Module 2. Analysis of the quality of drug substances of aromatic structure, which are used as components of pharmaceuticals.
COONa
1. The structural formula corresponds to a drug:
A.
B.
C.
D.
E.
Sodium salicylate
Benzoic acid
Salicylic acid
Sodium acetate
*Sodium benzoate
O
C
OH
2.
The structural formula corresponds to a drug:
A.
B.
C.
D.
E.
Acetic acid
Salicylic acid
Resorcinol
Phenol
*Benzoic acid
OH
3.
The structural formula corresponds to a drug:
A.
B.
C.
D.
E.
Methanol
Xeroform
Salicylic acid
Phenol
*Resorcinol
OH
O
C
ONa
OH 4.
The structural formula corresponds to a drug:
A.
B.
C.
D.
E.
Benzoic acid
Salicylic acid
Sodium benzoate
Sodium acetate
*Sodium salicylate
5.
The structural formula corresponds to a drug:
A.
Procaine
B.
C.
D.
E.
Acetylsalicylic acid
Phenyl salicylate
Salicylanilide
*Paracetamol
OH
O
NH C
CH
3
6.
The structural formula corresponds to a drug:
A.
Salicylic acid
O
C
HN
OH
Î Í

B.
C.
D.
E.
Salicylamide
Phenyl salicylate
Salicylanilide
*Oxaphenamide
O
C
HN
OH 7.
The structural formula corresponds to a drug:
A.
B.
C.
D.
E.
Salicylic acid
Salicylamide
Acetylsalicylic acid
Phenyl salicylate
*Salicylanilide
O
C
NH
2
OH 8.
The structural formula corresponds to a drug:
A.
B.
C.
D.
E.
Salicylic acid
Acetylsalicylic acid
Phenyl salicylate
Salicylanilide
*Salicylamide
9.
The structural formula corresponds to a drug:
A.
Salicylic acid
B.
C.
D.
E.
Benzyl benzoate
Phenyl salicylate
Salicylanilide
*Acetylsalicylic acid
10.
The structural formula corresponds to a drug:
A.
B.
C.
D.
E.
Salicylic acid
Benzyl benzoate
Acetylsalicylic acid
Salicylanilide
*Phenyl salicylate
C
O
O C
6
H
5
OH
C
O
O CH
3
OH 11.
The structural formula corresponds to a drug:
A.
B.
C.
D.
E.
Salicylic acid
Acetylsalicylic acid
Phenyl salicylate
Salicylanilide
*Methylsalicylate
C
O
OH
O Ñ
O
СН
3

Ñ O
O
C
H
2
12.
The structural formula corresponds to a drug:
A.
Salicylic acid
B.
C.
Acetylsalicylic acid
Phenyl salicylate
D.
E.
Salicylanilide
*Benzyl benzoate
ÑOOH
13.
The structural formula corresponds to a drug:
A.
B.
C.
D.
E.
Xeroform
Acetylsalicylic acid
Benzoic acid
Salicylanilide
*Salicylic acid
14.
The structural formula corresponds to a drug:
Br Br
Br
A.
B.
C.
D.
E.
Bismuthite
Br
Thymol
Resorcinol
Phenol
*Xeroform
O Bi O
OH
Br
OH
Br .
Bi
2
O
3
CH
3
15.
The structural formula corresponds to a drug:
CH
3
A.
Menthol
Xeroform B.
C.
D.
E.
Resorcinol
Phenol
*Thymol
C
H
OH
CH
3
16.
The structural formula corresponds to a drug:
A.
Glutamic acid
Benzoic acid B.
C.
D.
Thymol
Methionine
OH

E.
*Phenol
17.
For identification of acetylsalicylic acid chemist used dilute sodium hydroxide solution R. After boiling and next cooling he added dilute sulphuric acid R. What product of reaction is formed?
A.
Smoke
Opalescense B.
C.
D.
Green precipitate
Brown gas
E.
*White precipitate
18.
The pharmacopoeial method of assay for benzyl benzoate is back acid-base titration of alkaline hydrolysis products.What is titrant in this method?
A.
Silver nitrate
Sodium hydroxyde B.
C.
D.
E.
Potassium hydroxyde
Perchloric acid
*Chloride acid
19.
The physical method, which is used for the analysis of paracetamol, according to Pharmacopoeia, is:
A.
Polarimetry
B.
C.
D.
E.
Refractometry
Tin layer chromatography
Gas chromatography
*Melting point
20.
The method of assay for salicylamide is:
A.
B.
C.
D.
E.
Iodometry, direct titration
Cerymetry, back titration
Permanganatometry
Argentometry, back titration
*Modified Keldal method
21.
Salicylanilide use as agent:
A.
B.
C.
D.
Purgative
Anaestetic
Keratolytic
Analgesic and antipyretic
E.
*Antibacterial
22.
The molar weight of equivalent (Em) at assay of acetylsalicylic acid by means of acidimetry after saponification alcoholic solution (back titration) equals:
A.
М m.
B.
М m./4
C.
D.
E.
2М. M.
М m./3
*М m./2
23.
The chemical name of benzyl benzoate is:
A.
B.
C.
2-(Acetoxy)benzoic acid o-Hydroxybenzamide
Phenylsalicylamide
D.
E.
p-Oxyphenylsalicylamide
*Phenylmethyl benzoate
24.
The initial substance for synthesis oxaphenamide is:
A.
Pyrogalol
B.
C.
D.
E.
Toluene
Resorcinol
Phenol
*Phenyl salicylate
25.
Phenolic hydroxyl in paracetamol molecule it is possible to identify by means reactions with:
A.
B.
C.
FeCl
3
, CuSO
4
AgNO
3
, HNO
3
FeCl
2
, KCl
D.
HCl, NaNO
3

E.
*FeCl
3
, diazonium salts
26.
What titrant can be used for assay of paracetamol by means of nitritometry (direct titration)?
A.
B.
C.
D.
E.
Nitric acid
Sodium nitrite in the alkaline medium
Chloride acid
Sodium chloride
*Sodium nitrite in the acid medium
27.
The Pharmacopoeial method of assay for definition methyl salicylate is:
A.
B.
C.
D.
Nitritometry
Permanganatometry
Iodometry
Alkalimetry after alkaline hydrolysis
E.
*Acidimetry after preliminary alkaline hydrolysis
28.
Methyl salicylate can be synthesed by means of boiling in the presence of sulphatic acid:
A.
B.
C.
Sodium benzoate with ethane
Sodium salicylate with methane
Resorcinil with ethanol
D.
E.
Benzoic acids with methanol
*Salicylic acid with methanol
29.
What can be observed the chemist-analyst at addition to alcoholic solution of phenyl salicylate solution iron (ІІІ) chloride FeCl3?
A.
B.
C.
D.
White smoke
Green solution
White precipitate
Allocation of poisoning gas
E.
*Violet colouring of solution
30.
Under the description salicylanilide represents:
A.
B.
C.
D.
White, crystalline powder or small, colourless crystals or shiny flakes
Amorphous substance of yellow colour with specific smell
White, crystalline powder or white or colourless, acicular crystals
White, crystalline powder or colourless crystals, odourless or with a very slight characteristic odour
E.
*White or yellowish crystal powder, baking taste.
31.
What functional groups are available in a molecule salicylamide?
A.
B.
C.
Keto-group, amide group
Integrally connected chlorine
D.
E.
Alcoholic hydroxyl, amino group
Amino group, benzene cycle
*Amide group, phenolic hydroxyl
32.
Assay of acetylsalicylic acid, according to Pharmacopoeia, makes by means of such method:
A.
Alkalimetry, back titration
B.
C.
D.
Argentometry
Acidimetry, non-aqueous direct titration
Alkalimetry in alcoholic solution, direct titration
E.
*Acidimetry, after saponification alcoholic solution, back titration
33.
The initial substances for synthesis benzyl benzoate is:
A.
B.
C.
D.
E.
Pyrogalol
Toluene
Resorcinol
Phenol
*Sodium benzoate
34.
Paracetamol in medical practice apply as means:
A.
B.
C.
D.
E.
Purgative
Antimicrobial preservative
Keratolytic
Expectorant
*Analgesic and antipyretic.

