G
ENERAL
Professor of Biology and Health Sciences and Technology
Department of Biology
Room 68-370A
Massachusetts Institute of Technology
Cambridge, Massachusetts 02139
Phone: (617) 253-6721
Fax: (617) 253-8550 e-mail: asinskey@mit.edu
Date of Birth: April 1, 1940
Place of Birth: Highland, Illinois
Marital Status: Married
Residence: 285 Commonwealth Avenue
Boston, Massachusetts 02115
E
DUCATION
Institution
University of Illinois
Urbana, Illinois
Massachusetts Institute of Technology
Cambridge, Massachusetts
Degree
B.S.
Sc.D.
Period
1958-1962
1962-1966
Harvard School of Public Health Post Doctoral Fellowship 1967-1968
Boston, Massachusetts
M AJOR R ESEARCH I NTERESTS
 Microbiology
 Biotechnology
 Metabolic and Biopolymer Engineering
 Mammalian Cell Culture
1

E XPERIENCE
 2009 - Present
 2004 - Present
 1998 - Present
 1988 - 1998
Professor of Engineering Systems
Engineering Systems Division
Massachusetts Institute of Technology
Professor of Health Sciences and Technology
Dept. of the Harvard-MIT Division of Health Sciences and
Technology
Massachusetts Institute of Technology
Professor of Microbiology
Dept. of Biology
Massachusetts Institute of Technology
Professor of Microbiology
Dept. of Biology and Associate Director
 1977 - 1988
 1971 - 1977
 1968 - 1971
Biotechnology Process Engineering Ctr.
Massachusetts Institute of Technology
Professor of Applied Microbiology
Dept. of Applied Biological Sciences
Massachusetts Institute of Technology
Assoc. Professor of Applied Microbiology
Dept. of Nutrition and Food Science
Massachusetts Institute of Technology
Asst. Professor of Applied Microbiology
Dept. of Nutrition and Food Science
Massachusetts Institute of Technology
D EPARTMENTAL C OMMITTEES A ND A CTIVITIES
 Director, MIT Summer Professional Program 20.50s - Methods, Logic and
Opportunities in Metabolic Engineering, 1997-2000
2

 Co-Director and Session Moderator, Professional Symposium - The Future of the
Pharmaceutical Industry, 1999.
 Undergraduate Writing Requirement Coordinator, 1989 - 1997
 Graduate Student Admission Committee, 1983 - 1988
 Summer Course, Biotechnology: Principles and Processes, 1983 - 1997
 Summer Course, Biotechnology: Fuels, Chemicals and Ingredients by Fermentation
Processes, 1982
 ABS Financial Aid Committee, 1981 - 1982
 ABS Undergraduate Affairs Committee, 1981 - 1982
 ABS Graduate Admissions Officer, 1979 - 1982
 ABS Graduate Registration Officer, 1976 - 1982
 ABS Undergraduate Registration Officer, 1971 - 1982
 ABS Curriculum Committee, 1969 - 1982
 Summer Course, Biotechnology: Chemicals and Fuels from Anaerobes, 1981
 Summer Course, Advances in Food and Applied Microbiology, 1978 - 1980
M.I.T.
C
OMMITTEES AND
A
CTIVITIES
 Member, Faculty Policy Committee, 2007 - 2010
 Member, Committee on Toxic Chemicals, 2006 - 2009
 Faculty director, MIT Center for Biomedical Innovation, 2005 - present
 Co-director, MIT Program on the Pharmaceutical Industry, 1991 - 2005
 Member, Biomedical Enterprise Program (BEP) Steering Committee, 2002 - present
 Member, Undergraduate Education Committee, 1999
 Member, Faculty-Administration Committee, 1999
 Member, CJA Committee, 1995 -1997.
 Member, Committee on Toxic Chemicals, 1990 - 1993
 Chairman, BPEC Annual Symposium, 1987 - 1992
 Member, Faculty Policy Committee, 1986 - 1989
3

 Operating Committee for Biotechnology Engineering Process Center, 1985 - 1998
 Freshman Advisor, 1979 - Present
 Interdepartmental Committee for Biotechnology, 1983 - 1987
 Advisor, Board of Counselors, Harvard-M.I.T. Division of Health Sciences and
Technology M.D.-Ph.D. Program, 1978 - 1986
 Associate Director for Sea Grant Research Coordination, 1980 - 1984
 Member, Faculty Sea Grant Council, 1978 - 1982
 Member, Committee on Graduate Student Policy, 1976 - 1982
 Member, Committee on Educational Policy, 1976 - 1982
 Member, Institute Council on Environmental Health and Safety, 1977 - 1979
 Chairman, Radiation Protection Committee, 1975 - 1979
 Member, Premedical Advisory Council, 1977
M EMBERSHIPS
 National Association of Corporate Directors, Member, 2006
 American Association for the Advancement of Science, Fellow, 1997
 American Society for Microbiology
 American Institute for Medical and Biological Engineering, Fellow, 1996
 Molecular Medicine Society, Fellow, 1996
 American Chemical Society, Microbial Chemistry and Technology Division Sigma Xi
 Institute of Chemistry and Cell Biology (Harvard Medical School), Associate Member,
2001
A WARDS AND H ONORS
 Fellow of The Cambridge-MIT Institute (CMI) Project, 2002-2003
 Chair of International Symposium on Biological Polymers, 2000
 Chair of Metabolic Engineering III Conference, 2000
 Fellow of the American Association for the Advancement of Science, 1996
 Fellow of the Molecular Medicine Society, 1996
4

 Fellow of the American Institute for Medical and Biological Engineering, 1996
 NSERC (Canada) Strategic Grant Selection Panel on Biotechnology, 1995-1998
 Japanese Lectureship, Enzyme Engineering, 1989
 Distinguished Lectureship, Taiwan National Research Council, 1989
 Distinguished Lectureship, Snow Brand Life Sciences Institute, 1987
 Canadian Society of Microbiologists, Hotpack Lecturer, 1981
 1975 Samuel Cate Prescott, IFT's Outstanding Young Research Award
 IFT Gerber Scholarship Award, 1960 - 1962
A DVISORY G ROUPS
 Cell Culture Engineering Steering Committee, 2002.
 Food Safety Expert, Animal Health Institute, 1992.
 Councilor, Biodegradable Polymer Society of America, 1991.
 Board of Advisors, Center for Biotechnology Engineering, Northeastern University, 1990
– Present.
 National Research Council's Associateship Program Review Panel, 1988 – Present.
 NSF/France Joint Biotechnology Panel, 1987 – 1992.
 Office of Naval Research, Materials Research Committee, 1986 - Present
 NSF Biotechnology, Review Panel, 1986 – Present.
 IFT Publication Information Program, 1985 – Present.
 UNIDO Panels on Biotechnology, 1983 – 1987.
 Member of Center of Biotechnology Advisory Committee – Stanford University and
University of California, Berkeley, 1983 – 1986.
 Steering Committee of Proposed Biotechnology Division IFT, 1983 – 1986.
 American Academy for Microbiology, Committee on Ethics, 1979 – 1982.
 American Society for Microbiology, Committee on Agriculture, Food and Industrial
Microbiology, 1979 – 1981.
 International Atomic Energy Agency, Working group on "Radio sensitivity of
Pathogenic Microorganisms in Sewage and Wastes", 1977 – 1980.
5

 National Research Council, Committee on Microbiology of Food, 1976 – 1979.
 Scientific Advisor, FDA, Boston District, 1973 – 1978.
 NASA, Manned Space Research Center, Alabama, 1972 – 1975.
E DITOR (R EVIEWER )
 Editorial Advisory Board, Journal of Tropical Forest Science, 2006 – Present.
 Editor, Process Biochemistry, 2006 – 2009.
 Editorial Advisory Board, PharmaGenomics, 2002 – 2006.
 Editorial Board, Applied Microbiology and Biotechnology, 2001 – Present.
 Advisory Board, Biomacromolecules, 1999 – 2004.
 Associate Editor, Bioprocess and Biosystems Engineering, 2001 – Present.
 Editor, Metabolic Engineering Journal, 1999 - Present.
 Associate Editor, Biocatalysis, 1989 - 1999.
 Editorial Board, Journal of Applied Biochemistry and Biotechnology, 1986 - Present.
 Advances in Marine Science and Biotechnology, John Wiley and Sons, 1983.
 Reviews for Applied and Environmental Microbiology, Journal of Food Science,
Biochemistry, Journal of Agriculture and Food Chemistry, Journal of Bacteriology,
Science, In Vitro, Biotechnology & Bioengineering.
 Associate Editor of International Journal of Radiation Sterilization, 1972 – 1980.
 Editorial Board of Applied and Environmental Microbiology, 1974 – 1980.
 Journal of the International Solar Energy Society, reviewer, 1981 – 1982.
 Trends in Biotechnology, 1983 –1996.
B
OOKS
 Colwell, R.R., E.R. Pariser and A.J. Sinskey (Eds.). 1985. Biotechnology of Marine
Polysaccharides. Hemisphere Publishing, New York.
 Colwell, R.R., E.R. Pariser and A.J. Sinskey (Eds.). 1984. Biotechnology in the Marine
Sciences. Proceedings of the First Annual MIT Sea Grant Lecture and Seminar. McGraw
Hill, New York.
6

 Nickerson, J.T.R. and A.J. Sinskey. 1972. Microbiology of Foods and Food Processing.
American Elsevier Publishing Co., New York.
T
ECHNICAL
R
EPORTS
 Council on Materials, Division of Materials Sciences, U.S. Department of Energy, Panel
Report “Enzymatic Synthesis of Materials,” March 1988.
 Office of Technology Assessment, “Impacts of Applied Genetics: Microorganisms,
Plants, and Animals,” Major contributor, 1980.
 Committee on Microbiology of Food, Advisory Board on Military Personnel Supplies,
Report No. 89, National Research Council, 1978.
 Committee on Microbiology of Food, Advisory Board on Military Personnel Supplies
Report No. 77, National Research Council, 1977.
 Scrimshaw, N.S., J.E. Austin, J.R. Harris, C. Rha and A.J. Sinskey. 1973. M.I.T.
International Nutrition Planning Program, Technical Report, Series No. 1, "High Protein
Development Efforts in Thailand, M.I.T. Press, Cambridge, MA.
P ATENTS
 Feedback-resistant pyruvate carboxylase gene from corynebacterium. Hanke, P.D.
Sinskey, A.J., Willis, L.B., Guillouet, S., 2007. U.S. Patent 7,300,777.
 Methods for producing L-isoleucine. Guillouet, S., Sinskey, A.J., Rodal, A.A., Lessard,
P.A., 2006. U.S. Patent 9,987,017.
 Feedback-resistant pyruvate carboxylase gene from corynebacterium. Hanke, P.D.
Sinskey, A.J., Willis, L.B., 2005. U.S. Patent 6,965,021.
 Pyruvate carboxylase from Corynebacterium glutamicum. Sinskey, A.J., Lessard, P.A.,
Willis, L.B., 2005. U.S. Patent 6,884,606.
 Method and deregulated enzyme for threonine production. Archer, J.A.C., Follettie,
M.T., Sinskey, A.J., 2003. U.S. Patent 6,649,379.
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 Methods for Producing L-Isoleucine. Guillouet, S., Rodal, A.A., Lessard, P.A., Sinskey,
A.J., 2002. U.S. Patent 6,451,564 B1.
 Pyruvate Carboxylase from Corynebacterium glutamicum. Sinskey, A.J., Lessard, P.A.,
Willis, L.B., 2000. U.S. Patent 6,171,833.
 Method for Controlling Molecular Weight of Polyhydroxyalkanoates. Snell, K.D.,
Hogan, S.A., Sim, S.J., Sinskey, A.J., Rha, C.K., 1997. U.S. Patent 5,811,272.
 Gene Encoding Bacterial Acetoactyl-CoA Reductase. Peoples, O.P., Sinskey, A.J., 1998.
U.S Patent 5,798,235.
 Method for Producing Polyester Biopolymers. Peoples, O.P., and Sinskey, A.J., 1997.
U.S. Patent 5,663,063.
 Gene Encoding Bacterial Beta-Ketothiolase. Peoples, O.P., and Sinskey, A.J., 1997. U.S.
Patent 5,661,026.
 Glutamicum Threonine Biosynthetic Pathway. Sinskey, A.J., Follettie, M.T., Liebl, W and Peoples, O.P., 1997. U.S. Patent 5,641,660.
 Polyhydroxybutyrate polymerase. Peoples, O.P., and Sinskey, A.J., 1996. U.S. Patent
5,534,432.
 Gene Encoding Bacterial Acetoacetyl-CoA Reductase. Peoples, O.P., and Sinskey, A.J.,
1996. U.S. Patent 5,512,669.
 Process for Preparing Glucanase Resistant Yeast Mutants. James, S., Rha, C.K. and
Sinskey, A.J., 1996. U.S. Patent 5,506,124.
 Overproduction and Purification of Soluble PHA Synthase. Peoples, O.P., Gerngross,
T.U., Sinskey, A.J., 1995. U. S. Patent 5,480,794.
 Glucan Composition and Process for Preparation Thereof. Jamas, S., Rha, C.K. and
Sinskey, A.J., 1993. U.S. Patent 5,250,436.
 Polyhydroxyalkanoate Polymerase. Peoples, O.P., Sinskey, A.J., 1993. U.S Patent
5,250,430.
 Method for Producing Novel Polyester Biopolymers. Peoples, O.P., Sinskey, A.J., 1993.
U.S. Patent 5,245,023.
 Method for Producing Novel Polyester Biopolymers. Peoples, O.P., Sinskey, A.J., 1993.
U.S. Patent 5,229,279.
8

 Enzymatic Coal Desulfurization. Kern, E.E., Menger, W.M., Odelson, D.A., Sinskey,
A.J., Wise, D.L. and Trantolo, D.J., 1992. U.S. Patent 5,094,668.
 Non-capsule exopolysaccharide from Zoogloea ramigera. Easson, D.D., Peoples, O.P. and
Sinskey, A.J., 1992. U.S. Patent 5,091,376.
 Glucan Composition and Process for Preparation Thereof. Jamas, S., Rha, C.K. and
Sinskey, A.J., 1992. U.S. Patent 5,082,936.
 Glucan Composition and Process for Preparation Thereof. James, S., Rha, C.K. and
Sinskey, A.J., 1991. U.S. Patent 5,037,972.
 Glucan Composition and Process for Preparation Thereof. James, S., Rha, C.K. and
Sinskey, A.J., 1991. U.S. Patent 5,028,703.
 Method for Utilizing and Exocellular Polysaccharide Isolated from Zoogloea ramigera.
Rha, C.K., Pradipasena, P., Nakamura, T., Easson, D.D., Jr. and Sinskey, A.J., 1991. U.S.
Patent 5,008,108.
 Glucan Composition and Process for Preparation Thereof. Jamas, S., Rha, C.K. and
Sinskey, A.J., 1991. U.S. Patent 4,992,540.
 Coryneform Expression and Secretion System. Sinskey, A.J. and Liebl, W., 1990. U.S.
Patent 4,965,197.
 Zoogloea Transformation Using Exopolysaccharide Non-capsule Producing Strains.
Easson, D.D., Peoples, O.P., Sinskey, A.J., 1990. U.S. Patent 4,948,733.
 Method for Utilizing an Exocellular Polysaccharide Isolated from Zoogloea ramigera. Rha,
C.K., Pradipasena, P., Nakamura, T., Easson, D.D., Jr. and Sinskey, A.J., 1989. U.S. Patent
4,851,393.
 Glucan Composition and Process for Preparation Thereof. Jamas, S., Rha, C.K. and
Sinskey, A.J., 1989. U.S. Patent 4,810,646.
 Cloning Systems for Corynebacterium. Sinskey, A.J., Walker, G.C., Higashio, R., Rao,
E.A., Shanabruch, W.G., and Yoshihama, M., Follettie, M., 1987. U.S. Patent 4,649,119.
 Process for Reducing Nucleic Acid Content of Yeasts and Bacteria. Tannenbaum, S.R.,
Sinskey, A.J. and Maul, S.B., 1976. U.S. Patent 3,968,009.
 Aliphatic Diols and their Esters as Antimicrobial Additives for Cheese and Meats.
Frankenfeld, J.W., Karel, M., Labuza, T.P. and Sinskey, A.J., 1974. U.S. Patent 3,806,615.
9

