Peripheral vascular disease-2015 /16
Intermittent claudication = ischaemic pain due to decompensation of the blood supply
typically occurring with physical activity.
. Most common- distal superficial femoral artery (located just above the knee joint),
= claudication in the calf muscles
. If proximal vessels involved - symptoms in thighs and buttocks, ED.
PAD affects 20% of people >60years age & usually about 60% of affected will be
asymptomatic.
Of those with intermittent claudication, over 5 years:
- 70–80% will remain with stable claudication
- 10–20% will get worsening claudication symptoms
- 5–10% will develop critical limb ischaemia
Of those who develop critical limb ischaemia 33% will require a major amputation within
the next 12 months.
But Cardiovascular disease is the biggest concern
Of those with intermittent claudication:
 10–15% will die from a CV event within 5yrs
 A further 20% will have a non-fatal CV event over those 5yrs.
Of those who develop critical ischaemia, 25% will die from cardiovascular disease
in the next 12months (So prognosis similar to many cancers!). The Edinburgh
Artery Study has shown that even a near-normal ABPI (0.9-1.0) is associated with
reduced 5 year survival.
Up to 20% of symptomatic may be diabetic so important to screen for DM.
Mechanisms
•
Atherosclerosis
.Vasospasm . Inflammation/ vasculitis .Thrombosis/ Embolism
The Fontaine Classification:
• Stage I asymptomatic
• Stage II intermittent claudication
• Stage III rest pain / nocturnal pain
• Stage IV necrosis / gangrene
Assessment:
History= likelihood ratio of positive diagnosis 4.8
Inspection - Gait, colour, hair, temperature, muscle bulk, toenails, ulcers etc.
Palpation- Aortic aneurysm. Cool skin in those with positive history has LR of 5.9
BP- not because you are going to dx something but because you want to control BP
as a CVD risk factor.
 Pulses (Abnormality has LR of 3.1) Normal pulses reduce chance of PAD but don’t
exclude it.
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Auscultation- Renal, femoral and carotid bruits, Femoral artery bruit has LR of 4.8.
Also you might need to start ACEI.
ABPI in all -See interpretation later on
Think about medication - Certain drugs can also reduce blood flow to the
extremities. These can cause Raynaud's phenomenon. e.g. Oral contraceptives,
Clonidine, Ergotamine, Cyclosporin, Cocaine
Bloods- FBC, HbA1C and non fasting lipid profile, Cr&Es, LFTs( need statins).
But Autoantibodies, Bone profile, Coagulation screen, CRP, Myeloma screen, if
other pathology suspected
Surgical Rx
Rest pain/gangrene – admit or discuss with on call vascular surgeon
IC limiting lifestyle and patient willing to consider operation or angioplasty, then refer
vascular surgery.
Foot ulcer – refer foot ulcer service & consider vascular referral
Others – manage in Primary Care as Endovascular and surgical Rx not recommended in
majority of patients.
Medical Treatment
. Supervised exercise programme; 2 hours per week for 3 months
. Smoking cessation
. Treat with Atorvastatin 80 to target Cholesterol (40mg if on CCBs)
. HTN to target (<150/<90 mmHg) If BP suboptimal opt for ACEI- According to HOPE
study for reduction by CVD
. Clopidogrel 75mg a day or Aspirin if not tolerated. If both Aspirin and Clopidogrel are
contraindicated then Dipyridamole may be used.
. Naftidrofuryl - vasodilator effects and is licensed for the medical treatment of IC, but has
fair few interactions so beware.
Dose -100 mg TDS initially, increasing to 200 mg TDS.
Consider naftidrofuryl oxalate for treating people with IC if
supervised exercise has not led to satisfactory improvement and
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the person prefers not to be referred for consideration of angioplasty or bypass
surgery.
Review progress after 3-6 months and discontinue naftidrofuryl oxalate if there has been
no symptomatic benefit.
• Nifedipine mentioned for Raynaud’s not proper Peripheral Vasc Disease
• Oxypentifylline, oral prostaglandins not recommended.
ABPI = Ankle systolic pressure/ Brachial systolic pressure.( 2pm Wednesday Allen house,
leg clinic,walk in via DNs)
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In the absence of significant stenosis or occlusion in these vessels the two values
are usually within 10 mmHg of each other even in the presence of more proximal
disease.
The maximum cuff pressure at which the pulse can just be heard with the probe is
recorded .BP measured in both arms and the higher of both used.
Interpretation of values
• Symptom free
- 1 or more
• Intermittent claudication
- 0.95 - 0.5
• Rest pain
- 0.5 - 0.3
• Gangrene and ulceration - <0.2
• The measured ankle cuff pressure may be falsely elevated in patients with calcified
arteries (particularly occurs in diabetic and renal patients). An ABPI of >1.3 has
been suggested as a strong indicator of calcification.
• For ABPI >1 esp diabetics consider Toe-Brachial Index(TBI) done via vascular clinic
if compression bandaging considered. Mainly as high incidence of vascular
calcification.
• In patients with chronic venous ulceration, it is currently recommended that the
ABPI should be >0.8 if compression bandaging is to be applied safely in the
community.
Annual review
Patients, as a result of remembering their annual review date or having a reminder on their
prescription will ring to book their annual review. The reception team will book
appointments with PN/ HCA as per flow charts for investigations.
QOF
QOF
Description
indicator
Points
Threshold Any
changes
from
2014/15
PAD001 Register of people with peripheral
arterial disease
PAD002 Percentage of patients with PAD in
whom the last BP reading
(measured in the preceding 12
months) is ≤150/90
PAD004 Percentage of patients with
peripheral arterial disease with a
record in the preceding 12 months
that aspirin or an alternative antiplatelet is being taken
2
No
2
40-90%
No
2
40-90%
No
References:
SIGN OCT 2006 – Management of PVD
NICE TA210 Dec 2010 – Clopidogrel and PVD
NICE TA223 May 2012 – Naftidrofuryl and PVD
NICE CG 147 August 2012 Lower limb peripheral arterial disease
GP Notebook online handbook 2015
FB presentation 2012.
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