Genome Project