 Process of Reducing the Nucleic Acid Content in Yeast. Tannenbaum, S.R., Sinskey, A.J. and Maul, S.R., 1973. U.S. Patent 3,720,585.
P ROFESSIONAL A CTIVITIES O UTSIDE OF M.I.T.
 3 rd Singapore Lipid Symposium, Singapore; March 3-5, 2010; Invited Speaker.
 BioMalaysia 2009; Kuala Lumpur, Malaysia; November 17-19, 2009; Invited Speaker.
 2 nd International Conference on Bio-based Polymers 2009 (ICBP); Penang, Malaysia;
November 11-13, 2009; Invited Speaker.
 Università degli Studi di Milano; Milan, Italy; June 22-23, 2009; Invited Lecturer.
 International Symposium on Biological Polyesters (ISBP 2008); Auckland, New Zealand;
November 22-26, 2008; Keynote Speaker.
 Crossroads of Biotechnology Conference; Montreal, Canada: March 21-22, 2006, Invited
Speaker.
 International Program Committee (IPC) for the IASTED International Conference on
Advanced Technology in the Environmental Field (ATEF 2006); Lanzarote, Spain;
February 6-8, 2006, Member.
 Bioselangor 2005; Selangor, Malaysia; August 29-30, 2005; Invited Speaker.
 Biotechnology Asia 2005; Kuala Lumpur, Malaysia; August 16-17, 2005; Invited Speaker.
 National Conference on Biotechnology of Plantation Commodities; Selangor, Malaysia;
August 9-11, 2005; Invited Speaker.
 Cooperative Research Centre for Sugarcane Innovation through Biotechnology (CRC
SIIB) symposium; Brisbane, Australia; November 16-17, 2004; Invited Speaker.
 International Symposium on Biological Polyesters (ISBP 2004); Beijing, China; August
22-28, 2004; Invited Speaker.
 Recent Advances in Fermentation Technology Conference (RAFT V), St. Petersburg, FL;
November 2003; Invited Keynote Speaker.
 BIO2003, Biotechnology Industry Organization Conference; Washington, D.C.; June
2003; Invited Speaker.
 Sino-American Pharmaceutical Professionals Association New England 6 th Annual
Scientific Conference, Cambridge, MA; June 21, 2003; Invited Speaker.
10

 M.I.T. - Industrial Liaison Program; 5 th Annual Conference in Japan; January 15-21, 2003;
Presenter of Lectures and Seminars.
 Metabolic Engineering IV Conference; Il Ciocco, Italy; October 6-11, 2002; Invited
Speaker.
 BioMalaysia 2002; Kuala Lumpur, Malaysia; October 1-4, 2002; Invited Speaker.
 International Symposium on Biological Polyesters (ISBP 2002); Münster, Germany;
September 22-26, 2002; Invited Speaker.
 BIO2002, Biotechnology Industry Organization Conference; Toronto, Canada; June 2002;
Invited Speaker.
 11 th Annual Merck Sponsored Distinguished Lectures in Chemical & Biochemical
Engineering; Rutgers University, New Jersey; February, 2001; Collaboratus XI Lecturer,
"Biopolymer Engineering: from Genes to Enzymes to Heart Valves."
 12 th National Biotechnology Seminar; Kuala Lumpur, Malaysia; November, 2000;
Invited Speaker, "Drug Discovery: the Search for Tractable Targets."
 Metabolic Engineering III Conference; Colorado Springs, Colorado; October 2000;
Chairman and Member of the Steering Committee.
 International Symposium on Biological Polyesters (ISBP 2000); Boston, Massachusetts;
September 2000, Chairman.
 BIO2000, Biotechnology Industry Organization Conference; Boston, Massachusetts;
March 2000; Invited Speaker.
 4 th International Congress on Biochemical Engineering/Financing Biotechnology II;
Stuttgart, Germany; February 17-18, 2000; Keynote Speaker.
 11 th National Biotechnology Seminar; Kuala Lumpur, Malaysia; November 1999; Invited
Speaker.
 PORIM International Palm Oil Conference; Kuala Lumpur, Malaysia; 1-6 February 1999;
Keynote Speaker.
 Metabolic Engineering II Conference; Schloss Elmau, Elmau/Oberbayern (Bavaria),
Germany; 25-30 October 1998; Co-Chair and Member of Steering Committee.
 The Bioscience Revolution, Bioscience York Meeting; November, 13th 1996; Invited
Speaker.
11

 Natural Sciences and Engineering Research Council of Canada (NSERC); Strategic Grant
Selection Panel on Biotechnology; 1995-1998.
 BPEC Symposium & Workshop, “Therapeutic Protein Production and Processing &
Bioprocessing Needs for Cell Based Therapies”; M.I.T.; January 18-19, 1995.
 Center for Talented Youth (CTY), Johns Hopkins University; October 29, 1994; Lecturer.
 Cell & Tissue Reactor Engineering, University of Minnesota; August 22-24, 1994;
Lecturer.
 International Symposium Bacterial Polyhydroxyalkanoates (ISBP’94); McGill University;
August 14-18, 1994; Lecturer.
 Advances in Biopolymer Engineering Conference; Palm Coast, Florida; January 23-28,
1994; Co-chair.
 The John Ugelstad Conference, M.I.T.; April 18-20, 1993; Chairperson.
 Fifth ASM Conference on Genetics and Molecular Biology of Industrial Microorganisms;
October 11-15, 1992; Invited Speaker, "Recent Advances in the Genetics and Molecular
Biology of Corynebacterium".
 Animal Cell Reactor Engineering, Short Course; University of Minnesota; August 31 -
Sept. 3, 1992; Lecturer.
 International Symposium on Bacterial Polyhydroxyalkanoates, ISBP ’92; Gottingen,
Germany; June 1-5, 1992; Invited Speaker, “Recent Advances in the Biosynthesis of
Polyhydroxyalkanoates.”
 Symposium on the Biosynthesis of Non-Template Derived Polymers, American
Chemical Society Meeting; San Francisco, California; April 5-10, 1992; Invited Speaker,
“Recent Studies on the Biosynthesis and Characterization of Polyhydroxyalkanoates.”
 The Second Korea-US Joint Seminar on Bioprocess Technology; Seoul, Korea; December
12-17, 1991; Chairman - Biocatalysis and Enzyme Technology, Speaker - Recent
Advances in Molecular Biology of Amino Acid Producing Corynebacterium.
 MIT Industrial Liaison Program, "The Future of the Pharmaceutical Industry"
Symposium, Emerging Technology”; November 20-21, 1991; Session Chairman.
 International Symposium Europe-USA, "New Frontiers in Science and Engineering in a
European Perspective"; Paris, France; May 27-28, 1991; Organizing Committee.
12

 International Symposium on Biodegradable Polymers; Tokyo, Japan; October 29-31,
1990; Invited Speaker.
 6th International Symposium, Genetics of Industrial Microorganisms; Strasbourg,
Germany; August 12-18, 1990; Invited Speaker.
 SIM Meeting; Orlando, Florida; August 6-10, 1990; Invited Speaker.
 European Society for Animal Cell Technology, 10th Meeting; Production of Biologicals from Animal Cells in Culture Research, Development and Achievements; Palais des
Papes, Avignon, France; May 7-11, 1990; Invited Speaker, "The Role of Oxidation-
Reduction Potential in Monitoring Growth of Cultured Mammalian Cells."
 Cell Culture Engineering II Conference; Santa Barbara, California; December 3-8, 1989;
Chairman.
 NATO Conference; Spain; May 1990; To be published in NATO vol. Kluwer
Publications: “New Biosynth., Biodegrad. Polymers of Ind. Inter. From
Microorganisms”.
 Eighth International Symposium on the Life Sciences, The Taniguchi Foundation; Japan;
October 23-26, 1989; Invited Speaker.
 Animal Cell Reactor Engineering, Short Course; University of Minnesota; May 8-11,
1989; Lecturer.
 AIChE, Biodegradable Polymers; Orlando, Florida; March 18-22, 1990, Chairman.
 Fourth Conference on Genetics of Industrial Microorganisms; Bloomington, Indiana;
Oct. 5-12, 1988; Invited Speaker.
 US/France Biotechnology Planning Committee; Paris, France; May 18-21, 1988.
 US/France Biotechnology Planning Committee; Paris, France; April 15-18, 1987.
 New Technologies for the Food Industry, "Future Impact of Biotechnology on Food
Ingredients and Processing"; Carmel, California; April 6-8, 1988.
 Department of Energy - Division of Materials Science, Workshop on Enzymatic
Synthesis of Materials; Berkeley, California; March 27-30, 1988.
 Engineering Foundation Conference in "Cell Culture Engineering"; January 31 -
February 5, 1988; Co-Chairman.
 Animal Cell Reactor Engineering Course, Swiss Federal Institute of Technology; July 11-
14, 1988; Lecturer.
13

 Animal Cell Reactor Engineering Course; Fluor Daniel Management Development
Center, Greenville, SC; December 14-15, 1987; Lecturer.
 GBF; Braunschweig, Germany; Sept. 16-22, 1987; Invited Speaker, “Biopolymer
Engineering”.
 Technical University, Aachen; Sept. 15, 1987; Invited Speaker, "Biopolymer
Engineering".
 BIO/Technica '87, 3rd International Exhibition & Congress for Biotechnology;
September 22-24, 1987; Lecturer, "Bioreactors for Animal Cell Culture".
 4th European Congress on Biotechnology 1987; Mini-Symposia, "Cloning and
Expression of Amino Acid Biosynthetic Genes in Coryneform Bacteria"; Amsterdam;
June 14-19, 1987.
 BPEC Industrial Consortium, Workshop on "Process Control and Scale-up"; M.I.T.; May
18, 1987.
 Snow Brand Life Sciences Institute; October 1987; Distinguished Lecturer.
 Animal Cell Reactor Engineering, Short Course; University of Minnesota; May 11-14,
1987; Lecturer.
 Biotechnology Process Engineering, M.I.T., Industrial Liaison Program, "Optimization of
Fed-Batch Hybridoma Cultures," October 29-31, 1986, Symposium Chairman and
Participant.
 Animal Cell Reactor Engineering, Short Course; University of Minnesota; October 14-17,
1986; Lecturer.
 Second Conference to Promote Japan/U.S. Joint Project and Cooperation in
Biotechnology; Moriyama, Shiga, Japan; September 27-30, 1986; Presenter and participant.
 Recent Developments in Industrial Polysaccharides: The Impact of Biotechnology and
Advanced Methodologies, An International Workshop; Stevens Institute of Technology,
Hoboken, NJ; August 18-19, 1986; Presenter and participant.
 Biotechnology Process Engineering, M.I.T.; Industrial Liaison Program; October 28-30,
1985; Symposium Chairman and Participant.
 Biotechnology in the Food Processing Industry, An International Symposium; Oct. 7-9,
1985; Minneapolis, MN; Scientific Advisory Committee Member, Invited Speaker.
14

 Defense Advance Research Projects Agency, Mini Workshop on Biotechnology,
"Overview of Biotechnology"; Arlington, VA; February 1985.
 UNIDO, Ad-hoc Expert Group Meeting for the Discussion and Preparation of an
International Collaborative Project on Upgrading the Nutritional Value of Fermented
Cassava Food; March 1985; Vienna, Austria.
 Flanders Technology International '85, Organized by the Government of Flanders and the International Trade Fair of Flanders; Ghent, Belgium; March 1985; Invited Speaker.
 Current Status of Genetic Engineering of Lactobacillus; Mexico; November 26-29, 1984;
Presenter, “Importance of Lactic Acid Fermentation in the Food Industry”.
 1984 Engineering Foundation Conference, Recent Advances in Mammalian Cell Culture;
University College, Galway, Ireland; September 30 - October 5, 1984.
 UNIDO, Biotechnology and Lactic Fermentation: Basic Principles and Applications;
Mexico; November 1984; Co-organizer.
 IV International Biochemical Engineering Conference; Galway, Ireland; September 30 -
October 5, 1984; Participant.
 Recovery of Fermentation Products, January 29 - February 3, 1984; Session Chairman on
Cell Disruption and Harvesting, Presenter – “Genetic Solutions to Cell Disruption
Problems”.
 ASM Annual Meeting, Amino Acid Fermentations; March 1984.
 Seminar/Workshop on Technology Transfer, Management and Development and the
Implications of Newly Emerging Advanced Technologies; "The Effects of Development in Biotechnology on the Third World" and "The Transfer of Biotechnology to the Third
World"; Trinidad and Tobago; November 8-10, 1983.
 "The Future" A Conference on Biomaterials by the United States Navy and Office of
Naval Research and Naval Air Systems Command; September 20, 1983; Chairman.
 1983 Midwest Food Processors Conference; Minneapolis, MN; October 25-26, 1983;
Invited Speaker, "Genetic Engineering as Related to Food Science and Technology - A
Look into the Future”.
 St. John's University, Jamaica NY; September 1983; Invited Speaker “Recent
Development in Biotechnology".
15

 Biotechnology in the Americas: Prospects for Developing Countries, Symposium and
Workshop; "Biotechnological Processes: State-of-the-Art"; San Jose, Costa Rica; May 3-6,
1983.
 AIChE Meeting, The Future Role of Genetic Engineering in Fuels and Petrochemicals;
November 1983; Co-Chairman.
 IFT Annual Meeting, Genetic Engineering in Food Production; "Use of Biotechnology in the Production of Single Cell Protein"; June 19-22, 1983.
 American Society for Microbiology, 83rd Annual Meeting; New Orleans, Louisiana;
March 1983; Invited Speaker "Applications of Bacteria by the Food Industry".
 1982 ASEE Summer School for Chemical Engineering Faculty, "Recombinant DNA
Technology"; Santa Barbara, CA; August 1982.
 Gordon Research Conference, Microbiology Safety of Foods; "Recent Developments in the Genetics for Food Application"; July 1982; Session Chairman.
 Society for Applied Bacteriology, Summer Conference; Loughborough, England; July
1982; Invited speaker, "Heat Damage and Repair in the Bacterial Chromosome and its
Relationship to Cell Viability".
 IVth International Symposium on Genetics of Industrial Microorganisms; June 1882;
Kyoto, Japan.
 The Financial Analysts Federation 1982 Annual Conference; May 1982; Invited Speaker.
 PMA Biological Section's Spring Meeting; March 1982; Scottsdale, Arizona; Guest
Speaker.
 3rd International Symposium of the Korean Society for Applied Microbiology;
Biotechnology Research Dept., Korea Advanced Institute of Science and Technology.
 Offshore Technology Conference; Houston, Texas; May 2-5,1983; Marine Technology
Society Program Committee Member.
 VIth Enzyme Engineering Conference; Kasikojima, Japan; September 20-25, 1981;
Participant.
 Research and Development Associates for Military Food and Packaging Systems, Fall
Meeting; Natick, MA; September 17, 1981; Invited Speaker on "Genetic Engineering:
Future Foods and Agricultural Potentials".
16

 La Asociacion Quimica Argentina and Comision de Investigaciones Cientificas de la
Provincia de Buenos Aires; Buenos Aires, Argentina; August 10-14, 1981; Featured
Lecturer, Advance in Food Microbiology and Applied Microbiology, Short course.
 Jubilee Meeting of the Society for Applied Bacteriology; University of Bristol, England;
July 13-17, 1981; Invited Speaker, "Role of Genetic Engineering and Microbial
Modifications for Production of Food Additives".
 Canadian Society of Microbiologists, 31st Annual Meeting; Ottawa, Ontario, Canada;
June 21-25, 1981; "Hotpack" lecturer, "The Role of Applied Genetics in Single Cell
Protein Production".
 Young Presidents' Organization, Seminar on "Technological Innovations of the 1980's";
Boston, MA; 1981; Invited Speaker on "Potentials of Biotechnology".
 I.T.P. - M.I.T. Program; C.E.P.S.A. Madrid, Spain; March 1981; Presenter of Lectures and
Seminars.
 American Society for Microbiology, Seminar on "Biomass Conversions" at Annual
Meeting; Dallas, Texas; March 2-5, 1981; Invited Speaker.
 Kansas State University, Department of Chemical Engineering; February 26-27, 1981;
Guest Scholar.
 I.T.P. - M.I.T. Program, Lectures on "Bioconversion of Biomass"; Madrid, Spain;
November 17 - 19, 1980; Lecturer.
 I.L.O. Symposium on "Biotechnology: Status and Prospects"; M.I.T.; October 14-15, 1980;
Chairman.
 6th International Fermentation Symposium; London, Ontario, Canada; July 20-25, 1980;
Participant.
 Biochemical Engineering Conference; Henniker, New Hampshire; July 13-18, 1980;
Participant.
 Society of Chemical Industry, Microbiology, Fermentation and Enzyme Technology
Group, and Food Group Symposium on "Recent Developments in Antimicrobial Food
Preservatives"; London, England; December 12, 1979; Invited Speaker.
 US/USSR Joint Working Group on Scientific and Technical Cooperation on the
Production of Substances by Microbiological Means; Symposium on Fundamental of
Microbial Processes; M.I.T.; October 29-31, 1979; Invited Speaker.
17

