CONTINUING HOMOEOPATHY MEDICAL EDUCATION SERVICES QUARTERLY HOMOEOPATHIC DIGEST, JUNE 1991 Vol. VIII CURRENT LITERATURE LISTING PART I A list of current homoeopathic literature, subjectwise, is given below. Except for the CCRH Quarterly Bulletin all the others are form the British, American, German, etc. journals not readily accessible to every homoepath. Some of the articles may appear in PART II in later numbers of the Quarterly Homoepathic DIGEST, as abstract/summary/condensation/full, etc. I. PHILOSOPHY: 1. HAHNEMANN and HEGEL or the medicament is the picture of the disease, BUTNER, S (ZKH, 34, 3/1990) 2. On provings and clinical symptoms KELLER, G.V. (AHZ, 235, 3/1990) 3. Is vitalism valid, LEARY, Bernard (BHJ, Vol. 79, 2/1990) 4. Another personal viewpoint, CHAPPELL, Peter (The Homoeopath, 8, 3/1988) 5. CANDEGABE versus EIZAYAGA : Reservation of conflict? CHAPPELL, Peter (The Homoeopath, 8, 4/1988) 6. The CANDEGABE seminar, ROBERTS, Ernest (The Homoeopath, 8, 4/1988) 7. Signs and indications of cure: Some cases, CHAPPELL, Peter (The Homoeopath, 8, 4/1988) 8. Homoeopathic aggravations – a myth or a fact? HARI SINGH; MANCHANDA, R.K; ARORA, Subhash (CCRH Quarterly Bulletin, 12, 3&4/1990) II. MATERIA MEDICA: 1. Ailments of lower abdomen – Nitric acid, GYPSER, K.H, (ZKH, 34, 2/1990) 2. Sensitivity to noise – Asarum europaeum SRINIVASAN, K.S. (ZKH, 34, 2/1990) 3. Verifications and clinical symptoms, (ZKH, 34, 2&3/1990) 4. Constriction of the sphincter – Causticum, EICHLER, R. (ZKH, 34, 3/1990) 5. Cardiospermum halicacabum – proving with potencies D6 and C30 RESPONDEK, U. (ZKH, 34, 3./1990) 6. Folliculinum COOPER, Dorothy (BHJ, 79, 2/1990) 7. Folliculinum : Efficacy in premenstrual syndrome MARTINEZ, Bruno (BHJ, 79, 2/1990) 8. A case of colitis treted with Secale JACK R.A.F. (BHJ, 79, 2/1990) 9. Arsenicum album, ELMORE, Dutt (Resonance, 12, 3/1990) 10. A case in point – the insemination reaction in fruit flies, HERSUC, Paul (Homoepathy Today, 10, 10/1990) 11. An Arnica save HERSCU, Paul (Homoeopathy, 40, 5/1990) 12. Melilotus alba, WILLIAMS, H.N. (The Hahnemannian, June 1990) 13. Arsenicum album WILLIAMS, H.N. (The Hahnemannian, June 1990) III. THERAPEUTICS: 1. Understanding asthma, HOAGLAND, Guy D., (The Hahnemanian, June 1990) 2. Nehrolithiasis depression HEUSTERBERG, K-H, (AHZ, 235, 2/1990) 3. Multiple sclerosis, MULLER, H.V. (AHZ, 235, 3/1990) 4. Progesterone deficiency syndrome – a case, GUISCHARD, A. (AHZ, 235, 3/1990) 5. Dreams, WHITNEY, Kaaren (The Homoeopath, 8, 3/1988) 6. Homoeopathy and counseling: a worthwhile combination, LEE, Felicity (The Homoeopath, 8, 3/1988) 7. Work in progress: The Camelford Water pollution incident, SMITH, Peter (The Homoeopath, 8, 3/1988) 8. Three Cases, Ran-b, Sel., Anac. SWEELVIET, Annete (JAIH, 83, 2/1990) 9. Sewer gas – a 20th Century obstacle to cure ROULEAU, Patricia (JAIH, 83, 2/1990) 10. Sciatica: a case study and differential, KIPNIS, Sheryl R., (Reasonance, 12, 2/1990) 11. Toothache, STEPHENSON, David (Resonance, 12, 3/1990) 12. A case in point, HERSCU, Paul (Homoeopathy Today, 10, 10/1990) 13. NCH/IFH Annual Conference Report, PENNA, Maite (Homoeopathy Today, 10, 10/1990) 14. Post-operative remedies, HOPINS, Barbara (homoeopathy, 40, 5/1990) 15. Evaluation of homoeopathic drugs in Psoriasis HARI SINGH; MANCHANDA R.K., ARORA, Subhash (CCRH Quarterly Bulletin, 12, 3&4/1990) 16. AIDS and Homoeopathy, KHURANA, Anil (CCRH Quarterly Bulletin, 12, 3&4/1990) IV. REPERTORY: 1. Remedy errors in KENT’S Repertory Cocculus and Coccus cacti EPPENICH, H. (ZKH, 34, 2&3/1990) 2. Analysis of rubrics in KENT’s Repertory – “Theorizing” SCHINDLER, M. (ZKH, 34, 2/1990) 3. Confirmation of symptoms in KENT’s Repertory and additions from the Materia Medica, GYPSER, K.H., WALDECKER, A. (ZKH, 34, 3/1990) 4. The story of KENT’s repertory, SAINE, Andre (Resonance, 12, 3/1990) V. RESEARCH 1. Analysing homoeopathic prescribing using the READ classification and information technology. VAN HASELEN, R.A., FISHER, Peter (BHJ, 79, 2/1990) 2. Thinking what we are doing DEMPSEY, Thez; SWAYNE, Jeremy; (BHJ, 79, 2/1990) 3. A study of antibody formation by Baptisia tinctoria in experimental animals, ENGINEER, S.J., VAKIL, A.K; ENGINEER, L.S; (BHJ, 79 2/1990) 4. Scientific support for Homoeopathy, CROOK, Alan (The Homoeopath, 8, 4/1988) 5. Initiatives in homoeopathic research DAVEY, R.W. (Homoeopathy, 40, 5/1990) 6. Drug proving and CCRH, NAGPUL, V.M. (CRH Quarterly Bulletin, 12, 3&4/1990) 7. Clinical verification of hypoglycaemic effect of Cephalandra indica in patients of diabetes mellitus, RASTOGI, D.P. (CCRH Quarterly Bulletin, 12, 3&4/1990) 8. Literary research and Central Council for Research in Homoeopathy NAGPAUL, V.M. (CCRH Quarterly Bulletin, 12, 3&4/1990) VI. PHARMACY: 1. The legacy of HAHNEMANN-the fifty thousand potencies, BARTHEL, P (AHZ, 235, 2/1990) 2. Commentary on the above SCHOPFER, H.J, (AHZ, 235, 2/1990) 3. Mortar & Pestle, BORNEMAN, Jay P. (Resonance 12, 2/1990) 4. An up-date on the regulation of homoeopathic drugs BORNEMAN, Jay P. (Resonance, 12, 3/1990) 5. Homoeopathy and the community pharmacist, AINSWORTH, JBL (Homoeopathy, 40, 5/1990) VII. VETERINARY: 1. Paralysis in a German shepherd, BLAKE Jr., Steve (resonance, 12, 3/1990) 2. Here is a lesson or two LILLARD, Joe (Resonance, 12, 3/1990) VIII. BIOGRAPHY: 1. Robert Thomas COOPER, an introduction to his work, WATSON, Ian (The Homoeopath, 8, 3/1988) 2. John and Elizabeth PATERSON: Reflections and reminiscences; BROWN, Geoffrey (The Homoeopath, 8, 4/1988) IX. HISTORY: 1. Transcription of Hahnemann letters (4), GENNEPER, T. (ZKH, 34, 2/1990) 2. History of the Berlin Homoeopathic Physicians SOHN, FWPH (ZKH, 34, 3/1990) 3. Homoeopathy in 19th century American novels, MICHOT-DIETRICH, Hela (The Homoeopathy, 8, 3/1988) 4. Clinica homoeopathica of Oaxaca: a major homoeopathic teacher center in Mexico, JACOBS, Jennifer (Resonance, 12, 2/1990) 5. The story of KENT’S repertory. SAINE, Andre (Resonance, 12, 3/1990) X. GENERAL: 1. Homoeopathy in the computer age MULLER, H. (ZKH, 34, 2/1990) 2. Survey of the homoepathic periodicals in France BAUR, J. (ZKH, 34, 2/1990) 3. Supervision : a homoeopath’s perspective CASTRO, Mirando (The Homoeopath, 8, 3/1988) 4. The homoeopathic telephonic consultation LAKSKY, Philip, S (JAIH, 83, 2/1990) 5. Homoeopathy and computers MASIELLO, Domenick (JAIH, 83, 2/1990) 6. The IFH professional course – a review of the fourth week LEVATIN, Janet (Resonance, 12, 3/1990) 7. The patient’s choice, JOHNSON, C.D.G. (Homoeopathy, 40, 5/1990) Vol. VIII PART II ARTICLES JUNE 1991 THE ANXIOGENIC EFFECTS OF CAFFEINE, BRUCE, Malcolm S. Postgrad Med. J. (1990) 66, (Suppl.2) Introduction : During psychiatric history taking in the U.K. enquiry into caffeine use remains the exception. Current psychiatric text books used in the U.K. do not give caffeine any prominance, if mentioned at all. The Br. Med. JI. has referred to the association between caffeine and anxiety (Ashton C. H: Caffeine and health, Br. Med. JI. 1987, 295 : 129394). The American Psychiatric – DSM-III-R has specific diagnosis in the organic mental disorders section, Caffeine intoxication – Table I. Table I. Caffeine toxicity as defined in DSM-IIIR. A. Recent consumption of Caffeine, usually in excess of 250mg. B. At least five of the following: 1. Restlessness 2. Nervousness 3. Excitement 4. Insomnia 5. Flushed face 6. Diuresis 7. Gastrointestinal complaints 8. Musle twitching 9. Rambling flow of though and speech 10. Tachycardia or cardiac arrhythmia 11. Periods of inexhaustibility 12. Psychomotor agitation C. Not due to any other mental disorder, such an Anxiety Disorder. Tabel II and III show the similarity between the accepted somatic symptoms of anxiety and caffeine effects. Table II for generalized Anxiety Disorder (GAD) and Table III Criteria for Panic Disorder (PD). Table II. Symptoms present in Generalized Anxiety Disorder 1. Dyspnoea 2. Palpitations or tachycardia 3. Muscle tension 4. Trouble swallowing 5. Dizzines 6. Nausea, or abdominal distress 7. Restlessness 8. Easy fatiguability 9. Hot flushes 10. Sweating 11. Trembling 12. Insomnia 13. 14. 15. 16. 17. 18. Dry mouth Frequent urination Feeling keyed up or on edge Exaggerated startle response Difficulty concentrating Irritability = also listed as symptom of caffeine toxicity. Table III. Symptoms present in Panic Disorder. 1. Dyspnoea 2. Plapitations or tachycardia 3. Chest pain 4. Choking 5. Dizziness 6. Nausea, or abdominal distress 7. Depersonalization or derealisation 8. Paraesthesia 9. Hot flushes 10. Sweating 11. Trembling 12. Fear of dying 13. Going crazy, or loss of control. *= also listed as symptoms of caffeine toxicity. Dietary Sources: Caffeine is consumed mainly in drinks either naturally occurring or as an additive. The actual ‘per drink’ caffeine varies with the method of preparation and the size of the cup. Highest concentrations are found in percolated coffee. Lowest amounts occur in instant coffee. Caffeine levels in tea depend greatly on the length of brewing. Note the number of milligrams of caffeine in a kilogram of tea leaf is greater than that found in an equivalent weight of coffee bean. Hot chocolate drinks average about 5 mg. per cup. There are many over-the-counter preparations used for analgesia and migraine. Pharmacology: Caffeine (1,3,8 – trimethylxanthine) is one of the naturally occurring xanthine derivatives or methyl- xanthines. Caffeine is readily absorbed following all routes of administration, for example, absorption after oral ingestion is 99% complete at 45 minutes. Caffeine is distributed into all body compartments, it crosses the placenta and is excreted in mother’s milk. 15% is plasma protein-bound. It is highly lipid-soluable and higher concentrations are reached in the CSF and brain than in plasma. Liver metabolism is by demethylaton followed by excretion in the urine, about 1% o the caffeine remaining unchanged. the mean plasma elimination may vary, increased in pregnancy and with the use of oral contraceptive pill for more than 6 months, decreased in smokers, possibly in high caffeine users and in patients taking drugs which induce liver enzymes, e.g. refampicin. The biochemical action of caffeine is believed to be mediated by blocking receptors for adenosine. Adenosine dilates blood vessels, particularly in the coronary and cerebral vasculature and inhibits the release of noradrenaline from the autonomic nervous system. Effects of caffeine on normal subjects: Much research contains contradictory evidence about caffeine’s actions. The findings and observations need dividing up into 4 groups. A) acute studies (i.e. on caffeine-native subjects); B) acute on chronic studies (i.e. caffeine challenges in habitual caffeine users); C) toxic effects; D) withdrawal effects. A. Acute Studies: Caffeine produced significant increases in anxiety and nervousness at 30 minutes and a decrease and calmness at 90 minutes. dose related increase was observed. 2 subjects developed unequivocal panic attacks characterized by acute fear of imminent death; hyperventilation and carpopeddal spasm was prominent in one case. B. Acute on chronic studies: Regular users given 500mg show less response. This is due to tolerance. Any caffeine intake, a sudden increase of more than 500mg of caffeine in a day will result in caffeine toxicity. More gradual increases may not do this. Regardign sleep, tolerance does occur, but if omitted, people still report falling asleep sooner and having a better quality of sleep. The one benefit of regular caffeine use seems to be boosting performance that otherwise fails due to boredom or fatigue. Measures used to study caffeine’s relation to many physiological and psychological correlates of anxiety: i) Self rating scales, ii) Electroencephalogram, EEG is the only true measure readily available for psycho-physiological study. In anxiety states alpha activity is reduced and there is a higher proportion of beta activity. Generally, stimulants affect on-going EEG by increasing alpha, iii) Skin conductance. Palmar sweating is believed to be emotionally determined and evidence of increased skin conductance in anxious patients has been repeatedly shown. A rreduction in skin conductance was also found to correlate with clinical improvement. C. Toxic effects: High sudden increases in consumption have been associated with delirium, abdominal cramps, vomiting, high anxiety, hostility and psychosis. All these symptoms clear within 48 hours of abstention from caffeine. Rare fatalities have occurred with oral doses about 6.5 grams in adults. D. Withdrrawal effects: The best-known of the withdrawal effects is headache. withdrawal syndrome has an onset at 12-24hou peak at 20-48 hours and duration of about one week. Headache and fatigue are the most frequent withdrawal symptoms with a wide variety of other signs occurring less often including anxiety, impaired performance, nausea, vomiting and craving. Caffeine and anxiety disorders: Caffeine toxicity may be in-distinguishable clinically from anxiety states other than by history. Caffeine intake enquiry as a routine part of a psychiatric history taking will ensure that this diagnostic error is avoided. Of equal clinical interest is how important is normal caffeine intake as an external factor in the triggering and or maintenance of anxiety states, and does caffeine affect the subsequent severity of the anxiety state. Anxiety disorder patients were significantly more sensitive to caffine and drank less caffeine than the control group. The caffeineassociated symptom check list showed increased sensitivity to caffeine with respect to anxiety, tremors, muscle tension, panic attacks, lightheadedness and diarrhea. There is marked significant correlation between trait anxiety and caffeine consumption in anxiety disorder patients. Using caffeine challenges, two pain disorder patients with agoraphobia were more sensitive to the anxiogenic effects than 7 controls. Case : A 33 year old single female, working as an assistant architech and looking after a 3 year old child. Daily caffeine consumption was 540 mg. in the form of tea only as she found coffee made ‘everything go inside-out’ with the onset of tremor and other panic-like symptoms. She gave a 10year history of anxiety with panic attacks. 