8/16/2011 This packet comprises the Science course descriptions and available syllabi for science courses taken as a requirement or elective for one of the AYA Science programs on ONU’s semester system (beginning Fall, 2011). As some of these courses have not yet been taught, detailed syllabi may not be available. Please refer to the comparable quarter course. Subject Biological Sciences (BIOL) 1031 Life and Earth Sciences for Early and Middle Childhood Education Majors 3 Cr edits Diversity, evolution, ecology, cell biology, inheritance and earth science as they affec t and have affected life on earth. 1201 Introductory Biology 4 Credits An introduction to the concepts underlying the structure and function of cells including their organization, chemical foundations, metabolism, and the principles and mechanisms of heredity and gene expression 1311 Biology 1: Cells and Molecules 4 Credits An introduction to the concepts underlyi ng the structure and function of cells including their organization, chemical foundations, metabolism, and the principles and mechanisms of heredity and gene expression 1321 Biology 2: Organismal Biology 4 Credits Comprehensive integrated study of plant and animal anatomy and physiology focusing on the major systems. Corresp onding inquiry-based laboratories complement the lecture. Prerequisite(s): BIOL 1311. 1341 Human Anatomy and Histology 3 Credits Basic anatomy of human tissues and organ systems at the gross and microscopic levels. Offered spring semester. Prerequisite(s): BIOL 1311 or BIOL 1201. Corequisite(s): BIOL 1361. 1361 Lab for Human Anatomy and Histology 1 Credits Lab for BIOL 1341. Human sy stems studied using cat dissection, radio-graphs, anatomical models and histological slides. Offered spring semester. Prerequisite(s): BIOL 1311 or BIOL 1201. Corequisite(s): BIOL 1341. 1951 Biology Orientation 1 Credit Presentations and discussions relating to adjustment and requirements of academic life within the University, College and the Department of Biological & Allied Health Sciences. Graded S/U. Offered spring semester. 2001 Biology 3: Diversity of Life 4 Credits Investigations of ecological and evolutionary processes, biodiversity, phylogenetic relationships, and paleogeography. Offered fall semester. Prerequisite(s): BIOL 1321 3681 Ichthyology Corequisite(s): BIOL 3661 and BIOL 3671 and BIOL 3691 and BIOL 3701. 3691 Field Invertebrate Biology 3 Credits Field investigations of aquatic and terrestrial invertebrates emphasizing the diversity, ecology, conservation, and methods for their study. Offered fall semester. Corequisite(s): BIOL 3661 and BIOL 3671 and BIOL 3681 and BIO L 3701. 3701 Marine Biology Additional fee is charged. Permission of the instructor required. Offered fall semester. Corequisite(s): BIOL 3661 and BIOL 3671 and BIOL 3681 and BIOL 3691. 3711 Advanced Marine Biology 3 Credits Ecological, physical and chemical aspects of marine systems. Permission of the instructor required. Offered spring semester. 3721 Topics in Marine Biology 1 to 3 Credits Ecological, physical and chemical aspects of marine systems. 8/16/2011 3831 Animal Behavior 3 Credits Invertebrates and vertebrates, stressing observational and descriptive techniques. Offered alternate years. A lab fee is charged. Offered alternate spring semesters. Prerequisite(s): (BIOL 2001). 3971 Self-Directed Studies in the Biological Sciences 1 to 3 A maximum of 3 hours may be counted toward the major. Cannot be used as a general education class. Graded S/U. Formerly BIOL 397. Offered fall and spring semesters. 4231 Topics in Ecology and Biogeography 1 to 3 Credits Current literature on selecte d topics. Permission of instructor. May be repeated for credit as the topics vary. Formerly BIOL 423. 4511 Advanced Topics in Cell Biology 2 Credits Current literature on selected cell biology. May be repeated for credit as the topics vary. Formerly BIOL 451. Offered fall semester. Prerequisite(s): (BIOL 3511 or BIOL 351) and (CHEM 3111 or CHEM 311) or (PHBS 3411) 4631 Clinical Immunology 3 Credits Lecture/laboratory coverage of the structure and function of the human immune system and methods used to diagnose, prognose, and monitor its response in health and disease states. A lab fee is charged. Minimum grade of C for CLS majors. Instructor permission required. Offered summers. 4641 Hematology and Hemostasis 5 Credits Lecture/laboratory coverage of human blood ontogeny, kinetics, pathophysiology, and methods used to diagnose, prognose, and monitor diseases of the blood, blood forming tissues, and disorders of ASBIOL BIOL hemostasis. A lab fee is charged. Minimum grade of C for CLS majors. Instructor permission required. Offered fall semester. 4671 Diagnostic Microbiology 5 Credits Lecture/laboratory coverage of microbes of medical interest, emphasizing application of conventional methods and emerging technologies to isolate, identify, and detect antimicrobial susceptibility of bacteria, viruses, fungi, and parasites associated with human disease. A lab fee is charged. Minimum grade of C for CLS majors. Instructor permission required. Offered summers. 4811 Internship Program 12 Credits Experience enables the student to experience worki ng with scientists in a professional workplace. Only 4 credit hours can be used in the ma jor. Offered fall and spring semesters. Formerly BIOL 481. 4821 Internship in Environm ental Studies 12 Credits Experience working with scientists in a professional workplace. Offered fall and spring semesters. For ENVR majors. Normal grading. Formerly BIOL 482. 4831 Forensic Biology Internship 4 Credits Capstone experience for Forensic Biology m ajor or Biology Major designed for the student to work in a forensic testing laboratory or laboratory approved by the Director of the Forensic Biology. Pre-requisite(s): Biol 3571 minimum grade of C or BIOL 357 minimum grade of C. 4841 Experiential Biology 4 4901 Special Topics in Biological Sciences 1 to 4 Credits Disciplines such as mammal ogy and plant taxonomy. May be repeated for credit as topic varies. Formerly BIOL 490. 4921 -- Capstone Experience 1 Credit Experience (off- campus REU research program, study abroad, internship) must be approved by the Department in the semester prior to enrollment. Offered fall and spring semesters. 4941 Capstone Seminar 1 Credit Oral and written presentations of Capstone Experience. A special fee is assessed. Offered fall and spring semesters. 4971 Independent Research in Biology 1 to 3 8/16/2011 Subject Geology (GEOL) 2801 Geology 3 Credits Physical geology and paleogeology, including chemical properties of minerals and rocks, geologic processes, and earth materials. May be taken without G EOL 2811. Formerly GEOL 280. Offered fall semester. 2811 Geology Lab 1 Techniques used by geologists. A Nature Center use fee is charge d. Offered fall semester. Corequisite(s): GEOL 2801. 2901 Special Topics in Geology 1 to 3 Credits May be repeated for credit up to total of 8 hours as the topic varies. Formerly GEOL 290. Offered fall semester. Prerequisite(s): (GEOL 2801 or GEOL 280). 2971 Independent Study in Geology 1 to 3 Credits Independent study in geology. Permission of instructor. Subject Chemistry (CHEM) 1711 General Chemistry 1 5 Credits Macroscopic concepts of the elements, compounds and reactions. Stoichiometry, thermochemistry and properties of ideal gases as applied to reactive systems. Emphasis on acid-base, redox, and descriptive chemistry. Atomic theory and its application to bonding. Laboratory supports principles presented in lecture, including spectroscopy. High school chemistry required. Offered fall semester. 1721 General Chemistry 2 5 Credits Molecular structure, condensed phases, chemical reactions and mechanisms. Physical principles controlling chemical reactions including kinetics, thermodynamics, electrochemistry, and acid-base equilibrium conditions. Laboratory supports principles presented in lecture, including kinetics and equilibrium. Credit may be received for either CHEM 1721 or CHE M 1821, but not for both. Offered spring semester. Prerequisite(s): CHEM 1711 or CHEM 1811 or CHEM 172 or CHEM 182. 1811 General Chemistry 1 - Majors 5 Credits Macroscopic concepts of the elements, compounds and reactions. Stoichiometry, thermochemistry and properties of ideal gases as applied to reactive systems. Emphasis on acid-base, redox, and descriptive chemistry. Atomic theory and its application to bonding. Laboratory supports principles presented in lecture, including spectroscopy. Credit may be received for only one of the following courses: CHEM 1001, CHEM 1201, CHEM 1501, CHEM 1711, or CHEM 1811. Offered fall semester. 1821 General Chemistry 2 Majors 5 Credits Molecular structure, condensed phases, che mical reactions and mechanisms. Physical principles controlling chemical reactions including kinetics, thermodynamics, electrochemistry, and acid-base equilibrium conditions. Laboratory supports principles presented in lecture, including kinetics and equilibrium. Credit may be received for either CHEM 1721 o r CHEM 1821, but not for both. Offered spring semester. Prerequisite(s): CHEM 1711 or CHEM 1811 or CHEM 172 or CHEM 182. 1901 Special Topics 2001 Capstone 1 1 Credit Methods and objectives of chemical research. Undergraduate research opportunities in the department. Science literature search engines. Summer research opportunities at other institutions. Offered fall 8/16/2011 semester. Prerequisite(s): CHEM 1821 or CHEM 1721 or CHEM 183 or CHEM 173. 2311 Analytical Chemistry 1 4 Credits Practice and principles of modern chemical methods of analysis including instrumental methods. Offered fall semester. Prerequisite(s): CHEM 1721 or CHEM 1821 or CHEM 183 or CHEM 173. 2401 Elements of Physical Chemistry 3 Credits Principles and applications of selected areas of physical chemistry including thermodynamics, kinetics, and spectroscopy. Credit may be received for CHEM 2401 or CHEM 3411 but not for both. Offered alternate spring semesters. Prerequisite(s): CHEM 1501 or CHEM 1721 o r CHEM 1821 or CHEM 183 or CHEM 173 or CHEM 226. 2481 Chemical Applications of Mathematics 3 Credits Application of mathematical techniques to problems in chemistry. Offered spring semester. Prerequisite(s): CHEM 1721 or CHEM 182. 2511 Organic Chemistry 1 3 Credits Bonding, acidity, functional groups, conformations, stereochemistry, nomenclature, fundamental reactions/mechanisms (SN1, SN2 , E1, E2) of organic chemistry, addition reactions to alkenes and alkynes, oxidation and reduction, and structure determination using IR, NMR, etc. 2521 Organic Chemistry 2 3 Credits Reactions with/on radicals, dienes, aromatics, alcoh ols, carbonyls, amines, the structure and chemistry of carbohydrates, 2551 Organic Chemistry Lab 1 1 Credit 2561 Organic Chemistry Lab 2 1 Credit 2611 Organic Chemistry 1 Majors 3 Credits Bonding, acidity, functional groups, conformations, stereochemistry, nomenclature, fundamental reactions/mechanisms (S N1, SN2, E1, E2) of organic chemistry, addition reactions to alkenes and alkynes, oxidatio n and reduction, and structure determination using IR, NMR 2621 Organic Chemistry 2 - Majors 3 Credits Reactions with/on radicals, dienes, aromatics, alcohols, carbonyls, amines, the structure and chemistry of carbohydrate s, and organic 2651 Organic Chemistry Lab 1 - Majors 1 Credit 2661 Organic Chemistry Lab 2 Majors 1 Credit 2971 Independent Study 1 to 4 Credits Can be repeated for a maximum of 4 credit ho urs. 3001 Capstone 2 1 Credit Careers in the chemical/biochemical sciences. 3111 Biochemistry 3 Credits Fundamentals of biochemistry with emphasis on the structu res and properties of the major classes of biological molecules and the relationships betw een biomolecular structure and function; introduction to enzyme catalysis and metabolic pathways. 3151 Biochemistry Lab 1 Credit 3201 Medicinal Chemistry 3 Credits Fundamentals of drug design and drug reaction including SAR, stereochemical considerations, free energy relationships, receptors, enzymes, prodrugs and drug metabolism. Isolation, synthesis, characterization, and biology of bioactive natural products. Offered alternate spring semesters. Prerequisite(s): (CHEM 2521 and CHEM 2561) or (CHEM 2621 and CH EM 2661) or CHEM 253 or CHEM 263. 3261 Medicinal Chemistry Lab 1 Credit Synthesis and characterization of small molecule inhibitors. Fundamentals of a tumor cell assay. SAR using experimental data. Offered alternate spring semesters. Corequisite(s): CHEM 3201. 3411 Physical Chemistry 1 4 Credits Classical thermodynamics. Quantum mechanics of atoms and molecules. Laboratory illustrates principles and applications. Knowledge of computer programming recommended. 8/16/2011 3421 Physical Chemistry 2 4 Credits Molecular structure, statistical thermodynamics, and reaction dynamics. Laboratory illustrates applications in spectroscopy and kinetics. Offered spring semester. Prerequisite(s): CHEM 3411 or CHEM 342. 3601 Organic Synthesis 4 Credits Retrosynthetic analysis, functional group transformations, asymmetric synthesis, organometallic chemistry. 3711 Inorganic Chemistry 1 3 Credits Bonding, structures, preparation, properties, compounds, and reactions of main group and transition metal elements. Laboratory involves basic methods of synthesis and characterization. Offered fall semester. Prerequisite(s): (CHEM 2621 and CHEM 2661) or CHEM 263. 3751 Inorganic Chemistry 1 Lab 1 Credit Lab for CHEM 3711. Offered fall semester. Corequisite(s): CHEM 3711. 3901 Special Topics 1 to 3 Credits 4001 Capstone 3 2 Credits Oral presentation and a formal paper on a chemical topic. Offered spring semester. Prerequisite(s): CHEM 3001 or CHEM 300 . 4111 Advanced Biochemistry: Proteins and Metabolism 3 Credits In depth study of protein structure and function;; enzyme kinetics and mechanisms; regulation and integration of metabolism;; bioenergetics 4161 Advanced Biochemistry Lab 2 321 Analytical Chemistry 2 Principles, design and use of chemical instrumentation. Laboratory stresses independent, investigative experimentation. Can be taken concurrently with CHEM 3421. 4421 Advanced Physical Chemistry 3 Credits Selected topics from group theory, advanced quantum mechanics, spectroscopy and chemical dynamics. Knowledge of computer programming recommended. Can be taken concurrently with CHE M 3421. Offered alternate spring semesters. Prerequisite(s): CHEM 3421 or CHEM 343. 4601 Physical Organic Chemistry 3 Credits Application of molecular orbital theory, thermodynamics, and kinetics to the study of organic reaction mechanisms. Can be taken concurrently with CHEM 3421. Offered alternate spring semesters. 4721 Inorganic Chemistry 2 3 Laboratory involves advanced methods of synthesis and characterization. Can be taken concurrently with CHEM 3421. Offered alternate spring semesters. 4811 Senior Research 1 2 Credits Mentored research project. Offered fall semester. Prerequisite(s): CHEM 3001. 4821 Senior Research 2 2 Credits Mentored research project. Offered spring semester. Prerequisite(s): CHEM 4811. 4901 Special Topics 1 to 3 Credits 4971 Independent Study 1 to 4 Credits Can be repeated for a maximum of 4 credit ho urs. Subject Physics (PHYS) 0001 Orientation 1 Credit Familiarization with the department, requirements for majors, pl anning a program of courses. Required of department majors. Graded S/U. Offered fall s emester. 1001 Conceptual Physics 3 Credits Issues involving science and society, classical physic s, relativity, atomic and nuclear physics. 1051 Planetary Astronomy 3 Credits Introduction to solar system science, history of astronomy, telescopes, basic earth science. 1061 Stars and Galaxies 3 Credits Structure, motions and evolution of stars, 8/16/2011 interstellar material, galaxies and the universe as a whole. 1081 Planetary Astronomy Laboratory 1 Credit 1091 Stars and Galaxies Laboratory 1 Credit 1901 Special Topics in Physics 1 to 3 Credits . 1911 Special Topics in Summer Honors Institute 1 to 3 2051 Physics with Health Science Applications 3 Credits Selected basic physical principles and their application to health science, magnetism, optics, and radiation. 2111 General Physics 1 3 Credits Classic Newtonian mechanics and thermodynamics. 2121 General Physics 2 3 Credits Electrical and magnetic phenomena. Oscillations and sound. Optics. 2311 Physics 1 3 Credits Classic Newtonian mechanics and thermodynamics. Differential and integral calculus are used. 2321 Physics 2 3 Credits Electrical and magnetic phenomena. Oscillations and sound. O ptics. Differential and integral calculus are used. 2341 Physics Laboratory 1 1 Credit or 2311 should be taken concurrently, or instructor’ s permission must be obtained. 2351 Physics Laboratory 2 1 Credit or 2321 should be taken concurrently, or instructor’ s permission must be obtained. 2901 Special Topics in Physics 1 to 3 Credits . 3011 Advanced Physics Lab 2 Credits Statistical analysis of data and error propagation. Linear and nonlinear curve fitting. Design and construction of scientific apparatus. Signal conditioning. Optical techniques. Vacuum systems. 3051 Modern Physics 3 Credits General and special relativity, quantum and wave mechanics, atomic and nuclear physics. 3111 Nuclear Physics 3 Credits Nuclear structure, nuclear reactions, nuclear constituents, fundamentals of nuclear reactor theory and design, shielding and safety principles in nuclear physics. Offered alternate spring semesters. 3411 Optics 3 Credits The laws of geometrical and phsyics options, image formation by mirrors and lenses and optical aberrations. Interference and diffraction. 3451 Math Methods 3 Credits Vector algebra, vector calculus in arbitrary coordinate systems, Fourier analysis, contour integration in complex plane, special functions. 3471 Introductory Astrophysics 3 Credits Motions and physical nature of objects in the solar system, electromagnetic radiation, telescopes and astronomical detector s. 3511 Solid State 3 Credits Structure of solids. Quantum and statistical mechanics are used to develop theories of internal stress and strain in crystals, conductivity of electricity in metals, semiconductors and superconductors, magnetism, the thermal properties of solids and imperfections in solids. 3531 Statistical Mechanics 3 Credits Properties of gases, thermal properties of solids and liquids, thermodynamic laws. Heat transfer. Kinetic thermodynamic laws. 3551 Electronics 3 Credits Theory of solid state devices, rectifier circuits, transistor amplifiers, oscillators and modulators, instrumentation applications. 3571 Computational Physics 3 Credits Methods and problems in computational physics. 3731 Analytical Mechanics 3 Credits Vector analysis, kinematics, conservative forces, pla netary motion, pendulum, free and forced oscillations, coupled systems and normal coordin ates, angular momentum, rigid bodies. Offered alternate fall 8/16/2011 semesters. 3751 Quantum Mechanics 3 Credits Eigenvalues and eigenvectors, commutators, braket notation, postulates of quantum theory, solution of the Schrodinger wave equation for square well potential, harmonic oscillator, hydrogen atom, and other potentials. Perturbation theory. Offered alternate fall semesters. 3901 Special Topics in Physics 1 to 3 Credits. 3951 Independent Research 1 to 2 Credits 4111 Electricity and Magnetism 1 3 Credits Electrostatics field theory, capacitance, multipole expansion, dielectric properties of matter; magnetic field theory; electromagnetic induction; magnetic properties of matter, Maxwell’s equations and electromagnetic waves. 4121 Electricity and Magnetism 2 3 Credits Advanced electric and magnetic fields; electric and magnetic properties of solids, electromagnetic radiation. 4151 Plasma Physics 3 Credits Single particle motions. Plasmas as fluids. Waves and wave formation in plasmas. Nonlinear effects in plasmas. 4901 Special Topics in Physics 1 to 3 Credits Part of the Physics major program and offered when needed. 4951 Senior Thesis Seminar 1 Credit Written and oral presentation of the complete Capstone Research Project. 4971 Independent Research 1 to 3 Credits 1 to 3 Credits. Part of the Physics major program and offered when needed. Biology 1311, Cells and Molecules GENERAL COURSE GUIDELINES Ohio Northern University, Fall Semester, 2011 Course Overview: Biology 1311 is designed to introduce some of the fundamental concepts and themes that pervade the biological sciences. During the 15-week period, this course will review basic biochemical concepts, cell structure and function, metabolism, and the principles of heredity and gene expression. The intent of this course is to prepare our majors for advanced study in these areas. Your class normally will meet for three, 1-hour lecture sessions each week plus one, 3-hour laboratory period. Required Texts: The following text book is required for Biology 1311 and is available at the ONU Bookstore. 1. Life: The Science of Biology by Sadava et al. 9th edition published by Sinauer (978-1-4292-1962-4). Course Policies: Biology 1311 is a course organized and taught by three different faculty members. Therefore the Department has established several parameters common to all sections being taught this quarter. Course Website: For your convenience, course materials, including homework assignments, Powerpoint lecture notes, and laboratory exercises may be accessed by logging in to: WebCT (http://webctnew.onu.edu), YourBioPortal.com, or the P drive at Biology 1311. Students are welcome to take advantage of material provided by any instructor at these online locations, not just their own. 8/16/2011 Grading: Your final grade will be determined based upon the following criteria: 1. 3 Examinations at 75 Points each 2. Final Examination (50 Points New Material/100 Points Comprehensive) 3. Quizzes & Assignments (lecture + laboratory) 4. 3 Laboratory Practicals 5. Student Oral Presentation Total Points: 225 Points 150 Points 150 Points 150 Points 25 Points 700 Points Grading Scale: A: 90-100%, B: 80-89%, C: 70-79%, D: 60-69%, F: 0-59% Lecture and Final Examinations: All instructors teaching the course participate equally in making up the departmental examinations. These will consist of the Lecture Tests and the Final Exam. The Lecture Exams will consist of a combination of multiple choice, short answer, calculation, and essay questions over the topical areas as indicated in your course syllabus. Prior to each exam, your instructor will provide you with more information regarding test format. The Final Exam will also consist of a variety question formats representing a combination of new and comprehensive material. Since all students take the same examinations, they will be administered at a common time. Lecture tests will be given at 6:50 a.m. on dates indicated in your daily syllabus. The final examination will be administered at 2:00 p.m. on Tuesday, December 13th. Your instructor will assign your location for taking each test. Quizzes & Assignments: During the semester, your instructor may incorporate quizzes (announced or unannounced) and assignments (in class or homework) to increase your understanding and examine your comprehension of the biological principles discussed in class. The quizzes and assignments used by your instructor for this portion of your grade may not be uniform throughout the department. Laboratory Practicals: 3 laboratory exams/practicals will be administered as indicated on the syllabus. These tests will consist of a variety of question formats including multiple choice, problem solving, short answer, etc. Student Presentations: All students will be required to give an oral presentation over a current cell/molecular biology topic. These “current science” presentations will be ~ 5 minutes long and require the use of a visual aid. The topic must be material released within the last 30 days and approved by your instructor. Please see the P drive for a list of approved websites to assist you in your topic search. Two presentations will be scheduled each Friday beginning week 4 and continuing throughout the semester. Extra Credit: There will be no extra credit or bonus points available for this course. Tutoring Help from the Dean’s Office: If you wish to arrange individual tutoring sessions for additional help in this course (in addition to your instructor), please contact the office of the Dean of Arts & Sciences (X2130). Academic Accommodation: “Ohio Northern does not discriminate against qualified individuals with disabilities. Accordingly, the school will provide reasonable academic accommodations when the student provides sufficient documentation describing his or her disability and the accommodation(s) requested in accordance with school procedures.” If you have a documented disability, please inform your instructor during the first week of class so support can be provided to help you be successful in class. If you have any questions about ONU’s policies, please 8/16/2011 - see the student handbook, Appendix E – ONU Disabilities Policy - visit the Disability Services website: http://wwwnew.onu.edu/student_life/disability_services - contact Melissa Verb: 419-772-2534 or m-verb@onu.edu (A &S students). Attendance: An attendance policy is established by each instructor and may not be uniform throughout the department. In general, class attendance is expected for the best possible learning experience, and will almost always improve your grade. Although no points will be awarded for class attendance, your instructor may deduct points for missed classes. Missed assignments cannot be made-up unless the instructor is notified BEFORE the quiz/exercise with a valid excuse (i.e., athletic participation, severe illness). Academic Conduct: The Department takes the issue of academic honesty seriously and we encourage you to conduct yourself with the highest level of integrity at all times. As outlined by the University’s Code of Student Academic Conduct, academic misconduct includes, but is not limited to, plagiarism, cheating, and/or improper collaboration. Instances of academic misconduct will be dealt with in the following manner: a first infraction will result in a student receiving a zero for that assignment. A second infraction will result in a student receiving a failing grade (F) for the course. These are the minimal penalties for academic misconduct in this course and additional actions may be taken if warranted by the nature of the academic misconduct. All actions will be taken as directed by the College of Arts and Sciences Code of Academic Student Conduct. Electronic devices: Laptops may be used during lecture only for taking notes. The use of any other electronic devices is not permitted. This includes cell phones and other text messaging devices, cameras, tablets, and personal music players. Cell phones will be turned off during class time. Violations will result in forfeiture of points. Absolutely no photography is permitted. GENETICS 2101 FALL SEMESTER 2011 OHIO NORTHERN UNIVERSITY INSTRUCTOR INFORMATION Jamie Sanford, Ph.D. Office: 127 Mathile Office Phone: x3016 Cell: 614-571-2276 E-mail: j-sanford@onu.edu OFFICE HOURS M: 11:00-12:00 W: 11:00-12:00 Th: 11:00-1:00 F: 11:00-12:00 LECTURE MEETING TIMES Section 01: 10:00-10:50 a.m. Section 02: 12:00-12:50 p.m. LAB MEETING TIMES Section 01: 8:00-10:45 a.m. Section 02: 12:00-2:45 p.m. Section 03: 3:00-5:45 p.m. Section 04: 6:30-9:15 p.m. TEXTBOOK INFORMATION Text: Brooker, Genetics Analysis and Principles, 4th ed. ISBN: 978-0-07-352528-0 Publisher: McGraw-Hill You may use the 3rd Edition of this textbook, but please note that there may be additional figures included in my Powerpoints that are not in your edition of the text. Also, sometimes I may refer to figures that have a different figure number in your edition of the text. 8/16/2011 READ THIS COURSE SYLLABUS CAREFULLY If you have any questions regarding the syllabus content, you will have the opportunity to address them at the second class meeting. At that time, you will be asked to sign a statement affirming that you have read and understood the information included in the syllabus. Please note that information included in the syllabus (i.e. course requirements, scheduled topics, practical exam dates, etc.) is subject to change to facilitate student learning needs. No changes to the schedule will be made without full explanation to the students. OFFICE HOURS: I reserve the right to alter my office hours, if needed, but in doing so will give you ample notice and provide alternative times that we will be available. You are encouraged to seek assistance during office hours or by scheduled appointment whenever you have questions concerning course topics or your progress in the course. Get help early and as often as you need it. INSTRUCTOR INFORMATION: I am available at all times to help students with issues related to being successful in this course, within reason. At the top of this syllabus you will find my cell phone number, please use this number only if it is absolutely necessary at the time, i.e. an issue that requires immediate attention and cannot wait for an email response. I will always be available via email and will try to reply in the most prompt manner possible at the time. As this is the first year that the instructor is teaching this course, there will be times when there will be some changes to the syllabus, including assignments. I realize that this is an inconvenience to the students and will give students ample notice and explicit explanation when changes are made. I appreciate your flexibility in this course. LABORATORY The lab must be taken concurrently with the lecture portion of the course. As an instructor I strive to integrate as much your lecture material in with your lab material. Therefore, it is possible that at some points in the semester you may find that we do lab related coursework during the scheduled lecture time or vice versa. BIO 2101 COURSE OBJECTIVES AND TOPICS BIO 2101 GENETICS covers classical, molecular and evolutionary genetics. Students will also learn to read and understand primary literature in the discipline and will create, using scientific literature review techniques, a Wiki page dealing with a topic of the student’s choice regarding the genetics of human diseases. Students will also become familiar with the uses of modern techniques to address questions in genetics. Students will also be exposed to the broader societal implications of genetic knowledge and techniques. Therefore, by the end of the course student should… …understand the chromosomal basis of genetics and explain the inheritance of genes (alleles) and the phenotypic consequences of those patterns of inheritance. 