Field Neurosciences Institute Winter 2012 Field Notes Field of Hope - Steps Ahead Spring Gala and 50 Year Celebrations In Memory - Jeff Coupie Neuroscience Nursing Events FNI News Image shows beta amyloid plaques (in pink) from the brain of a mouse carrying human Alzheimer’s disease genes. FNI researchers are searching for treatments that would reduce these plaques, which are hallmarks of Alzheimer’s disease pathology. 1 E. Malcolm Field, M.D., D. Sc. FNI Medical Director Gary L. Dunbar, Ph.D. Executive Director, FNI ‘Thanks Given’ to Our FNI Family At the commencement of our holiday season, it is an opportune time to give thanks to our FNI family--all of the staff, board members, volunteers, and donors—who, collectively, make FNI a wonderful place to work and a valuable asset to our community. Although this past year has had its share of trials and tribulations, our FNI family has held strong and has continued to make significant advances in our mission to help prevent, care, and cure neurological disorders. Our ThinkFirst program continues to be a national model—providing educational programs to schools around the mid-Michigan area—and providing a leadership role at the state and national level. Our support groups for MS and spinal cord injury provide important information and a welcomed source of help to those affected and for their families and caretakers. Our educational programs, including our weekly Grand Rounds, continue to provide area physicians and healthcare providers with new insights into basic research and clinical applications that can benefit patients. Our efforts to partner with organizations, such as the Alzheimer’s Association and the Huntington Disease Society of America, has provided renewed hope for the collective research efforts at FNI and beyond. Our efforts to help raise funds for the Stealth System, which provides precision guidance during neurosurgery, will assist in advancing care to those in immediate need. Finally, our research efforts have continued to push the envelope for developing new strategies to treat brain and spinal cord dysfunction. Our strategy of genetically modifying adult stem cells to produce extra amounts of beneficial proteins when transplanted into diseased or damaged brains has been adopted by researchers at University of California, Davis, with the expectation that it will be clinically tested for treating Huntington’s patients within the next four years. In addition, our work to produce induced pluripotent stem cells that can replace lost neurons in the brains or spinal cords of those in need, continues to progress. Although our progress has been hampered by the unforeseen accident to one of our top researchers, Dr. Julien Rossignol, in January, we have continued to forge ahead. Fortunately, Dr. Rossignol has fully recovered and is back to work full-time in the FNI lab at CMU. In addition to the setback from losing the extraordinary contributions of Dr. Rossignol, FNI is facing the same sort of budgetary cutbacks that many people and organizations are facing in these tough economic times. Nonetheless, we are determined to focus on our mission and continue to provide the best education, care, and research that we possibly can to help those who need it most. Our resolve has been strengthened by the enormous support that we have again received from our fall fundraiser this year. The outpouring of the generous contributions from our FNI family has allowed us to make a significant donation towards purchasing the new Stealth System at the hospital and key pieces of lab equipment—including a spectrophotometer—that will keep FNI research at the cutting edge. Our work at FNI is a communal effort, requiring commitment from our staff, volunteers, Board members, and community supporters. Our continued success is dependent on the generous support and contributions of our FNI family—together, we can make a significant difference in the lives of so many who suffer from neurological disorders—the very people who are most grateful for our collective efforts. So, as we count our blessings this holiday season, we want to make sure that there is ‘thanks given’ to all of you—our FNI family— who continue to demonstrate the steadfast commitment to do as much as we can for those who need it most. 2 FNI Lab at CMU Collaborating with University of California, Davis on Major Study for Treating Huntington’s Disease (HD) On Friday, August 03, 2012, the following announcement, which included acknowledgement of the groundbreaking work done in the FNI lab at CMU, was released to the public (and was subsequently referenced in a special issue on stem cells in the November 18th issue of the Detroit Free Press): California stem cell agency approves $19 million clinical trial project as Huntington’s disease families ‘change the course of science’ Adult stem cells designed to rescue brain cells from death in Huntington’s disease patients could enter human testing in the next three to four years, thanks to a $19 million grant to an HD research team at the University of California, Davis (UC Davis), from the California Institute for Regenerative Medicine (CIRM). If successful, this first-ever stem cell clinical trial for Huntington’s could pave the way for a possible treatment of the devastating disorder. At a public meeting July 26, the oversight board of the $3 billion stem cell agency announced the award to the lab of researcher Jan Nolta, Ph.D., a recognized specialist in mesenchymal (pronounced “meh-zen-KI-mal”) stem cells (MSC), and her collaborator Vicki Wheelock, M.D., a neurologist and the director of the Huntington’s Disease Society of America’s Center for Excellence for Family Services and Research at UC Davis. Dr. Nolta aims to introduce MSCs, which act as natural “paramedics” in the body, into the brains of symptomatic HD patients to test for safety and tolerability. The trial doses will be made from a sample of MSCs extracted from a healthy donor. MSCs produce a so-called “fertilizer for the brain” (BDNF, brain-derived neurotrophic factor), whose levels plummet drastically when someone has HD. Dr. Nolta and her team have engineered MSCs to produce higher levels of BDNF in an attempt to help HD-damaged neurons recover and avoid death, thus slowing, halting, or perhaps even reversing the course of HD. Dr. Nolta’s collaborator Gary Dunbar, Ph.D., of Central Michigan University, has already demonstrated that these MSCs mostly stop symptoms in transgenic mice that have been given the abnormal HD gene. Research in the FNI lab at CMU demonstrated that bone-marrow-derived MSCs from mice, which were subsequently altered genetically to produce extra amounts of a beneficial protein (called brain derived neurotrophic factor) could significantly reduce anatomical and behavioral deficits in a transgenic mouse model of Huntington’s disease. As part of the new collaboration, FNI researchers plan to test human MSCs, developed in the UC Davis lab, in the same mouse model of Huntington’s disease. If successful, the next step would be for the UC Davis group to test these in non-human primates, prior to initiating human clinical trials, a goal they hope to accomplish within the next four years. 