COST
Domain Committee
"Domain Individuals, Societies, Cultures and Health"
COST Action IS1002
Start Date 09-11-2010
MODERNET: A network for development of new techniques for discovering trends in occupational
and work-related diseases and tracing new and emerging risks
MONITORING
PROGRESS REPORT
Reporting Period: from 9-11-2010 to 08-11-2014
This Report is presented to the relevant Domain Committee.
It contains three parts:
I. Management Report prepared by the COST Office/Grant Holder
II. Scientific Report prepared by the Chair of the Management Committee of the Action
III. Previous versions of the Scientific Report; i.e., part II of past reporting periods
IV. Evaluation Report prepared by the “ad hoc” Evaluation Panel, established by
the Domain Committee, and edited by the COST Office.
V. DC General Assessment prepared by the Domain Committee
Appendices:
Annex 1 –Impact of networking
Annex 2 –Dissemination
Annex 3 –Workshops and Final conference abstracts
Annex 4 –WGs reports
Confidentiality: the documents will be made available to the public via the COST Action web
page except for chapter II.D. Self-evaluation and IV. DC General Assessment.
Executive summary (max.250 words):
MODERNET is a network for the development of new techniques for studying trends in
occupational and work-related diseases and for discovering new or emerging risks. The two main
drivers for the concept were: [a] The realisation that the EU did not have reliable enough means of
measuring trends in occupational disease (OD). [b] The need for the collective and early
identification of new OD and health risks. The four Working Groups in this Action therefore
addressed: 1. Quality of data collection; 2. Improving methods for the analysis of trends;
3.Developing techniques for tracing newly occurring OD, and 4. Dissemination of new knowledge
on OD.
The Action surveyed existent data sources for monitoring the frequency of OD in the EU and
developed recommendations for OD registration. It undertook a Cochrane Review on
“Interventions to increase the reporting of OD by physicians”. It analysed multinational trends in a
range of OD. It developed and applied methodology for analysing national changes in incidence of
OD as well as demonstrating the impact of national and EU level interventions to prevent OD. The
Action developed and used a tool based on a sentinel clinical system to detect new work related
diseases (OccWatch project). An interactive website was established
(http://www.costmodernet.org) as well as using scientific journals and social media for
dissemination. The network eventually comprised 17 countries and 2 institutions from non-COST
countries, and has trained 14 researchers through Short Term Scientific Missions and supported
about 65 more in its scientific workshops and conferences.
I. Management Report prepared by the COST Office/Grant Holder
I.A. COST Action Fact Sheet
 COST Action IS1002 Modernet, a network for development of new techniques for discovering trends in occupational
and work-related diseases and tracing new and emerging risks
 Domain Individuals, Societies, Cultures and Health (ICSH)
 Action details:
CSO Approval: 25/05/2010
Entry into force: 20/08/2010
End date: 08/11/2014
Extension:(day/month/year)
 Objectives
Occupational diseases (ODs) impose a heavy burden on both workers and employers and represent enormous
economic costs. In general, the information on incidence and prevalence of occupational diseases is rather poor and
inconsistent between countries, and there is an urgent need for new methods and instruments to trace new and
emerging occupational health (OH) risks. This Action’s objectives are to develop a network for exchange of knowledge
on, and setting the basis for comparative evaluation and development of new techniques to enhance the information
on trends in ODs, on discovering and validating new OH risks more quickly (data mining, workers’ and physicians’
reporting coupled with novel statistical techniques) and use of modern techniques to discuss and disseminate
information (platforms, social media).
 Parties: list of countries and date of acceptance
Belgium 30-09-2010
Bosnia and Herzegovina 05/12/2012
Croatia 04-05-2011
Czech Rep. 23-09-2010
Finland 20-08-2010
France 20-08-2010
FYR of Macedonia 22-11-2011
Germany 14-09-2010
Iceland 11-01-2011
Ireland 07-02-2011
Italy 10-09-2010
Malta 29-7-2013
Netherlands 20-08-2010
Norway 16-09-2010
Portugal 13-10-2010
Romania 20-08-2010
Spain 04-11-2010
Switzerland, 24-9-2013
United Kingdom 20-08-2010
Intentions to accept: Membership of Turkey was in principle accepted by mail by the MC members in March 2013. Membership
required approval by the National Coordinator of Turkey. Approval was denied, so Turkey does not participate in the Action.
 Other participants: Participating Institutions from Non-COST countries: Australia, Monash University; and Albania,
Institute of Public Health
Chair: Professor Raymond Agius
DC Rapporteur: Prof. Rita ZUKAUSKIENE
The University of Manchester, Centre for Occupational
& Environmental Health, M13 9PL Manchester United
Kingdom raymond.agius@manchester.ac.uk
DC Rapporteur of IS1002 ISCH
Mykolas Romeris University Ateities 20 LT08303 Vilnius Lithuania
rzukausk@mruni.eu
Science Officer: Dr Luule MIZERA,
Administrative Officer: Leo Guilfoyle,
leo.guilfoyle@cost.eu
Luule.Mizera@cost.eu
Action Web site:
http://www.costmodernet.org
Grant Holder Representative
Eugenie Quartier, e.i.quartier@amc.uva.nl
Gwendoleyn Pinas, g.h.pinas@amc.uva.nl
Annet Lenderink, a.f.lenderink@amc.uva.nl
 Working Groups (names and affiliations)
 WG 1 Quality of data
Stefano Mattioli (University of Bologna, Italy; WG leader), Dick Spreeuwers (Sanecon, Netherlands), Yogi Samant
(Labour Inspectorate, Norway), Melanie Carder (University of Manchester, UK), Antoon de Schrijver (University of
Antwerp, IDEWE, Belgium), Viorel Lefter (The Academy of Economic Studies in Bucharest, Romania), Riita Sauni
(Finnish Institute of Occupational Health, Finland), Kieran Sludds (Health and Safety Authority, Ireland), Giuseppe
Campo (INAIL, Italy), Peter Noone (HSE, Ireland), Stefan Scholz (Suva, Switzerland), Elisaveta Stikova (Institute of Public
Health, FYROM), Daniela Pelclova (Charles University in Prague, Czech Republic), Tore Tynes (National Institute of
Occupational Health, Norway), Malcolm Sim (Monash University, Melbourne Australia), Pavel Urban (National
Institute of Public Health, Czech Republic), Madeleine Valenty (INVS, France), Axel Wannag (Labour Inspectorate,
Norway), Stefania Curti (University of Bologna, Italy), Stéphanie Rivière (InVS, France), MaylisTelle-Lamberton (ANSES,
France ), Kirsi Karvala (Finish Institute of Occupational Health, Finland), Julian Mamo (University of Malta, Medical
School, Malta), David Miedinger (SUVA, Switzerland), Nurka Pranjic (University of Tuzla, Bosnia), Naum Veslievski
(Worker's Health Center Ramazzini-Strumica, FYROM), Neville Callega (University of Malta, Medical School Malta),
Mounia El-Yamani (InVS, France)
 WG 2 Trends Analysis
Roseanne McNamee (University of Manchester, UK) (WG leader), Jill Stocks (University of Manchester, UK), Teake Pal
(NCvB/Coronel Institute, AMC, University of Amsterdam, Netherlands), Christophe Paris (CHU Nancy, Nancy, France),
Stefan Gravemeyer (Deutsche Gesetzliche Unfallversicherung (DGUV), Germany), Henk van der Molen (NCvB/Coronel
Institute, AMC, University of Amsterdam, Netherlands), Lynda Bensefa-Colas (Hôpital Cochin, France), Serge Faye
(ANSES, France), Melina Lebarbier (ANSES, France), Martijn Schouteden (IDEWE, Belgium), Joseph Ngatchou-Wandii
(University of Lorraine, France), Yurika Iwatsubo (InVS, France), Sabira Smaili (InVS, France)
 WG 3 Newly occurring occupational diseases
Vincent Bonneterre (CHU Grenoble (Grenoble Teaching Hospital), France, WG leader), Dominique Bicout (CHU
Grenoble (Grenoble Teaching Hospital), France), Pierluigi Cocco (University of Cagliari, Italy), Jorge Costa-David
(European Union), Regis de Gaudemaris (CHU Grenoble (Grenoble Teaching Hospital), France), Lode Godderis
(KULeuven, IDEWE, Belgium), Begoña Martinez (University of Zaragoza, Spain), Stephan Keirsbilck (KULeuven, IDEWE,
Belgium), Nicole Palmen (RIVM, Netherlands), Consol Serra (Univeritat Pompeu Fabra, Barcelona, Spain), Erik
Tielemans (TNO, Netherlands), Hilde Cnossen (TNO, Netherlands), Catherine Buisson (INVS, France), Dirk Pallapies
(Institute for Prevention and Occupational Medicine - German Social Accident Insurance, Germany), Natasa Janev
(University of Zagreb, Croatia), Gert van der Laan (NCvB/Coronel Institute, AMC, University of Amsterdam,
Netherlands), Raymond Agius (University of Manchester, UK), Martin Seed (University of Manchester, UK)
Andrea Lastovkova (Charles University in Prague, Czech Republic), Godewina Mylle (IDEWE, Belgium), Tonje
Strömholm (Labour Inspectorate, Norway), Gerald Wanka (DGUV, Germany), Adriano Papale (INAIL, Italy), Arben
Luzati (Institute of Public Health, Albania), Delphine Rieutort (CHU Grenoble (Grenoble Teaching Hospital), France)
 WG 4 Dissemination
Claudio Colosio (University of Milan, Italy, WG leader), Annet Lenderink (NCvB/Coronel Institute, AMC, University of
Amsterdam, Netherlands), Hans Magne Gravseth (National Institute of Occupational Health, Norway), Annemarie
Money (University of Manchester, UK), Gerard Lasfargues (ANSES, France), Ari Kaukiainen (LocalTapiola General
Mutual Insurance Company, Finland), Jadranka Mustajbegovic (University of Zagreb, Croatia), Stefan Mandic-Rajcevic
(University of Milan, Italy), Ecaterina Gica (The Academy of Economic Studies in Bucharest, Romania), Louise Hussey
(University of Manchester, UK), Elena Bottoli (University of Bologna, Italy)
I.B. Management Committee member list
Name
Prof. Arben Luzati
Prof. Malcolm Sim
Prof.Antoon de Schryver
Prof Lode Godderis
Dr. Sofie Vandenbroeck
Dr. Nurka Pranjic
Prof.Jadranka Mustajbegovic
Ms.Natasa Janev
Dr.Pavel Urban
Dr.Zbynek Bittner
Dr.Riita Sauni
Dr.Ari Kaukianinen
Dr.Kirsi Karvala
Prof.Elisaveta Stikova
Dr. Naum VESLIEVSKI
Dr Vincent Bonneterre
Dr Maylis Telle-Lamberton
Prof Regis de Gaudemaris
Dr Dirk Pallapies
Dr.Stefan Gravemeyer
Mr.Gerald Wanka
Prof.Thomas Bruening
Ms Asta Snorradottir
Mr.Kieran Sludds
Dr. Peter Noone
Dr.Claudio Colosio
Prof.Stefano Mattioli
Dr. Neville Callega
Dr. Julian Mamo
Dr Gert van der Laan
Dr Annet Lenderink
Dr.Henk van der Molen
Dr.Yogi Samant
Dr.Hans Magne Gravseth
Dr.Axel Wannag
Dr. Tonje Stromholm
Vacancy*
Prof.Viorel Lefter
Ms Viorica Petreanu
Dr Ecaterina Gica
Prof. Begoña Martinez Jarreta
Prof. Consol Serra Pujadas
Dr Rafael Pinilla Pallejà
Dr David MIEDINGER
Dr Stefan SCHOLZ
Prof. Roseanne McNamee
Prof. Raymond AGIUS
Dr. Jill Stocks
Country
E-mail
Albania (non-COST)
Australia (non-COST)
Belgium
Belgium
Belgium (sub)
Bosnia and Herzegovina
Croatia
Croatia (sub)
Czech Republic
Czech Republic
Finland
Finland
Finland (sub)
Former Yugoslav Republic
of Macedonia
Former Yugoslav Republic
of Macedonia (sub)
France
France
France (sub)
Germany
Germany
Germany (sub)
Germany (sub)
Iceland
Ireland
Ireland
Italy
Italy
Malta
Malta
Netherlands
Netherlands
Netherlands (sub)
Norway
Norway
Norway (sub)
Norway (sub)
Portugal
Romania
Romania
Romania (sub)
Spain
Spain
Spain (sub)
Switzerland
Switzerland
United Kingdom
United Kingdom
United Kingdom
arbenluzati@gmail.com
Malcolm.Sim@med.monash.edu.au
Antoon.deschryver@ua.ac.be
Lode.godderis@med.kuleuven.be
Sofie.vandenbroeck@idewe.be
pranicnurka@hotmail.com
Jadranka.mustajbegovic@snz.hr
Natasa.janev@snz.hr
Pavel.urban@szu.cz
Zbynek.bittner@seznam.cz
Riitta.sauni@ttl.fi
Ari.Kaukiainen@lahitapiola.fi
Kirsi.karvala@ttl.fi
estikova@ukim.edu.mk
naum.veslievski@gmail.com
vbonneterre@chu-grenoble.fr
maylis.lamb@free.fr
RDeGaudemaris@chu-grenoble.fr
pallapies@ipa-dguv.de
stefan.gravemeyer@dguv.de
Gerald.wanka@dguv.de
bruening@ipa-dguv.de
asta@ver.is
kieran_sludds@hsa.ie
noone.p@hse.ie
claudio.colosio@unimi.it
s.mattioli@unibo.it
neville.calleja@um.edu.mt
julian.mamo@um.edu.mt
g.vanderlaan@amc.uva.nl
a.f.lenderink@amc.uva.nl
h.f.vandermolen@amc.uva.nl
Yogindra.samant@arbeidstilsynet.no
hmg@stami.no
axel.wannag@arbeidstilsynet.no
tonje.stromholm@arbeidstilsynet.no
* left after one meeting
vlefter@ase.ro
vioricapetreanu@yahoo.com
ecaterina.gica@yahoo.com
mjarreta@unizar.es
CSerraPujadas@parcdesalutmar.cat
rpinilla@betqol.com
david.miedinger@suva.ch
stefan.scholz@suva.ch
Roseanne.Mcnamee@manchester.ac.uk
Raymond.Agius@manchester.ac.uk
Jill.Stocks@manchester.ac.uk
I.C. Overview activities and expenditure 1 April 2014 to 14 October 2014
Total Action Budget: € 407.135,00
Year 1 (€)
Year 2 (€)
Year 3 (€)
Year (4)
Total (€)
Grant Budget
70.000,00
96.570,00
111.565,00
129.000,00
407.135,00
Science Expenditure
40.523,66
72.546,36
83.620,61
110.519,90
307.210,53
35.630,99
66.463,36
75.450,61
101.816,90
279.361,86

