CHAPTER 18 REVIEW QUESTIONS 18.1 a. b. A feedback system is a control mechanism whereby hormones interact with each other in a coordinated manner to maintain optimum internal conditions, e.g. ACTH secreted by the anterior pituitary stimulates the adrenal cortex to release cortisone or aldosterone which regulate aspects of metabolism. In a positive feedback system, the same response will continue to occur. Thus the presence of oestrogen maintains the production of FSH and secretion of LH. In a negative feedback system, the response is reversed or negated, e.g. a rise in the levels of progesterone inhibits FSH production. 18.2 The hypothalamus is a major sense organ that monitors many body functions. The nerve cells of the hypothalamus, in addition to producing ADH and oxytocin which are stored in the neurohypophysis and released under direction from the hypothalamus, produce hormones which act as release or release-inhibiting chemicals for hormones produced in the anterior pituitary gland (adenohypophysis). Thus it controls the release of a large number of hormones. Since five of the seven hormones produced by the adenohypophysis are tropic hormones that influence other endocrine glands, the pituitary is termed the master gland. 18.3 Thyroxine is a hormone produced by the thyroid gland that increases metabolic rate by stimulating cell respiration. The production and/or release of thyroxine is under the control of a hormone, TSH, secreted by the anterior pituitary. When the pituitary is stimulated by the hypothalamus, it secretes TSH which in turn stimulates the thyroid. Lack of TSH in the blood inhibits thyroxine secretion. 18.4 The hormones are ‘captured’ by recognition sites on the cell membrane. The interaction between the recognition site and the hormone bring about changes in specific chemical reactions by: stimulating the activity of specific genes in the nucleus influencing the permeability of the cells to particular solutes or inducing or repressing cytoplasmic enzymes and thus specific chemical reactions. 18.5 18.6 The membrane of the neurone in the resting state is polarised, i.e. the inside of the membrane is negative relative to the outside as a result of the active removal of sodium ions. This removal results in an influx of positively charged potassium ions but large, negatively charged organic molecules in the cytoplasm maintain the negative internal charge. This results in an electrical potential difference across the membrane. When an impulse reaches the membrane, the sodium pump is momentarily broken down and the membrane becomes depolarised. Sodium ions rush into the neurone at that point along a concentration gradient. When the membrane potential is reversed (the inside is now positively charged relative to the outside) an action potential is said to occur. Restoration of the resting potential starts almost immediately but as this is occurring the action potential stimulates the depolarisation of the adjacent polarised section of the membrane. Repolarisation begins with an efflux of potassium ions, followed by the restoration of the sodium pump that results in sodium ions again being actively removed to the outside of the membrane followed by return of the potassium ions to the inside. The time during which this occurs is termed the recovery period, during which a further action potential cannot occur. 18.7 The stimulus for an action potential must be of a minimum strength (the threshold stimulus) after which an increase in stimulus strength does not alter the magnitude of the action potential. 18.8 Transmitter substances are only produced at one side (the axonic knob) of the synapse. This chemical is needed to pass across the synaptic cleft and so stimulate an action potential in the post-synaptic (dendrite) membrane. Thus the stimulus can only pass in one direction from neurone to neurone. 18.9 Central Nervous system (brain and spinal cord). Peripheral Nervous system divided into Somatic (outer body tube) and Visceral (inner body tube and associated organs) Nervous system, each composed of sensory (input) nerves and motor (output) nerves. The Visceral motor nerves are further subdivided into Parasympathetic and Sympathetic systems which have antagonistic effects on the organs they innervate due to different transmitter chemicals. 18.10 salivary glands – effector sound – stimulus message – impulse brain – central nervous system 18.11 a. b. c. d. 18.12 Sensory neurones take impulses to the central nervous system where they may be relayed to other parts of the CNS by association neurones for coordination. The response impulse is transmitted in motor neurones from the CNS to the effector organ. 18.13 A reflex arc is a simple nerve pathway which does not involve coordination, it involves a sensory neurone which may make direct synaptic contact with the appropriate motor neurone although an association neurone, taking the impulse to the opposite side of the body or a different body segment, is usually involved (see Biology: An Australian Perspective Second Edition textbook, Figure 18.14). 