3 Jeff Smith is President-Elect for the Faculty for Undergraduate Neuroscience Dr. Jeffery Smith, E. Malcolm and Lois Field Endowed Chair of Health Sciences at SVSU, was recently elected to serve as the next President of the Faculty for Undergraduate Neuroscience, an international organization dedicated to promoting teaching and research in the neurosciences at the undergraduate level. Dr. Smith has an exemplary record of mentoring undergraduate students and has served with distinction as a counselor for this organization for past few years. He has been a major impetus in establishing the new neuroscience laboratory and mentoring neuroscience students at SVSU. In addition, Dr. Smith is serving as Counselor-at-Large in the Michigan Chapter of the Society for Neuroscience. His election as the next President of the Faculty for Undergraduate Neuroscience is a testament to his dedication and commitment to undergraduate education in the neurosciences. SVSU Professor and Student Honored Dr. Charles Weaver, former Research Associate at FNI and current Assistant Professor at SVSU, and his student, Robert Underly, were honored as one of five recipients of the Support of Mentors and Students Award at this year’s banquet on October 13th at the Society for Neuroscience in New Orleans, Louisiana. This is a national award offered to outstanding junior faculty members at predominately undergraduate institutions who demonstrate excellence in research and a commitment to promoting diversity in neuroscience education. The awardees are selected from a highly competitive pool of research proposals submitted by applicants across the country. The applications are then scored and reviewed by a panel of experts, and the top candidates are granted funds to help the mentor and his or her student conduct the proposed research over the summer. Dr. Weaver’s project focused on his hypothesis that some elements of Alzheimer’s disease (AD) could be linked to a bacterial infection from Enterococcus faecalis (a major cause of loss of teeth). Dr. Weaver and his student detected shifts in tau protein from the cell body to degenerating axons in cultured neurons that were exposed to the Enterococcus faecalis bacteria. They also found evidence that the tau protein changed it shape in the cultured neurons exposed to the bacteria, mimicking what happens to tau protein in AD, and suggesting a possible link between Enterococcus faecalis and AD or other disorders involving disruption of the tau protein. Dr. Weaver and his students are continuing to pursue this line of research and are collaborating with FNI Research Associate, Dr. Mee-Sook Song, to better understand the potential causes of AD, so that effective treatments can be developed. St. Mary’s Achieves Stroke Center Recertification Following an on-site evaluation on September 21, 2012, and by demonstrating compliance with nationally developed standards for stroke care, St. Mary’s of Michigan has earned The Joint Commission’s Gold Seal of Approval™ as a Primary Stroke Center. St. Mary’s first became certified in 2006. Every two years The Joint Commission conducts an on-site review of the program. Each year, about 795,000 people experience a new or recurrent stroke, which is the nation’s 4th leading cause of death. On average, someone suffers a stroke every 40 seconds and someone dies of stroke every 3.1 minutes. Stroke is the leading cause of serious, long-term disability in the United States. The capabilities of St. Mary’s of Michigan to attend to an acute stroke have continued to advance through the years. We are able to provide interventions above and beyond the standard intravenous tPA (tissue plasminogen activator) with a variety of treatment options that are now available in the interventional radiology department. 4 St. Mary’s is proud to have achieved this designation from the Joint Commission and are pleased to have them recognize our commitment to providing the best possible care to patients and the community. Fall Fundraiser Allows FNI Research to ‘Step Ahead’ The concerted efforts of FNI staff, board members, and volunteers—especially the tireless dedication of our Chairperson and chief fundraiser, Martha Ann Joseph—has provided the tools to propel FNI research to new heights. The acquisition of the flow cytometer, incubator microscope, and the initiation of the research fellowship have positioned FNI to be a significant source of ground-breaking research on the efficacy of adult stem cells for treating neurological disorders. Over the past four years, the FNI lab in Saginaw has been transformed into a state-of-the-art research facility that is better positioned to generate new insights into the cellular and molecular mechanisms underlying neurological dysfunction. These insights can then be translated into developing new therapeutic strategies that can be tested at the cellular level at the FNI lab in Saginaw and in animal models of neurological diseases in our affiliated labs at SVSU and CMU. For example, Dr. Nicholas Dey has been working with researchers at SVSU on a project to evaluate how changes in cell culture conditions, such as the amount of oxygen to which cultured cells are exposed can affect their hardiness. In addition, his recent work, investigating the potential of tumor formation and immune rejection of cells grown in normal and low oxygen environments, may provide critical information into the clinical utility of these cells for transplantation therapy. Currently, FNI researchers will be purchasing a spectrophotometer from part of the proceeds garnered from this year’s FNI Fall fundraiser (Field of Hope: Steps Ahead). This spectrophotometer will allow for the analysis of cellular changes, chemical release, and protein expression in living