Meetings

STSMs
0,00
4.500,00
6.660,00
7.100,00
18.260,00

Training school
0,00
0,00
0,00
0,00
0,00

Dissemination
4.892,67
1.583,00
1.502,00
1603,00
9.580,67

OERSA
0,00
0,00
0,00
0,00
0,00
Management
6.078,22
9.797,34
12.259,49
16.578,00
44.713,05
Total eligible
46.601,88
82.343,70
95.880,10
127.097,90
351.923,58
Meetings
COST (€)
Total (€)
Type of meeting
Place
Dates
P (TR)
MC + WGs
Amsterdam
6 April 2011
44 (27)
14.320,51
MC + WGs
Manchester
17-18 Nov. 2011
51 (24)
21.310,48
WG1 (Cochrane)
Paris
13-15 Feb. 2012
7 (6)
3.224,83
MC + WGs
Leuven
12-14 June 2012
61(41)
31.668,05
MC + WGs
Rome
7-9 Nov. 2012
57(40)
31.570,48
WG1 (Cochrane)
Tampere
5-7 Feb. 2013
8(5)
3.590,57
MC + WGs
Bucharest
29-31 May 2013
64(48)
41.434,59
MC + WGs
Paris
16-18 Oct. 2013
76(39)
30.425,45
MC + WGs
Zaragoza
8-11 April 2013
68(50)
46.107,08
WGs (Signal detection)
Paris
17-7-2014
13(4)
943,80
Final Action meeting
Bologna
13-14 Oct. 2014
77(73)
54.765,90
STSM
Cost (€)
Beneficiary
Date
Place
Dr. Andrea Zavadilova
14-21 June 2012
Manchester
1000,00
Mrs. Annet Lenderink
1-5 Oct. 2012
Trondheim/Oslo
1000,00
Dr. Vincent Bonneterre
1 Oct. – 30 Nov. 2012
Manchester
2500,00
Dr. Nataša Janev-Holcer
4-8 March 2013
Helsinki
1200,00
Dr. Stefania Curti
1-14 Sep. 2013
Manchester
1600,00
Dr. Stefan Mandic-Rajcevic
19-26 Oct. 2013
Grenoble
1100,00
Dr. Lynda Bensefa-Colas
21-30 Oct. 2013
Manchester
1400,00
Dr. Gaia Varischi
4-10 Nov. 2013
Amsterdam
1360,00
Dr. Jill Stocks
19-26 May 2014
Paris
1000,00
Dr. Madeleine Valenty
2-6 June 2014
Manchester
800,00
Dr. Yuriko Iwatsubo
2-6 June 2014
Manchester
800,00
Ms. Sabira Smaili
2-20 June 2014
Manchester
2400,00
Total (€)
Begoña Martinez-Jarreta
19-26 Aug. 2014
Manchester
1000,00
Martijn Schouteden
29 Sep.- 3 Oct. 2014
Grenoble
1100,00
Dissemination
COST (€)
Total (€)
Title
Date
Organization
Web development and maintenance
2011
NCOD/AMC
4.892,67
Website maintenance
2012
NCOD/AMC
1.502,00
Posters (2, printing)
2012
Univ. of Manchester
Website maintenance
2013
NCOD/AMC
1510,00
Website maintenance
2014
NCOD/AMC
1548,00
Modernet Poster printing
2014
Univ. of Manchester
81,00
55,00
Administration and coordination (FSAC)
COST (€)
Date
From
To
Administrative and financial support AMC
1-12-2010
30-11-2011
6.078,22
Administrative and financial support AMC
1-12-2011
30-11-2012
9.797,34
Administrative and financial support AMC
1-12-2012
30-11-2013
12.259,49
Administrative and financial support AMC
1-12-2013
08-11-2014
16.578,00
Total (€)
II. Scientific Report
II.A Innovative networking
COST Modernet’s position in the EU environment
The first achievement in the 'process' of the network was in setting up, for the first time in
the EU, a collaborative network of researchers in the areas of measuring temporal trends
in occupational diseases (ODs) and in detecting new and emerging occupational health
risks.
In terms of a collective conclusion by the network of the needs within the EU, it was
deemed essential for all stakeholders including policy makers, occupational health
professionals as well as employees, employers and the public to have reliable information
on the trends in incidence of work related disease so as to be better able to intervene and
achieve reductions in risk through legislation, enforcement and education. The network
also concluded that interventions ought also to be evaluated using corresponding reliable
measurements of incidence. The challenges that hinder such reliable measurements had
prompted EUROSTAT to effectively stop prioritising and to curtail publication of data on
occupational disease (OD) frequency in the member states. Nevertheless, as outlined
hereunder the innovative networking of this COST Action permitted it to successfully
achieve these important needs. Therefore, while the current EUROSTAT position is that
the diversity of data systems makes it hard to compare incidence across countries, our
group has reached the conclusion that comparisons of temporal trends is possible from
these systems. Furthermore, these comparisons offer the opportunity to evaluate the
impact of policy interventions – at EU or national level - on workers’ health.
The network recognised the equally important necessity to identify rarer or newer OD and
work related health risks. It is heartening to note that the European Agency for Safety and
Health at Work has also perceived the same need (as exemplified by its recent publication
of a "Scoping study for a foresight on new and emerging occupational safety and health
(OSH) risks and challenges"). Moreover the work of the Action is complementary to that of
the European Agency as the network addressed the need (as yet unmet in the EU) to have
collective international sentinel reporting schemes to trace novel diseases or discover new
circumstances of exposure leading to disease. Looking to the future the innovative
networking of the Action realises that the biggest challenge relates to ‘ideal prevention’
which would require the capacity to predict, and thence pre-empt, hazards to health even
before they become manifest as disease in workers.
In this report a more detailed description of the achievements of the innovative networking
is given in the sections below dealing with each of the four Working Groups respectively.
However the paragraphs below summarise shared principles and outlooks.
COST Modernet’s innovative activities
Firstly Modernet, resourced by the EU COST Action funding, established a baseline of the
knowledge of the type and quality of relevant extant information amongst the participating
states. Then it developed, disseminated and eventually applied scientific methods in
several domains for measuring trends, evaluating interventions, and detecting risks
amongst the member states. Part of the innovation consisted of the search, testing, and
assessment of the relevance for Modernet objectives of the methods used in other
scientific fields. These include methods for policy evaluation as used in social sciences
and methods for detecting new risks.
From innovation to practice
These methods have been put into practice: for example 10 countries collaborated, for the
first time, in sharing data from their national systems to evaluate and compare trends in
work-related disease in the EU from 2000 to 2012. Our published methods evaluating
interventions to prevent WRDs were initially developed in one country but as a result of the
network they are being applied collaboratively - with corroborated findings in other EU
states
From practice in innovative networking to dissemination
Subjectively it was a pleasure to see members greet each other at meetings, to experience
a common 'buzz' at what was being achieved and to carry on this interaction through
social media and other electronic means in between the face to face meetings. The more
difficult task was to extend this to the wider community. As described in more detail in the
report of WG4, the network has not only used the conventional peer-reviewed but
relatively passive means of dissemination but it has gone on to adopt a wide range of
modern media to achieve dissemination and two way interaction with its stakeholders.
Modernet’s legacy and future funding opportunities
Modernet started as a network about 4 years before the award of funding for the COST
Action. It is carrying on beyond the conclusion of COST support. Various research
collaborations (some funded by national sources) are continuing as are the means of
dissemination. Some aspects of the activity of the network have formed the basis of an
application to Horizon 2020 (“ANTICIPATE” – Anticipation and Prevention of Occupational
and Environmental Health Issues in EU citizens) although the outcome of this application
is still awaited.
II.B. Inter-disciplinary networking
Nature of inter-disciplinarity
One of the main accomplishments and assets of COST Modernet has been its interdisciplinarily. It generated a very collegial and integrated platform for intellectual
exchanges between all its members of different disciplines and experience. This built trust
as well as mutual understanding and respect for the perspectives and varied potential
contributions of all its members many of whom had not known each other before this
COST Action. The output of the network has relied on close multidimensional working
between occupational physicians, occupational hygienists, safety engineers, toxicologists,
epidemiologists and statisticians and other disciplines. The interactions were dynamic and
changing for example with migrations and cross-fertilisations of ideas between the various
groupings. They enabled common needs to be agreed by collective negotiation, and
concepts to be tested challenged and to evolve.
How inter-disciplinarity has been put into practice
A good example of this is how the quality criteria determined by Working Group 1 (WG1)
addressed various issues from medical ones of diagnosis and attribution to statistical
ones. The work WG1 on quality of data relied on close working between physicians,
epidemiologists and statisticians amongst others. Thus the quality criteria determined by
this WG addressed various issues from medical ones of diagnosis and attribution to
statistical ones, and hence in turn underpinned the work of the other WGs. In this manner
WG1 proposed ideas on how to specify the “ideal” register of data regarding ODs, how to
promote and perform evaluation of effectiveness of interventions to increase OD reporting
(new laws or surveillance systems), and how to prepare search-strings to explore the
literature regarding occupational aetiology of diseases (a useful tool to execute systematic
reviews in the field of aetiology of ODs).
Correspondingly Working Group 2 (WG2) dealing with national trends in WRDs and
methods for evaluating interventions, was led by statisticians and epidemiologists, but also
included physicians and other occupational health specialists closely involved in
‘generating’ the data (i.e. diagnoses, and ancillary demographic and occupational ‘fields’)
or managing data systems. In the collection of data, this inter-disciplinarity was also
manifest with sources from a wide range of agencies – some closely linked with insurance
schemes, others linked to national health care provision, while other schemes were totally
voluntary.
In detecting new hazards, besides medical and toxicology expertise, epidemiology,
computer science and occupational hygiene within MODERNET, networking with other
groups was especially valuable in Working Group 3 (WG3). Thus WG3 welcomed experts
with skills in text mining from the TNO institute (NL) who had previously developed an
Emerging Risk Identification Support Service in the field of food safety. The experience of
EFSA and their Emrisk unit, dedicated to the detection and expertise of new risks related
to food, was also a source of inspiration, as well as other vigilance methods (e.g.
pharmacovigilance). Other output relied on collaboration with experts in Geographic
Information Systems (GIS) or in Quantitative Structure Activity Relationships – important
tools in identifying or predicting new OD hazards.
Close links with national institutions in charge of health and safety was also essential,
notably with ANSES in France which continues to offer a support for the Modernet
OccWatch project offering the opportunity for clinicians to share detailed information about
cases thought to be sentinel of new ODs/WRDs.
Another example of collaborative work between the working groups is the work of WG1
and WG3 on the issue of the “convincing evidence” that has to be reached to conclude
that a certain disease, in specified occupational exposure conditions, could be considered
work-related. Such judgements are based on interdisciplinary discussions between experts
ranging from physicians to statisticians.
The whole Action worked very coherently both in achieving the above goals and in their
final dissemination through Working Group 4. An incipient special issue of the peerreviewed journal “Occupational Medicine” will tangibly demonstrate both the outputs
mentioned in the previous section, and the inter-disciplinarity addressed in this section. It
is anticipated that the authoritative findings, validated methods and generalisable
recommendations that will result should therefore besides scientific impacts, also have
socio-economic impacts. These impacts are particularly relevant for policy makers wishing
to determine the burden of ODs, the value of interventions, and the likely emergent
threats.
II.C. New networking
Participants
During the life of the Action from its first launch in November 2010 about sixty additional
new members joined. The total number of individual participants involved in the Action
work was about 70 at any one time. Of the current 85, there are 36 females (42%) and 25
(29%) Early Stage Researcher (ESR) participants
ESR and training
Early Stage Researchers (ESRs) continue to be intimately involved both in the processes
such as networking activities, and in the output including presentations at COST Modernet
meetings as well as at other conferences such as the EU meeting on Occupational
Diseases in Brussels in 2013. A number of STSM participants (an overview at the end of
this report) including ESRs took datasets with them to analyse with the help of staff and
methods in the host centre – thus fostering new collaborations which are being translated
into scientific publications. Moreover the biannual Action conferences and workshops
strongly encouraged and featured presentations by the ESRs guided by their mentors.
Therefore in spite of the fact that the budget precluded the organisation of a Training
School as such, extensive and very customised and detailed practical training was given to
the ESRs.
COST Modernet website
The comprehensive project website with user-interactive functions which was set up early
in the COST Action has continued to grow: http://www.costmodernet.org/
The website informs both participants and the wider public about the aims, structure,
composition and outputs of the project. It also continues to provide a secure forum for
online information sharing, communication and debate between the MODERNET
consortium network members. Among other useful information, summaries of STSM can
be found there. It is also worth mentioning that the Consortium is actively present in the
most important social networks (LinkedIn, Facebook, Twitter, and Research Gate). Plans
have been made to continue these activities as far as possible as a legacy of this COST
Action.
Over the last year two Management Committee meetings combined with conferences /
workshops have been undertaken (Paris - October 2013, and Zaragoza April 2014) and
the third meeting will be the final Action meeting on 13-14 October 2014 in Bologna (Italy),
back to back with the yearly Congress of the Italian Society of Occupational Health and
Safety (SIMLII) and a meeting of two Scientific Committees of the International
Commission on Occupational health (ICOH) on Occupational Health Surveillance (15-16
October 2012).
The meetings already conducted, have resulted in tangible interdisciplinary work towards
this Cost Action’s dissemination of its scientific results programme in the peer reviewed
literature, and the forthcoming one is being developed in the same line. The activities of
passive dissemination conducted by the Consortium will culminate in the publication of a
special edition of the peer-reviewed journal ‘Occupational Medicine’: Ten publications have
been prompted by the Action so far, with a further 14 anticipated in the special edition, and
more than other 20 elsewhere. However besides these network-specific publications, more
than a further hundred works relevant to the Action’s objectives of identifying new OD or
measuring trends in OD incidence have been published by MODERNET members. The list
of publications and other outreach activities that resulted from COST networking through
the Action is given in the Annex).
This COST Action was either an essential feature (as in the Cochrane project, or the
Occwatch sentinel clinical system) or an adjuvant asset in members raising research
funds; such as €1.8M from UK and IE governmental agencies for measuring trends in OD
in those countries. A mentioned there was also collaboration with various national
agencies especially the French Institution (ANSES) supporting the national network for
work related disease vigilance and prevention (RNV3P).
Networking with other groups
At a more strategic level networking links have been forged with another COST Action:
ISCH COST Action TD1206 Standerm, whose Chair (Professor Swen John) has been
invited to address our final COST Action meeting in Bologna in October 2014, as well as
with public health colleagues with whose wider environmental remit there is a common
interface. Similarly contacts were made with the US AOEC (Association of Occupational &
Environmental Clinics) in order to launch collaborations regarding new Work Related
Diseases.
II.D. Self-evaluation
The consensus of opinion of the management committee (MC) is that the main successes
of the Action were:
•
•
•
•
•
The establishment of a very collegial international and inter-disciplinary network
which included Early Stage Researchers as peers, fostered their enthusiasm
and supported their training needs within the common purposes mentioned
below:
The development of recommendations on the best means of motivating physicians
and others to recognise and report OD, suitable means of data collection, taking
account of national feasibility, and the standards of the quality of data essential
to measure and track trends in the burden of occupational disease in the EU
The sharing and application of methodology to estimate the true temporal trends in
the reported incidence of occupational diseases (OD) in Europe, as well as the
development and application of methods to evaluate national or EU level
interventions aimed at reducing the risks of OD
The development and international application of methods to identify new ‘signals’
of emerging work related diseases and to help predict new hazards. Most
notable is the launch of a European sentinel clinical watch system (OccWatch
project), designed to capture case-reports of potentially new work related
diseases, to look for similar cases in other countries, to ensure a common
expertise was applied to the cases, and finally to disseminate information to
stakeholders when relevant for preventive purposes.
The utilisation of a variety of methods (from peer review literature to the Web, and
social media) for the continuing dissemination of the above.
Arguably a drawback of the COST Action has remained the effort and time involved in the
work, especially with Universities often place emphasis on primary hypothesis driven fully
externally funded research. Nevertheless we still believe that this COST Action has been
an invaluable collaborative opportunity acting as a stepping stone to further international
and interdisciplinary collaborations with scientific as well as socio-economic impact.
One hopeful expectation had been that the Horizon 2020 document in the year preceding
the December 2013 identified the following EU needs of “… improving surveillance and
preparedness…. &… improving scientific tools and methods to support policy making and
regulatory needs ….” which mapped out remarkably well with the agenda, activity and
output of the MODERNET COST Action. However since these terms were no longer
featured in the official H2020 call of December 2013, the scope of the application of a
number of the Modernet partners to H2020 does not cover the whole of the Modernet
agenda.
WG1: quality in data collection
Leader: 2011, Dick Spreeuwers; 2012-2014, Stefano Mattioli
Since the first meeting of the COST Action-Modernet, Working Group 1 (WG1) was
established with the aim of promoting the quality of the data collected regarding
occupational diseases in the different EU Countries,.
In 2012 our aims were reformulated as follows:
1. To evaluate the effect of interventions aimed at increasing the reporting of
occupational diseases through a Cochrane review (substituting the originally
proposed Delphi study)
2. To study the differences in the classification systems of occupational diseases used
in different European countries
3. To increase quality in the collection of literature data on occupational diseases,
promoting the use of efficient search strings
4. To define the level of evidence needed to scientifically define a disease as a new
work-related disease
5. To study the nomenclature utilised in the different databases of occupational
diseases
Regarding the goals that the WG1 had to achieve, on the quality of work-related diseases
data, we obtained valuable results, during the fruitful meetings held during these years.
Result 1
A Cochrane review on interventions to increase the reporting of occupational diseases,
whose Protocol won an award as the best 2012 proposal, is in its final step, after the last
review. Seven members of our WG1, coming from 5 different countries, contributed to the
Cochrane review, demonstrating the usefulness of the meetings (and of two extrameetings) that permitted us to work together effectively and efficiently.
The review showed that we need interventions to increase the number of notified
occupational diseases and that the effectiveness of some interventions (e.g. new
surveillance systems) has yet to be studied.
Result 2 (aim 2 + aim 5)
Some other members of our WG1, cooperating with colleagues of WG2, explored the way
in which the European Countries classify work-related diseases, also identifying the
different nomenclatures adopted. This survey demonstrated differences and shortcomings
of the various European systems, providing conclusions regarding the “ideal” data-base in
the field of occupational diseases. The results of this experience were used to prepare a
paper, since submitted for publication.
Result 3
A way of preparing search-strings to explore the literature has been obtained from the
experience of the last published paper on the strategies for detecting articles on
agricultural workers’ diseases. Researches on occupational origin of disease could be
facilitated by the use of such kind of tools.
Result 4a
The concept of “occupational diseases” versus “work-related health problems” has been
debated in a report produced by a WG1 sub-group, posing the basis for a paper to be
published on a scientific journal.
Result 4b
In collaboration with colleagues of WG3, a WG1 sub-group worked on a review of the
articles reporting proposals on the issue of the “convincing evidence” that has to be
reached to say that a specific disease, in certain occupational exposure conditions, could
be considered work-related. After having planned the search strategies, we retrieved
information from the literature and presented the results during the final meeting in
Bologna. This issue will be useful also in the next future, considering the increased
relevance of correctly executed aetiological reviews concerning diseases of putative
occupational origin.
STSMs
One member of WG1 executed an STSM, to exchange and learn about methods to permit
an increase in the number of occupational diseases notified by general practitioners.
Broader achievements
The MODERNET WG1 collaboration has led to:
Increased understanding of the relevance of interventions aimed to increase the reporting
of occupational diseases;
Increased understanding of strengths and differences in surveillance systems in Europe;
Dissemination of efficient search strings to retrieve papers on occupational diseases;
Increased understanding of the importance to execute - correctly – systematic reviews on
occupational aetiology of diseases.
We believe that our work on data quality directly contributes to the key strategic objective
of the EU Strategic Framework on Health and Safety at Work 2014-2020 to improve
statistical data collection and analysis. Moreover, it contributes to facilitate the evidencebased evaluation of occupational origin of diseases
WG2: application of new techniques and methods for analysis of trends in
occupational diseases
Leaders: R McNamee, J Stocks
In 2010, WG2 consisted of members from only three countries which collected data on
incident cases of work-related diseases, including occupational diseases, diagnosed by
physicians. It became clear that there was a great diversity of methodologies for collection
of data within these purpose-built surveillance schemes. By the end of the Action, there
were participants from 10 European countries revealing further diversification of methods.
The 2013 EU report on the current situation in relation to occupational diseases’ systems
in EU Member States noted that “The diversity …makes it hard to compare the statistics
between countries”. An initial but ongoing task for WG2 was therefore to clarify whether
any valid international comparisons could be made. Our argument, presented at the EU
conference in Brussels in December 2013 and reinforced in our publications, is that while
the diversity of approaches to surveillance might invalidate comparisons of absolute
incidence, this would not necessarily be a problem for comparisons of within-country
change in incidence, i.e. ‘time trends’.
Our first methodological goal thereafter was to describe how best to estimate temporal
trends in true incidence of Work-Related Disease in each country from surveillance data.
The critical issue is temporal biases – either structural changes in the surveillance scheme
or external factors such as changes in awareness -which could lead to artefactual changes
in the number of cases captured by surveillance schemes. To be valid, any statistical
analysis of ‘trends’ would need to account for these biases. Our discussions revealed that
the nature of these biases also varied between countries. Nevertheless we agreed on a
flexible form of statistical analysis, carried out separately for each country and taking
account of local factors. Our second goal, related to the first, was to implement this
methodology to compare temporal trends in as many EU countries as is feasible.
Results 1: Both agreed methods and application are described in our paper (Stocks,
McNamee al. Trends in incidence of occupational diseases in 10 European Countries
2000-2012, accepted for publication by Occupational and Environmental Medicine, Dec
2014). We believe that this is the first such comparison of time trends in work-related
diseases between European countries
As explained by WHO, surveillance schemes should also allow evaluation of the impact of
public health interventions, including the impact on incidence of work-related diseases of
legislative interventions to control exposures at national or EU level, to control exposures.
The third and fourth objectives of WG2, outlined in our application were to show how one
might evaluate the impact of such interventions using data from occupational surveillance
schemes using three ‘case studies’.
For a comparison of incidence ‘before and after’ an intervention to be valid, surveillance
scheme data should be free from temporal bias. As this cannot be guaranteed, we
proposed a better design comparing ‘before and after’ change for the targeted disease(s)
and for a control disease from the same surveillance scheme. We implemented this design
in several studies.
Results 2: During the course of the COST action, this design was implemented to
evaluate 10 interventions in the UK (see Stocks et al, Turner et al). A collaboration
between France and UK developed during the Action has resulted in a publication led by
Bensefa-Colas, submitted in December 2014 to Occupational and Environmental
Medicine: "Effectiveness of preventative actions on occupational dermatitis to chromate in
cement in France: comparison with UK.".
STSMs: Four visits were made to exchange and learn about methods for trends estimation
and intervention evaluation in different countries
Broader achievements
The MODERNET WG2 collaboration has led to:
Increased understanding of strengths and differences in surveillance systems in Europe
Increased understanding of potential biases (for trends) and how they might be dealt with
Dissemination of ‘best’ practice in analysing trends and interventions
Renewed enthusiasm for collection of European statistics
We believe that our work on trends directly contributes to the key strategic objective of the
EU Strategic Framework on Health and Safety at Work 2014-2020 to improve statistical
data collection and analysis. Our work on evaluation of legislative interventions can also
inform national and EU policy both now, and in the future by showing how best to do this.
WG3: “New techniques for tracing newly occurring work-related diseases”
Leader: Vincent Bonneterre
Context
It is a societal challenge to detect early New Work-Related Diseases (WRD) in order to
