Biochemistry 3G03: Biochemistry of Macromolecules Contact Information Instructor Dr. Daniel Yang yang@mcmaster.ca Ext. 22455 Office: HSC 4H25a Office Hours: Thursday 1:30 pm -­‐ 2:20 pm Teaching Assistants Laura DiGiovanni digiovlf@mcmaster.ca Leticia Gonzales gonzalla@mcmaster.ca Course Website Course information will be posted on learnlink. Learnlink: Courses BIOCHEM Program Biochem3G03 To access LearnLink, please go to: https://www.learnlink.mcmaster.ca download and install LEARNLINK, or use browser access To login to your account use the following default information: -­‐ User ID: Firstname.Lastname -­‐ Password: Your 7-­‐digit student number (In cases with hyphenated names, please include the hyphen.) (Neither user ID nor password are case-­‐sensitive.) Any students who registered late in the summer, or have not yet completed their university registration, will not be on the class list and will not have access to LearnLink. If you have problem in in access LearnLink please send an email to help@learnlink.mcmaster.ca
1 Course Information Course Description Chemical and conformational properties of proteins and relationships to their function including
regulation of enzyme activity. Chemical and physical structure of DNA and RNA relevant to biological
function.
Monday, Thursday 12:30 -­‐ 1:20 pm; Tuesday 1:30 -­‐ 2:20 pm; Term 1 TSH/120 Course Objectives By the end of this course the student should be able to: • accurately describe the chemical and conformational properties of proteins • explain how enzyme works and how its structure is related to its function • describe the structures of DNA and RNA • accurately describe the various factors involved in the execution and regulation of replication, transcription and translation Materials and Fees Textbook Essential Biochemistry, 3rd edition. C.W.Pratt and K. Cornely. Wiley & Sons Inc. 2014. (required) This book is available at the Campus Store. Calculator Only the McMaster standard calculator (Casio fx-­‐991MS) will be allowed during all tests and exams. It is available at the Campus Store Course Requirements Evaluation: It will be based on six tests (all multiple choices). The final grade will be calculated with the
sixth test plus the best 4 out of the first five tests. No make-up tests except the 6th test will be offered. If
you miss a test (with or without filing MSAF), the test will receive a grade of ZERO and will not be used
towards calculating the final grade. Students are responsible for materials covered in the textbook and
lectures. Percentage grade will be converted to a final letter grade (see Table below).
2 % Letter % Letter % Letter % 100-­‐90 A+ 79 -­‐ 77 B+ 69 – 67 C+ 59-­‐57 89 – 85 A 76 -­‐ 73 B 66 – 63 C 56-­‐53 84 – 80 A-­‐ 72 -­‐ 70 B-­‐ 60-­‐62 C-­‐ 52-­‐50 All percentage grades within 0.5% of the next letter grade will be reviewed. Letter D+ D D-­‐ % 49-­‐0 Letter F You have one week after a test has been completed and the results released to contact the course instructor, to report an issue, ie. incorrect addition. Please make sure to take a good look at your test results once they are released. Course Schedule Lecture Date 1 Sept-­‐8 Sept-­‐10 2 Sept-­‐14 3 Sept-­‐15 4 Sept-­‐17 5 Sept-­‐21 6 Sept-­‐22 7 Sept-­‐24 8 Sept-­‐28 9 Sept-­‐29 10 Oct-­‐1 11 Oct-­‐5 12 Oct-­‐6 13 Oct-­‐8 Oct-­‐12-­‐Oct-­‐15 14 Oct-­‐19 15 Oct-­‐20 16 Oct-­‐22 17 Oct-­‐26 18 Oct-­‐27 19 Oct-­‐29 20 Nov-­‐2 21 Nov-­‐3 22 Nov-­‐5 23 Nov-­‐9 24 Nov-­‐10 25 Nov-­‐12 26 Nov-­‐16 27 Nov-­‐17 Topics-­‐Remarks Organization No Class Chemical Basis of Life Chemical Basis of Life Aqueous Chemistry Aqueous Chemistry Test 1 From Genes to Proteins From Genes to Proteins From Genes to Proteins Protein Structure Protein Structure Test 2 Protein Function Recess Protein Function Test 3 Protein Function How Enzymes Work How Enzymes Work How Enzymes Work Enzyme Kinetics and Inhibition Test 4 Enzyme Kinetics and Inhibition Enzyme Kinetics and Inhibition DNA Replication and Repair DNA Replication and Repair DNA Replication