cells, greatly enhancing the speed and scope of research into the treatment of neurological diseases and injury. This will allow researchers to gain a deeper understanding of the underlying mechanism of diseases, by evaluating changes in their biochemical and cellular components, as well as monitoring the mechanisms by which potential treatments might confer their beneficial effects. For example, the spectrophotometer can measure the release of pro-survival chemicals in cells grown under different conditions, and this information can help identify the most effective method of growing cells to maximize their efficacy when they are transplanted into the brain or spinal cord. The acquisition of the spectrophotometer and other key pieces of equipment (including a gel imaging system, highspeed centrifuge, and new PCR machine) from this year’s fall fundraiser will provide the critical infrastructure needed for the exciting new line of research being undertaken by FNI’s newest research associate, Dr. Mee-Sook Song. This equipment will allow her to investigate the progression of neurodegenerative processes that occur during the early phases of Alzheimer’s disease (AD) by monitoring cultured neurons obtained from both healthy mice and those carrying genes that cause AD. Dr. Song will investigate whether co-culturing AD neurons with healthy bone-marrow-derived mesenchymal stem cells (MSCs) can delay the progressive degeneration of the AD neurons. This study will address what mechanisms that are involved in the neurodegenerative processes and will examine whether the healthy co-transplanted MSCs can produce beneficial proteins (such as brain derived neurotrophic factor) that may prevent or delay the onset of AD pathology. This equipment will also be available for the rich, on-going collaborations between the FNI lab in Saginaw and affiliated labs at SVSU and CMU. The generosity of the supporters of FNI is being translated into significant progress toward understanding the mechanisms underlying neurological dysfunction and potential ways to effectively treat these problems. The continued support of these efforts will hasten the development of new and more effective treatments for a variety of neurological disorders. All of us at FNI (and especially all of those afflicted with these devastating disorders) are deeply grateful for the generous support of our donors. The spectrophotometer, to be purchased with some of the proceeds from this year’s Fall fundraiser, will add a critical piece of equipment to the impressive arsenal used to combat the devastating problems caused by injury or disease to the nervous system. 5 6 7 FNI Research CLINICAL The FNI Clinical Research team is currently conducting trials in the areas of multiple sclerosis (MS), glioblastoma, and sacroiliac joint pain. The following will give a small glimpse into each study that is active at this time. Stratify 2 for monitoring Multiple Sclerosis patients We have 65 subjects enrolled and have started the extension study that will track these patients for four more years. The principal investigator (PI) for this study is Barbara Jahnke M.D. The purpose of the study is to quantify the serological prevalence of JCV ( John Cunningham virus) antibody in the MS population and give the prescribing physician and patients receiving Tysabri more accurate information of their risk for developing PML (progressive multifocal leukoencephalopathy). The official title of the study is: JCV Antibody Program in Patients with Relapsing Multiple Sclerosis Receiving or Considering Treatment with Tysabri: STRATIFY-2. We have already learned that patients who test positive to the JC virus antibodies, have been on immune suppressants and have more than 24 infusions of Tysabri are at greater risk of developing PML. SI Bone INSITE: Investigation of Sacroiliac (SI) Fusion Treatment. This is a randomized study comparing non-surgical treatments to SI joint fusion. This study is a phase IV with Dr. Lawson and Dr. Schell. We are up and running with this study. CDX-110 Vaccine for Glioblastoma The CellDex-110 phase III study has been approved and FNI clinical researchers are now screening patients. In addition, research continues for the second phase of this research study for the treatment of brain cancer, which involves a long term follow-up. FNI Hosts 2012 International Organization of Multiple Sclerosis Nurses Program The conference, Complex Issues in MS: Creative Nursing Solutions, was held in Detroit on September 15th and hosted and organized by FNI’s Research Nurse, Heather Clark. Seventy-nine nurses attended the day-long conference and gave excellent reviews at its conclusion. Topics and speakers included: • Wellness in MS and the Role of MS Nursing, by Heather Clark RN • Nature of MS: Epidemiology, Diagnosis, Natural History and Clinical Course, by Richard Herm RN • Disease Management: Acute Relapses and Disease Course, by Barbara Jahnke MD • Functional Changes, Role of Rehabilitation and the Management of Progressive MS, by Daniel Duffy D.O. • Comprehensive Symptom Management with Case Studies, by Marc Silverman D.O. 8 PRE-CLINCIAL FNI Researchers Present Findings at National Conference Researchers from the FNI Lab at CMU gave over 20 presentations at this year’s annual meeting of the Society for Neuroscience in New Orleans, Louisiana this past October. The researchers presented their work on the use of adult stem cells for treating neurological deficits in a wide variety of disorders, including Alzheimer’s disease, Huntington’s disease, Parkinson’s disease, degenerative disc disease, and stroke. The Society for Neuroscience meeting is the largest and most prestigious meeting of its kind, attracting over 28,000 neuroscientists from around the world. The FNI presentations were well received and helped position our research in the forefront of international efforts to utilize adult stem cells, particularly induced pluripotent stem cells (genetically-altered adult stem cells that contain the capacity to become any kind of cell), for treating neurological disorders. Back row (L-R): Robert Wyse (graduate assistant), Jessica Matyas (graduate assistant), Dr. Julien Rossignol (principle investigator), Dr. Gary Dunbar (principle investigator), Kyle Fink (graduate assistant), and Ryan Welchko (graduate assistant). Front row (L-R): Dr. Jessica Mathchynski (former graduate assistant, now Assistant Professor at Rochester College), Tiffany Reinke (undergraduate student), Tia