Pathophysiology
Pathophysiology is a study of causes, mechanisms, course and consequences of the disease.
The study gives an explanation of organism disfunction mechanisms as a reason or
consequence of various diseases on molecular, cellular and systemic level. The knowledge
should create basis for good understanding the pathomechanisms of disturbed life processes
in different diseases and indicate proper laboratory tests for its affirmation.
Before starting tutorials the students should revise the anatomy, physiology, histology and
biochemistry.
Lecturers:
1. Prof. Danuta Rość
2. Prof. Ewa Żekanowska
Teachers:
1.
2.
3.
4.
dr JustynaKwapisz
dr Barbara Ruszkowska
dr ArturSłomka
lek. med. BeataLisewska
Contact: dr Justyna Kwapisz justyna.kwapisz@gmail.com
Syllabus
I. Name of the unit offering the course: Chair of Pathophysiology
II. Head of the unit: Rość Danuta MD, PhD, professor
III. Faculty of Medicine, Medical Program, year: II, 75 hours in second semester
IV. Course coordinator: JustynaKwapiszjustyna.kwapisz@gmail.com
V. Form of classes (lecture, tutorials, seminars): Lectures, tutorials
VI. Form of crediting: 6 points of ECTS
VII. Number of hours: 30 lectures, 45 tutorials
VIII. Topic of lectures/tutorials/seminars
Lectures (2 academic hours)
1/ Pathophysiology. Etiology and pathology of the disease. Pathogenesis of hormones
imbalance.
2/ Pathogenesis of neoplasia. Pathogenesis of inflammation. Cell and plasma-derived
mediators of inflammation.
3/ Disorders of carbohydrate metabolism. Pathophysiology of obesity. Polymetabolic
syndrome.
4/ Disorders of calcium and phosphate metabolism.Hematopoiesis.
5/ Pathogenic mechanisms of leukemias. Test (Pathophysiology of endocrine system).
6/ Pathophysiology of anemias.Pathophysiology of polyglobulia.
7/ Lymphoproliferative disorders.Pathogenic mechanisms of haemostatic disorders.
8/Fibrinolysis. Kininogenesis.Pathogenic mechanisms of thrombosis.
9/ Coagulopathies. Disseminated intravascular coagulation.
10/ Pathogenesis of atherosclerosis. Test (Pathophysiology of cardiovascular system).
11/ Ischaemic heart disease. Pathophysiology of hypertension.
12/ Pathogenesis of circulatory failure. Heart failure.Peripheral circulatory failure – shock.
Classification of shock. Compensatory mechanisms.
13/ Pathogenic mechanisms of renal failure. Test (Pathophysiology of hematopoiesis and
haemostasis).
14/ Pathophysiology of liver failure. Plasma proteins in various diseases.
15/ Water-electrolyte imbalance. Test (Pathophysiology of renal and gastrointestinal
systems).
Tutorials (3 academic hours)
1.
Disorders of the pituitary and thyroid gland.
2.
Disorders of the adrenal glands. Disorders of the reproductive system.
3.
Disorders of the parathyroid glands. Osteoporosis.
4.
Pathogenesis of diabetes mellitus.
5.
Disorders of erythropoietic system.
6.
Disorders of leucocytic system.
7.
Pathology of coagulation process. Haemorrhagic diathesis. Thrombosis.
8.
Pathological changes in ECG. Heart rhythm disorders.
9.
Pathophysiology of the respiratory system.
10.
Valvular heart disease.
11.
Myocardial infarction. Heart failure.
12.
Pathology of the liver. Pathology of the digestive system.
13.
Acid-base disorders.
14.
Pathogenesis of acute renal failure and chronic kidney disease.Signs and symptoms of
renal failure.
15.
Pathophysiology of aging. Environmentally induced disease.
IX. Booklist (basic/additional):
a/ „Pathophysiology of Disease” An Introduction to Clinical Medicine, S.J. McPhee, W. F.
