Виконавець - доцент Мудра А.Є.
Кафедра біохімії
Module – 2
Pharmaceutical faculty
1.Coenzyme of amino acids decarboxylases is:
A. Thymidine diphosphate
B. Flavin adenine dinucleotide
C. Flavin mononucleotide
D. HS-CoA
E. PLP
ANSWER: E
2.The amino acids abstracted from the liver are not utilized for repair or
special synthesis but are broken down to
A. Keto acids
B. Sulphur dioxide
C. Water
D. Ammonia
E. A and D
ANSWER: D
3.The amount of general acidity in gastric juice of a patient P. is normal.
Which of the listed numbers is true in this case?
A. A.30-40 mM/l
B. B.40-60 mM/l
C. 20-30 mM/l
D. 30-50 mM/l
E. 20-40 mM/l
ANSWER: B
4.As a result of amino acids decarboxylation in the organism are formed:
A. Ammonia, urea, creatine
B. Amines, diamines
C. Polypeptides, uric acid
D. Dipeptides, xanthine
E. Amines, indican
ANSWER: B
5.In case of severe denaturation of protein, there is
A. Reversible denaturation
B. Moderate reversible denaturation
C. Irreversible denaturation
D. B and C
E. None of these
ANSWER: C
6.In the stomach act such proteolytic enzymes:
A. Trypsin, chymotrypsin
B. Pepsin, enterokinase
C. Trypsin, renin
D. Pepsin, gastrixin, rennin
E. Chymotrypsin, enterokinase
ANSWER: D
7.Insufficiency of which vitamin does cause the inhibition of activity of
aminotransferase’s and decarboxylase?
A. B3
B. B2
C. B6
D. B12
E. B15
ANSWER: A
8.Negative nitrogenous balance is observed in all listed cases, except:
A. Kidney disease
B. Domination of animal proteins in food
C. Domination of vegetable proteins in food
D. In old age
E. Pancreatitis
ANSWER: B
9.The main enzymatic reaction requiring pyridoxal phosphate as a coenzyme is :
A. Decarboxilation
B. Transamination
C. Deamination
D. Reamination
E. Oxidation
ANSWER: B
10.The main sites for oxidative deamination are
A. Liver and kidney
B. Skin and pancreas
C. Intestine and mammary gland
D. Lung and spleen
E. All of these
ANSWER: A
11.The major site of urea synthesis is
A. Brain
B. Kidneys
C. Liver
D. Muscles
E. Both B and C
ANSWER: C
12.The milk protein in the stomach of the infants is digested by
A. Pepsin
B. Trypsin
C. Chymotrypsin
D. Rennin
E. All of the above
ANSWER: D
13.Which pathological component appears in the gastric juice in cancer of the
stomach?
A. Lactic acid
B. Hydrochloric acid
C. Acetic acid
D. Sulfuric acid
E. Citric acid
ANSWER: A
14.Genetic information in human beings is stored in
A. DNA
B. RNA
C. Both (A) and (B)
D. ATP
E. None of these
ANSWER: A
14.Gout is a metabolic disorder of catabolism of
A. Pyrimidine
B. Purine
C. Alanine
D. Phenylalanine
E. Both A and B
ANSWER: B
15.DNA does not contain
A. Thymine
B. Adenine
C. Uracil
D. Deoxyribose
E. Both C and D
ANSWER: C
16.Which of the following is not an amino acid?