8/16/2011 …understand the historical roots of the field of genetics and molecular biology and their relationship to other fields. …understand the application of mathematics and statistics to genetic data. …understand the underlying cause (e.g., linkage, pleiotropy, penetrance) of unexpected patterns of inheritance. …be able to apply genetic techniques (pedigrees, PCR, electrophoresis, DNA sequencing, etc.) in analyzing genetic data and addressing questions in genetics. …understand the molecular mechanisms and enzymes used by the cell to accomplish DNA replication, transcription and translation; describe how splicing contributes to variation in protein expression in different cell types …be able to describe how recently discovered small RNA molecules are redefining/challenging the traditional definition of a gene and the central dogma …be able to describe the means by which prokaryotic and eukaryotic cells regulate gene expression … demonstrate a basic knowledge of the process of cloning a gene into a DNA plasmid a describe how these techniques can be used to answer questions regarding gene function in vitro, in cell cultures or in whole animals …be able to describe some basic modern day genomic capabilities,e.g. advanced sequencing capabilities, bioinformatics, etc. …be able to apply the knowledge gained from coursework to concepts presented in primary literature and vice versa; given a novel research question be able to determine the best molecular/genetic technique(s) that could be utilized to answer the question posed TOPICS TO BE COVERED Review of Cell Structure and Protein Structure & Classical Genetics: Mendel’s Laws Function Mitosis and Meiosis Chromosomal Theory of Inheritance Advanced Mendelian & Non-Mendelian Genetics Genetic Linkage and Mapping History of Modern Genetics Discovery and Molecular Structure of DNA & RNA DNA Replication, Transcription and Translation of mRNA Regulation of Gene Expression in Bacteria Regulation of Gene Expression in Eukaryotes Gene Mutation and DNA Repair Recombination & Transposition Recombinant DNA Technology Biotechnology and Genomics ASSOCIATED READINGS* Relevant text from your Intro Biology Chapter Text 2 Chapter 3 Chapter 3 Chapter 4 & 5 Chapter 6 TBA; PPT Slides Chapter 9 Chapters 11-13 Chapter 14 Chapter 15 Chapter 16 Chapter 17 Chapter 18 Chapters 19-21 * The readings listed above encompass the associated textbook readings. There will often be additional resources and readings associated with each topic. All readings and resources will be announced in class and will always be posted on WEB-CT for the students. ** Population, Quantitative and Evolutionary Genetics will be covered in the LABORATORY portion of this course GRADE DETERMINATION Your final grade in this course will be determined using the scheme shown below. 8/16/2011 LECTURE Category Exams (3) Comprehensive Final Problem Sets (5) Quizzes (6) Homework Literature Summaries (2) Participation* Wiki Page Points 300 135 50 60 50 80 25 100 TOTAL LECTURE POINTS 800 LAB Category Points Lab Notebooks (2 checks) 50 Participation* 30 Skills Practicum 50 Drosophila Written Lab Report 80 Homework/Quizzes 60 S. Oralis PCR Project 75 Mutagenesis Poster Project 125 Bioinformatics Assignment 40 Population Genetics Assignment 40 TOTAL LAB POINTS 550 Your participation grade in lecture and lab is a subjective measure of your classroom and laboratory involvement based on overall attendance, your degree of preparedness, participation in class discussions, cleanliness, cooperative spirit, and willingness to go beyond the call of duty. For your lab partners will also provide peer feedback valuable in determining this grade. Specific details on each assignment will be given to students as they occur throughout the semester. Descriptions of all assignments and/or projects, along with any corresponding rubric when appropriate. The guidelines and instructions for this assignment will be given to the students in early October. The Skills Practicum in lab will be announced prior two weeks prior the date of the practicum. The practicum may include: basic calculations of concentrations, Pipetting accuracy, sterile technique, agarose gel loading and microscopy skills. A basic description of the lab projects we will be doing this semester will be covered in Week 2 of the course. Labs will be posted as PDF files on WEB-CT as they are done. GRADE SCALE Guaranteed letter grades for both lecture and lab will be based on the following scale: A B C D F 90-100% 80-89% 70-79% 60-69% 59-0% PRE- AND POST- COURSE ASSESSMENT In this course you will be exposed to reading and critically analyzing primary literature as it relates to the field of Genetics. As such, you will be given an UNGRADED Pre- and Post- Course Assessment Questions based on a primary literature article. Details will be given during the second week of the course. 8/16/2011 LECTURE CONDUCT: ATTENDANCE POLICY, PARTICIPATION, CELL PHONES You are expected to attend each lecture session and be prompt in doing so. The chapter(s) and/or pages to be discussed each day should be read prior to the lecture period. You are expected to be an active participant in the classroom and laboratory, asking questions and engaging in discussions. The use of cellular phones during the lecture or laboratory sessions is prohibited. This includes not only phone calls but also sending/receiving text messages. If you violate this policy, you will be asked to leave the class and will be counted as absent, regardless of the amount of time remaining in the period. ISSUE RESOLUTION If a problem arises regarding class or lab that requires resolution between professor and student, please schedule an appointment to discuss the issue personally. Email is not considered an appropriate avenue for discussion or mediation. ADA COMPLIANCE Academic Accommodation: “Ohio Northern does not discriminate against qualified individuals with disabilities. Accordingly, the school will provide reasonable academic accommodations when the student provides sufficient documentation describing his or her disability and the accommodation(s) requested in accordance with school procedures.” If you have a documented disability, please inform your instructor during the first week of class so support can be provided to help you be successful in class. If you have any questions about ONU’s policies, please * See the student handbook, Appendix E – ONU Disabilities Policy * Visit the Disability Services website: http://wwwnew.onu.edu/student_life/disability_services * Contact Melissa Verb: 419-772-2534 or m-verb@onu.edu (A &S students). E-MAIL CORRESPONDENCE / WEB-CT / TECHNOLOGY I will rely on e-mail correspondence and WEB-CT to deliver assignments and announcements throughout the semester. You are expected to check your email on a regular basis. You must use your ONU email account because that is where I will send all e-mails. Additionally, all students are required to set up a WEB-CT account to access the BIO2101 course. Make sure you can properly use WEB-CT as a tool and platform for your learning process this semester. If you are having problems with your email or WEB-CT access you should inform me ASAP and check to be sure that you are aware of all assignments and announcements. If you fail to turn in an assignment as a result of not checking your e-mail or WEB-CT, you forfeit the opportunity to make up the assignment. Laptops – If you have a laptop, it would be considered a good practice to bring that laptop to class and lab. ASSIGNMENTS: HOMEWORK, LITERATURE ASSIGNMENTS, QUIZZES,ETC. Periodically you will receive homework assignments. The due date for the homework assignment will be specified when it is given. Reading and critical evaluation of primary literature will also be relied upon extensively in this course to help solidify and expand upon concepts covered in lecture. You will be given corresponding writing assignments or questions in conjunction with these readings; dates of these assignment due dates will be announced in lecture. LATE ASSIGNMENT POLICY 8/16/2011 All assignments given in class will assigned a specific due date and time, generally speaking assignments will be due at the start of class. Assignments not turned in on time will result in a drop of a letter grade for every day that it is late. If you do not hand in a particular assignment at the designated time, i.e. you hand in assignment at 5 p.m. that was due at the start of class, this counts as 1 day late. EXAMS Exam material will be from the lecture notes, primary papers, and discussions. Exams will be a combination of multiple choice, diagram identification, fill in the blank, matching, short answer and essay questions. Absence from an exam without prior approval from the instructor will result in a zero grade for that exam. There will be no make-up exams after the fact! On receiving your graded exam, you should look over the exam/paper to determine if any inconsistencies exist. Any discrepancies must be rectified within five class days of receiving the graded exam. After that time there will be no further consideration of grade changes for that exam. If a student must miss an examination for a legitimate and compelling reason (student is ill; illness or death in the family) the student must notify us via email PRIOR to the examination. As soon as possible thereafter, the student must submit in writing the reason for the absence, along with a physician’s note, etc. Students will ONLY be granted permission to take a make-up examination provided ALL of the above guidelines have been met. ACADEMIC HONESTY Academic integrity is one of the basic principles of a university community. Ohio Northern University encourages and expects the highest standards of academic honesty from all students. The Arts and Sciences Code of Academic Student Conduct states that cheating, plagiarism, and other forms of academic dishonesty are subject to disciplinary action. Refer to the Arts and Sciences Code of Academic Student Conduct for additional information. For information on plagiarism, I recommend that you visit www.plagiarism.com for definitions, examples and ways to avoid plagiarism. In this course we will also be utilizing the web resource TURNITIN.COM to avoid and detect any plagiarism that may occur on written assignments. Proper citation methods are key to helping avoid accidental plagiarism. Please note that in a laboratory course, academic honesty extends to experimentation and results, e.g. you cannot use the results of another student’s experiments as your own, you may not alter data you obtain in any way, etc. GENERAL LAB POLICIES: Attendance – Presence in lab is mandatory. However, if an absence should be necessary (see above guidelines), the instructor must be informed of the absence prior to lab. Note that it is in your best interest to attend lab as any exercises or assignments completed during lab may not necessarily be able to be made up due to the experiential nature of the course. Respect of Equipment - Throughout this semester you will be using a lot of expensive equipment. You are to treat all equipment with extreme respect and with the knowledge that other/future students will be using this equipment as well, so the equipment must always be left in the same condition in which 8/16/2011 you found it. This is especially true when using pipettes. The instructor will post resources on WEB-CT regarding proper use of equipment as equipment is used throughout the course. It is assumed that you will read and/or watch these resources. Equipment Damage – If damage should occur to equipment or supplies, the cost of the item(s) will be charged to the student in order to assist with replacement costs (to a $100.00 maximum). Failure to pay for damage incurred will result in a hold on course grades until said fee is paid. At the beginning of the lab period report any equipment damage, not incurred by you, so that you will not be held responsible for that damage. If it becomes obvious that you are unable to care for your equipment, the instructor reserves the right to restrict your use. Lab Safety – Every student is required to carefully read STANDARD OPERATING PROCEDURES sheet that will be posted on WEB-CT; each student must then sign the Student Sign-Off Sheet to establish your commitment to maintain these procedures. Lab Protection – Lab goggles will be assigned for your use when handling hazardous materials. ALWAYS wear a lab coat when working in the lab to protect clothing and skin from contamination or stains. Gloves are also required when in contact with potentially hazardous materials. Close toe shoes are required to avoid accidental spillage of biohazards on your feet. Lab Etiquette –It is the instructor’s job to facilitate lab (not clean up after grown adults), please maintain your own lab space properly as it will determine, in part, your lab participation grade. Proper space management is essential in avoiding accidental infection or contamination. You must always leave the lab in the condition in which you entered it. Also, please see tube labeling below as part of proper lab etiquette. Solutions – In this lab you will be doing independent research projects, which means there may be many times when I may not be immediately aware that a particular solution is running low. Please make sure that you inform me when a solution needs made. Also, if you make a particular stock solution, make sure to aliquot out a bit for yourself and leave the rest in the designated stock solution area. Please also be keenly aware of the storage conditions for any solutions/reagents that you are using for experimentation. Responsibility – In this course you will all be allowed significant independence, which in turn entails being responsible at all times in the lab, i.e. adhering to the SOP and the guidelines of this syllabus. If I notice that these guidelines are continually not being met, it will likely result in removal of lab privileges for all students. Time Outside of Lab: Lab projects require that more attention be paid to time management than you may be accustomed to. For example, one lab with Drosophila may require 1.5 hrs to set up crosses, but then will also require several visits during the week to successfully maintain your live cultures. Students are expected to do the work necessary to complete all lab projects, often at their own convenience. When lab projects begin, the instructor will inform the students of times when they will be able to access the lab outside of their scheduled lab time. LABELING OF TUBES, ETC: Proper labeling of experiments, particularly tube labeling, is critical to ALL molecular biology experiments, failure to properly label tubes can result in tragic things such as having your tube accidentally miscarded or having to repeat an experiment due to ambiguity of the contents contained within the tube. All tubes, racks, etc. in use by a particular student MUST be labeled with the following information. - Initials (Use full name when space permits) - Experiment Identification, e.g. plasmid pXYZ mini prep - Date 8/16/2011 BIO 452, SP11 Label tubes/Racks/Boxes in multiple locations, e.g. for an eppendorf tube, label the top AND the side. LABORATORY NOTEBOOK A proper laboratory notebook is a DAILY record of your activities, data, interpretations, and epiphanies while conducting your research. Your notebook must include, but is not limited to the following: 1) Every Page must be numbered and dated. 2) Lab notebook must be maintained in INK, not pencil. 3) Purpose of the experiment/procedure you are performing and some indication of the results you expect 4) Daily Record of Results 5) Discussion of those results Your lab notebook should be a reflection of everything that you are doing in lab, AS YOU ARE DOING IT. You should not ever be going back and filling in the blanks of your lab notebook the day(s) after you have conducted the experiment. You should be writing/recording in your notebook before, during and after every experiment. Your lab notebook MUST include sufficient detail such that any outside person who reads your notebook would be able to exactly repeat your experiments. When doing a repeat of a particular experiment, you can refer back to the initial page on which you described the experiment, but be sure to note any modifications. If you are performing a protocol from another source, either properly cite the source or staple a copy of the protocol in your notebook. You may use either a bound laboratory notebook or a 3-ring binder as your laboratory notebook, so long as the above guidelines are met. Your laboratory notebook will be subjected to 2 UNANNOUNCED checks during the course of the semester, with each check being worth 25 pts. *THIS SYLLABUS IS SUBJECT TO CHANGE TO FACILITATE THE LEARNING NEEDS OF THE CLASS IMPORTANT SEMESTER DATES FOR BIO 2101 : Exam #1 Wednesday, September 28th Fall Recess Friday, October 7th -Tuesday October 11th (No Class October 7th, Reading Day) Exam #2 Monday, October 31st Thanksgiving Break Wednesday, November 23rd-Sunday November 27th Exam #3 Monday, December 5th Final Exam (MWF 10am) Friday, December 16th 8:00 a.m. to 10:30 a.m. Final Exam (MWF 12pm) Wednesday, December 14th 10:45 a.m.- 1:15 p.m. 8/16/2011 Instructor: Dr. MirceaAnghelescu Office Hours: M 10-12/3-4 , Fri 10-12 or by appointment Lectures will be from 1:00-1:50PM in SA105 (Monday,Friday). The laboratory meets in the Mathile Center room 139 check your schedule for the time. Phone: 419-772-4216 Office: Meyer 158 Email: m-anghhelescu@onu.edu Course Website:https://webct-new.onu.edu Required and recommended textbooks and supplies Required: Course Bundle ISBN: 9780558176815 Marieb, E.N., and K. Hoehn. 2010. Human Anatomy & Physiology, Eighth Edition. Pearson Benjamin Cummings, San Francisco, CA. (If purchasing the textbook separately the ISBN 13 is: 9780805395693). Older editions (6 th, 7th) of the current textbook are acceptable substitutes. Pearson Integrate Biology 231 Anatomy & Physiology 1: 2009-10 Laboratory Manual and Workbook. Pearson Benjamin Cummings, San Francisco, CA.No substitutes are acceptable for the lab manual. Lab Coats and gloves – we will provide powder-free nitrile gloves and disposable lab coats as part of your lab fee. If you prefer, you may purchase professional washable lab coats and disposable gloves on your own. Medical scrubs also are acceptable. If you choose to purchase your own gloves, I recommend that you purchase a box of gloves of the appropriate size rather than gloves sold as individual pairs, which tend to be much more expensive. Recommended: For those whose careers will emphasize an extensive clinical knowledge of human anatomy, I recommend purchasing a copy of Netter, F.H. 2006. Atlas of Human Anatomy, 4th Edition. W.B. Saunders, Philadelphia, PA, (ISBN13:9781416036999) or any other recent editions. Course objectives and content This course is an introduction to the structure of the human body and the functional relationships among its parts, focusing on the integumentary, skeletal, muscular, and nervous systems and an introduction to the anatomy and histology of the respiratory, digestive and reproductive systems. Learning objectives: 1. Be able to use proper terminology to describe anatomical orientation and the planes of section through the human body and its organs and cavities. 2. Be able to recognize and describe the primary tissue types and the specialized tissues of the integumentary, skeletal, muscular, and nervous systems. 3. Understand and be able to describe the organization and structure of the organs of the integumentary, skeletal, muscular and nervous systems. 4. Understand basic biomechanics of the skeletal and muscular systems. 8/16/2011 5. Understand and be able to explain the physiology of the integumentary, skeletal, muscular, and nervous systems and the concepts of homeostasis and feedback as they pertain to those systems. 6. Be able to recognize and identify human skeletal, muscular, and nervous organs in human cadavers and models. 