PRELIMINARY PROGRAM BIOTECHNOLOGY AND MEDICINE M OSCOW I NTERNATIONAL CONFERENCE March 14-17, 2006 Co-Chairmen: Aleksei M. Egorov, Professor, Academician of the RAMS, Anatoly I. Miroshnikov, Professor, Academician of the RAS Tuesday, March, 14, 2006 LARGE CONFERENCE-HALL (10.00-13.30) 9.30-10.30 Opening Ceremony Plenary session «FUNDAMENTAL RESEARCHES AND BIOTECHNOLOGY » Chairman: Vadim T. Ivanov, Professor, Academician of the RAS, Director of the Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry of the RAS; Daniel Thomas, Professor, UMR CNRS, Génie Enzymatique et Cellulaire, Université de Technologie de Compiègne, France 10.30-10.40 G r e e t i n g s p e e c h V.T. Ivanov, Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry, RAS, Moscow Sectional Reports: 14.30-14.55 “Immunoliposomes as the Carriers of Anticancer Drugs”. A. Yu. Baryshnikov, N. A. Oborotova, Ye. V. Tolcheva; N. N. Blokhin Oncological Research Center, RAMS, Moscow, Russia 14.55-15.15 “Vaccine Therapy of Cancer”. I. N. Mikhailova, A. Yu. Baryshnikov; N. N. Blokhin Oncological Research Center, RAMS, Moscow, Russia 15.15-15. 35 “Immune Prophylaxis of Oncological Diseases Through Xenigenic Cells”. S. E. Severin; All-Russia Research Center of Molecular Diagnostics & Therapy 15.35-15.55 “Soluble Forms of Differentiation Antigenes in Immune Monitoring of the Tumor Growth”. V. V. Novikov;, Research Institute of Molecular Biology & Regionar Ecology of the N. I. Lobachevsky State University; Nizhny Novgorod, Russia 16.00-16.15 COFFEE BREAK PLENARY LECTURE 16.15-16.35 “Monoclonal Antibodies in Tumor 10.40-11.20 “Systems Biology — an Interdisciplinary Diagnostics & Therapy”. V.I. Chisov, R. I. Yakubovskaya; P. A. Gertsen Moscow Research Oncological Institute, Moscow, Russia 16.35-16.55 “Clinical Study of ATEMA – the First Russian Therapeutic Agent Based on Monoclonal Antibodies to CD-antigen of Human T-lymphocytes” P.K. Ivanov,1 E.F. Chmutin,1 D.V. Perlin,2 A.S. Sokolsky,3 et al. , 1N. Blokhin Memorial Cancer Research Center, 2 Moscow municipal Approach in Biomedicine”. Daniel Thomas, UMR CNRS, Génie Enzymatique et Cellulaire, Université de Technologie de Compiègne, France 11.20-12.00 “Nanotechnologies and Medicine”.∙ Alexander I. Archakov, Institute of Biomedical Chemistry of the RAMS 12.00-12.20 COFFEE BREAK 12.20-13.00 “Problems of Genotherapy of Cancer”. Georgy P. Georgiev, Institute of Gene Biology of the RAS 13.00-13.40 “Telomerase as Object for Biomedical Researches”. Aleksei A. Bogdanov, O.A. Dontsova, M.V. Lomonosov Moscow State University Tuesday, March, 14, 2006 LARGE CONFERENCE-HALL (14.00-18.30) Section 2.1. ONCOLOGY Co-Chairmen: Georgy P. Georgiev, Professor, Academician of the RAS, Director of the Institute of Gene Biology of the RAS; Anatoly Yu. Baryshnikov, Professor, Director of the Research Institute of Experimental Diagnostics & Tumor Therapy of the Russian Oncology Scientific Center Plenary Report: 14.00-14.30 “Multifunctional Pharmaceutical Nanocarriers for Tumor Targeting”. V. Torchilin; Department of Pharmaceutical Sciences, Northeastern University, Boston, USA hospital №7, 3Research Institute of Urology of the Russian Ministry of Health and Social Development, Russia 16.55-17.15 “Present Possibilities of Application of Cytokins in Oncology”. Z. G. Kadagidze; N.N. Blokhin Oncological Research Center, RAMS, Moscow, Russia 17.15-17.35 “Gene Engineering Approaches to Antiangiogenic Therapy”. S. S. Larin, Institute of Gene Biology, RAS, Moscow, Russia 17.35-18.15 “Perspectives of Antiangiogenic Therapy in Oncology”. Ye.V. Stepanova; N. N. Blokhin Oncological Research Center, RAMS, Moscow, Russia 18.15-18.35 “Biochip-Based Testing Systems for Diagnostics of the Prostate Cancer”. T. V. Osipova1, T. V. Riabykh1, Ye. I. Dementieva2, A. Yu. Rubina2; 1 N.N. Blokhin of the Russian Oncological Scientific Center, RAMS, Russia; 2 Engelhardt Institute of Molecular Biology, RAS, Russia Tuesday, March, 14, 2006 17.55-18.15 “Molecular Targets for Pharmacological Intervention f Alzheimer’s Disease”. S.O. Bachurin, Institute of Physiologically Active Compounds, RAS, Russia SMALL CONFERENCE HALL (14.30-18.30) Section 2.7. NEYRO-PSYCHOTHERAPY Co-Chairmen: Vladimir P. Chekhonin, Professor, Academician of the RAMS, Head of the Biology Psychotherapy Departament of the V.P. Serbsky State Scientific Center; Sergey O. Bachurin, Professor, Corresponding Member of the RAS, Deputy Director of the Institute of Physiologically Active Substances of the RAS Tuesday, March, 14, 2006 SECTOR A CONFERENCE HALL (14.00-18.00) Section 2.3. IMMUNOBIOTECHNOLOGY (VACCINES, IMMUNOMODULATORS, ALLERGOLOGY) Co-Chairmen: Plenary Report: 14.30-15.00 “Monoamine Synthesis by Non- Monoaminergic Neurons is a New Mechanism of the Brain Plasticity in Neurodegenerative Disorders” M.V. Ugriumov, Koltzov Institute of Developmental Biology, RAS, Institute of Normal Physiology RAMS, Moscow, Russia Sectional Reports: 15.00-15.25 “Directed Transportation of Nanoparticles Into the Brain”. R.N. Aleutdin; M. Sechenov Мoscow Мedical Аcademy, Moscow, Russia 15.25-15.50 “Directed Transportation of Biologically Active Substances Through Haematoencephalitic Barrier”. Y. Zhang, W. M. Pardridge; UCLA, Los Angeles, USA 15.50-16.15 “Neurochemical Correction of Prenatal Damages of a Rats’ Brain by the Short Strand Peptides”. M. G. Uzbekov; P.P. Ghannushkin Moscow Institute of Psychiatry, Moscow, Russia 16.15-16.30 COFFEE BREAK 16.30-16.55 “Targeted Transport of the PEGilated Immunoliposomes to the Brain Astrocytes” V. P. Chekhonin*, Yu. A. Zhirkov, O. I. Gurina, T. B. Dmitrieva, Laboratory of Immunochemistry, Serbsky National Research Center for Social and Forensic Psychiatry, Russia 16.55-17.15 “Biologically Active Peptides in the Complex Therapy of Ischemic Stroke” V.I. Skvortsova, Department of Fundamental and Clinical Neurology, Russian State Medical University, Moscow 17.15-17.35 “Perspectives of Usage of Immunomodulators in a Complex Therapy of the Border Mental Disorders”. Yu.A. Alexandrovsky, O.L. Palko, T.V. Kulikova; Russian Center for the Border Psychiatry, Moscow, Russia 17.35-17.55 “Biologically Active Preparation in the Medical Treatment of Demyelinizing Diseases”. A.N. Boiko, E.I. Gusev, O.O. Favorova; Russian State Medical University, Moscow Rem V. Petrov, Professor, Academician of the RAS, Head of the Department of Immunobiotechnology, Research Center of Immunology Institute; S.V. Komisarenko, Professor, Academician of National Academy of Sciences Director of the O.V. Paladin Institute of Biochemistry of the National Academy of Sciences of Ukraine, Kiev 14.00-14.25 “VICHREPOL – First Russian antiHIV/AIDS Vaccine” I.G. Sidorovich, I. A. Nikolayeva , G.O. Gudima, E. V. Karamov et al., 