BIOGRAPHICAL SKETCH
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NAME
POSITION TITLE
Tang, Simon Yue-Cheong
Assistant Professor, Orthopedics, Washington
University in St. Louis
EDUCATION/TRAINING
INSTITUTION AND LOCATION
University of California, Berkeley
Rensselaer Polytechnic Institute, Troy NY
Rensselaer Polytechnic Institute, Troy NY
University of California, San Francisco
DEGREE
(if applicable)
MM/YY
B.S.
M.S.
Ph.D.
Postdoc
8/99-5/03
8/03-5/05
8/03-12/07
2/08 – 8/12
FIELD OF STUDY
Mechanical Engineering
Biomedical Engineering
Biomedical Engineering
Orthopedic Surgery
Positions and Honors
Positions and Employment
1999-2000
Instructor, Computer Science, Univ Calif Berkeley
2000-2001
Unit supervisor, Information technology, Univ Calif Berkeley
2001-2003
Staff research technician, Mechanical Engineering, Univ Calif Berkeley
2003-2004
Graduate student instructor, Biomedical Engineering, Rensselaer Polytechnic Institute
2003-2007
Graduate research assistant, Biomedical Engineering, Rensselear Polytechnic Institute
2009-2012
Adjunct Assistant Professor, Department of Mechanical Engineering, Univ of the Pacific, CA
2008-2012
Postdoctoral Fellow, Orthopedic Surgery, Univ Calif San Francisco
Other
20032004200520062009-
Experience and Professional Memberships
Member, Orthopedic Research Society (ORS)
Member, Reviewer, Biomedical Engineering Society (BMES)
Member, Reviewer, International Bone and Mineral Society (IBMS)
Member, Reviewer, American Society of Bone and Mineral Research (ASBMR)
External Reviewer, National Science Foundation, Systems and Processes Division
Honors
2006 American Society of Mechanical Engineers – Bioengineering Div. Honorable mention paper.
2006 Webster Jee Young Investigator Award. International Chinese Hard Tissue Society.
2007 National Research Council Postdoctoral Fellowship – The National Academies.
2007 Alice Jee Young Investigator Award - NIH Sun Valley Workshop on Skeletal Biology.
2008 Karen and Lester Gerhardt Prize in Science and Engineering – Rensselaer Polytechnic Institute
2008 Zelda and David Gisser Prize in Biomedical Engineering – Rensselaer Polytechnic Institute
2009 UCSF Postdoctoral Travel Award
2009 Program for Breakthrough Biomedical Research Award – UCSF-Sandler Foundation
2010 Ruth L. Kirschstein National Research Service Award Postdoc Fellowship (F32) – NIAMS
2010 Young Investigator Award – Bone Hierarchical Simulation Workshop – UCLA
2012 John A. Haddad Young Investigator Award – Society for Advances in Mineral Metabolism and the
American Society for Bone and Mineral Research
2012 Ellison Medical Foundation Fellow – Fellowship for Molecular Biology of Aging at the Marine Biology
Labs in Woodshole, MA
2012 Harold M. Frost Young Investigator Award – Sun Valley Workshop on Musculoskeletal Biology and
American Society for Bone and Mineral Research
Selected Peer-reviewed Publications
1. Hernandez CJ, Tang SY, Baumbach BM, Hwu PB, Sakkee AN, van der Ham F, Degroot J, Bank RA,
Keaveny TM. 2005. Trabecular microfracture and the influence of pyridinium and non-enzymatic glycationmediated collagen cross-links. Bone. 2005, Dec;37(6):825-32.
2. Tang SY, Zeenath U, Vashishth D. 2007. Effects of Non-enzymatic Glycation on Cancellous Bone
Fragility. Bone. 2007, Apr;40(4):1144-51.
3. Tang SY and Vashishth D. 2007. A non-invasive in vitro technique for the three-dimensional quantification
of microdamage in trabecular bone. Bone 2007 May;40(5):1259-64.
4. Tang SY, Sharan AD, Vashishth D. 2008. Effects of collagen crosslinking on skeletal tissue fragility.
Clinical Biomechanics. 2008, Jan;23(1):122-3.
5. Tang SY, Allen MR, Phipps R, Burr DB, and Vashishth D. 2009. Effects of non-enzymatic glycation on the
mechanical behavior of canine bone following 1-year bisphosphonates treatment. Osteoporosis
International. 20(6):887-94.
6. Hansma PK, Hongmei Y, Schultz D, Rodriguez A, Yurtsev, Orr J, Tang SY, Miller J, Wallace J, Zok F, Li
C, Souza R, Proctor A, Brimer D, Solan XN, Mellivosky L, Pena MJ, Ferrer OD, Matthews P, Randall C,
Kuo A, Chen C, Peters M, Kohn D, Buckley J, Li X, Pruitt L, Perez AD, Alliston T, Weaver V, Lotz JC.
2009. A Handheld Instrument for Quantifying Mechanical Properties of Tissues. Annual Review of
Scientific Instruments. 80(5): 054303.