A. Glutamic acid
B. Aspartic acid
C. Glutamine
D. Palmitic acid
E. Leucine
ANSWER: D
17.Transcription is the formation of
A. DNA from a parent DNA
B. mRNA from a parent mRNA
C. pre mRNA from DNA
D. protein through mRNA
E. protein through DNA
ANSWER: C
18.Translation is the formation of
A. DNA from DNA
B. mRNA from DNA
C. Protein through mRNA
D. mRNA from pre mRNA
E. Protein through DNA
ANSWER: C
19.A drug which prevents uric acid synthesis by inhibiting the enzyme Xanthine
oxidase is
A. Aspirin
B. Allopurinal
C. Colchicine
D. Phenyl benzoate
E. All of these
ANSWER: B
20.Amount of uric acid which excreted daily is:
A. Not excreted
B. 10-12 g/day
C. 4-8 mg/day
D. 270-600 mg/day
E. 2-5 g/day
ANSWER: D
21.Choose the substance which gives the most atoms for purine ring:
A. aspartate
B. glycine
C. glutamine
D. formyl -THF
E. CO2
ANSWER: B
22.Gout is characterized by increased plasma levels of
A. Urea
B. Uric acid
C. Creatine
D. Creatinine
E. Ammonia
ANSWER: B
23.Name the structural monomers of DNA molecule:
A. Mononucleotides
B. Nucleosides
C. Nitric bases
D. Polynucleotides
E. Peptides
ANSWER: A
24.The double strand model of DNA was proposed by:
A. Mitchel
B. Krebs
C. Watson – Crick
D. Knoop
E. Nirenberg
ANSWER: C
25.A dysfunction of Langergans islets results in the decline of such hormones:
A. Glucagon and insulin
B. Thyroxin and calcitonin
C. Insulin and epinephrine
D. Callicrein and angiotensin
E. Parathormone and cortisol
ANSWER: A
26.A man after 1,5 litres blood loss has suddenly reduced diuresis. The
increased secretion of what hormone caused such diuresis alteration?
A. Corticotropin
B. Natriuretic
C. Parathormone
D. Cortisol
E. Vasopressin
ANSWER: E
27.A patient has such sympthoms as hyperglycaemia, glucosuria, increased urine
density, thirst, acidosis. What from below mentioned disorders can result in
such state?
A. Insufficiency of insulin
B. Hyperproduction of insulin
C. Insufficiency of vasopressin
D. Hyperproduction of glucocorticoids
E. Insufficiency of glucagon
ANSWER: A
28.After meal an alimentary hyperglycemia stimulates the secretion of such
hormone:
A. Cortisol
B. Glucagon
C. Epinephrine
D. Norepinephrine
E. Insulin
ANSWER: E
29.Dopamine is biogenic amine which is intermediate in a synthesis:
A. Epinephrine and Norepinephrine
B. Serotonin
C. Serotonin and melatonin
D. Insulin
E. All of above correct
ANSWER: A
30.Effect of insulin on a carbohydrate metabolism is:
A. Activates transfer of glucose through the cells membranes
B. Activates glucokinase
C. Activates glycogensynthase
D. Activates a gluconeogenesis
E. Inhibits transfer of glucose through the cells membranes
ANSWER: A
31.Epinephrine increases the glucose level in the blood by activation of:
A. glycogenolysis
B. glycolysis
C. ketolysis
D. gluconeogenesis
E. glycogenesis
ANSWER: A
32.Name the hormone, predominantly produced in response to fight, fright and
flight:
A. Thyroxine
B. Epinephrine
C. Aldosterone
D. ADH
E. Insulin
ANSWER: B
33.The chemical nature of tropic hormones of adenohypophysis is:
A. Simple proteins
B. Glycoproteins
C. Lipoproteins
D. Derivates of fatty acids
E. Derivates of amino acid
ANSWER: B
34.The patient complains of polyuria. The pathological components in urine are
not detected. The deficiency of what hormone can result in such state?
A. Insulin
B. Glucagon
C. Epinephrine
D. Vasopressin
E. Cortisol
ANSWER: D
35.The patient with diabetes mellitus has hypoglycemic coma. The reasons for
this can be:
A. overdosage of insulin
B. starvation
C. dehydration of the organism
D. pancreatic islet ?-cells adenoma
E. Addison's disease
ANSWER: A
36.What are effects of the rennin-angiotensin system action?
A. Vasoconstriction, oppression of secretion of aldosteron
B. Vasoconstriction, stimulation of secretion of aldosteron
C. Relaxion of vessels, oppression of secretion of aldosteron
D. Relaxionof vessels, stimulation of secretion of aldosteron
E. Stimulation of reabsorption of sodium and potassium in kidney tubulis
ANSWER: B
37.What biochemical symptoms are specific for diabetes mellitus?
A. Hyperglycemia, glucosuria, decreased urine density
B. Hypoglycemia, glucosuria, increased urine density, acidosis
C. Hypoglycemia, glucosuria, normal urine density
D. Hyperglycemia, glucosuria, decreased urine density, acidosis
E. Hyperglycemia, glucosuria, increased urine density, acidosis
ANSWER: E
38.What is the chemical nature of catecholamins?