 People's Republic of China, Peking; May 6-26, 1979; Invited to visit and give lectures at
Institute of Microbiology, Academy of Sciences.
 International Symposium on "Food and Health - Science and Technology"; National
College of Food Technology; University of Reading, Weybridge, England; April 8-12,
1979; Invited Speaker, "Use of Prokaryotic and Eukaryotic Culture Systems for
Examining Biological Activity of Food Constituents".
 American Academy of Microbiology, Ad Hoc Environmental Microbiology Committee
Meeting; Washington, D.C; November 29, 1978.
 M.I.T. - Industrial Liaison Program Symposium, "Cellulosis Biomass: Degradation and
Utilization"; November 9, 1978; Invited Speaker.
 M.I.T. - Industrial Liaison Program; Visitation of nine Japanese companies; September
22-30, 1978; Presenter of Lectures and Seminars.
 I.T.P. - M.I.T. Program; Visitation if Madrid; February 13-26, 1978; Review of food science research program.
 Republic of China/U.S.A. Food Safety Workshop; Taiwan; September 12-14, 1978;
Invited Speaker, “Enteropathogenic Escherichia coli: Epidemiology, Significance and
Genetics of Toxicology".
 M.I.T. - Industrial Liaison Program; Visitation of Japan, Tokyo, and Osaka; June 27- July
5, 1978; Presentation of Lectures and Seminars at 13 companies.
 American Society for Microbiology, Fall Meeting, Syracuse, New York, November 4,
1977, "Single Cell Protein", Special Lecturer.
 International Atomic Energy Agency, Technical Committee Meeting on
"Radiosensitivity of Pathogenic Microorganisms in Sewage and Wastes"; Uppsala,
Sweden; August 15-17, 1977; "Preliminary Finding on Genetic Mapping of a Highly
Radio-Resistant Mutant of Salmonella typhimurium," Invited Speaker.
 European Society of Nuclear Methods in Agriculture, VIIIth Annual Meeting; Uppsala,
Sweden; August 19 - September 2, 1977; "Experience at Deer Island with Electron
Disinfection of Sludge at High Flow Rates", Invited Speaker.
 US/USSR Conference on Mechanisms and Kinetics of Uptake and Utilization of
Substances of Single-Cell Protein Production; Moscow-Pushchino; June 4-11, 1977;
"Application of Temperature-Sensitive Mutants for Single-Cell Protein Production",
Invited Speaker.
18

 Third National Conference on Sludge Management Disposal and Utilization; Miami,
Florida; December 14-16, 1976; “Biological Effects of Irradiation with High Energy
Electrons”, Invited Speaker.
 IFT meeting; St. Louis, MO; January 1977; Program committee.
 IFT Meeting-in-Miniature; Cresskill, N.J.; January 1977; "The Microbiological Aspects
Food Product Safety”, Invited Speaker.
 International Atomic Energy Agency Conference on "Radiation for a Clean
Environment"; Munich; 1975; Participant.
 U.S.-U.S.S.R. Conference on Single-Cell Protein; M.I.T. Cambridge, MA.; 1976;
Participant.
 5th International Fermentation Symposium; West Berlin; 1976; Participant.
 International Congress on Intermediate Moisture Foods; Weybridge, England; April
1976; Invited Speaker.
 Lecturer at Northeastern University; 1970 - 1976.
 Food Microbiology Research Conference; Illinois; 1972 – 1976; Invited Speaker.
 Japan-U.S.A. Conference on Freezing and Freeze-Drying; West Virginia; 1972; Invited
Speaker.
 4th International Fermentation Symposium; Japan; 1972; Participant.
 Xth International Congress for Microbiology; Mexico City, Mexico; 1970.
 Institute of Food Technology Symposium - The Selection of Microorganisms by Food
Processing; 1969; Chairman and Organizer.
 American Society of Microbiology, Round Table- Significance of Organisms Commonly
Neglected in Food Microbiology; 1968; Chairman and Organizer.
 American Society of Microbiology, Round Table - Microbial Damage Incurred by Food
Processing and the Recovery Process; 1967; Chairman and Organizer.
T
HESES
S
UPERVISION
 Conjugation of Extrachromosomal Replicons of Rhodococcus erythropolis AN12. J.C.
Yang, May 2006.
19

 Control of Product Molecular Weight in the Enzymatic Synthesis of a Biodegradable
Polyester. A.G. Lawrence, April 2006.
 Molecular Weight Formation in Polyhydroxybutyrate Fermentations. B.R. Waters,
September 2005.
 Mechanistic Investigation of Polyhydroxybutyrate (PHB) Synthases and Elucidation of
PHB Biosynthesis and Degradation Process in Wautersia eutropha H16. J. Tian, February
2005.
 Integrated Microbioreactors for Rapid Screening and Analysis of Bioprocesses. A.
Zanzotto, February 2005.
 Aromatic Hydrocarbon Metabolism by Rhodococcus sp. I24: Computational, Biochemical and Transcriptional Analysis. J. Parker, January 2005.
 Lipopolysaccharide, K antigen, and Other Components of the Cell Surface Important for
S. meliloti-Alfalfa Symbiosis. G. Campbell, May 2001.
 The Necessity of Debranching in Starch Biosynthesis. E. Shaw, August 1999.
 Molecular Genetic Analysis of Indene Bioconversion in Rhodococcus Strain I24. S.L.
Treadway, April 1999.
 Branchpoint Flux Analysis in the L-lysine Pathway of Corynebacterium glutamicum. C.A.
Shaw-Reid, June 1997.
 Investigation of Carbon Fluxes in Central Metabolic Pathways of Corynebacterium
glutamicum. S.M. Park, March 1996.
 Transcriptional Regulation in Corynebacterium glutamicum, M.M. McCormick, January
1996.
 Metabolic Engineering of Amino Acid Production in Corynebacterium glutamicum, G.E.
Colón, June 1995.
 Genetic and Biochemical Analysis of Corynebacterium glutamicum Fructose-1,6biophosphate Aldolase, C. von der Osten, June 1991.
 Gene Regulation During T-Cell Activation, V. Valge-Archer, December 1990.
 Control Processes for Cultivation of Mammalian Cells, C. Hwang, June 1990.
 Ammonia Toxicity in Mammalian Cell Culture, E. Adema, September 1989.
20

 Development of Recombinant DNA Technology for Corynebacterium glutamicum:
Isolation and Characterization of Amino Acid Biosynthesis Genes, M. Follettie, June
1989.
 A Recombinant DNA Approach to the Design and Synthesis of Novel Polysaccharides,
D.D. Easson, August 1987.
 Controlled Biosynthesis of Yeast Glucans, S. Jamas, June 1987.
 Development of Mathematical Descriptions of Hybridoma Metabolic Kinetics for
Optimization and Design of Fed-Batch Bioreactors, M. Glacken, March 1987.
 Biological Formation of Acrylic Acid by Clostridium propionicum, M. Akedo, May 1983.
 An Experimental Study in the Use of Instrumentation to Analyze Metabolism and
Product Formation in Cell Culture, R. Fleischaker, May 1982.
 The Physiology of Clostridium thermocellum. The Toxicity of Its Fermentation Products in Relation to the Energy Metabolism, A. Herrero-Molino, May 1981.
 Diffusion Bioassay for the Quantitative Determination of Mutagenicity of Carcinogens,
T.E. Awerbuch, May 1979.
 The Dynamics of Streptococcus mutans Soluble and Insoluble Dextransucrase Activities,
T. Montville, May 1979.
 Rate Zonal Density Gradient Ultracentrifugation Analysis of Repair of Radiation
Damage to the Folded Chromosome of Escherichia coli, K. Ulmer, April 1978. (Ph.D. in
Biology)
 Minimal Medium Recovery of Heated Salmonella typhimurium, R.F. Gomez, May 1973.
 Genetic Studies of Radio-Resistance Mutants of Salmonella typhimurium, S.I. Ibe, May
1973.
 The Role of Radiosensitization by Diacetyl on Microorganisms, C.H. Tzeng, May 1973.
 The Use of Continuous Culture and an Enamel Dissolution Assay in Studying the
Relationship Between Streptococcus mutans and Dental Caries, G.E. White, May 1973.
 The Mechanisms of Radioresistance in Mutants of Salmonella typhimurium, R. Davies,
May 1971.
 Characterization of Injury to Salmonella typhimurium Subject to Freeze-Drying, P.P.
Lewicki, May 1969.
21


Production of Polyhydroxyalkanoates under Phosphate Limitation from Palm Oil by
Recombinant Strains of Ralstonia eutropha. Sebastian Riedel, February 2010.

Polyhydroxyalkanoate Production in Emulsified Palm Oil Fermentations by
Recombinant Strains of Ralstonia eutropha. Florian Hübner, May 2009.
 Improvement of Xylose Metabolism in the Actinomycete Rhodococcus opacus PD630. Jil
Ulrich, May 2009.
 Genomics Research and Cultivating Serendipity in Pharmaceutical Drug Discovery:
Assessing the Competitiveness of R&D Productivity between the West and Asia. Trent
Yen-wei Lu, June 2007.
 Polyhydroxyalkanoate production from palm oil by Ralstonia eutropha H16. Stefan
Risch, October 2006.
 Genetic basis of secondary metabolite biosynthesis Rhodococcus fasciens 307CO. Annika
Weiz, October 2006.
 Engineering a Rhodococcus strain for tocotrienol biosynthesis. Alina Grigorescu, July
2004.
 Dynamics of gene transcription during Poly[D-(-)-3-Hydroxybutyrate] (PHB) production and utilization in Ralstonia eutropha H16. Joerg Schoenheit, May 2004.
 Indene Bioconversion by Gene Products of Rhodococcus sp. Strain I24. Annett Reichel,
November 2002.
 Identification and Deletion of the PhaZ2 Gene, which Codes for an Intracellular Poly[D-
(-)-3-Hydroxybutyrate] (PHB) Depolymerase in Ralstonia eutropha H16. Joachim
Lupberger, November 2002.
 Impact of Amino Acid Overproduction on Gene Expression in Corynebacterium
glutamicum. H. von Keyserling, May 2002.
 Monitoring gene expression in Rhodococcus erythropolis AN12 using cDNA microarrays.
S. Tomic, November 2001.
 Validation of DNA Microarrays and Comparative Studies of Gene Expression and
Enzyme Activity. C. Glanemann, August 2001.
22

 Using Human Metabolic Enzyme Profiling as an Innovative Technology in the Drug
Development Process. H. Sato, June 2000.
 Development of an Enzymatic Assay for the Measurement of Pyruvate Carboxylase
Activity in Corynebacteriam glutamicum during Lysine Fermentation. E. Kielhorn, July
1999.
 The Development of a Cloning System for Corynebacterium glutamicum. M. Yoshihama,
January 1985.
 The Effect of Ethanol on Glycolytic Enzyme of Clostridium thermocellum, L. M. Mills,
May 1983.
 The Production and Regulation of Cysteine Desulfhydrase in Enterobacter cloacase, M.T.
King, May 1983.
 The Effect of  -Glucan Structure on the Rheological Properties of Yeast Cell Walls, S.
Jamas, May 1983.
 The Characterization of a Temperature-Sensitive Mutant of Saccharomyces cerevisiae for its Application to SCP Prod., H.M. Diaz, May 1981.
 The Application of Temperature-Sensitive Mutants for SCP Production, Y. Miyasaka,
May 1979.
 Analysis of the Alkylation Damage Done to Folded Chromosome of E. coli, R. Saunder,
May 1978.
 Purification and Characterization of the RNA Degrading System of Candida lypolytica, J.
Hunt, May 1977.
 High Energy Electron Irradiation of Waste Water and Residuals, D. Shah, May 1976.
 Factor Affecting Dextransucrase Production in Streptococcus mutans PR89, C. Schein,
May 1976.
 Viability of Staphylococcus aureus in Intermediate Moisture Foods, M. Plitman, May 1973.
 The Effects of Heating on Serum Proteins and on the Inactivation of Echo-7 Virus in
Serum, W. Walker, May 1972.
 Utilization of L(-)-Glucose by Naturally Occurring Microorganisms, R. Fewkes, May
1972.
 Mechanism of RNA Hydrolysis in Candida utilis, S. Ohta, May 1970.
23

 Decreasing the Nucleic Acid Content of Candida cells by the Action of Bovine
Pancreative Ribonuclease A, A. Castro, May 1970.
C URRENT T EACHING A CTIVITIES AT M.I.T.
7.13 Experimental Microbial Genetics
Subject uses molecular genetics to examine how Gram-positive and Gram-negative bacteria can be used in bioconversion processes, for example, to synthesize precursors to the drug Crixivan TM , a potent inhibitor of HIV replication. Techniques used include a plasmid manipulation, genetic complementation, mutagenesis, PCR, and DNA sequencing. (Taught with P. Lessard)
7.18 Topics in Experimental Biology
Independent experimental study under the direction of a member of the Biology
Department faculty. Allows students with a strong interest in independent research to fulfill the project laboratory requirement for the Biology Department Program in the context of a research laboratory at MIT. The research should be a continuation of a previous project. Written and oral presentation of the research results is required.
Journal club discussions are used to help students evaluate and write scientific papers. Instruction and practice in written and oral communication is provided.
(Taught with K. Pepper)
7.40 Biotechnology: Engineering of Macromolecules
Fundamentals of genetics and biochemical principles for the synthesis, design, and engineering of biopolymers such as polyesters and polysaccharides and including principles of underlying structure-function properties of biopolymers. Topics include conformation analysis and molecular properties of polymer chains in solution. (Taught with C.K. Rha)
15.123 Dynamics of Biomedical Technologies
Examines interrelationships between life science and technology developments in the context of six dynamic forces affecting the biomedical industrial sector.
Considers these interrelationships through close investigation of one science or technology platform each semester. Case studies, upper-level executive presentations, and student group exercises focus discussion and in-depth analysis
24

on industry structure, risk and economics, cost drivers and financing, markets, consumers and patients, the rapid evolution of related science and technology, public policy, accountability and ethics. (Taught with T.F. Dagi, F. Douglas)
15.136 Principles and Practice of Drug Development
Description and critical assessment of the major issues and stages of developing a pharmaceutical or biopharmaceutical. Drug discovery, preclinical development, clinical investigation, manufacturing and regulatory issues considered for small and large molecules. Economic and financial considerations of the drug development process. Multidisciplinary perspective from faculty in clinical; life; and management sciences; as well as industry guests. (Taught with S. Finkelstein, R. Rubin, T. Allen,
C. Cooney)
7.549 Case Studies and Strategies in Drug Discovery and Development
The stages in drug discovery and development begin with target identification and end with the submission of preclinical and clinical data to the regulatory authorities.
Following identification of a lead compound, there is optimization of structures for pharmaceutical properties, bioavailability, and safety. Subject relies on actual cases of drug development. A major goal is to analyze the cases and determine how the discovery and development process might be influenced by new and future technologies.
P
UBLICATIONS
:
322.
Puglisi, E., M.J. Cahill, P.A. Lessard, E. Capri, A.J. Sinskey, J.A.C. Archer, and P.
Boccazzi. 2010. Transcriptional Response of Rhodococcus aetherivorans
I24 to Polychlorinated Biphenyl-Contaminated Sediments. Microb. Ecol. E-pub ahead of print.
321. Brigham, C.J. and A.J. Sinskey. 2010. Optimization of growth media components for polyhydroxyalkanoate (PHA) production from organic acids by
Ralstonia eutropha. Appl. Microbiol. Biotechnol. E-pub ahead of print.
320. Kurosawa, K., P. Boccazzi, N. de Almeida, and A.J. Sinskey. 2010. High-celldensity batch fermentation of Rhodococcus opacus PD630 using a high glucose concentration for triacylglycerol production. J. Biotechnol. 147:212-218.
25