7. Tang SY and Vashishth D. 2010. Non-enzymatic glycation alters microdamage formation in human
cancellous bone. Bone. 46(2010):148-54.
8. Gourion-Arsiquaud S, Allen MR, Burr DB, Vashishth D, Tang SY, and Boskey AL. 2010. Bisphosphonates
treatment modifies the mineral and matrix bone properties and increases bone heterogeneity. Bone. 46
(2010):666–672.
9. Tang SY and Vashishth D. 2008. Cohesive modeling of the effects of nonenzymatic glycation on the
fracture resistance of bone. Journal of Biomechanics 44(2):330-336.
10. Tang SY, Mathews P, Randall C, Yurtsev E, Fields K, Wong A, Kuo A, Alliston T, and Hansma PK. 2010.
The validation of a new method for testing polymers: the in situ materials characterization using the tissue
diagnostic instrument. Polymer Testing. 29(2010):159-63.
11. Geurts P, Zhao L, Gnesa E, Jeffery F, La Mattina C, Fraz A, Tang S, Vierra C. 2010. Synthetic Spider Silk
Fibers Spun from Pyriform Spidroin 2, A Glue Silk Protein Discovered in Orb-Weaving Spider Attachment
Discs. Biomacromolecules 11(12):3495-3503.
12. Hsia Y, Gnesa E, Tang S, Jeffrey F, Geurts P, Zhao L, Fraz A, Vierra C. 2011. Identification and Synthesis
of Novel Biomaterials based on Spider Structural Silk Fibers. Applied Physics A: Materials Science and
Processing. 105(2): 301-309.
13. Gnesa E, Hsia Y, Yarger JL, Weber W, Lin-Cereghino J, Lin-Cereghino G, Tang SY, Agari K, Vierra C.
2012. Conserved C-Terminal Domain of Spider Tubuliform Spidroin 1 Contributes to Extensibility in
Synthetic Fibers. Biomacromolecules 2012(13): 304−312.
14. Ionova-Martin SS, Wade J, Tang SY, Shahnazarie M, Ager III JW, Lane NE, Alliston A, Vaisse C, Ritchie
RO. 2011. Changes in cortical bone response to high-fat diet from adolescence to adulthood in mice.
Osteoporosis International. 22: 2283–2293.
15. Tang SY, Souza RB, Ries M, Hansma PK, Alliston T, Li X. 2011. Local Tissue Properties of Human
Osteoarthritic Cartilage Correlate with T1Rho Relaxation Mapping Magnetic Resonance Imaging. Journal
of Orthopedic Research. 29(9):1312-9.
16. Zimmerman EA, Schaible E, Bale H, Barth HD, Tang SY, Reichert P, Busse B, Alliston T, Ager III JW,
Ritchie RO. 2011. Aging-related changes in the placitiy and toughness of human cortical bone at multiple
length-scales. Proceedings of the National Academy of Sciences. 108 (35):14416-14421.
17. Barth HD, Zimmerman EA, Schaible E, Tang SY, Alliston T, Ritchie RO. 2011. Characterization of the
effects of x-ray irradiation on the hierarchical structure and mechanical properties of human cortical bone.
Biomaterials 32 (34):8892-8904.
18. Jazini, E, Sharan AD, Morse LJ, Dyke JP, Aronowitz EA, Chen, L, Tang SY. 2012. Alterations in magnetic
resonance imaging T2 relaxation times of the ovine intervertebral disc due to non-enzymatic glycation.
Spine. Feb 15;37(4):E209-15
19. Tang SY, Herber RP, Ho S, Alliston T. 2012. Matrix Metalloproteinase-13 is Required for Osteocytic
Perilacunar Remodeling and Maintains Bone Fracture Resistance. Journal Bone Mineral Research. 27(9):
1-15.
20. *Nguyen J, *Tang SY, Nguyen D, Alliston T. 2012. Load regulates bone formation and Sclerostin
expression through a TGFb-dependent mechanism. Submitted to PLoS One. *Denotes equal contribution
authors.
21. Allen JL, Tang SY, Yurtsev EA, Hansma PK, Alliston T. Depth-Dependent Modulus of Articular Cartilage
Approaches Homogeneity with Osteoarthritis. Submitted to Journal of Biomechanics.
Selected Refereed Abstracts (Out of 47 Total)
1. Tang SY, Vashishth D. 2004. Micromechanical testing of individual trabeculae and small cortical bone
specimens. Trans Biomed Eng Soc. Philadelphia, PA.
2. Tang SY, Sharan AD, Novak EA, Ford TC, Vashishth D. 2005. Non-enzymatic glycation causes loss of
toughening mechanism in human cancellous bone. Trans Ortho Res Soc. Washington DC.
3. Tang SY, Berard GP, Alkalay RN, Vashishith D. 2005. Micromechanical multicyclic creep tests show
increased fragility of human cortical bone with age. Trans Ortho Res Soc. Washington DC.
4. Tang SY, Zeenath U, Vashishth D. 2005. The influence of non-enzymatic glycation on age-related decline
of bone quality in human cancellous bone. Trans Biomed Eng Soc. Baltimore, MD.