35.
The chemical name of oxaphenamide:
A.
B.
C.
D.
Phenylmethyl benzoate
Phenyl ester 2-oxybenzoic acid
Methyl 2-hydroxybenzoate p-Acetaminophenol
E.
*p-Oxyphenylsalicylamide
36.
In the medical practice the benzoic acid use as agent:
A.
B.
C.
D.
E.
Purgative
Anti-inflammatory; analgesic
Keratolytic
Expectorant
*Antimicrobial preservative
37.
What indicator must be used, according to Pharmacopoeia, for assay of sodium benzoate in the method of acidimetry, non-aqueous direct titration?
A.
B.
C.
Any
Methyl orange
Phenolphthalein
D.
E.
Phenol red solution
*Naphtholbenzein solution
38.
What pharmacopoeial method of assay for salicylic acid?
A.
Acidimetry, non-aqueous back titration
B.
C.
D.
E.
Argentometry
Acidimetry, non-aqueous direct titration
Alkalimetry, back titration
*Alkalimetry in alcoholic solution, direct titration
39.
For identification of sodium benzoate the chemist-analyst makes sublimation of dug (some crystals of the crushed drug moisten with sulphatic acid R, cautiously heat up a test tube bottom). What he observed?
A.
B.
C.
D.
Smoke
Opalescense
Green precipitate
Brown gas
E.
*White scurf
40.
At decarboxylation of salicylic acid (heating with concentrated sulphatic acid) chemist-analyst observed allocation of gas bubles. What gas allocated?
A.
B.
C.
D.
Hydrogen
Sulphur dioxide
Carbon oxide
Oxygen
E.
*Carbon dioxide
41.
For identification of benzoic acid the chemist-analyst, according to Pharmacopoeia, uses reaction with:
A.
B.
Perchloric acid
Potassium hydroxyde
C.
D.
Nitric acid
Wine acid
E.
*Iron (ІІІ) chloride
42.
For identification of ions of Sodium in sodium benzoate the chemist-analyst can use reaction with:
A.
B.
C.
D.
Iron (ІІІ) chloride
Potassium hydroxyde
Wine acid
Silver nitrate
E.
*Methoxyphenylacetic acid reagent
43.
Under the description sodium salicylate is:
A.
B.
C.
Amorphous substance of yellow colour with specific smell
Black crystalline powder, acicular crystals
Green crystalline or granular powder or flakes

D.
E.
Colourless crystals, odourless or with a very slight characteristic odour
*White, crystalline powder or small, colourless crystals or shiny flakes
44.
The initial substance for synthesis of sodium benzoate is:
A.
Pyrocatechol
B.
C.
D.
Toluene
Salicylic acid
Phenol
E.
*Benzoic acid
45.
The chemical name of salicylic acid:
A.
B.
C.
D.
E.
Oxybenzene
Sodium benzenecarboxylate
Benzenecarboxylic acid
2-Methyloxybenzenecarboxylic acid
*2-Hydroxybenzenecarboxylic acid
46.
In the medical practice sodium benzoate use as means:
A.
B.
C.
D.
Purgative
Anti-inflammatory; analgesic
Keratolytic
Antimicrobial preservative
E.
*Expectorant
47.
The equivalent weight (Em) at assay of salicylic acid by means of alkalimetry in alcoholic solution is:
A.
B.
C.
М m./2
М m./3
М m./4
D.
E.
2М. M.
*М m.
48.
Pharmacopoeial method of assay for sodium benzoate is acidimetry, non-aqueous direct titration.
A.
B.
C.
D.
E.
What titrant in this method?
Silver nitrate
Sodium thiosulphate
Potassium bromate
Chloride acid
*Perchloric acid
49.
What formed at interaction sodium salicylate with chloride acid?
A.
B.
C.
D.
Pyrocatechol
Phenol
Benzoic acid
Toluene
E.
*Salicylic acid
50.
For identification of benzoic acid the chemist-analyst can uses reaction with:
A.
B.
C.
Potassium hydroxyde
Wine acid
Sodium carbonate
D.
E.
Perchloric acid
*Silver nitrate
51.
For identification of salicylic acid the chemist-analyst can uses reaction with:
A.
Perchloric acid
B.
C.
D.
E.
Potassium hydroxyde
Wine acid
Sodium carbonate
*Iron (ІІІ) chloride
52.
For identification of Sodium ions in sodium benzoate the chemist-analyst used pyrochemical reaction. What colour of flame he observed?
A.
B.
C.
White
Green
Yellow

D.
E.
Violet
*Brown
53.
Under the description salicylic acid represents:
A.
White, crystalline powder or small, colourless crystals or shiny flakes
B.
C.
D.
Amorphous substance of yellow colour with specific smell
White, crystalline or granular powder or flakes
White, crystalline powder or colourless crystals, odourless or with a very slight
E.
characteristic odour
*White, crystalline powder or white or colourless, acicular crystals
54.
The initial substance for synthesis of benzoic acid is:
A.
Pyrocatechol
B.
C.
D.
E.
Benzoic acid
Salicylic acid
Phenol
*Toluene
55.
The chemical name of sodium salicylate:
A.
Sodium benzenecarboxylate
B.
C.
D.
E.
Benzenecarboxylic acid
2-Hydroxybenzenecarboxylic acid
Oxybenzene
*2-Hydroxybenzenecarboxylate
56.
In the medical practice salicylic acid use as means:
A.
B.
C.
D.
E.
57.
What indicator must be used, according to Pharmacopoeia, for assay of sodium benzoate in the method of acidimetry, non-aqueous direct titration?
A.
B.
C.
D.
E.
Purgative
Anti-inflammatory; analgesic
Expectorant
Antimicrobial preservative
*Keratolytic
Methyl orange
Phenolphthalein
Naphtholbenzein solution
Phenol red solution
*Determining the end-point potentiometrically
58.
What pharmacopoeial method of assay for sodium benzoate?
A.
B.
C.
D.
Alkalimetry, back titration
Acidimetry, non-aqueous back titration
Argentometry
Alkalimetry in alcoholic solution, direct titration
E.
*Acidimetry, non-aqueous direct titration
59.
For identification of salicylic acid the chemist-analyst makes reaction formation of aurin dye. He must used such reagents:
A.
B.
Potassium hydroxide and silver nitrate
Iron (ІІІ) chloride and bromine water
C.
D.
Solution of sodium carbonate and chloride acid
Perchloric acid and nitric acid
E.
*Solution of formaldehyde in sulphatic acid concentrated
60.
At decarboxylation of salicylic acid (heating above 160°C with sodium carbonate) is formed:
A.
B.
C.
D.
Pyrocatechol
Toluene
Benzoic acid
Sodium salicylate
E.
*Phenol
61.
For identification of sodium benzoate acid the chemist-analyst can uses reaction with:
A.
B.
C.
Wine acid
Potassium hydroxyde
Sodium carbonate

D.
E.
Perchloric acid
*Iron (ІІІ) chloride
62.
For identification of ions of Sodium in sodium benzoate the chemist-analyst can use reaction with:
A.
Potassium hydroxyde
B.
C.
D.
E.
*Potassium hexahydroxostibat
63.
Under the description the benzoic acid is:
A.
B.
C.
D.
E.
Iron (ІІІ) chloride
Silver nitrate
Wine acid
Colourless liquid
Amorphous substance of yellow colour with specific smell
Colourless crystalline powder, acicular crystals
White, crystalline or granular powder or flakes
*White, crystalline powder or colourless crystals, odourless or with a very slight characteristic odour
64.
The initial substance for synthesis of sodium salicylate is:
A.
Pyrocatechol
B.
C.
D.
E.
Toluene
Benzoic acid
Phenol
*Salicylic acid
65.
The chemical name of sodium benzoate is:
A.
B.
C.
D.
E.
Oxybenzene
2-Hydroxybenzenecarboxylate
Benzenecarboxylic acid
2-Hydroxybenzenecarboxylic acid
*Sodium benzenecarboxylate
66.
In the medical practice sodium salicylate use as means:
A.
B.
C.
D.
Purgative
Keratolytic
Expectorant
Antimicrobial preservative
E.
*Anti-inflammatory; analgesic
67.
The molar weight of equivalent (Em) at assay of benzoic acid by means of alkalimetry in alcoholic solution equals:
A.
М m./3
B.
М m./4
C.
D.
E.
2М. M.
М m./2
*М m.
68.
The pharmacopoeial method of assay for sodium salicylate is acidimetry, non-aqueous direct titration. What titrant in this method?
A.
B.
Silver nitrate
Sodium thiosulphate
C.
D.
Potassium bromate
Chloride acid
E.
*Perchloric acid
69.
For identification of benzoic acid the chemist-analyst used solution of silver nitrate. What colour of
A.
B.
C.
D.
E.
formed precipitate he observed?
Brown
Green
Yellow
Violet
*White
70.
What formed at interaction of sodium benzoate with chloride acid:
A.
B.
Pyrocatechol
Toluene