Hall (undergraduate student), Rebecca Culver (undergraduate student), Philip Starski (undergraduate student), and Andrew Crane (graduate assistant). FNI Researcher Receives State and National Honors Tiffany Reinke, an undergraduate researcher in the FNI lab at CMU, shared highest honors as one of the two winners in this year’s Michigan Chapter of the Society for Neuroscience outstanding undergraduate research poster competition. This was the fourth year in a row in which an FNI researcher won this award, and marks an astonishing record of six of the last eight winners of this state award coming from the FNI lab at CMU. Tiffany’s work represented a follow-up of the work initiated by Dr. Jessica Matchynski, a recent graduate of CMU’s Ph.D. Program in Neuroscience. Tiffany worked in the FNI lab at CMU on a project testing the efficacy of a combinatorial treatment for memory deficits in a mouse model Tiffany Reinke (right) and her of Alzheimer’s disease. Tiffany found that treatments of Total Body Rhythm (a compound mentor, Dr. Gary Dunbar (left), were honored by the Faculty for consisting of tart cherry extract, Nordic fish oil, and Emu oil, made by Cerise Nutraceuticals in Undergraduate Neuroscience Traverse City, Michigan) could reduce memory deficits in the 5xFAD transgenic mouse model at this year’s Society for of Alzheimer’s disease. In a follow up to her behavioral work, Tiffany also showed that the Neuroscience Meeting in New Orleans, Louisiana. Cerise product helps to preserve critical cell functioning in this mouse model of Alzheimer’s disease. Tiffany also received honors in a national competition, in which she won a travel award from the Faculty for Undergraduate Neuroscience, to attend and present her research at the national meeting of the Society for Neuroscience. FNI Researcher Wins Regional Award Kyle Fink (pictured at right), a Ph.D. student in the FNI lab at CMU, was the recipient of yet another award this past year. Kyle’s presentation at the Mid-West Stem Cell Conference, held at Oakland University during the first week of October, received second-place honors. This conference was attended by some of the world’s top stem cell researchers, and this honor adds to Kyle’s growing collection of accolades during the past couple of years, including receiving the prestigious international Chateaubriand Fellowship (to spend a year in a top-ranked laboratory in France) and a travel award last year to attend and give a platform presentation at the American Society for Neural Therapeutics and Repair conference in Clearwater Beach, Florida. Kyle’s work has focused on comparing the efficacy of transplanted induced pluripotent stem cells (which are adult stem cells that are genetically altered to function as if they were embryonic stem cells) to that of bonemarrow-derived adult stem cells. Kyle is expecting to complete his studies in the FNI lab at CMU this summer and defend his dissertation for a dual Ph.D. degree, conferred by both CMU and the University of Nantes, in France. 9 In Memory Jeff Coupie August 15th, 1970 - August 5th, 2012 Jeff skydiving Mary Kunz, Jeff Coupie & Tami Bersano at the 2010 FNI Fall fundraiser Jeff playing wheelchair rugby Martha Ann Joseph, Margaret Clark and Jeff at an E. Malcolm Field Society Gala 10 Jeff was a leading advocate for adaptive sports and co-founded Michigan Sports Unlimited (MSU) 12 years ago, with former FNI associate Brian Sheridan. He had been involved with another organization for adaptive golf, which he loved, but funding was running out and his love for adaptive sports was growing. According to Brian, Jeff provided the heart and soul for MSU. He worked tirelessly to grow the organization through presentations, grants and talking to whomever would listen about his passion, even without a salary. Michigan Sports Unlimited has become a leader in adaptive sports. Since 2008, the organization organizes Thunder in the Valley games at SVSU, a three day event of Olympic style games for disabled athletes. In 2011, Jeff was responsible for bringing the National Junior Disability Championships to SVSU, which hosted over 200 young athletes from across the country. One of Jeff ’s favorite sports was quad rugby, and he competed on the team, Michigan Storm. This sport is for people who are quadriplegic, or those who have an impaired mobility in all four of their limbs. Jeff was a C6 quadriplegic, receiving his injury at his high school graduation party after diving into a pool. This left him unable to walk and with little function in his hands and forearms. On October 25th, the Athletes with Disabilities Network presented Jeff ’s friends and family with the Rick Knas Lifetime Achievement Award, celebrating Jeff ’s contributions to the success of others, given at a Hall of Fame banquet at the Sound Board in the Motor City Casino and Hotel in Detroit. Jeff worked closely with several of the FNI staff, including Tami Bersano and MSU Board members Mary Kunz and Maria Gonzalez. Mary and Tami, also wheelchair users, would join with Jeff to meet with newlyadmitted patients in the hospital, shortly after receiving spinal cord injuries. They would convey to the patients that there exists opportunities for them and would try to help them with depression, that is often associated with learning they have a spinal cord injury. Everyone is quickly realizing how hard Jeff worked and how much he accomplished by himself, as they are now trying to learn what will be needed to continue the important job of running the MSU organization, especially now, to honor Jeff, and all that he did for others in need. We all miss him coming into the office occasionally to get mail or check up on things, always smiling and obviously enjoying his work of making the lives of others with disabilities better. FNI Blessings Martha Ann Joseph Chair FNI Board of Directors We are so blessed here at Field Neurosciences Institute to see passionate commitment to our vision and mission from our Board of directors, staff members, volunteers and contributors. It is our intent to continually strive for excellence in clinical, medical education, injury prevention programs and research, searching for the most effective ways to treat those suffering from all the devastating neurological injuries, diseases and disorders. This coming year we are focusing our efforts towards finding effective treatments for Alzheimer’s disease, the most common dementia, which affects nearly 5.3 million Americans. This