7. Be able to recognize different structures and organs from the respiratory, digestive and reproductive systems. Course requirements You are expected to know a reasonable amount of fundamental biology upon entering this course, including at least a superficial understanding of the levels of biological organization, biological chemistry, cell structure, function, and energetics, and the basic anatomy of the human body and its organ systems. You can review these topics in the first four chapters of your textbook. Attendance: You are expected to attend the lectures and are solely responsible for any material missed for any reason. You are required to attend and participate in the laboratory. For excused absences from the laboratory, you may be permitted to attend another lab section or study the lab materials off hours. Final Exam: Friday December 16th 2011 SA 105, time 10:45AM-1:15 PM Performance evaluation Your final grade will be determined by your performance on assignments as follows: Assignment Midterm exam Comprehensive final exam Laboratory practical exams Lab assignments Quizzes Approximate weight 25% 25% 30% 10% 10% I will use the following scale, rounded to the nearest whole percent to calculate your final grade: A 90-100% B 80-89% C 70-79% D 60-69% F ≤ 59% Your positive, constructive participation in class, particularly in lab will go a long way toward my decision concerning borderline cases. The midterm exam will be given in the regular classroom at the regular meeting time. The format of both the midterm and final exams may include short answer, fill-in-the-blank, definitions, and matching questions. You may need to label diagrams or identify labeled items on diagrams. Topics discussed in lab are fair game for the lecture exams. The laboratory practical exams will be given in the lab room on the assigned day. You will not be permitted to use any items on the lab exams other than a writing implement. These are timed exams with limited time per question. As the semester progresses, you are expected to read the chapters in the lab manual relevant to each lab before attending that lab. Throughout and at the end of each chapter there are review questions for you to answer. You will turn in your lab manual for grading at the time of each lab exam. You will receive credit for completing those review questions for each chapter, up to 10% of your total grade for completing all the questions in the lab manual. Quizzes will be administered through WebCT or in class (I will reserve the right to quiz you in the beginning of each lecture or lab, in which case the quiz will consist of 10 to 15 questions related to the material covered in the previous classes). These will consist of multiple choice, matching, and fill-in-the-blank questions over topics relevant to either lecture or lab or both. Test policy 8/16/2011 If you miss an assigned test or practical exam, a make-up will be granted only in the event of a conflict with an official universitysponsored event (advanced notice required) or approved extenuating circumstances. I recognize that some events requiring your absence are not predictable. In such instances, you need to make a good faith effort to contact me as soon as possible regarding your absence. Policy on disabilities We will make reasonable accommodations for any students with disabilities. If you believe that you have a disability and need accommodation, go to the following website: http://www-new.onu.edu/student_life/disability_resources and contact the appropriate college representative for more information. Once your request for accommodation is approved, the college will contact your instructor concerning the necessary accommodation. You will still need to notify your instructor in advance of any assignment concerning which options among those approved by the college you would like to use. Conduct and attire In both lecture and laboratory, silence cell phones and other personal electronic devices. Do not use your phones for texting or other activities during class. At the first instance of personal electronics usage for purposes other than note-taking in class, the class will be reminded of this policy. For any subsequent infraction, the offending individual will have 5% deducted from his or her grade, which may be made up by completing an extra assignment of the instructor’s design (remediation). You may record lectures if you choose and you may use a laptop, netbook, or tablet during lecture for taking notes. Do not, however, use such devices for purposes of recreation (e.g., games, social networking, and so on) during class. The above remediation policy applies here as well. Food, beverages and other consumables are prohibited in the laboratory. Proper laboratory attire, including closed-toed shoes is required as the preservatives used on the cadavers are caustic. The materials and specimens we will use in the laboratory are expensive and difficult to replace. Therefore, I expect you to show proper care and responsibility for all the materials and specimens and to follow instructions when using or studying them. The human cadavers that we use are the remains of real people who were generous enough to donate their bodies for others to use in the hope that all of us may benefit from the experience. Please recognize and respect their generosity by treating their remains with dignity and by learning as much as you can from them. Policy on academic misconduct As indicated in the Student Code of Conduct academic misconduct includes but is not limited to plagiarism, cheating, and improper collaboration. The penalty for the first infraction is a zero on that assignment. The penalty for a subsequent infraction is a failing grade in the course. Other disciplinary actions will be taken as directed by the College of Arts and Sciences Code of Academic Student Conduct. Disclaimer This syllabus and attached schedule represents the intent of the instructor in offering this course. While every attempt will be made to follow this syllabus, the instructor reserves the right to modify the contents as necessary to meet the needs of the course and to accommodate scheduling changes due to unforeseen events. 8/16/2011 Tentative Lecture Schedule Week 1 Topic Introduction, homeostasis and negative feedback Cell biology overview (Review on your own) Relevant reading in M&H pp. 1-4, 8-11 pp. 61-68, 79-81 Online quiz 2 3 Membrane transport and resting membrane potential Overview of tissues (Review on your own) The integumentary system Online quiz pp. 68-77, 77-79 pp.113-139 pp. 148-165 Skeletal cartilage, bone tissue, bone structure Bone growth and remodeling pp. 131-133, 173, 177-181 pp. 182-188 Online quiz 4 5 6 Repair of fractures, other homeostatic imbalances Skeletal muscle overview and structure Online quiz Sliding filament theory of muscle contraction Motor units, twitch, changes in stimuli, types of contraction Muscle metabolism Force of contraction pp. 188-194 pp. 275-284 pp. 284-289 pp. 289-296 pp. 296-300 pp. 300-304 Online quiz 7 Nervous system overview, nervous tissue Membrane potentials and propagation pp. 134-136, 385-395 pp. 395-406 Midterm exam 8 Synapses, neurotransmitters and their receptors Neural integration, anatomy of the brain pp. 406-421 pp. 429-451 Online quiz 9 10 Meninges, CSF and blood supply Homeostatic imbalances of the brain Online quiz Spinal cord anatomy Spinal cord pathways and homeostatic imbalances pp. 460-464 pp. 464-466 pp. 470-477 8/16/2011 Online quiz 11 12 13 14 15 PNS: structure of peripheral nerves PNS: sensory receptors, integration, somatosensory system Online quiz Somatic motor system and reflexes The special senses: vision (a) Online quiz The special senses : vision (b) The special senses: hearing and equilibrium Online quiz pp. 491-493 pp. 484-491 pp. 512-519 pp. 551-569 pp. 474-587 The special senses: olfaction and taste The autonomic nervous system Online quiz pp. 569-573 pp. 525-541 The autonomic nervous system (cont) Review pp. 525-541 Comprehensive Final Exam * M&H = Marieb&Hoehn (2010). 8/16/2011 Week 1 Tentative Laboratory Schedule Topic Anatomical terminology Tissues overview (histology) 2 Skeletal system overview, axial skeleton 3 Appendicular skeleton 4 Articulations and movement 5 First laboratory exam Manual pp. 1-86 Completed 6 Muscular system overview Trunk musculature 7 Muscles of the pectoral girdle and upper limb 8 Muscles of the pelvic girdle and lower limb 9 Second laboratory exam Manual pp. 87-138 Completed 10 Spinal cord and spinal nerves, brain and cranial nerves (anatomy/histology) 11 Reflex function lab 12 13 14 15 Anatomy and histology of the respiratory system Anatomy and histology of the digestive system Anatomy and histology of the reproductive system Final lab exam * M&H = Marieb&Hoehn (2010). Instructor: Dr. MirceaAnghelescu Office Hours: M 10-12/3-4 , Fri 10-12 or by appointment Lectures will be from 1:00-1:50PM in SA105 (Monday,Friday). The laboratory meets in the Mathile Center room 139 check your schedule for the time. Phone: 419-772-4216 Office: Meyer 158 Email: m-anghhelescu@onu.edu Course Website:https://webct-new.onu.edu 8/16/2011 Required and recommended textbooks and supplies Required: Course Bundle ISBN: 9780558176815 Marieb, E.N., and K. Hoehn. 2010. Human Anatomy & Physiology, Eighth Edition. Pearson Benjamin Cummings, San Francisco, CA. (If purchasing the textbook separately the ISBN 13 is: 9780805395693). Older editions (6 th, 7th) of the current textbook are acceptable substitutes. Pearson Integrate Biology 231 Anatomy & Physiology 1: 2009-10 Laboratory Manual and Workbook. Pearson Benjamin Cummings, San Francisco, CA.No substitutes are acceptable for the lab manual. Lab Coats and gloves – we will provide powder-free nitrile gloves and disposable lab coats as part of your lab fee. If you prefer, you may purchase professional washable lab coats and disposable gloves on your own. Medical scrubs also are acceptable. If you choose to purchase your own gloves, I recommend that you purchase a box of gloves of the appropriate size rather than gloves sold as individual pairs, which tend to be much more expensive. Recommended: For those whose careers will emphasize an extensive clinical knowledge of human anatomy, I recommend purchasing a copy of Netter, F.H. 2006. Atlas of Human Anatomy, 4th Edition. W.B. Saunders, Philadelphia, PA, (ISBN13:9781416036999) or any other recent editions. Course objectives and content This course is an introduction to the structure of the human body and the functional relationships among its parts, focusing on the integumentary, skeletal, muscular, and nervous systems and an introduction to the anatomy and histology of the respiratory, digestive and reproductive systems. Learning objectives: 8. Be able to use proper terminology to describe anatomical orientation and the planes of section through the human body and its organs and cavities. 9. Be able to recognize and describe the primary tissue types and the specialized tissues of the integumentary, skeletal, muscular, and nervous systems. 10. Understand and be able to describe the organization and structure of the organs of the integumentary, skeletal, muscular and nervous systems. 11. Understand basic biomechanics of the skeletal and muscular systems. 12. Understand and be able to explain the physiology of the integumentary, skeletal, muscular, and nervous systems and the concepts of homeostasis and feedback as they pertain to those systems. 13. Be able to recognize and identify human skeletal, muscular, and nervous organs in human cadavers and models. 14. Be able to recognize different structures and organs from the respiratory, digestive and reproductive systems. Course requirements You are expected to know a reasonable amount of fundamental biology upon entering this course, including at least a superficial understanding of the levels of biological organization, biological chemistry, cell structure, function, and energetics, and the basic anatomy of the human body and its organ systems. You can review these topics in the first four chapters of your textbook. Attendance: You are expected to attend the lectures and are solely responsible for any material missed for any reason. You are required to attend and participate in the laboratory. For excused absences from the laboratory, you may be permitted to attend another lab section or study the lab materials off hours. Final Exam: Friday December 16th 2011 SA 105, time 10:45AM-1:15 PM 8/16/2011 Performance evaluation Your final grade will be determined by your performance on assignments as follows: Assignment Midterm exam Comprehensive final exam Laboratory practical exams Lab assignments Quizzes Approximate weight 25% 25% 30% 10% 10% I will use the following scale, rounded to the nearest whole percent to calculate your final grade: A 90-100% B 80-89% C 70-79% D 60-69% F ≤ 59% Your positive, constructive participation in class, particularly in lab will go a long way toward my decision concerning borderline cases. The midterm exam will be given in the regular classroom at the regular meeting time. The format of both the midterm and final exams may include short answer, fill-in-the-blank, definitions, and matching questions. You may need to label diagrams or identify labeled items on diagrams. Topics discussed in lab are fair game for the lecture exams. The laboratory practical exams will be given in the lab room on the assigned day. You will not be permitted to use any items on the lab exams other than a writing implement. These are timed exams with limited time per question. As the semester progresses, you are expected to read the chapters in the lab manual relevant to each lab before attending that lab. Throughout and at the end of each chapter there are review questions for you to answer. You will turn in your lab manual for grading at the time of each lab exam. You will receive credit for completing those review questions for each chapter, up to 10% of your total grade for completing all the questions in the lab manual. Quizzes will be administered through WebCT or in class (I will reserve the right to quiz you in the beginning of each lecture or lab, in which case the quiz will consist of 10 to 15 questions related to the material covered in the previous classes). These will consist of multiple choice, matching, and fill-in-the-blank questions over topics relevant to either lecture or lab or both. Test policy If you miss an assigned test or practical exam, a make-up will be granted only in the event of a conflict with an official universitysponsored event (advanced notice required) or approved extenuating circumstances. I recognize that some events requiring your absence are not predictable. In such instances, you need to make a good faith effort to contact me as soon as possible regarding your absence. Policy on disabilities We will make reasonable accommodations for any students with disabilities. If you believe that you have a disability and need accommodation, go to the following website: http://www-new.onu.edu/student_life/disability_resources and contact the appropriate college representative for more information. Once your request for accommodation is approved, the college will contact your instructor concerning the necessary accommodation. You will still need to notify your instructor in advance of any assignment concerning which options among those approved by the college you would like to use. 8/16/2011 Conduct and attire In both lecture and laboratory, silence cell phones and other personal electronic devices. Do not use your phones for texting or other activities during class. At the first instance of personal electronics usage for purposes other than note-taking in class, the class will be reminded of this policy. For any subsequent infraction, the offending individual will have 5% deducted from his or her grade, which may be made up by completing an extra assignment of the instructor’s design (remediation). You may record lectures if you choose and you may use a laptop, netbook, or tablet during lecture for taking notes. Do not, however, use such devices for purposes of recreation (e.g., games, social networking, and so on) during class. The above remediation policy applies here as well. Food, beverages and other consumables are prohibited in the laboratory. Proper laboratory attire, including closed-toed shoes is required as the preservatives used on the cadavers are caustic. The materials and specimens we will use in the laboratory are expensive and difficult to replace. Therefore, I expect you to show proper care and responsibility for all the materials and specimens and to follow instructions when using or studying them. The human cadavers that we use are the remains of real people who were generous enough to donate their bodies for others to use in the hope that all of us may benefit from the experience. Please recognize and respect their generosity by treating their remains with dignity and by learning as much as you can from them. Policy on academic misconduct As indicated in the Student Code of Conduct academic misconduct includes but is not limited to plagiarism, cheating, and improper collaboration. The penalty for the first infraction is a zero on that assignment. The penalty for a subsequent infraction is a failing grade in the course. Other disciplinary actions will be taken as directed by the College of Arts and Sciences Code of Academic Student Conduct. Disclaimer This syllabus and attached schedule represents the intent of the instructor in offering this course. While every attempt will be made to follow this syllabus, the instructor reserves the right to modify the contents as necessary to meet the needs of the course and to accommodate scheduling changes due to unforeseen events. 8/16/2011 Tentative Lecture Schedule Week 1 Topic Introduction, homeostasis and negative feedback Cell biology overview (Review on your own) Relevant reading in M&H pp. 1-4, 8-11 pp. 61-68, 79-81 Online quiz 2 3 Membrane transport and resting membrane potential Overview of tissues (Review on your own) The integumentary system Online quiz pp. 68-77, 77-79 pp.113-139 pp. 148-165 Skeletal cartilage, bone tissue, bone structure Bone growth and remodeling pp. 131-133, 173, 177-181 pp. 182-188 Online quiz 4 5 6 Repair of fractures, other homeostatic imbalances Skeletal muscle overview and structure Online quiz Sliding filament theory of muscle contraction Motor units, twitch, changes in stimuli, types of contraction Muscle metabolism Force of contraction pp. 188-194 pp. 275-284 pp. 284-289 pp. 289-296 pp. 296-300 pp. 300-304 Online quiz 7 Nervous system overview, nervous tissue Membrane potentials and propagation pp. 134-136, 385-395 pp. 395-406 Midterm exam 8 Synapses, neurotransmitters and their receptors Neural integration, anatomy of the brain pp. 406-421 pp. 429-451 Online quiz 9 10 Meninges, CSF and blood supply Homeostatic imbalances of the brain Online quiz Spinal cord anatomy Spinal cord pathways and homeostatic imbalances pp. 460-464 pp. 464-466 pp. 470-477 8/16/2011 Online quiz 11 12 13 14 15 PNS: structure of peripheral nerves PNS: sensory receptors, integration, somatosensory system Online quiz Somatic motor system and reflexes The special senses: vision (a) Online quiz The special senses : vision (b) The special senses: hearing and equilibrium Online quiz pp. 491-493 pp. 484-491 pp. 512-519 pp. 551-569 pp. 474-587 The special senses: olfaction and taste The autonomic nervous system Online quiz pp. 569-573 pp. 525-541 The autonomic nervous system (cont) Review pp. 525-541 Comprehensive Final Exam * M&H = Marieb&Hoehn (2010). 8/16/2011 Week 1 Tentative Laboratory Schedule Topic Anatomical terminology Tissues overview (histology) 2 Skeletal system overview, axial skeleton 3 Appendicular skeleton 4 Articulations and movement 5 First laboratory exam Manual pp. 1-86 Completed 6 Muscular system overview Trunk musculature 7 Muscles of the pectoral girdle and upper limb 8 Muscles of the pelvic girdle and lower limb 9 Second laboratory exam Manual pp. 87-138 Completed 10 Spinal cord and spinal nerves, brain and cranial nerves (anatomy/histology) 11 Reflex function lab 12 13 14 15 Anatomy and histology of the respiratory system Anatomy and histology of the digestive system Anatomy and histology of the reproductive system Final lab exam * M&H = Marieb&Hoehn (2010). Biology 2511, Principles of Ecology, Section 01 (CRN: 21359) Ohio Northern University, Fall Semester, 2011 Instructor: Jay Mager Campus Address: 155 Meyer Hall; Phone: 419-772-2333, e-mail: j-mager@onu.edu Office Hours: Monday 2-3 p.m., Wednesday 1-3 p.m., Friday, 1– 3 p.m. (or by appointment) Each week, lectures meet: Mondays, Wednesdays, & Fridays, 3:00 - 3:50 p.m., in room: 138 Mathile Center 8/16/2011 Each week, laboratories meet: Tuesdays, 12:00 - 2:45 p.m., in room: 138 Mathile Center Required Texts: Krebs, Charles J. 2008. Ecology: the experimental analysis of distribution and abundance, 6th ed. New York: Benjamin Cummings, Inc. (ISBN-13: 978-0321507433) McMillan, Victoria E. 2006. Writing Papers in the Biological Sciences, 4th edition. Boston: Bedford/St. Martin’s. (ISBN: 0-312-44083-9) Course Objectives: This course will introduce you to some of the fundamental concepts of ecology. Ecology is an integrative science incorporating many disciplines (e.g., botany, zoology, evolution, geology, algebra, calculus, microbiology, animal behavior, statistics) that facilitate a more comprehensive understanding the relationships between organisms and their environment. It also is a science that has broad application to many circumstances that are not related directly to the biological sciences (e.g., philosophy, sociology, and economics); therefore, it is a discipline that is often used (and misused) by many individuals of various professional interests. Therefore, while this ten-week course will provide academic ‘tools’ that you can use for future coursework and perhaps professional careers, it also will have application to a number of biological, economic, and sociological issues that you may previously not have even contemplated. Most importantly, I hope it is also a course that you will truly enjoy! Course Requirements & Policies: Grading. Your final grade will be determined from your ability to meet the following criteria: 1. 2. 3. 4. 5. 6. 7. Preliminary Examination I Preliminary Examination II Preliminary Examination III Final Examination (Wed., Dec. 14, 2-4:30 p.m.) Assignments, Worksheets, Problem Sets Research Paper Environmental Threat Presentation Final Grade: 15% 15% 15% 15% 15% 15% 10% 100% Grading Scale: A: 90-100%, B: 80-90%, C: 70-80%, D: 60-70%, F: 0-60% 1. Preliminary and Final Examinations: Sixty percent of your final grade will be determined from your performance on three preliminary examinations (September 19 and October 19) and one final examination (to be determined). Each exam will test you primarily on the material that followed the previous examination, but may also incorporate themes covered by previous examinations. In other words, do not be quick to forget the material you learned early in the semester! 2. Assignments, Worksheets, and Problem Sets. To better understand some of the analytical tools and methods ecologists use to describe and compare populations, communities, and ecosystems, it is sometimes helpful to actually conduct such analyses with actual data sets. Either from data that you will gather in class or that I will provide, you will complete a number of homework assignments during the semester. All assignments should be handed in at the beginning of class on the day they are due (please note tentative due dates in the syllabus). Unless arrangements are 8/16/2011 made in advance, I will deduct 10% per day for all late work. To ensure that your assignments get to me in time, you MUST hand every assignment directly to me (no emails). It is your responsibility to ensure that I have received all tardy assignments. 3. Research Paper. To better understand the scientific process and the art of scientific writing you will design and complete a small research project. Working in groups of 1-4 students, you will design and conduct an approved research project. The topic is of your choice. Keep in mind that with time constraints your project should be relatively simple and straightforward, but also should be designed to adequately address a scientific question. As a group, you must submit a oneparagraph proposal that describes the ecological problem/question, the hypothesis and prediction(s) to be tested, and the methodology/logic used to address these predictions. Upon approval, you will conduct your research, then, following the protocol and guidelines for formatting a paper to be submitted to an ecological journal, you will each individually write and submit a 5-page scientific paper. 4. Environmental Threat Symposium & Presentation. Many of you are interested in this course because of its relevance and application to environmental issues. Because we cover a lot of other information during the semester, we unfortunately will be unable to cover those environmental issues that may be of great interest to you. One way we could address these interests would be for you to research a topic of your choice (with my approval) and teach the class about this environmental issue. For the final laboratory periods of the semester we will have an ‘environmental issue symposium’ where you will present a 10-minute talk to educate the class about your issue. Because we all have broad and diverse interests, there is great flexibility in the topics you can choose; however, I do require that you research your topic well by considering peer-reviewed primary literature. Also note that you will be held responsible for the material presented during the symposium, and that material from the symposium may be used for the final exam. I will provide further guidelines regarding the format and deadlines for the lectures within the next few weeks. Your Responsibilities: 1. Attend lectures. I will not require that you attend lectures. That is a matter for you to decide. However, through attending lectures you will be better able to comprehend the vast amount of material we will cover in ten weeks. Out of respect for the rest of the class, please come to class on time and prepared to participate in class discussions, having read the assignments beforehand. Most, if not all, of the material we discuss will be introduced to you during the lecture section. Lectures are designed to provide an organized synopsis and perhaps some insight regarding the logic responsible for formulating many of the concepts, and will serve as the foundation to the discussions and writing. Although coming to lectures is optional, I do require that you must attend class during both laboratory and examination dates. If you are unable to attend class on these dates, I require that you MUST bring written documentation of your illness, university activity, or other circumstance that prevents you from attending. 2. Academic Misconduct Policy. Although I encourage you to work with others, all work you submit for grading should be written by you alone! Please refer to the University’s Code of Student Academic Conduct (i.e., Appendix D in Ohio Northern University’s Student Handbook, which you received upon matriculation) for a description of the potential disciplinary actions associated with academic misconduct. 3. Read the assignments. In addition to the assigned readings, I expect you to read the additional assigned papers listed within the syllabus before class. Your ability to thoughtfully and critically discuss many of the topics often reflects the time and effort in understanding the assigned readings. Please do come to class prepared, having read the articles beforehand. 