18.14 The energy of the stimulus impinging on the sensory organ (eg. heat, light, pressure, vibrations, chemicals) is converted into the energy of an action potential by the sense organ. 18.15 The iris, by contraction and expansion, controls the amount of light entering the eye. 18.16 Rods are extremely sensitive to low light intensity. Three different types of cones, each with a different pigment system, are stimulated by different frequencies of light to effect colour vision. cerebrum spinal cord cerebellum medulla oblongata 18.17 The light is reflected from the object and passes through the cornea and into the pupil (the size of which is determined by the iris) of the eye to the lens. The lens focuses the light rays to form an image on the retina at the back of the eye. Light sensitive cells in the retina convert light energy to the energy of an action potential which is transmitted to the optic nerve fibres and passed to the optic centres of the brain which translate the frequency and number of messages as a visual image. 18.18 The ear is stimulated by movement of air particles. The vibrations of air are transmitted to through three bones in the middle ear to the fluid of the inner ear. Within the Organ of Corti in the inner ear, tufts of hair on sensory cells vibrate in response to different frequencies of vibration of the fluid. This mechanical energy is then transformed to an action potential which is sent to the auditory centres of the brain and perceived as sound. 18.19 a. b. The alimentary canal has an outer layer of connective tissues continuous with thin supporting membranes which hold it in position. Inside this layer are two layers of involuntary muscle, an outer longitudinal and inner circular layer, that are responsible for peristalsis. The muscle is connected on its inner surface to another connective tissue layer within which are found the major blood and lymphatic vessels, nerve fibres and stretch receptors. The inner lining of the alimentary canal consists of smooth muscle fibres and loose connecting tissue which support the epithelium. Glands are derived from this epithelium. The oesophagus is not associated with digestion but merely transfers food through the thoracic cavity to the stomach. Since the food is in a poorly digested state at this point, the lining needs to be protected from mechanical damage (rough edges of food, heat, cold). The epithelium, therefore, is devoid of glands and is thick and stratified, the very inner layer of cells being dead. The stomach is a large storage organ in which preliminary digestion of proteins occurs and which is the major organ of physical digestion. It is therefore an enlarged, sac-like structure. An additional, oblique, layer of muscles adds to the movement possible by the stomach, producing the churning of the food to break it into smaller particles for enzyme action. The lining of the stomach wall is glandular, producing both mucous which protects the wall from digestive enzymes, and digestive juices (proteolytic enzymes and acid). The small intestine is the major site of digestion and absorption of soluble molecules. The inner epithelium is highly folded, forming finger-like projections called villi and each of the cells has small projections called microvilli. The villi and microvilli increase the surface area available for absorption as well as help circulate the food within the canal. The epithelium is highly glandular, different glands producing enzymes, mucous and alkaline solutions which aid these digestive enzymes. The large intestine is involved in the microbial digestion of cellulose, compaction of undigested food by absorption of water, and egestion. It has an almost smooth epithelial lining. The muscular sphincter surrounding the anus has an additional layer of striated muscle so that some voluntary control of egestion can be achieved. 18.20 The walls of the glands and ducts contain protein (e.g. cell membranes, muscles and fibres). If proteolytic enzymes were produced and secreted in an active form they would start to digest the glandular cells and their ducts. 18.21 D 18.22 C 18.23 The epithelium is folded (slowing down the movement of chyme) and thrown into finger-like villi (increase surface area and aid circulation of chyme). Each epithelial cell also has small projections, the microvilli (further increase surface area for absorption). The villi are highly vascularised and contain lacteals for the rapid removal of absorbed material. 