REVIEW/STUDY GUIDE FOR EXAM 1 Chapter 1 definitions: anatomy, physiology hierarchy of levels: molecules, cells, tissues, etc. (types of tissues, 11 systems) what are the 6 life functions? what is homeostasis? How do negative and positive feedback loops function? examples of each. Anatomical position; body directional and regional terminology Know all body planes & cavities (examples of organs in each cavity) All membranes: which layers are visceral, parietal, examples of each Chapter 2 definitions of matter & energy (potential & kinetic) Atoms: protons, neutron, electrons, atomic # Elements - 4 main elements of human body Covalent, ionic, and hydrogen bonds characteristics of each Solutions, solvents, solutes, what is the main solvent in the human body? Chemical reactions: dehydration synthesis, hydrolysis, exchange, oxidation/reduction - Factors effecting rate of reactions i.e. particle size, temp, concentration, catalysts Biochemistry: Inorganic compounds - characteristics of acids & bases. what does each release in solution? how does each effect pH? - pH scale and H+ ion concentrations , pH<7 or pH >7 indicates? Organic compounds - carbohydrates: what are monosaccharides, what are disaccharides? (what monosaccharides form them?) what are the types of polysaccharides? what is the main function of CHOs? each gram of CHO provides ___ kcal? - lipids: are insoluble in_____? each gram of fat provides ___ kcal? Triglycerides are hydrolyzed into? functions of lipids? - proteins: functions (structural and functional) 4 kcal/gram. how many amino acids are there? what are the characteristics of amino acids? what are peptide bonds? what are the 4 levels of protein structure? characteristics of fibrous & globular proteins and examples of each. how are proteins denatured? - nucleic acids: DNA & RNA characteristics and differences. structure of a nucleotide: bases, sugars, and phosphate ATP: function ADP/ATP reaction Chapter 3 Structure of the plasma membrane. what is the purpose of cholesterol? why are the phospholipids important? what are the functions of the cell membrane? types of proteins (integral vs. peripheral) found in cell membrane and functions Glycocalyx: what is it, functions of it, & what are glycoproteins? why are they important? Membrane junctions: types & characteristics of each What are villi and microvilli? what do they do? Understand the movement of materials into/out of the cell & examples of each: diffusion, facilitated diffusion, filtration, osmosis, active transport processes (endocytosis, receptormediated endocytosis, exocytosis, sodium-potassium pump) What sustances should not leave via filtration? Tonicity: what happens to red blood cells when placed in isotonic, hypertonic, & hypotonic solutions? Organelles -functions of ribosomes, mitochondria, rough vs. smooth endoplasmic reticulum, golgi apparatus, lysosomes, perioxisomes, centrioles Nucleus and components, what does the nucleolus do? what is chromatin? what can and cannot pass through the nuclear envelope? Why? Cell reproduction: mitosis: all phases, be able to identify stages on slides. What are oncogenes? definition of a tumor, benign, malignant, which are cancerous? what does that mean? DNA replication and protein synthesis all phases: know triplets, codons, anticodons, what happens during transcription? and translation? what does DNA polymerase and DNA ligase do? and RNA polymerase. Types & functions of RNA Chapter 25 – Metabolism Anabolic vs. Catabolic Oxidation-reduction reactions, what happens? Substrate-level phosphorylation and oxidative phosphorylation which produces the most ATP, where do each occur? CHO Metabolism: glycolysis to TCA (Krebs) cycle to ETC: all end products of each, # ATP produced for each and total What hormone is necessary for glucose to enter a cell? how does it enter the cell? what is the importance of the first step (forming glucose six phosphate?), how many NADH molecules formed during glycolysis? how many during the TCA cycle? Where is FADH2 formed? How many ATP does the ETC form for every FADH2? and NADH? Definitions of glycogenesis, glycogenolysis, gluconeogenesis: which organ stores the most glycogen? where does gluconeogenesis occur? know when each of these would happen Lipid Metabolism: glycerol and FA metabolism: all as discussed in class how is glycerol broken down? and fatty acids? how many ATP from each? lipogenesis, lipolysis, ketones (prod. from rapid lipolysis) what is the problem with the ketones? Protein Metabolism: oxidation of AA, where occurs: by products- what happens to them? How are AA stored? Be familiar with the diagrams Chapter 28 meiosis: the end result? how is it different from mitosis? how similar? what happens? What are the sequence of events that occur during spermatogenesis and oogenesis? Where does oogenesis occur? when does it begin? when does it stop? what are the end products for it? Steps in the ovarian cycle Where does spermatogenesis occur? when does it begin? what are the end products? Chapter 29 Development: What happens at fertilization? Look at the development from a fertilized egg (first cleavage division) through blastocyst and implantation. Know DNA structure; chromatin vs. chromatid Define genotype and phenotype, and dominant and recessive Be able to predict inheritance by using a punnett square What is involved with genetic variation: why does it happen? What is sex linked inheritance? What diseases/disorders are associated with it? Describe the Human Genome Project; what advances have been made in the past decade?