4. Actively participate in discussions and activities. The success of this course rests on your ability to digest and comprehend the topics presented during lectures and laboratories. Your ability to comprehend these topics is related not only to your having read the material beforehand, but also how well you can communicate your thoughts and ideas with others. Therefore, your success in this course really depends on your willingness and ability to discuss the issues at hand. Discussions are most productive when all ideas and thoughts are considered and respected. Remember, there is never an “incorrect” nor “stupid” answer or idea to bring forth during discussion. Also keep in mind that some people take longer than others to verbalize their thoughts- be patient and respectful of others. Additionally, if at times you find yourself doing most of the talking and dominating a discussion, it may be best to listen to what others have to say. 8/16/2011 Biology 2511 Tentative Syllabus, Fall Semester 2011 Date Week 1 Mon., Aug. 22 Tues., Aug. 23 Wed., Aug. 24 Fri., Aug. 26 Week 2 Mon., Aug. 29 Tues., Aug. 30 Wed., Aug. 31 Fri., Sept. 2 Week 3 Mon. Sept. 5 Tues., Sept. 6 Wed., Sept. 7 Fri., Sept. 9 Week 4 Mon., Sept. 12 Tues., Sept. 13 Wed., Sept. 14 Fri., Sept. 16 Topic Hardy-Weinberg Worksheet LABORATORY 2: Distance Sampling Assmt PRELIMINARY EXAMINATION I LABORATORY 4: Molles, pp. 201-216 Molles, pp. 230-240 Week 6 Mon., Sept. 26 Tues., Sept. 27 Wed., Sept. 28 Fri., Sept. 30 LABORATORY 6: Week 7 Mon., Oct. 3 Tues., Oct. 4 Wed., Oct. 5 Fri., Oct. 7 LABORATORY 7: Molles, pp. 228-230 Molles, pp 350-376 NO CLASS: PRESIDENTIAL INAUGURATION NO CLASS: FALL RECESS NO CLASS: FALL RECESS PRELIMINARY EXAMINATION II Week 11 Mon., Oct. 31 Tues., Nov. 1 Wed., Nov. 2 Fri., Nov. 4 Week 12 Mon., Nov. 7 Tues., Nov. 8 Wed., Nov. 9 Fri., Nov. 11 PRELIMINARY EXAMINATION III Kin Selection Worksheet Human Demography Assmt Molles, pp. 310-333 Week 10 Mon., Oct. 24 Tues., Oct. 25 Wed., Oct. 26 Fri., Oct. 28 Week 13 Mon., Nov. 14 Tues., Nov. 15 Paper Proposal NO CLASS: LABOR DAY HOLIDAY LABORATORY 3: LABORATORY 5: Week 9 Mon., Oct. 17 Tues., Oct. 18 Wed., Oct. 19 Fri., Oct. 21 Assignment(s) Due What is Ecology? Historic Principles LABORATORY 1: Week 5 Mon. Sept. 19 Tues., Sept. 20 Wed., Sept. 21 Fri., Sept. 23 Week 8 Mon., Oct. 10 Tues., Oct. 11 Wed., Oct. 12 Fri., Oct. 14 Reading(s) Competition Worksheet Plant Comm. Ecology Wksht 8/16/2011 Wed., Nov. 16 Fri., Nov. 18 Week 14 Mon., Nov. 21 Tues., Nov. 22 Wed., Nov. 23 Fri., Nov. 25 NO CLASS: THANKSGIVING RECESS NO CLASS: THANKSGIVING RECESS Week 16 Mon., Nov. 28 Tues., Nov. 29 Wed., Nov. 30 Fri., Dec. 2 Week 16 Mon., Dec. 5 Tues., Dec. 6 Wed., Dec. 7 Fri., Dec. 9 FINALS WEEK FINAL EXAMINATION: WEDNESDAY, DECEMBER 14, 2-4:30 P.M. HUMAN ANATOMY BIOL 3021 FALL 2011 INSTRUCTOR: Robert K. McAfee, Ph.D. Meyer Hall 160 Phone: office - 419.772.2762 cell - 402.802.1531 e-mail: r-mcafee@onu.edu Office hrs: Mon 11a-12noon; Wed 1-2p; Thurs 3-5p; Fri 1-2p COURSE: Lecture – MWF 2:00p to 2:50p in Science Annex (SA)105 Lab – T 12:00p to 2:45p & 3:00p to 5:45p in Meyer (MY) 129 R 12:00p to 2:45p in Meyer (MY) 129 Description – Human body systems using x-rays, MRIs, skeletal material, and cadaver dissection. Prerequisite(s) – BIOL 2001 Goals/Objectives – At the completion of the course, students will be able to: 1. Correctly locate anatomical structures on the dissected cadaver for specific anatomical regions, integrating information from the following organ systems: musculoskeletal, neural, cardiovascular, respiratory, digestive, urinary, and reproductive (as applicable in that region). 2. Correctly use anatomical terminology to label and describe structures to the satisfaction of the course instructor. 3. Describe the anatomical form of named structures seen on the cadaver, and explain the basic function of each. 8/16/2011 4. Name and define planes of section used in visualizing anatomical structures. 5. Correctly recognize and name both foramina and processes on the human skeleton and cadaver. 6. Correctly recognize and name bone matrix, skeletal foramina and processes on diagnostic films and photomicrographs. 7. Cooperate with fellow students to achieve dissection goals. 8. Application of knowledge to new employment or scholarly situations, such that students will show discipline-specific competency. Required Texts – Tortora, G. and M. Nielsen. (2009) Principles of Human Anatomy, 11th ed. Wiley, Hoboken, NJ. Tank, P.W. (2005) Grant’s Dissector, 13th ed. Lippincott, Williams & Wilkins, Baltimore, MD. Netter, F.H. (2006) Atlas of Human Anatomy, 5th ed. Novartis, East Hanover, NJ. (older editions are acceptable) SCHEDULE: Date Topic **Subject to change** Tortora __ UNIT I Lab 8/22 8/24 8/26 Directional terms & regions Introduction/Directional terms Systematics I – bone & muscle Systematics II – blood & nerves Lab 8/29 8/31 9/02 Superficial back & Shoulder Grant’s Dissector: pps 8-11; 22-24 Vertebral column & Superficial back pps 193-210; 332-34; 353-362; 598-99 Deep Back & Spinal Cord pps 379-384; 584-89 Exam Review Lab 9/05 9/07 Deep back & Spinal cord LABOR DAY LECTURE EXAM I Chapter 1 pps 140-43; 250-263; 309-315 pps 481-491; 567-578; 593-594; 604 Grant’s Dissector: pps 12-13; 15-18 UNIT II 9/09 Chest & Shoulder pps 216-19; 535-560; 497-501; 518-520; 598-99 Lab 9/12 9/14 9/16 Chest & Shoulder Brachial Plexus Arm Forearm - posterior Grant’s Dissector: pps 19-20; 25-28 pps 597-99 pps 220-21; 363-67; pps 222-25; 369-373; 497-501; 518-520; 597-99 Lab 9/19 9/21 9/23 Brachial Plexus & Arm Forearm - anterior Hand Joints Grant’s Dissector: pps 28-36 pps 222-25; 369-373; 497-501; 518-520; 597-99 pps 226-27; 374-78; 497-501; 518-520; 597-99 pps 270-73 Lab 9/26 9/28 Forearm & Hand Exam Review LECTURE EXAM II Grant’s Dissector: pps 36-48 UNIT III 9/30 Brain I pps 497-500; 515-517; 612-631 8/16/2011 Lab 10/03 10/05 10/07 Face & Neck Grant’s Dissector: pps 186-194; 196-198; 202-206; 208-210 Brain II pps 639-652 Skull/Face pps 165-192; 318-327; 497-500; 515-517 University event – NO CLASS NO LAB 10/10 10/12 10/14 Date Lab 10/17 10/19 10/21 FALL BREAK Neck Thorax I – Walls & ANS Topic Brain & Cranial cavity Thorax II - Cardiac Thorax III - Pulmonary Exam Review Lab 10/24 Thorax & Abs LECTURE EXAM III pps 328-338; 497-500; 515-517 pps 14-17; 344-48; 498; 500; 660-69 Tortora Grant’s Dissector: pps 219-227 pps 453-469; 496; 502; 514; 521-23 pps 752-767; 770-73; 532-35 Grant’s Dissector: pps 55-77; 81-84 UNIT IV 10/26 10/28 Abdomen I - Overview Abdomen II - Digestive I pps 14-19; 230-35; 340-44; 494; 503-08; 522-25 pps 494; 503-08; 522-25; 781-798 Lab 10/31 11/02 11/04 Abdomen Grant’s Dissector: pps 88-103; 105-108 Abdomen III - Digestive II pps 494; 503-08; 522-25; 798-815 Abdomen IV - Urinary pps 821-24; 836-841 Abdomen V - Male Reproductive pps 846-49; 852-59 Lab 11/07 11/09 11/11 Pelvis & Perineum Grant’s Dissector: pps 109-110;129-133 OR 143-147 Abdomen VI - Female Reproductive pps 860-62; 866-875; 885-88 Exam Review LECTURE EXAM IV UNIT V Lab 11/14 11/16 11/18 Anterior & Medial Thigh Post-abdomen & Pelvis Pelvis & Perineum Ant & Med thigh Grant’s Dissector: pps 151-159 pps 230-35; 346-47; 385-88; 509-512; 600-01; 664-66 pps 349-352; 600-02 pps 236-38; 388-390; 392-95; 509-512; 526-29; 600-01 NO LAB 11/21 Gluteal 11/23 NO CLASS – THANKSGIVING 11/25 NO CLASS – THANKSGIVING pps 230-35; 385-395; 602-03 Lab 11/28 11/30 12/02 Gluteal & Posterior lower limb Grant’s Dissector: pps 159-167; 169-172 Posterior thigh & Popliteal fossa pps 236-38; 390-97; 509-512; 526-29; 602-03 Ant & Lateral Leg pps 239-241; 398-403; 509-512; 526-29; 602-03 Posterior Leg pps 239-241; 398-404; 509-512; 526-29; 602-03 Lab 12/05 12/07 Anterior & lateral Leg; Foot Foot Joints Grant’s Dissector: pps 172-180 pps 242-44; 405-409; 509-512; 526-29; 602-03 pps 274-282 8/16/2011 12/09 Exam Review 12/12 FINAL EXAM @ 2-4:30p in SA 105 GRADING: Exams: Exam I 60 Exam II 100 Exam III 75 Exam IV 65 Exam V 100 exam total: Quizzes (12 @ 15pts each) Attendance Misc. Assignments/Pop Quizzes Total points = 400 180 70 50 700pts Grading Scale – A = 90%-100%, B = 80%- 90%, C = 70% - 80%, D = 60% - 70%, F= Below 60% Lecture Exams – There will be 5 exams covering one unit of material for the semester. The exams, including the final, are not comprehensive, although material and concepts you learn early in the course will still be applicable throughout the remainder of the class. Exam format can include a mixture of the following items: multiple choice, short answer, fill-in the blank, and/or matching. It is ill-advised that you miss any of the exams but should the circumstance occur the make-up policy is that the student will be required to take an exam in the format of all essay. Lab Quizzes – There will be 13 quizzes that will cover material from the previous week’s dissection, as well as at least two questions regarding that current week’s dissection (i.e. material from the dissector readings). Quiz format will be a miniature lab practical, requiring you to answer questions at stations from bones, models, x-rays or the cadavers. Your lowest quiz score will be dropped/discarded for calculating final grades. Attendance – Attendance at ALL lectures and labs is expected. Given the importance of lab, specific points for attendance will be taken from each lab (5pts per week). The only excused absences are illness (requires a note from the nurse or a doctor) or a University-sponsored event. Unexcused Absences greater than three in a semester may lower your final grade. If you are ill, and must miss class, you must contact the instructor before the next class. If you must miss class due to a University-sponsored event, you must contact me before you miss class so that arrangements can be made for any missed work. Any late work from an unexcused absence will be assessed a 10% penalty for each day it is late. Academic Conduct – As indicated in the Student Handbook (Appendix D) [Code of Student Academic Conduct], any academic misconduct as described in the handbook, including but not limited to plagiarism, cheating, and/or improper collaboration on assignments will result in a zero for that assignment, or other sanctions determined by the instructor based on the severity of the offense. A second offense will result in failure of the course, and notification of both the Dean of the College in which the infraction occurred, and the Dean of the College of the student’s registration. 8/16/2011 POLICIES & PROCEDURES: The cadavers you are going to work on represent the remains of individuals who have donated their bodies for educational purposes. It is an unusual and valuable privilege to be allowed to do what you are about to do. It is absolutely imperative that you afford these cadavers, and all other material that represents the remains of human beings, the appropriate high degree of respect. In order to help ensure proper behavior in the lab, certain rules have been established to which you will adhere: 1. Safety and respect come first and foremost! 3. No food or drink should be taken into the lab. 4. No cameras or other photography are allowed in the laboratory at ANY time. 5. No cell phones usage during either lecture or lab. Phones should either be turned off or on silent pager mode. Failure to do so will result in a loss of 5pts per incidence after an initial warning. Recording of lectures is also not allowed unless permission has been given by the instructor. 6. No cadaveric or skeletal material should ever be taken outside of the lab. 7. Bring your dissector and atlas to every lab. 8. Appropriate clothing, including shoes that cover the entire foot are required in the lab (Sandals, shorts, and inappropriate t-shirts are not allowed). You must wear your lab coats every time you enter the lab or you will be asked to leave, AND you will lose attendance points for that day. 9. Because of the presence of embalming chemicals in the dissecting lab, any student who is or believes she may be pregnant should notify an instructor. She will be advised to consult with her physician about whether or not to proceed with the course. 10. ALL tools should be cleaned and properly stored at the end of the dissection day! MEDICAL PHYSIOLOGY I – BIOL 3241 (Formerly BIOL 324 and Part of BIOL 326) FALL SEMESTER 2011 8/16/2011 Course Description: The first in a sequence of two courses (continued in Medical Physiology II), that provides an in-depth survey of the physiology of human systems. The course involves both a lecture and laboratory component that will emphasize integration of parameters from all levels of tissue and organ system function. Where possible, it will include comparisons across various vertebrate and invertebrate species; as well as scenarios that require problem solving and practical application of physiological principles. Topics covered in this course include: functional significance of features associated with transport across the plasma membrane, principles associated with excitable cells, functional organization of the nervous system including specific sensory pathways and somatic and autonomic motor output, organization and activation of skeletal muscle, and endocrine and reproductive structures and functions. The laboratories are designed to enhance the understanding of physiological principles presented in lecture and will incorporate some classical experiments pertaining to neural, skeletal muscle, and endocrine physiology. Students will also work in teams to conduct literature reviews and design research proposals that upon approval by the appropriate university committee will be conducted in the second semester (in Medical Physiology II). Course Prerequisite: Biology III (formally BIOL 123) and one year of chemistry Lecture Instructors: Dr. Vicki Motz: ME 163, x2063 Dr. Rema Suniga: ME 161, x2323 Dr. Nancy Woodley: ME 162, x2326 Office hours: to be announced * other times by appointment Laboratory Instructor: TBA * Topic areas will be divided such that one instructor will cover all topic area(s) for a given five week period. Questions pertaining to topics covered during a given five week period should be addressed with the corresponding instructor for that period. Required Materials: 1. Human Physiology, Rhodes and Pflanzer, 4th ed., Thomson 2. Medical Physiology I Laboratory Manual and Work Book, Motz, Suniga and Woodley, 2011, ONU (available from the instructor on the first day of the quarter) Course notes/outlines: Available on Dr. Suniga’s P:drive; Dr. Woodley’s web page: http://www2.onu.edu/~nwoodley and on WebCT Course Schedule: Lectures: MWF 1:00-1:50 PM, MT 112 Lab: R- sec 1, 12:00-2:45 PM; sec 2, 6:30-9:15 PM MT 107 Syllabus Agreement Form: Once you have read this syllabus, print out the syllabus agreement form (found on WebCT and Dr. Woodley’s web-page) read it over, sign it and return it, in person, to your professor prior to 4:30 PM Friday of week two. Failure to submit the syllabus agreement form by the deadline will result in the loss of weighting option for the term tests (see below). 8/16/2011 LECTURE SCHEDULE AND TOPICS (tentative!) R & P is the abbreviation for the required text. VM, RS & NW correspond to Dr. Motz, Dr. Suniga and Dr. Woodley respectively, and indicate the instructor responsible for a given topic and/or lab. Week Topic R & P Reading (Chap) Instructor 1 Introduction, Basic Principles and Plasma 1 (p. 13-18, 23-27), NW Membrane 24 (p. 762-764), 3 (p.68) Lab 1: Introduction and Literature Search Techniques (library representative) TBA 2 Plasma Membrane (cont) & 4 (p. 110-120, 123-132), NW Lab 2: Instrumentation &Data Collection for Statistical Analysis TBA Friday - Syllabus Agreement Due 3 Monday – Labor Day – No class Excitable Cells 7 (p.219-229) NW Lab 3: Frog Sciatic Nerve Action Potential TBA 4 Synaptic Transmission 7 (p. 215-216, 219, 229-247) Lab 4: Research topic exploration: computer search &consultation with instructor ALL? 5 Modifications to Synaptic Transmission & 5 (p. 163-169), 7 (p. 208-216) NW Nervous System Organization 10 (p. 340-347, 352-356) Lab 5: Electroencephalogram (EEG) TBA 6 Sensory Receptors and Information Processing 8 (p. 254-265) RS Lab 6: General Sensory Receptors, Biorhythms and Galvanic Skin Response TBA Term Test I –Friday 7 Somatosensory Pathways 8 (p. 263-268) RS Special Senses - Vision 8 (p. 273-288) Lab 7: Human Special Sensory Receptors TBA 8 October Break – No classes Mon and Tues Somatic Motor Reflexes 9 (p. 310-322) RS Lab 8: Consultation with instructor: evaluation of initial literature search and ALL? topic determination for research proposal 9 Voluntary Motor Output & 9 (p. 321-333); RS Skeletal muscle 16 (p. 480-486, 490) Lab 9: Human Reflexes, Voluntary Motor Output and EMG Recordings TBA 10 Skeletal muscle (cont) 16 (p. 496-510) RS Lab 10: Frog Nerve and Skeletal Muscle TBA 11 Endocrine Control Mechanisms 12 (p. 382-407) VM Lab 11: Term Test II? 12 Endocrine Pancreas 15 (p. 452-473) VM Hypothalamic-Pituitary Axis 13 (p. 408-422) Lab 12: Blood Glucose Regulation TBA Submission of draft of paper for review 13 Hypothalamic-Pituitary Axis (cont) VM Thyroid and Parathyroid Glands 13 (p. 422-428), 26 (p. 817-825) Lab 13: Consultation with instructor re draft research proposal ALL? 14 Adrenal Gland 14 (p. 432-451) VM Thanksgiving Break – No classes Wed, Thurs, Fri 8/16/2011 Week 15 16 Topic R & P Reading (Chap) Reproductive Physiology 15 (p. 452-473) Lab 14: Reproductive Physiology (uterine horns, pregnancy tests, sperm (sea urchins)? Reproductive Physiology (cont) Lab 15: Oral presentations, teamwork evaluation, and final research proposal due COMPREHENSIVE FINAL EXAM: During assigned date in exam period (Dec. 12-16) Instructor VM TBA VM ALL? Course Information / Policies: Lectures are provided as a guide for out of class study. Review of your notes and reading of corresponding material in the text is essential for your success in this course. Unless otherwise directed, you are responsible for all reading associated with lecture material irrespective of whether the material is fully covered in class. Laboratory manuals will be available from the instructor the first day of class. Students are encouraged to read the appropriate background material and corresponding laboratory exercises prior to each laboratory. Weekly pre-laboratory quizzes will be administered to assess your understanding of the purpose and protocols associated with the laboratory exercises. Students will work in groups, with three to four students per group. During the lab, record all data and observations accurately. Although the physical collection of data may not take the entire laboratory period, students are strongly encouraged to discuss and complete the questions pertaining to the laboratory prior to leaving. If you find that you are having problems with the course material, be certain to contact your instructor. Help is readily available BUT it is solely your responsibility to seek help if required. The material that will be covered is inherently challenging and you may find additional discussions helpful. Cheating, plagiarism, and other unethical activities are absolutely discouraged as any one of these will cause a student a "zero" grade for the particular quiz / exam / lab report and the incident will be brought to the attention of the Department Chair, the College Dean and the Dean of Students. A second offense will result in a failing grade for the course. Attendance: Attendance at all lectures and laboratories is expected. You should notify your instructor if you plan to be absent from class. You will be responsible for making up any lecture material missed. Make-ups for missed labs are at the discretion of the instructor and must be arranged with the instructor. Learning Assessment and Grades: Although each instructor will be responsible for 5 weeks of the course content and will write the tests and quizzes pertaining to the material that they covered; the content corresponding to the testing material will be agreed upon by all the instructors. Questions pertaining to the course material should be addressed to the instructor responsible for that material. A total of 6 quizzes (2 per instructor) will be given. The quizzes will consist of fill-in-the blanks and short answer questions based on material covered by the instructor responsible for that topic area. There will be no "make-up" for missed quizzes except under extenuating circumstances. In the latter case, arrangements must be made with the appropriate course instructor within one week of missing the quiz. 8/16/2011 Students will be expected to submit their own scenarios for potential use in classroom discussions. Each submitted scenario (no more than two per week) must include a well articulated solution and is worth 0.5 points to a maximum of 8 points. The first term test will include all lecture and related laboratory material presented in the first five weeks, and the second term test will cover all lecture and related laboratory material presented in the second five weeks. The final exam will consist of two parts. The first part will have the same point value as the previous term tests and will cover material presented the last 5 weeks of the semester; the second part will be comprehensive covering all material presented, including laboratory content, during the entire semester unless otherwise specified. The format of the term tests and final may include fill-in-the-blank, short answer, and essay questions. Laboratory quizzes will be given prior to conducting laboratory exercises to assess understanding of what scientific principal is being investigated, what data is being collected and what protocol is being followed. Students in the laboratory will work in teams to complete laboratory exercises, conduct literature reviews, design solid research proposals, and present the proposals in both oral and written formats. The research proposal must satisfy the requirements stated in the lab manual (see “Guidelines for: Research Proposal, IRB or IACUC Approval, Budget Allocation and Oral Presentation”) and must be designed such that, given approval from the appropriate university committee, research collection can begin in the second semester (Medical Physiology II). The division of labor as to who writes up the proposal, researches the background, comes up with the ideas, etc. can be decided among the group members. However, each member is expected to be familiar with all aspects of their proposal. The grade assigned for the topic selection, final research proposal, and oral presentation will be based on the scores achieved using the grading rubrics in the appendix of the lab manual for the oral and written information presented by the group and all individuals within the group will be assigned the same grade. In addition, each team member will assign a teamwork score (maximum=5) for each member of the team on his/her performance as a team member (see teamwork grading rubric in the appendix of the lab manual). Each member’s teamwork score for the course will be the average of the teamwork scores assigned to them by their group members. The course grading scheme is as follows: Item Six quizzes (25 points each) Term test 1 (first 5 wks of material) Term test 2 (second 5 wks of material) Final exam: Part One (last 5 wks of material) Final exam: Part Two (comprehensive portion including laboratory content) Scenarios (0.5 points each) Topic selection Pre-lab quizzes (1 point each) Research Proposal: Abstract (10 pt), Introduction (10 pt), Methods (10 pt), Budget (5), Predicted Outcomes (4 pt), Literature Cited (5 pt), Spelling/Grammar (4 pt), Completed IRB or IACUC forms (4), Overall impression (4) Oral Presentation Team Work Score Total Points A > 585 points B > 520 points C > 455 points D > 390 points F < 390 points. Points 150 100 100 100 100 8 5 10 56 16 5 650 Note: As long as the signed syllabus agreement form is received prior to the deadline, the point distribution of the term tests will automatically be weighted. The lower term test score will be weighted 8/16/2011 to half the original value and the higher score will be weighted to 1.5 times the original value so that the total point value for the two tests remains at 200 points. Grading Policy: Other than adjustment for errors in addition, quizzes and tests written in pencil will not be re-graded. Adjustments for errors in addition, or credit not given in tests and quizzes, need to be brought to the attention of the appropriate instructor within one week following the return of the quiz or test. Since the weight distribution of the term tests is automatically adjusted to benefit the student, there will be NO CURVING or ADJUSTING of grades! You should feel free to inquire about, or discuss, your grade with your instructor at any time (within reason!) during the semester. Course Learning Objectives: (Corresponding University General Education Learning Outcomes (LO) are in parentheses) At the end of the course, the student will be able to: 1. List and describe the structure and function of the basic components of each organ system at the organ, tissue and cellular levels utilizing an integrative functional approach. (LO 3) 2. Apply the basic principles of cellular, neuromuscular and endocrine physiology to effectively interpret and answer scenario-based essays. (LO 2, 3) 3. Demonstrate proficiency in the safe use of laboratory equipment pertaining to data collection (LO 3) 4. Use appropriate statistical tests and graphical representations to assist in presentation and interpretation of data collected in laboratory exercises (LO 1, 2, 3) 5. Apply literature-based information and scientific process to the creation and design of a potential research project (LO 1, 2, 3, 6) 6. Convey the plan and significance of the proposed research project in both oral and written formats (LO 1) 7. Develop the ability to work together collaboratively (LO 1, 6) Cell Biology, Biology 3511 Course Instructor: Linda Young Room 125 Mathile Hall (419) 772-2438 l-young@onu.edu Office hours by appointment and 2:00 pm M-F. Text Book: Molecular Biology of the Cell by Alberts et. al. 5th edition, Garland Science Publishers. Website: All related course materials can be referenced at http://www2.onu.edu/user/fs/lyoung or the P drive. Course Motto: “If your don’t have time to do it right, when will you have time to do it over?” Course Goals: During the course, students will be expected to integrate data regarding cell structure and function to develop an understanding of 8/16/2011 eukaryotic cells as dynamic entities. This will be accomplished by reviewing key studies, analyzing light and electron micrographs, investigating current topics in cell biology and covering traditional materials in lecture. Learning Objectives: To facilitate your studying for graded assignments, I will often reference specific learning objectives. Please review the appropriate objectives as we begin each new unit. to: At the completion of this course, students will be able A. Protein Unit Objectives: 1. State and recognize all 20 amino acids and indicate their chemical nature. 2. Identify and discuss the 4 levels of protein structure. 3. Discuss the importance of the evolution of protein structure, the role of protein domains, domain shuffling, protein modules, subunit assembly mechanisms, and how this correlates with new protein functions. 4. Cite multiple examples of protein-ligand binding as it relates to protein function. 5. List the factors influencing protein-ligand affinity and binding strength. 6. Calculate the Ka for a given protein and its ligand and explain the significance of this relationship. 7. Explain the general mechanism by which an enzyme is able to catalyze a chemical reaction and apply this concept to the specific activity of lysozyme. 8. Diagram and discuss the Michaelis-Menten kinetics of an enzyme-mediated system and relate this concept to a Lineweaver-Burk plot. Define all parameters involved. 9. Calculate enzyme efficiency. 10. List and explain 4 mechanisms to increase enzyme efficiency. 11. Compare and contrast the 7 mechanisms of enzyme pathway regulation. 12. Using I/O proteins, assembly factors, motor proteins and membrane-bound transporters explain how allosteric conformational changes permit function. 13. Outline how a combinatorial regulatory code can impact protein activity. B. Membrane Unit Objectives: 1. Diagram and label a plasma membrane as described by the Singer-Nicholson Hypothesis and state the function of each component. 