18.24 Fat digestion begins in the mouth by the physical breakdown by teeth and rolling of the tongue. Physical digestion continues in the stomach due to the muscular churning created by the stomach wall. In the duodenum, bile salts from the liver bring about emulsification of the lipids, breaking them into small droplets with a large surface area : volume ratio. These droplets are then acted upon by lipases secreted by intestinal glands and the pancreas which hydrolyse the lipid molecules into fatty acids and glycerol. Very small droplets of lipids and the fatty acids and glycerol are absorbed into lacteals which join, via larger lymphatic vessels, with the major vein just prior to its entry into the heart. The molecules are then circulated to the appropriate cells for assimilation. A small amount of fatty acids and glycerol are also absorbed directly into the capillaries of the villi. 18.25 a. b. c. d. e. 18.26 a b. c. Peristaltic contractions are rhythmic movements caused by alternative contraction and relaxation of the muscles of the alimentary canal wall. Chyme refers to the state of the food resulting from physical digestion, primarily in the stomach. The food has been broken down into small particles which has a soupy consistency. Emulsification is the process whereby fats are dispersed as small droplets in a water solution. Because of their hydrophobic tails, fat molecules in water tend to clump together to avoid the repulsive forces between the tails and water. The bile salts are able to interact with small groups of lipid molecules and reduce the repulsive forces. Bile salts are involved in physical not chemical digestion – emulsification does not involve hydrolysis of the lipid molecules, merely separation of large groups of molecules into smaller groups of molecules. Pepsin and rennin require a low pH for their optimum operation. The presence of acid aids in the breaking of binds holding the secondary and tertiary structure of the protein. It mediates in the conversion of amylose in starch to the disaccharide maltose. Peristalsis is instigated once food enters the oesophagus. These involuntary contractions of the muscles move in a wave from the pharynx to the stomach. Food in the pharynx sparks a reflex action in which causes movement of the epiglottis across the windpipe and thus entry of food into the oesophagus which starts peristaltic movement, creating a negative pressure which draws food into it. Efficient fat digestion requires its emulsification. If the bile duct is blocked this is not achieved. Thus lipase can only act on the outer edges of large groups of lipid molecules, having inadequate time in the small intestine to achieve complete digestion. 18.27 The stomach is a storage area, the main function of which is physical digestion and the initial digestion of proteins. Removal of the stomach does not preclude a fairly normal diet. The food eaten, however, would need to be of a fine consistency (pre-physically digested) and taken in small amounts at regular intervals (since storage of large amounts is not possible). 18.28 a. b. c. d. Rennin. The rennet causes the milk proteins to come out of solution and clump together. The stomach. The clumped proteins are more available for the action of proteolytic enzymes than when they are in solution. 18.29 a. b. The Islets of Langerhans of the pancreas. They are transported in the blood to the liver which controls blood sugar levels. 18.30 Insulin is secreted directly into the blood system, through which it flows to the liver. Pancreatic juice is secreted from the Acini cells into the pancreatic duct where it travels directly to the duodenum. 18.31 To prevent them digesting the glandular tissue and ducts. 1832 The liver is the major site of metabolism of food. 18.33 Each liver lobule is hexagonal in cross-section, composed of cords of cells radiating out from a central branch of the Hepatic Vein. Between the cords of cells are sinusoids, open spaces bathed with blood from the capillaries of the Hepatic Portal Artery and Hepatic Artery found at the corners of each lobule. Bile canaliculi run parallel to the sinusoids, the direction of flow being opposite to that of the sinusoids. The canaliculi drain into ducts at the edge of the lobule. 18.34 The Hepatic Artery carries oxygen and metabolites whereas the Hepatic Portal Vein is a shortcircuiting vessel, carrying digested food directly from the small intestine. 18.35 The liver is involved in reception and storage of digested food, carbohydrate metabolism, conversion of excess amino acids, fat metabolism, secretion of bile, storage of iron, vitamins A, D and B12, manufacture of plasma proteins, production of heat, defence and detoxification. 18.3 18.37 The walls of the trachea (bronchi and major branches) contain incomplete cartilaginous rings that ensure that the lumen remains open but retains flexibility so that both changes in diameter and length can occur. The internal surfaces are lined with ciliated epithelium through which mucous secreting goblet cells are dispersed. The mucous traps small particles of dust, bacteria and other matter in the air. The beating cilia move the mucous with its trapped particles towards the pharynx. 