A. Proteins
B. Peptids
C. Derivatives of amino acid
D. Steroids
E. Derivatives of arachidonic acid
ANSWER: C
39.Choose a male sex hormone:
A. Estradiole
B. Testosterone
C. Cortizon
D. Progesterone
E. Cortikosterone
ANSWER: B
40.Cortisol is produced by the:
A. Adrenal cortex
B. Adrenal medulla
C. Pancreas
D. Thyroid gland
E. Salivary gland
ANSWER: A
41.Hormone that stimulates testosterone production:
A. Luteinizing hormone
B. Follicle stimylating hormone
C. Growth hormone
D. Melanocitostimulating hormone
E. Thyroid hormones
ANSWER: A
42.Hypofunction of thyroid gland in adults results in:
A. A. Cretinism
B. B. Dwarfing
C. C. Toxic goiter
D. D. Mixedema
E. E. Acromegalia
ANSWER: D
43.Hypofunction of thyroid gland in children results in:
A. A. Gigantism
B. B. Graves disease
C. C. Toxic goiter
D. D. Dwarfing
E. E. Cretinism
ANSWER: E
44.Name hormone that stimulates the synthesis of milk proteins:
A. Luteinizing hormone
B. Prolactin
C. Thyroid stimulating hormone
D. Growth hormone
E. Follicle stimulating hormone
ANSWER: B
45.Which hormone has steroid nature?
A. Calcitonine
B. Parathormone
C. Norepinephrine
D. Epinephrine
E. Estron
ANSWER: E
46.Anti-egg white injury factor is:
A. Pyridoxine
B. Biotin
C. Thiamin
D. Liponic acid
E. All of these
ANSWER: B
47.Daily requirement of vitamin C in adults is about:
A. 100 mg
B. 25 mg
C. 70 mg
D. 100 mg
E. 70 g
ANSWER: C
48.Deficiency of Vitamin A causes
A. Xeropthalmia
B. Hypoprothrombinemia
C. Megaloblastic anemia
D. Pernicious anemia
E. Beri-Beri
ANSWER: A
49.Deficiency of vitamin B12 can occur because of:
A. Decreased intake of vitamin B12
B. Atrophy of gastric mucosa
C. Intestinal malabsorption
D. All of these
E. None of these
ANSWER: D
50.Deficiency of vitamin C causes:
A. Beriberi
B. Pellagra
C. Pernicious anaemia
D. Scurvy
E. Both A and D
ANSWER: D
51.Deficiency of vitamin D causes
A. Rickets and osteomalacia
B. Tuberculosis of bone
C. Hypothyroidism
D. Skin cancer
E. Cretinism
ANSWER: A
52.Pellagra is caused due to the deficiency of:
A. Ascorbic acid
B. Pantothenic acid
C. Pyridoxine
D. Niacin
E. C and D
ANSWER: D
53.Scurvy is caused due to the deficiency of
A. Vitamin A
B. Vitamin D
C. Vitamin K
D. Vitamin C
E. B and D only
ANSWER: D
54.Sterilised milk lacks in
A. Vitamin A
B. Vitamin D
C. Vitamin C
D. Thiamin
E. All of the above
ANSWER: C
55.The most important natural antioxidant is
A. Vitamin D
B. Vitamin E
C. Vitamin B12
D. Vitamin K
E. All of these
ANSWER: B
56.Active coenzyme forms of vitamin B5:
A. FAD and FMN
B. Pyridoxal phosphate
C. NAD and NADP
D. Pyridoxamine
E. Coenzyme A
ANSWER: C
57.Choose physiological name of vitamin B2:
A. Antianemic
B. Antineuritic
C. Antipellagric
D. Antiscurvy
E. Growth factor
ANSWER: E
58.Early symptoms of vitamin A deficiency:
A. Muscle dystrophy
B. Lungs inflammation
C. Liver cancer
D. Xerophthalmia ("dry eyes")
E. Petechias
ANSWER: D
59.Lipid soluble vitamins are:
A. Coenzymes
B. Modulators of cell membranes
C. Regulators of secretion of digestive juices
D. Transport of substances
E. Е. Mediators of nervous system
ANSWER: B
60.Main function of bioflavonoids is:
A. Take part in metabolism of epinephrine
B. It necessary for hydroxylation of cholesterol
C. Support the elasticity of capillaries
D. Reduce the disulfide bonds to sulphhydryl bonds
E. Participation in respiratory chain
ANSWER: C
61.The disease pellagra is developed in the lack of vitamin:
A. Thiamin.
B. Riboflavin.
C. Nicotinic acid.
D. Pantothenic acid.
E. Ascorbic acid
ANSWER: C
62.The earliest symptoms of thiamin deficiency cause disorders of some system,
except:
A. Nervous.
B. Cardio-vascular
C. Respiratory
D. Muscular
E. Digestive
ANSWER: E
63.Thiamin occurs in cells mainly as its active coenzyme form:
A. NAD
B. FAD
C. NADP
D. TPP
E. CoA
ANSWER: D
64.Vitamin B6 deficiency may occur during therapy with
A. Isoniazid
B. Terramycin
C. Sulpha drugs
D. Aspirin
E. All of these
ANSWER: A
65.Vitamin K is found in
A. Green leafy plants
B. Meat
C. Fish
D. Milk
E. All of these
ANSWER: A
66.Albumin-globulin coefficient of blood plasma of healthy people compose:
A. 3,0-4,0
B. 1,0-1,5
C. 5,0-6,5
D. 8,0-10,0
E. 1,5-2,0
ANSWER: E
67.All of the following are functions of blood except
A. Transportation of oxygen and carbon dioxide
B. Regulation of body temperature
C. Synthesis of vitamins
D. Defense against infection
E. Maintenance osmotic pressure
ANSWER: C
68.Anemia resulting from iron deficiency is called :
A. Pernicious anemia
B. Hemoffhagic anemia
C. Aplastic anemia
D. Sickle cell anemia
E. Nutritional anemia
ANSWER: B
69.Antibodies are plasma proteins that are classified as:
A. Albumins
B. Globulins
C. Fibrinogen
D. All of the above
E. Prealbumins
ANSWER: B
70.Blood is composed of :
A. Plasma and red blood cells
B. Plasma and formed elements
C. Red and white blood cells
D. Red blood cells, white blood cells and platelets
E. Plasma and platelets
ANSWER: B
71.Colloid-osmotic pressure of blood is supported by:
A. Albumins
B. B1- globulins
C. C- globulins
D. D- globulins
E. E- globulins
ANSWER: A
72.Detoxification function of blood is conditioned:
A. Gas transport (CO2 and O2)
B. Transport of nutritional substances
C. Exchange of heat between tissues and blood
D. Detoxification toxic substanses by the enzymes of blood
E. Presents in blood of antibodies and by the phagocit function of leucocytes
ANSWER: D
73.Fibrinogen - is protein of blood which executes a function:
A. Transport
B. Strukture
C. Protective
D. Regulation
E. Reduce
ANSWER: C
74.Fibrinogen is a precussor of:
A. Protrombin
B. Haptoglobin
C. Fibronektin
D. Fibrin
E. Fibroin
ANSWER: D
75.Immune status of organism is provided by:
A. Leukocytes
B. Trombocytes
C. Erythrocytes
D. Hemoglobin
E. Bilirubin
ANSWER: A
76.Sources of protein in the diet are:
A. Fats, oils, butter, and margarine
B. Green pepper, cantaloupe, citrus fruits, and broccoli
C. Deep green and orange vegetables, and citrus fruits
D. Meats, fish, legumes, nuts, dairy products, and eggs.
E. Onion, carrot, oils and apples
ANSWER: D
77.The greatest concentration of antibodies is found in the fraction of the
serum.
A. Gamma globulin
B. Albumin
C. Beta globulin
D. Alpha globulin
E. Prealbumin
ANSWER: A
78.The lymphocyte that is responsible for cell-mediated immunity is the:
A. T lymphocyte
B. NK cell
C. B lymphocyte
D. None of the above
E. All of the above
ANSWER: A
79.The part of the hemoglobin molecule directly interacts with oxygen is:
A. The tertiary protein structure
B. The sodium ion
C. Globin
D. The iron ion
E. None of the above
ANSWER: D
80.The three primary types of plasma proteins are:
A. Antibodies, metallo-proteins, lipoproteins
B. Serum, fibrin, fibrinogen
C. Albumins, globulins, fibrinogen
D. Heme, iron, globin
E. None of the above
ANSWER: C
81.Vitamin K is needed for:
A. Blood clotting
B. Prevention of sickle cell anemia
C. Hemoglobin synthesis
D. Prevention of hemolysis
E. None of the above
ANSWER: A
82.What is the difference between serum and plasma?