319. Willis, L.B., G.M. York, P.A. Lessard, Y.B. Jo, O.A. Rasid, M.A.A. Manaf, C. Park, and A.J. Sinskey. 2008. Reagents for generation and analysis of bioplastic producing plants. J. Oil Palm Research S2:56-68.
318. Willis, L.B., W.S.W. Omar, R. Sambanthamurthi, and A.J. Sinskey. 2008. Nonradioactive assay for acetyl CoA carboxylase activity. J. Oil Palm Research S2:30-
36.
317. Omar, W.S.W., L.B. Willis, C. Rha, A.J. Sinskey, U.S. Ramli, A.M.M. Yunus,
G.K.A. Parveez, and R. Sambanthamurthi. 2008. Isolation and utilization of acetyl-CoA carboxylase from oil palm (Elaeis guineensis) mesocarp. J. Oil Palm
Research S2:97-107.
316. Parveez, G.K.A., B. Bohari, N.H. Ayub, A.M.M. Yunus, O.A. Rasid, A.T. Hashim,
Z. Ishak, M.A.A. Manaf, A.K. Din, G. York, Y.B. Jo, and A.J. Sinskey. 2008.
Transformation of PHB and PHBV genes driven by maize ubiquitin promoter into oil palm for the production of biodegradable plastics. J. Oil Palm Research
S2: 77-86.
315. Choi, D.S., M.H.C. Andrade, L.B. Willis, C. Cho, J. Schoenheit, P. Boccazzi, R.
Sambanthamurthi, A.J. Sinskey, and C.K. Rha. 2008. Effect of Agitation and
Aeration on Yield Optimization of Oil Palm Suspension Culture. J. Oil Palm
Research Special Issue 1:23-34.
314. Rafat, M., K.W. Fong, A. Goldsipe, B.C. Stephenson, S.T. Coradetti, T.G.
Sambandan, A.J. Sinskey, and C.K. Rha. 2008. Association (micellization) and partitioning of aglycon triterpenoids. J. Colloid Interface Science. 325:324-330.
313. Abdullah, M.A., A. Rahmah, A.J. Sinskey, and C.K. Rha. 2008. Cell Engineering and Molecular Pharming for Biopharmaceuticals. Open Med. Chem. J. 2:49-61.
312. Willis, L.B., P.A. Lessard, J.A Parker, X.M. O’Brien, and A.J. Sinskey. 2008.
Functional annotation of oil palm genes using an automated bioinformatics approach. J. Oil Palm Research 1:35-43.
311. Willis, L.B., G.A. Gil, H.L.T. Lee, D.S. Choi, J. Schoenheit, R.J. Ram, C. Rha, and
A.J. Sinskey. 2008. Application of spectroscopic methods for the automation of oil palm culture. J. Oil Palm Research 1:1-13.
310. Thiers, F.A., A.J. Sinskey, and E.R. Berndt. 2008. Trends in the globalization of clinical trials. Nat. Rev. Drug Discovery 7:13-14.
309. Kurosawa, K., I. Ghiviriga, T.G. Sambandan, P.A. Lessard, J.E. Barbara, C.K. Rha, and A.J. Sinskey. 2008. Rhodostreptomycins, Antibiotics Biosynthesized
Following Horizontal Gene Transfer from Streptomyces padanus to Rhodococcus
fascians. J. Am. Chem. Soc. 130(4):1126-7.
26

308. Govindan, G., T.G. Sambandan, M. Govindan, A. Sinskey, J. Vanessendelft, I.
Adenan, and C.K. Rha. 2007. A Bioactive Polyacetylene Compound Isolated from Centella asiatica. Planta Med. 73(6):597-9.
307. Zhang, Z., P. Boccazzi, H.G. Choi, G. Perozziello, A.J. Sinskey, and K.F. Jensen.
2006. Microchemostat-microbial continuous culture in a polymer-based, instrumented microbioreactor. Lab Chip. 6(7):906-913.
306. Yang, J.C., P.A. Lessard, N. Sengupta, S.D. Windsor, X.M. O’Brien, M. Bramucci,
J.F. Tomb, V. Nagarajan, and A.J. Sinskey. 2007. TraA is required for megaplasmid conjugation in Rhodococcus erythropolis AN12. Plasmid. 57(1):55-
70.
305. Yang, J.C., P.A. Lessard, and A.J. Sinskey. 2007. Characterization of the mobilization determinants of pAN12, a small replicon from Rhodococcus
erythropolis AN12. Plasmid. 57(1):71-81.
304. Cho, C.W., D.S. Choi, M.H. Cardone, C.W. Kim, A.J. Sinskey, and C. Rha. 2006.
Glioblastoma cell death induced by Asiatic acid. Cell Biol. Toxicol. 22(6):393-
408.
303. Boccazzi, P., Z. Zhang, K. Kurosawa, N. Szita, S. Bhattacharya, K. Jensen, and
A.J. Sinskey. 2006. Differential gene expression profiles and real-time measurements of growth parameters in Saccharomyces cerevisiae grown in microliter scale bioreactors equipped with internal stirring. Biotechnol. Prog. 22:710-
717.
302. Zhang, Z., N. Szita, P. Boccazzi, A.J. Sinskey, and K.F. Jensen. 2006. A wellmixed, polymer-based microbioreactor with integrated optical measurements.
Biotechnol. Bioeng. 93(2):286-96.
301. Lee, H.L.T., P. Boccazzi, R.J. Ram, and A.J. Sinskey. 2006. Microbioreactor arrays with integrated mixers and fluid injectors for high-throughput experimentation with pH and dissolved oxygen control. Lab Chip. 6(9):1229-
1235.
300. Plaggenborg, R., J. Overhage, A. Loos, J.A.C. Archer, P. Lessard, A.J. Sinskey, A
Steinbüchel, and H. Priefert. 2006. Potential of Rhodococcus strains for biotechnological vanillin production from ferulic acid and eugenol. Appl.
Microbiol. Biotechnol. 72(4):745-755.
290. Kurosawa, K., V.P. Bui, J.L. Vanessendelft, L.B. Willis, P.A. Lessard, I. Ghiviriga,
T.G. Sambandan, C.K. Rha, and A.J. Sinskey. 2006. Characterization of
Streptomyces MITKK-103, a newly isolated actinomycin X(2)-producer. Appl.
Microbiol. Biotechnol. 72(1):145-54.
27

289. Zanzotto, A, P. Boccazzi, N. Gorret, T.K. Van Dyk, A.J. Sinskey, and K.F. Jensen.
2006. In situ measurement of bioluminescence and fluorescence in an integrated microbioreactor. Biotechnol. Bioeng. 93(1):40-47.
288. Stallings, S., A.J. Sinskey, and S.N. Finkelstein. 2005. Considerations in the
Economic Assessment of the Value of Molecular Profiling. In: Surrogate Tissue
Analysis: Genomic, Proteomic, and Metabolomic Approaches. Burczynski, M.E. and Rockett, J.C. (eds.), CRC Press Taylor & Francis Group: Boca Raton, FL. pp.
263-274.
287. Abdullah, M.A., N.H. Lajis, A.M. Ali, M. Marziah, A.J. Sinskey, and C. Rha.
2005. Issues in Plant Cell Culture Engineering for Enhancement of Productivity.
Developments in Chemical Engineering & Mineral Processing – The
Australasian Research Journal. 13(5/6):573-587.
286. Sinskey, A.J., S.N. Finkelstein, and S.M. Cooper. 2005. A Cure for Multiple
Sclerosis in Our Lifetime? Pharmaceutical Discovery. 5(6):40-43.
285. Tian, J., A.J. Sinskey, and J. Stubbe. 2005. Class III Polyhydroxybutyrate
Synthase: Involvement in Chain Termination and Reinitiation. Biochemistry.
44(23):8369-8377.
284. Stubbe, J., J. Tian, A. He, A.J. Sinskey, A. Lawrence, and P. Liu. Nontemplatedependent polymerization processes: Polyhydroxyalkanoate Synthases as a
Paradigm. 2005. Annu. Rev. Biochem. 74:433-480.
283. Sinskey, A.J., S.N. Finkelstein, and S.M. Cooper. 2005. The Consequences of
Limiting Stem Cell Research: Health and Economic Considerations.
Pharmaceutical Discovery. 5(4):22-24.
282.
Lawrence, A.G., J. Schoenheit, A. He, J. Tian, P. Liu, J. Stubbe, and A.J. Sinskey.
2005. Transcriptional analysis of Ralstonia eutropha genes related to poly-(R)-3hydroxybutyrate homeostasis during batch fermentation. Appl. Microbiol.
Biotechnol. 68(5):663-72.
281. Boccazzi, P., A. Zanzotto, N. Szita, S. Bhattacharya, K.F. Jensen, and A.J. Sinskey.
2005. Gene expression analysis of Escherichia
coli grown in miniaturized bioreactor platforms for high-throughput analysis of growth and genomic data.
Appl. Microbiol. Biotechnol. 68:518-532.
280. Szita, N., P. Boccazzi, Z. Zhang, P. Boyle, A.J. Sinskey and K.F. Jensen. 2005.
Development of a Multiplexed Microbioreactor System for High-Throughput
Bioprocessing. Lab Chip. 5(8):819-826.
279. Lawrence, A.G., J. Choi, C. Rha, J. Stubbe, and A.J. Sinskey. 2005. In vitro analysis of the chain termination reaction in the synthesis of poly-(R)-b-
28

hydroxybutyrate by the Class III synthase from Allochromatium vinosum.
Biomacromolecules. 6(4):2113-2119.
278. Tian, J., A. He, A.G. Lawrence, P. Liu, N. Watson, A.J. Sinskey, and J. Stubbe.
2005. Analysis of Transient Polyhydroxybutyrate Production in Wautersia
eutropha H16 by Quantitative Westerns and Transmission Electron Microscopy.
J. Bacteriol. 187(11):3825-3832.
277. Tian, J., A.J. Sinskey and J. Stubbe. 2005. Kinetic Studies of
Polyhydroxybutyrate Granule Formation in Wautersia eutropha H16 By
Transmission Electron Microscopy. J. Bacteriol. 187(11):3814-3824.
276. Tian, J., A.J. Sinskey, and J. Stubbe. 2005. Detection of Intermediates from the
Polymerization Reaction Catalyzed by a D302A Mutant of Class III
Polyhydroxyalkanoate (PHA) Synthase. Biochemistry. 44(5):1495-1503.
275. Lawrence, A.G., J. Schoenheit, A. He, J. Tian, P. Liu, J. Stubbe, and A.J. Sinskey.
Time-resolved expression profiling of Wautersia eutropha genes related to poly-
(R)-hydroxybutyrate homeostasis during batch fermentation. Submitted.
274. Finkelstein, S.N., A.J. Sinskey, and S.M. Cooper. 2004. Biobanks: Will They Help
Promote the Genomics Revolution? Pharmaceutical Discovery. 4(9):20-24.
273. Sinskey, A.J., S.N. Finkelstein, and S.M. Cooper. 2004. Medical Imaging in Drug
Discovery, Part III. PharmaGenomics. 4(5):18-22.
272. Lessard, P.A., X.M. O’Brien, D.H. Currie, and A.J. Sinskey. 2004. pB264, a small, mobilizable, temperature sensitive plasmid from Rhodococcus. BMC Microbiol.
4(1):15-28.
271. Sinskey, A.J., S.N. Finkelstein, and S.M. Cooper. 2004. Medical Imaging in Drug
Discovery, Part II. PharmaGenomics. 4(4):20-24.
270. Sinskey, A.J., S.N. Finkelstein, and S.M. Cooper. 2004. Medical Imaging in Drug
Discovery, Part I. PharmaGenomics. 4(3):20-26.
269. Sinskey, A.J., S.N. Finkelstein, and S.M. Cooper. 2004. The Question of
Compliance. PharmaGenomics. 4(1):16-19.
268. Willis L.B., P.A. Lessard, and A.J. Sinskey. 2004. Production of threonine and branched chain amino acids in Corynebacterium glutamicum. In: Handbook of
Corynebacterium glutamicum. Eggeling, L. and Bott, M. (eds.), CRC Press, Boca
Raton. In Press.
267. Choi, H.-G., P. Boccazzi, A.J. Sinskey, P.E. Laibinis, and K.F. Jensen. Surface modification of poly(methyl methacrylate) for controlling cell adhesion.
Submitted to ACS Polymer Preprint.
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266. Zanzotto, A., N. Szita, P. Boccazzi, P. Lessard, A.J. Sinskey, and K.F. Jensen.
2004. Membrane-aerated microbioreactor for high-throughput bioprocessing.
Biotechnol. Bioeng. 87(2):243-254.
265. Gorret, N., S.K. bin Rosli, S.F. Oppenheim, L.B. Willis, P.A. Lessard, C. Rha, and
A.J. Sinskey. 2004. Bioreactor culture of oil palm (Elaeis guineensis) and effects of nitrogen source, inoculum size, and conditioned medium on biomass production. J. Biotechnol. 108:253-263.
264. Lee, H.L.T., P. Boccazzi, N. Gorret, R.J. Ram, and A.J. Sinskey. 2004. In situ bioprocess monitoring of Escherichia coli bioreactions using Raman spectroscopy.
Vibrational Spectroscopy 35:131-137.
263. Sinskey, A.J., S.N. Finkelstein, and S.M. Cooper. 2003. See you in December?
PharmaGenomics. 3(8):24-25.
262. Singh, R., P.A. Lessard, S.G. Tan, J.M. Panandam, A. Sinskey, and S.C. Cheah.
2003. Preliminary attempts at the construction of large insert DNA libraries of oil palm (Elaeis guineensis Jacq.) J. Oil Palm Research. 15(1):12-20.
261. Lee, H.L.T, P. Boccazzi, N. Gorret, R.J. Ram, and A.J. Sinskey. 2003. Raman spectroscopy for in-situ bioprocess monitoring. Proceedings of the Second
International Conference on Advanced Vibrational Spectroscopy, Aug. 24-29,
Nottingham, UK.
260. Choi, H.-G., Z. Zhang, P. Boccazzi, P.E. Laibinis, A.J. Sinskey, and K.F. Jensen.
2003. Poly(ethylene glycol) (PEG) V modified poly (dimethysiloxane) (PDMS) for protein and cell- resistant surfaces in microbioreactor. Proceedings of
MicroTAS 2003 – 7 th International Conference on Miniaturized Chemical and
Biochemical Analysis Systems, M.A. Northrup, K.F. Jensen and D.J. Harrison
(Eds.), Squaw Valley, CA. Tranducers Research Foundation. pp. 1105-1108.
259. Zhang, Z., N. Szita, P. Boccazzi, A.J. Sinskey, and K.F. Jensen. 2003. Monitoring and control of cell growth in fed-batch microbioreactors. Proceedings of
MicroTAS 2003 – 7 th International Conference on Miniaturized Chemical and
Biochemical Analysis Systems, M.A. Northrup, K.F. Jensen and D.J. Harrison
(Eds.), Squaw Valley, CA. Tranducers Research Foundation. pp. 765-768.
258. Szita, N., A. Zanzotto, P. Boccazzi, A.J. Sinskey, M.A. Schmidt, and K.F. Jensen.
2002. Monitoring of cell growth, oxygen and pH in microfermentors. In: Micro
Total Analysis Systems 2002. Y. Baba, S. Shoji, and A. van den Berg, (eds),
Dordrecht: Kluwer Academic. pp. 7-9.
257. Finkelstein, S.N., A.J. Sinskey, and S.M. Cooper. 2003. Getting Personal with
Pain. PharmaGenomics. 3(6):18-21.
30