C.
D.
Sodium salicylate
Phenol
E.
*Benzoic acid
71.
For identification of sodium salicylate acid the chemist-analyst can uses reaction with:
A.
B.
C.
Potassium hydroxyde
Wine acid
Sodium carbonate
D.
E.
Perchloric acid
*Iron (ІІІ) chloride
72.
For identification of ions of Sodium in sodium salicylate the chemist-analyst can use reaction with:
A.
Iron (ІІІ) chloride
B.
C.
D.
E.
Potassium hydroxyde
Silver nitrate
Wine acid
*Methoxyphenylacetic acid reagent
73.
Under the description sodium benzoate represents:
A.
Grey crystalline powder
B.
C.
D.
E.
Amorphous substance of yellow colour with specific smell
Red crystalline powder, acicular crystals
Blue crystalline powder, odourless or with a very slight characteristic odour
*White, crystalline or granular powder or flakes
74.
The initial substance for synthesis of salicylic acid is:
A.
B.
C.
D.
E.
Pyrogalol
Toluene
Benzoic acid
Resorcinol
*Phenol
75.
The chemical name of benzoic acid:
A.
B.
C.
D.
Oxybenzene
2-Hydroxybenzenecarboxylate
2-Hydroxybenzenecarboxylic acid
Sodium benzenecarboxylate
E.
*Benzenecarboxylic acid
76.
For identification of xeroform the chemist-analyst can use reaction with:
A.
B.
C.
Barium sulphate
Tartaric acid
D.
E.
Silver nitrate
Chloroform in the alkaline medium
*Solution of sodium sulphide in chloride-acid medium
77.
The molar weight of equivalent (Em) at assay of thymol (by means of bromatometry, direct titration) equals:
A.
М m.
B.
М m./3
C.
D.
E.
2М. M.
М m./2
*М m./4
78.
In medical to practice phenol use as means:
A.
Antiseptic, disinfectant and vermicidal agent
B.
C.
D.
E.
Keratolytic.
Astringent, drying and antiseptic
Antiseptic, drying, expectorant
*Antiseptic; antimicrobial preservative; antipruritic
79.
For identification of resorcinol, according to Pharmacopoeia, expert of Quality Department of the pharmaceutical enterprise uses reaction with solution:
A.
B.
C.
Calcium chloride
Copper sulphate in the alkaline medium
Sulphate barium

D.
E.
Silver nitrate in the acid medium
*Potassium hydrogen phthalate in the alkaline medium
80.
For assay of phenol the chemist-analyst uses a method of bromatometry, back titration with iodometric finishing. What indicator he used:
A.
B.
C.
Methyl orange
Tropeolin 00
Methyl red
D.
E.
Phenolphthalein
*Solution of starch
81.
The chemical name of xeroform:
A.
Oxybenzene
B.
C.
D.
E.
Dihydroxybenzene
3-Methyl-5-methylphenol
5-Methyl-2-(methylethyl)phenol
*Bismuth tribromophenol basic with bismuth oxide
82.
For synthesis of thymol it is possible to use such initial substance:
A.
Phenylsalicylate
B.
C.
D.
E.
Phthalic acid
Benzol
Phenol
*3-Metylphenol (m-cresol)
83.
For assay of resorcinol, according to Pharmacopoeia, use method:
A.
B.
C.
D.
E.
Cerymetry, direct titration
Iodometry, direct titration
Chelatometry, back titration
Bromatometry, direct titration
*Bromathometry, back titration with iodometric finishing
84.
According to Pharmacopoeia, the resorcinol is:
A.
B.
C.
D.
E.
Amorphous substance of yellow colour with specific smell
Colourless crystals
Colourless or faintly pink or faintly yellowish crystals or crystalline masses
Crystalline powder of yellow colour
*Colourless or slightly pinkish-grey, crystalline powder or crystals, turning red on exposure to light and air
85.
What titrant you must use for assay of xeroform in the chelatometry, direct titration?
A.
B.
C.
D.
Sodium thiosulphate
Potassium bromate
Chloride acid
Silver nitrate
E.
*Sodium EDTA
86.
Pharmacopoeial method of assay for phenol is bromathometry, back titration with iodometric finishing. What titrant you must add in buret?
A.
B.
Potassium bromide
Potassium bromate
C.
D.
Silver nitrate
Chloride acid
E.
*Sodium thiosulphate
87.
For identification of resorcinol the chemist-analyst can use reaction with:
A.
B.
C.
D.
Copper chloride
Barium sulphate
Tartaric acid
Silver nitrate
E.
*Chloroform in the alkaline medium
88.
Under the description phenol represents:
A.
B.
C.
Colourless crystals
Amorphous substance of yellow colour with specific smell
Colourless or slightly pinkish-grey, crystalline powder or crystals, turning red on exposure

D.
to light and air
Crystalline powder of yellow colour
E.
*Colourless or faintly pink or faintly yellowish crystals or crystalline masses
89.
For synthesis of thymol it is possible to use such initial substance:
A.
B.
C.
D.
E.
Phenylsalicylate
Phthalic acid
Benzol
Phenol
*m-Cresol
90.
The molar weight of equivalent (Em) at assay (chelatometry) of xeroform equals:
A.
М m.
B.
C.
М m./3
М m./4
D.
E.
2М. M.
*М m./2
91.
In the medical to practice xeroformium use as means:
A.
Antiseptic, disinfectant and vermicidal agent
B.
C.
D.
E.
Keratolytic
Antiseptic; antimicrobial preservative; antipruritic
Antiseptic, drying, expectorant
*Astringent, drying and antiseptic
92.
The chemical name of thymol:
A.
B.
C.
D.
E.
Oxybenzene m-Dihydroxybenzene
Bismuth tribromophenol basic with bismuth oxide
3-Methyl-5-methylphenol
*5-Methyl-2-(methylethyl)phenol
93.
For identification of phenolic hydroxyl, as chemical component structure of many drugs, can be used reaction with:
A.
B.
C.
D.
E.
Phenylhydrazine
Chloride acid
Ninhydrin
Nitric acid
*Lime chloride or bromine water in the presence of ammonia
94.
The bromatometric definition of the phenols derivatives (phenol, resorcinol, etc.) is based on reaction:
A.
Reduction
Elimination B.
C.
D.
E.
Addition
Oxydation
*Substitution
95.
In the control-analytical laboratory makes limit tests for pyrocatechol in the resorcinol. To solution S
(water solution of resorcinol) add solution of (NH4)2MoO4 and shake up. What analytical effect of reaction?
A.
B.
C.
D.
E.
Green
Red
Blue
White
*Yellow
Ag
N
SO
2
N
96.
The structural formula corresponds to a drug:
A.
Sulfadimethoxine
Sulfathiazole B.
C.
D.
Salazodimethoxine
*Silver sulfadiazine
H
2
N
N