take appropriate actions in due time. If efforts have already been made to identify
potential “drivers” of new occupational risks (Emerging Risk Observatory relying on
expert focus set up EU-OSHA), occupational health surveillance, relying on medical
data, is currently not adapted to this purpose, as most of the surveillance systems are
dedicated to monitor already well characterized occupational diseases. Regarding the
detection of new issues, the occupational health field is showing an important delay
contrarily to other medical fields already covered by vigilance systems (toxicovigilance,
pharmacovigilance, nutrivigilance in some countries, …). Convinced that a strong and
structured cooperation between EU centres specialized in WRD clinical and research
activities could strongly intensify their ability to detect early newly occurring WRD,
investigate, disseminate and monitor them, we dedicated one Modernet WG to this
topic with the following specific identified aims.
Aims
1. Exchange of information on possible newly occurring occupational diseases
(sharing of clinical cases)
2. Development of a defined procedure for signal tracing and follow up
3. Explore quantitative methods for signal tracing and refine them
4. Progress on alert systems
Result 1 (aims 1)
First of all, we proposed a common definition of what has to be considered as new
work-related diseases. Briefly, we defined them as either “new couples” between a
disease and an occupational agent, or as “new triads” “disease x agent x circumstance
of exposure” (which means a disease already reported to an agent, but occurring in a
new occupational context). We built a common template in order to share our cases
within a structured way, and many case-reports / new issues were shared and discuss
at the different meetings (cf minutes).
Result 2 (aims 2 & 4)
Initiatives have been developed at national level by Modernet partners for capturing
potentially new WRD (ex: French RNV3P approach for detection and investigation of
new WRD, NL and Be SIGNAAL tool). An alert system (graded actions according to an
algorithm) has been created at French level, and is now operational from 2014 (cf
RNV3P scientific report 2014, available on ANSES website).
We also developed a common web-tool to share the case-reports related to new issues
at trans-national EU level (currently within Modernet partners). This sentinel clinical
watch system is named « OccWatch » (for Occupational Watch), available (secured) at
https://occwatch.anses.fr/. Its aim is to 1) Capture case-reports of potentially new
WRD, 2) Gather comments of experts on each case [challenge diagnosis, exposure,
work-relatedness, hypotheses on causative agents, physiopathology and prevention
issues], seek similar cases in the different databases (French RNV3P, UK THOR, NL
NCOV, Italian Malprof, Belgian Precube, etc. ) in order to analyse the relevance of
clinical signals, 3) Produce a common expertise (conclusion and summary of
discussions), 4) Realize a briefing note, regarding medical data but also including first
information on risk assessment (population potentially exposed, severity), and
proposals for actions to be taken if necessary. Later on, the goal of this briefing note
could be to share the information with institutions concerned: national agencies, EUOSHA. This tool has been successfully tested for the 3 first steps.
Result 3
First of all, Data mining tools already used in pharmacovigilance (disproportionality
metrics), have been validated on French RNV3P database and it has been decided to
use them on a routine basis there. They have also been tested on UK THOR data,
showing an interest on these data also (cf extensive STSM report of V Bonneterre on
MODERNET website). One of their limitations is that these methods consider
occupational exposures separately.
For that reason, other methods have been developed (« Exposome » and
« Observational surveillance »), taking into consideration “multi-exposure” (as recorded
into existing databases). These methods have been presented within Modernet
sessions, and also been the subject of STSMs.
Several teams also assessed the interest of GIS (Geographical Information Systems)
in order to combine and analyse occupational health data for surveillance purposes.
One common article is to be submitted, highlighting their interest from “macro” level
(different scales, the biggest one currently being the state’s one) to the micro one
(within companies).
Finally, the Manchester team presented to other partners the value of QSARs for
highlighting Occupational Asthmagens, and conversely, the usefulness of clinical data
to improve QSARs
STSMs
3 STSMs were conducted to help achieve WG3 aims: Stefan Mandic from Milano
(2013) as well as Martin Schouteden from Leuven (2014) went one week in Grenoble
in order to study methods develop their for detecting new emerging issues. Vincent
Bonneterre went 3 months in Manchester (2 months as STSM; 2012) in order to test
disproportionality metrics on UK THOR database, and learn more about as well as
apply QSARs developed by the Manchester team.
Broader achievements
The MODERNET WG3 collaboration has led to:
-
Increase awareness of EU stakeholders of the interest and potential of “alert
systems” relying on medical data (“disease-first approach”) to detect early new
WRD. Especially because we disseminated our achievements not only in scientific
congresses (such as EPICOH Utrecht 2013), but also through EU institution, as for
example at the OccDis conference in Brussels Dec 2013, organised by DG
employment from the EU Commission, or the workshop organised by EU-OSHA in
Oct 2014 in Brussels.
-
A proposal for an integrated system of occupational health vigilance inspired from
what is done in Food Safety (EFSA)
WG4: dissemination and implementation of new knowledge on occupational
diseases
Leader: Claudio Colosio
Dissemination of the results of the project has been achieved by several passive and
active means
Methods
The first very important project outcome in the field of active dissemination has been the
creation of a project website, at the address: http://www.costmodernet.org/
In the website, two main areas have been created. The first is restricted to the Consortium
members for internal users. The second is open to the public to promote the access of a
significant number of public and private sector experts, occupational health personnel and
stakeholders to the most relevant information regarding the project and its activities as well
as to the updated information regarding techniques and practical experiences carried out
in the field of research and detection of new and emerging occupational risks and
diseases. This project website has been also a unique tool in promoting networking,
bridging among different institutions, finding partners for projects as well as for public
debates and ‘round tables’.
The website has been such an important and successful experience that it has been
decided to maintain it active after the end of the COST action, under the responsibility of
the action members.
It is worth underlining that, before the creation of the project’s website and the subsequent
opening of the request of registration, this potential large network, strongly linked with
timely and urgent EU priorities, did not exist at all. Their registration and the website visits
suggest that, around the “first circle” of active subjects (mainly MODERNET consortium
members), there is also a larger “second circle” of people interested in the topic and willing
to continuously collect updated information on trends of occupational diseases and new
and emerging risks and diseases in the European Union.
A second component of active dissemination has been the use of new internet techniques
in the enhancement of a rapid exchange of research knowledge and collaboration in
research projects through the use of social media. In fact, the Consortium is currently
actively present in the most important social networks (Linkedin, Facebook, Twitter, and
Research Gate).
Active dissemination has been carried out also through the delivery by senior Action
members of specific outreach activities about MODERNET. Such activities have been
carried out for non-members of the Action in various countries in particular by the
Chairman in Barcelona - November 2012, Rome - November 2012, Bucharest - May 2013,
Paris -October 2013.
A more passive dissemination has been carried out through the publication on peer review
journals of papers addressing the main aims and objectives of Modernet, for example as a
follow up to reported cases of occupational disease developed, delivered and evaluated by
Action members (references in added literature list).
To make the results of the Action manageable for the practice of prevention, the
development of scenarios for monitoring occupational diseases on several levels is
necessary. Verma et al. (2002)1 stated that the development of control strategies for
occupational hazards takes place at the societal and the local workplace level. These two
levels have differing information needs. At the societal level, control measures are usually
through regulatory actions on the national level or the industrial sector level. Information is
then needed on possible exposure-effect relationships as well as on workplace
demographics. At the local workplace level, information is needed on the nature of the
hazard, where it is likely to be encountered and the available options for risk reduction.
Development of scenarios on three levels is necessary: a national scenario, a scenario for
branch or sector approaches, and a scenario for the company level. The basic idea is that
monitoring should be linked to preventive measures.
The experiences of passive dissemination of the Consortium will culminate in the
realization of two collated sets of publications (besides various individual peer-reviewed
articles):
The first, will be a special issue of the peer-reviewed journal “Occupational Medicine”
which will tangibly demonstrate both the outputs mentioned in the previous section, and
the interdisciplinarity addressed in this section, and mentioned in the Chair’s contribution
above.
1
Verma DK, Purdham JT, Roels HA. Translating evidence about occupational conditions into strategies for prevention
Occup Environ Med. 2002 Mar;59(3):205-13; quiz 214.
The second will be the publication of a volume addressed at the main activities and
objectives of the network, to realize in the frame of the activities supported by the COST
office. It is anticipated that the authoritative findings, validated methods and generalisable
recommendations that will result should therefore besides scientific impacts, also have
socio-economic impacts – for policy makers wishing to determine the burden of OD, the
value of interventions, and the likely emergent threats.
STSMs in the COST Action “MODERNET”
Short-Term Scientific Missions aim at strengthening the Modernet COST Action by
allowing scientists to go to an institution in another COST country to foster collaboration or
to learn new techniques (e.g. trend analysis, GIS,…) for discovering trends in occupational
and work-related diseases and tracing new and emerging risks. In Modernet, STSM’s are
particularly intended for Early Stage Researchers and 2 to 3 times per year a call for
application is launched through the Modernet website. The definition of the term “Early
Stage Researcher” (ESR) is based on the time that elapses between the date of the
PhD/Doctorate (or similar experience) and the date of involvement in the COST Action. If
this time span is less than 8 years, a person fits the definition of an ESR. Periods of career
leave, if any, are added to the 8 year time span. Applications are assessed by the chair,
vice-chair and STSM coordinator.
In the first year (2011) no STSMs took place, although there were two workplace visits by
ESR to one of the participating centres without applying for short term scientific mission.
In 2012, three STSMs have been carried out. The reports are published on the website
under STSMs.
-
Andrea Zavadilová (CZ) to Manchester (UK) from 14-06 to 21-06-2012 (Euro 1000):
Developing a system of tracing new occupational diseases in the Czech Republic
Annet Lenderink (Nl) to Trondheim (Norway) from 01-10 to 05-10-2012 (Euro 1000):
The use of registries of work-related diseases as sentinel event system to discover
new OH risk
Vincent Bonneterre (Fr) to Manchester (UK) from 02-10 to 30-11-2012 (Euro 2500):
Studying the synergies between RNV3P and THOR, and their complementary
approaches and methods
In 2013, we reserved a budget for 2 long and 4 short STSMs. A call was launched in
December 2012, June and October 2013. We received 7 applications of which 5 went
through.
-
Nataša Janev Holcer (Croatia) to Helsinki (Fi) from 04-03 to 08-03-2013 (Euro
1200): Study the system of diagnostics of occupational diseases, registrations,
notification and follow-up of occupational diseases
Stefan Mandic (It) to Grenoble from 19-10 till 26-10-2013 (Euro 1100):
Implementation of the RNV3P methodology for the detection of new risks and
diseases in Agriculture
Gaia Varischi (It) to Amsterdam from 04-11 till 10-11-2013 (Euro 1360): The
SIGNAAL system: from the Dutch and Belgian scenario to the Italian agricultural
sector
-
Stefania Curti (It) to Manchester (UK) from 18-11 to 23-11-2013 (Euro 1600):
Application of THOR-GP scheme in other countries
Lynda Bensefa (Fr) to Manchester from 19-11 till 27-11-2013 (Euro 1400):
Comparison of prevention effectiveness of actions in British and French
occupational diseases
2 STSMs of Sofie and Michelia have been postponed due to personal reasons.
-
Michelia Pilleri (It) to Manchester from 04-03 to 03-06-2013 (Euro 1500): Modify the
Thor network to evaluate the real incidence of work related exposure
Sofie Vandenbroeck (Be) to Grenoble from 13-10 to 26-10-2013 (Euro 2500):
Detection of new emerging occupational diseases by using exposome technique
In 2014, we launched a call in January. We received and approved 6 applications. The
following STSMs went through.
-
-
-
Jill Stocks (UK) to Paris (Fr) from 19-05 to 26-05-2013 (Euro 1000): identify and
rank the most frequent OD/exposure combinations occurring within each of the
THOR and RNVP3N datasets.
Madeleine Valenty (Fr) to Manchester (UK) from 02-06 to 06-06-2014 (Euro 800):
compare time trends for MSD and work-related mental ill-health in two countries
(UK and France), with different occupational health organizations.
Yuriko Iwatsubo (Fr) to Manchester (UK) from 02-06 to 06-06-2014 (Euro 800):
compare the French occupational asthma surveillance programme and the UK
THOR programs (SWORD, OPRA).
Sabira Smaili (Fr) to Manchester (UK) from 02-06 to 20-06-2014 (Euro 2400):
analyze time trends of work related mental ill-health and skin diseases reported in
the French WRD surveillance programme, according to two statistical approaches:
Logistic regression or Poisson regression
Begoña Martinez-Jarreta (Sp) to Manchester UK from from 19-08 to 26-08-2013
(Euro 1000): study the application of the thor system in the Spanish context to
encourage physicians especially GPs (General Practitioners) to report occupational
disease voluntarily.
Martijn Schouteden (Be) to Grenoble (Fr) from 29-09 to 03-10-2014 (Euro: 1100):
application of the exposome technique to mine health surveillance data for
occupational related diseases.
III Previous scientific reports
Previous Scientific Report extracted from report of period from 9-11-2010 to 30-032014
II.A Innovative networking
This COST Action succeeded in setting up, for the first time in the EU, a collaborative
network of researchers in the areas of measuring trends in occupational diseases (OD)
and in detecting emerging occupational health risks. It established a baseline of the
knowledge of the type and quality of relevant extant information amongst the participating
states. Furthermore it shared, developed and jointly applied scientific methods for
measuring trends, evaluating interventions, and detecting risks amongst the member
states.
These methods have been put into practice: 10 countries collaborated, for the first time, in
sharing data from their national systems to evaluate and compare trends in the EU. Two
countries implemented a common method to evaluate an EU directive on chromate in
cement. The evidence demonstrated trends in risks of OD, the value of interventions
(including EU directives) on reducing the burden of OD. In these ways and in identifying
emerging risks the Action will therefore contribute in achieving socio-economic impact,
through providing the knowledge needed to prevent, or at least reduce the risk of, OD.
This knowledge has been disseminated (for example most recently at the OccDis
conference in Brussels 2013) and is being further disseminated in the peer reviewed
literature
Working Group 1 undertook a Cochrane Review entitled “Interventions to increase the
reporting of occupational diseases by physicians” which was executed as a direct result of
the COST-Action Modernet. The Protocol was published and since then the Review has
been submitted to the Cochrane Collaboration. There are no previously published reviews
that have evaluated the effect of interventions for increasing the reporting (or reducing the
under-reporting) of OD. We expect that effective interventions could be applied to increase
the reporting of occupational diseases in different contexts and countries. We are
disseminating the information on how this can be done, in the belief that this will
strengthen the quality of EU statistics, and will inform policy makers and others on the
need to reduce risks.
In spite of early indications that ‘Horizon 2020’ would map out to the COST Action agenda,
this has not been evident in the call so far. However other EU funding opportunities and
national programme proposals / projects have been pursued.
II.B. Inter-disciplinary networking
One of the strengths of MODERNET has been its inter-disciplinarity. Thus for example the
work or the 1st working group (WG) on quality of data has relied on close working between
physicians, epidemiologists and statisticians amongst others. Thus the quality criteria
determined by this WG addressed various issues from medical ones of diagnosis and
attribution to statistical ones, and hence in turn underpinned the work of the other WGs. In
such a way, WG1 proposed ideas on how to specify the “ideal” register of data regarding
OD, how to promote and perform evaluation of effectiveness of interventions to increase
OD reporting (new laws or surveillance systems) and how to execute systematic reviews in
the field of aetiology of OD.
Correspondingly WG2 dealing with national trends in WRD and methods for evaluating
interventions, was led by statisticians and epidemiologists, but also involved physicians
and other occupational health specialists closely involved in ‘making’ the data (i.e.
diagnosis) or managing data systems. The data used by this group came from a wide
range of agencies – some closely linked with insurance schemes, others linked to national
health care provision, while other schemes were totally voluntary. In detecting new
hazards, besides medical and toxicology expertise, epidemiology, computer science and
occupational hygiene inter-disciplinarity was especially valuable in WG3. Thus WG3
included experts with skills in text mining from the TNO institute (NL) who had previously
developed an Emerging Risk Identification Support Service in the field of food safety. The
experience of EFSA and their Emrisk unit, dedicated to the detection and expertise of new
risks related to food, was also a source of inspiration, as well as other vigilance methods
(pharmacovigilance, nutrivigilance). Other output relied on collaboration with experts in
Geographic Information Systems or in Quantitative Structure Activity Relationships –
important tools in identifying or predicting new OD hazards. Close links with national
institutions in charge of health and safety was also essential, notably with ANSES in
France who offered a support for the Modernet OccWatch project (mentioned below).
The whole Action worked very coherently both in achieving the above goals and in their
final dissemination through working group 4. An incipient special issue of the peerreviewed journal “Occupational Medicine” will tangibly demonstrate both the outputs
mentioned in the previous section, and the inter-disciplinarity addressed in this section. It
is anticipated that the authoritative findings, validated methods and generalisable
recommendations that will result should therefore besides scientific impacts, also have
socio-economic impacts – for policy makers wishing to determine the burden of OD, the
value of interventions, and the likely emergent threats.
II.C. New networking
During the life of the Action from its first launch in November 2010 about fifty additional
new members joined. The total number of individual participants involved in the Action
work was about 70 at any one time. Of the current 83, there are 35 females (42%) and 24
(29%) Early Stage Researcher (ESR) participants
A key feature of the Action was the active involvement of Early Stage Researchers (ESRs)
both in the processes such as networking activities, and in the output including
presentations at COST Modernet meetings as well as at other conferences such as the
OccDis EU meeting in Brussels in 2013 (the special publication will also demonstrate this).
Although none took place in the first year, a total of fourteen STSMs took place during the
Action thereafter. A number of STSM participants including ESRs took datasets with them
to analyse with the help of staff and methods in the host centre – thus fostering new
collaborations which are being translated into scientific publications. Moreover the
biannual Action conferences and workshops strongly encouraged and featured
presentations by the ESRs guided by their mentors. Therefore in spite of the fact that the
budget precluded the organisation of a Training School as such, extensive and very
customised and detailed practical training was given to the ESRs.
There were participants from two non-COST Countries approved by the CSO. One from
Australia (Prof Malcolm Sim) gave important keynote presentations and engaged in joint
publications (see annex) with Action members. The participant from Albania illustrated the
value of the Action in disseminating good practice beyond the EU and eventually
presented his surveys at one of the Action conference workshops.
A comprehensive project website with user-interactive functions was set up early in the
COST Action: http://www.costmodernet.org/
It informed both participants and the wider public about the aims, structure, composition
and outputs of the project. It also provided a secure forum for online information sharing,
communication and debate between the MODERNET consortium network members.
The website was a first very important project outcome, because registration within it
collected and made easily accessible a significant number of public and private sector
experts, occupational health personnel and stakeholders who have shown interest in our
main aims and objectives and are interested in networking. Before the creation of the
project’s website and the subsequent opening of the request of registration, this potential
large network, strongly linked with timely and urgent EU priorities, did not exist at all. Their
registration and the website visits suggest that, around the “first circle” of active subjects
(mainly MODERNET consortium members), there is also a larger “second circle” of people
interested in the topic and willing to continuously collect updated information on trends of
occupational diseases and new and emerging risks and diseases in the Union.
It is also worth mentioning that the Consortium is actively present in the most important
social networks (LinkedIn, Facebook, Twitter, and Research Gate). Moreover, specific
outreach activities about MODERNET by senior Action members were delivered to nonmembers of the Action in various countries (e.g. by the Chairman in Barcelona - November
2012, Rome - November 2012, Bucharest - May 2013, Paris -October 2013).
Since the last annual report two Management Committee meetings combined with
conferences / workshops have been undertaken (Bucharest - May 2013, Paris -October
2013). They have resulted in tangible interdisciplinary work towards this Cost Action’s
dissemination of its scientific results programme in the peer reviewed literature. Thus a
special edition of the peer-reviewed journal ‘Occupational Medicine’ will feature this COST
Action’s output. Ten publications have been prompted by the Action so far, with a further
12 anticipated in the special edition or elsewhere, although besides these more than a
further hundred relevant to the Action’s objectives of identifying new OD or measuring
trends in OD incidence have been published by MODERNET members. The list of
publications and other outreach activities that resulted from COST networking through the
Action is given in the Annex).
Besides the aforementioned activities, various projects have developed between COST
network colleagues such as collaborative work between FR-UK, IE-UK, BE-FR-NL, as will
be illustrated in the publications and presentations at conferences. Besides the STSMs,
further exchanges were fostered especially of ESRs funded by ERASMUS and other
sources.
Participation in the Action was either an essential feature (as in the Cochrane project) or
an adjuvant asset in members raising research funds; such as €1.8M from UK and IE
governmental agencies for measuring trends in OD in those countries. There was also
collaboration with various national agencies especially the French Institution (ANSES)
supporting the national network for work related disease vigilance and prevention
(RNV3P).
II.D. Self-evaluation
In the opinion of the management committee (MC), the main successes of the Action
were:
 The establishment of a very collegial international and inter-disciplinary network
which included Early Stage Researchers as peers, fostered their enthusiasm and
supported their training needs within the common purposes mentioned below:
 It established and made recommendations on the best means of data collection,
taking account of national feasibility, and the standards of the quality of data
essential to measure and track trends in the burden of occupational disease in the
EU
 The Action developed, shared and jointly applied methods to show trends temporal
trends in the reported incidence of occupational disease (OD) in Europe
 It developed methods to evaluate national or EU level interventions aimed at
reducing the risks of OD
 MODERNET demonstrated collaboratively and internationally the extent to which
interventions (such as EU directives) have been associated with a reduction in the
reported incidence of specific occupational disease
 It developed and internationally applied methods to identify new ‘signals’ of
emerging work related diseases and to help predict new hazards.
 It launched a European sentinel clinical watch system (OccWatch project), designed
to capture case-reports of potentially new work related diseases, to look for similar
cases in other countries, to ensure a common expertise was applied to the cases,
and finally to disseminate information to stakeholders when relevant for preventive
purposes.
 The Action applied a variety of methods (from peer review literature to the Web, and
social media) for the continuing dissemination of the above
 It identified and made reachable a large network of experts and stakeholders
interested in OD trends and new and emerging risks and diseases.
Arguably a drawback of the COST Action is the effort and time involved in the work,
especially with Universities often place emphasis on primary hypothesis driven fully
externally funded research. Nevertheless we in the MC believe that this COST Action has
been an invaluable collaborative opportunity acting as a stepping stone to further
international and interdisciplinary collaborations with scientific as well as socio-economic
impact.
One hopeful expectation was that the Horizon 2020 document in the year preceding the
December 2013 identified the following EU needs of “… improving surveillance and
preparedness…. &… improving scientific tools and methods to support policy
making and regulatory needs ….” which mapped out remarkably well with the agenda,
activity and output of the MODERNET COST Action. However we were frustrated and
disappointed, when these terms were not featured in the official H2020 call of December
2013, and hence we are exploring other avenues for further support of the MODERNET
agenda. For example the extension of the promising tool “OccWatch” tool beyond
Modernet would need support and resources.
Previous Scientific Report extracted from report of period from 9-11-2010 to 15-042013
II.A. Innovative networking