2. Identify the 4 most prevalent phospholipids found in the plasma membrane and discuss the factors influencing their tremendous diversity. 3. Discuss phospholipid movement within the plasma membrane. 4. Explain the factors influencing membrane fluidity. 5. Compare and contrast the lipids of the inner and outer plasma membrane leaflets and apply your knowledge of these structural differences to their respective functions. 6. State the 4 major functions of glycolipids. 7. Diagram the various insertion methods of transmembrane and peripheral proteins. 8. Distinguish between glycoproteins and proteoglycans. 9. Discuss the nature and potential functions of integral membrane proteins. 10. In terms of structure and function, compare a β-barrel with a multipass helical transmembrane protein. 11. List the components and functions of the glycocalyx. 8/16/2011 12. Explain the mechanism of detergent action for integral protein extraction and the usual protocol for protein separation and isolation. 13. Compare and contrast FLIP and FRAP, indicating how each effectively measures lateral diffusion in the membrane. 14. State 4 ways to “anchor” a protein within a fluid membrane. 15. Diagram and label the spectrin-based (cortical) cytoskeleton of the inner leaflet of the RBC. C. Transport Unit Objectives: I. Membrane Transport: 1. Link the features of membrane-soluble molecules with their ability to cross a membrane. 2. Distinguish between passive and active transport. 3. Graphically delineate between simple diffusion and facilitated diffusion. 4. Explain ionophore impact on membrane transport. 5. Diagram and explain the operation of the following pumps: a. Sodium-glucose transporter. b. Lactose permease. c. Sodium-Hydrogen Exchanger d. Sodium-driven Chloride-Bicarbonate exchanger. e. Sodium-independent Chloride-Bicarbonate exchanger. f. Calcium ATPase. g. Sodium-Potassium pump. 6. Distinguish between each of the following transport concepts: a. Primary active transport versus secondary active transport. b. Uniports, Symports, and Antiports. c. 3 Classes of ATP-driven pumps and their respective mechanisms of action. 7. Recall the Nernst equation and use it to calculate the equilibrium potential of an indicated ion. 8. Compare different mechanisms employed by various cell types to regulate tonicity. 9. Compare and contrast the operation of voltage-gated, mechanically-gated, and ligand-gated channels using a specific example for each. 10. Explain how the structure of each the following channels confers selectivity: a. Bacterial Potassium channel. b. Chloride channel. c. Aquaporins. 11. Apply your knowledge of membrane transport mechanisms to explain the development, propagation, and transmission of an action potential. II. Transport between Cellular Compartments: 1. Compare and contrast the evolution of cellular compartments via the Autogenous and Endosymbiont Hypotheses. 2. Identify the 3 principle mechanisms by which proteins are transported between compartments. 3. Diagram, label, and explain the following transport mechanisms, their regulation, and directionality. Be able to connect organelle structure 8/16/2011 4. 5. 6. 7. 8. 9. III. with its specific transport process and its ultimate function. a. Nuclear import/export b. Movement of cytosolic proteins into the mitochondrial matrix, cristae, and mitochondrial space and insertion of mitochondrial encoded proteins into the inner membrane. c. Movement of cytosolic proteins into the chloroplast stroma, thylakoid membranes, and inner chloroplast envelope. d. Movement of cytosolic proteins into peroxisomes. Compare and contrast a signal sequence versus a signal patch. Compare and contrast post- versus co-translational ER transport. Outline the mechanism by which a single pass versus a multipass integral protein is inserted in the ER membrane. State 3 functions of a GPI anchor. Describe the process of protein glycosylation in the ER, its effect on protein folding, and the fate of mis-folded proteins. Explain the process of lipid bilayer synthesis. Intracellular Vesicular Transport: 1. Structurally and functionally distinguish between the 3 major classes of coated vesicles and outline the process by which loading and formation occur. 2. Describe the structure of Retromer and indicate its function. 3. Diagram and explain guided vesicle targeting by integrating your knowledge of Rab protein function and SNARES. 4. Integrate the concepts of COPII vesicle transport, COPI vesicle retrieval, oligosaccharide processing, transport through the Golgi, signal-mediated vesicle diversion and exocytosis to account for the secretion of a functional glycoprotein. 5. Identify the major goals of glycosylation. 6. Explain how lysosomes and vacuoles function and their mechanisms for targeting cargo. 7. Chemically and developmentally distinguish between complex and high mannose oligosaccharides. 8. Compare and contrast phagocytosis and pinocytosis. 9. Briefly describe the process of transcytosis and its cellular importance. 10. Describe how cargo is sorted in preparation for exocytosis and explain the mechanism of secretory vesicle priming. D. Energy Transducing Organelles Unit Objectives: 1. Thoroughly describe the ultrastructure of a mitochondrion and integrate each aspect with its role in aerobic respiration. 2. Accurately diagram aerobic respiration identifying all intermediates, enzymes, and protein complexes involved. 3. In detail, outline the structure and function of ATP Synthase. Relate your outline to the role of this enzyme in the mitochondrion and chloroplast. 8/16/2011 4. Thoroughly describe the ultrastructure of a tracheophyte chloroplast and integrate each aspect with its role in non-cyclic photophosphorylation, cyclic photophosphorylation, Carbon fixation, and photorespiration. 5. Accurately diagram non-cyclic and cyclic photophosphorylation identifying all intermediates and complexes involved. 6. Accurately diagram the Calvin-Benson Cycle in a C3 plant and then compare and contrast it with Carbon fixation in C4 and CAM plants by specifically indicating the selective advantages conferred by these photosynthetic modifications. 7. Compare and contrast amylose and amylopectine. 8. Diagram the biosynthetic reactions of: sucrose, starch, and chlorophyll a. 9. Relate the structure of chlorophyll a to its function. 10. Identify the similarities and differences in ATP production between mitochondria and chloroplasts. E. Cellular Communication Unit Objectives: 1. Identify mechanisms of local and long distance communication mediated by extracellular signaling molecules. 2. Compare and contrast target responses to identical signal molecules binding to different receptor types versus those signal molecules binding to identical receptors on different cell types. 3. Explain the mechanisms of action for intracellular signaling mediated by small, hydrophobic molecules and by ligand-activated nuclear receptors. 4. Identify the 3 major classes of cell-surface receptor proteins and the 2 principle means by which they relay signals to the cell interior. 5. Identify the 3 principle strategies employed by cells to achieve signal specificity in complex systems. 6. Explain how cooperative binding influences signal response rate. 7. Identify and diagram 5 mechanisms of signal desensitization. 8. Compare and contrast “smooth” vs. “switch” signal responses and discuss why it is often difficult to determine which process a cell is utilizing. 9. Distinguish between positive and negative feedback loops and indicate their importance in signal response regulation. 10. Diagram and explain a G-protein linked receptor response mediated by a cAMP second messenger system. 11. Diagram and explain a G-protein linked receptor response mediated by IP3 /DAG as second messengers, including the roles played by Calcium, Calmodulin, and Ca2+/CaM-activated kinases. 12. Identify 6 classes of enzyme-linked receptors. 13. Using receptor tyrosine kinase as an example, illustrate and explain enzyme -mediated signal transduction involving Ras as a second messenger, the conversion of short to long-term signaling and the impact at the molecular level. 14. Briefly summarize the following major plant signaling mechanisms: cell differentiation, ethylene response, auxin response, basipetal polar auxin transport and its role in root gravitropism, and PC response. F. Cell Cycle/Apoptosis Unit Objectives: 1. Diagram the cell cycle and describe the events associated with each phase. Specify the significance of Go. 8/16/2011 2. List the major features of the cell cycle control system and identify its 3 checkpoints. 3. Outline the process of cyclically activating/inactivating Cdk’s to regulate the cell cycle’s primary control system through all checkpoints. Indicate the specific functions associated with each of the 4 major cyclin classes. 4. Diagram and explain the activation of a Cdk. In addition to changes in cyclin concentrations, describe the following mechanisms of regulating Cdk activity by providing an appropriate example: Wee 1 Kinase, Cdc25 Phosphatase, Cdk Inhibitor Protein binding, Ubiquitin-mediated proteolysis (SCF and APC/C), and transcriptional changes. 5. Explain the regulatory mechanism of the S Phase which permits accurate DNA duplication and the production of cohesive sister chromatids. 6. Diagram, label, and explain the events of the 6 mitotic phases. 7. Describe how the cell cycle control system governs the 2 major parts of mitosis. 8. Compare and contrast the details of cytokinesis in animal versus plant cells. 9. State the normal roles of apoptosis. 10. Diagram and discuss the extrinsic and intrinsic pathways of apoptosis. 11. Diagram and describe the intracellular and extracellular mechanisms of caspase activation and compare with the mechanisms used by stressed/damaged cells. 12. Identify the roles of Bcl-2 proteins and Inhibitors of Apoptosis (IAP’s) in apoptotic regulation. G. Laboratory Objectives: 1. Accurately analyze light and electron micrographs of eukaryotic cells and their components. 2. Correctly perform basic laboratory techniques associated with cell biology research, including but not limited to: organelle isolation, light microscopy, fluorescence microscopy, determination of enzyme kinetics, electrophoresis, western blotting, protein quantification, fluorescent labeling, accurate pipetting, serial dilution, cell population quantification, pigment extraction with chromatographic separation, cell isolation, measuring pH, and commercial antibody-based techniques such as OIA, EIA, and agglutination assays. 3. Explain the principle behind procedures performed in the laboratory and apply them to new experimental scenarios. 4. Analyze data obtained from experimentation and use it to draw conclusions, develop alternate hypotheses, and/or trouble shoot protocols. 5. Adhere strictly to all safety policies required to work in a level 2 biohazard laboratory. Learning Assessment and Grading: Quiz 50 Quiz 40 Quiz 40 Quiz 40 1 (Chapters 1 & 2 Review) 2 3 4 8/16/2011 Protein Modeling Misc. Assignments 25 30 Lecture Exam 1 100 Lecture Exam 2 100 Lecture Exam 3 100 Current Events Presentation/Abstract 25 Final Exam 200 Total Points 720 All graded assignments will be announced and specific requirements/formats reviewed with the class. The final examination will consist of 125 comprehensive points to review material from the first three units and 75 points to emphasize the material in the last unit. Your final exam is scheduled for Friday, December 16, 2011 at 10:45 a.m. Final grades will be assigned based upon the total number of points accumulated by the successful completion of assignments. The grading scale below will determine the course grade assigned: A=90-100% B=80-89% C=70-79% D=60-69% F=0-59% Attendance Policy: The student is expected to attend all lecture classes, laboratory exercises, and graded assignments. Attendance points are not assigned in this course, but since lecture material, in addition to text book material, is covered on exams, absences are likely to adversely affect performance. Missed exams/quizzes cannot be made-up without acceptable, written verification of the absence. Academic Misconduct Policy: Academic misconduct of any type (see the Student Handbook) will not be tolerated. The first incident will result in a “zero” for the assignment. A second incident will cause an “F” to be assigned for the course grade. Prerequisites: One year of biology, one year of chemistry, and either Biology 210 or 217. Junior/senior status is strongly recommended. Cell Phone Policy: Unless you are a first responder, you should turn your cell phone off during class. Should you have a valid reason to keep your phone on, please discuss this with me prior to lecture/lab. Texting during class time is not permitted. Disruption of class with cell phone use will result in a 10 point penalty for each incident. Text Book Reading Assignments Part I Introduction to the Cell Chapter 1 Cells and Genomes 1- 8/16/2011 44 Universal features of cells on Earth Diversity of genomes and the tree of life Genetic information in eukaryotes (Independent Assignment) Chapter 2 Cell Chemistry and Biosynthesis 45124 The chemical components of a cell Catalysis and use of energy by cells How cells obtain energy form food (Independent Assignment) Chapter 3 Proteins 125-193 The shape and structure of proteins Protein function Part IV Internal Organization of the Cell Chapter 10 Membrane Structure 617-650 The lipid bilayer Membrane Proteins Chapter 11 Membrane Transport of Small Molecules and the Electrical Properties of Membranes Principles of membrane transport Transporters and active membrane transport Ion channels and the electrical properties of membranes Exam I Chapter 12 651-694 Intracellular Compartments and Protein Sorting 695-748 The compartmentalization of cells The transport of molecules between the nucleus and cytoplasm The transport of proteins in mitochondria and chloroplasts Peroxisomes The endoplasmic reticulum Chapter 13 Intracellular Vesicular Traffic 749-812 The molecular mechanism of membrane transport 8/16/2011 and the maintenance of compartmental diversity Transport from the ER through the Golgi apparatus Transport from the trans Golgi network to lysosomes Transport into the cell from the plasma membrane: endocytosis Transport from the trans Golgi network to the cell exterior: exocytosis Chapter 14 The mitochondrion (review pp. 95-100) Electron transport chains and their proton pumps Chloroplasts and photosynthesis The genetic systems of mitochondria and plastids The evolution of electron transport chains Energy Conservation: Mitochondria and Chloroplasts 813-878 Exam 2 Chapter 15 Signaling Signaling Signaling Signaling Mechanisms of Cell Communication 879-964 General principles of cell communication through G-protein coupled cell surface receptors through enzyme-coupled cell surface receptors pathways that depend on regulated proteolysis in plants Chapter 16 Exam 3 The Cytoskeleton How cells regulate their cytoskeletal filaments Molecular motors The cytoskeleton and cell behavior Chapter 17 965-1052 The self-assembly and dynamic structure of cytoskeletal filaments The Cell Cycle An overview of the cell cycle The cell cycle control system (S Phase, Mitosis, Cytokinesis) Chapter 18 1053-1114 Apoptosis 1115-1129 Part V Cells in Their Social Context 8/16/2011 Chapter 19 Cell Junctions, Cell Adhesion and the Extracellular Matrix 1131-1204 Cadherins and cell-cell adhesion Tight junctions and the organization of epithelia Passageways from cell to cell: gap junctions and plasmodesmata The basal lamina Integrins and cell-matrix adhesion The extracellular matrix of animals The plant cell wall 8/16/2011 Chemistry 1711 / 1811 Instructors: Dr. Susan E. Bates Dr. Tevye C. Celius Dr. Jeffrey A. Gray Dr. Trilisa M. Perrine Dr. Christopher E. Spiese Dr. Bradley M. Wile Syllabus Fall 2011 www2.onu.edu/~s-bates webct-new.onu.edu www2.onu.edu/~j-gray webct-new.onu.edu webct-new.onu.edu webctnew.onu.edu s-bates@onu.edu t-celius@onu.edu j-gray@onu.edu t-perrine@onu.edu c-spiese.1@onu.edu b-wile@onu.edu ME 264 ME 268 ME 263 ME 267 ME 253 ME 265 772-2341 772-3020 772-2337 772-2340 772-2365 772-2986 Texts and General Chemistry, Ebbing and Gammon, 9th ed., Houghton-Mifflin (2009) Materials: Introductory Chemistry Laboratory Manual 2011-12, ONU (2011) Darling model kit, grid-lined lab notebook, and non-programmable scientific calculator some individual instructors may also require an audience response device ("clicker") Course Plan: Assignments: Prepare for each class and lab by reading ahead. Prepare for quizzes and exams by completing all assigned homework problems; these will not be collected, but you are expected to seek help from your instructor when you have difficulty. Plan to read and do chemistry homework daily. Expect to learn and apply concepts rather than simply memorizing. Testing: Each instructor will designate one meeting period a week for review and quizzes. Quizzes will have a 30minute time limit. Hour exams will be administered on Thursday evenings at 7 PM (see dates below). A student may be excused from a scheduled exam time due to serious illness, emergency, or conflict with an authorized ONU function if the instructor is notified in advance; exams must then be completed within the next three days. Per departmental policy, exams will never be administered early. Exam room assignments will be announced in class. All exams are cumulative. Unless otherwise noted by your instructor, your class will not meet on the remaining Thursday evening periods. Grading: Activity % of Total Letter % Range Chapter Homework Problems 1. Chemistry and Measurement 37-53 (odd), 61, 65, 67, 81-85 (odd), 91, 99, 101, 111, 113, 133 2. Atoms, Molecules, and Ions 21, 37-53 (odd), 57-69 (odd), 75-101 (odd), 107-111 (odd), 119-125 (odd) 3. Calculations with Chemical Formulas and Equations 27-83 (odd), 91, 95, 97, 103, 107, 117, 119 4. Chemical Reactions 29-41 (odd), 42, 43-73 (odd), 78, 80, 84, 100, 108, 110, 112, 118, 124, 140, 146 5. The Gaseous State 37, 39, 45, 48, 51, 55, 57, 60, 62, 67, 73, 76, 77, 80, 81, 84, 86, 87, 89, 92, 96, 98, 101, 107, 112, 114, 115, 119, 126, 129, 145 6. Thermochemistry 51-85 (odd), 88, 94, 96, 98, 100, 102, 110, 112, 114, 116, 118, 140 7. Quantum Theory of the Atom 35, 37, 43-59 (odd), 63, 67, 68, 70, 72, 74, 81, 82, 87, 88, 89, 107 8. Electron Configurations and Periodicity 41, 43, 47-55 (odd), 61-71 (odd), 75, 81, 83 9. Ionic and Covalent Bonding 29, 31, 35-109 (odd) 10. Molecular Geometry and Chemical Bonding Theory 33-63 (odd), 77, 79, 81 23. and 24. (selected topics) TBA 7 of 9 Quizzes Exam 1 (9/22/11) Exam 2 (10/27/11) Exam 3 (12/1/11) Laboratory Class Participation Final Exam (TBA) 20% 15% 15% 15% 10% 5% 8/16/2011 20% A 89 - 100 % B 79 - 88 % C 65 - 78 % D 50 - 64 % F < 50 % Total 100% Attendance: Integrity: Attend lectures and labs regularly and be on time; frequent absences will bring down a borderline performance. No make-up quizzes will be administered for any reason, so a missed quiz will be one of those dropped. However, if a student misses two or more regular quizzes, (s)he may earn replacement credit for one quiz score by completing a common, comprehensive replacement test during the last week of classes. A lab may only be made up during the same week; you must arrange this with another lab instructor. A missed lab will earn a score of 0, and more than three unexcused absences from the lab will result in a failing grade for the course. In case of serious illness, emergency, or conflict with an authorized University function, please contact your instructor as soon as the conflict is known. Students in this course are expected to adhere strictly to the ONU Student Code of Academic Conduct (see ONU Student Handbook). General Education This course has been tagged to fulfill the general education requirement for scientific Information: literacy. See the Chem 1711 Laboratory Syllabus for details on artifact generation and collection. Week Date 1 Aug.23–25 2 Aug. 30 – Sept. 1 3 Sept.6–8 4 Sept. 13 – 15 5 Sept. 20 – 22 6 Sept. 27 – 27 7 Oct.4–6 8 Oct. 12 –13 9 Oct. 18 –20 10 Oct. 25 –27 11 Nov.1–3 12 Nov.8–10 13 Nov.15–17 14 Nov. 22 Nov. 23 – 24 15 Nov.29–Dec.1 16 Dec.6–8 Oct. 11 Notes: Experiment # 1 23 456 78 9 10 11 7 15 Assignment No Lab Meeting Check In Introductory Laboratory (also read Lab Manual Appendices A, B, C) Identification of Unknown Solutions Chemical Measurements (also read Lab Manual Appendices C, D, E) Synthesis of a Cobalt Salt Reaction Stoichiometry Redox Titration No lab meeting – Fall Recess Copper Compounds Thermochemistry (also read Lab Manual Appendix F) Gas Laws Periodic Table Worksheet (Bring your textbook to lab) Atomic Spectroscopy Spectrophotometry Determination of Iron in Tablets Copper Compounds No Lab Meeting - Thanksgiving Recess Molecular Models Check Out Chemistry 1711/1811 General Chemistry 1 Laboratory Syllabus Fall Semester 2011 1. Come prepared each week for lab. Study the assigned lab procedure and relevant appendices. Obtain any needed table data (molar masses, etc.). Make procedural notes and data/observation tables in your notebook. All of this should be done before coming to the lab. The instructor may give a quiz at the start of the lab session. 2. Write down all primary data and observations directly in your lab notebook, not in your manual, report sheet, or extra papers. Also in the notebook, answer questions that are asked in the manual procedures and show calculations needed for the report sheet. Notebooks will be graded weekly (1 point per week). 3. A completed report sheet for the experiment should be returned to the TA at the end of the lab period unless otherwise notified. Your report grade will be based on the correctness of any calculations, including significant figures, the quality of your results, and the answers to any questions. 4. Safety goggles are to be worn in the laboratories at all times, unless the instructor specifically notes otherwise (e.g., during prelab lectures or quizzes). In particular, if any student is conducting an experiment, all students in the lab must have on goggles. 5. Lab quizzes will be given throughout the semester at the instructor’s discretion. A missed lab period, report, and quiz will be counted as “0”. If you must miss a lab for medical reasons or for a University- approved function, contact your instructor before the lab and arrange 8/16/2011 to make up the lab that week in another section. Labs cannot be made up in weeks following their assigned time. More than 3 unexcused absences from the lab will result in a failing grade for the semester. 6. Points earned in lab make up 10% of your Chem 1711 grade. Lab point distribution is as follows: Lab Notebooks Report Sheets Lab Quizzes 60 points Total 200 points 7. If you are using Chem 1711 to fulfill the general education requirement for scientific literacy, you must generate and submit an artifact to be assessed by your instructor. The artifact for this course consists of 4 documents - the completed report sheets for experiments 4, 5, and 6 (the series of experiments involving cobalt (II) oxalate dihydrate synthesis and analysis), plus an additional exercise available from your lab instructor during week 9 of the semester. The artifact must be submitted as one complete packet to your lab instructor no later than Friday, Nov. 4. 12 points 128 points Chemistry 1721 / 1821 Instructors: Dr. Susan E. Bates Dr. Nicole Dickson Dr. Trilisa M. Perrine Dr. Christopher E. Spiese Dr. Bradley M. Wile Syllabus Spring 2012 www2.onu.edu/~s-bates webct-new.onu.edu webct-new.onu.edu webct-new.onu.edu webct-new.onu.edu s-bates@onu.edu n-dickson.1@onu.edu t-perrine@onu.edu c-spiese.1@onu.edu b-wile@onu.edu ME 264 ME 246A ME 267 ME 253 ME 265 772-2341 772-2258 772-2340 772-2365 772-2986 Texts and General Chemistry, Ebbing and Gammon, 9th ed., Houghton-Mifflin (2009) Materials: Introductory Chemistry Laboratory Manual 2011-12, ONU (2011) Darling model kit, grid-lined lab notebook, and non-programmable scientific calculator some individual instructors may also require an audience response device ("clicker") Course Plan: Assignments: Prepare for each class and lab by reading ahead. Prepare for quizzes and exams by completing all assigned homework problems; these will not be collected, but you are expected to seek help from your instructor when you have difficulty. Plan to read and do chemistry homework daily. Expect to learn and apply concepts rather than simply memorizing. Testing: Each instructor will designate one meeting period a week for review and quizzes. Quizzes will have a 30minute time limit. Hour exams will be administered on Thursday evenings at 7 PM (see dates below). A student may be excused from a scheduled exam time due to serious illness, emergency, or conflict with an authorized ONU function if the instructor is notified in advance; exams must then be completed within the next three days. Per departmental policy, exams will never be administered early. Exam room assignments will be announced in class. All exams are cumulative. Unless otherwise noted by your instructor, your class will not meet on the remaining Thursday evening periods. Grading: Activity % of Total Letter % Range Chapter Homework Problems 11. States of Matter; Liquids and Solids 37, 39, 49-93 (odd), 99, 105, 113, 117, 121 12. Solutions 39, 41, 43, 49 – 73 (odd), 79, 81, 89, 93, 95, 107 13. Rates of Reaction 33, 39, 45, 49-63 (odd), 67, 71, 75, 77, 79, 83, 85, 93, 99, 101, 105, 113, 121, 123, 125 14. Chemical Equilibrium 31, 35, 37, 41, 43, 49-61 (odd), 65, 69 – 77 (odd), 91, 101, 111 15. Acids and Bases 29 – 35 (odd), 41, 47, 53, 57, 67 – 99 (odd) 16. Acid-Base Equilibrium 35, 37, 41, 49, 53, 55, 59, 63, 67 – 75 (odd), 83, 85, 87, 91, 99, 105, 107, 113, 117, 121, 125 17. Solubility and Complex-Ion Equilibrium 27, 31, 33, 37, 41, 45, 51, 69, 75, 83, 95, 97 18. Thermodynamics and Equilibrium 33, 37 – 47 (odd), 55, 63 – 69 (odd), 73, 77, 83 – 91 (odd), 101 19. Electrochemistry 8/16/2011 43, 47, 55, 61 – 73 (odd), 79, 81, 85, 87, 93, 95, 107, 113, 115, 121, 139 20. Nuclear Chemistry To Be Announced by Instructor 7 of 9 Quizzes Exam 1 (2/9/12) Exam 2 (3/22/12) Exam 3 (4/26/12) Laboratory Class Participation Final Exam (TBA) 20% 15% 15% 15% 10% 5% 20% ABCDF 89 - 100 % 79 - 88 % 65 - 78 % 50 - 64 % < 50 % Total 100% Attendance: Attend lectures and labs regularly and be on time; frequent absences will performance. No make-up quizzes will be administered for any reason, so a missed quiz will be bring down a borderline Integrity: one of those dropped. However, if a student misses two or more regular quizzes, (s)he may earn replacement credit for one quiz score by completing a common, comprehensive replacement test during the last week of classes. A lab may only be made up during the same week; you must arrange this with another lab instructor. A missed lab will earn a score of 0, and more than three unexcused absences from the lab will result in a failing grade for the course. In case of serious illness, emergency, or conflict with an authorized University function, please contact your instructor as soon as the conflict is known. Students in this course are expected to adhere strictly to the ONU Student Code of Academic Conduct (see ONU Student Handbook). Week Date 1 3 4 8 12 14 15 16 Jan.10–12 2 Jan.17–19 Jan.24–26 Jan.31–Feb.2 5 Feb.7–9 6 Feb.14–16 7 Feb.21–23 Feb. 28 – March 1 9 March 13 – 15 10 March 20 – 22 11 no lab meeting this week 13 April 10 – 12 April 17 – 19 April 24 – 26 May1–3 March 27 – 29 Notes: Chemistry 1721/1821 General Chemistry 1 Laboratory Syllabus Spring Semester 2012 Experiment # Assignment No Lab Meeting Check In Gas Laws and Vapor Pressure Structures of Molecules and Solids (bring your model kits to lab) Freezing Point Depression Redox Reactions of Oxoanions Reaction Rates Rate Law for the Iodine Clock Reaction Triiodide Equilibrium Solubility of Calcium Iodate Acid-Base Strength of Salts Buffers and Potentiometric Titration Determination of pKa of an Acid-Base Indicator Thermodynamics and Equilibrium Electrochemical Cells Check Out 13 17 16 12 18 19 20 21 22 23 24 25 26 1. Come prepared each week for lab. Study the assigned lab procedure and relevant appendices. Obtain any needed table data (molar masses, etc.). Make procedural notes and data/observation tables in your notebook. All of this should be done before coming to the lab. The instructor may give a quiz at the start of the lab session. 