E.
Sulfacetamide sodium
97.
A.
B.
C.
D.
E.
The structural formula corresponds to a drug:
Sulfathiazole
Sulfaguanidine
Salazodimethoxine
Phthalylsulfathiazole
*Sulfapyridazine
H
2
N
98.
The structural formula corresponds to a drug:
A.
Sulfadimethoxine
Sulfathiazole B.
C.
D.
E.
Sulfacetamide sodium
Salazodimethoxine
*Sulfathiazole sodium
H
2
N
OH
HOOC
SO
2
Í
N
N N
OCH
3
Na N
SO
2
N
S
N
N SO
2
H
N
N
OCH
3
N
OCH
3
99.
A.
B.
C.
D.
E.
The structural formula corresponds to a drug:
Sulfathiazole
Sulfadimethoxine
*Salazodimethoxine
Sulfadimethoxine
Phthalylsulfathiazole
O
C HN
COOH
SO
2
H
N
N
S
100.
The structural formula corresponds to a drug:
A.
Sulfadimezine
Sulfaguanidine B.
C.
D.
Sulfadimethoxine
Sulfanilamidopyrimidine
E.
*Phthalylsulfathiazole
OCH
3
H
2
N SO
2
H
N
N
N
101.
102.
The structural formulacorresponds to a drug:
A.
B.
C.
D.
E.
Sulfaguanidine
*Sulfadimethoxine
Sulfanilamidopyrimidine
Sulfathiazole
Sulfacetamide sodium
OCH
3
Pyridine cycle in a molecule of nikethamide it is possible to identify by means of such reagents:
A.
*2,4-dinitrochlorbenzole, ethanol, sodium hydroxide solution
B.
C.
Silver nitrate, nitric acid
Ethylacetic ether, benzene

D.
E.
Methoxiphenylacetatic acid, tetramethylammonium hidroxyde
Zinc chloride, sulphatic acid
H
SO
2
N
103.
The structural formula corresponds to a drug:
A.
B.
C.
D.
E.
Sulfathiazole
Sulfadimethoxine
*Sulfanilamidopyrimidine
Sulfadimezine
Sulfacarbamide
H
2
N
N
N
N
SO
2
N
H
104.
105.
The structural formula corresponds to a drug:
A.
*Sulfathiazole
B.
C.
Sulfaguanidine
Streptocide
D.
E.
Sulfadimezine
Sulfacarbamide
The structural formulacorresponds to a
O
H
2
N
SO
2
NH C NH
2
.
H
2
O
H
2
N drug:
A.
B.
C.
D.
E.
Sulfathiazole
Sulfaguanidine
Streptocide
Sulfadimezine
*Sulfacarbamide
SO
2
N
H
NH
C NH
2
.
H
2
O
106.
The structural formulacorresponds to a drug:
A.
Sulfathiazole
B.
C.
*Sulfaguanidine
Streptocide
D.
E.
Sulfadimezine
Phthalazole
H
2
N
S
SO
2
N
Na
O
C
CH
3
.
H
2
O
107.
The structural formula corresponds to a drug:
A.
B.
Sulfathiazole
*Sulfacetamide sodium
C.
D.
E.
Streptocide soluble
Sulfadimezine
Phthalazole
H
2
N
108.
The structural formula corresponds to a drug:
A.
Sulfathiazole
B.
C.
D.
E.
Sulfaguanidine
*Streptocide soluble
Sulfadimezine
Phthalazole
NaO
3
S C
H
2
N
H
SO
2
NH
2

109.
110.
111.
H
2
N
The structural formula corresponds to a drug:
A.
Sulfathiazole
Sulfaguanidine B.
C.
D.
*Streptocide
Sulfadimezine
E.
Phthalazole
The structural formula corresponds to a
Cl
O O O
C
H
N
H
2
C
H
2
C S
H
N C
O drug:
A.
OCH
3
Chloramine
Carbutamide B.
C.
D.
E.
*Glibenclamide
Chlorpropamide
Tolbutamide
B.
C.
D.
E.
In the medical practice phthivazid use as agent:
A.
Anaesthetic
Helminthicide
Purgative
Expectorant
*Antituberculous
H
N
112.
The structural formula corresponds to a drug:
A.
Chloramine
Chloralhydrate B.
C.
D.
E.
Pantosept
Chlorpropamide
*Tolbutamide
H
3
C
113.
114.
Cl
The structural formula corresponds to a drug:
A.
B.
C.
D.
E.
Chloramine
Chloralhydrate
Pantosept
*Chlorpropamide
Tolbutamide
O
The structural formula corresponds to a drug: HO
A.
Chloramine
Chloralhydrate B.
C.
D.
E.
*Pantosept
Ibuprofen
Toluene
C
SO
2
NH
2
SO
2
NH C
O
N
H
C
4
H
9
SO
2
NH C
O
Cl
SO
2
N
Cl
NH C
3
H
7

O
S
ONa
NCl
.
3H
2
O
115.
A.
B.
C.
D.
E.
The structural formula corresponds to a drug:
*Chloramine
Chloralhydrate
Pantosept
Ibuprofen
Toluene
CH
3
H
2
C
Cl
C
O
ONa
HN
116.
B.
C.
D.
E.
The structural formula corresponds to a drug:
A.
*Diclofenac sodium
Anthranilic acid
Mefenamic acid
Sodium salicylate
Sodium benzoate
Cl
O
C
OH
N
H
117.
118.
119.
B.
C.
D.
E.
The structural formula corresponds to a drug:
A.
Anthranilic acid
*Mefenamic acid
2-Amonobenzoic acid
Lidocaine
Benzocaine
H
3
C
The structural formula corresponds to a drug:
H
3
C
CH C
H
2
A.
B.
C.
D.
E.
Diclofenac sodium
Mefenamic acid o-Amonobenzoic acid
*Ibuprofen
Articaine hydrochloride
H
3
C
H
3
C N
H
O
O
C
C
S
The structural formula corresponds to a drug:
O
CH
CH
3
3
H
C
CH
3
CH
3
C
H
N
H
C
O
OH
C
3
H
7
.
HCl

A.
B.
C.
D.
E.
Procainamide hydrochloride
*Articaine hydrochloride
Tetracaine hydrochloride
Benzocaine
Procaine hydrochloride
CH
3
H
3
C
HN C
O
CH
3
C
H
2
N
C
2
H
5
.
HCl
C
2
H
5
120.
The structural formula corresponds to a drug:
A.
B.
Lidocaine hydrochloride
Articaine hydrochloride
C.
D.
E.
Tetracaine hydrochloride
*Trimecaine hydrochloride
Procaine hydrochloride
CH
3
121.
122.
123.
A.
B.
C.
D.
E.
The structural formula corresponds to a drug:
A.
*Lidocaine hydrochloride
B.
C.
Articaine hydrochloride
Tetracaine hydrochloride
D.
E.
Benzocaine
Procaine hydrochloride
The structural formula corresponds to a drug:
O
C
2
H
5
H
2
N C N
H
C
H
2
C
H
2
N
C
2
H
5
A.
B.
C.
D.
E.
*Procainamide hydrochloride
Articaine hydrochloride
Tetracaine hydrochloride
Benzocaine
Procaine hydrochloride
The structural formula corresponds to a drug:
O
.
CH
3
C
4
H
9
N
H
C O C
H
2
C
H
2
N
CH
3
Procainamide hydrochloride
Articaine hydrochloride
*Tetracaine hydrochloride
Benzocaine
Procaine hydrochloride
.
CH
3
HCl
HCl
H
2
N
N
H
O
C C
H
2
N
C
2
H
5
.
C
2
H
5
HCl
C
O
O
H
2
C
H
2
C N
C
2
H
5
C
2
H
5
*HCl
124.
The structural formulacorresponds to a drug:
A.
B.
C.
Procainamide hydrochloride
Articaine hydrochloride
Tetracaine hydrochloride