256. An, G.-H. and A.J. Sinskey. 2003. Accumulation of Isoleucine Intermediates in the Isoleucine Producing Recombinant of Corynebacterium lactofermentum ATCC
21799. Food Sci. Biotechnol. 12:137-141.
255. Finkelstein, S.N., A.J. Sinskey, and S.M. Cooper. 2003. A Public/Private
Partnership for Dual-Use Antibiotics. PharmaGenomics. 3(3):18-22.
254. York, G.M., J. Lupberger, J. Tian, A. Lawrence, J. Stubbe, and A.J. Sinskey. 2003.
Ralstonia eutropha H16 Encodes Two and Possibly Three Intracellular Poly[D-(-)-
3-hydroxybutyrate] (PHB) Depolymerase Genes. J. Bacteriol. 185(13):3788-3794.
253. Ozminkowski, R.J., W.D. Marder, K. Hawkins, S. Wang, S.C. Stallings, S.N.
Finkelstein, A.J. Sinskey, and D. Wierz. 2004. The Use of Disease-Modifying
New Drugs for Multiple Sclerosis Treatment in Private-Sector Health Plans.
Clin. Ther. 26(8):1341-1354.
252. Stallings, S.C., D. Huse, S.N. Finkelstein, W.H. Crown, W.P. Witt, J. Maguire, A.J.
Hiller, A.J. Sinskey and G.S. Ginsburg. 2006. A Framework to Evaluate the
Economic Impact of Pharmacogenomics. Pharmacogenomics 7(6):853-862.
251. Sinskey, A.J., S.N. Finkelstein, and S.M. Cooper. 2002. Getting to “Rational”
Drug Design — at Last. PharmaGenomics. 2(6):18-22.
250. Finkelstein, S.N., A.J. Sinskey, and S.M. Cooper. 2002. The Coming Paradigm
Shift in Pharmaceuticals. PharmaGenomics 2(5):26-28.
249. Osman, A., B. Jordan, P.A. Lessard, A.J. Sinskey, C. Rha, and D.E. Housman.
2003. Genetic diversity of Eurycoma longifolia inferred from single nucleotide polymorphisms. Plant Physiol. 131(3):1294-1301.
248. Sinskey, A.J., S.N. Finkelstein, and S.M. Cooper. 2002. The Promise of Protein
Microarrays. PharmaGenomics 2(4):20-24.
247. Sinskey, A.J., S.N. Finkelstein, and S.M. Cooper. 2002. Integrating the Science and Technology Revolutions. PharmaGenomics 2(3):18-21.
246. Coldren, C.D., P. Hashim, J.M. Ali, S. Oh, A.J. Sinskey, C. Rha. 2003. Gene expression changes in the human fibroblast induced by Centella asiatica triterpenoids. Planta Med. 69(8):725-32.
245. O’Brien, X.M., J.A. Parker, P.A. Lessard, and A.J. Sinskey. 2002. Engineering an indene bioconversion process for the production of cis-aminoindanol: a model system for the production of chiral synthons. Appl. Microbiol. Biotechnol. 59(4-
5):389-399.
244. Glanemann, C., A. Loos, N. Gorret, L.B. Willis, X.M. O’Brien, P.A. Lessard, and
A.J. Sinskey. 2003. Disparity between changes in mRNA abundance and
31

enzyme activity in Corynebacterium glutamicum: implications for DNA microarray analysis. Appl. Microbiol. Biotechnol. 61:61-68.
243. Kwok, S., S-Y Chang, A.J. Sinskey, and A. Wang. 1995. Design and use of mismatched and degenerate primers. In: Dieffenbach CW, PCR primer: a laboratory manual. Dveksler, G.S. (eds.), Cold Spring Harbor Laboratory Press:
Cold Spring Harbor, NY. pp. 143-155.
242. Stafford, D.E., K.S. Yanagimachi, P.A. Lessard, S.K. Rijhwani, A.J. Sinskey, and
G. Stephanopoulos. 2002. Optimizing bioconversion pathways through systems analysis and metabolic engineering. Proc. Natl. Acad. Sci. 99(4):1801-1806.
241. Sang, J.S., K.D. Snell, B.W. Kim, C.K. Rha, and A.J. Sinskey. 2001. Increased poly -hydroxybutyrate (PHB) chain length by the modulation of PHA synthase activity in recombinant Escherichia coli. Biotechnol. Lett. 23:2057-2061.
240. Priefert, H. X.M. O’Brien, P.A. Lessard, A.F. Dexter, E.E. Choi, S. Tomic, G.
Nagpal, J.J. Cho, M. Agosto, L. Yang, S.L. Treadway, L. Tamashiro, M. Wallace, and A.J. Sinskey. 2004. Indene bioconversion by a toluene-inducible dioxygenase of Rhodococcus sp.I24. Appl. Microbiol. Biotechnol. 65(2):168-76 .
239. Nielsen, U.B., M.H. Cardone, A.J. Sinskey, G. MacBeath, and P.K. Sorger. 2003.
Profiling receptor tyrosine kinase activation using antibody microarrays. PNAS.
100(16):9330-9335.
238. Yuan, W., Y. Jia, J. Tian, K.D. Snell, U. Muh, A.J. Sinskey, R.H. Lambalot, C.T.
Walsh, and J. Stubbe. 2001. Class I and III Polyhydroxyalkanoate Synthases from Ralstonia eutropha and Allochromatium vinosum: Characterization and
Substrate Specificity Studies. Arch. Biochem. Biophys. 394(1):87-98.
237. Lessard, P.A., H. Kulaveerasingam, G.M. York, A. Strong, and A.J. Sinskey.
2002. Manipulating Gene Expression for the Metabolic Engineering of Plants.
Metab. Eng. 4:67-79.
236. Lee, S.-P., T.-R. Kim, and A.J. Sinskey. 2000. Cloning and Sequencing of the
Gene Involved in Morphological Change of Zoogloea ramigera 115SLR. J.
Microbiol. Biotechnol. 10(2):161-168.
235. Stallings, S.C., R.H. Rubin, T.J. Allen, C.L. Cooney, S.N. Finkelstein, and A.J.
Sinskey. 2002. Technological Innovation in Pharmaceuticals. PharmaVentures:
Pharmaceutical Discovery and Development 2 nd ed. pp. 12-16.
234. York, G.M., J. Stubbe, and A.J. Sinskey. 2002. The Ralstonia eutropha PhaR
Protein Couples Synthesis of the PhaP Phasin to the Presence of
Polyhydroxybutyrate in Cells and Promotes Polyhydroxybutyrate Production. J.
Bacteriol. 184(1):59-66.
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233. York, G.M., B.H. Junker, J. Stubbe, and A.J. Sinskey. 2001. Accumulation of the
PhaP Phasin of Ralstonia eutropha is Dependent on Production of
Polyhydroxybutyrate in Cells. J. Bacteriol. 183(14):4217-4226.
232. Guillouet, S., A.A. Rodal, G.-H. An, N. Gorret, P.A. Lessard, and A.J. Sinskey.
2001. Metabolic redirection of carbon flow toward isoleucine by expressing a catabolic threonine dehydratase in a threonine overproducing Corynebacterium
glutamicum. Appl. Microbiol. Biotechnol. 57:667-673.
231. Jia, Y., W. Yuan, J. Wodzinska, C. Park, A.J. Sinskey, and J. Stubbe. 2001.
Mechanistic Studies on Class I Polyhydroxybutyrate (PHB) Synthase from
Ralstonia eutropha: Class I and III Synthases Share a Similar Catalytic
Mechanism. Biochemistry 40(4):1011-1019.
230. York, G.M., J. Stubbe, and A.J. Sinskey. 2001. New Insight into the Role of the
PhaP Phasin of Ralstonia eutropha in Promoting Synthesis of
Polyhydroxybutyrate. J. Bacteriol. 183(7):2394-2397.
229. Stafford, D.E., P.A. Lessard, A.J. Sinskey, and G. Stephanopoulos. Metabolic engineering of indandiol synthesis in Rhodococcus: II. Selectivity improvement by genetic and culture optimization. Submitted to Biotechnol. Bioeng.
228. Yanagimachi, K.S., D.E. Stafford, S.K. Rijhwani, B.C. Buckland, A.J. Sinskey, and
G. Stephanopoulos. Metabolic engineering of inandiol synthesis in Rhodococcus:
I. Mutant isolation and characterization in continuous cultures. Submitted to
Biotechnol. Bioeng.
227. Yanagimachi, K.S., D.E. Stafford, A.F. Dexter, A.J. Sinskey, S. Drew and G.
Stephanopoulos. 2001. Application of Radiolabeled Tracers to Biocatalytic Flux
Analysis. Eur. J. Biochem. 268(18):4950-4960.
226. Willis, L.B., P.A. Lessard and A. Sinskey. 2001. Amino Acids. In: Encyclopedia of Genetics. Brenner, S. and Miller, J.H. (eds.), Academic Press: London. pp. 54-
56.
225. Loos, A., C. Glanemann, L. Willis, X. O'Brien, P. Lessard, R. Gerstmeir, S.
Guillouet and A.J. Sinskey. 2001. Development and Validation of
Corynebacterium DNA Microarrays. Appl. Environ. Microbiol. 67(5):2310-2318.
224. Jia, Y., T.J. Kappock, T. Frick, A.J. Sinskey and J. Stubbe. 2000. Lipases provide a new mechanistic model for polyhydroxybutyrate (PHB) synthases: characterization of the functional residues in C. vinosum PHB synthase. J.
Biochemistry 39(14):3927-36.
223. Guillouet, S., P.A. Lessard and A.J. Sinskey. 2000. Investigating Microbial
Metabolic Pathways with NMR: Metabolism of Amino Acids in Corynebacteria.
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In: NMR in Microbiology: Theory and Applications. Barbotin J.N. and Portais,
J.C. (eds.), Horizon Scientific Press: Wymondham, UK. pp. 259-281.
222. Lessard, P.A., X.M. O’Brien, N.A. Ahlgren, S.A. Ribich and A.J. Sinskey. 1999.
Characterization of IS1676 from Rhodococcus erythropolis SQ1. Appl. Microbiol.
Biotechnol. 52:811-819.
221. Guillouet, S., A.A. Rodal, G.-H. An, P.A. Lessard and A.J. Sinskey. 1999.
Expression of the Escherichia coli catabolic threonine dehydratase in
Corynebacterium glutamicum and its effect on isoleucine production. Appl.
Environ. Microbiol. 65(7):3100-3107.
220. An, G.H., K.B. Song and A.J. Sinskey. 1999. Redirection of Carbon Flux to Lysine in a Recombinant of Corynebacterium lactofermentum ATCC 21799 by Limited
Supply of Pantothenate. J. Biosci. Bioengr. 88(2):168-172.
219. Lessard, P.A., S. Guillouet, L.B. Willis and A.J. Sinskey. 1999. Corynebacteria,
Brevibacteria. Encyclopedia of Bioprocess Technology: Fermentation,
Biocatalysis, and Bioseparation. Flickinger, M.C. and Drew, S.W. (eds.), John
Wiley and Sons, Inc.: New York. pp. 729-740.
218. Treadway, S.L., K.S. Yanagimachi, E. Lankenau, P.A. Lessard, G.
Stephanopoulos and A.J. Sinskey. 1999. Isolation and characterization of indene bioconversion genes from Rhodococcus strain I24. Appl. Microbiol. Biotechnol.
51(6):786-793.
217. Goswami, J., AJ Sinskey, H. Steller, G.N. Stephanopoulos and D.I.C. Wang. 1999.
Apoptosis in batch cultures of Chinese hamster ovary cells. Biotechnol. Bioeng.
62(6):632-640.
216. Shaw-Reid, C.A., M.M. McCormick, A.J. Sinskey, G. Stephanopoulos. 1999. Flux through the tetrahydrodipicolinate succinylase pathway is dispensible for Llysine production in Corynebacterium glutamicum. Appl. Microbiol. Biotechnol.
51(3):325-333.
215. Klapa, M.I., S.M. Park, A.J. Sinskey and G. Stephanopoulos. 1999. Metabolite and isotopomer balancing in the analysis of metabolic cycles: I. Theory.
Biotechnol. Bioeng. 62(4):375-391.
214. Park, S.M., M.I. Klapa, A.J. Sinskey and G. Stephanopoulos. 1999. Metabolic and isotopomer balancing in the analysis of metabolic cycles: II. Applications.
Biotechnol. Bioeng. 62(4):392-401.
213. Muh, U., A.J. Sinskey, D.P. Kirby, W.S. Lane and J. Stubbe. 1999. PHA synthase from Chromatium vinosum: cysteine 149 is involved in covalent catalysis.
Biochemistry 38(2):826-37.
34

212. Dauvillee, D., C. Colleoni, E. Shaw, G. Mouille, C. D’Hulst, M. Morell, M.
Samuel, B. Bouchet, D. Gallant, A. Sinskey and S. Ball. 1999. Novel, starch-like polysaccharides are synthesized by an unbound form of granule-bound synthase in glycogen-accumulating mutants of Clamydomanas reinhardtii. Plant
Physiology 119:321-329.
211. Guillouet, S., J.H. Choi, C.K. Rha and A.J. Sinskey. 1999. Effects of yeast extract on the production and the quality of the exopolysaccharide, Zooglan, produced by Zoogloea ramigera 115SLR. Appl. Microbiol. Biotechnol. 51:235-240.
210. Koffas, M.A.G., R. Ramamoorthi, W.A. Pine, A.J. Sinskey and G.
Stephanopoulos. 1998. Sequence of the Corynebacterium glutamicum pyruvate carboxylase gene. Appl. Microbiol. Biotechnol. 50(3):346-352.
209. Chung, J.D., A.J. Sinskey and G. Stephanopoulos. 1998. Growth factor and BCL-
2 mediated survival during the abortive proliferation of a hybridoma cell line.
Biotechnol. Bioeng. 57(2):164-171.
208.
Sim, S.J., K.D. Snell, S.A. Hogan, J. Stubbe, C. Rha and A.J. Sinskey. 1997. PHA synthase activity controls the molecular weight and polydispersity of polyhydroxybutyrate in vivo. Nat. Biotechnol. 15(1):63-67.
207. Park, S. M., A.J. Sinskey and G. Stephanopoulos. 1997. Metabolic and physiological studies of Corynebacterium glutamicum mutants. Biotechnol.
Bioeng. 55(6):864-879.
206. Lee, S.P., O.S. Kwon and A.J. Sinskey. 1996. Localization of genes involved in exopolysaccharide biosynthesis in Zooglea ramigera 115SLR. J. Microbiol.
Biotechnol. 6(5):321-325.
205. Ersoy, O., R. Fleck, A.J. Sinskey and S. Masamune. 1996. N  O acyl transfer reaction catalyzed by antibodies. J. Am. Chem. Soc. 118:13077-13078.
204. Wodzinska, J. K. Snell, A. Rhomderg, A. J. Sinskey, K. Biemann and J. Stubbe.
1996. Polyhydroxybutyrate synthase: evidence for covalent catalysis. J. Am.
Chem. Soc. 118(26):6319-6320.
203. Park, S. M., C.A. Shaw-Reid, A.J. Sinskey and G. Stephanopoulos. 1996.
Elucidation of anaplerotic pathways in Corynebacterium glutamicum via 13C-
NMR spectroscopy and GCMS. Appl Microbiol. Biotechnol. 47(4):430-440.
202. Chen, K., G. Stephanopoulos, A.J. Sinskey and H.F. Lodish. 1995. Regulated secretion of Prolactin by the mouse insulinoma cell line  TC-3. Biotechnology
13(11):1191-1197.
35