10 years ago the initial symptom was palpitations, with later unsteady feelings, depersonalization, paraesthesia, fear of dying and the fear of doing something uncontrolled. Attacks had a rapid onset, lasted 5 to 30 minutes, and the recent frequency was 2-3 per week. Additional symptoms during panic attacks; hyperacusis and an urge to get home, although there was no agoraphobic avoidance behaviour nor any specific fear of being in places where panic attacks might occur. Previous treatments included chlordiazepoxide for 6 months once weekly psychotherapy for 4 years, relaxation therapy, and a trial of propranolol, all with minimal benefit. Her family history was negative. Her father died when she was 5 years old from heart disease and she was brought away from home from the age of 11 at various schools as her mother was severely handicapped with emphysema. She was not in a long term personal relationship at the time of presentation. Panic disorder was diagnosed and after 1 week’s abstention from caffeine she felt better and volunteered herself to abstain from caffeine. Treating her panic disorder with drugs seemed no longer appropriate. At 8 months follow up she continued to be free from panic and limited symptom attacks. She had remained on an almost caffeine-free intake. On 2 occasions when she took more caffeine mild anxiety symptoms recurred. All 6 cases had either GAD or PD. caffeine abstention improved symptoms in all 6 cases, in 5 such that anxiolytic medication was no longer required and in 1 where the dose of anxiolytic was probably less than would otherwise have been required. caffeine abstention patients should be advised of the short term withdrawal symptoms of increased headache, sleepiness and laziness and decreased alertness and activeness. High users of caffeine might be advised to taper their in-take over a week or two to obviate such withdrawal. (condensed slightly by Dr. K.S. Srinivasan) FURTHER ON COFFEE The oil content in coffee powder ranges rom 9 to 13%. Boiled coffee decoction extracts partially the oil present in coffee powder. When such decoction is drunk it effects what is called a hypercholesterlemic state among the consumers, i.e. the cholesterol level rises in the body system. The oil in the coffee bean is unusually high in unsaponifiable matter which is responsible for increasing the cholesterol level. In the ‘instant coffee’ the oil is removed in the process and in the ‘drip filter’ the oil is retained in the residue. Only boiled coffee extracts the oil which increases the cholesterol (Extract from Letter to the Editor, The Hindu, Madras, from G. Azeemoddin, Jt. Dir., TNTU Inst. of Chem. Tech. Anantapur. = K.S.S.) INDIFFERENCE, CATHERINE R. COULTER, The Hahnemanian, September & December, 1989. The Nature of Indifference : This mental state, defined by WEBSTER mainly in negative terms to portrary an emotional void, is actually a highly complex emotion, full of substance and fraught with inner tension. Its manifestations differ in the various constitutional types and according to the causes from which it originates. For instance, in Phosphorus indifference often takes the form of unresponsiveness, in Lycopodium of detachment, in Sulphur of egocentricity, in Natrum muriaticum of self-denial, in Sepia of lack of interest, in Lachesis of “switching off.” and so forth. Sometimes the indifference appears innate (Lycopodium), sometimes acquired (Phosphorus, Phosphoric acid), sometimes assiduously cultivated (Natrum muraticum, Staphysagria), sometimes a blend of the above (Sepia). In its purest form, indifference is a sickness arising from total physical collapse or mental shock, with no strength to care, and its addressed by such remedies as Phosphoric acid and Carbovegetabillis. but sometimes it is part of a curative process – offering the vulnerable individual a way to find emotional equilibrium and assisting him to become disengaged from unendurable reality. In these cases the physician will administer medium instead of high potencies so as not to disturb the defence mechanisms at work. For the action of the homoeopathic remedy is paradoxical: the one that can dispel an unhealthy indifference can sustain and encourage a curative one. The physician further learns to distinguish a true emptiness from one which masks an underlying vulnerability or obsession. And this latter state can, in turn, be subdivided into healthy versus unhealthy masking indifference – all of which forms will be examined below. However, sustained indifference, even when curative, is often unnatural. Feeling, caring, enjoyed, relating, being moved by interest or curiosity, are all integral to being human, and a true indifference, in the sense of emotional stasis, denies a vital aspect of the human experience. Even the “healing” (or “protective”) indifference, taking the form of self-renunciation or self-deprivation, entails a certain degree of withdrawal from life. And the individual who remains too long in an emotional void, lacking positive feelings risks replenishing the vacuum with negative ones. Forestalling this evil by extricating the patient from his slough of indifference and restoring him to a fuller state of existence becomes the physician’s prime objective. Yet another species of indifference is not a rejection of life, but only a rejection of overly powerful and uncontrolled emotions which endanger one’s serenity. It is the calm after an emotional storm, emerging when pain and bitterness have been exhausted, emotional injury and disappointment overcome, rancour and resentment dispersed. The patient has progressed beyond the subversive anger that tends to turn against him, beyond “extreme loathing of life” (HAHNEMANN-Sepia), and has arrived instead at an indifference that offers a way of confronting harrowing emotional ambiguities and softening rigidities of personality without risking a fracture. The task of the homoeopathic remedies may often be to help the patient arrive at this highly desirable state of poisa and serenity. The term “indifference” thus covers a range of functions, both curative and masking, emotions both healthy and unhealthy, and manifestations both desirable and undesirable meaning, in homoeopthy, that we have a large assortment of possible medicines. Apart from Phosphoric acid, the newest member of our portrait gallery, the following pages touch primarily, upon the finer shadings of several remedies already discussed in these Portraits. This selection merely reflects the author’s own observations and experience with cases exhibiting the emotional state called “indifference” and is not meant to exclude such remedies as China, Platina, Lilium tigrinu, and dozens of others which have also been found to benefit patients in whom indifference is a prominent symptom. Genuine Indiffernece Resulting from Physical Ailments or Mental Shock: A genuine indifference, in the sense of true emotional emptiness, can be provoked by such acute physical ailments as influenza, pneumonia, mononucleosis, malaria, typhoid, and others. The patient is left too feeble to muster a mental or emotional response. Carbo vegetabilis comes first ot mind for the utter indifference accompanying the state of collapse following a severe illness. The patient is aware of his surroundings but “hears everything without feeling pleasantly or unpleasantly, and without thinking of it” (HERING). He cannot “whip himself into activity or rouse a desire to do anything (and is ) unable to perceive or feel the impressions that circumstances ought to arouse” (KENT). These mental symptoms reflect one aspect of the well-attested Carbo vegatabilis “sluggishness” (KENT). But, overall, this polychrest suffers from a paucity of idiosyncratic or sharply delineated psychological traits. In addition to its picture of indifference and mental sluggishness, the sketchy mental picture of this important remedy is made up principally of variations of HERING’s memory feeble or temporarily lost .. with a tendency to fixed ideas; mental confusion making thinking difficult: and HAHNEMANN’s” out of humor, great irritability, peevishness; impatient after angry outburst of temper.” Another commonly prescribed medicine for indifference after an exhausting illness (influenza in particular) is Gelsemium. Here the mental “dullness, listlessness, and languor” (BOERICKE) correspond to the patient’s physical picture of droopy eyelids, heavy limbs, and complete absence of energy. And, in a perhaps fanciful extension of the Law of Similars, the state of both mind and body are reminiscent of the torpid, sultry languour induced by the intoxicating perfume of the yellow jasmine from which the remedy derives. Psorinum should also be considered for indifference arising from lowered vitality and lingering weakness in patient never fully recovered from some previous illness – a “never cared since” syndrome which parallels the “ never well since” syndrome discussed in an earlier chapter. Phosphoric acid is another viable candidate for total indifference to his surroundings. Although BOERICKE says of it, “mental debility comes first, followed later by the physical”, many physicians find it useful in cases of indifference following a debilitating physical illness, where the patient simply has too little energy to care. Indifference can also result from severe mental shock – after a fright or overwhelming sorrow. The immediate aftermath might call for Aconite or Ignatia But once the initial shock has been overcome, Opium with its “ailments that originate from fright” (HERING) or Phosphoric acid, with its “system (that) has been exposed to the ravages of grief and loss” (BOERICKE) are frequently resorted to. Opium’s stupefaction (and ) indifference” (HAHNEMANN) is easily recognized by those familiar with the effects of opium and other opiates (“complains of nothing, wants nothing; tranquil indifference to earthly things” (HAHNEMANN) and requires no further clarifying examples. But the Phosphoric acid indifference that descends on the patient who has undergone the shock of grief, chagrin, or disappointment in love: (HERING) does call for elaboration. Like a stone thrown into still waters, after the initial shattering, the emotions spend themselves a series of ripples of decreasing intensity, and Phosphoric acid is a major remedy for these peripheral reverberations. Thus it better fits the second stage of emotional trauma, when acute shock has become a “settled despair” (BOERICKE) that may take the form of indifference. The Phosphoric acid patient is quiet and seemingly unperturbed. Although he might appear absorbed, in reality no feelings or sensations smolder beneath the surface (“no howling emptinessinside,” as one patient put it). He is adverse to conversation and unable to react appropriately (“speaks little and answers unwillingly the questions put to him”; HAHNEMANN) – not because he is sullen or out of humor (although he may “look very illhumoured and sullen”; HAHNEMANN), but from a sense of futility. No comment is adequate to the trauma he is undergoing or has undergone, and no one who has not experienced a similar grief can understand it. He does not permit himself to fee, les he reopen old wounds and rekindle the former pain. He will dutifully go through the required motions of living but appears abstracted – almost in a dream. Or he will sit numb and dazed, staring vacantly into space. He might tell himself to clean the house, work in the garden, or vist a friend, but then appends, “Why bother? Why pretend to care? Nothing matters any more… “In extreme cases he takes to his bed, lying motionless, “like a log, utterly regardless of his surroundings” (H.C.ALLEN), and unwilling to be disturbed. Phosphoric acid, however, may also be indicated for the polar