Innovative knowledge resulting from COST networking through the Action. (Specific
examples of Results vs. Objectives)
The main results of the previous years are mentioned in the reports underneath.
 A comprehensive survey of all members was undertaken to collect information
relevant to the overall aims of the Action as well as those of the individual WGs, thus
achieving maximal response efficiently and without undue overlap
 There has been further improvement and development of the website as an eplatform for exchanges between members, as well as other advances in
dissemination [further detailed in Annex 2 below]
 In 2012 work commenced in WG1 on a funded Cochrane collaboration with
networking of several COST Modernet members towards the aim of determining the
best quality methodology for reporting for health surveillance purposes.
 Similarly for WG2 a survey collated information in respect of national data collection
for compensation purposes, with international collaboration in developing methods to
study trends in occupational disease incidence
 Networking on methods for identifying new diseases permitted WG3 to develop and
pilot a strategy for a Sentinel Clinical Watch System. Moreover in this WG as well,
methods developed in one country have been applied to data generated in other
countries.

Significant scientific breakthroughs as part of the COST Action. (Specific examples)
 A joint publication between French and UK teams has been published. It concerns new
methodologies to highlight trends in occupational diseases. (Paris et al. Work-related
asthma in France)
 Approaches have been developed and applied to investigate in a controlled manner
through interrupted time series methods whether interventions at a national level have
an influence on occupational disease incidence (Stocks et al, Occupational &
Environmental Medicine)
 Moreover other presentations at Modernet meetings since then (Manchester, Leuven
and Rome have formed the basis of peer reviewed publications in international journals
as listed elsewhere in this report]

Tangible medium term socio-economic impacts achieved or expected. (Specific examples)
 In general: Results, such as measurable effects of preventive measures on
occupational diseases incidence will also deliver important information from a socioeconomic point of view. Exchanges on potential new occupational diseases, and
identification of new causes of, or circumstances leading to disease should be followed
by social benefit following preventive action
 Specific Examples: Results presented in WG2 and since published showed how
favourable downward trends in occupational disease incidence (asthma and dermatitis)
can be demonstrated at a national level following statutory intervention (e.g., following
the EU directive on CrVI) or other control measures. Other results accepted for
publication and now in press in international journals are addressing whether ’ market
forces’ may have an effect on trends in occupational disease incidence (Stocks et al,
Occupational & Environmental Medicine).

Spin off of new EC RTD Framework Programme proposals/projects. (List)
 The Dutch group has acquired research funding from the EU to participate in an
European project on occupational diseases (Occupational Disease Systems in Europe).
The participation in the COST/Modernet Action was a strong decisive factor for
acquiring the subsidy. The report of this “Progress project” is published in April 2013:
'Report on the current situation in relation to occupational diseases' systems in EU
Member States and EFTA/EEA countries, in particular relative to Commission
Recommendation 2003/670/EC concerning the European Schedule of Occupational
Diseases and gathering of data on relevant related aspects’
http://ec.europa.eu/social/main.jsp?catId=716&langId=en It is available under 'related
documents' in the right-hand side column of the page.

Spin off of new National Programme proposals/projects. (List)
 UK: Participation in the COST Modernet Action has been cited as an enhancing factor
in the awarding of research funds to support The Health and Occupation Research
network (THOR) in the UK [2012-2016] and in the Republic of Ireland [2012-2013]
 Netherlands: A pilot project to develop an online tool for reporting new occupational
health risks by occupational physicians is funded by the Ministry of Social Affairs and
Employment. The project started January 2013 and will be evaluated in 2014. The
online tool should be launched in July 2013. In the project there is strong collaboration
with Belgium and involvement of COST Action WG3 regarding the Sentinel Clinical
Watch System.
 Finland: Involvement in the COST Modernet Action has co-influenced some national
initiatives such as COPD being proposed to be added to the list of occupational
diseases as a compensable disease and set up of a working group on occupational
cancer to prepare a recommendation of the most important occupational carcinogens
and conditions on which the cancer cases can be accepted as occupational diseases
 Czech Republic: Czech participation in COST Action IS1002 gave strong impetus to the
Czech national project aimed at the development of the system for detection of new
occupational diseases in the Czech Republic. Andrea Zavadilová, M.D., who is in
charge of the project, used the advantage of her STSM in Manchester, UK, to learn
from experience of UK and France in that matter. Currently, an on-line questionnaire
inspired by information from some countries involved in the COST Action is under
preparation. The questionnaire is to be filled by general practitioners and other
physicians when a patient suspected of new exposure-disease association is presented
in their office. The awareness of the reporting physicians will be raised using publication
in the journal “General Practitioner” and by oral presentations at various scientific
meetings.
 Albania: Albanian participation focused on asbestos, with the preparation of a
questionnaire addressed at the identification of asbestos contaminated sites in the
Country and the asbestos related diseases.
 Belgium: Precube project; building a data warehouse for the detection and evaluation of
trends of occupational diseases
II.B. Inter-disciplinary networking


Additional knowledge obtained from working with other disciplines within the COST
framework. (Specific examples)
 The output exemplified by the publications mentioned in the previous section and these
and others cited in Annex 1 below have all relied upon, and would have not been
possible without interdisciplinary working between physicians, epidemiologists,
statisticians and others expertise such as hygienists and qualitative research workers.
Of note have been the papers on trends in disease incidence, on the evaluation of
interventions and in identifying signals suggesting new diseases or new circumstances
causing disease
Evaluation of whether the level of inter-disciplinarity is sufficient to potentially provide
scientific impacts. (Specific examples)


Publication in international journals such as ‘Occupational and Environmental Medicine’
as well as citation of these papers by other scientists confirms the scientific impact of
this work
Evaluation of whether the level of inter-disciplinarity is sufficient to potentially provide socioeconomic impacts. (Specific examples)
 In this respect we acknowledge that we have so far inferred a likely impact. We have
however begun liaising with potential partners (whether currently EU funded or not)with
disciplinary strengths that are complementary to ours such as risk assessment, health
economics etc so as to achieve this aim in the longer term
II.C. New networking
 Additional new members joined the Action during its life:
o Ireland, Iceland and FYR of Macedonia joined the Action in 2011; the Institute of
Public Health of Tirana (Albania) was approved as a Non-COST member in 2012.
o An expression of interest from a Turkish academic was warmly welcomed by the MC.
This membership is now being pursued through the Turkish national COST
representative
o In view of the previous withdrawal of the Spanish MC Representative, extensive
consultation within the MC reached a MC consensus on two Spanish academics [in
different institutions] who were to be encouraged to seek membership through their
national representative. Both Spanish nominees have enthusiastically accepted the
opportunity to seek membership.
 Total number of individual participants involved in the Action work.
o The total number of individual participants involved in the Action work is 63 persons
(36 men (57%) and 27 women (43%)).
 Involvement of Early Stage Researchers in the Action, in particular with respect to STSMs,
networking activities, and Training Schools. In addition, justification should be provided if less
than 4 STSMs were carried out during the year.
o Seventeen early stage researchers are involved in the Action. They actively
participate and present orally the work they are involved in by themselves
o Short-Term Scientific Missions aim at strengthening the Modernet COST Action by
allowing scientists to go to an institution in another COST country to foster
collaboration or to learn new techniques (e.g. trend analysis, GIS,…) for discovering
trends in occupational and work-related diseases and tracing new and emerging
risks. In Modernet, STSMs are particularly intended for Early Stage Researchers and
2 times per year a call for application is launched. Applications are assessed by the
chair, vice-chair and STSM coordinator. So far 3 calls have been launched.
o In 2012, three STSMs have been carried out, all three by Early Stage Researchers
(ESR). In brief, Andrea Zavadilová from the Charles University Prague (Czech
Republic) visited the Centre for Occupational & Environmental Health In Manchester
(United Kingdom). Annet Lenderink (Coronel Institute on Work and Health,
Amsterdam, Netherlands) visited the Norwegian Labour Inspection Authority
(Trondheim) and the National Institute on Occupational Health (Oslo ) Vincent
Bonneterre (Centre of Occupational and Environmental Diseases, Grenoble, France)
spend almost three months at the Centre for Occupational & Environmental Health in
Manchester (United Kingdom). For additional information Annex 2.
o For 2013, we reserved a budget for 2 long and 4 short STSMs. A call was launched in
December, 2012. We received 5 applications of which 4 have been approved (1 long
STSM). In the meantime, one STSM has been completed. Dr Nataša Janev Holcer
(Department for Occupational and Environmental Health, Zagreb, Croatia) visited the
Finnish Institute of Occupational Health in Helsinki Finland. The other 3 STSMs are
planned in the second and third trimester of 2013. A new call for STSM will be
launched May 2013.
 Involvement of researchers from outside of COST Countries.
o Australia and Albania participate in the Action as non-COST country. So, the
percentage of participants from countries with reciprocal agreements is 3%. The
representative of Australia is a member of WG1, the representative from Albania is a
member of WG3.
 Advancement and promotion of scientific knowledge through publications and other outreach
activities.
o See Annex 1 for the publications resulting from COST networking through the Action.
Furthermore the network promotes its activities by the website of the network.
(http://www.costmodernet.org/ and the network started a LinkedIn Group COST
Action IS1002 Modernet
http://www.linkedin.com/groups?gid=3879948&trk=hb_side_g.
 Activities and projects with COST network colleagues.
o See Annex 2 for comprehensive the details of the activities and projects in the
Working Groups
 The capacity of the Action members to raise research funds.
o In 2013 the network will be making plans to raise research funds from Horizon 2020
or other research funding sources.
II.D. Self-evaluation
 The main successes of the Action since the start of the third year were:
o Modest expansion in membership, but more importantly an active engagement in one
way or another encompassing the whole range of membership
o A significant increase in STSMs and development of young researchers
o High quality international peer reviewed papers – some bridging the national
memberships
o A comprehensive survey of all members to collect information relevant to the overall
aims of the Action as well as those of the individual WGs Commencing a funded
Cochrane collaboration as part of the quality driven agenda of WG1
o A survey on the availability of national data regarding occupational disease
compensation, and how these data may be influenced by legislation.
o Further methodological enhancements in evaluating the influence of interventions on
trends in incidence of occupational disease (WG2)
o Development and piloting of a strategy for a Sentinel Clinical Watch System for the
purposes of picking up early signals of new disease or circumstances causing
disease
o Application of methods developed in one country for identifying new disease signals
to data collected in other countries
o Further development of the website with public and restricted area for members
www.costmodernet.org, and development of other dissemination media such as a
Facebook page, LinkedIn group for members and other interested researchers and
twitter account @costmodernet
o Developing a strategy for dissemination of joint publications (WG4).
 Drawbacks of the Action in 2012:
o A drawback identified continues to be to manage the inflating number of participating
countries, when the research input of some/many of them is not so strong. If all
expressed interest in Occupational health vigilance, some do not have a research
background, and/or did not initiate projects at a national level. This is partly due to
COST rules (nominations at a national level). However we have begun to be more
pro-active in identifying key individuals or active teams in eligible countries whose
o
o
participation would be of benefit to them as well as strengthening the Modernet
collaboration
Although significant increase in STSMs was evident in the last year when compared
to the previous one, effort continues to be needed to encourage STSMs from a wide
range of countries especially from younger researchers
Another remark concerns the administrative duty of COST project that has often
distracted the attention of the Grant holder. This administrative burden was probably
underestimated.
Previous Scientific Report extracted from report of period from 9-11-2010 to 15-042012
II.A. Innovative networking





Innovative knowledge resulting from COST networking through the Action. (Specific
examples of Results vs. Objectives)
The main results of the 1st year are mentioned in the report hereunder:
 To have achieved inter-disciplinary working e.g. between statisticians,
epidemiologists and occupational physicians(see below)
 Launching of a website with an e-platform for exchanges between members
 In the aftermath of the international congress “Tracing new occupational diseases” in
April 2011 in Amsterdam, the proceedings were published in an International peer
reviewed journal: SH@W Vol. 3, No. 1, Mar. 2012
Significant scientific outputs as part of the COST Action. (Specific examples below)
Tangible medium term socio-economic impacts achieved or expected. (Specific examples)
Spin off of new EC RTD Framework Programme proposals/projects. (List)
o The Dutch group has acquired research funding from the EU to participate in an
European project on occupational diseases (Occupational Disease Systems in
Europe). The participation in the COST/Modernet Action was a strong decisive
factor for acquiring the subsidy. The report of this “PROGRESS report on the
evaluation of Recommendation 2003/670/EC2 concerning the EU schedule of
Occupational Diseases” will be presented to the EU in May 2012. in this report
there is a Chapter on New occupational health hazards in which the
MODERNET COST approach is elucidated. Dr Christa Sedlatschek, the new
director of the European Agency in Bilbao reacted very positive when Gert van
der Laan presented OHS-vigilance with the MODERNET COST activities in
Paris on 15 March 2012 at the conference 'Identifying and recognising
occupational diseases in Europe' organized by EUROGIP.
o Unfortunately, an application for a Marie Curie Intra European Fellowship in
2012-2013:” Advanced training & mentorship in Epidemiology and Geographical
Information Systems: towards a trans-European GIS application to improve
knowledge from Occupational Disease Surveillance Schemes” won’t finally be
funded despite its good scientific evaluation (note: 80/100 > cut off 70; one
fourth of the eligible projects have been funded)
Spin off of new National Programme proposals/projects. (List)
o A project has been submitted at the French level to increase level of information
of all haematopoietic diseases recorded in the RNV3P and apply specific
analyses to this database. If not successful, the analyses will be done on the
existing data
II.B. Inter-disciplinary networking