and Repair Test 5 3 Chapter Ch 1 Ch 1 Ch 2 Ch 2 1,2 Ch 3 Ch 3 Ch 3 Ch 4 Ch 4 Ch 1-­‐3 Ch 5 Ch 5 Ch 1-­‐4 Ch 5 Ch 6 Ch 6 Ch 6 Ch 7 Ch 1-­‐6 Ch 7 Ch 7 Ch 20 Ch 20 Ch 20 Ch 1-­‐ 20 28 Nov-­‐19 Transcription and RNA Ch 21 29 Nov-­‐23 Transcription and RNA Ch 21 30 Nov-­‐24 Transcription and RNA Ch 21 31 Nov-­‐26 Protein Synthesis Ch 22 32 Nov-­‐30 Protein Synthesis Ch 22 33 Dec-­‐1 Test 6 Ch 1-­‐ 22 34 Dec-­‐3 Protein Synthesis Ch 22 Dec-­‐7 No Class Dec-­‐8 No Class Final Exam This course has no final exam. Missed Work If you are absent from the university for a minor medical reason, lasting fewer than 5 days, you may report your absence, one per term, without documentation, using the McMaster Student Absence Form (http://www.mcmaster.ca/msaf/). Absences for a long duration or for other reasons must be reported to the Associate Dean of Science office, with documentation, and relief may not necessarily be granted. After filling out the MSAF you must immediately contact your course instructor (normally within 2 working days) by email to learn what relief may be granted for the work you have missed and relevant details for submission or location of make-­‐up test. Please note that the MSAF may not be used for term work worth 25% or more, nor can it be used for the final exam. University Policies Academic Integrity You are expected to exhibit honesty and use ethical behaviour in all aspects of the learning process. Academic credentials you ear are rooted in principles of honesty and academic integrity. Academic dishonesty is to knowingly act or fail to act in a way that results or could result in unearned academic credit or advantage. This behaviour can result in serious consequences, e.g. the grade of zero on an assignment, loss of credit with a notation on the transcript (notation reads: “Grade of F assigned for academic dishonesty”), and/or suspension or expulsion from the university. It is your responsibility to understand what constitutes academic dishonesty. For information on the various types of academic dishonesty please refer to the Academic Integrity Policy, located at www.mcmaster.ca/academicintegrity. The following illustrates only three forms of academic dishonesty: 1. Plagiarism, e.g. the submission of work that is not one’s own or for which other credit had been obtained. 2. Improper collaboration in group work. 3. Copying or using unauthorized aids in tests and examinations. Course Online Content In this course we will be using (email, Learn Link). Students should be aware that, when they access the electronic components of this course, private information such as first and last names, user names for the McMaster email accounts, and program affiliation may become apparent to all other students in the same course. The available information is dependent on the technology used. Continuation in this 4 course will be deemed consent to this disclosure. If you have questions or concerns about such disclosure, please discuss this with the course instructor. Student Accessibility Students who require academic accommodation must contact Student Accessibility Services (SAS) to make arrangements with a Program Coordinator. Academic accommodations must be arranged for each term of study. Student Accessibility Services can be contacted by phone 905-­‐525-­‐9140 ext. 28652 or e-­‐
mail sas@mcmaster.ca. For further information, consult McMaster University’s Policy for Academic Accommodation of Students with Disabilities. Changes to the Course Outline The instructor and University reserve the right to modify elements of the course during the term. The University may change the dates and deadlines for any or all courses in extreme circumstances. If either type of modification becomes necessary, reasonable notice and communication with the students will be given with explanation and opportunity to comment on changes. It is the responsibility of students to check their McMaster email accounts and course websites weekly during the term and to note any changes. 5