2. Write down all primary data and observations directly in your lab notebook, not in your manual, report sheet, or extra papers. Also in the notebook, answer questions that are asked in the manual procedures and show calculations needed for the report sheet. Notebooks will be graded weekly (1 point per week). 3. A completed report sheet for the experiment should be returned to the TA at the end of the lab period unless otherwise notified. Your report grade will be based on the correctness of any calculations, including significant figures, the quality of your results, and the answers to any questions. 4. Safety goggles are to be worn in the laboratories at all times, unless the instructor specifically notes otherwise (e.g., during prelab lectures or quizzes). In particular, if any student is conducting an experiment, all students in the lab must have on goggles. 5. Lab quizzes will be given throughout the semester at the instructor’s discretion. A missed lab period, report, and quiz will be counted as “0”. If you must miss a lab for medical reasons or for a University- approved function, contact your instructor before the lab and arrange to make up the lab that week in another section. Labs cannot be made up in weeks following their assigned time. More than 3 unexcused 8/16/2011 absences from the lab will result in a failing grade for the semester. 6. Points earned in lab make up 10% of your Chem 1711 grade. Lab point distribution is as follows: Lab Notebooks Report Sheets Lab Quizzes 60 points Total 200 points 12 points 128 points Fall 2011 CHEMISTRY 2001 Course Syllabus CAPSTONE 1 Coordinator/Instructor: Dr. Jeffrey A. Gray j-gray@onu.edu 772-2337 MY 263 Class Meetings: Mondays at 3 PM in MT 248 Attendance: Students are expected to attend and participate in all regular class meetings. Each student must attend two research seminars by external speakers (departmental or ACS). Course Objectives: Students will become familiar with methods and objectives of modern chemical research, including current research opportunities in the department and external summer fellowship/internship positions. Students will learn to search the chemical literature for articles relevant to a particular topic. Each student will prepare a resume' suitable for applying to summer research positions in chemistry. Grading: Assignment Literature Search Literature Review Paper Resume' Quizzes and Homework Class Participation % of Total 20 20 10 30 20 Letter A B C D F %Range 85 - 100 70 - 85 60 - 69 50 - 59 < 50 Dr. Bates Dr. Celius Schedule: 11/7/11 11/14/11 11/21/11 11/28/11 12/5/11 faculty presentations faculty presentations summer experiences * revised resume due *quiz on faculty presentations Dr. Myers Dr. Broekemeier Dr. Spiese Dr. Dickson senior students Date Topic Assignment Presenter 8/22/11 Introduction to research Dr. Gray 8/29/11 Searching chemical literature Dr. Gray 9/5/11 LABOR DAY RECESS --------9/12/11 *quiz on literature searching 9/19/11 Preparing a resume Dr. Gray 9/26/11 CHEM 2971, 4971, and 48x1 summer opportunities literature search exercise due Dr. Gray 10/3/11 faculty presentations 8/16/2011 * Dr. Zimmerman Dr. Peterson 10/10/11 FALL RECESS --------10/17/11 faculty presentations resume due Dr. Bowers Dr. Anderson-Wile 10/24/11 faculty presentations Dr. Wile Dr. Perrine 10/31/11 summer opportunities exercise due faculty presentations All assignments should be submitted electronically (e.g. .pdf or .doc) Late work is penalized at the rate of 5% per day. No work will be accepted after Dec. 7, 2011. Integrity: Students in this course are expected to adhere strictly to the ONU Student Code of Academic Conduct (see ONU Student Handbook). Analytical Chemistry 1 CHEM 2311 Syllabus Fall 2011 Dr. Nicole Dickson Meyer 246A n-dickson.1@onu.edu (419) 772-2258 Dr. Chris Bowers Meyer 257 c-bowers@onu.edu (419) 772-2435 Textbook: Daniel C. Harris, Quantitative Chemical Analysis, 8th edition Lab notebook: A bound notebook is required for lab. Quad ruled is preferred. Lecture Schedule Exams: Cumulative exams are scheduled for September 27 and November 17. Exams will take place during the scheduled lab times. The location of the exam will be announced in class. Excused absences from exams include serious illness with a note from a doctor, emergency, or conflict with an authorized ONU function provided there is advanced notice. Make-up exams must be finished within three days of the scheduled exam. Exams will not be administered early. Quizzes and homework: Occasionally, homework may be assigned as deemed appropriate by the instructor. Students may work together on homework assignments provided that group members are listed on the work. References other than the required textbook must be cited. Quizzes may occasionally be administered and are the work of the individual student. Attendance: Attend all lectures and labs. Dates Topic Lecturer Aug 22 Intro Dr. Dickson/ Dr. Bowers Aug 24 - Sept 7 Error and Statistics Dr. Dickson Sept 12 - Sept 14 Review and Systematic Treatment of Equilibrium Dr. Bowers Sept 19 - Oct 3 Acids/ Bases, Buffers, Titrations Dr. Dickson Oct 5 - Oct 24 8/16/2011 Electrochemistry Dr. Bowers Oct 26 - Nov 9 Spectroscopy Dr. Dickson Nov. 14 - Dec 5 Mass Spectrometry, Separations, Chromatography Dr. Bowers Academic Conduct “The University has a duty to protect and strengthen its educational purpose by establishing standards of scholarship and conduct for students. The University expects its students to conduct themselves as mature members of the academic community, and it assumes that individually and collectively students will discourage acts of cheating. Academic offenses involving examinations, written work submitted for evaluation, improper knowledge of the contents of an examination, misrepresentation of facts relevant to academic matters, and all forms of improper or unethical conduct are subject to established adjudication procedures.” - ONU student handbook, p. 3, http://www.onu.edu/files/student_handbook.pdf Academic Conduct in Analytical Chemistry The following offenses will be treated as academic misconduct: Plagiarism of words or figures Falsification of data Unassigned collaboration (group effort on an individual assignment) Any of the offenses listed in the above academic conduct paragraph Grading: Homework and Quizzes Exam 1 Exam 2 Laboratory % of Final Grade 10 A 10 B 10 C 50 D 100 - 85% 85 – 70% 69 – 55% 55 – 40% <40% Lab Notebooks & Class Participation Final Exam (8 am 12/14 Meyer 206) 15 5 F Laboratory Schedule Lab reports: Lab reports are due by 6 pm one week after the lab was scheduled to be completed. For each lab exercise a full or short lab report will assigned. Details on these formats will be provided separately. Ten points will be deducted from the lab report grade for every day it is late. A total of 50 points will be deducted per week (i.e. weekends are free). Any student who does not complete all of the lab reports will fail the course. All lab reports must be handed in by Tuesday December 13, 2011. None will be accepted after this date. Lab Notebook: The lab notebook must be written in pen in legible handwriting. Each page should be dated and signed. Be as descriptive as possible. You may not remember everything you did in lab if you wait too long to write your lab report. Further details on maintaining a lab notebook will be provided. Date(s) Experiment Aug 23 Chapter 2 / Lab Orientation Aug 25 Standardization of a Base Aug 30 Identification of a Weak Acid Sept 1 Catch up and Statistics Lab Sept 6 Buffers 8/16/2011 Sept 8 Gravimetric Determination Sept 13 Gravimetric Determination Sept 15 Complexometric Titration Sept 20 Round Robin #1 Standard Preparation Sept 22 Instrumental Round Robin #1 Intro Sept 27 Exam Sept 29 – Oct 20 Instrumental Round Robin #1 Oct 25 Instrumental Round Robin #2 Intro Oct 27 – Nov 15 Instrumental Round Robin #2 Nov 17 Catch up Nov 22 Exam Nov 29 Chromatography Lecture Dec 1 Sample Prep & Separations Dec 6 Sample Prep Dec 8 Lab Cleanup/ Checkout Instructor: Office: Phone: Email: Web page: Office Hours: Text: Equip: Lecture: Requirements: CHEMISTRY 2511/2611 SYLLABUS Organic Chemistry 1 – Fall 2011 Dr. Amelia Anderson-Wile Meyer Hall 254 419-772-4207 a-anderson.4@onu.edu webct-new.onu.edu (Organic Chemistry 4 – Chem2511-04) Mon. 10:30am–12:00pm; Tue. 1:30–3:00pm; Wed. 9:00–11:00am, Open door, or by appt. “Organic Chemistry” 3rd ed. by J. G. Smith with Connect access code (ISBN: 9780077405717) Molecular Model kit 1-1:50 MWF in Mathile 248 Completion of CHEM 173 or 183 with a passing grade. Chem 2511/2611 is intended to be taken concurrently with Chem 2551/2651. If you withdraw from Chem 2551/2651, you must also withdraw from Chem 2511/2611. Point Breakdown: 3 exams, @ 140 points 420 6 quizzes, @ 40 points 200** Online Homework TOTAL 1000 POINTS ** The lowest quiz score will be dropped 130 Bonus 30 Final exam 250 8/16/2011 Quizzes & Exams: Grade Scale: >850 A 849–750 B 749–650 C 649–550 D There will be six 40-point quizzes given during the quarter. Each quiz will last 15-20 minutes and will cover the most recent material presented in lecture. The lowest quiz score of the semester will be dropped. There will be three 140-point exams given on Tuesday evenings from 7:00 – 7:50 pm. These exams will cover everything from the first day of class with an emphasis on the material covered since the previous exam. The final exam will be cumulative for the quarter with 100 out of the 250 points focused on the last 3 weeks of the semester. Online Homework (Connect) We will be using the McGraw-Hill Connect system for our online homework. It will be graded. We will multiply your percent correct times 130 to get the score for the course. 1. Go to the Connect web address (http://connect.mcgraw-hill.com/class/a_anderson-wile_fall_2011_anderson-wile) 2. Click on Register Now. 3. Enter your email address (this will become your Connect username). As a best practice, you may want to register with your school/institution email address. TIP: If you already have a McGraw-Hill account, you will be asked for your password and will not be required to create a new account. 4. Enter a registration code or choose Buy Online to purchase access online. 5. Follow the on-screen directions. 6. When registration is complete, click on Go to Connect Now. 7. Open section homepage and follow the directions for installing the ChemDraw Plug-In. Only 32-bit browsers are supported. 8. For issues with Connect, see the documents “Installing the ChemDraw Plug-In for Windows”, “Installing the ChemDraw Plug-In for Mac” or “Connect Student Quick Tips” on our course WebCt page, visit the McGraw Hill website (http://mpss.mhhe.com/student_connect_resources.php) or call McGraw Hill support (1-800-3315094) Tentative Class Schedule:* Date 08/22 M 08/24 W 08/25 F 08/29 M 08/31 W 09/02 F 09/05 M 09/07 W 09/09 F 09/12 M 09/14 W 09/16 F 09/19 M 09/21 W 09/23 F T opic Periodic Table, Bonding, Lewis Structures, Formal Charge, Isomers Resonance, Molecular Shape (VSEPR), Drawing molecules, Bonding and Hybridization Bonding and Hybridization (cont.), Bond Lengths and Strengths, Electronegativity, Bond Polarity, Dipoles, Polarity of Molecules, Intro to Acids and Bases No Class-Material is covered in the Online Homework No Class-Material is covered in the Online Homework Lewis and B-L Acids and Bases, Acid Strength, pKa No class—Labor Day Quiz 1. Predicting Acid/base Reactions Common Acids and Bases, Functional Groups Intermolecular Forces, Physical Properties Alkanes Nomenclature, Naming special groups, Reactions of alkanes IUPAC nomenclature, conformations, Newman Projections of ethane Quiz 2. Newman Projections of butane, Cycloalkanes, Cyclohexane Conformers Substituted Cyclohexanes Stereoisomers, Chirality, Stereogenic Centers Reading 1.1 – 1.4 1.5 – 1.9 1.8 – 1.10, 1.11 – 2.1, 2.1 – 2.3, 2.8 2.4 – 2.7, 3.1 2.8 – 3.2 3.3 – 3.8 4.1 – 4.3, 4.14 4.4 – 4.10 4.11 – 4.12 4.12 – 4.13 5.1 – 5.4 5.5 5.7 – 5.11 5.12 – 5.13 6.1 – 6.9 6.10 – 7.4 7.5 – 7.12 7.13 – 7.16, 7.19 7.16 – 7.18 8.1 – 8.5 8.6 – 8.10 8.11 9.1 – 9.5 9.6 – 9.16 9.10-9.13 9.14-9.17 10.1-10.9 10.10–10.14 10.15-10.17 10.18-11.3 11.4-11.8 11.9-11.12 10.2; 13; 16.15 13.5-13.8 14.1;14.11 14 14 14 13.1-13.4 13.1-13.4 09/26 M Assigning Absolute Configuration 09/27 T* 09/28 W Exam 1 Diastereomers, Meso Compounds, Isomer flow chart 09/30 F Physical Properties of Stereoisomers, Chemical Properties of Enantiomers 10/03 M 10/05 W 10/07 F 8/16/2011 10/10 M 10/11 T 10/12 W 10/14 F 10/17 M 10/19 W 10/21 F 10/24 M 10/25 T* 10/26 W 10/28 F 10/31 M 11/02 W 11/04 F 11/07 M 11/09 W 11/11 F 11/14 M 11/16 W 11/18 F 11/21 M 11/22 T* 11/23 W 11/25 F 11/28 M 11/30 W 12/02 F 12/05 M 12/07 W 12/09 F Writing Org. Reactions, Types or Reactions, Making & Breaking Bonds, React. Intermediates, Arrows, BDE, Thermodynamics, Enthalpy, Entropy, Energy Diagrams Quiz 3. Kinetics, Catalysts, Alkyl halides (Nomenclature & Physical Properties) No class – President Inauguration No class—Fall Recess No class—Fall Recess Nucleophilic Substitution (Intro SN1 & SN2), SN2 mechanism, Leaving groups Nucleophiles, Solvents, Synthesis of several functional groups (See table 7.8) Quiz 4. SN1 Mechanism, Carbocation Stability, Hyperconjugation, SN1 vs SN2 Alkenes, E2 Stereochemistry of E2, Zaitsev’s Rule, Stability of Alkenes, E1 E1 vs. E2 vs. Substitution vs. Elimination Exam 2 Alcohols & Ethers Nomenclature, Physical Properties, Preparation, Dehydration Carbocation Rearrangements, Tosylates, Conversion to Alkyl Halides, Cleavage of Ethers, Rxns of Epoxides Dehydrations; Conversion to Alkyl Halides, Tosylates Reaction of Ethers with Acid; Reactions of Epoxides Quiz 5. Alkene Physical Properties; Nomenclature; Lipids; Preparation; Halogenation Markovnikov’s Rule; Stereochemistry of Addition, Hydration Halohydrin Formation; Hydroboration-oxidation; Synthesis; Alkyne Nomenclature; Preparation Acetylide Anions; Addition of HX Quiz 6. Addition of Halogens and/or H2O; Hydroboration; Acetylide Anions; Retrosynthesis Introduction Spectroscopy; Using Molecular Formula (MF); UV Spectra and Conjugation Infrared Spectroscopy Exam 3 No class—Thanksgiving Recess No class—Thanksgiving Recess Intro to NMR Spectroscopy; 13C NMR Chemical Shift NMR Spectroscopy, Theory, Terminology, Chemical Shift 1H NMR: Chemical Shift, Integration, 1st Order Splitting (N+1 rule) 1H NMR: Splitting (cont.) and examples Bonus Problem set due. Mass Spectroscopy and Determining MF MS Fragmentation; Solving Structure Problems 12/12-16 *Tuesday evening time blocks (7:00-7:50 PM) are designated for exams and problem/answer sessions. The exams are labeled, however, the problem/answer sessions will be scheduled on an as needed basis determined by your instructor. Final Exam TBD Connect homework Assignment Due Dates and Learn Smart Study Module Availability: Graded homework assignments will be available on Connect one week prior to the due date. Assignments must be completed by 11:59 pm on the date listed. The Learn Smart (LS) study module for chapter 1 will be a graded assignment. All other Learn Smart study modules will not be graded, but will be available as additional online practice problems. Learning Goals: Assuming you fulfill the expectations listed below, you should be able to understand the following concepts by the end of the semester: 1. Bonding – Particular attention will be paid to elements (H, C, N, O, S, Cl, Br) commonly used in organic chemistry. Identification of both reasonable and unreasonable bonding modes for these elements will be crucial in determining the products of different organic reactions. 2. Acids and Bases – Students will be expected to identify the acid or base properties of a variety of molecules. These concepts will be utilized continually throughout Organic I and II! 3. Functional Groups – Functional groups exhibit varying properties that influence their reactivity in organic reactions. Students should be able to identify all organic functional groups. We will begin our study of the specific characteritics of the following functional groups this semester: alkanes, alkenes, alkynes, alcohols, ethers, epoxides, alkyl halides. 4. Stereochemistry – Students will be expected to identify and visualize the 3D structure of organic molecules. The spatial arrangement of molecules can be helpful for the determination of reaction mechanisms. 5. Reaction Mechanisms – The student’s knowledge of bonding, acids, bases, functional groups and stereochemistry will be utilized to determine reaction mechanisms and products. To predict the correct products of organic reactions, the student must have a clear understanding of goals 1 – 4. 6. Spectroscopy – Chemists utilize IR, NMR and MS to determine the structure of organic molecules. 8/16/2011 Students will be expected to analyze spectra and determine the products of organic reactions using these techniques. Course Expectations: To succeed in this course, you must commit to the following: 1. To attend class, be attentive and participate in class. While you are in lecture, I expect you to be a fully engaged participant, rather than a passive observer. This means that no texting, emailing, or chatting (including Facebook, instant messaging, etc.) during the class session! This is exceptionally distracting for you (even if you don’t realize it), not to mention your fellow students, and me. If your phone rings, or you are engaged in a “digital distraction” during class, I reserve the right to move the offending technology from your immediate vicinity until the lecture has concluded. Assignments (graded) Due Date Ch. 1 LS Ch. 1 Ch. 2 Ch. 3 Ch. 4 Ch. 5 Ch. 6 Ch. 7 Ch. 8 Ch. 9 Ch. 10 Ch. 11 Ch. 13 Ch. 14 8/29 Mon. 8/31 Wed. 9/11 Sun. 9/15 Thur. 9/25 Sun. 10/03 Mon. 10/11 Tue. 10/20 Thur. 10/24 Mon. 11/06 Sun. 11/14 Mon. 11/20 Sun. 11/29 Tue. 12/11 Sun. Learn Smart Study Modules (ungraded) A vailable Ch. 2 – 4 Ch. 5 Ch. 6 – 8 Ch. 9 – 11 Ch. 13 – 14 8/22 – 9/27 9/20 – 10/25 9/28 – 10/25 10/26 – 11/22 11/16 – 12/16 2. To read the assigned materials. Your textbook is your primary learning resource. Read the assigned chapters prior to attending class. In class, I will stress the most important points and clarify difficult material. Lectures will not necessarily cover all the required material, and all the material covered in class will not necessarily be covered in the text. Thus, it is very important that you read the text and attend lecture. It is strongly recommended that you read the assigned chapters prior to attending the lecture on the topic. 3. To work problems on a regular basis. You cannot learn organic chemistry without doing practice problems. Make certain that you understand the problem instead of just being able to reproduce the solution. While working problems, it is strongly suggested that you refer back to the text and reread sections of the previous chapters to find the information you need to answer the question. You should only use the solutions manual to check problems, not to learn how to do the problems. Some students find it helpful to write up the problem set as if they are going to turn it in to the instructor. Do a couple problems each day. Although memorization of some key subject matter is required, it is necessary to learn concepts and apply them to the task at hand. Do not confuse having memorized class material (or solutions to a particular problem) as having learned the concepts. Understanding implies application of the information that you have acquired to solve new problems. 4. To ask for help when you need it. Organic chemistry is a cumulative subject: understanding the new material requires that you have mastered earlier material. Please visit my office hours or schedule a time to meet with me and I will answer any questions (big or small) you might have! Incompletes: Incompletes will be given only when the work of the course is substantially completed and when the student's work is of passing quality. Academic Misconduct: “Ohio Northern University students have an obligation to maintain the highest standards of ethical conduct.” Any student deviating from these standards will be penalized to the fullest extent possible. See page 44 of the 2009–11 ONU catalog and Appendix F of the Student Handbook. Students with Disabilities: ONU does not discriminate against qualified individuals with disabilities. Accordingly, the school will provide reasonable academic accommodations when the student provides sufficient documentation describing his or her disability and the accommodation(s) requested in accordance with school procedures. If you are eligible to receive an accommodation and would like to make a formal request for this course, please discuss it with me and allow a minimum of two weeks advance notice. You will also need to contact Melissa Verb, Assistant to the Dean (Getty College of Arts & Sciences) by phone (x2534) or email (m-verb@onu.edu) with appropriate documentation of your disability. 8/16/2011 Makeups: In the event that you feel that you will be unable to attend a scheduled exam/quiz, you must contact me prior to (or as soon as safely feasibly) to discuss your situation (by phone and email). If an excused absence is granted by the instructor, the instructor reserves the right to 1) provide a makeup exam that contains questions covering material up to the day of the makeup exam, 2) administer a cumulative makeup exam at the end of term, 3) prorate the final, or 4) use other means of evaluation that are agreeable between the instructor and the student. The instructor reserves the right to choose the method of makeup, which will generally be in the form of option #3. Unexcused absences including (but not limited to): sleeping through the exam, not informing the instructor in a timely fashion, and vacation travel will result in the score of zero. Makeup exams will not be given to students before the class has taken the exam. 9/30/2011 CHEMISTRY 2521/2621 SYLLABUS, Spring 2012 Organic Chemistry 2 Dr. Brian Myers Meyer Hall 256 419-772-2350 b-myers@onu.edu http://www2.onu.edu/~b-myers/organic/ and webct.onu.edu Mon. 11–12, 2–3; Tues. 10:30–11:30; Wed. 2–3; Thurs. 1:30–2, Open door, or by appt. “Organic Chemistry” 3rd edition by J. G. Smith (ISBN: 9780077354725) **(the Study Guide is recommended) Molecular Model kit, a code to access the Connect homework system 1–1:50 MWF in Mathile 247 You must have completed CHEM 2511 or 25611 with a passing grade to enroll in this course. There will be six 40-point quizzes given during the semester. Each quiz will last 15 minutes and will cover the most recent material presented in lecture (**The lowest quiz score will be dropped). There will be three 140-point, Tuesday evening exams (7:00-7:50 PM) and a 250-point final exam. The exams will cover everything from the first day of class with an emphasis on the material covered since the previous exam. The final exam will be cumulative for the quarter with about 100/250 points covering material from the last 3 weeks of the term. Online Homework (Connect System) We will be using the McGraw-Hill Connect system for our online homework. It will be graded. We will multiply your percent correct times 130 to get the score for the course. 1. Go to the Connect Web Address (http://connect.mcgraw-hill.com/class/b_myers_fall2011organic) 2. Click on Register Now. 3. Enter your email address (this will become your Connect username). As a best practice, you may want to register with your school/institution email address. TIP: If you already have a McGraw-Hill account, you will be asked for your password and will not be required to create a new account. 4. Enter a registration code or choose Buy Online to purchase access online. 5. Follow the on-screen directions. 6. When registration is complete, click on Go to Connect Now. 7. Open section homepage and follow the directions for installing the ChemDraw Plug-In. Only 32-bit browsers are supported. 8. For issues with Connect, see the documents “Installing the ChemDraw Plug-in” or “Connect Student Quick Tips” on my website address (see above), visit the McGraw Hill website (http://mpss.mhhe.com/student_connect_resources.php) or call McGraw Hill support (1-800-331-5094). 9/30/2011 Tentative Class Schedule, Organic Chemistry 2: Week Topic Week 1 Chapter 12: Oxidation and Reduction 8/16/2011 Week 2 Chapter 15: Radical Reactions Week 3 Chapter 16: Conjugation, Resonance and Dienes Week 4 Chapter 17: Benzene and Aromatic Compounds Week 5 Chapter 18: Electrophilic Aromatic Substitution Week 6 Chapter 19 Carboxylic Acids and the Acidity of the O—H Bond Week 7 Chapter 20: Introduction to Carbonyl Chemistry: Organometallic Reagents Week 8 Chapter 21: Aldehydes and Ketones–Nucleophilic Addition Week 9 Chapter 22: Carboxylic Acids and Their Derivatives 2 9/30/2011 Week 10 Chapter 22: Carboxylic Acids and Their Derivatives Week 11 Chapter 23: Substitution Reactions of Carbonyl Compounds at the carbon Week 12 Chapter 24: Carbonyl Condensation Reactions Week 13 Chapter 25: Amines Week 14 Chapter 27: Carbohydrates Week 15 Special topics in Organic Chemistry FINAL EXAM 4–6 PM (ROOM TBA) Withdraws: In the event that you need to withdraw from CHEM 2561 (Organic 2 laboratory) or CHEM 2661 (Organic 2 laboratory for majors), you must also withdraw from CHEM 2521 or CHEM 2621, respectively, since you will not receive credit for this co-requisite course. Incompletes: Incompletes will be given only when the work of the course is substantially completed and when the student's work is of passing quality. Academic Misconduct: The ONU Catalog and Appendix F of the Student Handbook states “Ohio Northern University students have an obligation to maintain the highest standards of ethical conduct.” To this end, any student deviating from these standards in this course will be penalized to the fullest extent possible. 