Additional knowledge obtained from working with other disciplines within the COST
framework. (Specific examples in earlier report below)
Evaluation of whether the level of inter-disciplinarity is sufficient to potentially provide
scientific impacts. (Specific examples in earlier report below)
Evaluation of whether the level of inter-disciplinarity is sufficient to potentially provide socioeconomic impacts. (Specific examples in earlier report below)
II.C. New networking
 Additional new members joining the Action during its life:
o
o







Ireland, Iceland and FYR of Macedonia joined the Action in 2011
The application from the Institute of Public Health of Tirana has not yet been
approved by DC ISCH. The application will be considered for approval by DC ISCH
with electronic procedure in the period from April, 20th to May, 4th 2012
o Interest was shown from institutes in Sweden and Slovakia, which we provided with
information on how to join the action.
Total number of individual participants involved in the Action work.
o The total number of individual participants involved in the Action work is 53 persons
(28 men (53%) and 25 women (47%)).
Involvement of Early Stage Researchers in the Action, in particular with respect to STSMs,
networking activities, and Training Schools. In addition, justification should be provided if less
than 4 STSMs were carried out during the year.
o Seven early stage researchers are involved in the Action. Two workplace visits have
been performed by early stage researchers to one of the participating centres. As a
result of starting up the work in 2011, no STSM’s have been carried out. To stimulate
STSM’s in 2012, the network has appointed an STSM-coordinator (Prof. Lode
Godderis) and WG’s have been asked to provide concrete suggestions for STSM’s in
2012.
o At the latest round of COST Action Workgroup and plenary discussions in
Manchester the following STSM expressions of interest were raised and discussed:
 2 researchers to go from France to the UK to share experiences on
sophisticated statistical methods to analyse trends
 1 researcher from the Czech Republic to go to Belgium and the UK to learn
methodology on data collection for trends in occupational diseases and
identifying new diseases
 1 researcher from Italy to go to the UK to undertake a study of occupational
disease incidence in specific high risk sectors using comparative data from
more than one EU country
Involvement of researchers from outside of COST Countries.
o Australia participates in the Action as non-COST country. So, the percentage of
participants from countries with reciprocal agreements is 2%. The representative of
Australia is a member of WG1.
Involvement of Early Stage Researchers:
o Within the frame of the Modernet activities (as part of collaborations arising from
networking) a junior doctor from the University of Milan will partly be associated, for a
six month period, with the activities of the Grenoble’s team.
Advancement and promotion of scientific knowledge through publications and other outreach
activities.
o See Annex 1 for the publications resulting from COST networking through the Action.
Furthermore the network promotes its activities by the website of the network.
(http://www.costmodernet.org/ and the network started a linkedin Group COST Action
IS1002 Modernet http://www.linkedin.com/groups?gid=3879948&trk=hb_side_g.
Activities and projects with COST network colleagues.
o See Annex 2 for the activities and projects in the Working Groups
The capacity of the Action members to raise research funds.
o For 2012 the network has the ambition to raise research funds from FP7 or other
research funds.
II.D. Self evaluation
 The main successes of the Action since the start of the second year were:
o Installation of new Chair (Raymond Agius) and Vice Chair (Annet Lenderink) and
appointment of a STSM coordinator (Lode Godderis) and a new WG leader for WG1
(Stefano Mattioli) to keep the Action moving.
o Meeting of members of WG1 in Paris, writing a Cochrane proposal on the spot.
o Launch of website in January 2012 with public and restricted area for members
www.costmodernet.org
o
o
Create LinkedIn group for members and other interested researchers.
Presenting COST Modernet and some of our research in a special session at the 30th
ICOH congress in Cancun Mexico on 20 March 2012
o Publishing proceedings and articles presented at the international congress Tracing
New Occupational Diseases in SH@W
o Peer-reviewed publications in other journals (e.g. Occup Env Med) which already
begin to fulfill some of the output targets of COST Modernet
 Drawbacks of the Action in 2011/2012:
o The main drawback identified is probably to manage the inflating number of
participating countries, when the research input of some/many of them is not obvious.
Whereas all expressed interest in Occupational health vigilance, some do not have a
research background, and/or did not initiate projects at a national level. This is partly
due to COST rules (nominations at a national level), but also, we should admit, due to
our lack of active “lobbying” on active teams in other countries we would have like to
work with. We are working to overcome this shortcoming.
o Another remark concerns the administrative duty of COST project that has often
distracted the attention of the Grant holder. This administrative burden was probably
underestimated.
Previous Scientific Report extracted from report of period from 9-11-2010 to 30-112011
II.A. Innovative networking





Innovative knowledge resulting from COST networking through the Action. (Specific
examples of Results vs. Objectives)
The main results of the 1st year are:
1) to have gathered so many different EU partners with interest in occupational
diseases around the same focus of occupational vigilance and to understand more
deeply what are the specificities and expectations of each member
2) to have shared many experiences around this focus, such as, high quality
methodological issues designed by some of the participating teams to address
occupational vigilance, but also information on potentially new occupational
diseases (a more systematic inventory of databases of interest in all participating
countries has also started)
3) to have built an e-platform for exchanges between members
4) to have fixed the work plan of the different groups and the participation of each
member in at least one of them.
5) to have organised under the auspices of the Dutch team, an international
congress attended by more than hundred international experts on occupational
diseases, where the work of Modernet members and other researchers have been
presented “Tracing new occupational diseases” in April 2011 in Amsterdam. The
scientific quality of the event is confirmed by the publication of the proceeding of the
Event in an International peer reviewed journal (in progress at the time of the
delivery of this report).
Significant scientific breakthroughs as part of the COST Action. (Specific examples)
o A first joint publication between French and UK teams is accepted. It concerns
new methodologies to highlight trends in occupational diseases. Paris et al.
Work-related asthma in France: recent trends for the period 2001-2009. The
Journal of Allergy and Clinical Immunology
Tangible medium term socio-economic impacts achieved or expected. (Specific examples)
o In general: Results, such as measurable effects of preventive measures on
occupational diseases incidence will bear important information also from a
socio-economic point of view. Exchanges on potential new occupational
diseases, and search of new cases also may bring such information
o Specific Example: Results presented in WG2 showed how favourable downward
trends in occupational disease incidence (asthma and dermatitis) can be
demonstrated at a national level following statutory intervention (e.g., following
EU directive on CrVI) or other control measures
Spin off of new EC RTD Framework Programme proposals/projects. (List)
o The Dutch group has acquired research funding from the EU to participate in an
European project on occupational diseases (Occupational Disease Systems in
Europe). The participation in the COST/Modernet Action was a strong decisive
factor for acquiring the subsidy.
o Eligible Application for a Marie Curie Intra European Fellowship in 2012-2013:
Project O2DS” Advanced training & mentorship in Epidemiology and
Geographical Information Systems: towards a trans-European GIS application to
improve knowledge from Occupational Disease Surveillance Schemes” (note:
80/100 > cut off 70; final Decision not known at the time being. About one fourth
of the eligible projects will be funded)
Spin off of new National Programme proposals/projects. (List)
o A project has been submitted at the French level to increase level of information
of all haematopoietic diseases recorded in the RNV3P and apply specific
analyses to this database. If not successful, the analyses will be done on the
existing data
II.B. Inter-disciplinary networking



Additional knowledge obtained from working with other disciplines within the COST
framework. (Specific examples)
o Most of the Modernet forces come from disciplines with interest in occupational
health (Occupational Diseases specialists, OD researchers especially
epidemiologists, hygienists and labour inspectors), enriched with some
scientists with fundamental background in statistics, mathematics or
modelisation especially. This allows studying the opportunity of more complex
techniques. Some of us notably the French workers also develop expertise in
Geographical Information Systems.
o Finally one of our member is a policy maker (J Costa David, EU commission),
and The Netherlands and Spain have skills in IT-technologies (web)
Evaluation of whether the level of inter-disciplinarity is sufficient to potentially provide
scientific impacts. (Specific examples)
o As shown by the first publications, inter-disciplinarity is one of the key points that
allows scientific breakthroughs (multi exposure analyses, QSARs, new
methodologies for trends, GIS). This inter-disciplinarity is maybe not sufficiently
represented and shared, as few participating teams benefit from researchers
with this background
Note: QSAR (Quantitative Structure Activity Relationship) development in
occupational diseases (notably occupational asthma) can be limited since data
for the ‘learning set’ can only arise out of actual occupational disease cases (as
the data cannot be generated in experimental animals nor volunteers). The
COST action (especially working group 3) has presented a platform for such
new case data originating from the participating EU states to be provided to
chemists, immunologists and clinicians working on QSAR development and
evaluation (e.g. Seed et al from the UK team)
Evaluation of whether the level of inter-disciplinarity is sufficient to potentially provide socioeconomic impacts. (Specific examples)
o On the other hand, we think our level of inter-disciplinarity focused on
diagnosing, taking care and preventing occupational diseases, is sufficient to
help provide information with socio economic impacts
II.C. New networking
 Additional new members joining the Action during its life:
o Ireland, Iceland, and Macedonia entered the network after its start in November 2011.
Albania has applied for membership.
 Total number of individual participants involved in the Action work.
o The total number of individual participants involved in the Action work is 49 persons
(25 men (51%) and 24 women (49%)).
 Involvement of Early Stage Researchers in the Action, in particular with respect to STSMs,
networking activities, and Training Schools. In addition, justification should be provided if less
than 4 STSMs were carried out during the year.
o Five early stage researchers are involved in the Action. Two workplace visits have
been performed by early stage researchers to one of the participating centres. As a
result of starting up the work in 2011, no STSM’s have been carried out. To stimulate
STSM’s in 2012, the network will appoint an STSM-coordinator and WG’s have been
asked to provide concrete suggestions for STSM’s in 2012.
o At the latest round of COST Action Workgroup and plenary discussions in
Manchester the following STSM expressions of interest were raised and discussed:






2 researchers to go from France to the UK to share experiences on
sophisticated statistical methods to analyse trends
 1 researcher from the Czech Republic to go to Belgium and the UK to learn
methodology on data collection for trends in occupational diseases and
identifying new diseases
 1 researcher from Italy to go to the UK to undertake a study of occupational
disease incidence in specific high risk sectors using comparative data from
more than one EU country
Involvement of researchers from outside of COST Countries.
o Australia participates in the Action as non-COST country. So, the percentage of
participants from countries with reciprocal agreements is 2%. The representative of
Australia is a member of WG1.
Involvement of Early Stage Researchers:
o In the frame of the Modernet activities it has been organized a stage of a junior doctor
of the University of Milan who will partly be associated, for a six month period, to
activities of the Grenoble’s team.
Advancement and promotion of scientific knowledge through publications and other outreach
activities.
o See Annex 1 for the publications resulting from COST networking through the Action.
Furthermore the network promotes its activities by the website of the network.
(http://demo2.costmodernet.org/ and the network started a linkedin Group COST
Action IS1002 Modernet
http://www.linkedin.com/groups?gid=3879948&trk=hb_side_g.
Activities and projects with COST network colleagues.
o See Annex 2 for the activities and projects in the Working Groups
The capacity of the Action members to raise research funds.
o For 2012 the network has the ambition to raise research funds from FP7 or other
research funds.
II.D. Self evaluation
 The main successes of the Action in 2011 were:
o The establishment of a group of nearly 50 persons with expertise on occupational
diseases, which generated very interesting discussions on how to improve monitoring
occupational diseases, analyzing trends, tracing new occupational risks and
distribution of knowledge on the issue. Furthermore getting acquainted with the work
of colleagues by the presentations during the meetings in Amsterdam and
Manchester has been very stimulating scientifically.
o The activities of the WGs are described in annex 2. Working plans have been made
for 2012.
o Finally the development (officially launched January 2012) of an own network website
and a LinkedIn group is a success.
 Drawbacks of the Action in 2011:
o The main drawback identified is probably to manage the inflating number of
participating countries, when the research input of some/many of them is not obvious.
If all expressed interest in Occupational health vigilance, some do not have a
research background, and/or did not initiate projects at a national level. This is partly
due to COST rules (nominations at a national level), but also, we should admit, due to
our lack of active “lobbying” on active teams in other countries we would have like to
work with.
o Another remark concerns the administrative duty of COST project that has often
distracted the attention of the Grant holder. This administrative burden was probably
underestimated.
Annex of COST Action references
1.
Papers which the Action helped significantly in / which might not have happened
without the action (including any provisionally accepted)
Agius R, Bonneterre V, Sim M. What do surveillance schemes tell us about occupational
diseases? Chapter 11 p131-141 in Current Topics in Occupational Epidemiology. 288p.
Editeur Katherine Venables. Oxford University Press. Oxford, August 2013 ISBN:
9780199683901 Current Topics in Occupational Epidemiology
Le Barbier M, Bonneterre V, Ameille J, Telle Lamberton M, Lasfargues G. (2012) Le
Réseau National de Vigilance et de Prévention des Pathologies Professionnelles (rnv3p) :
structure du réseau et organisation de l’émergence clinique. Arch. Mal. Prof. Env 73(3),
413-415
Bonneterre V, Telle Lamberton M. (2012) Surveillance épidémiologique et vigilance en
milieu professionnel : place du réseau Européen MODERNET (Occupational health
vigilance: role of the European Network MODERNET). Arch. Mal. Prof. Env 73(3), 419-421
Bonneterre V. (2013) “What really stands beyond the numbers?”: Diseases and the social
construction of Disease. Occup Environ Med 70, 437–438. (Invited Commentary related to
Carder M et al. (2013) Time trends in the incidence of work-related mental ill-health and
musculoskeletal disorders in the UK. Occup Environ Med 70, 317–24)
Carder M, Mattioli S, Bensefa-Colas L, Stikova E, Noone P, Samant Y, Sludds K, Valenty
M, Wannag A, Telle-Lamberton M. A review of the occupational disease monitoring
systems in the Modernet consortium. (In preparation)
Curti S, Sauni R, Spreeuwers D, De Schryver A, Valenty M, Riviere S, Mattioli S.
Interventions to increase the reporting of occupational diseases by physicians. Cochrane
review (submitted).
Mattioli S, Sauni R, Spreeuwers D, De Schryver A, Valenty M, Rivière S, Curti S.
Interventions to increase the reporting of occupational diseases by physicians (Protocol).
Cochrane Database Syst Rev. 2013;(1):CD010305.
Mattioli S, Gori D, Di Gregori V, Ricotta L, Baldasseroni A, Farioli A, Zanardi F, Galletti S,
Colosio C, Curti S, Violante FS. (2013) PubMed search strings for the study of agricultural
workers' diseases. Am J Ind Med 56(12), 1473-81.
Money A, Carder M, Noone P, Bourke J, Hayes J, Turner S, Agius R, Work-related illhealth: Republic of Ireland, Northern Ireland, Great Britain 2005–2012 Occupational
Medicine Advance Access published October 16, 2014
Paris C, Ngatchou-Wandji J, Luc A, McNamee R, Bensefa-Colas L, Larabi L, TelleLamberton M, Herin F, Bergeret A, Bonneterre V, Brochard P, Choudat D, Dupas D,
Garnier R, Pairon JC, Agius R , Ameille J, the members of the RNV3P. (2012) Workrelated asthma in France: recent trends for the period 2001-2009. Occup Environ Med
69(6), 391-397.
Stocks SJ, McNamee R et al. Trends in incidence of occupational diseases across 10
European Countries (2000-2012). Under review (Occup Environ Med)
2. Other papers that are related to the Modernet agenda (including any
provisionally accepted)
Aalto-Korte K, Henriks-Eckerman ML, Kuuliala O, Jolanki R. (2010) Occupational
methacrylate and acrylate allergy - cross-reactions and possible screening allergens.
Contact Dermatitis 63(6), 301-312.
Aalto-Korte K, Pesonen M, Kuuliala O, Alanko K, Jolanki R. (2010) Contact allergy to
aliphatic polyisocyanates based on hexamethylene-1,6-diisocyanate (HDI). Contact
Dermatitis 63(6), 357-63.
Aalto-Korte K, Suuronen K, Kuuliala O, Henriks-Eckerman M, Jolanki R. (2012)
Occupational contact allergy to monomeric isocyanates. Contact Dermatitis 67(2), 78-88.
Aalto-Korte K. (2013) Contact allergy from metal-working fluid traced to tall oil fatty acids
monoethanolamide. Contact Dermatitis 69(5), 261-322.
Aalto-Korte K. (2013) Occupational contact allergy to the epoxy methacrylate 2,2-bis[4-(2methacryloxyethoxy)phenyl] propane in an anaerobic glue. Contact Dermatitis 68(5), 314315.
Ackermann L, Aalto-Korte K, Alanko K, Hasan T, Jolanki R, Lammintausta K, Lauerma A,
Laukkanen A, Liippo J, Riekki R, Vuorela AM, Rantanen T. (2011) Contact sensitization to
methylisothiazolinone in Finland - a multicentre study. Contact Dermatitis 64(1), 49-53.
Airaksinen L, Pallasaho P, Voutilainen R, Pesonen M. (2013) Occupational rhinitis,
asthma, and contact urticaria caused by hydrolyzed wheat protein in hairdressers [letter].
Ann Allergy Asthma Immunol 111(6),577-9.
Barbieri MT, Cocco ME, Cocco P. (2013) Prevalence of atopy in occupational allergic
contact dermatitis: comparison of diagnostic techniques. Med Lav 104, 460-466. [in
Italian]
Bensefa-Colas L, Telle-Lamberton M, Paris C, Faye S, Stocks JS, Luc A, Bourrain J_L,
M.-N. Crépy, D. Dupas, P. Frimat, R. Garnier, M.-P. Lehucher-Michel, J.-C. Pairon, J.-M.
Soulat, G.Lasfargues, D. Choudat, the members of the RNV3P and I. Momas.
Occupational allergic contact dermatitis and major allergens in France: temporal trends for
the period 2001-2010. BDJ 2014.
Béranger R, Hoffman P, Christin-Maitre S, Bonneterre V. (2012) Occupational exposures
to chemicals as a possible etiology in premature ovarian failure: a critical analysis of the
literature. Reprod Toxicol 33(3), 269-279.
Bonneterre V, Bicout DJ, de Gaudemaris R, on behalf of the RNV3P. (2012) Application of
Pharmacovigilance methods in Occupational Health Surveillance. Safety and Health at
Work (SH@W) 3(2), 92-100.
Bonneterre V, Faisandier L, Bicout DJ, Bernardet C, Piollat J, Ameille J, De Clavière C,
Aptel M, Lasfargues G, de Gaudemaris R, RNV3P. (2010) Programmed health
surveillance and detection of emerging diseases in occupational health: contribution of the
French national occupational disease surveillance and prevention network (RNV3P).
Occup Environ med 67(3), 178-186
Brandi G, Di Girolamo S, Farioli A, de Rosa F, Curti S, Pinna AD, Ercolani G, Violante FS,
Biasco G, Mattioli S. (2013) Asbestos: a hidden player behind the cholangiocarcinoma
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Campagna M, Satta G, Flore V, Ibba A, Meloni M, Tocco MG, Atzeri S, Avataneo G, Flore
C, Campo L, Fustinoni S, Bertazzi P, Cocco P. (2011) Use of urinary benzene in
biomonitoring low level environmental exposure. G Ital Med Lav Ergon 33(3 suppl), 39-42.
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Campagna M, Virgola P, Tamponi M, Casu A, Piquereddu C, Doro M, Manconi D,
Demurtas A, Setzu D, DelRio A, Cocco P, Flore C, Meloni M. (2011) Health surveillance
among hospital workers exposed to biological agents transmissible via blood in three
Italian hospitals. G Ital Med Lav Ergon 33 (3 suppl)1:282. [in Italian]
Campagna M, Satta G, Campo L, Flore V, Ibba A, Meloni M, Tocco MG, Avataneo G,
Flore C, Fustinoni S, Cocco P. (2012) Biological monitoring of low-level exposure to
benzene. Med Lav 103, 338-46.
Carder M, Money A, Turner S and Agius RM. Estimated incidence rates of work-related
illness for GB occupational physicians. Occup Med. In press
Carder M, McNamee R, Turner S, Hodgson J, Holland F, Agius RM. (2013) Time trends in
the incidence of work-related mental ill-health and musculoskeletal disorders in the UK.
Occup Environ Med 70, 317-324.
Carder M, McNamee R, Turner S, Hussey L, Money A and Agius RM. (2011) Improving
estimates of incidence of specialist diagnosed, work-related respiratory and skin disease in
Great Britain. Occupational Medicine 61(1), 33-39
Cocco P. (2011) Retrospective assessment of occupational exposures: principles and
methods. G Ital Med Lav Ergon 32(4 Suppl), 292-4. [in Italian]
Cocco P. (2011) Silica and lung cancer: state of the art, practical implications and future
research. Foreword. Med Lav 102:307-9.
Cocco P. (2011) Silica and lung cancer. What next? Med Lav 102, 368-9.
Cocco ME, Scanu V, Barbieri MT, Cocco P. (2011) Occupational respiratory allergy: a
descriptive analysis and agreement between diagnostic tests. G Ital Med Lav Ergon
33/3suppl, 1-299. [in Italian]
Cocco P, Satta G, D'Andrea I, Nonne T, Udas G, Zucca M, Mannetje AT, Becker N,
Sanjosé SD, Foretova L, Staines A, Maynadié M, Nieters A, Brennan P, Ennas MG,
Boffetta P. (2013) Lymphoma risk in livestock farmers: Results of the Epilymph study. Int J
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Cocco P, Satta G, Dubois S, Pili C, Pilleri M, Zucca M, 't Mannetje AM, Becker N,
Benavente Y, de Sanjosé S, Foretova L, Staines A, Maynadié M, Nieters A, Brennan P,
Miligi L, Ennas MG, Boffetta P. (2013) Lymphoma risk and occupational exposure to
pesticides: results of the Epilymph study. Occup Environ Med 70, 91-8.
Cocco P, Vermeulen R, Flore V, Nonne T, Campagna M, Purdue M, Blair A, Monnereau A,
Orsi L, Clavel J, Becker N, de Sanjosé S, Foretova L, Staines A, Maynadié M, Nieters A,
Miligi L, 't Mannetje A, Kricker A, Brennan P, Boffetta P, Lan Q, Rothman N. (2013)
Occupational exposure to trichloroethylene and risk of non-Hodgkin lymphoma and its
major subtypes: a pooled InterLymph analysis. Occup Environ Med 70, 795-802
Curti S, Coggon D, Baldasseroni A, Cooke RM, Fresina M, Campos EC, Semeraro F,
Zanardi F, Farioli A, Violante FS, Mattioli S. (2014) Incidence rates of surgically treated
rhegmatogenous retinal detachment among manual workers, non-manual workers and
housewives in Tuscany, Italy. Int Arch Occup Environ Health 87(5), 539-45
Désiron HA, Donceel P, Godderis L, Van Hoof E, de Rijk A. What is the value of
occupational therapy in return to work for breast cancer patients? A qualitative
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asthma in professional cleaning work: clinical study. Occupational Medicine 61, 121–126.
Mattioli S, Curti S, De Fazio R, Cooke RMT, Zanardi F, Bonfiglioli R, Farioli A, Violante FS.
(2012) Occupational lifting tasks and retinal detachment in non-myopics and myopics:
extended analysis of a case-control study. Saf Health Work 3(1), 52-7.
Mattioli S, Zanardi F, Baldasseroni A, Schaafsma F, Cooke RM, Mancini G, Fierro M,
Santangelo C, Farioli A, Fucksia S, Curti S, Violante FS, Verbeek J. (2010) Search strings
for the study of putative occupational determinants of disease. Occup Environ Med 67(7),
436-43.
McNamee R, Chen Y, Hussey L, and Agius RM. (2010) Randomised Controlled Trial
comparing time-sampled versus continuous time reporting for measuring incidence.
Epidemiology 21(3), 376-378
Meloni M, Setzu D, Del Rio A, Campagna M, Cocco P. (2013) QTc interval and
electrocardiographic changes by type of shift work. Am J Ind Med 56, 1174-9.
Meloni M, Setzu D, Del Rio A, Cocco P. Continuous vocational training and its effects on
work ability. In: Nygard C-H, Savinainen M, Kirsi T, Lumme-Sandt K (eds). Age
management during the Life Course. Proceedings of the 4 th Symposium on Work Ability.
Tampere, Finland: Tampere University press, 2011, pp 336-341.
Meloni M, Daga F, Del Rio A, Setzu D, Campagna M, Miazzi G, Cocco P. (2011) The work
capacity index and its applciation in hospital workers. G Ital Med Lav Ergon 33/3suppl
1:294. [in Italian]
Meloni M, Miazzi G, Campagna M, Del Rio A, Daga F, Setzu D, Pilleri M, Cocco P. (2011)
Shiftwork: effects on human health and work organization in various industries. G Ital Med
Lav Ergon 33/3suppl 1:376. [in Italian].
Miligi L, Benvenuti A, Mattioli S, Salvan A, Tozzi GA, Ranucci A, Legittimo P, Rondelli R,
Bisanti L, Zambon P, Cannizzaro S, Kirchmayer U, Cocco P, Celentano E, Assennato G,
Merlo DF, Mosciatti P, Minelli L, Cuttini M, Torregrossa V, Lagorio S, Haupt R, Risica S,
Polichetti A; SETIL Working Group, Magnani C (2013). Risk of childhood leukaemia and
non-Hodgkin's lymphoma after parental occupational exposure to solvents and other
agents: the SETIL Study. Occupational and Environmental Medicine. 70(9), 648-55
Miedema HS, Molen HFvd, Kuijer PPFM, Koes BW, Burdorf A. Incidence of low back pain
related occupational diseases in the Netherlands. European Journal of Pain, published
online. doi:10.1002/j.1532-2149.2013.00430.x
Miranda H, Kaila-Kangas L, Heliövaara M, Leino-Arjas P, Haukka E, Liira J, Viikari-Juntura
E. (2010) Musculoskeletal pain at multiple sites and its effects on work ability in a general
working population. Occupational and Environmental Medicine 67(7), 449-455.
Molen HFvd, Kuijer PPFM, Smits PBA, Schop A, Moeijes F, Spreeuwers D, Frings-Dresen
MHW (2012). Annual incidence of occupational diseases in economic sectors in the
Netherlands. Occupational and Environmental Medicine 69(7), 519-521.
Money A, Carder M, Turner S and Agius RM. (2011) Incidence of work-related
occupational hearing loss in the UK: OSSA. Occupational Medicine 61(4), 226-233
Money A, Hussey L, Thorley K, Turner S and Agius RM. (2010) Work-related sickness
absence negotiations: general practitioners' qualitative perspective. British Journal of
General Practice 60(579), 721-8.
Mullie, P., Godderis, L., Clarys, P. (2012). Determinants and nutritional implications
associated with low-fat food consumption. Appetite 58(1), 34-38.
Nakládalová, M., Ehler, E., Urban, P. (2010). Occupational Damage to the Ulnar Nerve at
the Elbow Region (in Czech), Čs. Neurol. Neurochir. 73/106: S93
Nakládalová, M., Ehler, E., Pelclová, D., Urban, P. et al. (2013). Low Back Pain as an
Occupational Disease (in Czech), Čs. Neurol. Neurochir. 76/109: S44-45
Pelclová, D., Fenclová, Z., Urban, P. (2011). Occupational cancer in the Czech Republic –
The tip of the iceberg? Eur. J. Oncol. 16: 149-161
Perrotta C, Staines A, Codd M, Kleefeld S, Crowley D, T Mannetje A, Becker N, Brennan
P, Sanjosé S, Foretova L, Maynadié M, Nieters A, Boffetta P, Cocco P. (2012) Multiple
Myeloma and lifetime occupation: results from the EPILYMPH study. J Occup Med Toxicol
7:25.
Perrotta C, Kleefeld S, Staines A, Tewari P, De Roos AJ, Baris D, Birmann B, Chiu B,
Cozen W, Becker N, Foretova L, Maynadié M, Nieters A, de Sanjosé S, Miligi L, Seniori
Costantini A, Purdue M, Spinelli J, Cocco P. (2013) Multiple myeloma and occupation: A
pooled analysis by the International Multiple Myeloma Consortium. Cancer Epidemiol 37,
300-5.
Pesonen M, Kuuliala O, Henriks-Eckerman M, Aalto-Korte K. (2012) Occupational allergic
contact dermatitis caused by eye-lash extension glues. Contact Dermatitis 67(5), 247-320.
Pirodda A, Ferri GG, Mattioli S, Violante FS. (2013) Perilymphatic Fistula: An often
Unrecognized Occupational Handicap? A Review of the Literature and Some Consequent
Remarks. J Int Adv Otol 9(3), 383-6.
Pralong JA, Seed MJ, Cartier A, Agius RM, Labrecque M. (2012) Is there a place for a
computer based asthma hazard prediction model in clinical practice? Occup Environ
Med 69(10), 771-2.
Puligheddu M, Conti S, Campagna M, Meloni M, Pau M, Marrosu F, Cocco P. (2012)
Cancer risk among shiftworkers: review of the literature . G Ital Med Lav Ergon
3/suppl:624-626 [in Italian]
Rice C, Jin N, Cocco P, Dosemeci M, Buncher CR. (2011) The exposure metric: does
including time since exposure in the calculation of working lifetime exposure provide a
better understanding of disease risk than the cumulative exposure? Med Lav 102, 343-9
Satta G, Dubois S, Perrotta C, Pilleri M, D’Andrea I, Ennas MG, Lecca M, Nonne T, Zucca
M, ‘t Mannetje A, Becker N, de Sanjosé S, Foretova L, Staines A, Maynadié M, Nieters A,
Brennan P, Boffetta P, Cocco P. (2011) Risk of multiple myeloma and agricultural
exposures. G Ital Med Lav Ergon 33/suppl 3:106-107. [in Italian]
Satta G, D’Andrea I, Ursi M, Nonne T, Avataneo G, Campagna M, Cocco P. (2012) Risk of
the most prevalent lymphoma subtypes associate with use of mobile phones. G Ital Med
Lav Ergon 3/suppl:621-623 [in Italian]
Sauni R, Linna A, Oksa P, Nordman H, Tuppurainen M, Uitti J. (2010) Cobalt asthma - a
case series from a cobalt plant. Occup Med (London) 60(5), 369-75.
Seed M, Agius RM. (2011) Further corroboration of the asthmagenicity of 5-aminosalicylic
acid. Occup Environ Med 68(5) 386.
Stocks SJ, McNamee R, Turner S, Carder M, Agius RM. (2013) Assessing the impact of
national level interventions on workplace respiratory disease in the UK: part 1 - changes in
workplace exposure legislation and market forces. Occup Environ Med 70(7), 476-82
Stocks SJ, McNamee R, Turner S, Carder M, Agius RM. (2013) Assessing the impact of
national level interventions on workplace respiratory disease in the UK: part 2 - regulatory
