Central Michigan University College of Arts & Sciences Course Syllabus CHM 342 Desg. No. I. Survey of Organic Chemistry Title 4(3-3) Credit(Mode) Bulletin Description Elementary course covering the entire field of organic chemistry. Course meets the needs for entrance to some professional schools. No credit toward major or minor. II. Prerequisites CHM 120 and CHM 127, or CHM 132, or equivalent. III. Rationale for Course Level No change IV. Textbooks and Other Materials to be Furnished by the Student 1. 2. 3. V. R. C. Atkins & F. C. Carey, Organic Chemistry, A Brief Course, McGraw-Hill, 1990 Q. R. Petersen, Course Supplement and Laboratory Manual, 5th ed. CMU Press, 1995 Laboratory Safety Glasses Special Requirements of the Course None VI. General Methodology Used in Conducting the Course Lecture and laboratory VII. Course Objectives 1. 2. 3. 4. To extend the knowledge of molecular structure, brought from prerequisite courses, to the compounds of carbon. To emphasize the overarching roles that energy changes play in organic transformations. To become familiar with the nature of the major functional groups. To master the synthetic approaches to the preparation of the major functional groups. 5. 6. 7. To become familiar with the reactions and transformations of the major functional groups. To gain facility with mechanistic models of the primary organic transformations. To become competent in the major laboratory techniques and operations which include: thin layer chromatography, recrystallization, extraction, melting point determination, distillation, codistillation, titration, and centrifugation. These techniques will be used in single-step and multi-step syntheses, studies of five natural products and in an industrial process. After completion of this course the student will be expected to provide a satisfactory performance on an American Chemical Society NationallyStandardized Examination titled, A.C.S Examination Brief Course in Organic Chemistry. Also, the student will have satisfactorily completed all assigned laboratory work. VII. Week 1 2 3 4 5 6 7 8 Course Outline APPROXIMATE COURSE SCHEDULE Approximate Lecture Coverage Laboratory Experiments in Atkins &Carey text Performed on Wednesday Check in and technique demonstrations of Chapter 1. Atomic and Molecular m.p., recrystallization, vacuum filtration, Structure extraction, and use of new equipment. Experiment #2 Chapter 2. Alkanes and Cycloalkanes Thin Layer Chromatography of Analgesics TLC Experiment #3 Chapter 3. Introduction to Organic The Kinds and Reactions of Chemical Reactions Hydrocarbons. Experiment #4 Chapter 4. Alkenes, Alkadienes and Purification of Cholesterol through its Alkynes I Preparations Dibromide. Extraction Experiment #5 Chapter 5. Alkenes, Alkadienes and Preparation of Camphor by the Oxidation Alkynes II Reactions of Isoborneol Oxidation Experiment #6 Chapter 6. Arenes and Aromaticity The Preparation of Acetanilide Recrystallization Experiment #7 Chapter 7. Stereochemistry Sulfanilamide Synthesis Started Multistep Synthesis Experiment #7 Chapter 8. Nucleophilic Substitution Sulfanilamide Synthesis Completed Reactions Multistep Synthesis Hour Exam I II 9 Chapter 10. Alcohols, Ethers and Phenols 10 Chapter 11. Aldehydes and Ketones 11 Chapter 12. Carboxylic Acids 12 Chapter 13. Derivatives of Carboxylic Acids Experiment #8 Preparation of a Designated Ester Distillation Experiment #9 Ascorbic acid (Vitamin C) Analysis Titration Experiment #10 Fats and Oils, Soaps and Detergents Hydrolysis Experiment #11 Some Tests for Fats, Proteins, and Carbohydrates in Milk 13 Chapter 14. Amines No Laboratory this week 14 Chapter 15. Carbohydrates Dyes and Dyeing III Experiment #12 Diazo coupling 15 Chapters 16 & 17. Amino Acids, Proteins and Lipids 16 FINAL EXAM Dow 135 IX Evaluation Weekly quizzes Four hour exams. Comprehensive final exam Lab Reports graded weekly X. Check Out -- All Lab Reports submitted 30% of final grade 30% of final grade 20% of final grade 20% of final grade Bibliography There are usually four or five "Brief Organic" texts in print at any one time. Exemplary are: H. Hart, D. J. Hart & L Craine, Organic Chemistry, A Short Course, 9th ed. Houghton-Mifflin, 1995. P. S. Bailey & C. A. Bailey, Organic Chemistry, A Brief Survey, 5th ed. Prentice Hall, 1995. R. J. Ouellette, Organic Chemistry, A Brief Introduction. Macmillan, 1994. A smaller number of laboratory manuals are in print. Most of the experiments in these manuals require extensive modification to accommodate the order of our lecture coverage, our particular IV laboratory facilities and our particular equipment. For these reasons, a dedicated laboratory manual has been published. A copy is on file in the chemistry department office, Dow 264. Syllabus prepared by: Quentin R. Petersen Name 10/16/95 Date