disease, which causes memory loss and other intellectual deficits that can interfere with daily life, has become one of the most serious health issues of our time. As we all know, it is not just the person suffering from Alzheimer’s that is affected, but we need to include families, caregivers and others whose health, income and financial security suffer irreversible decline. It is known that the risk of developing Alzheimer’s disease significantly increases with age. It is projected that one in eight, over 10 million baby boomers, will either die with, or from, Alzheimer’s disease. Together we see many challenges and also have opportunities to find answers to some of the devastating neurological degenerative diseases, including Alzheimer’s disease. Our FNI scientists, including Dr. Gary Dunbar, our Executive Director, Dr. Mee-Sook Song, and others are leaders in adult stem cell research ventures and collaborations, searching for answers to some of the challenges presented by the devastating neurological degenerative diseases, including Alzheimer’s disease. We now position the Institute so that it can maximize its effectiveness in developing new services and therapies for those suffering from these diseases. With all of your generous partnering, we will continue to look for “miracles” - a world changed dramatically by innovative research, resulting in more effective treatments for many of the dreaded neurological diseases, disorders and injuries. With your generosity, we can adopt the passionate and compelling vision of Malcolm Field, that is, to make a significant difference in the lives of so many people suffering from neurological diseases, disorders, and injuries. On behalf of the Institute, I thank you for your continued support. You are our lifeline! “Life goes fast, and it can pass you by in a hurry. I have a very good life and I choose to enjoy it to the fullest.” - Jeff Coupie 11 New CNRNs Three Registered Nurses were awarded the CNRN (Certified Neuroscience Registered Nurse) Certification this year. The CNRN Certification provides recognition for a level of excellence in nursing care for the patient with a neurological condition. After two years of service in the Neuroscience Department, all registered nurses are eligible to prepare and sit for this highly distinguished certification test. To date, over 60 registered nurses have been certified. Congratulations to our newest CNRN’s: Eric Maher, RN- NICU Len Ferris, RN- NPC Vicki Gamet, RN- NPC 27th Annual Neuroscience Nursing Conference - This, That and the Other Thing October 23rd at St. Mary’s of Michigan Masud Lecture Hall Approximately 100 attendees earned 6.25 continuing education contact hours for attending the conference, which was organized by St. Mary’s of Michigan Department of Neurosciences associates and management. This year’s conference included the following speakers and topics: E. Malcolm Field, MD, DSC, FACS, FAICS, ABNS - Welcome Zigmond Kozicki, DHA, MSA, MA, LLP - Post Traumatic Stress Disorder after Motor Vehicle Accident Daniel Duffy, D.O. - Walk this Waylll Emerging Stroke Research Daryl Jensen, RN - From Donation to Transplant-An Unbroken Chain Stephanie Staples - Life Support for Nurses Gerald Schell, MD, ABNS - Aneurysm: Past, Present and Future of Treatment Suhasini Gudipati, MD, FACP - Prions, Prions, Prions ThinkFirst Receives Grant from Mt. Pleasant Area Community Foundation’s Kellogg Youth Fund FNI’s ThinkFirst program received a grant to provide helmets for 3rd graders in Mt. Pleasant area schools. In addition to providing the helmets, FNI’s ThinkFirst group also delivers the Buckle Your BrainTM program. The mission of Buckle Your BrainTM is to help prevent brain and spinal cord injuries by educating the youth of our community about the critical functions of the brain and spinal cord, and by reinforcing helmet use and other good safety behaviors. The Buckle Your BrainTM Program is presented by Injury Prevention Specialists who are dedicated to making people aware of the dire consequences that could occur when safety helmets are not worn. The program addresses bicycle safety, proper helmet utilization, and the critical functions of the brain and spinal cord. The 60-minute educational presentation stresses the importance of wearing a safety helmet to protect the brain and ultimately save a LIFE. After a brief anatomy lesson, participants view a bicycle safety video. This is followed by a high energy interactive quiz which covers the rules of safe bike riding. To reinforce the importance of wearing a helmet to protect the brain, educators use a watermelon to demonstrate to the students the risks of not wearing a helmet. The watermelon is dropped, both with and without a helmet. The helmeted melon is not damaged while the un-helmeted melon cracks or explodes, demonstrating the injuries they could sustain. At the end of the presentation, each child is custom fitted with a bike helmet and read their “safety rights,” promising to wear their helmet to protect their brain. Included were Vowles, Pullen, Shepherd and Ganiard, Winn, Sacred Heart Academy, Renaissance Academy and Beal City elementary schools. Neuroscience Golf Outing The annual golf outing was held August 25th at Apple Mountain Golf Course in Freeland. More than 120 golfers and volunteer participated this year and over $15,000 was raised for continuing education and certification of St. Mary’s Neuroscience department. The keynote speaker, Dr. Daniel Duffy, presented the most up-to-date information regarding anabolic steroids, while the attendees enjoyed a wonderful hot breakfast. At 9:00 am there was a shotgun start for golf. The volunteers kept the day fun with all sorts of games at different holes. Three large screen TV’s and one iPad were raffled off to help raise funds to further neuroscience education. There were many other fine gifts awarded throughout the day. The mood of the day was FUN, FUN, FUN! 12 Tami Bersano with Pullen Elementary students Kelli Jankens with Vowles Elementary students Kelli Jankens with Shepherd Elementary students Mary Kunz custom fits a 3rd grader with a helmet ThinkFirst Welcomes Pam Brown Pam Brown is the new ThinkFirst Gratiot and Isabella County teacher, replacing the now retired Joan Klopcic and Jane Brown. Pam will receive a stipend for working in the Isabella County schools from the Gratiot Isabella RESD and an office to do her work. The Nichols Family, who have been incredible supporters of the ThinkFirst program, will continue their support of the Gratiot area program. Pam has a degree in Elementary Education from CMU, has taught as a substitute teacher in the Ithaca Public schools for ten years, has two childrean at Hope College and lives in Ithaca with her husband. 