activity by the Health and Safety Executive. Occup Environ Med 70(7), 483-90
Stocks SJ, McNamee R, Turner S, Carder M, Agius RM. (2012) Has EU legislation to
reduce exposure to chromate reduced allergic contact dermatitis (UK)? Occup Environ
Med 69, 150-152.
Stocks SJ, Turner S, McNamee R, Carder M, Hussey L and Agius RM. (2011) Occupation
and work-related ill-health in UK construction workers. Occupational Medicine 61, 407-415
Stocks SJ, Turner S, Carder M, Hussey L, McNamee R, Agius RM. (2010) The incidence
of medically reported work-related ill-health in the UK agricultural sector. Occupational
Medicine 60(5), 340-7.
Stocks SJ, McNamee R, Turner S, Carder M, Agius R. (2010) The incidence of medically
reported work-related ill-health in the construction industry. Short report to Occupational
and Environmental Medicine 67, 574-576
Suojalehto H, Lindström I, Henriks-Eckerman M, Jungewelter S, Suuronen K. (2011)
Occupational Asthma Related to Low Levels of Airborne Methylen Diphenyl Diisocyanate
(MDI) in Orthopedic Casting Work. Am. J. Ind. Med 54(12), 906-910.
Suuronen K, Pesonen M, Aalto-Korte K. (2012) Occupational contact allergy to
cocamidopropyl betaine and its impurities. Contact Dermatitis 66(5), 286-292.
Suuronen K, Pesonen M, Henriks-Eckerman M, Aalto-Korte K. (2013) Triphenyl phosphite,
a new allergen in polyvinylchloride gloves. Contact Dermatitis 68(1), 1-64.
Tooker BC, Newman LS, Bowler RP, Karjalainen A, Oksa P, Vainio H, Pukkala E, BrandtRauf PW. (2011) Proteomic detection of cancer in asbestosis patients using SELDI-TOF
discovered serum protein biomarkers. Biomarkers 16(2), 181-91.
Turner S, McNamee R, Agius R, Wilkinson SM, Carder M, Stocks SJ. (2012) Evaluating
interventions aimed at reducing occupational exposure to latex and rubber glove allergens
Occup Environ Med 69, 925-931
Turner S, McNamee R, Roberts C, Bradshaw L, Curran A, Francis M, Fishwick D, Agius
RM. (2010) Agreement in diagnosing occupational asthma by occupational and respiratory
physicians who report to surveillance schemes for work-related ill-health. Occupational
and Environmental Medicine 67, 471-478.
Urban, P., Pelclová, D. (2010). Information about Up-Date of the Czech List of
Occupational Diseases (in Czech), Pracovní lékařství 62, 202-203
Vandersmissen GJ, Verhoogen RA, Van Cauwenbergh AF, Godderis L. Determinants
of maximal oxygen uptake (VO2 max) in fire fighter testing. Appl Ergon. 2014
Jul;45(4):1063-6. doi: 10.1016/j.apergo.2014.01.001. Epub 2014 Jan 21. PubMed
PMID: 24456897.
Van Landuyt, K., Nawrot, T., Geebelen, B., De Munck, J., Snauwaert, J., Yoshihara, K.,
Scheers, H., Godderis, L., Hoet, P., Van Meerbeek, B. (2011). How much do resin-based
dental materials release? A meta-analytical approach. Dental Materials 27(8), 723-747.
Van Landuyt KL, Yoshihara K, Geebelen B, Peumans M, Godderis L, Hoet P, Van
Meerbeek B. Should we be concerned about composite (nano-)dust? Dent Mater. 2012
Nov;28(11):1162-70. doi: 10.1016/j.dental.2012.08.011. Epub 2012 Sep 20. PubMed
PMID: 22999371.
Van Royen K, Remmen R, Vanmeerbeek M, Godderis L, Mairiaux P, Peremans L. A
review of guidelines for collaboration in substance misuse management. Occup Med
(Lond). 2013 Sep;63(6):445-7. doi: 10.1093/occmed/kqt089. Epub 2013 Jul 23.
Review. PubMed PMID: 23881120.
Vehmas T, Oksa P, Kivisaari L. (2012) Lung and pleural CT signs predict deaths: 10-year
follow-up after lung cancer screening of asbestos-exposed workers. International Archives
of Occupational and Environmental Health 85(2), 207-13.
Verhaert N, Moyaert N, Godderis L, Debruyne F, Desloovere C, Luts H. Noise
exposure of care providers during otosurgical procedures. B-ENT. 2013;9(1):3-8.
PubMed PMID: 23641584.
Vierikko T, Järvenpää R, Toivio P, Uitti J, Oksa P, Lindholm T, Vehmas T. (2010) Clinical
and HRCT screening of heavily asbestos-exposed workers. Int Arch Occup Environ
Health. 83(1), 47-54.
Zanardi F, Salvarani R, Cooke RM, Pirastu R, Baccini M, Christiani D, Curti S, Risi A,
Barbieri A, Barbieri G, Mattioli S, Violante FS (2013) Carcinoma of the Pharynx and
Tonsils in an Occupational Cohort of Asphalt Workers. Epidemiology 24(1), 100-3.
Zanardi F, Cooke RM, Maiorana A, Curti S, Farioli A, Bonfiglioli R, Violante FS, Mattioli S.
(2011) Is this case of a very rare disease work-related? A review of reported cases of
Pacinian neuroma. Scand J Work Environ Health 37(3), 253-8.
3. Presentations / conference precedings directly relevant to the Modernet agenda
AND BASED ON MODERNET collaborations at meetings other than Modernet
Aalto-Korte K. Methylisothiazolinone allergy in patients with occupational allergic contact
dermatitis [abstract]. Contact Dermatitis. 2012;66 Suppl 2S1-92. 11th Congress of the
European Society of Contact Dermatitis (ESCD), 13–16 June 2012, Malmö, Sweden
Aalto-Korte K. Occupational contact allergy to isocyanates [abstract]. Contact Dermatitis.
2012;66 Suppl 2S92. 11th Congress of the European Society of Contact Dermatitis
(ESCD), 13–16 June 2012, Malmö, Sweden
Le Barbier M, Bonneterre V, Ameille J, Telle Lamberton M. Le Réseau National de
Vigilance et de Prévention des Pathologies Professionnelles (rnv3p): structure du réseau
et organisation de l’émergence clinique. 32e congrès de médecine et santé au travail,
Clermont Ferrand 5-8 juin 2012 (related article in Arch. Mal. Prof. Env cited above)
Bonneterre V on behalf of Modernet and RNV3P. New techniques for tracing newly
occurring work-related diseases – sentinel and alert systems. Workshop on Occupational
Burden of Disease organized by EU-OSHA, Brussels, 10 October 2014
Bonneterre V, Faye S, Le Barbier M on behalf of Modernet WG3. The Occupational
Diseases sentinel Clinical Watch System project (OccWatch): a model to be generalised?
EU commission’s launched Conference “Occupational Diseases in the EU, The system(s)
and their role, “together for disease-free workers”, Brussels, 3rd & 4th December 2013
Bonneterre V, Telle Lamberton M. Surveillance épidémiologique et vigilance en milieu
professionnel : place du réseau Européen MODERNET. 32e congrès de médecine et
santé au travail, Clermont Ferrand 5-8 juin 2012 (related article in Arch. Mal. Prof. Env
cited above)
Bonneterre V, pour le RNV3P. RNV3P : vers une dimension européenne : Modernet.
Symposium AFSSET lors du 31e congrès de national de médecine et santé au Travail,
Toulouse, 1-4 Juin 2010. Invitation
Bonneterre V. “Collaboration between RNV3P and THOR: An Entente Cordiale”. Lane
Symposium, Centre of Occupational and Environmental Health, the Manchester
University. Novembre 2012
Bonneterre V, Lagrange E. Amyotrophic Lateral Sclerosis: Looking for environmental risk
factors. Centre for Occupational and Environmental Health Seminars. The University of
Manchester, 1st Novembre 2012.
Bonneterre V, Pontin F, Bicout DJ, Agius R, de Gaudemaris R, on behalf of rnv3p, THOR,
and MODERNET networks. Searching for signals of potentially new disease-exposure
associations: Interest of screening work-related diseases surveillance databases with Data
Mining approaches? EPICOH 2013, Utrecht. Com. Orale in Mini-symposium « improving
the impact of occupational diseases surveillance »
Carder M, Bensefa L, Estikova E, Mattioli S, Noone P, Rivière S, Samant Y, Sludds K,
Telle-Lamberton M, Valenty M, Wannag A. EU existing systems recording OD/WRD. EU
commission’s launched Conference “Occupational Diseases in the EU, The system(s) and
their role, “together for disease-free workers”, Brussels, 3rd & 4th December 2013
Cocco P. Retrospective assessment of occupational exposures: translational applications
to the occupational health practice. ICOH Conference on Education and Training in
Occupational Health: Healthy Working Lives for All: Crossing the OH Multidisciplinary
Interface. 8th International Conference on Education and Training in Occupational Health,
Glasgow 10-12 April, 2008.
Cocco P. Cesare Cappio Borlino, Carlo Manca, Giorgio Marracini. An ICT application for
real time surveillance and prompt discovery of emerging new occupational health hazards.
International Congress on Tracing New Occupational Diseases: methodology, recent
findings, and implications for OHS policy. Amsterdam, 7-8 April 2011
Curti S, Mattioli S, Baldasseroni A, Zanardi F, Cooke RMT, Farioli A, Violante FS, Coggon
D. Distacco di retina e lavoro: incidenza della patologia tra addetti ad attività manuale o
non manuale (Toscana, 1997-2005). Convegno Nazionale delle Scuole Italiane di
Medicina del Lavoro. Taormina, 10-12 ottobre 2010. Abstracts Book, p. 45.
Curti S, Mattioli S, Baldasseroni A, Cooke RMT, Zanardi F, Farioli A, Violante FS, Coggon
D. Incidence rates of surgically treated rhegmatogenous retinal detachment among
manual workers, non-manual workers and housewives in Tuscany, Italy. 22nd
International Conference on Epidemiology in Occupational Health. EPICOH 2011. Oxford,
UK, 7-9 September 2011. Abstracts book, p. 54.
Delaunay M, Godard V, Faye S, Bicout DJ, de Gaudemaris R, Bonneterre V, on behalf of
rnv3p. How using Geographical Information Systems (GIS) could allow us to improve
Occupational Diseases (OD) surveillance? EPICOH 2013, Utrecht. Com. Orale in Minisymposium « improving the impact of occupational diseases surveillance »
Dik S, Hoet P, De Smet K, Van Der Straeten C, Scheepers P, Godderis L. (2011). The role
of chromium in pseudotumor induction and survival. 41st European Mutagen Annual
Meeting. Barcelona, 4-7 Jyly 2011.
Dik A, Tabish A, Scheepers P, Godderis L. (2011). Effects of Environmental Stressors on
Histone Modifications: A Systematic Review. Trends in Metals Toxicity and Ecotoxicity.
Mechelen, 8 December 2011.
Farioli A, Mattioli S, Zanardi F, Baldasseroni A, Schaafsma F, Cooke RMT, Mancini G,
Fierro M, Santangelo C, Fucksia S, Curti S, Violante FS, Verbeek J. Eziologia
professionale di una malattia: proposta di stringhe di ricerca per la consultazione di
PubMed. Convegno Nazionale delle Scuole Italiane di Medicina del Lavoro. Taormina, 1012 ottobre 2010. Abstracts Book, p. 29.
Godderis L. (2013). Impact of Environment on the Epigenome. LBMCC seminar. Kirchberg
hospital Luxemburg, 29 January 2013.
Godderis L. (2013). Assessing the exposome in occupational cancer. Arbeidshygiëne: van
driewieler tot rotator. Woudschoten Zeist, 17-18 April 2013.
Godderis L, De Raedt K, Tabish A, Hoet P. (2012). Gene-environment interaction in the
induction of epigenetic alterations in workers. International Congress on Occupational
Health. Cancun, Mexico, 18-23 March 2012.
Godderis L, De Raedt K, Tabish A, Maertens N, Bulterys S, Viaene M, Viaene M. (2012).
Do epigenetic changes play a role in the development of chronic toxic encephalopathy?.
International Congress on Occupational Health. Cancun, Mexico, 18-23 March 2012.
Godderis L, De Raedt K, Tabish A, Poels K, Maertens N, De Ruyck K, Bulterys S,
Thierens H, Viaene M. (2011). Epigenetic alterations induced by solvents. 41st European
Mutagen Annual Meeting. Barcelona, 4-7 July 2011.
Godderis L. (2010). Epigenetic Effects in Workers Exposed to Carcinogenic Agents.
Epicoh-Medichem Conference. Taipei (Taiwan), 20-25 April 2010.
Godderis L. (2012). The characterization of the exposome and its impact on cancer.
Occupational Toxicology - Worker Safety and (Geno)toxicity Considerations. Beerse
(Belgium), 23 November 2012.
Godderis L. (2012). How to determine the exposome and its impact on human disease.
Biomonitoring of air quality. Antwerpen, 12- 14 November 2012.
Godderis L. (2012). Voorstelling van de visienota voor de toekomst van de
arbeidsgeneeskunde in België. 51ste Interprovinciaal Congres Welzijn op het Werk. 51ste
Interprovinciaal Congres Welzijn op het Werk. Hotel Stiemerheide Genk, 11 May 2012.
Kuuliala O. Occupational allergic dermatitis from oxidized D-limonene [abstract]. Contact
Dermatitis. 2012;66 Suppl 2S48. 11th Congress of the European Society of Contact
Dermatitis (ESCD), 13–16 June 2012, Malmö, Sweden
Lenderink A. Occupational physicians’ views on barriers and facilitators in occupational
disease reporting in the Netherlands, 30th ICOH Congress Cancun 2012
Lucas Luijckx NB, Van de Brug FJ, Cnossen HJ, Houben GF, Tielemans E. Emerging Risk
Identification - The case of food safety and occupational health. Presentation at the 5th
iNTeg-Risk congress held in Stuttgart (Germany), 21-22 May 2013.
Mattioli S, Gori D, Di Gregori V, Farioli A, Pia Fantini M, Christiani D, Curti S, Violante F.
0408 PubMed search strings for the study of putative environmental determinants of
disease. Occup Environ Med. 2014 Jun;71 Suppl (EPICOH 2014 Chicago Proceedings)
Mattioli S. Diagnostic criteria, Data & Statistics. Occupational Diseases in the EU - The
system(s) and their role / Way forward. EU commission’s launched Conference
“Occupational Diseases in the EU, The system(s) and their role, “together for disease-free
workers”, Brussels, 3rd & 4th December 2013.
Mattioli S, Sauni R, Spreeuwers D, De Schryver A, Valenty M, Rivière S, Curti S.
Interventions for reducing the underreporting of occupational diseases –Minisymposium
'Improving the impact of occupational disease surveillance'. 23rd International Conference
on Epidemiology in Occupational Health. EPICOH 2013. Utrecht, 18-21 June 2013.
Abstracts book, n. 277.
Mattioli S, Delaj L, Gori D, Baldasseroni A, Ricotta L, Curti S, Farioli A, Zanardi F, Violante
FS. Evidence-based search strings for the study of farmers’ occupational diseases. 22nd
International Conference on Epidemiology in Occupational Health. EPICOH 2011. Oxford,
UK, 7-9 September 2011. Abstracts book, p. 106.
Mattioli S, Gori D, Di Gregori V, Ricotta L, Baldasseroni A, Colosio C, Galletti S, Curti S,
Farioli A, Zanardi F, Violante FS. Evidence-based search strings for the study of farmers’
occupational diseases. The IEA-EEF Congress of Epidemiology 2012: Epidemiology for a
Fair and Healthy Society. Porto, 5-8 September 2012. Eur J Epidemiol. 2012;27(Suppl
1):S98.
Mattioli S, Baldasseroni A, Curti S, Zanardi F, Cooke R, Farioli A, Violante F, Coggon D.
Incidence rates of surgically treated rhegmatogenous retinal detachment in manual
workers, non-manual workers and housewives of Tuscany, Italy. International Congress on
Tracing New Occupational Diseases. Amsterdam, 7-8 April 2011. Abstracts book, n. 08.
Mattioli S, De Fazio R, Buiatti E, Truffelli D, Zanardi F, Miglietta B, Curti S, Baldasseroni A,
Tassinari G, Violante F. Relevance of repeated lifting tasks and high body weight in retinal
detachment: results of a case-control study in myopics. International Congress on Tracing
New Occupational Diseases. Amsterdam, 7-8 April 2011. Abstracts book, n. 06.
Mattioli S, Zanardi F, Apostoli P, Semeraro F, Curti S, Farioli A, Baldasseroni A, Violante
FS. Stringhe di ricerca per lo studio di determinanti professionali di malattia: un esempio di
utilizzo pratico [Search strings for study of putative occupational determinants of disease:
an example for practice]. 73° Congresso Nazionale SIMLII. Roma, 1-4 dicembre 2010. G
Ital Med Lav Erg 2010; 32(Suppl 2):191-2.
Mattioli S, Baldasseroni A, Curti S, Zanardi F, Cooke RMT, Farioli A, Violante FS, Coggon
D. Incidence rates of surgically treated rhegmatogenous retinal detachment in manual
workers, non-manual workers and housewives of Tuscany, Italy. XXXIV Congresso
dell’Associazione Italiana di Epidemiologia. L’epidemiologia e la sanità pubblica
nell’Europa che cambia. Firenze, 9 novembre 2010. Abstracts Book, p. 210.
Mattioli S, Zanardi F, Baldasseroni A, Schaafsma F, Cooke RMT, Mancini G, Fierro M,
Santangelo C, Farioli A, Fucksia S, Curti S, Violante FS, Verbeek J. Search strings for
study of putative occupational determinants of disease. International Congress on Rural
Health in Mediterranean and Balkan Countries. Rural Health 2010. Tirana, 22-25
September 2010. Abstracts book, pp. 100-1.
Mehlum IS, Gravseth HM. Registry of outpatients examined by the Norwegian
occupational medicine departments. Abstract for ICOHSCOM (International Congress on
Tracing New Occupational Diseases) 2011 in Amsterdam, April 2011.
McNamee R. Dec 2013. Trends over time in incidence of selected Occupational Diseases
in the EU (2000-2012). EU Commission conference on occupational diseases. December
2013
Mylle G, Godderis L, Verbeke G. (2012). The impact of occupational noise exposure on
blood pressure. International Congress on Occupational Health. Cancun, 18-23 March
2012.
Nakládalová M, Ehler E, Pelclová D, Urban P, Hlávková J, Ridzoň P, Fenclová Z, Richter
M. Spine Disorders as an Occupational Disease (in Czech). 27th Czech and Slovak
Congress of Neurology and Danube Symposium 2013. Praha, 20. – 23. 11 2013. Česk.
Slov. Neurol. 2013, 76/109, Suppl. 2, 44-45
Pal TM. Health surveillance at the production of a new synthetic fiber. The Aramid
experience. International workshop Nanolinen. Berlin May 2011 (Relevant to Modernet
agenda but not based on Modernet Collaboration)
Pal TM. New work-related risks and then? ( Nieuwe arbeidsrisico’s en dan?). Meeting
Contact Group Chemistry ( Contact Groep Chemie). ‘s Hertogenbosch The Netherlands
March 2010. (Relevant to Modernet agenda but not based on Modernet Collaboration)
Pelclová D, Zavadilová A, Fenclová Z, Urban P. Update of Czech List of Occupational
Diseases, does it reflect the reality? Poster at the 30th International Congress on
Occupational Health ICOH, 18-23 March 2012, Cancun, Mexico
Pesonen M. Allergies to protective gloves [abstract]. Contact Dermatitis. 2012;66 Suppl
2S24. 11th Congress of the European Society of Contact Dermatitis (ESCD), 13–16 June
2012, Malmö, Sweden
Pongprueksa P, Van Landuyt K, Janssens H, De Munck J, Godderis L, Van Meerbeek B.
(2013). Effect of photo-initiators on elution and conversion of adhesives. CED-IADR 2013.
Florence, Italy, 4-7 September 2013, Abstract No.S0019.
Rivière S, Chevalier A, Penven E, Cadéac-Birman H, Roquelaure Y, Valenty M.
Estimation of underreporting of musculoskeletal diseases (MSDs) in France. International
Congress on Occupational Health, Mexico 2012
Rivière S, Chevalier A, Penven E, Cadéac-Birman H, Roquelaure Y, Valenty V. Estimation
of under-reporting of work-related musculoskeletal diseases (MSDs) in France. 22nd
International Conference on Epidemiology in Occupational Health. EPICOH 2011. Oxford,
UK, 7-9 September 2011.
Santonen T. Occupational cancer burden – approaches to diagnosis and prevention. EU
commission’s launched Conference “Occupational Diseases in the EU, The system(s) and
their role, “together for disease-free workers”, Brussels, 3rd & 4th December 2013
Suomela S. Incidence of work-related dermatitis in Finland during 2005-2009 [abstract].
Contact Dermatitis. 2012;66 Suppl 2S24. 11th Congress of the European Society of
Contact Dermatitis (ESCD), 13–16 June 2012, Malmö, Sweden
Tabish A, Verwilst J, Hoet P, Godderis L. (2011). Genetic and Epigenetic Effects of Mobile
Phone Radiation. Trends in Metals Toxicity and Ecotoxicity. Mechelen, 8 December 2011.
Vandenbroeck S, Moerenhout E, Sercu M, De Man H, De Witte H, Vanbelle E, Godderis L.
(2013). Burnout a substantial problem in hospital physicians: a multicenter study on its
prevalence, determinants and consequences in 37 Belgian hospitals. Epicoh Conference:
"improving the impact". Utrecht, 18-21 June 2013.