3 9/30/2011 Makeups: In the event that you feel that you will be unable to attend a scheduled exam/quiz, you must contact me prior to (or as soon as safely feasibly) to discuss your situation (by phone and email). If an excused absence is granted by the instructor, the instructor reserves the right to 1) provide a makeup exam that contains questions covering material up to the day of the makeup exam, 2) administer a cumulative makeup exam at the end of term, 3) prorate the final, or 4) use other means of evaluation that are agreeable between the instructor and the student. The instructor reserves the right to choose the method of makeup, which will generally be in the form of option #3. Unexcused absences including (but not limited to): sleeping through the exam, not informing the instructor in a timely fashion, and vacation travel will result in the score of zero. Departmental policy dictates that makeup exams will not be given to students before the class has taken the exam. Suggestions: Your textbook is your primary learning resource. Read the assigned chapters prior to attending class. In 8/16/2011 class, I will stress the most important points and clarify difficult material. Lectures will not necessarily cover all the required material, and all the material covered in class will not necessarily be covered in the text. Thus, it is very important that you read the text and attend lecture. Organic chemistry is a cumulative subject: understanding the new material requires that you have mastered earlier material. Therefore, it is extremely important that you keep up with the reading. It is strongly recommended that you read the assigned chapters prior to attending the lecture on the topic. Work the assigned problems! You cannot learn organic chemistry without doing practice problems. Make certain that you understand the problem instead of just being able to reproduce the solution. While working problems, it is strongly suggested that you refer back to the text and reread sections of the previous chapters to find the information you need to answer the question. You should only use the solutions manual to check problems, not to learn how to do the problems. Some students find it helpful to write up the problem set as if they are going to turn it in to the instructor. Do a couple problems each day. Although memorization of some key subject matter is required, it is necessary to learn concepts and apply them to the task at hand. Do not confuse having memorized class material (or solutions to a particular problem) as having learned the concepts. Understanding implies application of the information that you have acquired to solve new problems. Studying in small groups (2-3 people) can be very beneficial and is strongly recommended, but do not do the majority of your studying for this course in groups. The most effective way to study with a group is to discuss the issues with which you are having the most difficulty. If you are having difficulty with this course, come to see me ASAP. If you do not know where to start asking questions, the question that needs answered is “When can I get in to see my instructor?” Also, see the link to Golden Rules to learning Org. Chem.: http://www2.onu.edu/~b-myers/organic/ Using cell phones in class is disruptive to the class, please do not use them during lecture. You are responsible for every problem in the text. 4 CHEM 2651 Syllabus Laboratory for Organic Chemistry 1 FALL 2011 Time/Location: Tuesday in Meyer 217 Instructors: Drs. Anderson-Wile, Celius, Manpadi, Myers, Zimmerman and Ms. Grine Objectives: The lab experiments in this course are designed to illustrate the practical implementation of the theories and concepts discussed in the Chem 2511 lecture course. The laboratory experiments and exercises will enhance and deepen your understanding of the lecture materials. Required Texts: Organic Chemistry Laboratory Experiments and Exercises (the Lab Manual). 2011 Edition Smith, J.G. Organic Chemistry. 3rd ed. (TEXT), McGraw Hill Required equipment: Safety goggles, a carbonless copy notebook, and appropriate laboratory attire as specified on page 2 of the Lab Manual under “Lab Attire & Protective Clothing.” Requirements: Completion of CHEM 173 or 183 with a passing grade. Chem 2551 is intended to be taken concurrently with Chem 2511. If you withdraw from Chem 2511 you must also withdraw from Chem 2551. In the event that you must withdraw from Chemistry 2551, you must arrange a time with your instructor to 8/16/2011 check-out of your drawer. If you do not checkout of your drawer, a hold will be placed on your university account. WebCT: Laboratory assignments, and supplemental materials will be available online through the WebCT site (http://webct-new.onu.edu). Your logon ID and password are the same as your Luminis ID. If you have problems accessing the course or WebCT, please contact the IT helpdesk (x1111). Preparedness: The student must complete the notebook table, prelab exercise, and assigned reading prior to the lab period. Lab notebook: Please refer to the Lab Manual pages 8–10. Missing Lab/Makeups: In the unlikely event that you are unable to attend lab, you need to let your lab instructor know immediately by email and/or phone. For an excused absence you will need to complete the experiment during a different time. If this is not possible, your laboratory score will be prorated based on your performance during the semester. For an unexcused absence, you will receive zero points for all the graded activities associated with that laboratory period. Three unexcused absences will result in immediate failure of the course. Safety: Please be aware that the lab experiments you will complete require the use of toxic substances. Thus, prudent attention to safety practices should be followed at all times. Please make your instructor aware of any medical conditions that might affect your ability to safely complete these experiments. 8/16/2011 Grading: The overall grade in the course will be determined by the following point breakdown Possible Points Quizzes (3 x 30 pts each) 90 Worksheets (7 x 20 pts each) 140 Online prelab assignments (5 x 5 pts each) 25 Paper prelab assignments (2 x 5 pts each) 10 Lab notes (6 x 6 pts each) 36 Laboratory Exam (week 14) 50 Total 351 Grading Scale A B C D Worse 85.0 – 100% 75.0 – 84.9% 65.0 – 74.9% 55.0 – 64.9% 0 – 54.9% Academic Misconduct: While individually carrying out the experiments and techniques is essential, students are encouraged to share their results and observations in the lab. However, each student must complete lab reports as well as any other work submitted for a grade without the help of others. Plagiarism and dishonesty will be severely penalized. “Ohio Northern University students have an obligation to maintain the highest standards of ethical conduct.” Any student deviating from these standards will be penalized to the fullest extent possible. See the 2011-12 ONU catalog and the student handbook. 67 CHEMISTRY 2551 LAB SCHEDULE, Tuesdays MY217, FALL 2011-12 Date Lab Experiment Title August 23 Safety lecture, Check-in August 30 No Lab September 6 September 13 September 20 September 27 October 4 October 11 October 18 Recrystallization Turn in notebook pages Measurement of Acid Strength A WebCT prelab is due Turn in individual worksheet next week Infrared Spectroscopy, Quiz 1 A worksheet (handed out in lab) will be due Melting Point A prelab is due Turn in notebook pages Simple and Fractional Distillation A WebCT prelab is due Turn in the worksheet next week No Lab Extraction I A paper prelab is due Extraction II October 25 Quiz 2 Turn in the group worksheet TLC November 1 Turn in notebook pages Nucleophilic Substitution Reactions November 8 A WebCT prelab is due Turn in notebook pages Dehydration of 2-Methylcyclohexanol, Check-out November 15 A WebCT prelab is due Turn in notebook pages, Quiz 3 A 2-step reaction on trans-stilbene A WebCT prelab is due November 22 Turn in Notebook Pages 13C & DEPT NMR Spectroscopy November 29 Turn in individual worksheet Lab Exam Proton NMR: Coupling Constants (Jab) December 6 Turn in individual worksheet TEXT = Smith, 3rd Edition Required Reading (Lab Manual/Text) p. 15–21 p. 35–41 TEXT: 54–71 p. 42–44 TEXT: 476–485 & see index p. 58–64 TEXT: 92–93 p. 27–34 TEXT: 90-92, 128-129 p. 45–53 TEXT: 707–709, 966– 968, Prob. 25.59 ibid p. 61–64 TEXT: 44–45 p. 73–77 TEXT: 234–267 p. 77 TEXT: 325–330 80–82 TEXT: 379–382 pp. 88–91 TEXT: 495–501 pp. 92–98 TEXT: 502–527 68 Lab for Organic Chemistry III Chemistry 266 W&F 2:00–5:00PMinMY206and217 Professor: Dr. Tevye C. Celius Office: Meyer Hall 268 Lab: Meyer Hall 249 Phone: 772-3020 e-mail: t-celius@onu.edu Office hours: Whenever you need to talk to me! (See below for more details) Office Hours I am available most of the time during the day when I am not teaching a lab or lecturing. Come by and see me in my office or in my research lab. I also have scheduled office hours from 11:00 – 12:00 on Mondays, Tuesdays, Wednesdays, and Fridays, and from 12:00 – 1:00 on Tuesdays. You may also schedule a specific time to meet with me if you prefer. I also encourage you to make use of e-mail as a way to contact me and to ask simpler questions. I will make my best effort to respond to e-mail quickly. Prerequisites You must have completed CHEM 252 or CHEM 262 with a passing grade. Required Texts and Equipment Organic Chemistr, Third Edition by Janice Gorzynski Smith. ISBN: 978-0-07- 735472-5 Spectrometric Identification of Organic Compounds,Sseventh Edition by Silverstien, Webster, and Kiemle. ISBN:978-471-39362-7 Organic Chemistry Laboratory Experiments and Exercises, 2010 Edition by Celius, Grine, Myers, Peterson, and Zimmerman Spartan Model Kit purchased on line Goggles Carbonless copy notebook Safety Please be aware that the lab experiments you will complete require the use of toxic substances. Thus, prudent attention to safety practices should be followed at all times. Please make your instructor aware of any medical conditions that might affect your ability to safely complete these experiments. Academic Misconduct While individually carrying out the experiments and techniques is essential, students are encouraged to share their results and observations in the lab; however, each student must complete lab reports as well as any other work submitted for grade without help of others. Plagiarism and dishonesty will be severely penalized. “Ohio Northern University students have an obligation to maintain the highest standards of ethical conduct.” Any student deviating from these standards will be penalized to the fullest extent possible. See the 2009–11 ONU catalog and the student handbook. 263/266 Point Breakdown Point Breakdown: 3 exams, @ 140 points 420 2 quizzes, @ 40 points 80 Sappling learning 50 Grade Scale: >85% A 75–84% B 65–74% C 55–64% D Final exam 250 Subtotal: 800 70% ( x 0.875) 700 Laboratory 300 TOTAL 1000 POINTS 69 A grade is not actually assigned to Chemistry 266; however, the lab accounts for 30% of the grade for Chemistry 263 (5 Credit hours; 3 hours of lecture, 6 hours of lab per week). Whereas, Chemistry 256 accounts for 20% of the 253 grade (4 Course credit hours, 3 hours of lab per week). Thus, your course score = [prorated Lecture (max, 700 pts) = 0.875 x (raw lecture)] + [lab (max, 300 pts)]. Chemistry 266 Laboratory Score Breakdown Unknown identifications (4 x 30) 120 Synthesis Labs: Condensation 40 Polymer 20 Y east 20 Grignard 10 Spartan Model 30 Exercises (6 x 10) 60 ChemDraw, NMR, Solubility, Peer Review, 13C NMR, 2D NMR __ Total: 300 Late items will constitute in 2% reduction in score Lab Policy In this course, students are given the opportunity to work (at times) outside of the normal laboratory time. Thus, students are able to work at a pace that suits them. Anytime that a student would like to work outside of scheduled lab hours, the instructor should be consulted. At no time, should the students taking this course disrupt the normal activities of another course. Any instance of unauthorized experiments will be referred to the university governance system. Finally, anyone not having fun in this course will be referred to the Department Office to receive the appropriate corrective behavior. Tentative Class Schedule Date 3/9 W 3/11 F 3/16 W 3/18 F 3/23 W 3/25 F 3/30 W 4/1 F 4/6 W Topic Check-in, Searching the literature, introduction to ChemDraw, Spartan Model Solubility Introduction to using the NMR Grignard Experiment Polymer Lab Polymer Lab UV Spectra IR Yeast Lab/Rotations Assignments Reading Due 4/8 F MS fragmentation Scifinder/Chemdraw Chemical Orders Spartan model 1 NMR and sol Grignard lab Polymer lab Spartan model 2 13C NMR Yeast Lab Unknown 1 Chapter 7 Handout Chapter 2 Chapter 1 Chapter 4 Chapter 3 Chapter 3 4/13 W 4/15 F 4/20 W 4/22 F 4/27 W 4/29 F 5/4 W 5/6 F 5/11 W 5/13 F 13C NMR NMR NMR Easter (NO LAB) NMR NMR NMR Condensation for Peer review Chapter 5 Chapter 3 Chapter 5 NMR Check-out 70 Peer Reviews Spartan model 3 2D-NMR Unknown 2, 3, and 4 Condensation Final paper Chapter 6 Physical Chemistry 1: Thermodynamics and Quantum Mechanics Instructor: Office: Phone: Lectures: Laboratory: Texts: Dr. Trilisa M. Perrine (t-perrine@onu.edu) 267 Meyer (419) 772-2340 Meyer 205 -- MWF 10:00-10:50 am Meyer 205/220 -- T 12:00-2:45 pm Lecture -- Physical Chemistry by Silbey, Alberty and Bawendi, 4th edition Lab -- Experiments in Physical Chemistry, by Shoemaker et al., 8th edition Office Hours: M, W R R 1:00 pm to 2:00 pm 10:00 am to 11:00 am 1:00 pm to 3:00 pm Office hours will also be posted next to the door of my office. Feel free to stop by any time, however, to ask questions etc. Occasionally, I may be in my office, but not available to help, but those times will be very rare. If you want to make sure I’ll be around when you come in for assistance though, feel free to email me and we’ll make an appointment. Grading: Your grade will be determined by the following components: Laboratory Midterm Exam 1 Midterm Exam 2 Problem Sets, Quizzes, and Presentations Final Exam Total 20% 20% 20% 20% 20% 100% Attendance, participation, effort and improvement over the term will also be taken into account when determining final grades. These will have the most influence when a student’s scores are near a division of two grades. Grading Scale: The following grading scale shows the guaranteed percentages which will be associated with certain letter grades. The percentages needed to obtain a certain grade may become lower in the final determination of grades, but will not become higher. A B 90% - 100% 80% - 89% C D 70% - 79% 60% - 69% In other words, a student who maintains an average of 90% or higher WILL receive an A in the class. A student who maintains an 89% average in the course is guaranteed a B in the class, but may obtain an A depending on overall class performance, attendance and participation, etc. 71 Reading: Students should read the entirety of each chapter whether we cover every topic in the chapter in lecture or not. Some students will benefit from reading the chapters before we cover them in lecture; others will prefer to read the book directly after we discuss a certain topic. Either strategy (or both) is acceptable. Choose whichever assists you in the learning process most, but students are responsible for all of the material in the covered chapters and not only the material covered in lecture. Presentations: In your laboratory groups, you will be designing and giving an in class presentation during a laboratory session (see the schedule below). The topics and more information concerning the content and guidelines will be given to you during the first week of lab. This presentation will be equivalent to twice that of a quiz or problem set (i.e. when figuring the “problem set, quizzes and presentations” portion of your grade, the presentation grade will be counted twice in that average). Exams: There will be three exams in this course: two midterm exams and a final exam at the end of the semester. They are scheduled for: October 4th and November 8th during the lab period and December 16th from 8-10:30am. The first midterm will cover Chapters 1-3 and likely part of Chapter 4. The second midterm exam will be cumulative over Chapters 1-6 of the textbook (the thermodynamics section of the course), but will focus more on the second half of that material than the first. The final exam will be primarily over the quantum mechanics portion of the course (Chapters 9-11). Problem Sets and Quizzes: Periodically, you will be given a list of problems from the chapter or chapters that we have covered to work through. These will serve to help solidify the concepts we’ve discussed in lecture. On alternate weeks some of the problems will be collected at the beginning of lecture on the day they are due and graded. The problems which will be collected will be noted on the problem sets that you are given. On other weeks (see the schedule below) quizzes will be given during the Friday lecture period. Combined, the quizzes, collected problem sets, and the presentation will be worth 20% of your total grade in the course. The number of quizzes and problems sets may change slightly from the below schedule if needed. Laboratory Preparation: You will be expected to be prepared for your laboratory experiment each week. This year the time in lab will be fairly constrained, given that many of you are also in the analytical lab, so preparation will be critically important. This preparation entails having read the worksheet and pertinent information from the lab textbook before coming to class. You also should have prepared your lab notebook for the collection of data and summarized the work you will be performing. Copies of your notebook pages will be collected and will constitute a small percentage of your laboratory grade. The pages should include: a statement of purpose, table(s) listing each quantity to be measured and the device(s) which will be used, equations showing how each derived quantity will be calculated, and a brief summary of the procedure (preferably in bullet points). The lab will also be open during my afternoon office hours on Thursdays for student to complete any trials necessary. Laboratory Reports: 72 Extensions: Schedule: Most lab reports will be due one week after the laboratory experiment is performed (see the schedule for exceptions) at the beginning of the lab period. Some reports will be in the form of a short report sheet, others will be full written reports. For your first full written report you will need to turn in a first draft, which will be returned to you with comments and suggestions for improvement. You will then be given a chance to revise the report and submit a final draft a week after the midterm exam. More information about how to write and what is expected in a full written laboratory report will be given during the first lab session. Late reports will be penalized 5% per day (unless permission for an extension is given at least 24 hours before the due date). Though you will be working in groups on the experiment, each student must submit an original report (either a report sheet or a full written report). While you are encouraged to work together on thinking through the concepts, equations and calculations, each student must write his or her report independently. Overly collaborative reports will be penalized or rejected altogether. On extremely rare occasions an extension may be granted on a problem set or laboratory report. Permission for an extension must be received from Dr. Perrine at least 24 hours before an assignment is due, in order for the assignment not to be penalized for being late. NO PROBLEM SETS OR LAB REPORTS WILL BE ACCEPTED AFTER THE FIRST DAY OF FINALS WEEK, DECEMBER 12, 2011 This schedule is approximate, and we’ll adjust as we go along if necessary: 73 Lecture Schedule Week of Laboratory Schedule Mon Wed Fri Group 1 Group 2 Group 3 1 22-Aug Intro / Ch 1 Ch1 Ch1 Lecture \ Lab Intro \ Writing Guidelines (In Class Worksheet) 2 29-Aug Ch1 Ch2 Ch2 / PS1 Lecture \ Error propagation (Assignment) Due Dates (Usually Tues) 6-Sep 3 5-Sep Labor Day Ch2 Ch2 A (Full Report First Draft) 4 12-Sep Ch2 Ch2 Quiz 1 C (Mini Report) A (Full Report First Draft) B (Report Form) 20-Sep 5 19-Sep Ch3 Ch3 Ch3 B (Report Form) C (Mini Report) A (Full Report First Draft) 27-Sep 6 26-Sep Ch3 / Ch4 Ch4 Ch4 / PS2 Pre-lab Lectures 7 3-Oct Ch4 Ch4 Ch4 / Ch5 Midterm 1 4-Oct Break 12-Oct (A - Final Draft) B (Report Form) C (Mini Report) 13-Sep None 8 10-Oct Break Ch5 Ch5 9 17-Oct Ch5 Ch5 / Ch6 Ch6 / PS3 D (Full Report) E (Full Report) F (Mini Report) 25-Oct 10 24-Oct Ch6 Ch6 Quiz 2 F (Mini Report) D (Full Report) E (Full Report) 1-Nov 11 31-Oct Ch6 Ch6 Ch9 E (Full Report) F (Mini Report) D (Full Report) 15-Nov 12 7-Nov Ch9 Ch9 Ch9 Midterm 2 8-Nov 13 14-Nov Ch9 Ch9 Ch10 Pre-lab Lectures & Presentations (Written Description) 22-Nov 14 21-Nov Ch10 / PS4 G (Report Form) H (Full Report) I (Mini Report) 29-Nov 15 28-Nov Ch10 Ch11 Ch11 I (Mini Report) G (Report Form) H (Full Report) 6-Dec 16 5-Dec Ch11 Ch11 Ch12 / PS5 H (Full Report) I (Mini Report) G (Report Form) 12-Dec Fin 12-Dec Final Exam Friday 8-10:30AM Thanksgiving Laboratory: In lab, you will be divided into three groups. Some weeks all three groups will be performing the same exercise. In other weeks we will rotate the experiments through the groups. The laboratory experiments listed in the above schedule as letters are given by the following designations: 74 A – Heats of Combustion B – Electronics C – Spreadsheets lab D – Heats of Ionic Reactions E – Partial Molar Volumes F – Computational Chemistry G – Electrochemistry H – Pressure-Volume I – Mystery Lab CHEM 3421 SPRING 2012 Physical Chemistry 2 Molecular Spectroscopy, Statistical Thermodynamics, and Kinetics Instructor: TA: Meetings: Prerequisite: Texts: Lecture: Lab: Lecture Outline: Lab Schedule: Assignments: Grading: Dr. Jeffrey A. Gray www2.onu.edu/~j-gray/ Mitchell Thayer Lecture: MWF Lab: T Help: R passing grade in CHEM 3411 x2337 Meyer 263 j-gray@onu.edu I. II. III. II. III. IV. I. II. III. IV. Structure and Symmetry Molecular Spectroscopy Statistical Thermodynamics Gas Kinetic Theory Kinetics and Dynamics Molecular Properties Week(s) 1 – 2 3 – 6 7 - 9 9 - 10 11 - 14 14 - 15 Chapters 10 – 12 13 – 15 16 17 18 - 20 22 Week(s) 1 – 5 6 – 10 11 – 14 15 Pre-lab lectures, 1st Sequence of Experiments Pre-lab lectures, 2nd Sequence of Experiments Team Projects Oral Presentations 10 AM MY 205 12–3 PM MY 205/220 9:30 AM MY 205 Physical Chemistry, Silbey Alberty, and Bawendi 4e, Wiley (2004) Experiments in Physical Chemistry, C. W. Garland, J. W. Nibler, D. P. Shoemaker, 8e, McGraw-Hill (2009) Reading - Students should read all sections of the chapters listed above during the specified time. Quizzes and exams cover reading and lecture material. Problem sets - Students should work all assigned problems to prepare for quizzes and exams. Selected problems will be graded. One quiz or problem set will be dropped. Problem Sets and Quizzes (7 of 8) Two Mid-Term Exams Lab Reports Final Exam, (registrar's schedule) 85-100% = 70-84% = 55-70% = 40 - 55 % = < 40 % = 20 % 40 % 20 % 20 % 100 % 75 ABCDF Instructor Information: Chemistry 3711 Inorganic Chemistry 1 Syllabus Fall 2011-12 Dr. Susan Bates Meyer 264 Dr. Bradley Wile Meyer 265 772-2341 772-2986 s-bates@onu.edu b-wile@onu.edu Text: Course Outline: Descriptive Inorganic Chemistry, 2nd edn; James E. House & Kathleen A. House. Elsevier/Academic Press; ISBN 978-0-12-088755-2 You are expected to read chapters 1 and 2 as a brief introduction to the discipline of inorganic chemistry, and a review of a few Introductory Chemistry topics. From there we will focus on the following areas: Grading: Assignments: Assignment Quizzes Exam 1 Exam 2 Class Participation Final Exam (12/14/11) Coordination, Organometallic, and Transition Metal Chemistry Solid State Chemistry Descriptive Inorganic Chemistry Chapters 18 - 21 Chapter 3 plus additional material Selected Topics TBA, chapters 5 - 17 % Range 85 – 100% 70 – 84% 60 – 69% 50 – 59% < 50% % of Total Grade Letter 20% A 20% B 20% C 10% D 30% F Each quiz will count equally. Your class participation grade will be determined, in part, by consideration of your informed and constructive involvement in class discussions and interactive class activities. The final exam is scheduled by the Registrar (W, 12/14/11, 10:45 am – 1:15 pm), and will be cumulative and comprehensive. Chem 3751 Syllabus Inorganic Chemistry 1 Laboratory Fall 2011 Prof. Susan Bates Meyer 264 x2341 s-bates@onu.edu b-wile@onu.edu Welcome to the laboratory portion of Inorganic Chemistry I (Chem 3711) at Ohio Northern University! This laboratory section meets Thursdays from noon to 2:45 in Meyer Hall 221 (aka “Synthesis Lab”). The experiments chosen for this course have been carefully selected to complement the lecture offerings, and highlight the synthesis, characterization, properties, and applications of inorganic and organometallic compounds. These experiments will be quite different in form and procedure from those you have encountered in Introductory or Organic Chemistry courses at ONU. In addition to the scientific objectives for each experiment, we hope to address aspects of communication in a scientific setting in several ways. First, the practice of keeping good laboratory notebook records throughout your 76 experiments will be critical to later data analysis. These skills translate to the research laboratory, and even to later graduate or professional work. Second, prior to attending lab, you will be asked to prepare a short outline or proposal for the day. Since we only meet once a week for three hours, it is critical that you come prepared and focussed, having already identified areas where you may have questions. Third, you will be asked to communicate the results of your experiments in a variety of ways. As scientists, we have a responsibility to communicate with the general