D.
E.
Benzocaine
*Procaine hydrochloride
125.
The structural formula corresponds to a drug:
A.
B.
Mefenamic acid
Ibuprofen
C.
D.
E.
Trimecaine hydrochloride
*Benzocaine
Procaine hydrochloride
H
2
N C
O
O C
2
H
5
126.
127.
128.
129.
130.
131.
132.
What reaction can be used for identification aromatic cycle in the molecule structure of phthalylsulfathiazole?
A.
Acetylation
Hydration B.
C.
D.
*Halogenation
Reduction
E.
Oxidation
What external indicator can be used for assay of sulfadimezine by means of nitritometry?
A.
B.
C.
D.
E.
Starch solution
Lead paper
*Potassium iodide test paper
Universal litmus paper
Litmus paper
What method of assay can be used for sulfathiazole sodium?
A.
B.
C.
D.
E.
Chelatometry
Cerimetry
*Alkalimetry in the presence of alcohol
Acidimetry in the presence of alcohol
Iodometry
For identification of a primary aromatic amino group, as chemical compound structure of
Sulfametoxazolum (part of Biseptolum), the chemist can used reaction with:
A.
B.
C.
D.
E.
Solution of sodium nitrate, chloride acid
Chloride acid concentrated.
*Solution of sodium nitrite, chloride acid, naphthol alkaline solution
Reagent Zoneshtein
Chloramine or lime chlorine in the presence of ammonia
The pharmacist-analyst makes assay for Trimethoprimum (the part of Biseptolum) by means of
Keldal method. The molecular weight of equivalent (Em) of preparation is:
A.
M. m./3
B.
C.
D.
E.
*M. m./4
M.m.
M.m./2
M. m./6
The products of acid hydrolysis for sulfacetamide sodium is:
A.
B.
C.
D.
E.
p-Aminotoluene, urea, sodium carbonate p-Aminobenzene, sulfanilic acid, sodium
Toluene, sulphatic acid, sodium acetate
Benzene, ammonia, sodium hydroxide
*p-Aminobenzenesulphamide, sodium hydrosulphate
The specific impurity in the preparation of streptocide soluble is:
A.
B.
C.
D.
E.
Potassium sulphate
*Sodium sulphite
Hlorides
Sulfate ashes
Heavy metals

133.
134.
135.
136.
Presence of Sulfur in the sulfamide group of salazodimethoxine define after its previous:
A.
B.
C.
D.
Decomposition
Esterification
Alkalis hydrolysis
Acid hydrolysis
E.
*Melting with КNO
3
Action and use of sulfadimethoxine is:
A.
B.
C.
D.
E.
Antibacterial incontinuous action
*Antibacterial with long action
Anaesthetic
Antypiretic
Antiseptic
The pharmacist-analyst makes identification of substance salazodimethoxine by means of such reagents:
Bromine water A.
B.
C.
Sodium hydroxide solution, sulphatic acid
Chloramine solution, chloroform
D.
E.
Solution of sodium nitroprusside, sodium hydroxide
*Solution of nitrite sodium, chloride acid, naphthol alkaline solution after preparation hydrolysis
The pharmacological action sulfadimidine is in the:
The big molecular weight A.
B.
C.
D.
E.
*The theory of competitive antagonism
Substance transition in other condition
Principle “phenacetinum”
Principle “salol”
O
C
NH N CH OH
.
H
2
O
137.
138.
139.
140.
141.
OCH
3
The structural formulacorresponds to a drug: N
A.
B.
C.
D.
Flurinizidum
Nicodine
Isoniasid
*Phthivazid
E.
Nikethamide
The pharmacist-analyst used for assay of sulfadimezine iodochlorometry. Molar weight of equivalent (Em) of a preparation is:
A.
B.
C.
D.
M. m./3
M. m.
M.m./2
M. m./6
E.
*M. m./4
Sulfathiazole sodium it is possible to distinguish from sulfathiazole by means of reactions for:
Sulphate-ions A.
B.
C.
Benzene ring
Thiazole cycle
D.
E.
Primary aromatic amino group
*Sodium-ions
Sulfathiazole sodium do not use in the form:
A.
Powder
B.
C.
D.
E.
Injection solutions
Inhalypt
Ophthalmic drops
*Pills
The chemical name of a preparation Sulfathiazole is:

142.
143.
144.
145.
146.
147.
148.
149.
A.
B.
C.
D.
E.
Sodium 2 (p-aminobenzolsulfamide)-thiazole
2 (p-Aminobenzolsulfamide)-pyrimidine
*2 (p-Aminobenzolsulfamide)-thiazole p-Aminobenzene sulfonamide
Sodium p-aminobenzolsulphonylacetamide hydrate
For assay of trimethoprimum (part of Biseptolum) it is possible to use such method:
A.
Iodochlorometry
B.
C.
D.
E.
*Keldal
Iodometry
Gravimetry
Alkalimetry
The chemical name of salazodimethoxine is:
A.
B.
C.
D.
E.
3-Diethylaminomethylamide p-aminobenzoic acid hydrochloride
*5 {p - [(2,4-dimethoxypyrimidinyl-6)-sulfamide]-phenylazo}-salicylic acid
Ethyl ester p-aminobenzoic acid
5 (p - [N - (3-Methoxypyridazinil-6)-sulfamido] phenylazo)-salicylic acid
Diethylamino-2,4,6-trimethylacetanilide hydrochloride
For identification of a primary aromatic amino group, which is included into structure
Sulfametoxazolum (a component of Biseptolum), can be used reaction with such reagent:
A.
B.
C.
D.
E.
Solution of nitrite sodium, chloride acid
Chloride acid
Chloramine in the presence of ammonia
Zonenshtein reagent
*Solution of p-aminobenzaldehyde
The pharmacist-analyst makes assay of salazodimethoxine by means of bromatometry. The molecular weight of equivalent (Em) of preparation is:
A.
M. m./3
B.
C.
D.
E.
*M. m./4
M.m./2
M.m.
M. m./6
The chemical name of salazodimethoxine is:
A.
B.
C.
D.
6-( p-Aminobenzenesulfamide)-1,4- dimethoxypyrimidine
6-( p-Aminobenzenesulfamide)-2,5- dimethoxypyrimidine
5-(p-Aminobenzenesulfamide)-2,4-dimethoxypyrimidine
6-(Benzenesulfamide)-2,4-dimethoxy-pyrimidine
E.
*6-(p-Aminobenzenesulfamide)-2,4-dime-thoxypyrimidine
What functional group is not presence in molecule of sulfadimethoxine?
Pyrimidine cycle A.
B.
C.
D.
E.
Sulfamide group
Methoxy-radical
Primary aromatic amino group
*Alcohol hydroxyl
O
HN
C
2
H
5
O
N
The structural formula corresponds to a drug:
A.
Phenobarbital
B.
C.
D.
E.
Hexenal
Thiopental sodium
*Barbital
Barbamyl
H
The one of initial substances for sulfadimezine synthesis is:
A.
Guanidine
O
C
2
H
5

150.
151.
152.
153.
154.
155.
156.
157.
158.
B.
C.
D.
E.
Acetic acid
*N-Carbomethoxyaniline
Toluene
Resorcinol
For identification of the phthalic acid rest in the molecule of phthalylsulfathiazole it is possible to use reagents:
A.
NaNO
2
, KCl and naphthol solution
B.
Chloramine or lime chlorine, ammonia solution
C.
NaNO
2
, HCl and naphthol solution
D.
E.
*Resorcinol, concentrated H
2
SO
4
, NaOH
NaNO
2
, HCl
What method of assay for sulfathiazole sodium is not possible?
A.
B.
C.
D.
E.
Nitritometry
Keldal
Gravimetry
Acidimetry
*Alkalimetry
The chemical name 4-amino-N-(thiazol-2-yl)benzenesulphonamide is for such sulfanilamide:
A.
B.
C.
D.
Salazodimethoxine
Phthalylsulfathiazole
Sulfadimezine
*Sulfathiazole
E.
Sulfanilamide
The specific impurities are in such preparation:
Sulfathiazole A.
B.
C.
Sulfaquanidine
Sulfadimethoxine
D.
E.
Sulfanilamide
*Phthalylsulfathiazole
Unlike sulfathiazole, sulfathiazole sodium:
A.
Insoluble in water, soluble in alcohol
Soluble in alkalis B.
C.
D.
Soluble in acids and alkalis
Slightly soluble in water and alcohol
E.
*Freely soluble in water
For identification of thiazole cycle in the sulfathiazole the pharmacist-analyst used reaction with such solution:
A.
Sodim nitrite in the medium of HCl
Silver nitrate in the medium of HNO
3
B.
C.
D.
E.
Silver nitrate in the medium of HNO
3
after a preparation mineralization
*Barium chloride in the medium of HCl after a preparation mineralization
Barium chloride in the medium of HCl
For revealing of Sulphur in the sulfaguanidine molecule is necessary oxidizes preparation by means of concentrated HNO
3
. What reagent use for identification of this element?
A.
Copper chloride
B.
C.
D.
E.
*Barium chloride
Sodium hydroxide
Lead acetate
Silver nitrate
Sulfacarbamide is soluble in alkalis because in its molecule is:
A.
Organo-fixed Sulphur
Benzene cycle B.
C.
D.
*Sulfamide group
Aromatic amino group
E.
The urea rest
What reagent is necessary to distinguish sulfacarbamide from others sulfanilamides:
A.
Sulphatic acid

