Pathophysiology
Pathophysiology is a study of causes, mechanisms, course and consequences of the disease. The
study gives an explanation of organism disfunction mechanisms as a reason or consequence of
various diseases on molecular, cellular and systemic level. This knowledge should create basis for
good understanding the pathomechanisms of disturbed life processes in different diseases and
indicate proper laboratory tests for its affirmation.
Before starting tutorials the students should revise the anatomy, physiology, histology and
biochemistry.
Lectures:
prof. dr hab. Danuta Rość
prof. dr hab. med. Ewa Żekanowska
Tutorials:
dr n. med. Barbara Ruszkowska
dr n. med. Justyna Kwapisz
lek. med. Beata Lisewska
dr n. med. Artur Słomka
Contact: dr Justyna Kwapisz, justyna.kwapisz@gmail.com
Syllabus
I.Name of the unit offering the course: Chair of Pathophysiology
II.Haed of the unit: Rość Danuta MD, PhD, professor
III.Faculty of Medicine, Medical Program, year: II, 75 hours in second semester
IV.Cours coordinator: Justyna Kwapisz MD, justyna.kwapisz@gmail.com
V.Form of classes (lecture, tutorials, seminars): Lectures, tutorials
VI. Form of crediting: 6 points of ECTS
VII. Number of hours: 30 lectures, 45 tutorials
VIII. Topic of lectures/tutorials/ seminars
Lectures (2 academic hours)
1/ Pathophysiology. Etiology and pathology of the disease. Pathogenesis hormones
imbalance.
2/ Pathogenesis of neoplasia. Pathogenesis of inflammation. Cell and plasma-derived
mediators of inflammation.
3/ Disorders of carbohydrate metabolism. Pathophysiology of obesity. Polymetabolic
syndrome.
4/ Disorders of calcium and phosphate metabolism. Hematopoiesis.
5/ Pathogenic mechanisms of leukemias. Test. (Pathophysiology of endocrine system.)
6/ Pathophysiology of anemias. Pathophysiology of polyglobulia.
7/ Lymphoproliferative disorders. Pathogenic mechanisms of haemostatic disorders.
8/Fibrinolysis. Kininogenesis. Pathogenic mechanisms of thrombosis.
9/ Coagulopathies. Disseminated intravascular coagulation.
10/ Pathogenesis of atherosclerosis. Test. (Pathophysiology of hematopoiesis and
haemostasis.)
11/ Ischaemic heart disease. Pathophysiology of hypertension.
12/ Pathogenesis of circulatory failure. Heart failure.Peripheral circulatory failure – shock.
Classification of shock. Compensatory mechanisms.
13/ Pathogenic mechanisms of renal failure. Test. (Pathophysiology of cardiovascular
system.)
14/ Pathophysiology of liver failure. Plasma proteins in various diseases.
15/ Water-electrolyte imbalance. Test.(Pathophysiology of renal and gastrointestinal
systems.)
Tutorials (3 academic hours)
1.
Disorders of the pituitary and thyroid gland.
2.
Disorders of the adrenal glands. Disorders of the reproductive system.
3.
Disorders of the parathyroid glands. Osteoporosis.
4.
Pathogenesis of diabetes mellitus.
5.
Disorders of erythropoietic system.
6.
Disorders of leucocytic system.
7.
Pathology of coagulation process. Haemorrhagic diathesis. Thrombosis.
8.
Pathological changes in ECG. Heart rhythm disorders.
9.
Pathophysiology of the respiratory system.
10.
Valvular heart disease.
11.
Myocardial infarction. Heart failure.
12.
Pathology of the liver. Pathology of the digestive system.
13.
Acid-base disorders.
14.
Pathogenesis of acute renal failure and chronic kidney disease. Signs and symptoms of
renal failure.
15.
Patophysiology of aging. Environmentally induced diseases.
IX. Booklist (basic/additional):
a/ „Pathophysiology of Disease” An Introduction to Clinical Medicine, S.J. McPhee, W. F. Ganong.
International Edition 2006, fifth edition.
b/ “Pathophysiology” Clinical concepts of disease processes. S. A. Price, L. M. Wilson. Mosby, Inc.
2003.
c/ Prawon D., Singer CRJ, Baglin T., Lelleyman. Oxford handbook of Clinical Haematology. Oxford
University 2004.
d/ Robbins & Cotran: Atlas of Pathology & Robbins Basic Patholog. W. B. Saunders Company 2006
e/ Sylvia A. Price, Lorraine M. Wilson: Pathophysiology, clinical of disease process. Mosby, sixth
edotion, 2003
f/http://www.Itcombudsman.org/uploads/TheAgingProcess1.pdf
g/http://www.angelfire.com/ns/southeasternnurse/TheoriesofAgingC3
h/ http://library.med.utah.edu/WebPath/LIVEHTML/LIVERIDX.html
Rules and regulations
1.
Time table for Pathophysiology course includes 15 2-hour lectures and 15 3-hour
tutorials in the second semester.
2. Any information regarding the time table and current matters is shown on the
noticeboard.
3. Students are expected to prepare for each tutorial taking account of the information on
the noticeboard. Participation in tutorials is compulsory. Every absence must be accounted
for and cleared by the tutor. The missed tutorial must be rescheduled with the tutor to
occur within the current period of tutorials.
4. After each period of tutorials there is a test and it takes place during the lecture no. 5th,
10th, 13th, 15th. Test contains 30 questions. Test grading system: fail (2.0) <16 points;
sufficient (3.0): 16 - 19 points; sufficient plus: 20 - 22 points; good (4.0): 23 - 25 points;
good plus (4.5): 26 - 28 points; very good (5.0): 29 - 30 points.
5. In the event of failing the test a student has one chance to retake it.
6. Pathophysiology course ends with an exam which covers all the material in the
tutorials and lectures. Entrance to the final exam is only granted after all the tests have
been passed. Continuous assessment and grades obtained in tutorials constitute part of the
final grades in the tests.
7. Exam contains 40 questions. Exam grading system: fail (2.0) <21 points; sufficient
(3.0): 21 - 26 points; sufficient plus: 27 - 31 points; good (4.0): 32 - 35 points; good plus
(4.5): 36 - 38 points; very good (5.0): 39 - 40 points.
8. The Head of the Chair of Pathophysiology prof. Danuta Rość is available for
consultations with students every Thursday ……………………
9. Course coordinator dr. Justyna Kwapisz is available for consultations with students
every ………………………………….
10. Students must wear white lab coats during the practical element of the tutorials.
11. Absence on medical grounds must be certified and cleared with the tutor with the 7
days of the absence.
12. Student must prepare one presentation (10 minutes long) during the semester. The
presentation will be assessed with grades 0, 1 or 2 and will contribute to the final grade of
the test. Student failing to prepare for a given presentations will receive a grade of minus
one.
13. At all time students are expected to behave in a manner approached to an academic
setting. Students mustn’t use Internet during the tutorials.