18.38 Each alveolus is covered by a capillary network ensuring a large surface area for gas exchange. The walls of the alveolus and the capillary, both only one cell thick, are in close contact, being separated by only a thin layer of elastic connective tissue. The diffusion pathway is therefore very short. The connective tissue allows for expansion and contraction of the alveolus with ventilation. Some cells in the alveolar wall secrete a lubricating fluid which decreases the surface tension on the walls and thus helping to keep the alveolar open. Moisture within the alveolus also allows oxygen to dissolve and so pass readily across the membranes. 18.39 The volume of the thorax is changed via movements of the intercostal muscles and the diaphragm, creating air pressure differences in the lungs. Air moves into the lungs when the volume of the thorax is increased (low air pressure relative to the air) and is expired when the volume of the thorax is decreased (increased air pressure relative to the air). 18.40 Vital capacity is the maximum amount of air that can be ventilated during forced breathing. Tidal volume is the volume of air moving in and out of the lungs during normal breathing. 18.41 In terrestrial animals the oxygen concentration in the air is relatively high and so levels of oxygen in the blood can be adequate whilst carbon dioxide can accumulate. The carbon dioxide reacts with water in tissue fluids and the blood to form carbonic acid which dissociates into hydrogen and bicarbonate ions. The lowered pH so created can cause enzyme inhibition. Thus detection and correction of blood pH (which translates into carbon dioxide levels) is important to terrestrial animals. 18.42 As the level of activity increases, so does aerobic respiration and the production of carbon dioxide. pH sensors in the major arteries and the tissue fluid surrounding the hind brain transmit information to the respiratory centres in the hind brain which bring about increases in the rate and depth of breathing, increasing the rate of gas exchange. These changes are accompanied by increased heart rate and dilation of the arteries, ensuring a more rapid supply of blood to the organs undergoing increased activity. 18.43 Lungs are emptied before diving and the dive is rapid. The surrounding water pressure thus compresses the thorax and lungs, driving alveolar air out of the lungs. The thoracic cavity is adapted to allow this compression. Nitrogen is thereby prevented from entering the blood. At pressure nitrogen goes into solution and high concentrations cause narcosis. As pressure decreases when the animal resurfaces, the nitrogen would come out of solution in the blood, blocking blood vessels which may result in paralysis (the bends). Other adaptations include: Higher blood volume and oxygen-carrying capacity than terrestrial animals – the blood can be loaded with oxygen by hyperventilation prior to the dive. High concentrations of myoglobin in the muscles – myoglobin stores oxygen which can be used for aerobic respiration when haemoglobin supplies are depleted. Blood supply is shunted away from the muscles but maintained to the heart and brain – the stroke rate of the heart can be decreased, which is less energy demanding whilst maintaining essential oxygen supply to the brain. Vascoconstriction ensures oxygen debt incurred by anaerobic respiration in muscle cells is restricted to the muscles. The muscle cells can tolerate higher than normal terrestrial lactic acid accumulation – prevents lactic acid toxicity to other tissues and organs. 18.44 With increased altitude, atmospheric pressure, gas particles, absolute humidity and temperature decrease. Mammals have a constant body temperature and thus a constant partial pressure for water vapour and carbon dioxide. At high altitudes with decreased air pressure, the volume of alveolar space taken up by water vapour and carbon dioxide is high, and the availability of oxygen decreases more rapidly in the alveoli than in the air. 18.45 Initially there is an increased ventilation rate, which over a period of time is accompanied by: correction of blood pH (due to carbon dioxide accumulation) by the kidney increased production of red blood cells and haemoglobin increase in blood volume and tissue capillaries enzyme acquisition which increases the efficiency of oxygen utilisation enlargement of the thorax to allow a greater ventilation volume. 