opposite of indifference – the overt forms of grieving where the patient is visibly torn asunder, uncontrolled dand frantic (“hysteria”; HERING; “restlessness.. weeping.. hurried talking”; HAHNEMANN). A woman of fifty, diagnosed several years earlier with multiple scierosis, suddenly realized that her condition was incurable. She had been valiantly ignoring it and trying to live normally, but her progressive physical disability now caused her continually to trip and fall. In the last few months she had gone from a cane to a walker, and was now confined to a wheelchair. Her back hurt continuously; at right she had severe tearing pains in the legs; she had neither bowel nor urinary control; and her clumsy fingers could not open jars or bottles, or even hold objects without dropping them, Her tongue, moreover, was so thick and inagile that she sounded inebriated when she spoke. Hence she had totally lost her composure and came to the physician sobbing in terror and despair. Ignatia was initially prescribed for her hysteria, and several other remedies were tried, but the case was really turned around by Phosphoric acid 200c (in weekly doses for a month) with its two rather colorless supporting symptoms: “better for warmth of bed and warm food” (HERING). Today, ten years later, the patient has not been cured of her degenerative disease but has very definitely improved. She can walk with only occasional use of a cane, has really full control of her bowels and urine, talks normally, and has recovered more than eighty percent of her manual dexterity. She receives constitutional remedies at least monthly to maintain her improvements, and if she relapses into overt fear and hopelessness, Phosphoric acid invariable comes to the rescue. Worth mentioning, in connection with this case, is that Phosphoric acid, with its “extremities weak and greatly debilitated; tearing pains in joints, bones, and periosteum; stumbles easily and makes mistakes, “and Picric acid (TNT!), with its “great weakness of the extremities, tired heavy feeling all over body, especially the limbs; acute ascending paralysis” (BOERICKE), are among the half-score or so remedies that have proven exceptionally valuable in multiple sclerosis. Phosphoric acid is another important homoeopathic remedy (cf. Carbo vegetabilis, above) that is not endowed with a well-developed or clearly defined personality, Although possessing a rich and varied collection of physical symptoms, its mental and emotional picture is rather meager – always overshadowed by the related, and more colorful, Phosphorus. HERING has summarized the Phosphoric acid personality in a few key traits: “unwilling to speak listless, apathetic; remarkable indifferent to everything in life… weak memory; loss of ideas; weakness of mind; cannot collet thoughts; cannot find the right word when talking; answers reluctantly and slowly or shortly and incorrectly. “Later textbooks of material medica merely reiterate this picture, or elaborate on it, and the prescriber must rely largely on the physical symptoms and supporting modalities. Yet, in its power to dispel the indifference resulting from despondency, negativity, lack of interest, or emotional emptiness, to restore the physically exhausted or emotionally depieted patients’ vitality and ability to care; also in its capacity to enable the despairing patient to acquire a SAVING indifference, and the stoical one to sustain his mental equilibrium through mental and emotional strain Phosphoric acid has earned its rightful place among the homoeopathic polychrests. The Masking Indifference: Often the indifference is not genuine but merely feigned – a sheath concealing some underlying drive, fear, or vulnerability. The aim is not to deceive. The mask of indifference helps preserve self-control and maintain emotional stability, it serves to contain an otherwise consuming emotion. It also signals to others that this reserve should not be violated but be respected. Phosphoric acid plays a major role in all these instances. A representative case was the middle-aged man suffering from arthritic pains of recent onset who, with the noblest intentions in the world, could scarcely tolerate the chronic infidelities of his attractive young wife. His love for her and their two young children, together with his innate stoicism, enabled him to conceal his pain behind a mask of indifference, and his calm disposition, seemingly incapable of rancour, helped him appear unperturbed. Only his sorrowful, pleading eyes – those of a dog gazing imploringly at his master and unable to express his pain – betrayed his true feelings. Although he forgive his wife in his hear and appeared indifferent to her behaviour, his body possessed a will of its own. Expressing its grief through the pain in its joints, it refused to allow his to ignore the repeated injuries to his psyche. Being closely related chemically to Phosphorous, Phosphoric acid has the same affinity for the bones and joints – with “tearing,” “burning,” “boring,” “digging,” or “cramping” pains – and this remedy was prescribed (In medium potencies) with gratifying results the physical pain vanished, and even the emotional trauma became more tolerable. Admittedly, other homoeopathic remedies are available to assist patients who conceal their injuries under a cloak of indifference, but whose unforgiving and unforgetting body develops pathology in consequence. Natrum muriaticum is a prime example – hiding his sorrow under a beaming smile so as not to burden others with his interminable difficulties (“No, nothing’s the matter .. Yes, I’m perfectly fine?”) or maintaining a stoic front and stiff upper lip to prevent his feelings from becoming too real. Prominent here, too, is Staphysagira – whose masking indifference conceals even from himself the emotional origins of his bursitis, rheumatism, sciatica, tendonitis, or whatever. Sometimes, in fact, the patient recognized the emotional basis of his illness only in hindsight – after Staphysagria has been successfully prescribed and helped to cure his physical condition. A typical case was the woman with a persistent sciatica which resisted all pain-killers, After trying every conceivable medical test, including a CAT scan, she eventually turned for help to homoeopathy. At first she was treated with such conventional sciatica remedies as Rhus toxicondendron, Hypericum, and Colocynthis, but when these proved unavailing, the physician inquired more closely about her family. Underlying her condition, as it turned out, was an anger at her son’s school teacher, who was critical of his behaviour and insensitive to his needs. She disguised this by a cavalier indifference (“So, she’s incompetent. I suppose she’ll be out of his life after this year !”), but her body did not allow her to suppress this resentment and asserted itself in no uncertain terms until the situation was righted by Staphysagria. Such are the psychic depths addressed by the homoeopathic remedy even without the patient’s conscious participation. Without forcing him laboriously to examine the distressing present, or to disinter and relive the traumatic past (in this case, it was the excessive parental criticism the patient had been subjected to in childhood), the Simillimum proceeds to disperse their untoward consequences. Indifference to Everything in Life: “Indifference” in the KENT Repertory has a number of subrubrics. We begin with the one which is broadest in scope – “indifference to everything in life.” This state is akin to ennul, that mental weariness and overall dissatisfaction with life which in former years was regarded as a malady of the leisured class but which today, under conditions of democracy, is shared equally by all. The patient does not display a Hamlet-like loathing for life out of intellectual Angst or ambiguity, nor yet a Werther-like tedium vitae out of sorrow or despair, with active desire for death; his attitude is more defeatist, his mood is calm, but his outlook is somber. For this condition Phosphoric acid is a homoeopathic mainstay. It befits the patient with complete lack of interest in his surroundings. Even when young, he is so fatigued in spirit, so firmly convinced that pleasure, success, affection, and excitement are not for him , that he has ceased striving for happiness or meaning in life. It is not a sense of grievance that deprives him of responsiveness but rather a settled discouragement and demoralization – dispirited reaction to his environment. He displays no urgency, no desire for accomplishment, no impatience to overcome his mental stagnation – to move out of his emotional limbo. “I need time to remain Ill ..I haven’t the energy to start getting well … I have to stay in this apathetic state a while longer…. please don’t force me!” – are his more typical supplications; and “I don’t want any of your remedies. I refuse to be potentized!” – a more unusual one. A man of the church, who had returned weak and depressed from a tour of the Third world in an official capacity, was loath to resume his parish duties. While the diarrhea he had contracted in Africa was debilitating enough, something more subtle and profound than any physical ailment had transpired during his trip. Witnessing so much poverty, illness, starvation, and suffering in his enfeebled state had undermined his faith, and he was now quite indifferent to the spiritual welfare of his American flock. He saw no point in continuing his mission on earth. He had, in short, given up: “I feel that I have passed the summit of life; from now on th path goes only downhill.” The minister’s uncharacteristic. but now engrained, indifference was so startling that a friend recommended that he try homoeopathy. On the basis of his continuing diarrhea (prominent in Phosphoric acid), and also by virtue of the modality “worse when walking out of doors, better form sitting in the house” (HAHNEMANN), one of the remedy’s few idiosyncratic symptoms, it was prescribed in the IM potency. The effect was spectacular! It not only restored the clergyman’s former optimism and happy disposition but accomplished the more formidable task of renewing his faith in an ultimately merciful (even if His ways are not always comprehensible) Deity. The Phosphorus “indifference to everything in life” presents an even more striking contrast to the type’s usual liveliness or joie de vivre. Sometimes his lack of response reflects an overall satiety with life’s pleasures, after having burnt the candle at both ends – and in the middle. At other times the “strange, rare, and peculiar” aspect is the sudden loss of his former attractive enthusiasms. A homoeopathic physician in his mid-thirties who was relatively new to th trade suddenly lost all interest in life - including family, friends, hobbies, even (difficult to believe!) his profession. His former ebullience and eagerness to follow the homoeopathic method had turned into a profound despondency (“the whole world seems dreadful to him”; HAHNEMANN) and was later moderated to a less alarming listlessness (“afterwards total apathy”; HAHNEMANN). When he finally turned to a colleague for assistance, the latter had no difficulty arriving at the root of the problem. Some years earlier this fledgling doctor had been converted to homoepathy by one of those energetic and charismatic leaders periodically spawned by this movement, who sat themselves up as more than mere teachers – rather as “master” or “gurus” – and thereupon develop a strong and devoted following. For a few years this patient had been the favourite son, a privileged position which sustained him in his studies and his work. But when he was duly superseded by a younger disciple, the light of his enthusiasm dimmed and was finally extinguished altogether. He no longer had the heart to seek the company of his former colleagues, or even to practice homoeopathy, and became quite indifferent, or even to practice homoeopathy, and became quite indifferent to life. Phosphorus is an enthusiast and, like many enthusiasts, requires an outside force to nourish and sustain his interest (the Phosphrous personality, we recall, may lack a clearly defined core or sense of identity), and in these cases his enthusiasm is a weakness rather than a strength. When this nourishing force withdraws, he is lost and empty, unable to function on his own. He then laments the “master’s” unsubstantiated promises, which are no less meaningful to him for being largely tacit, and feels rejected and bereft. Furthermore, because it is an “outside” force that he has never fully understood, he is confronted with the pain of disillusionment in a God (who “passeth human understanding”) that has failed. Such was this patient’s predicament. he has dosed himself with Aurum metalicu, Ignatia, Natrum muriaticum, and other remedies, but he started slowly to pull out of his debilitating mental state only when Phosphorus was prescribed – largely on the contrast between his present indifference and his former strong enthusiasm. He eventually resumed