201. Colón, G.E., T.T. Nguyen, M.S.M. Jetten, A.J. Sinskey and G. Stephanopoulos.
1995. Production of isoleucine by overexpression of ilvA in a Corynebacterium
lactofermentum threonine producer. Appl. Microbiol. Biotechnol. 43(3):482-488.
200. Jetten, M.S.M. and A.J. Sinskey. 1995. Recent advances in the physiology and genetics of amino acid-producing bacteria. Crit. Rev. Biotechnol. 15(1):73-103.
199.
Zupke, C., A.J. Sinskey and G. Stephanopoulos. 1995. Intracellular flux analysis applied to the effect of dissolved oxygen on hybridomas. Appl. Microbiol.
Biotechnol. 44(1-2):27-36.
198. Colón, G.E., S.M. Jetten, T.T. Nguyen, M. Gubler, M.T. Follettie, A.J. Sinskey and
G. Stephanopoulos. 1995. Effect of inducible thrB expression on amino acid production in Corynebacterium lactofermentum ATCC 21799. Appl. Environ.
Microbiol. 61(1):74-78.
197. Hwang, C., H.F. Lodish, A.J. Sinskey. 1995. Measurement of glutathione redox state in cytosol and secretory pathway of cultured cells. Methods Enzymol.
251:212-221.
196. Shelikoff, M., A.J. Sinskey and G. Stephanopoulos. 1994. The effect of protein synthesis inhibitors on the glycosylation site occupancy of recombinant human prolactin. Cytotechnology 15(1-3):195-208.
195. Suga, H., I.N. Tanimoto, A.J. Sinskey and S. Masamune. 1994. Glycosidase antibodies induced to a half-chair transition-state analog, J. Am. Chem. Soc.
116:11197-11198.
194. Jetten, M.S. and A.J. Sinskey. 1994. Purification and properties of oxaloacetate decarboxylase from Corynebacterium glutamicum. Antonie van Leeuwenhock 00:
1-7.
193. Suga, H., O. Ersoy, S.F. Williams, T.Takeshi, M.N. Margolies, A.J. Sinskey and S.
Masamune. 1994. Catalytic antibodies generated via heterologous immunization. J. Am. Chem. Soc. 116:6025-6026.
192. Jetten, M.S., M.E. Gubler, S.H. Lee and A.J. Sinskey. 1994. Structural and functional analysis of pyruvate kinase from Corynebacterium glutamicum. Appl.
Environ. Microbiol. 60(7):2501-2507.
191. Gubler, M., M. Jetten, S.H. Lee and A.J. Sinskey. 1994. Cloning of the pyruvate kinase gene (pyk) of Corynebacterium glutamicum and site-specific inactivation of
pyk in a lysine-producing Corynebacterium lactofermentum. Appl. Environ.
Microbiol. 60:2494-2500.
190. Gerngross, T.U., K.D. Snell, O.P. Peoples, A.J. Sinskey, E. Csuhai, S. Masamune and J. Stubbe. 1994. Overexpression and purification of the soluble
36

polyhydroxyalkanoate synthase from Alcaligenes eutrophus: Evidence for a required post-translational modification for catalytic activity. Biochemistry
33(31):9311-9320.
189. Kim, S.K., I.S. Kong, K.J. Kwon, C. Rha, A.J. Sinskey and J.Y. Kong. 1994.
Exopolysaccharide produced by Z. ramigera mutants and analysis of structuralchange by solution properties. Biotechnol. Letts. 16(8):789-794.
188. Jetten, M.S.M., M.T. Follettie and A.J. Sinskey. 1995. Effect of different levels of aspartokinase on the lysine production of Corynebacterium lactofermentum, Appl.
Microbiol. Biotechnol. 43:76-82.
187. Jetten, M.S.M., G.A. Pitoc, M.T. Follettie and A.J. Sinskey. 1994. Regulation of phosphoenol pyruvate and oxaloacetate converting enzymes in Corynebacterium
glutamicum. Appl. Microbiol. Biotechnol. 41:47-52.
186. Suga, H. O. Ersoy, T. Takeshi, L. Jung, A.J. Sinskey and S. Masamune. 1994.
Esterolytic antibodies induced to haptens with a 1,2-Aminoalcohol functionality.
J. Am. Chem. Soc. 116:487-494.
185.
Lee, H.-S. and A. J. Sinskey. 1994. Molecular characterization of aceB, a gene encoding malate synthase in Corynebacterium glutamicum. J. Microbiol.
Biotechnol. 4:256-263.
184. Jetten, M.S.M., M.T. Follettie and A.J. Sinskey. 1994. Metabolic engineering of
Corynebacterium glutamicum. In: Recombinant DNA Technology II, Bajpai and
Prokop (eds.), Proc. N.Y. Acad. Sci. 721:12-29.
183. Gubler, M., S.M. Park, M. Jetten, G. Stephanopoulos and A.J. Sinskey. 1993.
Effects of phosphoenol pyruvate carboxylase deficiency on metabolism and lysine production in Corynebacterium glutamicum. Appl. Microbiol. Biotechnol.
40:857-863.
182. Gerngross, T.U., P. Reilly, A.J. Sinskey, J. Stubbe and O.P. Peoples. 1993.
Immunocytochemical analysis of PHB granules from Alcaligenes eutrophus. J.
Bacteriol. 175(16):5289-5293.
181. Archer, J.A.C. and A.J. Sinskey. 1993. The DNA sequence and minimal replicon of the Corynebacterium glutamicum plasmid pSR1: Evidence of a common ancestry with plasmids from C. diphtheriae. J. Gen. Microbiol. 139:1753-1759.
180. Jetten, M.S.M., M.E. Gubler, G.E. Colon, M.M. McCormick, M.T. Follettie and
A.J. Sinskey. 1993. Molecular organization and regulation of the biosynthetic pathway and aspartate derived amino acids in Corynebacterium glutamicum. In:
Proc. of 5th ASM Conference on Genetics and Molecular Biology of Industrial
Microorganisms. Baltz, R.H., Hegeman, G.D. and Skatrud, P.L. (eds.), ASM,
37

Washington, DC, Industrial Microorganisms: Basic and Applied Molecular
Genetics, pp. 97-104.
179. Stephanopoulos, G. and A.J. Sinskey. 1993. Metabolic engineering - methodologies and future prospects. Trends Biotechnol. 11(9):392-396.
178. Jetten, M.S.M. and A.J. Sinskey. 1993. Characterization of phosphoenol pyruvate carboxykinase from Corynebacterium glutamicum. FEMS Microbiol. Lett.
111:183-188.
177. Follettie, M.T., O.P. Peoples, C. Agoropoulou and A.J. Sinskey. 1993. Gene
Structure and Expression of the Corynebacterium flavum N13 ask-asd Operon. J.
Bacteriol. 175:4096-4103.
176. Hwang, C., A.J. Sinskey and H.F. Lodish. 1992. The oxidized potential in the endoplasmic reticulum: Glutathione as the principal redox buffer. Science
257:1496-1502.
175. Bor, Y.-C., C. Moraes, S.-P. Lee, W.L. Crosby, A.J. Sinskey and C.A. Batt. 1992.
Cloning and nucleotide sequence of the Lactobacillus brevis xylose isomerase.
Gene 114:127-131.
174. Williams, S.F., M.A. Palmer, O.P. Peoples, C.T. Walsh, A.J. Sinskey and S.
Masamune. 1992. Biosynthetic thiolase from Zoogloea ramigera. Mutagenesis of the putative active site base Cys-378 to Ser-378 changes the partitioning of the acetyl-S-enzyme intermediate. J. Biol. Chem. 267(23):16041-16043.
173. Jain, J., V.E. Valge-Archer, A.J. Sinskey and A. Rao. 1992. The AP-1 site at -150 bp, but not the NF B site, is likely to represent the major target to protein kinase
C in the interleukin-2 promoter. J. Exp. Med. 175:853-862.
172. Liebl, W., A.J. Sinskey and K.-H. Schleifer. 1992. Expression, secretion and processing of staphylococcal nuclease by Corynebacterium glutamicum. J.
Bacteriol. 174:1854-1861.
171. Follettie, M.T., O.P. Peoples, J.A.C. Archer and A.J. Sinskey. 1991. Metabolic engineering of Corynebacteria. Proceedings of the 6th International Symposium on Genetics of Industrial Microorganisms. Vol. 1. pp. 315-325.
170. Palmer, M.A.J., E. Differding, R. Gamboni, S.F. Williams, O.P. Peoples, C.T.
Walsh, A.J. Sinskey and S. Masamune. 1991. Biosynthetic thiolase from Zoogloea
ramigera. Evidence for a mechanism involving Cys-378 as the active site base. J.
Biol. Chem. 266(13):8369-8375.
169. Hwang, C. and A.J. Sinskey. 1991. The role of oxidation-reduction potential in monitoring growth of cultured mammalian cells. In: Production of Biologicals
38

from Animal Cells in Culture, Spier, R.E., Griffiths, J.B. and Meignier, B. (eds.),
ESACT, Butterworth-Heinemann, pp. 548-568.
168. Archer, J.A.C., D.E. Solow-Cordero and A.J. Sinskey. 1991. A C-terminal deletion in Corynebacterium glutamicum homoserine dehydrogenase abolishes allosteric inhibition by L-threonine. Gene 107:53-59.
167. Valge-Archer, V.E., J. de Villiers, A.J. Sinskey and A. Rao. 1990. Transformation of T lymphocytes by the v-fos oncogene. J. Immunol. 145:4355-4364.
166. Follettie, M.T. and A.J. Sinskey. 1990. Corynebacterium glutamicum - A model for the use of recombinant DNA technology in food grade microorganisms. In:
Biotechnology and Food Safety. Bills, D.D. and Kung, S.-D, (eds.), Butterworth-
Heinemann: Boston, pp. 277-290.
165. Peoples, O.P. and A.J. Sinskey. 1990. PHB: A Model System for Biopolymer
Engineering II. In: Novel Biodegradable Microbial Polymers. Dawes, E.A. (ed.),
Kluwer Academic Publishers: London, vol. 186, pp. 191-202.
164. Ozaki, A., E.J. Toone, C.H. von der Osten, A.J. Sinskey and G.M. Whitesides.
1990. Overproduction and substrate specificity of a bacterial fuculose-1phosphate aldolase: A new enzymatic catalyst for stereocontrolled aldol condensation. J. Am. Chem. Soc. 112:4970-4971.
163. Liebl, W., K.H. Schleifer and A.J. Sinskey. 1990. Secretion of heterologous proteins by Corynebacterium glutamicum. Genetic Transformation and Expression pp. 553-559.
162. Marcel, T., J.A.C. Archer, D. Mengin-Lecreulx and A.J. Sinskey. 1990.
Nucleotide sequence and organization of the upstream region of the
Corynebacterium glutamicum lysA gene. Molec. Microbiol. 4(11):1819-1830.
161. Adema, E., D. Shnek, F. Cahn and A.J. Sinskey. 1990. Use of porous microcarriers in agitated cultures. BioPharm. 3(7):20-24.
160. Han, K.-S., J.A.C. Archer and A.J. Sinskey. 1990. The molecular structure of the
Corynebacterium glutamicum threonine synthase gene. Molec. Microbiol. 4:1693-
1702.
159. von der Osten, C.H., C. Gioannetti, C. Barbas, R.L. Pederson, Yi-F. Wang, C.-H.
Wong, A. Ozaki, E. Toone, G.M. Whitesides and A.J. Sinskey. 1990. Molecular cloning of aldolases for synthetic applications. Ann. N.Y. Acad. Sci. (Proc. 10th
Enzyme Engineering Conference), Vol. 613, pp. 771-775.
158. Jamas, S., Y.-C.J. Chen, C.H. von der Osten, A.J. Sinskey and C.K. Rha. 1990.
Spectral analysis of glucan produced by wild-type and mutant Saccharomyces
cerevisiae. J. Carbohydr. Polym. 13:207-219.
39

157.
Toone, E.J., Kobori, Y., D.C. Myles, A. Ozaki, W. Schmid, C. von der Osten, A.J.
Sinskey and G.M. Whitesides. 1990. Enzymes as catalysts in carbohydrate synthesis. In: Chemical Aspects of Enzyme Biotechnology. Baldwin, T.O. (ed.),
Plenum Press: New York, pp. 179-195.
156. Sambanis, A., G. Stephanopoulos, A.J. Sinskey and H.F. Lodish. 1990. Use of regulated secretion in protein production from animal cells: An evaluation with the AtT-20 model cell line. Biotechnol. Bioeng. 35:771-780.
155. Eikmanns, B.J., M.T. Follettie, M.U. Griot and A.J. Sinskey. 1989. The phosphoenolpyruvate carboxylase gene of Corynebacterium glutamicum:
Molecular cloning, nucleotide sequence, and expression. Mol. Gen. Genet.
218:330-339.
154. Morimoto, S., M. Matsuo, K. Azuma and A.J. Sinskey. 1989. Purification and properties of D-xylulose reductase from Pachysolen tannophilus. J. Ferment.
Technol. 64(3):219-225.
153. von der Osten, C.H., C.F. Barbas, C.-H. Wong and A.J. Sinskey. 1989. Molecular cloning, nucleotide sequence and fine structural analysis of the Corynebacterium
glutamicum fda gene: Structural comparison of C. glutamicum fructose-1,6biphosphate aldolase to Class I and Class II aldolases. Molec. Microbiol. 3:1625-
1638.
152. Archer, J.A.C., M.T. Follettie and A.J. Sinskey. 1989. Biology of Corynebacterium
glutamicum: A Molecular Approach. In: Genetics and Molecular Biology of
Industrial Microorganisms. Report on Proceedings. Fourth Conference on
Genetics of Industrial Microorganisms, Hershberger, C.L., Queener, S.W. and
Hegeman, G., (eds.), American Society for Microbiology, pp. 27-34.
151. Walsh, C., W.H. Chen, E. Differding, S. Masamune, O. Peoples, O. Ploux, A.J.
Sinskey and S. Thompson. 1989. Enzymes in the biosynthesis of polyesters.
Proc. Robert A. Walsh Found. Conf. Chem. Res. 31:184-203.
150. Masamune, S., C.T. Walsh, A.J. Sinskey and O.P. Peoples. 1989. Poly(R)-3hydroxybutyrate (PHB) biosynthesis: Mechanistic studies on the biological
Claisen condensation catalyzed by ß-ketoacyl thiolase. Pure and Appl. Chem.
61:303-312.
149. Thompson, S., F. Mayer, O.P. Peoples, S. Masamune, A.J. Sinskey and C.T.
Walsh. 1989. Mechanistic studies on  -ketoacyl thiolase from Z. ramigera:
Identification of the active-site nucleophile as Cys89, its mutation to Ser89, and kinetic and thermodynamic characterization of wild type and mutant enzymes.
Biochemistry 28:5735-5742.
40

148. von der Osten, C., C. Gioannetti and A.J. Sinskey. 1989. Design of a defined medium for growth of Corynebacterium glutamicum in which citrate facilitates iron uptake. Biotechnol. Letts. 11:11-16.
147. Peoples, O.P. and A.J. Sinskey. 1989. Poly-(ß)-hydroxybutyrate biosynthesis in
Alcaligenes eutrophus H16: Identification and characterization of the PHB polymerase gene (phbC). J. Biol. Chem. 264:15298-15303.
146. Peoples, O.P. and A.J. Sinskey. 1989. Poly-(ß)-hydroxybutyrate biosynthesis in
Alcaligenes eutrophus H16: Characterization of the genes encoding ß-ketothiolase and acetoacetyl-CoA reductase. J. Biol. Chem. 264(26):15293-15297.
145. Masamune, S., M.A.J. Palmer, R. Gamboni, S. Thompson, J.T. Davis, S.F.
Williams, O.P. Peoples, A.J. Sinskey and C.T. Walsh. 1989. Bio-Claisen condensation catalyzed by thiolase from Zoogloea ramigera. Active site cysteine residues. J. Amer. Chem. Soc. 111:1879-1881.
144. Glacken, M.W., C. Hwang and A.J. Sinskey. 1989. Mathematical descriptions of hybridoma culture kinetics. III. Simulation of fed-batch bioreactors. J.
Biotechnol. 10:39-66.
143. Von der Osten, C.H., A.J. Sinskey, C.F. Barbas, R.L. Pederson, Y.-F. Wang and C.-
H. Wong. 1989. Use of a recombinant bacterial fructose-1,6-diphosphate aldolase in aldol reactions: preparative syntheses of 1-deoxyjirimycin, 1deoxymannojimycin 1,4-dideoxy-1,4-imino-d-arabinitol and fagomine. J. Amer.
Chem. Soc. 111:3924-3927.
142. Valge, V.E., J. Wong, B.M. Datlof, A.J. Sinskey and A. Rao. 1988. Protein kinase
C is required for responses to T cell receptor ligands but not to interleukin 2 in T cells. Cell 55:101-112.
141. Liebl, W. and A.J. Sinskey. 1988. Molecular cloning and nucleotide sequence of a gene involved in the production of extracellular DNase by Corynebacterium
glutamicum. In: Genetics and Biotechnology, Ganesan, A.T. and Hoch, J.A. (eds.),
Academic Press: New York, Vol. 2, pp. 383-390.
140. Peoples, O.P. and A.J. Sinskey. 1988. Fine structural analysis of the Zoogloea
ramigera phbA-phbB locus encoding ß-ketothiolase and acetoacetyl-CoA reductase: Nucleotide sequence of phbB. Molec. Microbiol. 3(3):349-357.
139. Chow, J.J., C.A. Batt and A.J. Sinskey. 1988. Characterization of Lactobacillus
bulgaricus bacteriophage ch2. Appl. Environ. Microbiol. 54(5):1138-1142.
138. Yeh, P., A.M. Sicard and A.J. Sinskey. 1988. General organization of the genes specifically involved in the DAP-lysine pathway of Corynebacterium glutamicum.
Mol. Gen. Genet. 212:105-111.
41