18.46 a. b. c. d. e. f. g. h. i. j. k. l. m. n. o. p. q. r. s. t. u. v. w. x. y. artery – thick walled vessel transporting blood away from the heart. atrium – chamber of heart which receives blood from veins. atrioventricular valve – tissue found between the atrium and ventricle of the heart to control the flow of blood. arterial pressure – blood pressure developed in arteries as it is pumped from the heart by the contraction of the ventricular wall muscles. valve – [textbook error: disregard this term] blood – transporting fluid in animals. bicuspid valve – atrioventricular valve between the left atrium and ventricle, consisting of two flaps or cusps. capillary – small diameter blood vessel whose walls are only one cell thick and through which exchange of matter with tissue fluid occurs. coronary vessel – blood vessel servicing the heart muscles. closed circulation – circulatory system in which the blood is moved throughout the body in vessels. diastole – stage in the heart cycle when the muscles are relaxed, allowing the chambers to fill with blood. double circulation – circulatory system where the blood passes through the heart twice each circuit of the body. lymph – tissue fluid containing a high proportion of white blood cells which has been taken up by the lymphatic vessels to be returned to the blood vascular system. plasma – fluid part of the blood composed of serum (water in which proteins and dissolved substances are suspended) and fibrinogen. platelet – cell fragments found in the blood, which are involved in the clotting process. portal vein – a vessel which starts and ends in a capillary bed. red blood cell – blood cell specialised for the transport of respiratory gases by the inclusion of the pigment haemoglobin; enucleate in mammals. serum – plasma minus fibrinogen. semilunar valve – flaps of tissue found at the origin of the arteries leaving the heart, that prevents backflow of blood during diastole. systole – stage in the heart cycle when the muscles are contracted and blood is forcible ejected into the arteries. tissue fluid – fluid formed from plasma pushed out through the walls of the capillaries under arterial pressure; surrounds cells, providing a medium for exchange between the cells and blood. tricuspid valve – right atrioventricular valve consisting of three cusps. vein - thin walled blood vessel which returns blood to the heart. ventricle – highly muscular chamber of the heart provides pressure for blood to circulate in arteries. venule – small branch of a vein formed by joining of capillaries. 18.47 Plasma – transport of nutrients, waste products, hormones and heat. Red blood cells – transport of respiratory gases. White blood cells Neutrophils – phagocytes Eosinophils – allergic reaction Basophils – inflammation reactions; produce heparin - prevent to clotting Lymphocytes – antibody formation Monocytes – phagocytic Platelets – release fibrin from fibrinogen in clotting of blood. 18.48 Fibrinogen is the soluble, inactive pre-cursor substance which forms insoluble fibrin when activated. Fibrin brings about clotting of the blood. 18.49 a. b. Oxygen combines with haemoglobin to form oxyhaemoglobin. This is a loose union that allows rapid detatchment of the oxygen when the concentration of oxygen (as in capillaries in tissues) is low and attachment when the concentration (as in the capillaries of the lung) is high. Carbon dioxide is mostly transported as bicarbonate ions in the red blood cells although some is combined with haemoglobin. 18.50 a. b. The uptake and release of oxygen by haemoglobin is determined by the pH of the blood and the amount of oxygen present in the plasma. Changes in pH result from the presence or absence of carbon dioxide. When carbon dioxide is present it combines with water to form carbonic acid. This dissociates into hydrogen and bicarbonate ions. A low pH favours unloading of oxygen from haemoglobin. Thus in the alveoli of the lungs, the carbon dioxide tension is low and oxygen tension is high. Carbon dioxide is reformed from bicarbonate and hydrogen ions and diffuses out of the blood. Oxygen passes into the blood along the diffusion gradient where it combines with haemoglobin. In actively respiring tissues, and thus the surrounding tissue fluid, carbon dioxide tensions are high and oxygen tensions are low relative to the plasma in the capillaries. Carbon dioxide diffuses into the red blood cells where it forms carbonic acid. The lowered pH causes the haemoglobin to release oxygen molecules which then pass into the tissue fluid along the diffusion gradient. 18.51 In the alveoli of the lungs the oxygen tension is high and carbon dioxide tension low relative to the blood. Carbon dioxide passes out of the blood into the alveoli and oxygen enters the blood and red blood cells. With low carbon dioxide and high oxygen in the red blood cells, haemoglobin uptake of oxygen is very rapid. In the tissue fluid of respiring cells surrounding capillaries, carbon dioxide tension is high and oxygen low. Carbon dioxide diffuses into the blood and red blood cells where it forms carbonic acid. The lowered pH results in very rapid unloading of oxygen which then diffuses into the tissue fluids. 18.52 The Bohr shift is a shift to the right of the oxygen dissociation curve when carbon dioxide levels are increased – oxygen is only loaded when its tensions are higher than normal in the red blood cells and conversely it is unloaded at higher than normal oxygen levels. 