his former practice – in a quieter mode but this time with truer inner strength. Natrum muriaticum can be equally indifferent to life after some painful disillusionment or loss of enthusiasm but has another mode of reaction. He seldom abandons completely any activity involving an element of duty and thus, despite his current apathy, joylessly goes through the motions of what was once meaningful. Hence his indifference is burdened with more subliminal anger and resentment than that of Phosphorus, Phosphoric acid, or Carbo vegetabilis. However, it is rarely maintained with any consistency. Rather it alternates with spells of diligence, animation, and resurging enthusiasm, and this all contributes to the type’s well-known mood swings and sudden reversals of taste and opinion. Although Natrum muriation might be genuinely indifferent to his own life or welfare, he is not indifferent to death. While perhaps welcoming it in the abstract, he cannot be apathetic about leaving the world improperly attended to. who will set things right once he has departed? Hence he must stay around – at least until someone equally farseeing and responsible materializes to take over his important duties. What is more, when he does recover from a debilitating indifference, he embraces life with the eagerness appropriate to one miraculously vouchsafed another opportunity of assisting a world in travail. Lycopodium presents quite another picture of “Indifference to the highest degree…. insensibility to external impressions” (HAHNEMANN). Ever skeptical of emotion and both relativistic and ambivalent in his perception of the world, his apathy seldom proceeds from lost enthusiasm but is rather an off-shoot of his innate detachment. He bot instinctively and on principle repudiates whatever jeopardizes this detachment; any enthusiasm, eagerness, or too-strong emotion. A case emblematic of Lycopodium’s principled reluctance to betray enthusiasm was the lady gardener whose gowing indifference to life had been exacerbated by a mid-life depression. when challenged by a friend to react to a beautiful be of geraniums, she replied; “I don’t find this flower bed the least bit interesting. But perhaps the fault lies in the geraniums themselves and not in my own apathy. Uninspiring flowers at best, they do not grip the attention of even the healthiest individuals.” The Lycopodium characteristic is not easily analyzed but is best appreciated in context. Another instance is his way of reacting to another’s excited concern with a cool “Does it really matter?” Indeed, in cosmic terms, the event might not really matter, but it was not seen that way until Lycopodium placed it in perspective. Or, when told that some undertaking is bound to be “unforgetable,” Lycopodium may remark wryly, “That is certainly possible!” The implication, of course, is that the experience may well match the enthusiast’s expectations, but not necessarily in the way desired. Such laconic, even-tempered skeptcism could be viewed charitably, as reluctance to take too seriously his own or another’s feelings-a healthy characteristic when not accompanied by emotional withdrawal. Those less partial to the typical Lycopodium aloofness ascribe this “indifference” to an unyielding desire for psychological mastery. In Calcarea carbonica “Indifference to everything in life” carries a note of resignation. In sickness this can appear as “Indifference about his recovery” (KENT) with loss of all desire to fight illness. If there has been much physical pain and suffering, the remedy is often Arsenicum album (“carelsss about approaching death, neither hopes nor wishes to recover”; HAHNEMANN). In health he may refuse to worry about the morrow; “What will be, will be”, states he with oriental fatalism, “Sufficient unto the day are the problems thereof.” Thus he resists the modern tempo of haste and urgency and handles all conflicts and ambiguities through a placid indifference. Tracing back through the case history, the physician may find indifference rooted in disappointment that some anticipated event did not occur, some long-awaited change never came to pass. The patient has relinquished hope and become indifferent so as not to be disappointed second time. It is not only older persons, who may have outlived the need for passion and intensity in their lives, who suffer from phlegmatism and inertia, but younger ones as well. This state compares with Sepia’s emotional “stasis” (FARRINGTON), but without the latter’s “Soured” outlook. Calcarea merely exhibits a preference for rest over motion. even if (since life is motion) this entails some denial of the itself. OBLOMOV, the archetypal Calcarea carbonica figure mentioned by us more than once in these Portaits, represents this indifference to everything – the man who wishes sonly to be left in peace. To achieve this he will sacrifice love, friendship, accomplishment, and even self-respect. This Calcarea indifference, that neither condemns nor condones the surrounding world, does not repudiate life generally but simply sets little value on his own. A kind and sensitive, but lonely, Calcarea soul suffered from dizziness, constipation, poor sleep, tension in the neck an shoulders, heartburn, and low self esteem. In her marriage she had long resigned herself to second class citizenship, and now, with her children grown and gone, she was also suffering the particular loneliness of the “empty nest syndrome.” Her life offered no tragedy or trauma, merely stagnation and an unclear picture of how to use her potential. She had withdrawn into her shell and was “indisposed to talking, without being ill-humoured” (HAHNEMAN). Mindful that at times this type can be jogged out of passive indifference only by some external stimulus, the physician in the full and august majesty of his authority, instructed her to adopt a kitten and two canaries. This mandate, reinforced by a prescription of the potentized oyster shell, accomplished the desired physical improvement. And there was even some mental improvement, as even from her remarks a few months later; “Certainly at birth we are dealt a weaker or stronger hand, but I now realize that this does not justify a fatalistic indifference to the game being played. The Challenge lies in how you play your cards, in scoring as many tricks as you can. A not-too-original discovery, to be sure, but one which in my apathy I never really absorbed until now “she sighed.” I suppose that, with the kitten now fully grown and the canaries singing away contentedly, I sall have to decide how to play My hand better. But, oh, my! What a daunting prospect!”. The Staphysagria “indifference to everything in life” usually follows some injury or insult which the conscious mind is willing to overlook but the implacable physical constitution has no intention of letting go by. A young woman, temporarily institutionalized for a nervous breakdown, was unable to pass urine without a catheter. She ws the picture of indifference, sitting un-reactive and unresponsive and staring all day out the window. Her urinary retention, which had commenced in the hospital immediately suggested Staphysagria, and closer questioning revealed the presence of suppressed indignation. Her room had no doorknob on the inside, and she had been furious at the indignity of being so incarcerated. After carrying on about it for two days, her passion spent, she relapsed into indifference, and had refused, or been unable, to urinate since that time. Three doses of th remedy in high potency, administered at twelve hour intervals, released both her urine and her anger. After this outbreak of emotion she became anxious to be released from the hospital and, in consequence, became cooperative and mad a speedy recovery. Sepia and Sulpur, two major remedies in this particular subrubric, are accorded much coverage in the following sections, Here we need only state that Sepia’s overall indifference (“Very indifferent to everything: the death of a near relative or some happy occurrence leave her equally unaffected”; HARING) – for which previous trauma or sorrow cannot always be established – often merely reflects a chronic physical lethargy and prostration that renders her incapable of feeling (“lies (indifferent) with her eyes closed.” KENT). Sulphur’s indifference to everything, on the other hand, usually strikes the physician as a temporary unnatural state in glaring contrast to the individual’s customary assertiveness. HOMOEOPATHY AND MIND, BAUER, E. ZKH, 30, 2& 4/1986 Patient 1 : On a Monday a couple came to me for a ‘fasting treatment’. On the following Thursday the wife said; “we must go back home by Saturday at the latest, then…” and laughingly looked at me. It was about her dog. He was sad, just lying at home with total apathy, without eating or follows: the dog had been at one time, gravely ill. Her husband had brought it up with love and care. Both of them were inseparable. This time her husband had, for some reason, not taken leave of the dog when he went away. The dog did not find him any more. a single globule of the size of the poppy seed of Ignatia XM was sent by speed post. It was sent by speed post. It was given to the dog at 2200 hours. On the following evening the telephonic inquiry revealed that since that morning the dog had recovered to its earlier state. He is cheerful, eating and drinking. The argument for the exclusive use of the deep potencies and the indisputable success of the homoeopathic high potencies and Homoeopathy itself in general is, according to opponents of Homoeopthy, the faith which the patient places upon the personality of the physician. The success with animals particularly when the physician had no chance to see the animal, rebuts this. The other objection is chance. Now that is totally rebutted when, for example, we cite a series of 4 continuous similar cases of animals in which immediate and permanent effects were obtained. Ignatia is one of our wonderful and reliable medicines, specially indicated in those overwhelmed by sadness and grief. An elderly woman lost her husband. She is sleepless, lost her appetite, overwhelmed by grief, Ignatia XM transformed her strikingly. Only apainful remembrance remained. In this case Ignatia XM was given one hour before the burial for the second time and generally five days later same potency for the third time. Patient 2: A music teacher who an year ago had cared for her mother till her death an dhad witnessed the tormenting agonies of death due to cancer, felt since an year, simply unwell. Her constitutional remedy was Silicea and it had earlier relieved her asthma, her recurring bronchitis, her disposition to catarrhs as also her unendurable anxiety for appearing before public which was necessary in her professional practice. She got over all these but since an year things were not progressing forward, she did not feel well, complained of all kinds of ailment, Ignatia XM restored her well-being again and later Silicea worked better again. Patient 3 : On 23-09-1959 a then 47 hears old Foreman came to consult me. His wife had telephoned to me already before his arrival. She was afraid that he had cancer. Her husband spoke little, was always serious, depressed, did not laugh, little appetite and since an year had lost about 6 kg. weight. The man was pale, taciturn, emaciated, answered in monosyliables and not a word more when interrogated. it was, however, learnt that he felt well until 4 years ago. Since 4 years no courage to face life, nothappy with anything and less appetite. During methodical interrogation, to the question; “Have you sons?” we learnt that his only son died in an accident. “When?” “Four years ago.” The right pupil showed flattening at 12 hours and indicated the deep mental depression, indeed the so-called “asthenic form” (while in right eye). These people hold their grief within themselves, could commit suicide before anyone had event the premonition, to the great surprise of those around. The Patient had the following symptoms: 1. Aliments from grief. This symptom takes the first place because it is the causative one. 2. Silent grief. This rubric contains Ignatia, Natrum muriaticum in highest, Pulsatilla in 2 grade. 3. He is uncommunicative, keeps his grief to himself, shared it with no one. Cyclamen in 1 grade, Ignatia in 2 grade, Uncommunicative : Ignatia is 2 grade. 4. Consolation aggravated : here Ignatia was in high grade. So in this case Pulsatilla is excluded. 