Lê Đình Thao 1, Nguyễn Thúy Hạnh 1 , Đoàn Thị Thanh 1 , Phạm Ngọc Dung 1 , Nguyễn Hồng Tuyên 1 , Lê Thị Thanh Tâm 1 , Lê Thị Phương Thảo 1, Hoàng Thị Hoài 1 , Trần Ngọc Khánh 1 ABSTRACT Experiments of bio-product BS2 for controlling late blight disease on tomato Plant-pathogenic fungi and bacteria can be affected by fungal and bacterial antagonists such a naturally occurring interference between beneficial microorganisms and plant pathogens that contributes to the natural buffering of cropping systems, thus preventing or limiting disease spread. Biological control offers an environmentally friendly alternative to the use of fungicides for controlling plant diseases. Bio-product BS2 was produced from Bacillus amyloliquefaciens and Streptomyces toxytricini which are used in IPM programmes as a biocontrol agent to control late blight disease of tomato caused by Phytophthora infestans. The population of the pathogen was reduced by 77.61% as a result, leading to an increase in a famer’s income (tomato yield increased by 16.69%). Key words:Bacillus amyloliquefaciens, Streptomyces toxytricini, Phytophthora infestans, Bio-product.