137. Yeh, P., A.M. Sicard and A.J. Sinskey. 1988. Nucleotide sequence of the LysA gene of Corynebacterium glutamicum and possible mechanism for modulation of expression. Mol. Gen. Genet. 212:112-119.
136. Follettie, M.T., H.K. Shin and A.J. Sinskey. 1988. Organization and regulation of the Corynebacterium glutamicum hom-thrB and thrC loci. Molec. Microbiol.
2(1):53-62.
135. Peoples, O.P., W. Liebl, M. Bodis, P.J. Maeng, M.T. Follettie, J.A. Archer and A.J.
Sinskey. 1988. Nucleotide sequence and fine structural analysis of the
Corynebacterium glutamicum hom-thrB operon. Molec. Microbiol. 2(1):63-72.
134. Glacken, M.W., E. Adema and A.J. Sinskey. 1988. Mathematical description of hybridoma culture kinetics for optimization of bioreactors: I. Initial metabolic rates. Biotechnol. Bioeng. 32:491-506.
133. Glacken, M.W., E. Adema and A.J. Sinskey. 1988. Mathematical descriptions of hybridoma culture kinetics: II. The relationship between thiol chemistry and the degradation of serum activity. Biotechnol. Bioeng. 33:440-451.
132. Easson, D.D., Jr., Peoples, O.P. and Sinskey, A.J. 1987. Biopolymer Engineering:
Genetic Control of Exopolysaccharide Biosynthesis. Presented at Symposium on
Modification and Applications of Industrial Polysaccharides. 193rd ACS
National Meeting, Denver, Colorado, April 5-10, 1987.
131. Peoples, O.P. and A.J. Sinskey. 1987. Polyhydroxybutyrate (PHB): A model system for biopolymer engineering. Prog. Biotechnol. 3:51-56.
130. Jamas, S., C.K. Rha and A.J. Sinskey. 1987. Tailoring of Yeast ß-Glucans by
Strain Selection. In: Industrial Polysaccharides: The Impact of Biotechnology and Advanced Methodologies. Stivala, S.S., Crescenzi, V. and Dea, I.C.M. (eds.),
Gordon and Breach: New York, pp. 35-44.
129. Easson, D.D. Jr., A.J. Sinskey and O.P. Peoples. 1987. Isolation of Zoogloea
ramigera I-16-M exopolysaccharide biosynthetic genes and evidence for instability within this region. J. Bacteriol. 169:4518-4524.
128. Liebl, W. and A.J. Sinskey. 1987. Molecular cloning and nucleotide sequence of a gene involved in the production of extracellular DNase by Corynebacterium
glutamicum. Proceedings of the Fourth International Conference on Bacilli, San
Diego, CA. June 21-24, 1987.
127. Morimoto, S., T. Tawaratani, K. Azuma and A.J. Sinskey. 1987. Purification and properties of D-xylulose reductase from Pachysolen tannophilus. J. Ferment. Tech.
65(1):17-21.
42

126. Sinskey, A.J. and C.A. Batt. 1987. Fungi as a Source of Protein. In: Food and
Beverage Mycology, Beuchat, L.R., (ed.), 2nd Edition. Van Nostrand Reinhold:
New York, pp. 435-467.
125. Batt, C.A. and A.J. Sinskey. 1987. Single-Cell Protein. In: Food Biotechnology,
D.E. Knorr (ed.), Marcel Dekker, Inc., pp. 347-362.
124. Davis, J.T., R.N. Moore, B. Imperiali, A. Pratt, K. Kobayashi, S. Masamune, A.J.
Sinskey and C.T. Walsh. 1987. Biosynthetic thiolase from Zoogloea ramigera. 1.
Preliminary characterization and analysis of proton transfer reaction. J. Biol.
Chem. 262(1):82-89.
123. Davis, J.T., J.-H. Chen, S. Masamune, A.J. Sinskey and C.T. Walsh. 1987.
Biosynthetic thiolase from Zoogloea ramigera. 2. Inactivation with haloacetyl CoA analogs. J. Biol. Chem. 262(1):90-96.
122. Peoples, O.P., S. Masmune, C.T. Walsh and A.J. Sinskey. 1987. Biosynthetic
Thiolase from Zoogloea ramigera. 3. Isolation and Characterization of the
Structural Gene. J. Biol. Chem. 262(1):97-102.
121. Adema, E. and A.J. Sinskey. 1987. Analysis of Intra vs. Extra Capillary Growth in a Hollow-Fiber Reactor. Biotech. Prog. 3:74-79.
120. Follettie, M.T., P. Yeh, H.K. Shin, O.P. Peoples, K.S. Han and A.J. Sinskey. 1986.
Development of recombinant DNA technology for Corynebacterium glutamicum:
Isolation and characterization of amino acid biosynthetic genes. In: Genetics of
Industrial Microorganisms. Proceedings of the Fifth International Symposium on the Genetics of Industrial Microorganisms. Alacevic, M., Hranueli, D. and
Toman, Z. (eds.), pp. 239-247.
119. Follettie, M.T. and A.J. Sinskey. 1986. Recombinant DNA technology for
Corynebacterium glutamicum. Food Technol. 40:88-94.
118. Follettie, M.T. and A.J. Sinskey. 1986. Molecular cloning and nucleotide sequence of the Corynebacterium glutamicum pheA gene. J. Bacteriol. 167(2):695-
702.
117. Morimoto, S., M. Matsuo, K. Azuma and A.J. Sinskey. 1986. Purification and properties of D-xylulose reductase from Pachysolen tannophilus. J. Ferment. Tech.
64(3):219-225.
116. Sinskey, A.J. 1986. Biotecnologia. In: Los Paises Industrializados Ante las
Nuevas Tecnologias. II. Experiencias tecnologicas e impactos economicos y sociales. Barbera, J., Gamella, M., Ros F. and Valle, R. (eds.), pp. 49-59.
115. Glacken, M.W., R.J. Fleischaker and A.J. Sinskey. 1986. Reduction of waste product excretion via nutrient control: Possible strategies for maximized product
43

and cell lysis on serum in cultures of mammalian cells. Biotechnol. Bioeng.
28:1376-1389.
114. Jamas, S., C.K. Rha and A.J. Sinskey. 1986. Morphology of yeast cell wall as affected by genetic manipulation of ß(1T6) glycosidic linkage. Biotechnol.
Bioeng. 28:769-784.
113. Sinskey, A.J., D.D. Easson, Jr., S. Jamas and C. Rha. 1986. Biopolymers and
Modified Polysaccharides. In: Biotechnology in Food Processing ,S.K. Harlander and T.P. Labuza (eds.), Noyes Publication, Park Ridge, New Jersey, pp. 73-114.
112. Easson, D.D., Jr., O.P. Peoples, C.K. Rha and A.J. Sinskey. 1986. Engineering of
Biopolymer Flocculants: A Recombinant DNA Approach. In: Symposium on
Flocculation in Biotechnology and Separation Systems , Attia Y.A. (ed.), Elsevier,
Amsterdam, pp. 369-381.
111. Knorr, D. and A.J. Sinskey. 1985. Biotechnology in food production and processing. Science. 229(4719):1224-1229.
110. Batt, C., M. Follettie, H. Shin, P. Yeh and A.J. Sinskey. 1985. Genetic engineering of coryneform bacteria. Trends Biotechnol. 3:305-310.
109. Yoshihama, M., K. Higashio, E.A. Rao, M. Akedo, W.G. Shanabruch, M.T.
Follettie, G.C. Walker and A.J. Sinskey. 1985. A cloning vector system for
Corynebacterium glutamicum. J. Bacteriol. 162:592-597.
108. Batt, C.A., W.S. Shanabruch and A.J. Sinskey. 1985. Expression of pAMa1 tetracycline resistance gene in Corynebacterium glutamicum. Segregation of antibiotic resistance due to intermolecular recombination. Biotech. Letts.
7(10):717-722.
107. Batt, C.A., M.C. Claps, M.S. Bodis, S. Jamas and A.J. Sinskey. 1985. Analysis of xylose operon regulation by Mud-lac fusion: Trans effect of plasmid coded xylose operon. Canadian J. Microbiol. 31(10):930-933.
106. Batt, C.A., S. Carvallo, D.D. Easson and A.J. Sinskey. 1985. Evidence for a xylose metabolic pathway in Saccharomyces cerevisiae. Biotechnol. Bioeng. 28:549-553.
105. Sinskey, A.J. 1984. An Overview of Biotechnology: Current and Future Status. In:
Biotechnology in the Americas: Prospects for Developing Countries. Sawyer,
W.D. (ed.), Proceeding of a Symposium held in San Jose, Costa Rica. May 3, 1983. pp. 9-16.
104. Batt, C.A. and A.J. Sinskey. 1984. Current Status of genetic engineering of
Lactobacillus. Presented at the Symposium on the Importance of Lactic Acid
Fermentation on the Food Industry. November 26-29, 1984, Mexico.
44

103. Pellon, J.R. and A.J. Sinskey. 1984. Heat-Induced Damage to the Bacterial
Chromosome and its Repair. In: The Revival of Injured Microbes. Andrew,
M.H.E. and Russell, A.D. (eds.), Academic Press, pp. 105-122.
102. Colwell, R.R., E.R. Pariser and A.J. Sinskey (eds.). 1984. Biotechnology in the
Marine Sciences. Proceeding of the First Annual MIT Sea Grant Lecture and
Seminar. John Wiley and Sons, New York.
101. Glacken, M.W., R.J. Fleischaker and A.J. Sinskey. 1984. Large-scale production of mammalian cells and their products: Engineering principles and barriers to scale-up. Anal. N.Y. Acad. Sci. 413:355-372.
100. Batt, C.A. and A.J. Sinskey. 1984. Use of Biotechnology in the Production of SCP.
Food Technol. 108-111.
99. Sinskey, A.J. 1983. Organic Chemicals From Biomass: An Overview. In: Organic
Chemicals from Biomass, Ed. Wise, D.L., California, Benjamin/Cummings
Publishing Co., pp. 1-66.
98. Pellon, J.R. and A.J. Sinskey. 1983. Genetic Engineering for Food and Additives,
In: Food Microbiology: Advances and Prospects. Roberts, T.A. and Skinner, F.A.
(eds.), Academic Press: New York, pp. 287-299.
97. Glacken, M.W., R.J. Fleischaker and A.J. Sinskey. 1983. Mammalian cell culture:
Engineering principles and scale-up. Trends Biotechnol. 1:102-109.
96. Pellon, J.R. and A.J. Sinskey. 1983. A note on the repair of Escherichia coli nucleoid structure after heat shock. J. Appl. Bacteriol. 54:437-439.
95. Akedo, M., C.L. Cooney and A.J. Sinskey. 1983. Direct Evidence for Lactate-
Acrylate Interconversion in Clostridium propionicum. Bio/Technology 1:791-794.
94. Pellon, J.R. and A.J. Sinskey. 1983. Genetic Engineering for Food and Additives.
In: Food Microbiology: Advances and Prospects. Skinner, F.A. and Roberts, T.A.
(eds.), Academic Press, pp. 287-300.
93. Awerbuch, T.E. and A.J. Sinskey. 1983. The Effect of Different Genetic
Properties of Salmonella typhimurium on the Determination of Stabilities and
Mutagenic Concentrations of Chemical Carcinogens Using the Diffusion
Bioassay. Mutation Res. 113:13-19.
92. Pellon, J.R., A.J. Sinskey, S.M. Hecht and R.F. Gomez. 1983. Kinetics of
Bleomycin A2 Damage in vivo to the Folded Chromosome of Escherichia coli.
Chem. Biol. Interactions 43:245-251.
91. Schaffeld, G., A.J. Sinskey and C. Rha. 1982. Release of Single-Cell Protein by
Induced Cell Lysis. J. Food Sci. 47:2072-2073.
45

90. Pellon, J.R., R.F. Gomez and A.J. Sinskey. 1982. Association of the Escherichia coli
Nucleoid with Protein Synthesized During Thermal Treatments. In: Heat Shock:
From Bacteria to Man. Schlesinger, M.J., Ashburner, M., Tissieres, A. (eds.), Cold
Spring Harbor Laboratories: New York, pp. 121-125.
89. Giard, D., R. Fleischaker and A.J. Sinskey. 1982. Kinetics of human beta interferon production under different temperature conditions. J. Interferon Res.,
Vol. 2., No. 4, pp. 471-477.
88. Ibe, S.N., A.J. Sinskey and D. Botstein. 1982. Genetic Mapping of Mutations of a
Highly Radiation-Resistant Mutant of Salmonella typhimurium LT2. J. Bact.
152:260-268.
87. Sinskey, A.J. 1981. Chapter 5: Mode of Action and Effective Application. In:
Developments in Food Preservatives - 1. Tilbury, R.H. (ed.), Applied Science
Publishers, Barking: Essex, England, pp. 111-136.
86. Fleischaker, R.J. and A.J. Sinskey. 1981. Oxygen demand and supply in cell culture. Eur. J. Appl. Microbiol. Biotechnol. 12:193-197.
85. Sinskey, A.J., M. Akedo and C.L. Cooney. 1981. Acrylate Fermentations. In:
Trends in the Biology of Fermentations for Fuels and Chemicals. Hollaender, A.
(ed.), Plenum: New York, pp. 473-492.
84. Giard, D.J., R.J. Fleischaker, A.J. Sinskey and D.I.C. Wang. 1981. Large-Scale
Production of Human Fibroblast Interferon. In: Developments in Industrial
Microbiology. Underkofler L.A. and Wulf, M.I. (eds.), Vol. 22, Proc. 37th
General Meeting of the Society for Industrial Microbiology, Flagstaff, Arizona,
August 9-15, 1980. Arlington, VA., pp. 299-309.
83. Yorifuji, T. and A.J. Sinskey. 1980. n-Alkane Oxidation Activity in
Saccharomycopsis lipolytica NRR1 Y 1094. In: Proceedings of the US/USSR Joint
Working Group on Scientific and Technical Cooperation on the Production of
Substances by Microbiological Means, "Fundamentals of Microbial Processes," held October 29-31, 1979, at M.I.T., Cambridge, MA.
82. Fleischaker, R.J., J.C. Weaver and A.J. Sinskey. 1980. Instrumentation for
Process Control in Cell Culture. Adv. Appl. Microbiology 27:137-167.
81. Sinskey, A.J. and R.F. Gomez. 1980. Use of Prokaryotic and Eukaryotic Culture
Systems for Examining Biological Activity of Food Constituents. In: Food and
Health: Science and Technology. Birch G.G and Parker, K.J. (eds.), Applied
Science Publishers: London, pp. 251-286.
80. Akedo, M., C.L. Cooney and A.J. Sinskey. 1980. Bioconversion of Propionate to
Acrylate by Clostridium propionicum. Vol. II. Fuels, Chemicals and Waste
46

Treatment. Moo-Young, M. (ed.), Pergamon Press, Proceedings of the 6th
International Synposium, London, Canada, July 1980, pp. 91-96.
79. Miyasaka, Y., C. Rha and A.J. Sinskey. 1980. Application of Temperature-
Sensitive Mutants for Single-Cell Protein Production. Biotechnol. Bioeng.
22(10):2065-2079.
78. Fleischaker, R.J., D.J. Giard, J. Weaver and A.J. Sinskey. 1980. Progress with
Computer-Coupled Mammalian Cell Culture Investigations. In: Advances in
Biotechnology, Vol. I., Scientific Eng. Principles. Moo-Young, M. (ed.),
Pergamon Press, Proceedings of the 6th International Symposium, London,
Canada, July 1980, pp. 425-430.
77. Dalal, R.K., M. Akedo, C.L. Cooney and A.J. Sinskey. 1980. A microbial route for acrylic acid production. Biosources Digest 2(2):89-97.
76. Miyasaka, Y., A.J. Sinskey, J. DeAngelo and C. Rha. 1980. Characterization of a morphological mutant of Saccharomyces cerevisiae for single-cell protein production. J. Food Sci. 45(3):558-563.
75. Sinskey, A.J., R.J. Fleischaker, M.A. Tyo, D.J. Giard and D.I.C. Wang. 1980.
Production of cell derived products: Virus and interferon. Ann. New York Acad.
Sciences 369:47-59.
74. Trump, J.G., E.W. Merrill, A.J. Sinskey, K.A. Wright, T.G. Metcalf and D.N. Shah.
1980. Destruction of Pathogenic Microorganisms and Toxic Chemicals by
Electron Treatment. In: Proceedings of the Eighth National Conference and
Exhibition on Municipal Sludge Management, Miami Beach, Florida, March 22-
23, 1979.
73. Sinskey, A.J. 1979. Preservatives Added to Foods. In: Nutritional and Safety
Aspects of Food Processing. Tannenbaum S.R. (ed.), Marcel Dekker Publisher:
New York, pp. 369-398.
72. Awerbuch, T.E. and A.J. Sinskey. 1979. Quantitative determination of halflifetimes and mutagenic concentrations of chemical carcinogens using a diffusion bioassay. Mut. Res. 74:125-143.
71. Sasajima, K.-I. and A.J. Sinskey. 1979. Oxidation of L-glucose by a Pseudomonad.
Biochim. Biophys. Acta 571:120-126.
70. Lee, C.-H., T.J. Montville and A.J. Sinskey. 1979. Comparison of the efficacy of steam sterilization indicators. Appl. Environ. Microbiol. 37:1113-1117.
69. Awerbuch, T., T. Samson and A.J. Sinskey. 1979. A quantitative model of diffusion bioassays. J. Theoret. Biol. 79:333-340.
47