5. cannot tolerate contradiction: again Ignatia in high grade. The patient received Ignatia XM and left my clinic relaxed and laughingly. Report 5 weeks after the single dose; health excellent. Has even improved which was not the case since years. Report after 3 months after dose; since 14 days again unwell. Now he received the second dose of Ignatia XM. Since then in good health. I saw him 4 years later fro rheumatism. The flattening of pupil of the right eye was gone and so also the symptom “consolation aggravates.” Again 3 years alter I heard from him. He suffered from fever with bronchitis. Since then asthma and cough, both unceasing, day and night. He was, just now, in hospital and despite the medicines prescribed had not benefited. I was again asked to take the case since his agonizing condition was intolerable. I received him during my usual clinic time with a room full of patients. He received a dose of Ignatia XM, Why? 1. Because the medicine had helped him so good. 2. Agonising, woebegone appearance, the heavy and shattering cough and the asthma had something dramatic about it. 3. Because the eihe point for Ignatia was clearly positive. 4 Above all, because I had not much time then for him. I had little hope of success with this lightening like remedy choice and told him so and recommended him to begin a fasting treatment so that we will have sufficient time to retake his case with all the detailed symptoms and prescribe. But with the dose given the patient felt undoubtedly well; cough and dyspnoea went away. Report form his daughter few months later; free from complaints. An Ignatia – symptom which has proved effective in grown-ups is what BORLAND (Children’s Type) explains: Tensed appearance: “When the child speaks there is a strained tensed appearance of the facial muscles, to the extent of definite grimacing.” Our patient had this tensed appearance. Regarding symptom “Consolation aggravates”; If it is clearly present, it is a valuable symptom as we have seen. the opposite “Consolation ameliorates” is not a peculiar symptom but is a normal state. At the same time, if a total amelioration strikingly occurs as also physical symptoms are relieved through consolation then only Pulsatilla has it and in 2 grade. “Consolation aggravates” is one of those small list of symptoms which when it is very strongly present, excludes Pulsatilla and Phosphorous. There are exceptions. My teacher Pierre SCHMIDT cured a young physician suffering from lung tuberculosis with 7 old cavities. The cases has been seen by tuberculosis specialists. With Pulsatilla XM improvement began to set in, the fever passed off and temperature became normal. An year later the lung collapse could be thoroughly treated. These lead to total cure without a single allopathic medicine. The young physician indeed showed aggravation from consolation but all the remaining symptoms indicated Pulsatilla. Pierre SCHMIDT has in his KENT’s repertory, added Syphillinum in high grade under the rubric “Consolation aggravates,” FOUBISTER Carcinominum and the extraordinary KENT pupil DELMAS the remedies Sabal, Sulphur and Kalium sulphuricum. All these additons are very valuable, I have found. Patient 4 : On 20-3-1952, Mr. H.F. a worker in neighbouring village consulted me. Since 3 weeks sensation of pressure in stomach, a strange sensation in the region of heart, poor appetite. Since 3 months poor sleep, cannot go to sleep, tired, often almost trembling of whole body. Within the last 2-3 months has lost 7 kg weight. Besides these he complained of his jealousy which has been there always. his wife suffered the hell with him because of his jealousy. She was on the point of leaving him and he held her. If his wife just only looks at another man, he quarreled with her the whol day, upset her with the bitterest reproaches and he knew very well that she did not deceive him, that she remained true to him, but he could not be otherwise. He received a dose of Lachesis XM (Korsakof). One week later: until now better in every way, however, today again jealous. Three weeks after the medicine: jealousy is relatively better. Again pressing sensation in stomach. On 20-4, that is one month after the medicine: The jealousy has gone. The unpleasant sensation in the stomach has almost become better. Appetite improved. One month later: Further improvement. On 11-8, I was called at my house in the morning at 5 hours because of lumbago. I treated it then shudder to say, allopathically. Three days later, the rheumatism was still bothering and so the patient received the second dose of Lachesis XM, Since 4 weeks the jealousy had been slowly coming up again and increased. On the next day after Lachesis the patient felt very much btter, cheerful. I saw the patient again any year later this time because of slight Angina and in the course of the following 6 years, approximately once an year because fo sudden, passing, rheumatic attacks. Now I meet now and then his relatives. The jealousy has not recurred again and Lachesis had not to be given for the third time. How would I proceed with the case now? The loss of weight of 7 kg. within a period of 2-3 months calls for special tests beside the usual ones. In my own laboratory it is possible to check neuroaminoacid reaction from the patient’s serum. It gives only one indication. f it were doubtful or bad then according to Prof. NEUNHOFFER treatment through Hydroxylamine reaction is called for . This is by far the most certain symptom of early reaction for cancer. It is examined in the urine, it can be well handled by our method of treatment. The peculiar sensation in the heart region would require the proving of Mozer’s point, especially the interaction of the left medicolavicular line with the second intercostals space which is the place to demonstrate it, that the source of the trouble is in the heart. Rheumatic ailments in the precardial region of simple heart involvement can be differentiated from it. The first one is healed easily by us through Homoeopathy without making any great changes in diet which is essential in the second case, and proceed to succeed. Since the new disease was only of 2-3 months duration we may be right to give the ‘acute medicine’ in the first instance and thereby hopefully remove the new disease rapidly. Following it we may search for the jealousy which has been there all along. The acute medicine is chosen on the basis of the newly come up symptoms and of cours if we are able to perceive it, keeping in view the causative factors. Entirely different will be the method for the choice of the constitutional medicine for the patient which is essential in respect of all ailments which persit for six months or more. We then choose the medicine on the basis of the totality of the symptoms. We mean thereby not just the later and present symptoms but the earlier ones also. The sicknesses which the patient had suffered, also his parents, grandparents, uncles and aunts and brothers and sisters are all taken into account (Tuberculosis, Cancer Syphilis). Finally we methodically examine in a planned way with about 100 questions in the Pierre SCHMIDT Questionnaire. What is necessary is there would be no haste, the patient should be least interfered with, to hear him patiently. The sequency in which the questions are to be asked is also important. The questionnaire of Pierre SCHMIDT begins with the so-called ‘Generals’, that is, the general symptoms, the attitude, reaction of the total patient to warmth and cold, seasons, thunderstorm, sun etc. Only then-after the patient had rapport with us in the meantime after he had seen that we are genuinely working to help him and that the system goes into the totality – do we venture to enquire about the mental domain. The first of these questions is: What was the greatest grief in your life? The second: What was you greatest joy? These two questions are very essential because they help the patient open up to us and give out. Questions regarding sexuality comes last and questions which are unwelcome to the patient are kept for a later interview. It is also good to inquire about the spouse in confidence, when alone. You avoid this because it makes the patient sad? Not correct. Instead in cases where there are marital discords you will get a useful word about the partner. To convey this word, naturally only this, later, at the right moment. It has always impressed me how in seconds the hatred in love turned up, particularly if the patient already ticked well with us. In respect of the case reported above all these have been left off. The remedy choice rested upon the reportorial segments: We have: Jealously: Hyos., and Lach. are in highest grade. The Apis, Calc.s., Cench., Nux v., Puls. and Starm. in second grade. Further complients: jealously, as foolish as irresistible: Lach. is given as the only medicine in second grade. Further, quareisome from jealousy: Cench., Lach., Nux v. The case of Mr. H.L. is a typical example before us, how one should not make it. But Homoeopathy is generous. It gives us only the Similie where we are perhaps unable to find the Simillimum. Patient 5 : Years later came to my clinic the young Mrs. Ruth. She is the eldest daughter of the above cited patient. Since sometime ago she has been married, Modest, Hesitant, she was before me bashful with flushed cheeks. She complained of jealousy. And how ! if her husband just only looks at another women or danced with any one, she would then reproach him the whole day. Now, she is the eldest daughter of Mr. H.L. and we know that eldest daughter is almost similar to the father, wholly seldom the father’s sister. Just as exactly as the eldest son almost like the mother, seldom like the mother’s brother. The constitutional medicine of the patient was Pulsatilla and it healed of her jealousy. Patient 6 : Totally unusal form of jealousy in an entrepreneur which was responsible for insignificant occupational experiences. I am not able to recall now his name and am unable to therefore pick up his record but the peculiarities are recalled. 12 years ago he had married. He soon learnt that before the marriage his wife had gone on holidays in the company of a man. His wife clearly explained that they had only a platonic friendship. Her husband did not think so and the thought as to what could have happened in these two weeks tormented him all these 12 years. yes, this idea possessed and tormented him. He neglected his business at times, spoiled himself by boorish behaviour with his clients, considered committing suicide and constantly pestered his wife to confess. His constitutional medicine was Nux vomica. Some months after treatment, I think after the second dose of Nux vomica XM, his wife told that her husband was likd a glove. He was completely well. I have not, since then, heard from them. The favourable action was not the last. it is not possible that Nux alone could heal a chronic and deepseated psychotic complaint and for that this apsoric plant medicine is less deep. The nosode Tuberculinum was fore seen as soon as Nux was not satisfactory. The severe, hatred-filled character of the man would be suitable for this nosode. Also in mental disturbance we think of this nosode. In KENT’s Repertory we find the rubric ‘malicious’ with Nux v and Stram. in highest grade. Pierre SCHMIDT has added Tub also in highest grade. And to the rubric threatening’ he has added tub. in 2 grade. These addition to KENT’s repertory by Pierre SCHMIDT is based on reliable sources (mostly HERING, HAHNEMANN, ALLEN) and his own experiences over many years. How is it now with our Enterpreneur? We have seen that the second dose of Nux vomica XM opened up its action. There are two possibilities. 