Biochemistry 3G03
Biochemistry of Macromolecules
Term I (2014-2015)
Course Outline
Instructor:
Dr. Daniel Yang. Office: HSC-4H25a, yang@mcmaster.ca
Teaching Assistants:
Sanchia Miller
Mobolaji Adelou
sanchiamiller@gmail.com
adeolum@mcmaster.ca
Introduction: Chemical and conformational properties of proteins and relationships to their function including
regulation of enzyme activity. Chemical and physical structure of DNA and RNA relevant to biological function.
Evaluation: It will be based on six tests (all multiple choices). The final grade will be calculated with the sixth
test plus the best 4 out of the first five tests. No make-up tests will be offered. If you miss a test (with or without
filing MSAF), the test will receive a grade of ZERO and will not be used towards calculating the final grade. No
deferred examination will be given due to the lack of a final examination. Students are responsible for materials
covered in the textbook and lectures. Percentage grade will be converted to a final letter grade (see Table below).
%
Letter
%
Letter
%
Letter
%
Letter
%
Letter
100-90
A+
79 - 77
B+
69 – 67
C+
59-57
D+
49-0
F
89 – 85
A
76 - 73
B
66 – 63
C
56-53
D
84 – 80
A72 - 70
B60-62
C52-50
DAll percentage grades within 0.5% of the next letter grade will be reviewed.
You have one week after a test has been completed and the results released to contact the course instructor, to
report an issue, ie. incorrect addition. Please make sure to take a good look at your test results once they are
released.
Questions: Students are encouraged to ask questions in class and use Learnlink for discussion.
Textbook: Essential Biochemistry, 3rd edition. C.W.Pratt and K. Cornely. Wiley & Sons Inc. 2014.
Academic ethics: Students are asked to reread two documents provided on registration, the Senate Statement on
Academic Ethics and the Senate Resolutions on Academic Dishonesty. Students should be sure that they
understand the expectations the University has of its scholars, and the possible consequences when these
expectations are not met.
Academic dishonesty consists of misrepresentation by deception or by other fraudulent means and can result in
serious consequences, e.g. the grade of zero on an assignment, loss of credit with a notation on the transcript
(notation reads: “Grade of F assigned for academic dishonesty”), and/or suspension or expulsion from the
university. It is your responsibility to understand what constitutes academic dishonesty. For information on the
various kinds of academic dishonesty please refer to the Academic Integrity Policy, specifically Appendix 3,
located at: http://www.mcmaster.ca/univsec/policy/AcademicIntegrity.pdf
Additional notes: The instructor and university reserve the right to modify elements of the course during the
term. The university may change the dates and deadlines for any or all courses in extreme circumstances. If
either type of modification becomes necessary, reasonable notice and communication with the students will be
given with explanation and the opportunity to comment on changes. It is the responsibility of the student to
check their McMaster email and course websites weekly during the term and to note any changes.
Schedule of Lectures, Office hours & Tests.
Lectures: Mon, Wed, 8:30-9:20am; Fri, 10:30-11:20am; CNH/104
Office hour: Wed (9:30-10:30 am); HSC-4H25a
Lecture
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
Topics-Remarks
Chapter
Organization
Chemical Basis of Life
1
Chemical Basis of Life
1
Aqueous Chemistry
2
Aqueous Chemistry
2
Test 1 (Chapters 1 & 2)
1-2
From Genes to Proteins
3
From Genes to Proteins
3
From Genes to Proteins
3
Protein Structure
4
Protein Structure – PYMOL
4
Test 2 (+ Chapters 3)
1-3
Protein Structure
4
Protein Function
5
Protein Function
5
Protein Function
5
No Class (Thanksgiving)
Test 3 (+Chapters 4 & 5)
1-5
How Enzymes Work
6
How Enzymes Work
6
How Enzymes Work
6
Enzyme Kinetics and Inhibition
7
Enzyme Kinetics and Inhibition
7
Test 4 (+Chapters 6)
1-6
No Class (Mid-term recess)
Enzyme Kinetics and Inhibition
7
DNA Replication and Repair
20
DNA Replication and Repair
20
DNA Replication and Repair
20
Test 5 (+Chapters 7)
1-7
Transcription and RNA
21
Transcription and RNA
21
Transcription and RNA
21
Protein Synthesis
22
Protein Synthesis
22
Test 6 (+Chapters 20 & 21)
1-7; 20,21
Protein Synthesis
22
No Class
22
No Class
NO Final Exam
Note: Tutorials infos will be posted on LEARNLINK
Date
Sept-5th
Sept-8th
Sept-10th
Sept-12th
Sept-15th
Sept-17th
Sept-19th
Sept-22rd
Sept-24th
Sept-26th
Sept-29th
Oct-1st
Oct-3rd
Oct-6th
Oct-8th
Oct-10th
Oct-13th
Oct-15th
Oct-17th
Oct-20th
Oct-22rd
Oct-24th
Oct-27th
Oct-29th
Oct-31st
Nov-3rd
Nov-5th
Nov-7th
Nov-10th
Nov-12th
Nov-14th
Nov-17th
Nov-19th
Nov-21st
Nov-24th
Nov-26th
Nov-28th
Dec-1st
Dec-3rd
Learnlink:
Courses
BIOCHEM Program
Biochem3G03
To access LearnLink, please go to:
https://www.learnlink.mcmaster.ca
download and install LEARNLINK, or use browser access
To login to your account use the following default information:
- User ID: Firstname.Lastname
- Password: Your 7-digit student number
(In cases with hyphenated names, please include the hyphen.)
(Neither user ID nor password are case-sensitive.)
Any students who registered late in the summer, or have not yet
completed their university registration, will not be on the class list and will not have access to LearnLink. If you have
problem in in access LearnLink please send an email to
admin@learnlink.mcmaster.ca.