1 Institute of Immunology, FMBA, Russia 14.25-14.50 “Anti-Smallpox Vaccine Based on a Cell Cultivated Virus”. Ye.V. Pimenov; Viatsky State University, Kirov, Russia 14.50-15.15 “Allergtropines as New Preparations for Allergy Treatment”. P.V. Petrov, R.M. Khaitov, A.V. Nekrasov, V.N. Fedoseeva, N.I. ljina, A.I. Martynov, National Research Center Institute of Immunology, Moscow, Russia 15.15-15.40 “New Generation of Recombinant Immunotoxins”. S. M. Deyev; Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry, RAS, Russia 15.40-16.00 COFFEE BREAK 16.00-16.25 “Catalytic Antibodies toword Biopolymers: Biochemistry, Immunology, Pathology” Alexander Gabibov, Shemyakin&Ovchinnikov Institute of Bioorganic Chemistry, RAS, Moscow 16.25-16.50 “Chemokines in Immunotherapy”. A. A. Totolyan; I. A. Pavlov State Medical University, Federal Center for Molecular Medicine, St. Petersburg 16.50-17.15 “Perspectives of Biological Modifiers in Autoimmune Disease” E.L. Nasonov, G.V. Lukina, State Institute of Rheumatology, RAMS, Russia 17.15-17.35 “Present State and Perspectives for Production of Immunobiological Preparations in Russia”. Anton V. Katlinsky, NPO “Microgene”, Russia 17.35-17.55 “CANDIDATE HIV-1 VACCINES ON THE BASIS OF THE VECTOR SYSTEMS INCLUDING ARTIFICIAL GENES, CODING ACTUAL HIV-1 ANTIGENIC DETERMINANTS”. L.I. Karpenko*, S.I. Bazhan, N.A. Nekrasova, L.R. Lebedev et al., The State Research Center of Virology and Biotechnology “Vector”; Koltsovo, Novosibirsk Region, Russia Wednesday , March, 15, 2006 SMALL CONFERENCE HALL (10.00-13.30) Section 2.4. VIROLOGY Co-Chairmen: Sergey V. Netesov, Professor, Corresponding Member of the RAS, Deputy Director of the “VECTOR” State Research Center of Virology & Biotechnology; Vitaly V. Zverev, Professor, Academician of the RAMS, Director of the O.K. Andzhaparidze Research Institute of Viral Medication of the RAMS 10.00-10.25 “Viruses as Objects and Subjects in Biotechnology and Medicine”. S. V. Netesov, FSES State Research Center of Virology and Biotechnology “Vector”, Koltsovo, Novosibirsk Region, Russia 10.25-10.50 “Biodiversity of Influenza Viruses” O.I. Kiselyev, Institute of Influenza, RAMS, St-Petersburg , Russia 10.50-11.15 “The Newest Methods of Diagnostics of Virus Infections» G. A. Shipulin, Central Institute of Epidemiology, Moscow, Russia 11.15-11.35 “The Peculiarities of Clinic and Treatment for Re-emerging Viral Infections” V.V. Maleyev, Central Research Institute of Epidemiology, Moscow, Russia 11.35-11.50 COFFEE BREAK 11.50-12.15 “Perspective of Elimination of Measles and Parotitis” V.V. Zverev, O. K. Andzhaparidze Research Institute of Viral Medication, RAMS, Russia 12.15-12.40 “Problems of Elimination of Poliomyelitis” V.P. Grachev, Institute of Poliomyelitis and Virus Encephalitis named after M.P.Chumakov, RAMS, Moscow, Russia 12.40-13.05 “Questions of Vaccinal Prevention Tickborne Encephalitis in View of the Modern Data on Natural Genetic Variability of the Activator”. V.I. Zlobin, Institute of Poliomyelitis and Virus Encephalitis named after M.P. Chumakov, RAMS, Moscow, Russia 13.05-13.30 “Basic and Applied Studies of Orthopoxviruses Pathogenic for Humans”. S.N. Shchelkunov, FSES State Research Center of Virology and Biotechnology “Vector”, Koltsovo, Novosibirsk region, Russia Wednesday , March, 15, 2006 SMALL CONFERENCE HALL (14.00-17.30) Section 1.1. NANOTECHNOLOGY IN MEDICINE Co-Chairmen: Alexander I. Archakov, Professor, Academician of the RAMS, Director of the Institute of Biomedical Chemistry of the RAMS; Mikhail V. Kovalchuk, Professor, Corresponding Member of the RAS, Director of the Institute of Crystallography of the RAS 14.00-14.30 “Surface-Engineered Nanoparticles as Drug Carriers”. P. Couvreur, R. Gref, France 14.30-14.55 “Nanoparticles in Medical Treatment”. O.M. Ipatova; V. N. Orekhovich Research Institute of Biomedical Chemistry of the RAMS 14.55-15.20 “Nanotechnology in Diagnostics”. Yu.D. Ivanov, T.O. Pleshakova, P.A. Frantsuzov, S.K. Svetlov et al., V.N. Orekhovich Research Institute of Biomedical Chemistry of the RAMS 15.20-15.45 “Nanoscopy Methods and Apparatuses for Biology and Medicine” I.V. Yaminsky, G.A. Kiselev, A.S. Filonov, Moscow State University, Physical and Chemical Departments 15.45-16.00 COFFEE-BREAK 16.00-16.20 “Bio Non-Organic Nanostructures: Fundamental and Applied Aspects”. E.B. Khomutov; M. V. Lomonosov Moscow State University, Russia 16.20-16.50 “Morphological Diversity of Hydroxyapatite Nanodisperse Forms”. V.N. Rudin, I.V. Melikhov, A.M. Egorov, A.V. Severin; Chemical Faculty, M.V. Lomonosov Moscow State University 16.50-17.10 “Nano-electrode arrays for electroanalysis in medicine” Arkady A. Karyakin, Analytical chemistry Dept., Chemistry Faculty of M.V. Lomonosov Moscow State University, Moscow, Russia 17.10-17.30 “The Usage of anotubes in biostimulators for the regulation of biological objects vital activity” Egorov M.A., Astrakhan State University, Astrakhan, Russia Wednesday , March, 15, 2006 PRESIDIUM HALL OF THE LARGE CONFERENCE HALL (14.00-18.40) Section 2.8. GENE THERAPY& ENZYMOTHERAPY Co-Chairmen: Valentin V. Vlasov, Professor, Academician of the RAS, Director of the Institute of Chemical Biology & Fundamental Medicine of the RAS, Novosibirsk; Temirbolat T. Beriozov, Professor, Academician of the RAMS, Professor of the People’s Friendship University of Russia 17.15-17.35 17.35-17.55 14.00-14.20 “Gene Therapy of the Monogenic Hereditary Diseases”. V.S. Baranov, Institute for Obstetrics & Gynecology, St.-Petersburg, Russia 14.20-14.40 “Gene Correction”. V.V. Vlasov, Institute of Chemical Biology & Fundamental Medicine, SB RAS, Novosibirsk, Russia 14.40-15.00 “Small interfering RNAs as potential therapeutics”. E.L. Chernolovskaya, T.O. Kabilova, Е.B. Logashenko, A.V. Vladimirova, V.V. Vlassov, Institute of Chemical Biology & Fundamental Medicine, SB RAS, Novosibirsk 15.00-15.20 “Recombinant Enzymes for Synthesis of Chiral Drugs” V. I. Tishkov; M. V. Lomonosov Moscow State University, Russia 17.55-18.15 18.15-18.35 Wednesday, March, 15, 2006 SECTOR A CONFERENCE HALL 15.20-15.35 COFFEE BREAK (10.00-13.30) 15.35-15.55 “Enzyme Immobilization: from 15.55-16.15 16.15-16.35 16.35-16.55 16.55-17.15 Intramolecular Cross Links towards Conjugates with Monoclonal Antibodies”. E.V. Lukasheva, A.Kh. Keramova, T.T. Berezov; Department of Biochemistry, Russian Peoples’ Friendship University, Moscow, Russia “Glycosaminoglycan Microenvironment of Hyaluronidase in Regulation of Tissue Permeability”. A.V. Maksimenko & E.G. Tischenko, Institute of Experimental Cardiology, Russian Cardiology Research-and-Production Complex, Moscow “Development of Micro- and Nanoparticlate Drug Delivery Systems Prepared by Selfassembling of Polyelectrolytes and Amphiphilic Copolymers”. Larionova N.I.1, Balabushevich N.G.1, Villemson A.L. 1, Gref R.2, Balkina A.S1. 