18.53 Excess bicarbonate ions formed by the dissociation of carbonic acid in the red blood cell pass into the plasma. The membrane is relatively impermeable to positive ions so that unless another negative ion (chloride) enters the red blood cell, there would be an ionic imbalance in the red blood cell. 18.54 a. b. 1 2 3 4 5 6 7 8 9 i. right ventricle tricuspid valve right atrium semilunar valve dorsal aorta left atrium bicuspid valve left ventricle muscular wall of left ventricle 9 is thicker than 1 – it needs to exert a greater pressure to force the blood right around the body rather than just to the lungs (1). ii. 9 is much thicker than 6 since the atrium is merely a receiving chamber that transfers blood to 9. c. Structure 1 3 8 9 2 18.55 a. b. c. 18.56 Condition Relaxing Contracting Changes in the internal environment are monitored by the brain and appropriate changes to the rate of contraction of cardiac muscle can be achieved. Sympathetic nerve activation increases heart beat and Parasympathetic nerve activation decreases it. The nerves stimulate a specific part of the muscle of the right atrium – the sino-atrial node (pacemaker), causing a series of chemical changes in the muscle cells which result in contraction. The chemical changes pass from muscle cell to cell bringing about a wave of muscular contraction across the atrium walls. At the atrioventricular node (the only part of the atrium not separated from the ventricle by connective tissue) the wave of contraction is passed on to the ventricles via the Purkinji fibres. Thus systole starts with contraction of the atria (blood flows into the ventricles), followed by ventricular contraction (the atria relax and atrioventricular valves close to prevent backflow of blood so that blood is forced into the arteries) and ventricular relaxation (diastole which is associated with closing of the semilunar valves and opening of the atrioventricular valves). Blood pressure is a measure of the pressure exerted on the blood in the arteries by the action of cardiac muscle. When the muscle contracts, it decreases the volume of the ventricle, and thus increases pressure, forcing blood into the arteries. During diastole, there is not further pressure exerted on the blood in the arteries by the heart, thus it decreases. The high number in the reading (140) indicates systolic pressure whilst the low number (85) indicates diastolic pressure. 18.57 Fluid Plasma Tissue fluid Lymph Structure Serum (water plus globular proteins and dissolved substances) plus fibrinogen. Water and dissolved substances. Tissue fluid with a large number of white blood cells and lipid molecules. Function Transport of nutrients, products, hormones and heat. waste Exchange of materials between the blood and the cells. Absorption of fatty acids and glycerol from small intestine; return of tissue fluid to the heart; phagocytosis of foreign matter. 18.58 a. b. 18.59 a. b. c. d. e. f. g. h. i. j. k. l. m. n. A system where two vessels (or a vessel and movement of the external environment), in close parallel proximity, transport material in opposite directions. Blood flowing in an artery from the warm, central body core to the cold extremities will lose heat to the environment. If the vein returning cold blood from the extremities runs in a counter-current to the artery, heat will be transferred from the artery all along the length of the vein which will be at a lower temperature and thus heat loss to the environment is minimised. Bowman’s capsule – the cup-shaped beginning of the nephron, through which blood is filtered under pressure. pyramid – conical shaped lobe of the kidney medulla. isotonic – having the same concentration as that of the surroundings. ureter – duct formed by the collecting ducts draining the nephrons which transports urine to the bladder. cortex – outer, dark-coloured layer of the kidney. ultrafiltration – filtration of blood out of a capillary under higher than normal blood pressure. medulla – the inner, lighter-coloured layer of the kidney which surrounds the central cavity. hypertonic – at a higher concentration than the surroundings. hypotonic – at a lower concentration than the surroundings. convoluted tubule – highly coiled tubules of the nephron on either side of the loop of Henle. loop of Henle – a U-shaped portion of the nephron in which water is reabsorbed. glomerulus – group of blood capillaries through which ultrafiltration into Bowman’s capsule occurs. urethra – the tube through which urine passes from the bladder to the external environment. pelvis – the expanded proximal portion of the ureter within the central cavity of the kidney. 18.60 As evaporation from the skin, on expiration and in urine. 18.61 A: urethra. 18.62 C: cortex. 18.63 a. b. c. d. e. f. g. h. renal artery glomerulus nephron (Bowman’s capsule) plasma proteins mineral salts sodium chloride molecules osmosis sodium chloride 18.64 a. b. c. d. Large amount of dilute urine. Scant, concentrated urine. Scant, concentrated urine. Scant urine of ‘normal’ concentration. 18.65 a. b. Removal of metabolic wastes. Maintenance of the correct water balance. i. j. k. l. m. n. o. p. ascending tissue fluids hypertonic hypothalamus brain ADH decreases less