1. It works at least for 5 weeks or longer. That is, the well-being becomes worse after 5 weeks or later. We do not then alter the medicine. Since a third dose of the same potency does not work as a rule satisfactorily we proceed to the next potency according to KENT’s steps and that is Nux vomica 50 M. 2. It is assumed that the second dose of Nux vomica XM works lesser that 5 weeks, that is, too short. The medicine does not then work deeply. There are hindrance from the chronic miasms which Nux cannot overcome. Now we set the nosode. We give Tuberculinum XM. In case of 1 above three things are possible: (a) ux vormica 50M one dose works at least for 7 weeks. Then we give Tuberculinum XM when the improvement regresses. (b) The dose of Nux vomica 50M shows no perceptible action. We wait for 14 days more and the give Tuberculinum XM. In (a) we remain with Nux vomica, according to KENT’s potency steps, of course until this medicine works satisfactorily. In (b) and (c) there are three other possibilities: 1. With Tuberculinum XM there is relief and it continues for 5 weeks or longer. Then we give the second dose Tuberculinum XM when the improvement lags. 2. The amelioration is lesser than 5 weeks. Then we give the second dose of Tuberculinum Xm despite it being within 5 weeks after the first dose and after another 5 weeks Nux vomica 50M. 3 There is no perceptible amelioration fro Tubeculinum XM. Then 5 weeks after the first dose of Tuberculinum XM the second dose Tuberculinum XM and wait for another 5 weeks. If no perceptible action is forthcoming we give then Nux vomica 50M. Evidently Tuberculinum has cleared hindrances which stood in the way of Nux vomica. In 1 since Tuberculinum alone acted perceptibly for a sufficiently long time we hold on to Tuberculinum as long as this medicine acts satisfactorily adhereing to KENT’s scale. KENT’s scale is : XM, XM, 50M, CM, DM, DM, 1MM, 1MM. What do we mean by satisfactory action? Progressive amelioration with every scale of potency for characteristically least period. These are : for XM 5 weeks, 50M, 7 weeks, CM 3 months, DM 6 months for the first tie and 4-6 months for the second time, for the MM 1 year. Pierre SCHMIDT gave addition to the KENT rubric ‘Jealousy’ on the basis of GALLAVARDIN as following: highest grade for Nux v., and Lyc., and Staph, in second grade. In Repertoire de Medicine Psychique of GALLAVARDIN we find “Jealousy, Criminal” hyos., Lach., and “Consequence of jealousy”: apis., hyos., nux v., and puls. Patient 7 : 33 years old engineer. He is a homosexual. We can also say bisexual because he also loved at the same time a girl and it is his desire to raise a family. Sulphur quickly improved his disposition so much that he could venture to marry. He remained under treatment because his “temptation”, as he put it, rose to the surface again but lighter and more rarely. He came under my treatment on 26-11-1960 and he looked very pale. Earlier he had frequent Angina. the tonsils were removed. Family history of Cancer. He remained under infrequent doses of Psorinum and Tuberculinum, 3 years under sulphur. After this the symptoms indicated Psorinum. Now he remains cured. He looks better, improved efficiency, increased vitality and mentally very clear and bright. Patient 8 : Chauffer 31 yearrs old. He was sentenced for 3 years for his preference for small boys. After one year he was released on parole without his sickness having changed. Therefore his prosecutors had to shut him in again. Sulphur was the constitutional medicine. It improved him quickly but for another year small boys were dangerous to him although as year by year it became lesser and lesser. Simultaneous with the mental defect his physical complaints like rheumatism and eczema were improving. The vitality of the patient improved continuously progressively which was visible in his younger looking face so much more as the treatment progressed. It must also be remarked that now we are dealing with a bisexual conduct. The patient has since been married. Patient 9 : Lady teacher, 22 years old, lesbian disposition, with every fibre of her being indeed, as she said. Extremely passionate. Never has she had the least sensitivity to the other sex. Her constitutional medicine is Sulphur. Yes, in this case we have the entire picture of the remedy before us. Amongst many other symptoms she had: “sadness in evenings, in bed,” Four remedies have it: Arsenicum, Grahphites, Stramonium and Sulphur, She received on 9-3-1963 : Sulphur XM 21-5 report : Felt well. 4-6 report : Iesbic disposition normally improved. 21-6 report : for the first time in her life she was thinking of ‘man’! She began to improve in the respect. She has not of course forgotten girls. Her chronic cold occurred this year only very mildly (In the earlier years it was severe) 10-8: Since 3 weeks relapsed with a girl friend; Now the second dose Sulphur XM, that is 5 months after the first. 11-9: Further improvement. Her dispositions are changing progressively. 5-10: Improvement is continuous although slowly. I did not hear from her further. Probably there was a relapse after the action of Sulphur XM became weaker. Patient 10: This young businessman was also similarly disposed towards same sex exclusively. In this case, Lachesis chosen on the basis of the totality of his symptoms, brought about a slow change. For the first time in his life he began to get a progressively increasing liking for the other sex. But in this case too, just as in the previous one, our contact ended suddenly and in some ways similarly. In the repertory we have the sction: “Love with one of own (feminine) sex” and find therein Lach and Sulph. In smaller grade. Pierre SCHMIDT has, in this section, put Plat, in the highest grad and added Cal. in the smaller grade. To summarise: Homosexual tendencies react positively to homoeopathic constitutional medicines. We know this from GALLAVARDIN. But the inveterate cases require spiritual guidance. Together we can, in the future, alter these patients. When they do not report to us, we must go to them. “If the mountain does not come to Mohammed, then Mohammed goes to the mountain.” Patient 11: The Marriage Counseller referred to me a 37 years old Production Engineer, Since 2 years he suffered from attacks of rage while in house, During those moments could kill his family, he told me. His wife assured that he was generally an affectionate husband and father. but those attacks of rage were so terrible for the family that they approached the Marriage Counsellor. The complaints began 2 years ago. The Engineer, then, had mad a name in the automobile manufacturing fabrications and its economic and he had a process against a concern. This involved his representing through many lawyers who made his case weaker and made his opponents strong. Our patient remained quietly before the court and defended his case alone and won the process. Since then he felt himself unsettled. Trifles brought about extreme rage in him and this only when in his house. We have a very pale looking, haggard man before us, who complained of heart pains from least excitement, choking sensations, profuse perspiration, muscle spasms, tremors and a number of other ailments. As the first symptom we choose: “Ailments from indignation: Staph. Is in the highest grade, Coloc. and Nux v. (from Pierre SCHMIDT) in 2 grade; Ip and Plat. in smallest. Colcynthais is indicated more in physical ailments from indigestion, like abdominal colic and diarrhea; Staphisagria predominantly in mental consequences. As second symptom we choose: “violent anger”; Staph and Nux v. and other sin highest grade. As the third symptom: Diarrhoea from anger” and in the Repertory we find Staph. and Nux v. and other sin second grade. The Weihe point is sensitive in such a way that pressure from my finger brought about vomiting. Staphisgria XM made the patient feel changed, the Mozer point which indicate excitement of the heart chambers was gone. Report after 4 days: Feels himself significantly calmer, Now he can tolerate. Heart pain from every time he traveled in car, Sleep better. 14 days later : Sleeps peacefully. 2 months later : his wife reported : Excellent, Free from complaints. Sleeps peacefully. No heart pains. 4 months after the first dose I see the patient again. slight heart pain. I am astounded at his improved appearance. The deep pale appearance has totally gone away. The Mozer’s Coronary points are negative. He receives the second dose of Staphisagria XM. Report 2 months later: Free from ailments, even though in the meantime he had to accomplish a gigantic work. Staphisagria is one of those medicines indicated very often in these days. The employee who must swallow much, be it from his superior or his colleague and becoming ill therefrom, and the housewife who cannot vent her anger against the domestic servant lest she gives her quite notice, both need it. And Mr. Lycopodium, whose daughter enters into marriage with one who is not of her social standing and who feels that his pride is hurt, needs it (ailments after mortification: Staph.). We see now Lycopodium does not affect him any more, but again only after Staphisgria has rectified the hindrance. And the wife deceived by her husband also requires it. Here we do not take the rubric “Disappointed love”, which contains Staph. in second grade, but the next rubric “ailments from mortification” in highest grade. A valuable symptom of Staphisgria is” “angry at his own faults.” Nit-ac., Staph., and Sulph. have this, all in second grade. According to GALLAVARDIN Staphisagria is among the three remedies which cannot bear injustice (Ign., Staph., Nux v.). Patient 12 : The young 30 years old wife was again sent to me by the marriage counseller. She thought that she did not get the right husband and wanted to divorce him. Her youth was unpleasant, soon after marriage psychic depression developed due to which she was in a Nerve clinic 6 years ago. Since then it was tolerable until 21/2 years ago when she gave birth to her second child and all her ailment came on again. She feit herself in the same condition as she was before she was hospitalized, became excited over trifles, particularly with regard to her husband. She is not aware of her surroundings, sleepless, has no control of herself. Also headache, migraine, pain in the liver region and swollen ankle. After a three hours case recording and evaluation of the symptoms I could not find out the suitable medicine. I recalled the advice of Pierre SCHMIDT IN A SIMILAR CASE. The anamnesis indicated that her father had assaulted her in her youth. This is always combined with great fear even when the patient does not recall it. Here Opium is indicated (ailments from fright) We have: ailments from fright (Opium in highest grade) becoming afraid very easily (Opium in second grade) very sensitive to noise (Opium in second grade) cannot bear warm room (Opium in second grade) Opium is also a so called reactive medicine. We find it in the repertory section “Lack of reaction”. If KENT had 4 essential grades then this rubric would have Carbo Vegetabilis, Opium, Psorinum and Sulphur in 4th grade, perhaps also Nux vomica which will act because it antidotes the allopathic medicaments taken before. We may also expect a favourable action and it will bring into order the confusion in symptoms, so that it would be possible to choose a constitutional medicine easily. The patient received on 6-9-1961 Optium XM. On the next night itself she could sleep. Five weeks later report said: Since 10 days very well totally. since her youth, she has never felt so good, so easy. She can have refreshing sleep. Only the leucorrhoea which she has been having all along has become worse. On 9-10, that is 5 weeks after the first dose, Opium XM was again called for because – the sleep had become had after an excitement. On 26-11 Opium 50M On 26-12, tht is 3 months after the commencement of the treatment, I see the patient again. Since she suffered influenza the sleep was somewhat wanting. But in general, she felt excellent and calm despite temporary set back in sleep. “And how is your husband?” Oh, he is very well, he is nice. Before our treatment I have seen him as if through a spectacle, everything about him was crooked. Now I see him rightly. He is well in every respect.” A needle prick in Ling-sin point in the left side of the 24 point of the kidney-meridian, with a gold needle, set right the sleep again. The patient got Sulphur later. She is free from ailments. We must now terminate our expedition. My purpose was to convey certain hints which perhaps are not so well-known as they deserve to be. I personally am thankful to my teacher Pierre SCHMIDT. DEPRESSION IN A CASE OF GASTRITIS – PODOPHYLLUM WEGNER, A. ZKH, 32, 3/1988 A 41 year old female patient complained of cramping stomach pains during nights. It all began 3 years ago in spring with a Gastritis which recurred every year. The patient has always been suffering from a sensitive digestive system; as a child she used to easily get diarrhea from excitement. The cramps which awaken her occurred at three O’ clock mornings. It was better from pressure upon the abdomen, after eating and lying on abdomen. She had avoided rich foods since it could cause diarrhea. As a child she had peculiar desire for sour things. At 21 years her gall bladder which was full of stones was removed surgically because of colics. In 1979 she suffered Hepatitis with nausea, pressing sensation in the right upper abdomen, much diarrhea particularly in mornings with shining, almost white, stools and paroxysmal itching. She has not till date recouped after that. Three years ago she observed a peculiarly depressive disorder. Different anxieties came up. Daily routine work were affected badly because of this anxiety; anxiety about something which to her was very ominous to environment; anxiety about things which earlier had not anytime caused her restlessness. She characterized these states as: “as if the-world-was-coming-to-an-end state”, anxiety about life and mortal anxiety”. Gastroscopy was done and a clearly marked erosive gastritis was diagnosed and it was treated conservatively. since then it recurs annually as a gastro-intestinal disease which was contrary to the manner in which it began with a depressive mood but with colicky type pains explained above. The patient was observed to be having a vehement urge to talk which came up after an initial reservation. Repertorisation: In the repertories of GENTRY and KNERR the central symptom of the patient could be found: “Depression in gastritis”. “Depressed, in gastralgia: Abrot. (KNERR, p.38) “Depressed, in gastric affection: Pod. (KNERR, p. 38) “Depressed, in chronic gastritis: Mez (KNERR, p. 38) “Depression of spirits accompanying gastric affections: Pod. (GENTRY, Vol. I., p.30) From repertoristation certain symptoms with clear