public (not just fellow scientists) in a coherent and intelligible way. To this end, you will be asked to conduct a “peer review” for one lab report, as well as to present some material in a group poster format. We hope that you find these experiments fun, informative, and colorful. Text & Materials There is no formal lab text for this course, but several experiments are drawn from or based upon material in the primary chemical literature, as well as Synthesis and Technique in Inorganic Chemistry, 3rd Edn. by Gregory S. Girolami, Thomas B. Rauchfuss and Robert J. Angelici (available in Dr. Bates’ office, or at the library). References to the chemical literature are presented in the text for each experiment. You are required to wear safety googles and a lab coat at all times in the lab. A bound, quad lined laboratory notebook (carbon copy not necessary) such as those available in the bookstore or from online retailers is required. You may also wish to keep a binder for lab handouts and spectra/data for each experiment. All other materials required to complete each experiment are provided. Prof. Bradley Wile Meyer 264A x2986 Attendance Attendance and completion of all laboratory activities for this course is required. If you must miss a lab as a result of an illness or a University approved function, your are required to notify the instructor(s) well in advance. If it is possible to arrange another meeting outside the scheduled hours for the course, you may do so only when an instructor and/or the TA are present. No unsupervised work of any kind is permitted in the laboratory. A report of some kind (see individual labs, “For Your Report” section) must be submitted to receive any credit for each experiment. Lab sessions are scheduled to run two hours and fourty five minutes, and you should expect each meeting to fill that time. On occasion, a lab session may be slightly shorter than normal, but you should not make appointments on or off campus during the scheduled lab time. On occasion, you may have to set up part of an experiment for the following week. If this cannot be accomplished during the scheduled meeting, and would compromise your ability to perform the subsequent experiment, you may arrange to work outside of lab with the permission of an instructor at least 24 hours in advance. Cleanliness in the Laboratory Out of consideration for the other students using this laboratory please keep shared work areas clean, including capping solvent and reagent bottles, promptly disposing of any waste (as directed in each experiment), brushing solids from balances and benches, and washing/returning all glassware at the conclusion of each laboratory meeting. Cleaning up is part of the experiment! Safety You are expected to read and abide by the safety policies for the Department of Chemistry and Biochemistry, as well as the specific rules for the lab. If you are unsure about any aspect of safety in the lab, please ask your TA or an instructor. Safety glasses must be worn at all times in the laboratory. Any unsafe or inappropriate behavior in the laboratory may be reflected in your grade. Lab Reports & Grading Most lab reports written for this course will be one of two types: short reports, consisting mainly of specific notes and responses to the laboratory activities, with less emphasis on the background and introduction in your written report; and full reports, which include a more in depth discussion of your laboratory activities, including a brief survey of the relevant literature, discussion of the results and sources of error, and suggestions for future improvement. Lab reports are due by the start (i.e. noon) of the lab period indicated. Lab reports should be typed, and relevant spectra/figures should be inserted electronically. In addition to a paper copy, you should compile your report as a .pdf, and upload it to the course WebCT page. Late reports will be penalized at a rate of 1 point deducted per day late (weekends count as one day). Careful notes and sample calculations should be recorded in your laboratory notebook. 77 Your grade for this course will determined using the following point breakdown: Short Reports Full Reports Poster Project Lab Tachnique Lab Final (during in-class final) 50 pts 6 x 20 pts = 120 pts 3 x 50 pts = 150 pts 30 pts 50 pts A 85 - 100% B 70 - 84% C 60 - 69% D 50 - 59% F < 50% Total Academic Honesty 400 pts Date Experiment Reports Due Aug. 25 Sep. 1 Sep. 8 Sep. 15 Sep. 22 Sep. 29 Oct. 6 Oct. 13 Oct. 20 Oct. 27 Nov. 3 Nov. 10 Nov. 17 Nov. 24 Dec. 1 Dec. 8 Introduction to the Lab Safety and Scientific Communication Microscale Synthesis of Vaska’s Complex (week 1) Microscale Synthesis of Vaska’s Complex (week 2) The Paramagnetic Complex Mn(acac)3 The Trans Effect (week 1) The Trans Effect (week 2) Peer Review of Vaska’s Complex Report Preparation of meso-tetraphyenylporphyrin No Lab (Fall Break) Metallation of meso-tetraphyenylporphyrin Collect any outstanding data (including H2TPP) Catalysis Using Metalloporphyrin Characterization of Metalloporphyrin Solid State Models CdSe Quantum Dots Thermochromic Compounds No Lab (Thanksgiving Break) Work on Posters Collect any outstanding characterization data Poster Presentations Checkout Vaska’s Complex (preliminary draft, full report) Vaska’s Complex (final draft, full report) The Trans Effect (full report) Solid State Models Worksheet Preparation and Metallation of a Porphyrin (full report) Mn(acac)3 Poster Proposal CdSe Quantum Dots Poster Due (Tuesday) Thermochromic Compounds Ohio Northern University students have an obligation to maintain the highest standards of ethical conduct. This guideline applies to all examinations and written work, including laboratory reports, submitted for a grade. If you find yourself questioning whether an action might be considered academic dishonesty, chances are that it is. Students are encouraged to discuss experimental data and work together, though material to be turned in for a grade is to be completed independently (except where noted). Spring 2011-12 CHEM 4001 Course Syllabus Capstone 3 Coordinator/Instructor: Dr. Susan Bates s-bates@onu.edu 772-2341 MY 264 Course Objectives: Each student will prepare a seminar on a current topic in chemical research. The seminar will be presented to an audience of departmental faculty and students. The student will have an opportunity to demonstrate their ability to search the chemical literature, utilize their previous coursework to understand the material, organize material from various sources and deliver this information orally. Grading: Assignment Literature Search Outline Slide Rough Draft Practice Seminar Seminar Performance % of Total Letter 15 A 20 B 15 C 10 D 40 F %Range 85 - 100 70 - 85 60 - 69 50 - 59 < 50 Late work on all parts (except E) is penalized at the rate of 2% per day. No work will be accepted after May 4, 2012. Assignments (see table below for individual student assignment due dates): Part A 78 Part B Part C Part D Part E Identify your topic. Read 10-20 articles on the topic. Develop your seminar’s theme. Provide the full text of five key articles as .pdf files to both of your faculty mentors. Three of these five articles must be among the following: any ACS journal (excluding reviews), Journal of Chemical Physics, Chemical Physics Letters, or other journals approved in advance by Dr. Bates. Prepare an outline for your presentation and paper and submit it to both of your faculty mentors. Prepare a rough draft of the slides for your talk and review this with both of your faculty mentors. Write an abstract for your seminar and submit it to both of your faculty mentors. Practice your seminar in front of both of your faculty mentors and possibly other invited faculty and students. Publicize your seminar with flyers and an email at least three days before the talk. Deliver your 45-minute seminar before the department. All assignments should be submitted electronically (e.g. .pdf or .doc) 79 ASTRONOMY Physics 1051 INSTRUCTOR: Dr. William Theisen, 109 Sci Annex, x2741, hours TBA. TEXT: Chaisson, Mc Millan, Astronomy Today, 7th ed. GRADES: Grades will be based on the following: 1) Class assignments ( ~5 %). Due to the interactive nature of the course, class participation is encouraged and expected. 2) Observation of the evening sky will take place several times, attendance is expected. 3) The total number of points earned on quizzes, exams, and class assignments. Quizzes and exams will be given on Friday of each week. Grades should expect to go 90%, 80%, ..... TENTATIVE SCHEDULE: This listing gives a sequence of topics with approximate timing. Week 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 Chapter(s) 1 1 1, 2 3, 4 5 6 7, 8 8 8 9 10 11 12 14, 15 16, 20 26 Material Exam Schedule Constellations I Constellations II , History Quiz 1 (20) Seasons, Parallax, Kepler, Newton, Gravity E&M Radiation, Spectroscopy EXAM 1 (100) Telescopes Solar System Quiz 2 (20) Earth Moon EXAM 2 (100) Mercury Venus Quiz 3 (20) Mars Jupiter EXAM 3 (100) EXAM 4 (100) Saturn, Uranus, Neptune Pluto and beyond, Solar System Models Stellar Evolution Cosmology Comprehensive Final FINAL (150) 80 FINAL EXAM: Comprehensive, Wednesday, December 14, 8:00 - 10:30 (No Early Finals) Academic Dishonesty: As expected, the policy can be found in the Student Handbook. Ohio Northern University General Physics 1 - Physics 2111 Section 01 CRN20765 Section 02 CRN20766 Fall Semester, 2011 - 2012 Syllabus Instructor: professor Maria Cristina Sheridan E-mail: m-sheridan@onu.edu Office: Science Annex 110 Officehours: Mon1-2pm, Wed1-2pm Office phone: 419 772 3096 Course Hours: Section 01: Mon Wed Fri 11 - 11:50 pm; room: Meyer 114 Section 02: Mon Wed Fri 12 - 12:50 pm; room: Meyer 114 Textbook: College Physics ISBN: 978-0-321-60183-4, 7th edition, by J. A. Wilson and A. J. Buffa is sold to students through the University Bookstore, which is located on the first floor of the McIntosh Center. Course Content: Part 1: Mechanics (Chapters 1 - 9) Part 2: Oscillations and Waves (Chapters 13 -14) Part 3: Thermodynamics (Chapters 10 - 12) I plan to cover Chapters 1 - 14, but some sections and/or parts of some sections may be omitted. A good understanding of algebra and trigonometry will be used through out the course and will be quite useful for the course. Tentative Schedule: Week 4 Week 9 Week 13 Week 17 Grading: Test #1 Test #2 Test #3 FINAL Ch. 1 - 3 Wed, regular class time and place Ch. 4 - 8 Wed, regular class time and place Ch. 9, 13 - 14 Wed, regular class time and place Ch. 1 - 14 tba 75 points - Final Exam 150 points - Tests 25 points - Quizzes A total number of points of 250 corresponds to 100% overall. Your overall percentage will be (N/250) x 100%, where N is your total number of points. Grades are assigned as follows: 90% or greater ...............A 80% - 89%.....................B 70% 79%.....................C 60% - 69%.....................D Below 60%.....................F Tests: You will be allowed to use a calculator during the tests. The tests will contain some problems or questions that are similar to the homework exercises, class and book examples. Final Exam: You will be allowed to use a calculator during the final exam. The exam will contain some problems or questions that are similar to the homework exercises, class and book examples. The final is cumulative and you cannot be excused from it. Final Exam Make-up policy: There will be NO make-up for the final exam. Absences from final examinations will result in the final examination grade being calculated as a failure in determining the final course grade. Homework: The homework assignments are available online on WebCT . Please do your HW regularly. Some of the test/exam questions may be similar (although not necessarily identical) to the homework questions. Quizzes: There will be some in-class quizzes and some online quizzes. In-class quizzes will be given on Wednesdays. Quizz dates for online quizzes will be announced in class or by e-mail. Online quizzes will be available on WebCT. Take the online quizzes on-campus at the library. 81 Materials allowed for the quiz are: calculator, pencil/pen, blank paper, and the “potentially useful information”. You will be allowed two attempts per quiz. Attendance: All students are expected to attend all classes, quizzes, tests and final exam and to be on time. In case of an absence from a test, the student is responsible for contacting me by email (preferably before 7 pm the day before test day and no later than 9 am test day). Academic Misconduct: I trust that all my students are honest people whose best efforts are centered on studying not on cheating and that I will not need to enforce the university’s policy on academic dishonesty. You are not to discuss the contents of the tests until they are returned to you. Available Support Services: Tutoring is available free of charge through the Physics Department. Should there be any changes to this syllabus, I will let you know. Welcome to Physics 2111 and I wish you a wonderful year here at ONU! Course Expectations Physics 2111- Section 3 General Physics 1 Fall Semester, 2011-2012 Instructor: Dr. Mellita Caragiu Office: 114 Science Annex Office phone: 772-2851 E-mail: m-caragiu@onu.edu Course hours: M, W, F 10-10:50am, room: Meyer 203 Office hours: M, W, F 11am-12pm, M, W 2-2:50pm Text: College Physics, 7th edition, by J. D. Wilson, A. J. Buffa and B. Lou Course content: we will cover Chapters 1-14, but some sections and/or parts of some sections may be omitted. Exams: There will be 4 in-class exams. The exams are to take place on Friday, at the end of weeks 3, 6, 9, and 12. Your lowest grade will be dropped. Exams are worth 75% of your grade. Final exam: The final exam is on Wednesday, December 14, at 6:30pm, and it is worth 25% of your grade. The final is cumulative and you cannot be excused from it. Homework: Homework will be assigned almost every day. The exam questions will be very similar to the homework questions, so make sure you do your HW carefully. Grading: Grades are assigned as follows: 90% or greater………A 80-89% ……………..B 70-79%.......................C 82 60-69%.......................D Below 60%.................F Academic dishonesty will not be tolerated; for policy regarding academic conduct, please see the Student Handbook. Ohio Northern University Department of Physics Physics 1: Mechanics Fall Semester 2011 PHYS 2311-01 Dr. B.E. Johansen Syllabus Instructor: Dr. B.E. Johansen , SciAn 113/phone 3008, Home Phone 419-649-7007 (available to 11:00 pm), Office hours 8:00 a.m. T, F: 2-4:00 p.m. Th or by appointment. Text: Serway/Jewett: Physics for Sci. and Eng., 8th ed, Thomson Brooks-Cole 2010 Departmental description: Classical Newtonian mechanics and thermodynamics employing integral and differential calculus. Instructor objective: Develop the science and methodology of mechanics and thermodynamics for application to problems and further study of physics. Course coverage: Kinematics and dynamics of particles and rigid bodies; mechanical waves: thermodynamics. Parts 1, 2 and 3 of the text. Graded work: 1. Homework: Objective Questions and Problems will be assigned daily. Presentation format needs to be justifiable. Work will be collected each Friday and evaluated on a 10 pt basis. Collaboration is encouraged. Copying is unacceptable. Questions involving homework are encouraged. 2. Quizzes: Quizzes are on Friday. They are of a nominal length of 10 min. Quizzes are graded on a 10 pt basis and equal weight to a homework set. 3. Hour exams: There are four hour exams scheduled on the third and sixth and ninth and twelfth Fridays of the semester. The lowest exam will be dropped. Make-up exams for extenuating circumstances are by prior approval of the instructor. 4. Final Exam(required) is scheduled by the Registrar, Friday Dec 16, 8:00 a.m. Calculator policy: Some test work may prohibit the use of calculators. Conduct: Appropriate collegiate decorum as guided policy in student handbook. Course grade: The following represents the weighting of the components of the graded work: Homework and quizzes 50 pts Hour exams 300 pts 83 Final exam 150 pts Final course grade A > 449 pts, 450 pts>B>399pts, 400 pts>C>349pts, 350pts>D>299pts, F<300pts Ohio Northern University Department of Physics Physics 2: Electricity/Magnetism Fall Semester 2011 PHYS 2321- 01 / 03 Dr. B.E. Johansen Syllabi Instructor: Dr. B.E. Johansen ,SCIANX 113/phone 3008, Home Phone 419-649-7007 (available to 11:00 pm), Admin. Assit. 2320 1:00/4:30 M/F. Office hours: 8:00 a.m. W, F; 2:00 M, Th or by appointment. Text: Serway/Jewett: Physics for Sci. and Eng., 8th ed, Thomson Brooks-Cole 2010 Departmental objective: Competence (level set by the text) in classical electrical and magnetic phenomena. Integral and differential calculus based. Instructor objective: Develop and apply the electrical and magnetic concepts and laws leading to Maxwell’s equations. To investigate various current applications of the phenomena. Course coverage: Electrostatics, Circuits, Magnetostatics, and Electrodynamics are the topics in Part 4 of Serway and Jewett. See attached schedule for timing. Graded work: 1. Homework: Problems and exercises will be assigned daily. Work will be collected each Friday and evaluated on a 10 pt basis. Format is required. Collaboration is encouraged. Copying is unacceptable. Questions involving homework are encouraged. 2. Quizzes: Quizzes are on Friday. They are of a nominal length of 10 min. Quizzes are graded on a 10 pt basis and equal weight to a homework set. 3. Hour exams: There are four hour exams scheduled on the third and sixth and ninth and twelfth Fridays of the Quarter. The lowest hour exam will be dropped. Make-up exams for extenuating circumstances are by prior approval of the instructor. 4. Common Final time to be announced Calculator policy. Some test work may prohibit the use of calculators. Attendance Policy: After three absences the academic advisor will be notified. Conduct : Appropriate collegiate decorum guided by policy in the student handbook. Course grade: The following represents the weighting of the components of the graded work: Homework and quizzes 50 pts Hour exams 300 pts Final exam 150 pts Final course grade A > 449 pts, 450>pts>B>399pts, 400pts>C>349pts, 350pts>D>299pts, F<300pts 84 . PHYS 2321-02 - Physics 2, Autumn 2011 Teacher: Dr. Terry Sheridan, 109B Science Annex, ext. 2739, t-sheridan@onu.edu Text: Serway & Jewett, Physics for Scientists & Engineers, 8th ed. Lecture: MWF: 10:00-10:50, 114 Meyer. Office hours: See attached schedule. You can also see me by appointment and anytime I’m not busy (look in the Plasma Lab). Course description: Electric and magnetic phenomena. Optics. Differential and integral calculus are used. The corresponding laboratory is PHYS 2351. Attendance: Is required. If you are going to be absent let me know (e-mail is best). Coming to class is one of the easiest ways to learn physics. Homework: There will be one HW assignment per week, due on Monday. Selected problems will be graded. Grading is on a two point system: 2 - mostly correct, 1 - good start, obvious problems, 0 - didn’t attempt, completely lost. HW is where you practice doing physics. Tests: See attached schedule. The test will consist of fill-in-the-blanks, definitions and problems. NO calculators, NO notes. Final Exam: Comprehensive. Wednesday, Dec. 14, 6:30-9 pm. NO calculators, NO notes. Academic Honesty: Don’t cheat. This means that your homework assignments are substantially your own work, and not copied directly from any other source. For quizzes, tests and exams, this means you didn’t cheat. Grades: Grades will be based on HW (10%), tests (3 x 20%), and the final exam (30%). The scale will be: A > 90%, 80% < B < 90%, 70% < C < 80%, 60% < D < 70%, F < 60%. Attachments: 1) Course schedule with homework assignments, 2) homework format, 3) my schedule. PHYS 2351 - Physics Laboratory 2, Fall 2011 Teacher: Dr. Terry Sheridan, 109B Science Annex, ext. 2739, t-sheridan@onu.edu Text: Experiments in Electricity and Magnetism ($12), lab books ($2), cash, Physics Office Lab meeting: Sect. 02: Thursday 12:00 to 2:45 in 122 Meyer Office hours: M, F 11-12 and 1-2, Th 3-4, and by appointment. Course description: Experiments in electricity and magnetism, and optics. PHYS 2121 or 2321 should be taken concurrently, or instructor's permission must be obtained. Offered fall and spring semesters. 1.000 Credit hours Attendance: Is required. Missed labs are hard to make up. Youmust tell me if you are going to miss a lab, send me an e-mail, and arrange a make-up time. Academic honesty: Each student is responsible for their own lab report–the material in your lab report should be substantially your own work (except for common data), and not copied directly from any other source. Grading: Lab grades are determined as follows. Each lab report begins at 8.5 points. No pre-lab is -3 pts. Points will be subtracted in 0.5 pt increments for things such as: missing units, errors, unsupported statements, illegible writing... Points will be added in 0.5 pt increments for things such as: excellent work, added insights, very good results, demonstrated understanding of lab, thoroughness... Grades: Grades will be based on lab reports (10 labs at 10 pts apiece) and formal lab (30 pts). Thescalewillbe: A>90%,80%<B<90%,70%<C<80%,60%<D<70%,F<60%. 85 Week Special Group I Group II 1 Organizational meeting 2 Mapping E (exp’t) Mapping E (computer) 3 Mapping E (computer) Mapping E (exp’t) 4 Millikan charge R in series and parallel 5 R in series and parallel Millikan charge 6 RC circuit Oscilloscope 7 Oscilloscope RC circuit 8 Plotting B Magnetic field balance 9 Formal lab proposal due Magnetic field balance Plotting B 10 Charge-to-mass Motors and generators 11 Motors and generators Charge-to-mass 12-16 Formal lab work Formal lab Formal lab 3051 – MODERN PHYSICS INSTRUCTOR: Dr. William Theisen, 109 Sci Annex, x2741, hours TBA. 86 TEXT: K. Krane, Modern Physics, 2nd Ed. GRADES: Grades will be based on the following: 1) Class assignments( ~5 %). Due to the interactive nature of the course, class participation is encouraged and expected. 2) Observation of the evening sky will take place several times, attendance is expected. 3) The total number of points earned on quizzes, exams, and class assignments. Quizzes and exams will be given on Friday of each week. Grades should expect to go 90%, 80%, ..... TENTATIVE SCHEDULE: This listing gives a sequence of topics with approximate timing. Week 1 2 3 4 Chapter(s) 1 2 2 16 5 3 6 7 8 9 10 11 12 13 14 15 16 4 5 5 6, 7 6, 7 8, 9 12, 13 14 14 14 16 Material Classical Physics Special Relativity I Special Relativity II General Relativity Exam Schedule Quiz 1 (20) Test 1 (100) Light as Particles Electrons as Waves The Schrödinger Equation The Schrödinger Equation Bohr Atom, Hydrogen Atom I Bohr Atom, Hydrogen Atom II Atomic Physics Nuclear Physics Elementary Particles I Elementary Particles II Elementary Particles III Quiz 2 (20) Quiz 3(20) Test 2 (100) Quiz 3(20) Test 3 (100) Cosmology Comprehensive Final FINAL (150) FINAL EXAM: Comprehensive, Wednesday, December 14, 8:00 - 10:30 Academic Dishonesty: As expected, the policy can be found in the Student Handbook. 87 Course Expectations Physics 3451-01 - Mathematical Methods in Physics Fall Semester, 2011-2012 Instructor: Dr. Mellita Caragiu Office: 114 Science Annex Office Phone: 772-2851 E-mail: m-caragiu@onu.edu Course Hours: M,W, F 3-3:50 pm; room: Science Annex 116 Office Hours: M, W, F 11am-12pm; M, W 2-2:50pm Text: Mathematical Methods in the Physical Sciences, 3rd edition, by Mary L. Boas Course Content: We will cover selected sections of Chapters 3, 6, 7, 8, 10, 12. List of topics: 1. a) b) c) d) Vector analysis operations with vectors (scalar product, vector product, differentiation of vectors); unit vectors; fields (scalar fields and vector fields); directional derivative; gradient; e) divergence and the divergence theorem Vd volume τ f) curl and Stokes’ theorem curve bounding σ g) conservative fields V dr V nd ; surface inclosing τ V nd ; surface σ if V 0 then V . 2. Coordinate transformations 3. Tensor analysis 4. Determinants and matrices (linear algebra) a) special matrices (unit matrix, null matrix, singular matrix, hermitian matrix, adjoint matrix…); b) orthogonal transformations; c) eigenvalues and eigenvectors; d) diagonalizing matrices. 88 5. a) b) c) Series solutions of differential equations Legendre’s equation; Orthogonal functions; Hermite polynomials. 6. Fourier series Exams: There will be 4 in-class exams. The exams are to take place on Friday, at the end of weeks 3, 6, 9, and 12. Your lowest grade will be dropped. Exams are worth 50% of your grade. Homework: You will have to read, in advance, assigned sections from the textbook! There will also be problems assigned at the end of most of the class periods. The homework is worth 25% of your grade. Final exam: The final exam is on Wednesday, December 14, 2-4 pm and is worth 25% of your grade. The final is cumulative and you cannot be excused from it. Grading: Grades are assigned as follows: 90% or greater………A 80%-89%……………B 70%-79%……………C 60%-69%……………D Below 60%…………..F Academic dishonesty will not be tolerated; for policy regarding academic conduct, please see the Student Handbook. PHYS 4111 - Electricity & Magnetism 1, Autumn 2011 Teacher: Dr. Terry Sheridan, 109B Science Annex, ext. 2739, t-sheridan@onu.edu Text: D. J. Griffiths, Introduction to Electrodynamics, 3rd ed. Lecture: 9:30 to 10:45 a.m., Tues and Thurs., 201A Science Annex Office hours: see attached schedule, by appointment, and anytime I’m not busy. 89 Course description: Electrostatic field theory, capacitance, multipole expansion, dielectric properties of matter; magnetic field theory; electromagnetic induction; magnetic properties of matter; Maxwell's equations and electromagnetic waves. Offered alternate fall semesters. Attendance: Is required. If you are going to be absent let me know. Coming to class is the easiest way to start learning E&M. Academic honesty: Don’t–it’s wrong. For homework this means that your work is substantially your own and has not been copied directly from any other source. Homework: There will be HW for Chs. 2, 3, 5, and 7. Each problem will be grading on a 2 point system: 2 - knew what you were doing, maybe minor errors, 1 - got a good start, made some progress, wrong/no units or significant figures, 0 - no progress. Exams: Midterm and final. The final is comprehensive. No calculators, no notes. Final examine 8:00-10:30 am, Thursday, Dec. 15.. Grades: Grades will be based on HW (30%), midterm exam (30%), and the final exam (40%). The scale will be: A > 90%, 80% < B < 90%, 70% < C < 80%, 60% < D < 70%, F < 60%. 90