1 Faculty of Chemistry, The M.V. Lomonosov Moscow State University, Russia, 2 Faculty of Pharmacy, University of Paris-Sud XI, France “The ways of realization of enteropeptidase unique specificity”. L.D. Rumsh, V.V. Likhareva, A.G. Mikhailova, Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry RAS, Russia “A Neuroprotective Properties of Agonists of Proteinase - Activated Receptors”. S.M. Strukova, L.R. Gorbacheva, T.P. Storojevykh*, V.G. Pinelis*, The Lomonosov Moscow State University, Department of Human & Animal Physiology, *The Scientific Centre for Children Health, RAMS, Moscow, Russia “The Ways of Thrombolytic Effectiveness Increase of Plasminogen Activators.” R.B. Aisina, Mukhametova L.I., Varfolomeyev S.D., Chemical Enzymology Department., Chemistry Faculty, Lomonosov Moscow State University, Russia “New Application of the Inhibitors of Angiotensin-converting Enzyme in Ophthalmology.” O.A. Kost 1, Chesnokova N.B.2, Makarov P.V.2, Nikolskaya I.I.1 et al., 1Moscow State University, Chemistry Faculty, 2Helmholz Moscow Institute for Eye Diseases, Russia “Enzymes in the Clinical Nutrition. M.M.G. Gapparov, A.V. Vasiliev, State Institute of Nutrition RAMS, Moscow “New textile wound healling material with multyenzyme activity - “Multyferm”. A.A. Belov, V.N. Filatov, E.N. Belova, Research Institute of Textile Materials of the Russian Academy of Engineers; Moscow Section 1.2. BIOINFORMATICS Co-Chairmen: Frank Eisenhaber, Professor, Head of bioinformatics Department, Research Institute of Molecular Pathology, Vienna, Austria; Vladimir V. Poroikov, Professor, Vice-Director of the Institute of Biomedical Chemistry of the RAMS, Russia 10.00-10.30 “Posttranslational Modifications and Subcellular Localization Signals: Prediction From Protein Sequence and Experimental Verification”. Frank Eisenhaber, Research Institute of Molecular Pathology, Vienna, Austria 10.30-11.00 “Bioinformatics: New Abilities for the Biomedical and Biotechnology Information Management based on GRID technology”. Luciano Milanesi, CNR - Institute for Biomedical Technologies, Milan, Italy 11.00-11.30 “On the Nature of Structural and Deleterious Effects of Single Nucleotide Polymorphisms in Globular and Fibrous Proteins”. Vladimir Tumanyan, Institute of Molecular Biology of the RAMS, Moscow, Russia 11.30-11.45 COFFEE BREAK 11.45-12.15 “Promoter Evolution of the Regulatory Genes”. Alexander Kel, BIOBASE GmbH, Wolfenbuettel, Germany 12.15-12.40 “The GPI lipid anchor biosynthesis pathway: Discoveries with computational methods” Birgit Eisenhaber, Institute of Molecular Pathology, Vienna, Austria 12.40-13.05 “Cyclonet - an Integrated Database on Cell Cycle Regulation and Carcinogenesis”. Fiodor Kolpakov, Design Technological Institute of Digital Techniques, Siberian Branch of the RAS; Novosibirsk, Russia 13.05-13.35 “In Silico Generation and Screening of the Virtual Macrolide Libraries”. Vladimir Poroikov, Institute of Biomedical Chemistry of the RAMS; Moscow, Russia Wednesday , March, 15, 2006 SECTOR Б CONFERENCE HALL (14.00-16.00) Section 2.5. CARDIOLOGY Chairman: Vsevolod A. Tkachuk, Professor, Academician of the RAMS, Corresponding Member of the RAS, Dean of the Fundamental Medicine Faculty, M. V. Lomonosov Moscow State University 14.00-14.30 “Technologies of Sorbtion in the Medical 14.30-14.50 Wednesday , March, 15, 2006 14.50-15.10 SECTOR Б CONFERENCE HALL (10.00-13.00) Round-Table Seminar CELLULAR BIOTECHNOLOGY Co-Chairmen: Vladimir N. Yarygin, Professor, Academician of the RAMS, Rector of the Russian State Medical University; Gennady T. Sukhikh, Professor, Academician of the RAMS, Research Center of Obstetrics, Gynecology and Perinatology of the RAMS; Valery G. Savchenko, Professor, Corresponding Member of the RAMS, Hematology Scientific Center of the RAMS “The basic approaches to controlled cell necrosis”. D.I. Tsyganov, Public Corporation " MKNT ", Moscow 15.10-15.30 15.30-15.50 Treatment of Cardio Vascular Diseases”. S. N. Pokrovsky; Russian Cardiology Research Industrial Complex, Ministry of Health of the Russian Federation, Moscow, Russia “Prourokinaza as a New Fibriolytic Preparation”. R. Sh. Bilabishvily; Russian Cardiology Research Industrial Complex, Russia “Gene and Cellular Therapy in Cardiology: Problems and Perspectives”. Ye. V. Parfionova; Russian Cardiology Research Complex, Moscow, Russia “Adipose Stromal Cells Stimulate Angiogenesis”. Tsokolaeva Z.I., Traktuev D.O., N.I. Kalinina., Johnstone B. et al., 1- Faculty of Fundamental Medicine, Moscow Lomonosov State University, Russia, 2- Krannert Institute of Cardiology, Indiana Center for Vascular Biology & Medicine, USA “Thrombin Aptamers: Application to Diagnostics and Therapy” A.M. Kopylov 1,2, V.A. Spiridonova 2, R.V. Reshetnikov 3, A.V. Golovin 3 et al., 1 Chemistry Department, 2Belozersky Institute Physical Chemical Biology, 3Department of Bioengineering and Bioinformatics, Lomonosov Moscow State University, 4Russian Cardiology Research and Production Center, Moscow “Modulation specific immune response by activated autologous dendritic cells in vitro”. Sennikov S.V.1, Zherebtsova N.O.1, Khripko O.P.1, Shevchenko Y.A.1 et al., 1Institute of Clinical Immunology CB RAMS, Novosibirsk, 2MEH TCH №1, 3Novosibirsk institute of Tuberculosis, 4Novosibirsk MICH №1, 5NSMU. “Bone-marrow stem cell application in liver cirrhosis treatment” Chernykh E. R., Starostina N.M., Leplina O.Y., Shevela E.Y. et al. Institute of Clinical Immunology RAMS SB, Novosibirsk, Russia “Multipotent mesenchymal stem cells are perspective material for engineering osteo- and chondrogenesis in vitro”. Teplyashin A.S., Chupikova N.I., Sharifullina S.Z., Savchenkova I.P., et al., Institute of stem cell, Mosсow “Cell hybridization as a possibility to decrease the histocompatibility barrier” Grezina N.M., Klenovitsky P.M., Zinovieva N.A., Ernst L.K. All-Russian State Research Institute of Animal Breeding of the RAAS, Dubrovitsy settlement, Moscow region, Russia. Wednesday , March, 15, 2006 SECTOR Б CONFERENCE HALL (16.15-18.30) Section 2.6. ENDOCRINOLOGY Co-Chairmen: Ivan I. Dedov, Professor, Academician of the RAMS, Director of the Scientific Center of Endocrinology of the RAMS;; Galina A. Melnichenko, Professor, Corresponding Member of the RAMS, Director of the Institute of Clinical Endocrinology, Scientific Center of Endocrinology; Yurii A. Pankov, Professor, Academician of the RAMS, Scientific Center of Endocrinology of the RAMS P LENARY REPORTS: 16.15-16.45 “Perspective Objects for Biotechnological Researches in Endocrinology”. Yu. A. Pankov; Scientific Center of Endocrinology of the RAMS, Russia 