indication for Podophyllum were found (KENT): “Mind Loquacity, p.63: Podo. “Stomach, desires, sour, p.486: Podo. “Stomach, pain, cramping night, 3 a.m. p. 517: Podo. “Abdomen inflammation, Liver,p.553: Podo. “Abdomen , pain, liver, colic, gall-stones, p.568: Podo. Materia – Medica Comparison: good corresponding symptoms for Podophyllum were found: “Depression: Imagines he is going to die or be very ill, in gastric affection.” (GS. Vol. VIII, p. 504) “Delirium, loquacity during heat: afterwards forgetful of what has passed.” (GS. VOL. VIII, p. 504) “For years subject to diarrhea which would come on now and then after breakfast, with considerable pain in rectum…, an acute attack caused by bad news caused an early morning aggravation, as well as after eating; attack would also be induced by any depressing emotions or excitement of any kind…,” (GS. Vol. VIII, p. 507) “Jaundice: With gall-stones, pain from region of stomach to region of gall bladder, with excessive nausea; with hyperaemia of liver, fullness, sourness, and pain; alternate constipation and diarrhea, itching of skin…,” (GS. Vol. VIII, p.508) “Diarrhoea from indigestion after eating canned fruit…,” (GS. Vol. VIII, p. 510) “Awakened by violent pains in the stomach and bowels; the pain were of a griping, stitching character, and were relieved for a short time by pressure on the bowels, at 3 A.M. (EN, Vol. VIII, p.132, No.71) “Diarrhoea early in the morning which continues through the forenoon, followed by a natural stool, in the evening” (EN, Vol. VIII, p.133, No.107) Prescription: Podophyllum 0/6. After an aggravation on the second day after taking the medicine a sustained amelioration followed until she was completely free of the ailment, within two weeks, Two months later a relapse which came in a weaker form was promptly cured by Podophyllum 0/18. GS: Guiding symptoms by HERING. EN: Encyclopaedia of Pure Materia Medica, by T.F. ALLEN. CHRONIC FATIGUE, VIRUSES AND DEPRESSION R. E. KENDELL The Lancet, Vol.337: Jan.19, 1991 Patients often complain of persistent fatigue or generalized muscular weakness. A US survey found that chronic fatigue was “a major problem” for 24% of all adults attending primary care clinics1, and in a community survey in the UK 25% of women and 20% of men reported that they “always fee tired”.2 The causes of these symptoms are poorly understood and often generate strong differences of opinion both between doctors and between them and their patients. In some patients the weakness and fatigue developed after epidemics of an obscure illness known in the UK as benign myalgic encephalomyelitis and in the US as epidemic neuromyasthenia, but isolated cases are more common. The Myalgic Encephalomyelitis Association claims that there are 150.000 patients with myalgic encephalomyelitis (ME) in the UK;3 most of these are sporadic cases rather than part of well-defined epidemics, and BEHAN has suggested that the condition is as common as multiple sclerosis (about 3 cass per 100, 000.4) Whether these sporadic cases are caused by the same putative infection are important in the genesis of these states of persistent debility are unresolved issues. The terms “postviral fatigue syndrome” (PVFS), “postviral exhaustion”, ME and “chronic Epstein-Barr (EB) virus syndrome” embody an assumption that a viral infection is responsible for the patient’s weakness and fatigue. patients with a diagnosis of ME or PVFS have often been found to have a high frequency of unusually high viral antibody titres.4-6 However, as these patients have experienced a recent viral infection more commonly than the rest of the population almost by definition, firm conclusions cannot be drawn. In the US, despite reports of raised antibody titres to Epstein-Barr virus and human herpesvirus type 6, no evidence of persistent viral infection has been found7. In the UK, two groups have found persistent Coxsackie B virus infection in a proportion of patients with the PVFS. 8,9 Confirmation of these claims and the development of a reliable test for persistent Coxsackie infection would have a striking and salutary effect on the management of patients with chronic fatigue. At present, however, claims of abnormally prolonged “Jitter values” on single fibre electro-myography10 are un-confirmed and the histology, electrophysiology, and glycolytic enzymes of affected muscles appear to be normal. The development of excessive intracellular acidosis during exercise in a single patient examined by31 PNMR11 also seems to be a non-specific finding. 12 That most patients with PVS find mental exertion as exhausting as physical exertion also suggests tht a disorder of skeletal muscle is unlikely to account for all their symptoms. Although psychiatrists who see patients with these puzzling symptoms often diagnose a depressive illness, this or any other psychiatric diagnosis is frequently unacceptable to them, especially if it has previously been suggested tht they have ME. They are unshakeably convinced that their symptoms are due to organic illness and refuse antidepressive theory. It is not sufficiently widely appreciated, even by doctors, that affective illness characteristically cause a profound disturbance of energy. Manic patients have boundless energy and are overactive; depressed patients complain bitterly that they have no energy and are notably underactive, Indeed, the disturbance of energy and activity is almost as fundamental as the disturbance of mood. In the new (10th) revision of the International Classification of Disease the basic description of depressive episode begins with statement that “the subject suffers from lowering of mood, reduction of energy, and decrease in activity. Capacity for enjoyment, interest and concentration are impaired, and marked tiredness after even minimum effort is common.”13 Apart from the absence of any reference to previous viral infection, this description is almost indistinguishable from that of PVFS. Depressive illnesses are also twice as common in women as in men and are uncommon in children, two prominent and otherwise puzzling features of PVFS. Although ME and PVFS are new concepts, there is nothing novel about unexplained chronic fatigue and profound muscular weakness made worse by exercise. Both have been recognized for at least a century. The American neurologist George BEARD described what he called neurasthenia in 1867 and attributed it to exhausting of nerve cells through depletion of their stored nutriment.14 There are striking similarities between BEARD’s neurashthenia and ME: in symptoms, in the social setting in which it presented (predominantly middle classes), treatment (complete rest was advocated), and in presumed aetiology (a real illness, not a psychiatric disorder), 15 Neurashtenia initially encompassed much of what is now regarded as neurotic illness but by the early years of this century had come to mean unexplained exhaustion and fatigue. There was considerable debate about causation and the relative importance of physical and psychological factors and many therapies were tried, from absolute rest to psychoanalysis. By the 1940s there was general agreement that psychological influences were more important than overwork or endotoxins and, although the diagnosis is now rarely made, neurasthenia has survived as a discrete form of neurotic illness in the international classification even in new revision. When patients with chronic fatigue are assessed psychiatrically, between 50 and 80% are found to fulfil operational criteria for psychiatric disorder. 1-7,16,17 Most patients have major depression, others have anxiety or somatisation disorders, and many have an unusually high frequency of depressive episodes before the onset of fatigue. Only one study has failed to find a abnormally high prevalence of current and past psychiatric symptoms, but even here 22 of 48 patients (46%) met criteria for major depression at some stage in their illness.18 The relation between PVFS and the symptoms of both depressive illnesses and peripheral neuromuscular disease has been clarified by a prospective study. 17 47 patients with PVFS, 33 patients with fatiguing neuromuscular disorders – eg., myasthenia gravis and Guillain Barre syndrome, and 26 consecutive admissions with major depression were compared. Even when fatigue was excluded as a symptom, 72% of PVFS patients met operational criteria for psychiatric disorder, mainly major depression. Morever, the symptoms of the PVFS group and the depressive controls were almost identical. Fatigue brought about by mental and physical exertion was common in both groups, However, 18 of 21 PVS patients who met criteria for major depression were convinced that their illness had a physical basis. The neuromuscular disorder control patients described little mental fatigue, except in the presence of intercurrent psychiatric disorder, and had fewer somatic symptoms of other kinds. Patients may object to any suggestion that they have depression because such a diagnosis implies tht their symptoms are imaginary of “all in the mind”.19 Sadly, this assumption, with its crude distinction between real/organic illnesses and psychiatric disorders, seems to be shared by the ME Association and many doctors. Many of the symptoms of patients with ME or PVFS can only be understood as disturbances of cerebral functioning. Impaired concentration and memory, depression, insomnia, and irritability are not attributable to localized muscle disease, even if there is good evidence of muscle abnormalities. Evidence suggests that the whole range of depressive illness, not just endogenous depression, is familial and in part genetically transmitted. 20-21 Antidepressive drugs elevate mood in people who are depressed with little effect in normal people. These facts imply that there must be biological differences, qualitative, between people who are prone to depression and those who are not (trait differences) an between people who are currently depressed and those who are not (state differences). These differences must involve, or influence, cerebral function. Depression are commonly precipitated by stressful circumstances or life events, but the same is true of other disease such as myocardial infarction. Where then is the fundamental difference between depressive and ‘organic’ illnesses? Irrespective of the role of chronic viral infection. the symptoms of most patients with chronic fatigue states are real, pervasive, and often incapacitating. The only patients whose symptoms can legitimately be described as “all in the mind” are those whose disabilities are learnt behaviour and whose complaints have been moulded and potentiated by the advantages of the invalid role. 22 it is important to recognize that , in a society where ME is portrayed as a mysterious, rather glamourous, and disabling illness, people who have acquired this diagnosis may obtain attention and sympathy from friends and relatives, and perhaps also a justification for not fulfilling career ambitions or coping with the demands of everyday life. They may therefore lead less unhappy lives with their symptoms and their diagnosis than they could do otherwise. The statement that someone has a depressive illness is merely a statement about their symptoms. It has no causal implications, despite the fact that depression tht are secondary to a toxic state or metabolic abnormality – eg., Cushing’s disease or drug-induced depression, are usually classified separately. Furthermore, malaise and debility associated with infection may, by non-specific mechanisms shared with other stressors, help to predispose to subsequent infection by an effect on immune mechanisms and lymphocyte activity. 23 No fundamental distinction can therefore be drawn between depressive illness and other kinds of ‘real’ or ‘organic’ illness. Moreover, depressions have the great merit of being eminently treatable, unlike the chronic viral infections thought ot underline ME and the PVFS. Patients diagnosed as ME or PVFS are alsmot certainly heterogeneous. Some probably have chronic viral infections that are causally important, 8,9 others may have unrecognized disorders of their skeletal musculature. A substantial proportion, however, have depressive illnesses or other wellrecognised psychiatric disorders and in some there may be no clear distinction between these three categories. It is essential that a detailed psychiatric assessment is carried out on all such patients to ensure that a correct diagnosis is made and that appropriate treatment is given. The sudden appearance of symptoms in someone of normal previous personality does not exclude psychiatric disorder. Depressive illness commonly presents in this way. Terms like postinfective fatigue syndrome and myalgic encephalomyelitis, with their unproven assumption about aetiology, need to be replaced by neutral terms like chronic fatigue syndrome, unless there is hard evidence of persistent viral infection. It is also vital that in future all diagnostic terms are operationally defined. The Centres for Disease Control (CDC) in Atlanta have proposed an operational definition of chronic fatigue syndrome, partly to discourage clinicians from assuming, on inadequate evidence, that their patients have a “chronic EB virus syndrome” 24 The CDC definition has been made deliberately narrow to maximize the chances of those who fulfil its criteria having a chronic viral infection. Few patients with chronic fatigue meet these requirements.25 Broader definitions will therefore be needed if the majority of patients currently regarded as having ME or PVFS are to be covered. it is likely, though, that these definitions will include many patients who also fulfil criteria for major depression or other psychiatric disorders. REFERENCES 1. Kroenke K, Wood Dr, Mangelsdorff D, Meier NJ, Power JB. Chronic fatigue in primary care. JAMA 1988; 260; 929 -34. 