Ganong. International Edition 2006, fifth edition.
b/ “Pathophysiology” Clinical concepts of disease processes. S. A. Price, L. M. Wilson. Mosby,
Inc. 2003.
c/ Prawon D., Singer CRJ, Baglin T., Lelleyman. Oxford handbook of Clinical Haematology.
Oxford University 2004.
d/ Robbins &Cotran: Atlas of Pathology & Robbins Basic Patholog. W. B. Saunders Company
2006
e/ Sylvia A. Price, Lorraine M. Wilson: Pathophysiology, clinical of disease process. Mosby,
sixth edition, 2003
f/http://www.Itcombudsman.org/uploads/TheAgingProcess1.pdf
g/http://www.angelfire.com/ns/southeasternnurse/TheoriesofAgingC3
h/ http://library.med.utah.edu/WebPath/LIVEHTML/LIVERIDX.html
1. Disorders of the pituitary and thyroid gland. – dr JustynaKwapisz
2. Disorders of the adrenal glands. Disorders of the reproductive system. – dr
JustynaKwapisz
3. Disorders of the parathyroid glands. Osteoporosis. –dr JustynaKwapisz
4. Pathogenesis of diabetes mellitus. –dr JustynaKwapisz
5. Disorders of erythropoietic system. – dr ArturSłomka
6. Disorders of leucocytic system.– dr ArturSłomka
7. Pathology of coagulation process. Haemorrhagic diathesis. Thrombosis. – dr
ArturSłomka
8. Pathological changes in ECG. Heart rhythm disorders. –lek. med. Beata Lisewska
9. Pathophysiology of the respiratory system. –lek. med. Beata Lisewska
10. Valvular heart disease. –lek. med. Beata Lisewska
11. Heart failure. Myocardial infarction. – lek. med. Beata Lisewska
12. Pathology of the liver. Pathology of the digestive system. – dr Barbara Ruszkowska
13. Acid-base disorders. – dr Barbara Ruszkowska
14. Pathogenesis of acute renal failure and chronic kidney disease. Signs and symptoms of
renal failure.– dr Barbara Ruszkowska
15. Pathophysiology of aging. Environmentally induced disease. – dr Barbara Ruszkowska
Rules and regulations
1. Timetable for Pathophysiology course includes 30 hours of lectures and 45 hours of
tutorials in second semester.
2. Any information regarding the timetable and current matters is shown on the
noticeboard.
3. Students are expected to prepare for each tutorial taking account of the information on
the noticeboard. Participation in tutorials is compulsory. Every absence must be accounted
for and cleared by the tutor. The missed tutorial must be rescheduled with the tutor to occur
within the current period of tutorials.
4. After each period of tutorials there is a test (tests will be taken during the lectures nr 5,
10, 13 and 15).
5. In the event of failing the test a student has one chance to retake it.
6. Pathophysiology course ends with an exam which covers all the material in the tutorials
and lectures. Entrance to the final exam is only granted after all the tests have been passed.
Continous assessment and grades obtained in tutorials constitute part of the final grades in
the tests. Student obtaining an average grade ≥4.5 in the final four tests will be exempt for
taking the final exam.
7. The Head of the Chair of Pathophysiology prof. DanutaRość is available for consultations
with students every Thursday 14.00 – 15.00.
8. Course coordinator dr. JustynaKwapisz is available for consultations with students
every………………………
9. Students must wear white lab coats during the practical element of the tutorials.
10. Absence on medical ground must be certified and cleared with the tutor with the 7 days
of the absence.
11. Student must prepare one presentation (10 minutes long) during the semester. The
presentation will be assessed with grades 0,1 or 2 and will contribute to the final grade of
the test. Student failing to prepare for a given presentation will receive a grade of minus
one.
12. At all time students are expected to behave in a manner approached to an academic
setting.Students mustn’t use Internet during the tutorials.