16.45-17.15 “New Approaches for Targeting Defective Insulin Secretion”. S.V. Zaitsev; Stockholm, Sweden Sectional Reports: 17.15-17.35 “Biotechnological Methods of Diagnosis and Medical Treatment of Diabetes”. M. I. Balabolkin; Scientific Center of Endocrinology, RAMS, Russia 17.35-17.55 “Molecular Genetics of Deficit of the Hormone of Growth. Modern Methods of Diagnostics and Cure”. O.V. Fofanova, Scientific Center of Endocrinology, RAMS, Russia 17.55-18.15 “Molecular Genetics in Diagnostics of the Diseases Accompanied by Violations in the Formation of Sex”. A. N. Tiulpakov, Scientific Center of Endocrinology, RAMS, Russia 18.15-18.30 “Screening profiling” in Diagnostics of Endocrinology Diseases”. Appolonova S.A., Antidoping Centre, Moscow Wednesday , March, 15, 2006 SECTOR Т CONFERENCE HALL (9.30.00-19.00) Section 3.5. BIOTECHNOLOGY PROCESSES APPARATUSES Chairman: I.A. Dyatlov, Professor, Director of the Research Center for Applied Microbiology and Biotechnology, Moscow, Russia Co-Chairman: Ye.Ye. Katalevsky, PhD, academician of the Academy of Medical-Technical Sciences of the Russian Federation General Director ZAO “Vladisart”, Vladimir, Russia Greeting speech I.A. Dyatlov, Research Center for Applied Microbiology and Biotechnology, , Moscow, Russia 9.40-10.10 “COMPLEX APPROACH TO EQUIPPING 9.30- 9.40 BIOTECHNOLOGICAL INDUSTRY”. Ye.Ye. Katalevsky, ZAO “Vladisart”, Vladimir, Russia BIOTECHNOLOGICAL PROCESSES”. Ye. Ye. Katalevsky, S. P. Saveliev ZAO “Vladisart”, Vladimir, Russia 12.15-12.30 “The Selection of Financial Tools for Realization of Innovational and Commercial Projects for Biotechnology Processes Technique” V.L. Shaposhnikov1, S.P. Saveliev 2, 1 AKB Promsvyazbank, Moscow, Russia, 2 ZAO “Vladisart”, Vladimir, Russia 12.30-12.45 “Application of a Flow Ultra Filtration Method at Manufacturing Associated Inactivated Avian Diseases Vaccines” D.L. Dolgov, V.V. Borisov, FGI “Federal center for animal health” (FGI ARRIAH), Vladimir, Russian Federation 12.45-13.00 “REVIEW OF THE MODERN MARKET OF ENZYMERS AND BIOREACTORS”. M. S. Benevolensky, OOO “TRIS”, Moscow 13.00-13.45 LUNCH 13.45-15.45 “Revealing Hidden Biomarkers' using Intact Protein Partitioning and Fractionation Systems”. Dr. Suresh Gadher, Beckman Coulter, Switzerland 15.45-16.00 COFFEE BREAK 16.00-16.20 “The equipment for Modern Laboratory Technologies”. G.А. Таrasova, Labmetod Ltd., Moscow, Russia 16.20-16.40 “Polyamide membrane microfilter and cartridge filter for sterilizing liquids and virusological water control”. А.V. Таrasov, Yu.А. Fedotov, S.А. Таrasova, Е.S. Yavorskaya*, «Теchnofilter» Ltd, Vladimir, Joint-stock company “Research Institute Medpolymer”, Moscow 16.40-17.00 “Gas-vortex Gradientless Bioreactors - an entirely New Class of Apparatuses for Microbiological Synthesis”. Yu.A. Ramazanov, JSC “Sajany”, Novosibirsk 17.00-17.40 “How to Make Use of the Latest Generation of Analytical Instruments in the Biotechnology Industry”. Graham Lewis, Ametek Process & Analytical Instruments, Meerbusch, Germany 17.40-18.10 COFFEE BREAK 18.10-18.40 Discussion `Thursday, March, 16, 2006 SMALL CONFERENCE HALL (10.00-13.30) 10.10-11.10 “BIOTECHNOLOGICAL PROCESSES’ SOLUTIONS USING SARTORIUS AG EQUIPMENT AND MATERIALS”. D. Szarafinski , «Sartorius AG», Germany 11.10-11.30 “Sartorius BBI Systems Fermenters for microbial and cell culture cultivation” Popov A.Yu., AP International Ltd, Moscow 11.30-12.00 COFFEE BREAK 12.00-12.15 “UP-TO-DATE MEANS OF FILTRATION USED IN BIOTECHNOLOGICAL AND MICRO- Section 2.2. ANTIBACTERIAL THERAPY Co-Chairmen: Alexei M. Egorov, Professor, Academician of the RAMS, National Research Centre for Antibiotics (NRCA); Vitas K. Shvyadas, Professor, M. V. Lomonosov Moscow State University 10.00-10.20 “New Story for an Old Drug: Novel Antifungals Through Engineered Biosynthesis of Nystatin”. Sergey Zotchev, Department for Biotechnology; Norwegian University of Sciences & Technologies, Trondheim, Norway 10.20-10.40 “Potential for the Use of Supercritical Carbondioxide as Medium in Biotechnological Processes”. Estera S. Dey, Sweden 10.40-11.00 “Antimicrobial Peptides and Peptide Antibiotics”. T. V. Ovchinnikova; Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry, RAS, Moscow 11.00-11.20 “Gene Engineering Methods of Curing Latent Infections”. V. N. Lazarev, Research Institute for PhysicoChemical Medicine, Moscow, Russia 11.20-11.35 COFFEE BREAK 11.35-11.55 “New Forms of Antibacterial Preparations: 11.55-12.15 12.15-12.35 12.35-12.55 12.55-13.05 13.05-13.25 Pharmokinetics, Biological Availability, and Efficiency”. Yu. B. Belousov, Russian State Medical University, Moscow, Russia “Biocatalytic Technologies of Beta-Lactam Antibiotic Production”. A.M. Egorov, A.V. Sklyarenko, V.F. Kurochkina; National Research Centre for Antibiotics (NRCA), Moscow, Russia “Design of Biocatalysts and Antibiotic Synthesis Processes”. V.K. Shvyadas; M.V. Lomonosov Moscow State University, Moscow, Russia “Search for Antibacterial Antibiotics Effective Against Disease Agents Stable to the Known Medicinal Preparations”. G.S. Katrukha 1, L.P. Terekhova 1, O.V. Yefremenkova 1, N.M. Onatsky 2 , 1/ G. F. Gauze State Research Institute for Investigating New Antibiotics, RAMS, 2/ Research Center for Toxicology & Biopreparations, Russia “Collections of Microorganisms: New Possibilities of Search for Producers of Antibiotics”. M.V. Bibikova, A. M. Egorov; State Scientific Center of Antibiotics, Moscow, Russia “New Horizons of Application Lysoamidase in Medicine” I. S. Kulaev, O. A. Stepnaya, L.I. Marinin, N.A. Shishkova, G.K. Skryabin Institute of Biochemistry and Physiology of Microorganisms RAS, Pushchino, Russia Thursday, March, 16, 2006 SECTOR A CONFERENCE HALL (10.00-13.00) Section 1.3. GENE ENGINEERING TECHNOLOGIES Co-Chairmen: Sergey N. Kochetkov, Professor, Corresponding Member of the RAS, Head of the Laboratory of the Engelhardt Institute of Molecular Biology of the RAS; Olga O. Favorova, Professor, Head of the Department of Molecular Biology of the Russian State Medical University 10.00-10.25 “Significance of Gene Diagnostics in Pharmacotherapy Optimization”. V. G. Kukes, D. A. Sychev, I.V. Ignatiev; Institute of Clinical Pharmacology, Federal State Unitary Enterprise "Scientific Center of Expertise of Medical Application Means", Russia 10.25-10.50 “Medical Biotechnology and Gene Diagnostics”. L.P. Alekseyev, M.N. Boldyreva, D.Yu. Trophimov, Rebrikov D.V.1; Institute of Immunology, FMBA of Russia, 1 “DNA-technology, Ltd”, Russia 10.50-11.10 “DNA Diagnostics of Thrombophilia”. L. I. Patrushev; Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry, RAS, Russia 11.10-11.30 “Application of Short DNA in Biotechnology”. M. S. Klionov; Institute of Molecular