2. Health Promotion Research Trust. The health and lifestyle survey. London. HPRT, 1987. 3. Annual Report. Myalgic Encephalomyelitis Association. Stanford le Hope, Essex: ME Association, 1989. 4. behan PO, Behan WMH, Bell EJ. The postviral fatigue syndrome – an analysis of the findings in 50 cses. J Infection 1985; 10: 21122. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15. 16. 17. 18. 19. 20. Straus Se, Tosato G, Armstrong G, et al. Persisting illness and fatigue in adults with evidence of Epstein – Barr virus infection. Ann Intern Med 1985; 102: 7 – 16. Calder BE, Warnock PJ, McCartney RA, Bell Ej. Coxsackie B viruses and the postviral syndrome: a prospective study in general practice. JR Coll Gen Pract 1987; 37: 11 – 14 Gold D, Bowden R Sixbey J, et al. Chronic fatigue: a prospective clinical and virological study. JAMA 1990; 264: 48 – 53 Yousef GE, Bell EJ, Mann GF, et al. Chronic enterovirus infection in patients with postviral fatigue syndrome. Lancet 1988; i. 146 -49 Archard LC, Bowks NE, Behan PO, Bell EJ, Doyle D. Postviral fatigue syndrome: persistence of enterovirus RNA in muscle and elevated creatine kinase. JR Soc Med 1988; 81: 326 – 29. Jamal GA, Hansen, Hansen S. Electrophysicological studies in the post viral fatigue syndrome. J Neurol Neurosurg Psychiatry 1985; 48: 961 – 64. Arnold DL, Bore PJ, Radda GK, Styles P, Taylor DJ. Excessive intracellular acidosis of skeletal muscle on exercise in a patient with a post-viral exhaustion fatigue syndrome. Lancet 1984; i: 1367 – 69. Yonge RP. Magnetic resonance muscle studies: implications for psychiatry: J R Soc Med 1988; 81: 322 – 25. World Health Organisation Division of Mental health. ICD – 10: 1989 Draft of Chapter V Mental and Behavioural Disorders. Geneva : WHO, 1989. Beard GM> Neurasthenia or nervous exhaustion, Boston Med Surg J 1969; 3: 217 – 20. Wessely S. Old wine in new bottles: neurasthenia and ‘ME’ Psychol Med 1990; 20: 35 – 53. Kruesi MJP, Dale J, Strauss SE. Psychiatric diagnoses in patients who have chronic fatigue syndrome. Br. J. Psychiatry 1989; 50: 53 – 56. Wessely S. Powell R. Fatigue syndromes: a comparison of patients with the chronic fatigue syndrome. Br. J. Psychiatry 1990; 156: 534 – 40. Hickie I, Lloyd A, Wakefield D, Parker G. The psychiatric status of patients with the chronic fatigue syndrome. Br. J. Psychiatry 1990; 156: 543 – 40. Church AJ. Myalgic encephalomyelitis: “An obscene cosmic joke”. Med J aust 1980; i: 307 – 09. Andersen NC, Scheftner A, Reich T, Hirschfed RMA, Endicott J, Keller MB. The validation of the concept of endogenous depression. Arch Gen Psychiatry 1986; 43: 246 – 51. 21. Kendler KS, Heath A, Martin NG, Eaves LJ. Symptoms of anxiety and depression in a volunteer twin population. Arch Gen Psychiatry 19876; 43: 213 – 221. 22. Kendell RE, Hysteria. In : Russell GFM, Hersov LA, eds. handbooks of psychiatry 4: The neuroses and personality disorders. Cambridge University Press, 1983; 232 – 46. 23. Schliefer SJ, Keller SE< Camerion M, Thornton JC, Stein M. Suppression of lymphocyte stimulation following bereavement. JAMA 1983; 250: 374 – 77. 24. Holmes GP, Kaplan JE, Gantz NM, et al. Chronic fatigue syndrome: a working case definition. Ann Intern Med 1988; 108: 387 – 89. 25. Manu P, Lane TJ, Matthews DA. The frequency of th chronic fatigue syndrome in patients with symptoms of persistent fatigue. Ann Intern Med 1988; 109: 554 - 556. Treatment for hypertension has undergone a remarkable transformation in the pst twenty years; prescribers now have a vast number of drugs from which to choose. However, although much time has been spent on defining classes of drug, none of the resulting classification is satisfactory. If official guidelines are followed, drug treatment should be offered to anyone with a diastolic pressure consistently greater than 100 mg Hg. 1 In the UK, for example, use of this criterion would net 10 – 15% of the adult population, and with the emphasis on detection and prevention, more patients than ever are goint to be found. The potential market for antihpertensive agents is enormous and pharmaceutical companies know it. One difficulty about treating high blood pressures is that most patients have no symptoms – therapy may cause side-effects in people who previously felt well. In trials of antihypertensive therapy, adverse reactions to drugs have resulted in withdrawal rates of 16 – 33% 2,3 Practitioners are often struck by the lower frequency of side-effects when an agent is used for antianginal rather than antihypertensive therapy, but the patient with angina knows when something is working. No antihypertensive drug is without sideeffects, although some are better tolerated than others, Moreover, with the availability of so many drugs, mere control of hypertension is not enough. Clinicians must not only strive to minimize drugspecific adverse events but also to assess the possible impact of treatment on a patient’s quality of life. CROOG and colleagues4 conducted one of the first large studies to assess quality of life; this work was supported by Squibb. Men with mild to moderate hypertension were recruited into a double-blind randomized trial for 6 months to determine the effects of captopril, methyldopa or propranolo on their quality of life as assessed by interviews throughout the study. Blood pressure control was similar with all three drugs, although some patients needed additional diuretics. Fewer patients withdrew from therapy with captopril becauses of adverse events. Patients receiving captropril scored better on measures of general well being and had fewer side-effects and better measures of life satisfaction than those receiving methyldopa. Captopril also scored better than propranolol in measures of well being. The subsequent marketing campaign alerted physicians to examine their prescribing practices but also initiated the controversy about the validity of what was measured. The difficulty is how to make a formal objective assessment of the subjective feelings and needs of an individual and obtain results with scientific credibility. Although captopril appeared best in the study by CROOG et al.4 the trial did not examine, for example, whether patients were troubled by cough, which is now known to affect DOING BETTER, 15% of those who take this FEELING drug. The tests were WORSE confined to patients’ The Lancet, Vol. subjective responses, 336, which may not be enough. Oct 27, 1990 JACHUCK et al5 asked physicians, patients taking antihypertensive drugs, and patients’ relatives or close companions about quality of life.5 In their overall assessment of each patient’s condition, 100% of physicians thought the patient was improved, 48 % of patients thought that they had improved, but 98% of relatives or companions believed that the patients’ quality of life was worse during therapy. To refine the objective estimate of quality of life, BULPITT and FLETCHER6 have now produced a questionnaire for use in short-term trials (less than 1 year) of antihypertensive treatment.6 The questionnaire covers symptomatic (physical) wellbeing, psychological wellbeing with the symptom rating test, 7 and perception of the effects of antihypertensive treatment on lifestyle. There are 46 questions, most of which require yes no responses. This approach must represent the most comprehensive attempt so far to obtain useful information about antihypertensive therapy by means of a standardized repeatable format. however, the feelings of relatives are not assessed. The test has been applied in three comparisons of drug tratments7-9 in symptomatic wellbeing and possibly increases depression, whereas nifedipine may adversely affect self-reported cognitive function. In another study, verapamil was compared with nifidipine with regard to effects on quality of life by use of this questionnaire. 10 There was a significant increase in reporting of side-effects with nifedipine, and measures of psychiatric morbidity tend to improve on verapamil and deteriorate on nifedipine. Only the change in cognitive function was significant between the drugs, being worse on nifiddipine. Notwithstanding these results, many patients will be satisfied with B-blockers or nifedipine, and the possibility of a modest improvement in cognitive function by a change to verapamil might be offset by the increased risk of constitpation. So, do assessment of quality of life help prescibers? BULPITT and FLETCHER’s questionnaire provides interesting information about important aspects of drug treatment and may highlight previously unsuspected adverse effects. It will prove a standardized protocol for future studies and may reveal small differences between drugs. The relevance of such trial assessments to the individual needs of patients or prescribing practices is uncertain. They will not replace the close personal monitoring that all patients should receive when they are expected to embark on a treatment regimen for life. REFERENCES 1. Swales JD, Ramsay LE, Coope JR, et al. Treating mild hypertension Report of the British Hypertension Soceity Working Party, Br. Med. J 1989; 298: 694 – 98. 2. MRC Working Party on Mild to Moderate Hypertension. Adverse reactions to bendrofluazide and propranolol for the treatment of mild hypertension. Lancet 1981; ii: 539 – 43. 3. Curb JD, Borhani NO, Blaszkowski TP, Zimbaldi N, Fotiu S, Williams W. Long-term surveillance for adverse effects of antihypertensive drugs. JAMA 1985; 253; 3263 – 68. 4. Croog SH, Levine S, Testa M. et al. The effects of antihpertensive therapy on the quality of life N. Engl J Med 1986; 314; 1657 – 64. 5. Jachuck SJ, Brierley H. Jachuck S, Willcox PM. The effect of hypotensiv drugs on the quality of life. J. Coll Gen Pract 1982; 32: 103 – 05. 6. Bulpitt CJ, Fletcher AE. The measurement of quality of life in hypertensive patients: a practical approach. Br. J. Clin Pharmacol 1990; 30; 353 – 64. 7. Fletcher AE, Chester PC, Hawkins CMA Latham An, Pike La, Bulpitt CJ. The effects of varapamil and propranolol on quality of life in hypertension. J. Hwm Hypertens 1989; 3: 125 – 30. 8. Fletcher AE, Bulpitt CJ, Quality of life during antihypertensive treatment: results from a randomized double-blind trial of pinacidil and nifedipine. J. Hypertens 1989; 7 (suppl 6): 364 (abstr). 9. Fletcher AE, Bulpitt CJ, Hawkins CM, et al. Quality of life on anti-hypertensive therapy: a randomized double – blind controlled trial of captopril and atenolol. J. Hypertens 1990; 8: 463 – 66. 10. Palmer A, Fletcher A, Hamilton G, Muriss S, Bulpitt C.A comparison of verapamil and nifedipine on quality of life Br. J. Clin Parmacol 1990; 30: 365 – 70. BOOK SHELF: TIPS BY MASTERS OF HOMEOPATHY by Dr. S.R. WADIA, MBBS, F.F. Hom. (Lond.), by Jain Publishers (P) Ltd., Post Box 5775, New Delhi110 055, p.p.64, Rs 10/Dr. WADIA has, over the years collected, some ‘gems from various sources. These have now been compiled in alphabetical order and presented to the profession. There are many ‘tips’ like: “Calotropis gigantean – has depression as the characteristic mental symptom. “Drosera – has shivering at rest; not while moving. “Vipera - effective for chronic nose bleed – even when the condition is life long. Source has been mentioned for every ‘tip’. There is no doubt that this compilation will be most welcome to the practitioners. Printing, paper etc. good. Warmly recommended. K.S. SRINIVASAN. PRESS NOTE ALL INDIA HOMOEOPATHIC SEMINAR will be organized at AHMEDABAD (Gujarat) on 8th, 9th, 10th November 1991 by the Ahmedabad Unit of H.M.A.I. TOPIC : HEALTHY CHILD – HEALTHY NATION Lectures-discussions in different areas of Child Health are planned on basis of clinical experiences of the Homoeopathy attending the seminar from all over the country. Articles/Papers in this subject are invited, to reach the Seminar office by 30.9.1991. A NATIONAL HOMOEOPATHIC QUIZ is also planned on the occasion, where teams of each State are expected to participate. Delegate Fee : Rs. 350/- RC Member Fee : Rs. 500/Student Delegate : Rs. 300/- Accompanying person Rs. 350/Fees to reach the office by 30.8.1991. Seminar Office: All India Homoeopathic Seminar 8, Shalimar Complex, Near Mahalaxmi, Five Road Junction, Paladi, Ahamedabad – 380 007.