Van der Laan G. 22 september 2010. Tirana ICOH SC rural health Conference. Tracing
New Occupational Diseases in Agriculture
Van der Laan G. 2 februari 2011. Lucknow, India. Congress Safe Use of Nanomaterials
(SUN 2011). Tracing New Occupational Diseases in Nano-workers
Van der Laan G. 7 april 2011, AMC Amsterdam ICOHSCOM Congres. Tracing New
Occupational Diseases, an introduction to the theme
Van der Laan G. 19 oktober 2011. Porto, Portugal. International Congress on Biomarkers
and Human Exposure to Nanoparticles. Medical surveillance of nanoworkers, an early
warning system?
Van der Laan G. 19 maart 2012. Cancun, Mexico. International Conference on
Occupational Diseases (ICOH) Tracing New Occupational Diseases.
Van der Laan G. 28 august 2012. Ystad, Sweden. Nordic Meeting on OHS in Agriculture.
Tracing new occupational diseases in agriculture.
Van der Laan G. 4 september 2013. Brescia, Italy. Summer School Occupational &
Environmental Medicine. Tracing new occupational diseases; OHS vigilance.
Van der Laan G. 24 september 2013. Vienna, Austria World Congress of Neurology.
Occupational Neurology: from nose to brain (Solvents and Nanomaterials)
Van Landuyt K, Yoshihara K, Geebelen B, De Munck J, Godderis L, Hoet P, Van
Meerbeek B. (2011). Contemporary Composites May Release Nano-dust: vol. 521.
DIV/CED/2011. Theoretical Building of the Semmelweis University, 03-09-2011.
Van Landuyt K, Yoshihara K, Geebelen B, De Munck J, Peumans M, Godderis L, Hoet P,
Van Meerbeek B. (2011). Contemporary composites may release nano-dust. 45th Meeting
of the Continental European Division (CED) of IADR, organized together with the
Scandinavian Division (NOF). Budapest, Hungary, 31 Aug-3 Sept 2011.
Zavadilová A. Progress in the search after new occupational diseases in the Czech
Republic (in Czech). Seminar at the Dept. for Occupational Medicine, 1st Medical School,
Charles University, Prague 22. 3. 2013
Zavadilová A. Detection of New Occupational Diseases in European Countries (in Czech).
Seminar at the Dept. for Occupational Medicine, 1st Medical School, Charles University,
Prague, 22. 6. 2012
4. Presentations / conference precedings directly relevant to the Modernet agenda
AND BASED ON MODERNET collaborations at Modernet meetings
Adams E. Non-specific Interstitial Pneumonia: A case report of a flooring worker exposed
to isocyanate fumes. COST-MODERNET Conference, Leuven, 12-14 June 2012.
Agius R. Occupational diseases-old and new. How can they be traced? Conference
MALPROF system and networks for the monitoring of occupational diseases. CostAuditorium INAIL. Rome, 9 Novembre 2012.
Agius RM, Carder M, Hussey L, Stocks SJ, Money A, Turner S, McNamee R. Triangulated
and targeted data collection. COST-MODERNET Conference, Amsterdam, 7-8 April 2011.
Agius RM, Hussey L, Thorley K, Zarin N. Using health surveillance data for online peerbenchmarking as an educational tool to motivate participation in reporting. COSTMODERNET Conference, Amsterdam, 7-8 April 2011.
Bakker JG. COST : Action StanDerm (TD 1206) and Modernet. Results meeting Berlin
COST-MODERNET Conference, Paris, 16-18 October 2013.
Carder M, McNamee R, Hussey L, Agius RM. Best national estimates of trends in
incidence of occupational and work related disease through multiple reporting schemes.
COST-MODERNET Conference, Amsterdam, 7-8 April 2011.
Le Barbier M. A new national thesaurus on occupational exposures. COST-MODERNET
Conference, Leuven, 12-14 June 2012.
Le Barbier M, Christophe Paris and the rnv3p members. French National Network for
Vigilance and Prevention of Occupational Diseases- New Information system. COSTMODERNET Conference, Paris, 16-18 October 2013.
Bensefa L. Allergic occupational dermatitis in France: major allergens and temporal trends
for period 2001-2009 in the RNV3P (first session). COST-MODERNET Conference,
Leuven, 12-14 June 2012.
Bensefa L. A new cause of occupational asthma induced by Chrysonilia sitophila in
workers exposed to coffee grounds. COST-MODERNET Conference, Leuven, 12-14 June
2012.
Bonneterre V, Bicout DJ, De Gaudemaris R. Application of pharmacovigilance methods in
OHS. COST-MODERNET Conference, Amsterdam, 7-8 April 2011.
Bonneterre V, Ameille J, Telle Lamberton M. Tracing newly occurring occupational
diseases with a sentinel clinical approach: from detection to alert. COST-MODERNET
Conference, Amsterdam, 7-8 April 2011.
Bonneterre V. Searching for new occupational diseases with a dual approach: clinical
watch system and data mining analyses conducted on suitable databases. Conference
MALPROF system and networks for the monitoring of occupational diseases. Auditorium
INAIL. Rome, 9 Novembre 2012.
Bonneterre V, Ameille J, Telle Lamberton M. Tracing newly occurring occupational
diseases with a sentinel clinical approach: from detection to alert. COST-MODERNET
Conference, Amsterdam, 7-8 April 2011.
Bonneterre V, Lacroix M, Focant JF. 3 cases of Non Hodgkin Lymphoma among welders
exposed more than 10 years to a spray containing methylene chloride (dichloromethane).
COST-MODERNET Conference, Amsterdam, 7-8 April 2011.
Bonneterre V, Charles J, Salameire D, Bourrain JL, Templier I, Beani JC, Leccia MT.
Case-report: precancerous and cancerous skin lesions limited to area in contact with
epoxy resin in a man applying epoxy resin on floors. COST-MODERNET Conference,
Amsterdam, 7-8 April 2011.
Bonneterre V, Pradat PF, Buisson C, Lagrange E, Bicout D, Boumediene F, Catinon M,
Corona C, Elbaz A, Garnier R and the French collaborative network for ALS clusters
detection and investigation. Occupational and Environmental clusters of Amyotrophic
Lateral Sclerosis (ALS) with exposure to metals polishing dusts. COST-MODERNET
Conference, Amsterdam, 7-8 April 2011.
Bonneterre V, Bon F, Bru JP, Bland S. A case of pulmonary infection to Mycobacterium
fortuitum in a house painter involved in water-damaged buildings remediation. COSTMODERNET Conference, Amsterdam, 7-8 April 2011.
Bonneterre V, Persoons R, Hamm B, de Gaudemaris R. Extrinsic Allergic Alveolitis in a
manicurist with ethyl methacrylate: first case report. COST-MODERNET Conference,
Amsterdam, 7-8 April 2011.
Bonneterre V, Gallot C, Bicout DJ, de Gaudemaris R, on behalf of the RNV3P. Could
Geographic Information Systems (GIS) be of interest for analysing the data of our
occupational diseases surveillance scheme (ODSS)? Example with RNV3P. Part I :
Numerator and Denominator assessment. COST-MODERNET Conference, Manchester,
22-24 November 2011
Brandi G, Di Girolamo S, Farioli A, de Rosa F, Curti S, Pinna AD, Ercolani G, Violante FS,
Biasco G, Mattioli S. Findings from an explorative case-control analysis on the association
between occupational exposure to asbestos and cholangiocarcinoma risk. COSTMODERNET Conference, Manchester, 22-24 November 2011
Carder M. Voluntary medical reporting of work-related illness in the Republic of Ireland:
the challenges of reporting and UK data comparisons. COST-MODERNET Conference,
Leuven, 12-14 June 2012.
Carder M, Bensefa L, Estikova E, Mattioli S, Noone P, Rivière S, Samant Y, Sludds K,
Telle-Lamberton M, Valenty M, Wannag A. EU existing systems recording OD/WRD.
COST-MODERNET Conference, Paris, 16-18 October 2013.
Cocco P. Lymphoma as an occupational diseases. COST-MODERNET Conference,
Bucharest 29–31 May 2013
Cocco P, Silke Kleefeld. Advances in the retrospective assessment of occupational
exposures: results from the multicentre European case-control study Epilymph. COSTMODERNET Conference, Manchester, 22-24 November 2011
Cocco P. Role of occupational exposures in the etiology of non-Hodgkin lymphoma: recent
findings from the Epilymph and Interlymph studies. COST-MODERNET Meeting,
Bucharest, 29-31 May 2013
Colosio C. Exposure and risk profiles for retrospective pesticide exposure assessment in
epidemiological studies. COST-MODERNET Conference, Leuven, 12-14 June 2012.
Colosio C. Special issue Occupational
Conference, Paris, 16-18 October 2013.
Medicine
(London).
COST-MODERNET
Costa David J. EU Commission and OD/WRD; issues and progress of December
conference on OD. COST-MODERNET Conference, Paris, 16-18 October 2013.
Cnossen HJ, Van de Brug FJ, Voogd E, Spaan S, Tielemans E. Early signals for emerging
risks in occupational safety and health. COST-MODERNET Conference, Paris, 16-18
October 2013..
De Schryver A, Van Winckel M, Van Hooste W, Wullepit G, Cornelis K, Charlier A,
Colemonts K. Helicobacter pylori in healthcare workers: a new occupational infection?
COST-MODERNET Conference, Manchester, 22-24 November 2011.
De Schryver A. Reporting and registration of occupational diseases in Belgium – an
overview. COST-MODERNET Conference, Leuven, 12-14 June 2012.
De Vocht F, Kromhout H, Van Tongeren M, Cherrie J, Tielemans E, Agius R. Role of
occupational hygiene/exposure assessment. COST-MODERNET Conference, Paris, 1618 October 2013..
Faye S. Applying count data models to visualize temporal trends in the rnv3p network.
COST-MODERNET Conference, Bucharest 29–31 May 2013
Faye S, Le Barbier M, Delaunay M, Telle-Lamberton M. Paris area’s Occupational Disease
centres and the RNV3P members. COST-MODERNET Conference, Paris, 16-18 October
2013.
Faye S. Indicators of data quality for health databases: the example of the rnv3p network.
COST-MODERNET Conference, Bucharest 29–31 May 2013
Forman SD, Turner S, McNamee R, Carder M, Agius R. Investigating the attribution of
work to Skin Cancer case reporting to The Health and Occupation research (THOR)
network. COST-MODERNET Conference, Manchester, 22-24 November 2011.
Gallagher F, Carder M, Money A, Hussey L, Turner S, McNamee R, Agius R.
Development of guidance for reporting cases to work related ill health surveillance
schemes. COST-MODERNET Conference, Manchester, 22-24 November 2011.
Godderis L, Schouteden M, Mylle G, Vandenbroek S. Precube: data warehouse for
detection and evaluation of trends of occupational diseases. COST-MODERNET
Conference, Bucharest 29–31 May 2013.
Godderis L, Mylle G, Vandenbroek S. Precube: a data warehouse for the detection and
evaluation of trends of occupational diseases. COST-MODERNET Conference, Leuven,
12-14 June 2012.
Godderis L, Vandenbroek S, Faisandier L, Bonneterre V. (2011). Detection of emerging
diseases in occupational health. COST-MODERNET Conference, Manchester, 22-24
November 2011.
Hussey L, Turner S, McNamee R, Agius R. Work-related ill-health reporting from General
Practice-illuminating the blind spot. COST-MODERNET Conference, Manchester, 22-24
November 2011.
Hussey L, Turner S, McNamee R, Agius R. Calculating incidence rates of work-related illhealth from General Practice – establishing the THOR-GP denominator. COSTMODERNET Conference, Manchester, 22-24 November 2011.
Hussey L. Using multiple data sources to triangulate work-related ill-health incidence
estimates. COST-MODERNET Conference, Leuven, 12-14 June 2012.
Lenderink A, Braam I, Moeijes F, Van der Molen H, Smits P, Kuijer P, Bakker J,
Sorgdrager B, Spreeuwers D. Occupational physicians’ views on barriers and facilitators in
occupational disease reporting in the Netherlands. COST-MODERNET Conference,
Manchester, 22-24 November 2011.
Lenderink A. Review on the validity of self-report to measure work-related illness. COSTMODERNET Conference, Amsterdam, 7-8 April 2011
Lenderink A. SIGNAAL: COST-MODERNET Conference, Bucharest 29–31 May 2013
Luzati A. Presenting the national asbestos-related policy in Albania. COST-MODERNET
Conference, Bucharest 29–31 May 2013
Mattioli S. Could Occupational Exposure to n-Hexane and Other Solvents Precipitate
Visual Failure in Leber Hereditary Optic Neuropathy. COST-MODERNET Conference,
Leuven, 12-14 June 2012.
McNamee R, Chen Y, Hussey L, Agius R. Reporting frequency and behaviour in voluntary
surveillance schemes. COST-MODERNET Conference, Manchester, 22-24 November
2011.
McNamee R. Influence of ‘zero case’ reports when estimating incidence and trends in
work-related (WR) disease. An investigation in the GB EPIDERM scheme 1996-2010.
COST-MODERNET Conference, Leuven, 12-14 June 2012.
McNamee R. Using surveillance data to describe national trends and evaluate
interventions. Conference MALPROF system and networks for the monitoring of
occupational diseases. Auditorium INAIL. Rome, 9 Novembre 2012.
McNamee R. New issues emerging from WG2 work Cost Modernet Conference, Paris,
France, 16-18 October 2013.
McNamee R. Design of studies to evaluate effect of national interventions to reduce workrelated diseases. COST-MODERNET Conference, Zaragoza 9-11 April 2014.
McNamee R. Influence of ‘zero cases’ reports when estimating time trends in Workrelated Disease: new results. COST-MODERNET Conference, Zaragoza 9-11 April 2014.
Miller P. Role of Health Economics. COST-MODERNET Conference, Paris, 16-18 October
2013.
Mylle G. The impact of occupational noise exposure on blood pressure. COSTMODERNET Conference, Leuven, 12-14 June 2012.
Nerrière-Catelinois. Use of adjusted ROR as association indicators between diseases and
activity sectors on rnv3p data from OD centres and occupational health services. COSTMODERNET Conference, Leuven, 12-14 June 2012.
Palmen N. Emerging Risk Identification Support service (ERIS) that identifies new and
unexpected hazards and helps stakeholders make well-considered decisions at an early
stage. COST-MODERNET Conference, Bucharest 29–31 May 2013
Papale/Campo. Cervical hernia: occupational disease? COST-MODERNET Conference,
Bucharest 29–31 May 2013
Pelclová D, Nakládalová M, Urban P, Ridzoň P, Hlávková J, Fenclová Z, Ehler E,
Richter M, Zavadilová A. Development of an objective method for quantification of the
etiologic fraction of the occupational risk factors in the chronic lumbar vertebral column
diseases – Presentation of a Project IGA. Paříž: COST-MODERNET Conference, Paris,
16-18 October 2013.
Pilorget C. Classifications of occupations and economic activities used in MODERNET.
COST-MODERNET Conference, Paris, 16-18 October 2013.
Pranjić N, Dedić S. Occupational lung cancer risk in Tuzla Canton, Bosnia and
Herzegovina. COST-MODERNET Conference, Manchester, 22-24 November 2011
Pranjic N. Presenteeism and consequences of presenteeism to health and work
performances among primary health care workers with indirect costs following Levi exact
assessment. COST-MODERNET Conference, Bucharest 29–31 May 2013
Rempel D. A presentation on Upper Limb disorders. COST-MODERNET Conference,
Bucharest 29–31 May 2013
Rieutort D. Observational Surveillance of Occupational Health Problems. COSTMODERNET Conference, Bucharest 29–31 May 2013
Rivière S, Chevalier A, Penven E, Cadeac-Birman H, Roquelaure Y, Valenty M. Underreporting of work-related musculoskeletal diseases (MSDs) in France. COST-MODERNET
Conference, Manchester, 22-24 November 2011
Seed M, Agius RM. Iteration and evaluation of Quantitative Structure Activity Relationships
to identify novel occupational allergens. International Congress on Tracing New
Occupational Diseases: methodology, recent findings and implications for OHS policy.
Amsterdam, 7,8 April 2011.
Seed M, Agius R. Using Quantitative Structure Activity Relationships to help corroborate
sentinel case reports of occupational respiratory disease. COST-MODERNET Conference,
Manchester, 22-24 November 2011
Schneider E. EU-OSHA perspective on recognising new hazards and risks and workrelated diseases Cost. COST-MODERNET Conference, Paris, 16-18 October 2013.
Spreeuwers D. The current situation of occupational diseases systems in Europe, in
particular relative to Commission Recommendation 2003/670/EC COST-MODERNET
meeting. COST-MODERNET Conference, Manchester, 22-24 November 2011
Stocks SJ, Turner S, McNamee R, Carder M, Agius R. Evaluating interventions to reduce
allergic contact dermatitis due to occupational latex and chromate exposure. COSTMODERNET Conference, Amsterdam, 7-8 April 2011.
Stocks SJ, Carder M, Agius R. Evaluating the impact of health and safety interventions
and market forces on the incidence of work-related asthma. COST-MODERNET
Conference, Manchester, 22-24 November 2011
Stocks SJ, Carder M, Agius R. Using standardised incidence rate ratios to identify
occupations and industries at increased risk of medically-reported work-related ill-health.
COST-MODERNET meeting. COST-MODERNET Conference, Manchester, 22-24
November 2011
Stocks SJ. Changes in the incidence of short latency work-related respiratory disease
concurrent with changes in legislation for workplace exposure limits. COST-MODERNET
Conference, Leuven, 12-14 June 2012.
Stocks SJ. Results of survey: trends in allergic contact dermatitis and the chromate
directive. COST-MODERNET Conference, Bucharest 29–31 May 2013
Stocks SJ and McNamee R. Trends in incidence of some WRD across EU participating
countries. COST-MODERNET Conference, Paris, 16-18 October 2013.
Stocks SJ and WG2 collaborators. A comparison of trends in incidence of occupational
diseases across 10 European Countries (2000-2012). COST-MODERNET Conference,
Zaragoza, 9-11 April 2014
Telle-Lamberton M, Paris C, Bensefa-Colas L, Faye S, Larabi L, Le Barbier M, Lasfargues
G, Luc A, Ngatchou-Wandji J, and the RNV3P members. Trends in work related diseases
in France between 2001 and 2009: examples of contributions from the French National
Network for Vigilance and Prevention of Occupational Diseases. COST-MODERNET
Conference, Manchester, 22-24 November 2011
Urban P, Fenclová Z, Bittner Z, Zavadilová A. Occupational Diseases in the Czech
Republic in 2012. COST-MODERNET Conference, Bucharest 29–31 May 2013
Urban P, Fenclová Z, Zavadilová A, Pelclová D. Occupational Diseases in the Czech
Republic in 2011. COST-MODERNET Conference, Leuven, 12-14 June 2012
Urban P, Bittner Z. How Can Czech Republic Contribute to the MODERNET? COSTMODERNET Conference, Amsterdam, 7-8 April 2011
Urban P, Zavadilová A, Pelclová D. Latest Developments Concerning the Czech List of
Occupational Diseases. COST-MODERNET Conference, Manchester, 22-24 November
2011
Valenty M, Boutou-Kempf O, Jarchand J, Imbernon E. The French national
epidemiological surveillance system of nanoworkers. COST-MODERNET Conference,
Manchester, 22-24 November 2011
Van der Laan G. Reconstructing the EU Recommendation on Occupational Diseases?
COST-MODERNET Conference, Leuven. 12-14 June 2012.
Van der Laan G, Pal T, Van Broekhuijzen P. An early warning system for workers with
Nanomaterials? COST-MODERNET Conference, Manchester, 22-24 November 2011
Van der Laan G. A case of Leu-enkephalin intoxication? COST-MODERNET meeting.
COST-MODERNET Conference, Manchester, 22-24 November 2011
Van der Laan G. Progress report. COST-MODERNET Conference, Bucharest 29–31 May
2013
Van der Molen H. Interrupted time series for evaluation of preventive interventions? experiences from a review on injuries in construction work. COST-MODERNET
Conference, Bucharest 29–31 May 2013
Van der Molen H. Facilitators for prevention of occupational diseases -A qualitative study.
COST-MODERNET Conference, Bucharest 29–31 May 2013
Wannag A. Coding systems. Changing the general practitioners ICPC disease codes to
the ICD-10 system. Easier use of exposure codes. COST-MODERNET Conference,
Manchester, 22-24 November 2011.
Zavadilová A: NEEDS and BARRIERS in tracing new occupational diseases and data
collection in the Czech Republic. COST-MODERNET Conference, Leuven, 12-14 June
2012