159.
160.
B.
C.
D.
E.
Ammonia solution
*5 % Sodium nitrite solution
Chloride acid
Alkaline solution of naphthol
Sulfaquanidine in medical practice used for treatment:
A.
B.
C.
D.
Tuberculosis
*Intestinal infections
Sharp respiratory diseases
Meningitis
E.
Syphilis
For assay of sulfacetamide sodium can be used such method:
Mercurimetry A.
B.
C.
D.
Permanganatometry
Alkalimetry
Complexometry
161.
162.
163.
164.
165.
166.
167.
E.
*Acidimetry
The chemical name of sulfacarbamide is:
A.
B.
C.
D.
2-(p-Aminobenzenesulfamide)-thiazole p-Aminobenzenesulamide p-Aminobenzenesulfonilacetamide
*p-Aminobenzenesulfonilcarbamide
E.
p-Aminobenzenesulfonilguanidine
The method of assay for barbital is:
Coppermetry A.
B.
C.
Permanganatometry
Ceriumetry
D.
E.
*Alkalimetry, non-aqueous titration
Chelatometry
The chemical name sodium p-sulfamidobenzolamino methylenesulphonate is for preparation:
A.
Sulfanilamide
Sulfathiazole B.
C.
D.
*Streptocide soluble
Phthalylsulfathiazole
E.
Sulfacetamide sodium
Sulfanilamide freely soluble in the:
A.
B.
C.
D.
E.
*Boiling water
Diluted HCl
Alkali
Acetone
Water
What of sulfanilamides has the chemical name - sodium derivative of N-[(4aminophenyl)sulphonyl]acetamide?
A.
Sulfacarbamide
B.
C.
D.
E.
Sulfathiazole
Sulfanilamide
Phthalylsulfathiazole
*Sulfacetamide sodium
The chemist has spent heating of streptocide soluble with the concentrated sulfuric acid in the presence of salicylic acid. What colour the solution will turn out?
A.
Violet
Blue B.
C.
D.
*Crimson
Green
E.
Colourless
The most rational and economical method of synthesis all amides of sulfanilic acid are synthesis from:

168.
169.
170.
171.
172.
173.
174.
175.
176.
A.
B.
C.
D.
E.
*N-carbomethoxyaniline
Urea
Ammonia
Methane
Anthraquinone
The chemist-laboratorian makes pyrochemical reaction for sulfacetamide sodium. What colour of flame he observes?
A.
B.
C.
D.
E.
Green
Pink
Dark blue
Violet
*Yellow
The initial substance for synthesis all amides of sulfanilic acid is:
A.
N-Carbomethoxyaniline
Urea B.
C.
D.
*Sulfanilic acid p-Sulfamidebenzeneaminemethane
E.
Antrahinon
The pharmacist-analyst for assay of sulfacarbamide used nitritometry. Molar weight of equivalent (Em) of preparation is:
A.
M.m./3
M.m./4 B.
C.
D.
E.
*M.m.
M.m./2
M.m./6
At alkaline hydrolysis sulfaguanidine it is allocated:
A.
*Ammonia
B.
C.
D.
E.
Sulphurous gas
Hydrogen sulphide
Carbon dioxide
Aniline
(4-Aminophenylsulphonyl)guanidine is the chemical name of such preparation:
A.
B.
C.
D.
Biseptolum
*Sulfaquanidine
Sulfathiazole
Sulfanilamide
E.
Sulfacarbamide
The urea rest in sulfacarbamide molecule can be defined by means of allocation after pyrolysis:
A.
CO
A.
B.
C.
D.
E.
B.
C.
*NH
3
NO
2
D.
E.
CO
2
H
2
S
The molar weight of an equivalent (Em) of hexenal at assay by means of acidimetry is equal:
3M.m.
M. m./3
M. m./4
*M.m.
M. m./6
The chemist-laboratorian has added to solution of sulfacetamide sodium copper sulphate solution. What analytical effect of reaction he will see?
Red gelatinous precipitate A.
B.
C.
White precipitate
Brown gas
D.
E.
*Precipitate of blue-green colour
White smoke
For assay of sulfanilamide, agrees the AND, can be used such method:

177.
178.
179.
180.
181.
182.
183.
A.
B.
C.
D.
E.
*Nitritometry
Alkalimetry
Cerimetry
Permanganatometry
Gravimetry
The characters of sulfanilamide is:
A.
Yellow crystalline powder, soluble in water
B.
C.
D.
E.
*White or yellowish-white crystals or fine powder, slightly soluble in water
White amorphous powder, soluble in alkalis
White amorphous powder, soluble in acetone
White amorphous powder, soluble in ether
What of drugs is not used as antidiabetic agent:
A.
B.
C.
D.
E.
In the drugstore for realisation go on sale maninil. What chemical compound is the main component this drug?
A.
B.
C.
D.
E.
Glibenclamide
*Pantosept
Chlorpropamide
Tolbutamide
Carbutamide
*Glibenclamide
Pantosept
Carbutamide
Chloranine B
Tolbutamide
O
HN
C
2
H
5
O
N
C
6
H
5
O C O
The structural formula corresponds to a drug:
A.
B.
Barbital
Phenobarbital
C.
D.
Thiopental sodium
Hexenal
C
6
H
5
E.
*Benzonal
The chemical name of chlorpropamide is:
(2RS)-2 [4-methylprophyl) phenyl]-propanoic acid A.
B.
C.
D.
N-(p-methylbenzene-sulphonyl)-N '-butylurea
Sodium N-chlor-4-methylbenzene-sulphoneimide trihydrate
*1-[(4-chlorophenyl)sulphonyl]-3-propylurea
A.
B.
C.
D.
E.
E.
Diethylamino-2,4,6-trimethylacetanilide hydrochloride
The initial substance for synthesis of tolbutamide is:
Benzoic acid
Dimethyaminoethylamine
*Toluene
Benzene
Aniline
The pharmacist-analyst spends assay of tolbutamide by means of alkalimetry in the presence of alcohol. The molecular weight of equivalent (Em) of preparation is equal:
*M m. A.
B.
C.
M. M./2
M. m./4
D.
E.
M.m./6
M. m./3

184.
185.
186.
187.
188.
189.
190.
191.
192.
What reagents use for identification of chloride-ions after mineralization of pantosept?
A.
Reagent of methoxyphenylacetic acid
B.
C.
Ba(NO
3
)
2
solution
BaCl
2
solution
D.
E.
*Solutions of K
2
Cr
2
O
7
, H
2
SO
4
, diphenylcarbazide
K[Sb(OH)
6
] solution
For assay of pantosept can be used method:
A.
B.
C.
D.
E.
*Iodometry
Argentometry
Nitritometry
Gravimetry
Mercurimetry
For identification of chloramine, the pharmacist-analyst has dipped a red litmus paper into a water solution of substance. What thus he observed?
The first red colouring of paper, which then vanished A.
B.
C.
Orange colouring of paper, which passed in red colour
Yellow colouring of paper, which passed in violet colour
D.
E.
Red colouring of paper, which passed in violet colour
*The first dark blue colouring of paper, which then vanished
Under the description chloramine is:
A.
White liquid
*A crystal powder of white or white colour with a yellowish shade B.
C.
D.
E.
Grey weight
Yellow amorphous powder
Colourless crystals
Action and use of carbutamide?
A.
Hypnagogue
B.
C.
D.
E.
Antiseptic
*Antidiabetic (hypoglycemic)
Antipyretic
Local anesthetic
Synonymic (other) name of glibenclamide is:
A.
B.
C.
D.
Butamide
*Maninil
Procainamide hydrochloride
Procaine hydrochloride
E.
Benzocaine
For identification of tolbutamide can be used alkaline hydrolysis of substance. What analytical effect this reaction?
A.
B.
C.
D.
E.
Precipitation of p-toluene sulphonamide
Formation of yellow precipitate
Allocation of carbonic gas
*Fat drops on liquid surface and liberation of gas with a characteristic smell
Precipitate of benzene sulphonic acid
Action and use of tolbutamide?
A.
B.
C.
D.
Antipyretic
*Hypoglycaemic
Expectorant
Antiseptic
E.
Anaesthetic
The pharmacist-analyst spends of assay of chlorpropamide by means of alkalimetry in the presence of alcohol. The molecular weight of equivalent (Em) for chlorpropamide is equal:
A.
B.
C.
D.
E.
M.m./3
M. m./2
M. m./4
M.m./6
*M m.