13 2012 E. Malcolm Field Society Spring Gala 2012 Spring Gala and 50 Year Tribute This year’s Gala was held at the Horizon’s Conference Center on May 17th and featured Dr. Eric Gilbertson, President of Saginaw Valley State University (SVSU) and FNI Board member, and Dr. George Ross, President of Central Michigan University (CMU) who gave their perspective of the future of their respective university and how they plan to collaborate with FNI. They, along with Jim Van Tiflin, Martha Ann Joseph, and Gary Dunbar, also congratulated Dr. E. Malcolm Field for his first 50 years of neurosurgery for St. Mary’s of Michigan. The presenters were followed by a tribute documentary that was created early in the year, featuring Dr. Field, St. Mary’s of Michigan, Saginaw Valley Neurosurgery, and FNI. An annual event at the Gala is the neuro nursing scholarship presentation. This year, Dean Judy Ruland from SVSU presented the award to Cindy Chapman. Cindy graduated in 1987 from SVSU with a BSN in nursing. She began her nursing career at St. Mary’s in Neuro Progressive Care where she worked for five years. After a back injury, she continued at St. Mary’s for 13 years in the PreProcedure Testing area. In 2001, she returned to work in NICU, where she has remained. Cindy became CNRN certified in 2006, and is currently working on her MSN as Nurse Practitioner. Upon graduation, she hopes to continue working with the neuro population in the acute care setting. She lives in Freeland with her husband, Steve, and children, Tyler and Bailey. Celebrations at Alpena and Tawas Two special celebrations were held to give patients, physicians, nurses and others a chance to congratulate Dr. Field on his first 50 years of neurosurgery at St. Mary’s. The first event was held in Alpena, on July 21st. The second was held on August 7th, at the Tawas Bay Beach Resort in Tawas. This wonderful event was organized by St. Joseph Health Systems Foundation Executive Director, Shelley Buresch. At these celebrations, people enjoyed refreshments and told stories of how Dr. Field has impacted their lives. In addition, the 50-year tribute DVD was shown. While Dr. Field travels to several other clinic locations in Michigan, it has been difficult to schedule aditional events at this time. However, if you would like to receive a copy of the tribute video, please contact FNI. Dr. Field enjoying a tribute by a Tawas attendee 14 Shelley Buresh and Martha Ann Joseph Dr. Field with an Alpena nurse 15 E. Malcolm Field Society Members FNI News Saginaw Valley Humanities Series features Field Neurosciences Institute This series, held at Saginaw Arts and Sciences Academy, has provided free, enriching programs for 32 years. On October 9th, E. Malcolm Field, M.D. and Gary L. Dunbar, Ph.D. presented an overview of the services provided by FNI, with a focus on the use of adult stem cells to treat neurodegenerative disorders. Attendees learned what adult stem cells are and how they can be genetically modified to increase the therapeutic potential when trasplanted into the brains of rodent models of Huntington’s, Parkinson’s, and Alzheimer’s diseases. Ninth Annual James E. O’Neill Jr. Memorial Lecture Gary Dunbar and Robert Edsel Writer Robert Edsel was the featured speaker at this year’s lecture at Saginaw Valley State University’s Malcolm Field Theatre for Performing Arts on October 25th. Mr. Edsel presented “The Monument Men: Allied Heroes, Nazi Thieves and the Greatest Treasure Hunt in History”, his book from 2009. Mr. Edsel established the Monuments Men Foundation for the Preservation of Art, an organization that in 2007 became one of 10 recipients of the National Humanities Medal. The day after his lecture, Mr. Edsel joined FNI Board members and staff for a luncheon and discussion of his book and his experiences learning about the stolen art and acts of art preservation during the World War II. Alzheimer’s Panel for General Public Planned - January 17th, 2013 Watch for information on a special grand rounds to educate the public on current research being done at FNI, CMU, and SVSU in the field of Alzheimer’s Disease. FNI’s Research Associate Dr. Mee-Sook Song, who specializes in this Alzheimer’s research, along with Dr. Gary Dunbar, Dr. Charles Weaver and others will present current information and answer questions by attendees. Please come and learn about potential treatments for this terrible disease that affects so many of our loved ones. A dinner buffet will be provided for this evening event which is planned for January 17th at St. Mary’s of Michigan’s Masud Lecture Hall. Details will be posted on www.fni.org, FNI’s facebook page and emailed. To join the email mailing list, please contact cheri.burk@stmarysofmichigan.org Support Groups 16 Multiple Sclerosis 6:30 pm - 8:00 pm December 11, 2012 January 8, 2013 February 12, 2013 March 12, 2013 Spinal Cord Injury Resource Group 5:30 pm to 7:00 pm contact: Heather Clark hclark@stmarysofmichigan.org or 989-497-3023 contact: Mary Kunz mkunz@stmarysofmichigan.org or 989-497-3075 January 15, 2013 March 19, 2013 (both held at St. Mary’s of Michigan Towne Centre conference room) PROTECTOR A & D Home Health Care, Inc. Absolute Building Maintenance Advanced Diagnostic Imaging, P.C. Dr. Raana Akbar & Dr. Waheed Akbar Waheed Akbar M.D. & Raana Akbar M.D., P.C. Amendia, Inc. Anonymous Antique Warehouse & Speciality Shops Arthur Webster Jr. Endowment Fund Avalon & Tahoe Manufacturing, Inc Dr. & Mrs. Edgar P. Balcueva Charles F. and Adeline L. Barth Charitable Foundation Bierlein Companies Patricia F. Bierlein Mr. & Mrs. Joseph C. Bommarito Arnold & Gertrude Boutell Memorial Fund Mr. and Mrs. Marvin Brandle Braun Kendrick Finkbeiner P.L.C. Mr. & Mrs. John D. Bueker Bueker Development Inc. Mr. & Mrs. Carl Burk Catholic Diocese of Saginaw Catholic Federal Credit Union Central Michigan University, College of Medicine Central Michigan University, College of Humanities & Social & Behavioral Sciences Dr. & Mrs. Joseph W. Chatfield Citizens Bank C. K. Eddy Memorial Fund Margaret E. Clark Tom & Joanne Cline Davenport University Dr. & Mrs. Delmer J. DeHart Delphi Corporation Dow Corning Dr. Daniel Duffy Dr. Gary Leo and Deborah Sue Dunbar Mrs. Betty Dunbar Duro-Last