Genetics, RAS, Russia 11.30-11.45 COFFEE BREAK 11.45-12.05 “The System Ensuring a High-Level Expression of Hepatitis C Virus Nonstructural Proteins”. Ivanov A.V.1,2, Tunitskaya V.L.1, Kukhanova M.K.1, Kochetkov S.N.1, 1 Engelhardt Institute of Molecular Biology, RAS, Moscow, Russia, 2Centre for Medical Studies, University of Oslo, Moscow, Russian Federation 12.05-12.25 “Obtaining of recombinant forms of the some immunodominant proteins from westernsiberian isolates of Lyme borreliosis causative agents and an evaluation of their diagnostic significance” Ryabchenko A.V., Karavaev V.S., Beklemishev A.B., State research institute of biological chemistry of Russian Academy of Medical Science, Novosibirsk 12.25-12.45 “Application of Retroviral Vectors in Biotechnology”. V. S. Praslov; Engelhardt Institute of Molecular Biology, RAS, Russia Thursday, March, 16, 2006 Thursday, March, 16, 2006 SECTOR Б CONFERENCE HALL SECTOR A CONFERENCE HALL Section 3.1. (10.00-13.00) BLOOD SUBSTITUTE AND PARENTAL NUTRITION Co-Chairmen: Andrey I. Vorobiev, Professor, Academician of the RAS, Academician of the RAMS, Director of the Hematological Scientific Center of the RAMS; Alexander V. Karyakin, Professor, Head of the Main Laboratory of the State Control of Blood Medication, Hematological Scientific Center of the RAMS 10.00-10.25 “Application of the Blood Substitutes and Means of Parental Nutrition in Medicine”. A.I. Vorobiev, Hematological Scientific Center, RAMS, Russia 10.25-10.45 “Nomenclature of Blood Substitutes and Parenteral Nutrition Preparations in Russian Federation”. A.V. Karyakin, RAMS Scientific Center of Hematology, Moscow, Russia 10.45-11.05 “A high-yield chromatographic production method for IVIG”. Lars-Olof Lindquist 1, Inger Andersson1 , 1 L&O Consulting, Uppsala, Sweden, 2 GE Healthcare, Uppsala, Sweden 11.05-11.25 “New Means of Parental Nutrition”. T. S. Popova, Parental Nutrition Society Association, Russia 11.25-11.40 COFFEE BREAK 11.40-12.00 “Monoclonal antibodies as therapeutic preparations”. A.V. Mazurov. Russian Cardiology Research and production Complex, Russian Ministry of Health, Russia 12.00-12.20 “Blood Substitutes With a Hemoglobin-Based Transport Function: Achievements and Perspectives”. Ye. A. Selivanov, Russian Research Institute for Hematology & Transfusiology, Russia 12.20-12.40 “The Producing of Hydroxyethyl Starch 200/0.5 Substation”. V. F. Traven; D. I. Mendeleyev Russian Chemical-Technological University, Russia 12.40-13.00 “Biodegradated blood substitutions” M. Shtilman1, A. Karyakin 2, А. Panov 1, S. Beksaev 2, 1Mendeleev University of chemical technology of Russia, 2National research centre for hematology of the RAMS, Moscow, Russia (14.00-16.00) Section 1.4. NEW MEDICAL FORMS Co-Chairmen: Evgeny S. Severin, Professor, Corresponding Member of the RAS, General Director of the All-Russia Research Center for Molecular Diagnostics & Therapy; Vitaly I. Shvets, Professor, Academician of the RAMS, Head of the Chair of Biotechnology, M.V. Lomonosov Moscow State Academy of Fine Chemical Technology 14.00-14.20 “Regulation of biosynthesis and maturation of neurotrophins as a mechanism of nervous system homeostasis maintenance” S.V.Kostrov, S.A.Limborska, N.F. Myasoedov, Institute of Molecular Genetics, RAS, Moscow, Russia 14.20-14.40 “Preparations to Cure Oncological Diseases on the Basis of Polymeric Nanoparticles: from Pre-Clinical Tests to Clinical Approbation of the Conception”. V. Yu. Alakhov; Supratek Pharma, Canada 14.40-15.00 “The problems of drug design with use of receptor mediated endocytosis”. E. S. Severin1, G. A. Posypanova2; 1 Russian Research Center for Molecular Diagnostics and Therapy; 2 Centre of "Bioengineering" RAS 15.00-15.20 “The Diversity of Lipid Nanostructures as Drug Delivery Systems”. A.P. Kaplun, U.U. Akhsyanov *, A.E. Stepanov, V.I. Shvets, M.V. Lomonosov State Academy of Fine Chemical Technology, Russia 15.20-15.40 “Nanotechnology: Enhancing Efficacy of a Antibacterial Agents” Svetlana Gelperina 1, 2, Sergey Vostrukhov 2, Peter Sveshnikov 1,2, 1Institute of Molecular Medicine, Sechenov Moscow Medical Academy, 2Research Center for Molecular Diagnostics and Therapy, Russia 15.40-16.00 “Vermiculture: new pharmaceuticals” I.N. Titov, S.S. Konin, The Corporation “GreenPIK”, Innovation Center, Vladimir, Russia Thursday, March, 16, 2006 SECTOR Б CONFERENCE HALL (14.00-16.00) Section 3.4. PHARMAECONOMICS Chairman: Pavel A. Vorobiov, Professor, Head of the Department of Standardization in Health Care of the I.M. Sechenov Moscow Medical Academy 14.00-14.30 «Pharmaeconomics in Russia”. P. A. Vorobiov, I. M. Sechenov Moscow Medical Academy 14.30-14.55 “ ‘Society of Pharmaeconomic Researches’ Interregional Public Organization. Its Activity, Work Experience of the Official Committee”. M.V. Surah 14.55-15.20 “Clinical and Economic Analysis in Assessment of Biotechnological Preparations’”. M.V. Avksentieva 15.20-15.45 “Standards of Highly Technological Means of Medical Help: The Place of Biotechnology”. L. V. Lukiantseva Thursday, March, 16, 2006 2 16.35-17.05 17.05-17.25 17.25-17.45 17.45-18.05 SMALL CONFERENCE HALL Section 3.3. (14.00-19.00) ANALYTICAL BIOTECHNOLOGY Co-Chairmen: Vadim M. Govorun, Professor, Deputy Director of the Institute of Physico-Chemical Medicine Boris B. Dzantiyev, Professor, Deputy Director of the A.N. Bakh Institute of Biochemistry of the RAS 14.00-14.20 “Modern Immunoassay Technologies and 14.20-14.40 14.40-15.00 15.00-15.20 15.20-15.40 15.40-16.00 Their Role in Diagnostics of Endocrine Disorders”. N.P. Goncharov, G. Katsya, A. Dobracheva, A.Nizhnik et al., National Center of Endocrinology, RAMS, Russia “Mass Spectrometric Assay Methods in Biotechnology”. Markus Kostratseva; Bruker Daltoniks, Germany “The Integrative Laboratory System Suitable for Monitoring of Bacterial Infections”. E.I. Ilyna; Research state Institute of PhysicoChemical Medicine, Russia “Usage of Biochips in Analytic Biotechnology”. A.S. Zasedatelev; Engelhardt Institute of Molecular Biology, RAS, Russia “New High-throughput Approaches in the Human Genome Studies” E.V. Generozov; Institute of Physico-Chemical Medicine, Moscow, Russia “Biotransducers and Biosensors for Detection of Biologically Active Compounds” B.B. Dzantiev, A.V. Zherdev, N.A. Byzova, A.N. Bakh Institute of Biochemistry, Moscow, Russia 16.00-16.15 COFFEE BREAK 16.15-16.35 “Diagnostic DNA-Chips in Clinical Microbiology for Rapid Pathogen and Antibiotic Resistance Identification”. Till T. Bachmann 1, Maya Yu. Rubtsova, Alexey M. Egorov 2, et al. , 1Institute of Technical Biochemistry, University of Stuttgart, Germany; 18.05-18.25 Dept.Chem.Enzymology, Chemistry Faculty, M.V. Lomonosov Moscow State University, Moscow, Russia “Applications of Thermometric Biosenors in Biomedical Ananlysis and Bioprocess Monitoring and Control”. Bengt Danielsson, Sweden “Methods of Analysis of the Gene Expression”. V.I. Sharov, OOO “TEKAN” “Chemical and Biological Sensors for Diagnostics of Oxidative Stress” E.E. Karyakina1, S.V. Morozov2, A.A. Karyakin1, 1Faculty of Chemistry of M.V. Lomonosov Moscow State University, 2 LTD “RuSens”, Moscow, Russia “Important Problems of Biotechnological Diagnostics in Russia” A.H. Asadi Mobarhan , Avicenna Medical Centr, Moscow, Russia “Universal Approach to Fabrication of DNA Chips. A New Strategy for Detection of SNP and Point Mutations in Analyzed DNA”. V.F. Zarytova 1, Pyshny D.V.1, Pyshnaya I.A.1, Ivanova E.M.1 et al., 1Institute of chemical biology and fundamental medicine SD RAS, 2 GSC virology and biotechnology “Vector” Novosibirsk, Koltsovo 18.25-18.40 “ECOLOGICAL SAFETY AND STIMULATING FEATURES OF INDIVIDUAL COMPOUNDS, INCLUDING MEDICINAL PREPARATIONS: NEW METHOD OF IDENTIFICATION”. P.Ye. Tulupov, S. P. Nikonova, Department of Ecology & Ecological Safety, International Academy of Modern Knowledge, Obninsk, Russia 18.40-18.55 “Method and Apparatus for Noninvasive Oxygen Saturation Monitoring in Biological Tissues and Microbiologic Specimen”. Vasilchenko S.Yu., Riabova A.V., Stratonnikov A.A., Loschenov V.B., NSC GFI RAS, Moscow, Laser Biospectroscopy Lab. Thursday, March, 16, 2006 SECTOR Т CONFERENCE HALL (11.00-14.30) Presentation Friday, March, 17, 2006 Universal exhibition Hall (10.00-12.30) COMPETITION OF YOUNG SCIENTISTS POSTER SESSION Chairmen: Vsevolod A. Tkachuk, Professor, Academician of the RAMS, Corresponding Member of the RAS, Dean of the Fundamental Medicine Faculty, M. V. Lomonosov Moscow State University Valery A. Bykov, Professor, Academician of the RAMS, Academician of the RAAS, Center of Biomedical Technologies, Institute of Herb and Aromatic Plants Vice-Chairmen: Tatiana V. Ovchinnikova, Professor, Head of the Teaching & Research Center of the Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry, RAS; Aleksei M. Egorov, Professor, Academician of the RAMS, M.V. Lomonosov Moscow State University CLOSING PLENARY SESSION SMALL CONFERENCE HALL (16.00 - 17.00) SUMMING UP RESULTS OF THE COMPETITION OF YOUNG SCIENTISTS, ADOPTING THE CONFERENCE RESOLUTION CO-CHAIRMEN: REM V. PETROV, PROFESSOR, ACADEMICIAN OF THE RAS, CHAIRMAN OF THE PROGRAM COMMITTEE OF THE CONGRESS VALERY A. BYKOV, PROFESSOR, ACADEMICIAN OF THE RAMS, ACADEMICIAN OF THE RAAS, CO-CHAIRMAN OF THE PROGRAM COMMITTEE OF THE CONGRESS PAVEL J. SARKISOV ACADEMICIAN OF THE RUSSIAN ACADEMY OF SCIENCES , CHAIRMAN OF THE Friday, March, 17, 2006 SMALL CONFERENCE HALL (13.00-16.00) Round-Table Seminar ANTI-INFLUENZA VACCINES Co-Chairmen: Anton V. Katlinsky, Professor, General Director of the NPO “Microgene”; Rem V. Petrov, Professor, Academician of the RAS, Head of the Department of Immunobiotechnology, Research Center of Immunology Institute; Topics for Discussion & Participants: “ Pro b le ms o f T hera py a nd Prev en t io n o f I nfl ue nza ” - O. I. Kiselev; Institute of Influenza, RAMS, Russia) “Vaccines Against Chicken Influenza Viruses”. - Ye. S. Voronin, K. I. Skryabin Moscow State Academy of Veterinary Medicine & Biotechnology, Russia; G.A. Safonov, Pokrovsky Factory of Biopreparations Federal State Unitary Enterprise, Russia “S u b u n i t a n d P o l y m e r i c Subunit Vaccines” - A. V. Nekrasov; NPO ‘Petrovaks FARM’ “V a c c i n e s B a s e d On Cellular Cultivated Viruses” I. Balabushkin I n d u s t r i a l Production of Vaccines Using Embryonic Cells in Gas-Vortex Gradientless Bioreactors - Yu.A. Ramazanov, JSC “Sajany”, Novosibirsk Friday, March, 17, 2006 SMALL CONFERENCE HALL (16.00-17.00) ORGANIZING COMMITTEE OF THE CONGRESS C O-CHAIRMEN OF THE M OSCOW I NTERNATIONAL C ONFERENCE BIOTECHNOLOGY AND MEDICINE Aleksei M. Egorov Academician of the Russian Academy of Medical Sciences, Anatoly I. Miroshnikov Academician of the Russian Academy of Sciences POSTER SESSION Wednesday , March, 15, 2006 10.00-18.00 Friday, March, 17, 2006 10.00-12.30 POSTER SESSION С.2.3.3. New cell culture media for blood lymphocytes Schepkina J.V., Kosyakova N.V., Martynov A.V., Chestkov V.V. , Research Centre for Medical Genetics RAMS, PanEco Ltd. С.2.3.4. The characterization of the new Bacillus subtilis strain, which proved to be prospective for the creation of probiotic preparation Gataullin A.G., Mikhailova N.A., Blinkova L.B., Gaiderov A.A., Gorobets O.B. I.I. Mechnikov Research Institute for Vaccines and Sera, RAMS С.2.3.5. ANTIOXIDANT ACTIVITY OF PROBIOTIC BIOPREPARATIONS L.V. Drachiova, International Academy of Informatization, Moscow, Russia Universal Exhibition Hall С.2.7.2. ON THE DIAGNOSTICS OF EARLY STAGES OF AMYLOIDOSIS AND ALZHEIMER’S DISEASE 1 2 3 С.1.2.5. Multivariate data mining techniques as advanced ADME filters Balakin K.V., Ivanenkov Y.A., Ivashchenko A.A., Chemical Diversity Research Institute, Russia, Moscow region, Khimki С.1.3.9. MDR1 gene рolymorphisms and optimization of pharmacotherapy of lymphoproliferative diseases Grishanova A.Y., Goreva O.B., Lyakhovich V.V. Institute of Molecular Biology & Biophysics, Siberian Branch of RAMS С.1.4.6. Polymer water-soluble metal complexes with biological activity Klyagina M.V.1,2, Tashmuhamedov R.I1, Goryachaya A.V.1, Shtilman M.I.1 et al., 1 D.I. Mendeleyev University of Chemical Technology, 2 N.F. Gamaleya Research Institute for Epidemiology and Microbiology, Gamaleya С.1.4.7. С.1.4.8. С.1.4.9. С.2.2.2. С.2.2.3. С.2.8.6. С.3.1.1. Polymeric macroporous hydrogels as drug carriers Artyukhov A.A.1, Zolotaykina T.S.1, Kuskov A.N.1, Shtilman M.I.1, Tsatsakis A.M.2, 1D.I. Mendeleyev University of Chemistry Technology of Russia, 2 University of Crete, Greece Polymer Coverings for Treatment of Radiation/Thermal Injuries Tavakalyan N.B.1, Hovhannisyan N.M.2, Bajinyan S.A.2, Poghosyan A.S.2 et al.,1 Yerevan “Plastpolymer” Institute, 2 Sector of Radiation Medicine and Burns, Center of Traumatology, Orthopedics, Burns and Radiology The antihemolytic, the antichlamydiotic and the antihelminthic activity of liposomes Ivanova N. N., Kharkov enerprise for manufacturing of immunobiological and medical preparations, JSC “Biolek” Aminoglucoside antibiotics prodoced by Streptoalloteychus cremeus subsp. Tobramycini Lapchinskaya O.A., Lavrova-Balashova M.F., Ponomarenko V.I., Katrukha G.S., G.F.Gause Research Institute of New Antibiotics of RAMS High-effective purification of antibiotic substances of glycopeptide and anthracycline nature on fluorine-inclusive sorbents Fedorova G.B., Katrukha G.S., Gause Institute of New Antibiotics, RAMS Fedyukin V., Maltsev A., Kaminsky Y., Bayramov V., 2 Brindar