A. Plasma contains calcium; serum does not.
B. Plasma does not have blood cells; serum does.
C. Plasma contains fibrinogen; serum does not.
D. Plasma contains albumin; serum does not.
E. Plasma contain zinc; serum does not.
ANSWER: C
83.Bile salts are produced by the
A. Stomach
B. Liver
C. Pancreas
D. Gallbladder
E. Duodenum
ANSWER: B
84.Bilirubin is produced as the result of:
A. Digestion of salts
B. Digestion of carbohydrates
C. Digestion of phospholipid
D. Digestion of hemoglobin
E. Absorbtion of carbohydrates
ANSWER: D
85.In the liver, when large amounts of acetyl-CoA are produced, some of the
acetyl-CoA is used to form
A. Pyruvic acid
B. Citric acid
C. Ketone bodies
D. Lactic acid
E. Urea
ANSWER: C
86.Polyuria can occur in
A. Diabetes mellitus
B. Diarrhoea
C. Acute glomerulonephritis
D. High fever
E. All of the above
ANSWER: A
87.Specific gravity of urine is raised in all of the following except
A. Diabetes mellitus
B. Diabetes insipidus
C. Dehydration
D. Acute glomerulonephritis
E. A and D
ANSWER: B
88.A diuresis of a healthy adult is about:
A. 1000 – 2000 ml daily
B. 500 – 1000 ml daily
C. 1000 –3000 ml daily
D. 100 – 500 ml daily
E. 3000 – 5000 ml daily
ANSWER: A
89.A pH of urine in a norm is:
A. 5,3 – 6,8
B. 3,5 – 5
C. 2,1 – 4,3
D. 1,45 – 1,85
E. 5,5 – 7,5
ANSWER: A
90.An early feature of renal disease is
A. Impairment of the capacity of the tubule to perform osmotic work
B. Decrease in maximal tubular excretory capacity
C. Decrease in filtration factor
D. Decrease in renal plasma flow
E. Both A and D
ANSWER: A
91.At what disease colour of urine is darkly – brown?
A. Pyelonephritis
B. Diabetes mellitus
C. Hemolytic anemia
D. Acute nephritis
E. Diabetes insipidus
ANSWER: C
92.Glomerular filtrate – it is a:
A. Whole blood
B. Blood plasma with a proteins
C. Blood plasma without any proteins
D. Blood plasma without glucose
E. Blood plasma without glucose and proteins
ANSWER: C
93.Haematuria can occur in all of the following except
A. Acute glomerulonephritis
B. Cancer of urinary tract
C. Stone in urinary tract
D. Mismatched blood transfusion
E. Both C and D
ANSWER: D
94.How is the increase of acidity of urine named?
A. Hyperaciduriya
B. Glucosuria
C. Ketonuria
D. Creatinuriya
E. Hyperacidity
ANSWER: A
95.How is the increase of day's diuresis named?
A. Anuria
B. Polakiuria
C. Oligouria
D. Ischuria
E. Polyuria
ANSWER: E
96.How is the increase of day's diuresis named?
A. Anuria
B. Polakiuria
C. Oligouria
D. Ischuria
E. Poliuria
ANSWER: E
97.Name the end product of protein’s metabolism, which is excreted with urine:
A. Uric acid
B. Urea
C. Indican
D. Hyaluronic acid
E. Creatinine
ANSWER: B
98.Renal threshold for glucose is:
A. 8-10 ?mol l/l
B. 35 ?mol /l
C. 8-10 mmol/l
D. 10-12 mmol/l
E. 10-12 ?mol /l
ANSWER: C
99.Structural – functional unit of kidneys is:
A. Glomerulus
B. Kidney papilla
C. Capsule of Bowmen
D. Neuron
E. Nephron
ANSWER: E
100.The pathological components of urine are all of the followings, except:
A. Ketone bodies
B. Blood
C. Amino acid
D. Bile pigments
E. Glucose
ANSWER: C