Roofing Mr. & Mrs. William J. Ewald Dr. & Mrs. E. Malcolm Field E. Malcolm & Lois Field Foundation Mr. & Mrs. Frank E. Field Mr. & Mrs. Irving A. Field FNI Physical Medicine & Rehabilitation, P.C. Mr. & Mrs. Fred L. Fraizer, Jr. Fraternal Order of Eagles Auxiliary Mr. and Mrs. Louis J. Furlo Dr. Adam E. Gamon Garber Management Group Garr Tool Great Lakes Eye Institute Mr. & Mrs. Eugene J. Hamilton Mr. & Mrs. Louis E. Hanisko Harvey Memorial Foundation HealthPlus of Michigan HealthSource Saginaw Martha Ann Joseph Mr. & Mrs. Joseph P. Kelly Mr. & Mrs. James E. Keyes Mr. & Mrs. Michael Kremin, Jr. Mr. & Mrs. Thomas J. Lawler Mr. & Mrs. Leonard H. LeFevre Lighthouse Neurological Rehabilitation Center Ms. Barbara M. Mahar Lincoln Mr. & Mrs. Edward A. Lunt Dr. & Mrs. Lakshmana R. Madala Mail Room Service Center, Inc. Mr. and Mrs. Joseph J. Majeski Dr. Luigi & Dr. Carlotta Maresca Mr. & Mrs. Henry G. Marsh Angie Maziarz The Honorable & Mrs. Gary R. McDonald McDonald Historic Auto Foundation Mr. & Mrs. Thomas W. McDonald. Mr. & Mrs. John W. McGraw Medtronic Surgical Navigation Michigan CardioVascular Institute Michigan Orthopedic Services, L.L.C. Midwestern Surgical Associates Mobile Medical Response, Inc. Morley Companies, Inc. Morley Foundation Dr. Joseph R. Moskal Mr. & Mrs. David M. Nichols Nichols Financial Group Kevin D. Nichols Dr. & Mrs. Jacob C. Ninan O’Grady & O’Neil, P.C. Pain Consultants of Michigan Patricia B. Peplinski-Acker Family Trust Pfizer Inc. PNC Bank Rehabilitation Research Center Riversbend Rehabilitation Inc. James L. Rogers Saginaw Bay Underwriters Saginaw Community Foundation Saginaw Radiotherapy Saginaw Valley Neurosurgery, P.C. Saginaw Valley State University Dr. & Mrs. Gerald Schell Mr. & Mrs. Raymond J. Schultz Raymond J. and Monica E. Schultz Trust Dr. & Mrs. Samuel H. Shaheen Stan & Kevin Sobol Sons of Italy Lodge 2456 Spineology, Inc. Spence Brothers St. Joseph Health System St. Mary’s of Michigan Philip J. Stahle Harold R. Stern Cecil & Helen Szepanski Mr. & Mrs. Gerald J. Talbot The F. P. Horak Company The Manors LLC The Rehmann Group Timberline Emergency Physicians, P.C. Total Spine Midwest LLC Alice E. Turner Memorial Trust Valley Anesthesia, P.C. Valley Cardiology, P.C. Mr. & Mrs. James M. VanTiflin Dr. & Mrs. Robert L. Vitu Mr. & Mrs. Patrick Walsh Arthur Webster Jr. Endowment Fund Leroy & Marcia Westrick Jason & Carol White Wickson-Link Memorial Foundation Dr. & Mrs. David Wiersema Dr. Susan Schmiege & Mr. Jim Wilson Mr. & Mrs. John W. Wolf, Jr. Dr. & Mrs. Michael J. Wolohan Mr. Richard V. Wolohan Wolohan Family Foundation Mr. & Mrs. Lloyd J. Yeo Melvin & Hilda Zuelke Charitable Foundation PATRON Abbott Neurology Care Center Mr. & Mrs. Nate Abney Accuray, Inc. Agility Health Professionals, Inc. Dr. & Mrs. Khurshid Ahmad Mr. & Mrs. Patrick Allen Valerie Allen Anagnost & Hall, P.C. Andersen Eye Associates, L.L.P. Anthony Filippis Co. Dr. & Mrs. Joseph N. Aquilina Mr. & Mrs. Brent D. Atwood Dr. & Mrs. Umeshkumar A. Badami Dr. & Mrs. Leroy C. Barry Jean M. Bass Bay City Players Dr. Ronald & Dr. Sussan Bays B. M. Benchley Michael & Kathy Bierlein Richard & Ann Blazejewski Wallace & Irene Bronner Family Charitable Foundation Mr. & Mrs. Jerry L. Brown Dr. Thomas C. Burk Business Hemlock School Partnership Cadwell Laboratories, Inc. Dr. & Mrs. Donald J. Cady Mr. & Mrs. Craig J. Carmichael W. L. Case and Company Cass City Public Schools Mr. & Mrs. John A. Chasnis Children’s Neuropsychology Assoc. C.M.W. Real Estate, Inc. 17 Copoco Community Credit Union E. Malcolm Field Society Members 18 Dr. & Mrs. David J. Conrad Consumers Energy Elena M. Cordoba Cox, Hodgman & Giarmarco, P.C. Credit Services of Michigan, Inc. DALMAC Fund Tri County Bicycle Association Dr. & Mrs. Thomas E. Damuth Laura Alice Day Dr. Brian C. de Beaubien Mr. & Mrs. Gerald L. Decker The Honorable & Mrs. Joseph DeFrancesco Deisler Funeral Home Mr. Guy R. Demasellis Alma Gilmore Doud Mr. & Mrs. John F. Doyle Marilyn A. Dust East Central Michigan Planning & Development Region Eclipsys Corporation Edgewood Village Mobile Home Park Edwards Men’s Shop Dr. & Mrs. Thomas A. Egleston Mr. Jeffrey Endean & Dr. Myrna Tumacher Dr. & Mrs. Lamberto E. Eugenio Mrs. Barbara Ewend Falk Center for Molecular Therapeutics Judith Farley Miklos Ferber Fifth Third Bank Mr. & Mrs. Ernest Flegenheimer Mr. & Mrs. Mark S. Flegenheimer Dr. & Mrs. Larry E. Fleischmann Mr. & Mrs. J. Michael Fordney Dr. & Mrs. Kenneth J. Forster Dr. & Mrs. Rey A. Franco Frankenmuth Insurance Mr. Richard J. Garber, Jr. Gardey Financial Advisors Gardner, Provenzano, Schauman & Thomas, P.C. Dr. & Mrs. Richard Goldner Dr. Ravi Goyal & Dr. Rashmi Goyal Gratiot Medical Center Gray, Sowle & Iacco, P.C. Grzesiak Rentals Dr. & Mrs. Charles A. Guidot Mr. & Mrs. James F. Hammis Dr. & Mrs. Brian Hancock Dr. & Mrs. Thomas J. Haverbush Heartland Home Health Care Mr. & Mrs. James Hensler Dr. & Mrs. Verne D. Hulce Mary Hughes Huron Medical Center Aarol W. & Elaine M. Irish Family Foundation Mr. & Mrs. Thomas A. Jaffke Mary K. James Kelli Jankens Dr. & Mrs. James J. Jesko Dr. & Mrs. Charles E. Jessup Dr. & Mrs. Jose Mari G. Jurado Jose Mari G. Jurado, M.D., P.C Roger N. Kahn, M.D. Karu Medical Associates Dr. & Mrs. Kizhakepat P. Karunakaran Mr. & Mrs. Richard D. Katz James & Sharon Kaylor Dr. & Mrs. Young H. Kim Drs. Nikolai & Lioudmila Kinachtchouk J.E. Klobucar/J.D. Klobucher Foundation Georgia L. Knapp Dr. & Mrs. Charles Koenig Dr. & Mrs. George H. Koepke Drs. Sam & Lakshmi Kottamasu Kramer Realty Inc. Mr. & Mrs. Dale A. Krueger Chris Kreuger Memorial Golf Outing Dr. Narendra R. Kumar Lake Huron Credit Union Lambert, Leser, Cook, Giunta & Smith, P.C. LandAmerica Lawyers Title Learman Family Foundation Dr. James Letson, Jr. Dr. Jeffrey Levin Mr. & Mrs. Robert W. Loftus Luce, Basil & Collins, Inc. Mr. & Mrs. Jim Luth Dr. & Mrs. William D. MacInnes Dr. Amita A. Maganti & Dr. Bapineedu Maganti Dr. & Mrs. John W. Manning, III Markey Maintenance Services, Inc. Mr. & Mrs. Ronald Marquardt Mr. and Mrs. Mark Maslovich Mr. & Mrs. Terry E. Mast Marlene J. Mauch McDonald Ford Mr. & Mrs. John McGill Lloyd J. McIntyre Medtronic Sofamor Danek Merrill Lynch Michigan Blood Midland Center for the Arts MidMichigan Medical Center Gladwin Mid-Michigan Neurology Mr. and Mrs. Kenneth R. Miller Mrs. Lois Miller Monitor Township Fire Department Sylvia C. Moore Katharyn M. Morley Mt. Pleasant Area Communitiy Foundation - Kellogg Youth Fund Drs. Thomas & Evelyn Mudd Dr. & Mrs. Charles E. Mueller New Hope Valley Assisted Living Home Allen E. Nickless Memorial Foundation Jon & Jennifer Nichols Mrs. Marilyn Nichols Oakland Orthopedic Dr. & Mrs. Dermot D. O’Brien Katherine O’Brien Mr. & Mrs. John F. O’Grady Mr. and Mrs. Rick Ohle Mr. & Mrs. Terence J. O’Neill O’Neill, Wallace & Doyle, P.C. Dana D. Panknin Paramount Rehabilitation Services, P.C. Matthew Pavlovich Shirley Patzwald & Dr. Tyler Haynes Mary W. Princing Dr. & Mrs. Steven Pulver Pumford Construction Inc. Dr. & Mrs. Ramesh P. Raju Dr. Carlos Ramet Dr. & Mrs. K. K. Ravindran Mr. & Mrs. Jack J. Rehmann Nijole Rice Philip L. Richards Mr.