N.,1 Immunofarm Inc., SSC Applied Microbiology, Obolensk; 2 Institute of Cell Biophysics, RAS, Pushchino; 3 Institute of Biological Instrumentation, RAS, Pushchino; 4 Institute of Bioorganic Chemistry, RAS, Moscow Determination of Mechanism of Inhibition of Angiotensin-Converting Enzyme by Inhibitors РР-55-119 and РР-50 Napyorova I.A.1, Skirgello O.E.1, Binevski P.V.1, Pozdnev V.F.2, Kost O.A.1, 1Moscow State University, Chemistry Faculty, Moscow, 2Institute of Biomedical Chemistry, RAMS, Moscow The Outlook for Clinical Use of Antioxidant Modified Hydroxyethyl Starch Khrustalyva R.S.1, Domnina N.S.2, Tsyrlin V.A.1, Somov S.V.1 et al.,1 Almazov's Research Institute of Cardiology, 2 Saint-Petersburg State University, St. Petersburg, Russia Biotechnology of development of dairy products not containing lactose with added iodine and selenium on the basis of milk of goats S.F. Andrusenko, S.M. Kunizhev, E.V. Denisova, P.A.Omeljanchuk, Тhe Stavropol state university, Stavropol, Russia Biotechnological methods of deriving polysaccharides with antitumor activity from mycelium of Ganoderma lucidum medicinal basidial mushroom Krasnopolskaya1 L.M., Avtonomova1 A.V., Belitskii1 I.V., Isakova1 E.B. et al., 1 Gause Institute of New Antibiotics RAMS, ² Zelinsky Institute of 4 С.3.1.2. С.3.2.2. Organic Chemistry RAS, 3 Research institute of experimental diagnosis and therapy of tumors CRC RAMS, 4 Moscow factory of ecological technic and ecofood “DIOD” , Russia С.3.2.3. Criterion of Medicinal Basidial Mushrooms Submerged Culture Effectiveness – Biomass Production Over 20 g/ l Leontieva M.I., Avtonomova A.V., Belitskii I.V., Krasnopolskaya L.M., Gause Institute of New Antibiotics RAMS, Russia С.3.2.4. Strain characteristics of cultured culinarymedicinal basidiomycetes Lentinus edodes (Berk.) Sing. Soboleva N.Yu., Fedorova G.B., Katrukha G.S., Belitskii I.V., Krasnopolskaya L.M., Gause Institute of New Antibiotics RAMS, Russia С.3.3.9. Quantitative detection of biogenic amines and steroid hormones by method of massspectrometry in human urine and plasma Appolonova S.A., Dikunets M.A., Arhipenko N.V., Bykovskaya N.Uh., Rodchenkov G.M. Antidoping Centre, Moscow С.3.3.10. Detection of the nutrition related activity of the ATP-dependent proteolysis. Martinova E.A.1, Gapparov M.M.1, Rotanova T.V.2, 1State Institute of Nutrition RAMS, 2 M.M. Schemyakin & Yu.A. Ovchinnikov Institute of the Bioorganic Chemistry RAS, Moscow COMPETITION OF YOUNG SCIENTISTS С.1.2.4. Computer prediction of QT interval С.1.3.1. С.1.3.2. С.1.3.3. Friday, March, 17, 2006 10.00-12.30 С.1.1.1. Nanoscopy of DNA as a tool for biomedicine technologies Dubrovin E.V., Yaminsky I.V., Moscow State University, Leninskie Gory, Moscow, Russia С.1.1.2. Atomic balance, as the basis of biological and chemical sensor controls Kiselev G.A. 1, 2, 3, Yaminsky I.V. 1, 1 Moscow State University, Leninskie Gory, Moscow, Russia С.1.1.3. Polymeric nanoparticles - new delivery systems for poor-soluble drugs Kuskov A.N., Department of Polymers, D.I. Mendeleyev University of Chemical Technology, Russia С.1.1.4. Atomic force microscopy of bacterial cells Lomonosov A.M.1,2, Yaminsky I.V.1,2, 1 A.N.Nesmeyanov Institute of Organoelement Compounds RAS, 2Biosensor Academy С.1.3.4. С.1.3.5. С.1.3.6. С.1.3.7. С.1.1.5. Nanocontainers for absorption and targeted delivery of bioactive compounds Tourleigh Ye.V., K.V. Shaitan, Moscow State University, Dept. of Bioengineering, Russia С.1.2.1. Developing the informational resource on structural-functional variability of proteins of Hepatitis C virus K.Ye. Aleksandrov, Institute of Biomedical Chemistry of the RAMS, Russia C.1.2.2. New method of quantitative structure-activity relationships: validation on the basis of cyclindependent kinase inhibitors Zakharov A.V., Lagunin A.A., Filimonov D.A., Poroikov V.V., Institute of Biomedical Chemistry, RAMS, Russia С.1.2.3. Molecular dynamics of nootropic agent SEMAX and its analogous. Tereshkina K.B., Shaitan K.V. Moscow State University, Faculty of Biology, Dept. of Bioengineering С.1.3.8. С.1.4.1. С.1.4.2. С.1.4.3. prolongation for different classes of pharmaceuticals agents Filz O.A., Poroikov V.V, Institute of Biomedical Chemistry of RAMS Application of protein splicing system for singlestep purification of human epidermal growth factor Beyrakhova K.A., Kostromina M.A., Stepanenko V.N., Esipov R.S.*, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, RAS Approaches to design of new cationic amphiphiles for the purposes of applied medicine Sebyakin Yu.L., Budanova U.A., Muhina A.K., Charitonova O.A., M.V. Lomonosov State Academy of Fine Chemical Technologyа Using of the retroviral vectors to develop the technology for production of genetically modified chicken Volkova N.A., Volkova L.A., Zinovieva N.A., Ernst L.K., All-Russian State Research Institute of Animal Breeding of the RAAS Recombinant oxyntomodulin — a potential medicine for obesity Kostromina M.A., Beyrakhova K.A., Stepanenko V.N., Esipov R.S.*, ShemyakinOvchinnikov Institute of Bioorganic Chemistry, RAS Genetic transformation spermatogonia cells in vivo as an alternative way to produce transgenic farm animals Novgorodova I.P., Zinovieva N.A., All-Russian State Research Institute of Animal Breeding of the RAAS Complex multivariative analysis of genetic factors of ischemic stroke and its clinical traits Parfenov M.G., Cardiology Research Center Cell hybridization as a possibility to decrease the histocompatibility barrier Grezina N.M., Klenovitsky P.M., Zinovieva N.A., Ernst L.K., All-Russian State Research Institute of Animal Breeding of the RAAS Genetic and transcriptional mechanisms of placental insufficiency. Nikitina L.A., Moscow State University, Faculty of Medicine Pro and Prebiotics: clinical application Azizpour, Khalil, Artemia and Aquatic animals Research Institute, Urmia University, Urmia-Iran Alginate matrices ultrasonic modification for the develop the drug delivery systems with set properties on their basis Manaenkov O.V.1, SidorovA.I.1, Smirnova L.E.2, Sulman E.M.1, Vinogradov V.F.2. 