68. Ulmer, K.M., R.F. Gomez and A.J. Sinskey. 1979. Ionizing radiation damage to the folded chromosome of Escherichia coli k-12. II. repair of double-strand breaks in DNA. J. Bacteriol. 138:486-491.
67. Ulmer, K.M., R.F. Gomez and A.J. Sinskey. 1979. Ionizing radiation damage to the folded chromosome of Escherichia coli K-12. I. Sedimentation properties of irradiated nucleoids and chromosomal DNA. J. Bacteriol. 138:475-484.
66. Boudrant, J., J. DeAngelo, A.J. Sinskey and S.R. Tannenbaum. 1979. Genetic manipulation of single-cell protein. Process characteristics of cell lysis mutants of Saccharomyces cerevisiae. Biotechnol. Bioeng. 21:659-670.
65. Sinskey, A.J. 1978. Enteropathogenic Escherichia coli: Epidemiology,
Significance and Genetics of Toxicology, Republic of China/USA Food Safety
Workshop, Taiwan, September 12-15, 1978, Proceedings, pp. 42-82.
64. Sinskey, A.J. 1978. Fungi as a Source of Protein. In: Food and Beverage
Mycology. Beuchat, L.R. (ed.), Avi Publishing Co.: Westport, CT., Chapter 12, pp. 334-367.
63. Montville, T.J., C.L. Cooney and A.J. Sinskey. 1978. Streptococcus mutans dextransucrase: A review. Advances Appl. Microbiol. 24:55-84.
62. Sinskey, A.J., J. Boudrant, C. Lee, J. DeAngelo, Y. Miyasaka, C. Rha and S.R.
Tannenbaum. 1978. Applications of Temperature-Sensitive Mutants for Single-
Cell Protein Production. Proceedings of US/USSR Conference on Mechanisms and Kinetics of Uptake and Utilization of Substrates in Processes for the
Production of Single Cell Protein, Moscow-Pushchino, June 4-11, 1977, PB-283-
330-T, pp. 362-383. (US/USSR Joint Group on the Production of Substances by
Microbiological Means.)
61. Sinskey, A.J. 1977. High energy electron irradiation of wastewater liquid residuals. Process Biochemistry 12(5):11-14, 32.
60. Silverman, G.J. and A.J. Sinskey. 1977. Sterilization by Ionizing Radiation. In:
Disinfection, Sterilization and Preservation. Block, S.S. (ed.), 2nd edition, Lea and Febiger: Philadelphia, PA., pp. 542-561.
59. Akedo, M., A.J. Sinskey and R. Gomez. 1977. Antimicrobial action of aliphatic diols and their esters. J. Food Sci. 42:699-701, 706.
58. Zapatka, F.A., G.W. Varney and A.J. Sinskey. 1977. Reversal by casein of the bactericidal effect of cocoa powder by Salmonellae. J. Appl. Bacteriol. 42:21-27.
57. Montville, T.J., C.L. Cooney and A.J. Sinskey. 1977. Measurement and synthesis of insoluble and soluble dextran by Streptococcus mutans. J. Dental Res. 56(8):983-
989.
48

56. Sinskey, A.J., D. Shah and T.J. Metcalf. 1977. Biological Effects of Irradiation with High Energy Electrons. In: Proceedings of the Third National Conference on Sludge Management Disposal and Utilization, Miami Beach, Florida,
December 14-16, 1976. Information Transfer, Inc., Rockville, MD., pp. 160-163.
55. Trump, J.G., K.A. Wright, J.L. Danforth, E.W. Merrill, A.J. Sinskey, T.G. Metcalf,
R. Coomeau, D.N. Shah, B. deBree and R. Emanuelson. 1977. Experience at Deer
Island with Electron Disinfection of Sludge at High Flow Rates. In: Proceedings
Second Internatl. Conference of ESNA Working Group on Waste Irradiation,
Uppsala, Sweden, Aug. 31-Sept. 2, 1977, pp. 73-89.
54. Montville, T.J., C.L. Cooney, A.J. Sinskey. 1977. Distribution of Dextransucrase in Streptococcus mutans and Observations on the Effect of Soluble Dextran on
Dextransucrase Activities. Infect. Immun. 18(3):629-635.
53. Zapataka, F.A., G.W. Varney, A.J. Sinskey. 1977. Distribution of the Bacterial
Effect of Cocoa Powder on Salmonellae by Casein. J. Appl. Bacteriol. 42(1):21-25.
52. Sinskey, A.J. 1976. New Developments in Intermediate Moisture Foods:
Humectants. In: Intermediate Moisture Foods, ed. R. Davies, G.G. Birch and
K.R. Parker. Applied Science Publishers, London, Paper 18, pp. 260-277.
51. Cooney, C.L., J. Leung and A.J. Sinskey. 1976. Growth and Physiology of
Streptococcus mutans During Transients in Continuous Culture. In: Microbial
Aspects of Dental Caries. Stiles, H.M., Loesche, W.J. and O'Brien, T.C. (eds.),
Spec. Suppl. Microbiol. Absts. - Bacteriol., Vol. 3, Information Retrieval, Inc.:
Arlington, VA., pp. 799-807.
50. Ordal, Z.J., J.J. Iandola, B. Ray and A.J. Sinskey. 1976. Detection and
Enumeration of Injured Microorganisms. In: Compendium of Methods for the
Microbiological Examination of Foods. Speck, M.L. (ed.), American Public
Health Association: Washington, D.C., pp. 163-169.
49. White, G.E., C.L. Cooney, A.J. Sinskey and S.A. Miller. 1976. Continuous culture studies on the growth and physiology of Streptococcus mutans. J. Dental Res.
55:239-244.
48. Gomez, R.F., K.D. Blais, A. Herrero and A.J. Sinskey. 1976. Effects of some inhibitors of protein, RNA and DNA synthesis on heat injured Salmonella
typhimurium. J. Gen. Microbiol. 97:19-27.
47. Baldwin, J.E., S.E. Branz, R.F. Gomez, P.L. Draft, A.J. Sinskey and S.R.
Tannenbaum. 1976. Chemical activation of nitrosamines into mutagenic agents.
Tetrahedron Letters, 5:333-336.
49

46. Lemke, H.S. and A.J. Sinskey. 1975. Viruses and ionizing radiation in respect to waste water treatment. Proc. Internat. Atomic Energy Agency Sm 194/203. pp.
99-120.
45. Sinskey, A.J. and S.R. Tannenbaum. 1975. Removal of Nucleic Acids in SCP. In:
Single-Cell Protein II. Tannenbaum, S.R. and Wang, D.I.C. (eds.), M.I.T. Press:
Cambridge, MA, pp. 158-179.
44. Takano, M., A.J. Sinskey and D. Baraldi. 1975. DNA Damage in Salmonella
typhimurium LT-2 by a Combination of Freezing and Nutrition. I.I.F.-I.I.R.,
Commission C1, Sappror 1973-1975, pp. 61-70.
43. Trump, J.G., K.A. Wright, A.J. Sinskey, E.W. Merrill and D.N. Shah. 1975.
Feasibility of High-Energy Electron Irradiation of Municipal Sludge. In: Water -
1975. Bennett, G.F. (ed.), American Institute of Chemical Engineers Symposium
Series, Vol. 71, 367-374.
42. Imada, A., J.W. Hunt, H. VandeSande, A.J. Sinskey and S.R. Tannenbaum. 1975.
Purification and properties of an intracellular ribonuclease from Candida
lipolytica. Biochim Biophys. Acta 395:490-500.
41. Trump, J.G., K.A. Wright, E.W. Merrill, A.J. Sinskey, D. Shah and S. Somer. 1975.
Prospects for high energy electron irradiation of waste-water liquid residuals.
Proc. Internat. Atomic Energy Agency SM 194/503.
40. Sinskey, A.J., D. Shah, K.A. Wright, B.W. Merrill, S. Sommer and J.G. Trump.
1975. Biological effects of high energy electron irradiation of municipal sludge.
Proc. Internat. Atomic Energy Agency SM194/302, pp. 139-149.
39. Gomez, R.F. and A.J. Sinskey. 1974. Effect of aeration on minimal medium recovery of heated Salmonella typhimurium LT-2. J. Bacteriol. 122(1):106-109.
38. Gomez, R. and A.J. Sinskey. 1974. Deoxyribonucleic acid breaks in rifampin treated Salmonella typhimurium LT-2 after exposure to nutritionally complex media. Nature 247:211-212.
37. Kimble, C.E., P.A. Gorczyca and A.J. Sinskey. 1974. Repair of lesions induced in human liver cell DNA by N-nitroso compounds as measured by the bromodeoxyruidine phtolysis methods. Mut. Res. 24:35-39.
36. Gomez, R.R., M. Johnston and A.J. Sinskey. 1974. Characteristics of freeze-dried cells. Cryobiology 10(5):368-374.
35. White, G.E., C.L. Cooney, A.J. Sinskey and S.A. Miller. 1974. A defined continuous culture medium for Streptococcus mutans. J. Dental Res. 63:762.
50

34. Tannenbaum, S.R., A.J. Sinskey, M. Weisman and W. Bishop. 1974. Nitrite in human saliva. Its possible relationship to nitrosamine formation. J. Nat. Cancer
Inst. 53(1):79-84.
33. White, G.E., C.L. Cooney, A.J. Sinskey and S.A. Miller. 1974. An in vitro assay to measure early calcium loss from surface enamel. J. Dental Res. 53(2):481-485.
32. Augenstein, D.C., K. Thrasher, A.J. Sinskey and D.I.C. Wang. 1974.
Optimization in the recovery of a labile intracellular enzyme. Biotechnol.
Bioeng. 160:1433-1447.
31. Gomez, R.F., M. Johnston, A.J. Sinskey. 1974. Activation of Nitrosomorpholine and Nitrosopyrrolidine to Bacterial Mutagens. Mutat Res. 24(1):5-7.
30. Gomez, R.F. and A.J. Sinskey. 1973. Deoxyribonucleic acid breaks in heated
Salmonella typhimurium LT-2 after exposure to nutritionally complex media. J.
Bacteriol. 115(2):522-529.
29. Davies, R. and A.J. Sinskey. 1973. Radiation resistant mutants of Salmonella
typhimurium LT2: Development and characterization. J. Bacteriol. 113(1):133-
144.
28. Davies, R., A.J. Sinskey and D. Botstein. 1973. DNA repair in a highly radiationresistant strain of Salmonella typhimurium. J. Bacteriol. 114(1):357-366.
27. Plitman, M., Y. Park, A.J. Sinskey and R. Gomez. 1973. Viability of
Staphylococcus aureus in intermediate moisture foods. J. Food Sci. 38:1004-1008.
26. Gomez, R., R. Davies, A.J. Sinskey and T.P. Labuza. 1973. Minimal recovery of heated Salmonella typhimurium LT2. J. Gen. Microbiol. 74:267-274.
25. Imada, A., A.J. Sinskey and S.R. Tannenbaum. 1972. A new macromolecular inhibitor of yeast ribonuclease mediated through purine nucleotides. Biochim.
Biophys. Acta 268:674-679.
24. Imada, A., A.J. Sinskey and S.R. Tannenbaum. 1972. Ribonucleic Acid
Degradation in Candida lipolytica. In: Proc. 4th Internat. Fermentation
Symposium, Ferment. Technol. Today, pp. 455-461.
23. Labuza, T.P., K.A., Jones, A.J. Sinskey, R. Gomez, S. Wilson and B. Miller. 1972.
The effect of drying conditions on cell viability and functional properties of single cell protein. J. Food Sci. 37(1):103-107.
22. Sinskey, A.J. 1971. Current status of injury in freeze-dried microorganisms. J.
Milk and Food Technol. 34(11):551-552.
21. Sinskey, A.J., G.C.Y. Chu and D.I.C. Wang. 1971. Concentration and
Purification of Viruses by Ultrafiltration. In: Foods and Bioengineering -
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Fundamental and Industrial Aspects, B. Lawrence and E.J. Koval, eds., Chemical
Engineering Progress Series, A.I.Ch.E., Volume 67, No. 108: pp. 75-80.
20. Augenstein, D.C., A.J. Sinskey and D.I.C. Wang. 1971. Effect of shear on the death of two strains of mammalian tissue cells. Biotechnol. Bioeng. 13:409-418.
19. Labuza, T.P., S. Cassil and A.J. Sinskey. 1971. Stability of intermediate moisture foods. 2. Microbiology. J. Food Sci. 37(1): 154-159.
18. Imada, A., A.J. Sinskey and S.R. Tannenbaum. 1971. Degradation of ribonucleic acid in Candida lipolytica: Extraction of ribonucleic acid degrading enzymes.
Biotechnol. Bioeng. 14:103-122.
17. Castro, A.C., A.J. Sinskey and S.R. Tannenbaum. 1971. Reduction of nucleic acid content in Candida yeast cells by bovine pancreatic ribonuclease a treatment.
Appl. Microbiol. 22(3):422-427.
16. Ohta, S., S. Maul, A.J. Sinskey and S.R. Tannenbaum. 1971. Characterization of heat-shock for reduction of the nucleic acid content of Candida utilis. Appl.
Microbiol. 22(3):415-421.
15. Lewicki, P.P. and A.J. Sinskey. 1970. Precision of RNA separation by polyacrylamide gel electrophoresis. Analyt. Biochem. 33(2):273-278.
14. Sinskey, A.J. and G.J. Silverman. 1970. Characterization of injury to Escherichia
coli ML30 incurred upon freeze-drying. J. Bacteriol. 101(2):429-437.
13.
Wang, D.I.C. and A.J. Sinskey. 1970. Collection of Microbial Cells. In:
Advances in Applied Microbiology. Academic Press: New York, Volume 12, pp.
121-152.
12. Wang, D.I.C., A.J. Sinskey and T. Butterworth. 1970. Enzyme Processing Using
Ultrafiltration Membranes. In: Membrane Science and Technology. Flinn, J.E.
(ed.), Plenum Press: New York, pp. 98-119.
11. Butterworth, T.A., D.I.C. Wang and A.J. Sinskey. 1970. Application of ultrafiltration for enzyme retention during continuous enzymatic reaction.
Biotechnol. Bioeng. 12:615-631.
10. Maul, S., A.J. Sinskey and S.R. Tannenbaum. 1970. A new process for reducing the nucleic acid content of yeast. Nature 228:181.
9. Morhart, R.E., L.J. Mata, A.J. Sinskey and R.S. Harris. 1970. A microbiological and biochemical study of gingival crevice debris obtained from Guatemalan
8.
Mayan Indians. J. Periodontology - Periodontics 41(11):644-649.
Wang, D.I.C., A.J. Sinskey and P. Sonoyama. 1969. Recovery of biological materials through ultrafiltration. Biotechnol. Bioeng. 11:987-1003.
52

7.
6.
4.
3.
5.
2.
1.
Chang, R.S. and A.J. Sinskey. 1968. Observations on the transformation of human amnion cell cultures by the SV40. J. Natl. Cancer Institute 40:505-512.
Silverman, G.J. and A.J. Sinskey. 1968. The Destruction of Microorganisms by
Ionizing Radiation. In: Antiseptic Disinfectants, Fungicides and Chemical and
Physical Sterilization. 3rd edition, Block, S.S. and Lawrence, C.A. (eds.), Lea and
Febiger Publishers: Philadelphia, PA. Chapter 44, pp. 741-761.
Wang, D.I.C., A.J. Sinskey, R. Gerner and R.P. deFillippi. 1968. Effect of centrifugation of the viability of Burkett's lymphoma cells. Biotech. Bioeng.
10:641-649.
Pablo, I.S., A.J. Sinskey and G.J. Silverman. 1967. The selection of microorganisms due to freeze-drying. Food Technology 21(5):64-70.
Sinskey, A.J., G.J. Silverman and S.A. Goldblith. 1967. Influence of platen temperatures and relative humidity during storage on the survival of Salmonella
typhimurium in freeze-dried model systems. Appl. Microbiol. 15(1):22-30.
Sinskey, A.J., I.S. Pablo, G.J. Silverman and L. Ronsivalli. 1967. The effect of packaging on the major microbial flora of irradiated haddock. Nature
213(5074):425-426.
Sinskey, A.J., A.H. McIntosh, I.S. Pablo, G.J. Silverman and S.A. Goldblith. 1964.
Considerations in the recovery of microorganisms from freeze-dried foods.
Health Laboratory Science 1:297-306.
53