193.
194.
195.
196.
197.
198.
199.
200.
201.
For Chlorine-ions identification in chlorpropamide molecule it is necessary:
A.
B.
C.
D.
Precipitate of acid hydrolysis product
Makes alkaline hydrolysis of preparation
*Makes mineralization of substance by meams of method of burning with a mix for sintering
Makes dry pyrolysis of substance
E.
Add AgNO
3
solution and HNO
3
The chemist-analyst made pantosept mineralization. What method of assay can be used?
A.
B.
C.
D.
E.
Permanganatometry
Acidimetry
Mercurimetry
Morh
*Keldal
Under the description pantosept is:
A.
White liquid
*White powder with a weak smell of chlorine B.
C.
D.
Grey weight
Yellow amorphous powder
E.
Colourless crystals
The pharmacist-analyst spends assay of chloramine by means of iodometry. As indicator he use:
A.
B.
C.
D.
E.
*Starch solution
Iron-amoniachnye alum
Methyl orange
Phenolphthalein
Methylene dark blue and tropeolin 00
The initial substance for synthesis of chloramine is:
A.
B.
C.
D.
Benzoic acid
Dimethylaminoethylamine p-Aminobenzoyl chloride
*Benzene
E.
Anhydride p-nitrobenzoic acid
What characters of thiopental sodium?
A.
A red solution, without a smell, soluble in water, difficultly soluble in 95 % alcohol,
B.
C.
practically insoluble in ether
Black crystalline powder, sparingly soluble in water, very slightly soluble in alcohol, practically insoluble in methylene chloride
An oily liquid or a crystalline mass, colourless or slightly yellowish, miscible with water and
D.
C.
D.
with alcohol
A blue crystalline powder or colourless crystals, slightly soluble in water, soluble in boiling water and in alcohol
E.
*A yellowish-white powder, hygroscopic, freely soluble in water, partly soluble in ethanol
For assay of trimecaine hydrochloride use argentometry (Volhard method), back titration. As indicator use:
A.
B.
Methyl red
Bromothymol blue
Potassium chromate
Phenolphthalein
E.
*Iron(III) ammonium sulphate
For assay of trimecaine hydrochloride use acidimetry, direct titration. What solvent use for dissolution shot of trimecaine hydrochloride?
A.
B.
C.
D.
E.
Chloroform
*Anhydrous acetic acid
Methanol
Ether
Water
For assay of lidocaine use mercurimetry, direct titration. As titrant use:
A.
B.
Hg
2
Cl
2
HgCl
2

202.
203.
204.
205.
206.
207.
208.
209.
C.
D.
Hg(CH
3
COO)
2
Hg
E.
*Hg(NO
3
)
2
In the nitritometry is not necessary to adhere to such condition:
Slow of titration A.
B.
C.
*Temperature rise
Catalyst presence
D.
E.
Temperature fall
Internal or the external indicator
What analytical functional group can be identified by means of solutions AgNO
3
, HNO
3
,
NH
4
OH?
A.
Ester group
B.
C.
D.
Methyl group
Sodium-ions
*Chloride-ions
E.
Primary aromatic amino group
By means of lignin test it is possible to identify presence in the structure of molecule such functional group:
A.
B.
C.
D.
*Primary aromatic amino group
Carboxylic group
Amide group
Benzene cycle
E.
Ester group
What is the gravimetric form at assay of sodium salt of mefenamic acid?
Mefenamic acid and its salt A.
B.
C.
Sodium cations
*Mefenamic acid
D.
E.
Anthranilic acid
Sodium salt of mefenamic acid
The methods of assay for phthivazid is acidimetry, non-aqueous titration. The molecular weight of equivalent (Em) is:
A.
М m./3
B.
C.
D.
E.
*М m.
3M.m.
М. m./4
2М. m.
O
HN
C
2
H
5
O
HN
C
6
H
5
The structural formula corresponds to a drug:
A.
B.
C.
Barbital
Barbamyl
Thiopental sodium
D.
E.
Hexenal
*Phenobarbital
O
What physical and chemical method of identification use for ibuprofen, according to
Pharmacopoeia?
Polarimetry A.
B.
C.
D.
Refractometry
*IR-spectroscopy
Liquit chromatography
E.
Potentiometry
The chemical name of ibuprofen, according to Pharmacopoeia, is:
A.
3-Dimethylaminoethyl ester p-buthylaminobenzoic acid hydrochloride

210.
211.
212.
213.
214.
215.
216.
217.
218.
B.
C.
D.
E.
Ethyl ester p-aminobenzoic acid
3-Diethylaminoethyl ester p-aminobenzoic acid hydrochloride
Diethylamino-2,4,6-trimethylacetanilide hydrochloride
*(2RS)-2-[4-(2-Methylpropyl)phenyl]propanoic acid
The initial substance for trimecaine hydrochloride synthesis is:
A.
B.
C.
D.
Benzoic acid
2-Dimethylaminoethylamine p-Aminobenzoic acid chloride
*2,4,6-Trimethylaniline
E.
Anhydride p-nitrobenzoic acid
In the medical practice trimecaine hydrochloride use as agent:
*Local anesthetic A.
B.
C.
D.
Antidiabetic
Antipyretic
Expectorant
A.
B.
C.
D.
E.
E.
Antiseptic
What titrant is used for assay of lidocaine by means of Fajans method?
HCl
NaOH
*AgNO
3
NH
4
Fe (SO
4
)
2
NH
4
SCN
The pharmacist-analyst makes assay for lidocaine by means of alkalimetry. What indicator he must use?
*Phenolphthalein A.
B.
C.
Sodium thyosulphate
Methylene dark blue
D.
E.
Tropeolin 00
Starch
For identification of Sodium cations in the diclofenac sodium the chemist add methoxyphenylacetic acid reagent. This reagent consist of such reagents:
Acetic acid and methoxyphenol A.
B.
C.
Methoxyphenylacetic acid and water
*Methoxyphenylacetic acid and tetramethylammonium hydroxide
D.
E.
Methanol and acetic acid
Methoxyphenylacetic acid
For assay of trimecaine hydrochloride use argentometry (Fajans method), direct titration. As indicator use:
Methyl red A.
B.
C.
D.
Iron(III)-ammonium sulphate
Potassium chromate
Phenolphthalein
E.
*Bromothymol blue
Barbamyl is derivative of:
A.
B.
C.
D.
E.
Benzoic acid
*Barbituric acid
Salicylic acid
Salicylic acid
Nicotinic acid
What titrant is used for assay of lidocaine by means of Volhard method?
A.
HCl
B.
C.
D.
E.
*NH
4
SCN
AgNO
3
NH
4
Fe (SO
4
) 2
NaOH
The pharmacist-analyst makes assay for ibuprofen by means of alkalimetry, direct titration at presence:

219.
220.
221.
222.
223.
224.
225.
226.
A.
B.
C.
D.
E.
Hexane
Acetone
Chloroform
Anhydrous acetic acid
*Methanol
What reagents the pharmacist-analyst used for identification primary aromatic amino group in the lidocaine, after alkaline hydrolysis?
A.
B.
C.
D.
E.
Mix of acids and naphthol
Alkaline solution of naphthol
*NaNO
2
, HCl, naphthol alkaline solution
KNO
2
, HCl, naphthol acid solution
NaNO
3
, HCl, naphthol neutral solution
What reaction use for identification ester group in the structure of molecule?
A.
*Formation of salts hydroxamic acids
Decarboxylation B.
C.
D.
Neutralization
Complex formation
E.
Formation of Schiff base
For identification of cations in the molecule of sodium diclofenac, according to Pharmacopoeia, is necessary to use reaction with:
A.
Glyoxalhydroxyanil
Feling reagent B.
C.
D.
E.
Barium sulphate in the medium of H2SO4
*Potassium hexahydroxostibat
Silver nitrate in the medium of HNO3
Mefenamic acid use in medical practice as agent:
A.
Antiarrhytmic, resolvent
B.
C.
D.
E.
Disinfectant, anaesthetic
*Analgesic, resolvent
Antituberculosis, antiseptic
Antidiabetic, antipyretic
Assay of sodium diclofenac makes by means of method:
A.
B.
C.
D.
*Acidimetry, non-aqueous titration
Argentometry, direct titration
Gravimetry
Alkalimetry in non-aqueous titration
E.
Alkalimetry in the water medium
What is equivalent weight (Em) of ibuprofen at quantitative definition by means of alkalimetry its methanol solution?
A.
М m./16
B.
C.
D.
М m./8
М m./5
2 М m
E.
*М m.
The physical and chemical method for identification of ibuprofen is:
A.
B.
C.
D.
Polarimetry
Refractometry
*UV-spectroscopy
Solution chromatography
E.
Potentiometry
Presence in the molecule structure of trimecaine hydrochloride amide group can be defined by means of such reaction:
A.
B.
C.
D.
E.
Acid or alkaline hydrolysis with the subsequent identification of hydrolysis products
Esterification
Polymerisation
Combination reaction
*Acid hydrolysis

227.
228.
229.
230.
231.
232.
233.
234.
235.
The chemical name of trimecaine hydrochloride is:
A.
B.
C.
D.
Diethylaminomethylamide p-aminobenzoic acid hydrochloride
Dimethylaminoethyl ester of p-buthylaminobenzoic acid hydrochloride
Ethyl ester p-aminobenzoic acids
Diethylaminoethyl ester of p-aminobenzoic acid hydrochloride
E.
*Diethylamino-2,4,6-trimethylacetanilide hydrochloride
What drug is used as local anesthetic:
A.
B.
C.
D.
E.
Resorcinol
*Lidocaine
Sodium benzoate
Phenyl salicylate
Acetylsalicylic acid
The method of assay for lidocaine is nitritometry after the previous hydrolysis. What external indicator can be used?
Iodide paper A.
B.
C.
Phenolphthalein paper
Starch paper
D.
E.
Litmus paper
*Potassium iodide test paper
For identification of ester group as chemical component of structure of preparation, can be used such reaction:
Indophenol test A.
B.
C.
D.
Decolouration of bromine water
Diazotization
*Alkaline hydrolysis at heating
E.
Lignin test
For distinguishing tetracaine hydrochloride from benzocaine it is possible to use reaction with:
A.
B.
C.
D.
E.
Alkaline solution of naphthole
Bromic water
Alkali at presence hydroxylamine
Sodium nitrite in the presence of HCl
*Silver nitrate in the medium of HNO3
The pharmacist-analyst spends assay of procainamide hydrochloride by means of argentometry
(Volhard method). As indicator he used:
A.
B.
C.
D.
E.
Methylene dark blue and tropeolin 00
*Ammonium iron alum
Methyl orange
Phenolphthaleine
Potassium iodide test paper
For identification of a primary aromatic amino group in procainamide hydrochloride, the chemist has spent reaction with:
Ketones A.
B.
C.
Carboxylic acids
Aliphatic aldehydes
D.
E.
*Aromatic aldehydes
Aromatic acids
Hexenal use in medical practice as agent:
A.
Picoline
Sedative of short term action B.
C.
D.
E.
*Purgative
For an inhalation narcosis
Sedative of long action
For assay of procaine hydrochloride can be used nitritometry. As indicator use:
A.
*Mix of tropeolin 00 and methylene dark blue
B.
C.
D.
Phenolphthaleine
Bromphenol dark blue
Litmus paper

236.
237.
238.
239.
240.
241.
242.
243.
244.
E.
Methyl orange
Procaine hydrochloride do not use in the such medicinal form:
A.
B.
C.
D.
E.
Ointment
*Aerosol
Injection solution
Suppositories
Tablets
What reagents for identification Chloride-ions in the articaine hydrochloride?
A.
B.
C.
D.
MgSO
4
, BaCl
2
8-Oxyquinoline, (NH
4
)
2
C
2
O
4 m-Dinitrobenzene, Feling reagent
*AgNO
3
, HNO
3
, NH
4
OH
E.
NaNO
2
, HCl, naphthol
The chemical name of drug is 2-diethylaminoethyl-4-aminobenzoate hydrochloride. What this drug?
A.
B.
C.
D.
Articaine hydrochloride
Benzocaine
Procainamide hydrochloride
Tetracaine hydrochloride
E.
*Procaine hydrochloride
Procaine hydrochloride is the competitor of streptocide, because in an organism its hydrolysed with formation:
A.
B.
C.
D.
E.
Sulfanilic acid
Ethanol
Diethylaminoethanole o-Aminobenzoic acid
*p-Aminobenzoic acid
The characteristic reaction for benzene cycle is interaction with:
A.
B.
C.
D.
Sodium hydroxyde at heating
*Bromic water
Sodium nitrite in the acid medium
Potassium dichromate
E.
Sodium hydroxyde and hydroxylamine
The pharmacist-analyst makes assay of procainamide hydrochloride by means of nitritometry.
The molecular weight of equivalent (Em) of preparation is:
A.
B.
C.
D.
M.m./3
M.m./4
M.m./2
*M.m.
E.
M.m./6
The pharmacist-analyst makes identification of procainamide hydrochloride. Thus he can used such reagents:
A.
B.
C.
D.
Solution of potassium chromate, diphenylcarbazone
Solution of sodium hydroxyde, sulphatic acid
Solution of nitrate sodium, nitric acid
Solution of sodium hydroxyde, chloroform
E.
*Solution of nitrite sodium, chloride acid, naphthol alkaline solution
Under the description tetracaine hydrochloride is:
Colourless liquid with a pungent smell A.
B.
C.
D.
White amorphous powder with a characteristic smell
Oily liquid without a smell
Yellow crystal powder with a characteristic smell
E.
*White crystal powder without a smell
Presence ester group in structure of tetracaine hydrochloride molecule can be confirmed by means of reaction:
A.
B.
*Formation of hydroxamic acids salts
Decarboxylation

245.
246.
247.
248.
C.
D.
D.
E.
Neutralization
Complex formation
E.
Formation of Schiff base
Procaine hydrochloride use as agent:
Resolvent A.
B.
C.
Helminthicide
Expectorant
Antiallergenic
*Local anesthetic, the competitor of streptocide
For assay of procaine hydrochloride it is possible to use argentometry (Morh method). The essence of this method is:
A.
B.
Titration with AgNO3 in the presence of NH3
*Direct titration with solution AgNO3 in the presence of indicator K2CrO4 to occurrence of orange-red precipitate
C.
D.
E.
Back titration with solution AgNO3
Direct titration with solution NH4SCN at presence ammonium iron alum
Titration of excess AgNO3 by means of standard solution NH4SCN at presence ammonium iron alum
The initial substance for benzocaine synthesis is:
A.
B.
C.
D.
E.
Benzene
Phenol
*Toluene
Benzocaine
Novocaine
As local anesthetic use:
A.
B.
C.
D.
E.
Vanillin
Salicylic acid
Thymol
*Articaine hydrochloride
Resorcinol