& Mrs. Clement J. Richter Hiel and Mary Rockwell, Jr. John & Barbara Roberts Rock Promotions Rogers Realty Ted Rogers Mr. & Mrs. James E. Rozek Dr. & Mrs. Frank Rugani Saginaw Charter Township Saginaw Intermediate School District Saginaw Medical Federal Credit Union Dr. and Mrs. Naman Salibi Sam’s Club Foundation Sandusky Community Schools George & Jeanne Lound Schaller Susan Schmiege, M. D. Dr. Caroline G. M. Scott Brandon Sebald Sebewaing Chamber of Commerce Select Specialty Hospital Seney Enterprise Peter & Kari Shaheen Dr. Deborah A. Shear Dr. & Mrs. Farhad K. Shokoohi Dr. & Mrs. Gerald A. Sieggreen SignTec Ed & Suzanne Skrelunas Special Tree Head Injury Services In memory of Thomas L. Spence Dr. Chander W. Srinivasan & Dr. Bala Srinivasan Patrick & Annette Stainsby Martin H. Stark Robert E. Stark & Martin H. Stark Foundation Fund State of Michigan Stevens Van Lines, Inc. Mr. & Mrs. Richard Stringer Sturtz & Sturtz, P.C. Surgical Solutions Kathleen M. Sutto Swan Valley Country Club Mr. and Mrs. John J. Swartz Cecil & Helen Szepanski Mr. & Mrs. Paul Tacey G. Anthony Talbot The Dow Chemical Company The Harold C. & Janet A. Baldauf Foundation Mr. & Mrs. Mark Thompson Dr. & Mrs. Dennis Tibble Dr. & Mrs. George K. Tong Tri Valley Landscaping Inc. Tri-County Bicycle Association Tri-Star Trust Bank Mr. & Mrs. Marvin Turner Tyco Healthcare/US Surgical/Valley Lab Venture Medical, Inc. Verdoni Productions Dr. Thomas J. Veverka Wal-Mart Foundation Mr. & Mrs. Charles Weaver Joan Wendland Dr. Paul T. Werner Margaret C. White Mr. & Mrs. William Whitehead Wildfire Credit Union Tom Williamson Wolgast Corporation Dr. Edwin Wright Wright & Filippis, Inc. Fleury Yelvington & Dr. Barry Solomon Yeo Family Foundation Pervez Yusaf, M.D. Paul Zebrowski and Assoc. Craig A. Zanot Scott Zimostrad, PhD and Associates PEER ADP David M. Alexander Allergan Roselyn Argyle Dr. Walter C. Averill Mr. & Mrs. Gary Barber Dr. & Mrs. Jack L. Barry Mr. & Mrs. Thomas A. Basil Dr. & Mrs. Norbert E. Baumgartner Dr. & Mrs. Reynold J. Baumstark Bell-Wasik, Inc. Bio-Logic Systems Corp. Dr. & Mrs. Glen Brookshire Dr. & Mrs. Gregory S. Brown Dr. & Mrs. Jack R. Brown Dr. & Mrs. Frederick J. Cady, Jr. Dr. & Mrs. Douglas G. Campbell Central Michigan Community Hospital Central Michigan District Health Department Chaklos, Jungerheld, Hahn & Washburn, PC. Dr. & Mrs. James L. Chapman Dr. & Mrs. John F. Collins Asa T. Compton Hon. & Mrs. William A. Crane Crooked Creek Investment Company Patrick Curtis Chevrolet-Oldsmobile-Cadillac Daniel J. Dijak, Sr. Dr. & Mrs. Nikolay Dimitrov Lawrence T. Doyle Mr. & Mrs. James L. Duchaine Dr. Jerry J. Evans Farm Bureau Insurance – Mr. Robert W. Pike Burt & Linda Fettig J. Michael Fordney, P.C. Dorothy Foulds Thomas L. Frank Garb-Ko, Inc. Mr. & Mrs. Frederick C. Gardner Mr. & Mrs. James S. Goetz Stan Gorzinski Dr. & Mrs. Rajiva Goyal Mr. & Mrs. Delford Gronholz Drs. Rao V. & Suhasini Gudipati Guilford Pharmaceuticals Jacob C. Hanes Helping Hands Nursing Services Dr. Richard Heuschele Hicks Studio of Saginaw & Midland Hill-Rom Dr. Ronald Hines Holy Trinity Booster Club Horizons Conference Center Huron Medical Foundation Dr. Thomas J. Hyde J & B Products LTD Jim Jasienski Mr. & Mrs. Patrick Joslyn Mr. & Mrs. William Jungerheld Mr. & Mrs. Tim Kelly Mr. Ernie Klee Kohl’s Dr. & Mrs. Samuel Kurn Kurtz Gravel Co Medley A. Larkin, D.O. Mr. and Mrs. Bernard C. Letherer Michael A. Linn Mr. & Mrs. Bob Lofiego Mr. & Mrs. Tim Mac Kay Mr. & Mrs. Edwin Meyer Mid-Michigan Surgical Specialists, P.C. Midwest Prostate & Urological Institute Mr. & Mrs. William Nason Mr. & Mrs. Theodore L. Nelson Mr. & Mrs. William Nichols Lois Niethammer Nortel Dr. and Mrs. Frederick O’Dell Mr. James E. O’Neill Ms. Margaret R. O’Neill Dr. Joseph Oesterling Dr. Rustico B. Ortiz Dr. & Mrs. Sunil P. Pandit Dr. & Mrs. Che Song Park Primary Care Practice, P.C. Princing & Ewend Mr. & Mrs. Harry Putnam Putnam Putnam & Assoc. Dr. Surendra Raythath RS Medical Saginaw River Development Saginaw Valley Bone & Joint Center, P.C. Lewis F. Sandel, M.D Dr. Raghu Sarvepalli Senior Home Health Care, Inc. Mr. & Mrs. Philip Serier John M. Sheridan, D.D.S., P.C. Shred Experts, LLC Mr. & Mrs. Alfred D. Socha Sovis Insurance Agency Dr. & Mrs. Timothy E. Spencer Spring Arbor College Standard Electric Company Standish Community Hospital Medical Staff Mr. & Mrs. George Stewart Superior Home Healthcare Ultra Derm Systems Mr. & Mrs. Bill Valler Dr. John Vincent, Jr. Mr. & Mrs. David A. Wallace Walmart E. Ann Walsh Mr. & Mrs. Richard Watson Wilcox Professional Services Wilkes Broadcasting, LLC MI Dr. Terri L. Williams Yeo & Yeo, P.C., CPAs & Business Consultants In Memory of Judy Bannan Margaret E. Clark Vernon V. Bass, MD. Jean M. Bass Alvin Benson The Krohn Family Beverly Brethauer Antique Warehouse & Specialty Shops Robert Dietzel Leonard & Geraldine LeFevre Donald J. Donahue Margaret E. Clark Martha Ann Joseph Leo A. Dunbar Betty J. Dunbar Zeke Field Dr. and Mrs. E. Malcolm Field Alphone and Ernestine Holihan James E. Rozek Nancy Kovacs Dorothy Spiekermann 19 4677 Towne Centre, Suite 101 Saginaw, MI 48604 989-497-3117 Phone 989-497-3119 Fax www.fni.org In Memory of (cont.) Richard J. Kulow Kathryn Kulow June McIntyre Lloyd J. McIntyre Margaret Nichols Martha Ann Joseph Mark Richter Terry, Jayne, Jill, Mary, Sue and Jeff Tithof Donald Scharich Betty Claus Ted & Regina Humpert Ken & Joyce Laatsch Frank Morlick Chuck Nichols Pro Med Billing Mr. and Mrs. Robert Redding Jim & Jody Richter Gary & Sharon Scharich Lori A. Scharich Shirley Scharich Todd Scharich Randy & Kellie Swartz Calvin and Pauline Weaver Charles Weaver In Honor of E. Malcolm Field, MD Carl and Peggy Burk Pervez Yusaf, M.D., P.C. Mike and Barbara Slasinski Elynor I. Kazuk John and Marilyn Wolf ’s 50th Wedding Anniversary Joseph C. Bommarito Jane A. 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