1 Tver state technical university, 2Tver state medical academy, Russia Comparison of dialysis methods of protein drugs inclusion into erythrocytes Tikhonova A.G.1, Vuimo T.A. 1, Aleksandrovich Yu.G.2, Sinauridze E.I.1 et al., 1 National Research Center for Hematology, RAMS, 2 M.V. Lomonosov Moscow State Academy of Fine Chemical Technology С.1.4.4. New negatively charged inhibitors of the С.1.4.5. С.2.1.1. С.2.1.2. С.2.1.3. С.2.1.4. С.2.2.1. С.2.3.1. С.2.3.2. С.2.5.1. complement system Rukosueva N.V.,1 Bureeva S.V.,1 Moskaleva V.V.,1 Karlinsky D.M.,2 Popov M.E.,2 Andia-Pravdivy J.E.1, 1M.V. Lomonosov Moscow State Academy of Fine Chemical Technology , 2M.M. Shemiakin and Y.A Ovchinnicov Institute of Bioorganic Chemistry RAS Biotechnology of reception of antidotes Fill A.A., Vorobjeva O.V., Avanesyan S.S., Karchinskaya T.A., The Stavropol state university, Stavropol Erythrocyte as a 'depot' and carrier of mitoxantrone. Aleksandrovich Yu.G.1, Vuimo T.A.2, Sinauridze E.I.2, Lisovskaya I.L.2, Ataullakhanov, F.I.2, 1 M.V. Lomonosov Moscow State Academy of Fine Chemical Technology, 2 National Research Center for Hematology, RAMS Directed proteolysis activity and apoptosis induction in the normal and tumor cells Puzanova O.P.1, Martinova E.A.2, 1Volgograd’ State Medical University, 2State Institute of Nutrition RAMS Analysis of gene expression in human breast cancer samples and in adjacent normal tissue using cDNA arrays Smolyanova G.G.; Beabealashvilli R.Sh., Russian Cardiology Researh and Production Center Immunoliposomes as the carriers of anticancer drugs. Barishnikov A. Yu., Oborotova N. A., Tolcheva E. V., N.N. Blokhin Russian Cancer Research Center RAMS Molecular dynamics simulation of membrane channels by the example of Gramicidin A Levtsova O.V., Shaitan K.V., Lomonosov Moscow State University, Dept. of Bioengineering Immunological properties of combined antiHIV-vaccine Uzhachenko R.V., Karpenko L.I., The State Science Centre of Virusology and Biotechnology “Vector”, Institute of Bioengineering, Novosibirsk Design and immunogenic properties of chimeric core particles hepatitis B carrying epitopes of hepatitis B surface protein preS region Veremeyko T.A., Zaitsev B.N., Karpenko L.I. Laboratory of immunoprofilactic, SRC VB "Vector", Koltsovo, Novosibirsk region Inhibition of low density lipoproteins association by means of Pluronic Aksenov D.V., Orekhov A.N., Institute of the General Pathology and Pathophysiopathology of RAMS С.2.5.2. Pharmacokinetic of prourokinase recombinant Belyanko T., Beabealashvilli R., Russian Cardiology Research and Development Center С.2.5.3. Investigation of immunochemical properties of N-terminal pro-brain natriuretic peptide precursor circulating in patient’s blood Seferian K.R., Semenov A.G., Moscow State University, School Biology, Biochemistry Department С.2.5.4. TnI as the marker for differentiating stem cell- derived cardiomyocytes Solovieva1 T.I. Kharitonov3, Moscow State University. С.2.5.5. The BNP immunoreactivity in plasma of heart failure patients is represented mostly by proBNP form Tamm N.N., Tolstaya A.A., Moscow State University, School Biology, Biochemistry Department С.2.5.6. Gene expression analysis in peripheral blood leukocytes from patients with arterial hypertension Timofeeva A.V., Beabealashvilli R.Sh., Russian Cardiology Reseach and Development Complex С.2.5.7 . Effect of Catalase-ChondroitinsulfateSuperoxide Dismutase Conjugate on ADP- and H2O2-induced Platelet Activity Vavaev A.V. & Maksimenko A.V., Institute of Experimental Cardiology, Russian Cardiology Research-and-Production Complex С.2.5.8. Natural preparations of series "Astin" – "Bioastin" reliable antioxidant cardiological protection an organismа Ekpeniong L.A., Kubik V.M., Yakushin S.S., . ”Istochnik Dolgoletia” Moscow С.2.7.1. GAPDH as a promising target for a drug screening against neurodegenerative diseases Naletova I.N1, Schmalhausen E.V1, Saso L.3, Pleten' A.P.1, Muronetz V.I1,2, 1 Belozersky Institute of Physico-Chemical Biology and 2 School of Bioengineering and Bioinformatics С.2.8.1. Effect of heparins on the activation kinetics of Glu-plasminogen and Lys-plasminogen by staphylokinase Gulin D.A.2, Mukhametova L.I.1, Gershkovich K.B.2, Aisina R.B.1, Varfolomeyev S.D.2 1 Chemistry Faculty, Lomonosov Moscow State University, 2 Institute for Biochemical Physics, Russian С.2.8.2. Inhibition mechanism by ω-amine acids of fibrinolysis initiated by staphylokinase Levashov M.Y., Aisina R.B., Varfolomeyev S.D., Chemistry Faculty, Lomonosov Moscow State University С.2.8.3. Correlation between Glu-plasminogen conformation and kinetic parameters of its activation by staphylokinase Mukhametova L.I., Aisina R.B., Varfolomeyev S.D., Chemistry Faculty, Lomonosov Moscow State University С.2.8.4. Thrombin receptor agonist peptide as a novel antiulcerogenic factor Rusanova A.V. Makarova A.M., Marcvicheva E.A.1, Grandfils Ch.2, Strukova S.M, The Lomonosov Moscow State University, Department of Human & Animal Physiology, 1 Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, RAS, 2 Interfacultary Biomaterial Centre (CEIB), University of Liege, Belgium С.2.8.5. New approach to increase sperm motility Shchutskaja Y.Y.1, Yurjeva M.V.2, Bragina E.E.3, Schmalhausen E.V3. , 1 School of Biology, 2 School of Bioengineering and Bioinformatics, Lomonosov Moscow State University , 3Belozersky Institute of Physico-Chemical Biology С.3.2.1. The Stevioside’s Production Wastes As Raw С.3.3.1. С.3.3.2. С.3.3.3. С.3.3.4. С.3.3.5. С.3.3.6. С.3.3.7. С.3.3.8. Material For Biologically-active Addition’s Getting Tsugkieva E.B., Russian Chemic-technological University by D.I. Mendeleev Method for identification from genetically modified organisms of plant origin using enzyme analysis on a biological array Kashina N.A., Institute of Nutrition, RAMS Planar biosensors for clinical analysis of glucose Revunova K.V.1, Lukachova L.V.1, Karyakina E.E.1, Karyakin A.A.2, 1 Chemical Enzymology Department, 2 Laboratory of Electrochemical Methods, Faculty of Chemistry of M.V. Lomonosov Moscow State University Stoichiometry of electrocatalytic cycle of cytochrome P450 2B4 Rudakov Yuri O., Shumyantseva Victoria V., Institute of Biomedical Chemistry, RAMS Enzyme-linked immunosorbent assay for bisphenol A in river water Krapivin A.S., Samsonova J.V., Uskova N.A., Ivanova N.L., Egorov A.M., Chemistry Faculty, M.V. Lomonosov MSU Enzyme immunoassay techniques based on highaffine interaction between barnase and its inhibitor barstar Urusov A.E.1, Balandin T.G.2, 1Bakh Institute of Biochemistry RAS, 2Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry RAS Development of immunofluorescence and immunoenzyme methods for class-specific determination of sulfonamides Tafintseva I.Yu.1, Nesterenko I.S.2, 1A.N. Bakh Institute of Biochemistry of Russian Academy of Science, 2M.V. Lomonosov Moscow State University Novel End-point PCR based assay for detection of 11 high-risk HPV genotypes Nasonova V., Kuevda D. Central Research Institute of Epidemiology Enzyme immunoassay of sulfamethoxypyridazine using biotin/streptavidin pair Berlina, A.N.1, Alpeeva, I.S.2, Zherdev, A.V.3, Dzantiev, B.B.3, Sakharov, I.Yu.1,2 1 G. V. Plekhanov Russian Economic Academy, Moscow, Russia, 2Department of Chemistry, the M. V. Lomonosov State University, Moscow, Russia, 3 A. N. Bakh Institute of Biochemistry, RAS, Moscow, Russia