5. Tang SY and Vashishth D. 2006. A novel method for the examination and modeling of trabecular bone
microdamage. Proc Am Soc Mech Eng - Bioeng. Amelia Island, FL.
6. Tang SY, Tang RY, Vashishth D. 2006. Non-enzymatic glycation alters energy dissipation mechanisms in
cancellous bone. Trans Biomed Eng Soc. Chicago, IL.
7. Tang SY, Berard GP, Allen MR, Burr DB, Vashishth D. 2007. High-dose bisphosphonates treatment
increases the accumulation of advanced glycation end-products and explains the fragility of canine cortical
bone. Trans Ortho Res Soc. San Diego, CA.
8. Tang SY and Vashishth D. 2007. Nano-scale energy dissipation mechanisms in cancellous bone resist
fracture. Int Conf Mech Biomat Tissues. Kaua’i, HI.
9. Tang SY, Sharan AD, Vashishth D. 2008. The Loss of Water Content within the Intervertebral Disc
Through an Accumulation of Advanced Glycated Endproducts. Trans Ortho Res Soc. San Francisco, CA.
10. Tang SY and Vashishth D. 2008. A Three Dimensional Analysis And Segmentation Of Microdamage
Shows Compromised Microdamage Production Due To Nonenzymatic Glycation. Trans Ortho Res Soc.
San Francisco, CA.
11. Tang SY and Vashishth D. 2009. The Mechanistic Contributions of Nonenzymatic Glycation on Fracture
Toughness and R-Curve Behavior in Bone. Trans Ortho Res Soc. Las Vegas, NV.
12. Tang SY, Chen C, Nguyen DH, Chin EN, and Alliston T. 2009. MMP-13 may be Downstream of TGF-beta
to modulate the fracture resistance of bone. Trans Ortho Res Soc. Las Vegas, NV.
13. Tang SY and Alliston T. 2009. The Role of Proteoglycans in the Viscoelastic Behavior of Bovine Articular
Cartilage. UCSF Dental Research Symposium. San Francisco, CA.
14. Tang SY, Souza RB, Hansma PK, Alliston T, Li X. 2010. Local Tissue Properties of Human Osteoarthritic
Cartilage Correlate with T1rho Relaxation Mapping Magnetic Resonance Imaging. Trans Ortho Res Soc.
New Orleans, LA.
15. Tang SY, Jazini E, Arnowitz EB, Dyke JP, Sharan AD. 2010. Alterations in Magnetic Resonance Imaging
T2 Relaxation Times of the Intervertebral Disc Due to Non-enzymatic Glycation. Trans Ortho Res Soc.
New Orleans, LA.
16. Tang SY and Alliston T. 2010. Loss of Matrix Metalloproteinase-13 Increases Bone Fragility and Alters
Bone Matrix Material Properties. Trans Ortho Res Soc. New Orleans, LA.
17. Tang SY and Sharan AD. 2010. The Effects of Nonenzymatic Glycation on Invertebral Disc Material
Behavior and Tissue Hydration. World For Spin Res. Montreal, CA.
18. Tang SY, Hsia Y and Vierra C. 2010. The Nanostructure and Nanomechanics of a Black Widow Spider
Silk Assessed using Atomic Force Microscopy. Proc Am Soc Mech Eng - Bioeng. Naples, FL.
19. Tang SY and Vashishth D. 2010. The Multiscale Modeling of Bone Quality and Intracortical Porosity and
their Effects on Bone Fracture Resistance. Workshop on Sim Bone Tiss Clin App. Los Angeles, CA.
20. Sharan AD and Tang SY. 2010. The in vivo Noninvasive Imaging of the Molecular Level Changes in Disc
Degeneration. World For Spin Res. Montreal, CA.
21. Tang SY and Alliston T. 2010. Loss of Matrix Metalloproteinase-13 Increases Bone Matrix Heterogeneity
and Decreases Fracture Resistance. Proc Am Bone Mineral Res Society. Toronto, Canada.
22. Tang, SY, Souza RB, Hansma PK, Alliston, TN. 2011. The Targeted Cleavage of Proteoglycans Alters the
Viscoelastic Properties of Bovine Articular Cartilage. Trans Ortho Res Soc. Long Beach, CA.
23. Sharan AD, Tang, SY. 2011. The Effects Of Nonenzymatic Glycation On Invertebral Disc Tissue
Hydration and Material Behavior. Trans Ortho Res Soc. Long Beach, CA.
24. Morse LJ, Sharan AD, Souza RB, Tang, SY. 2011. The Differential Decline in the Elastic and Viscoelastic
Behavior within the Degenerating Intervertebral Disc. Trans Ortho Res Soc. Long Beach, CA.
25. Chen L, Sharan A, Tang SY. 2011. Induction and Cleavage of Fluroescent Non-enzymatic Glycation
Crosslinks in the Components of the Extracellular matrix. Trans Biomed Eng Soc. Hartford, CT.
26. Tang SY, Herber RP, Ho Sunita, Alliston, T. 2011. Matrix Metalloproteinase-13-mediated Cortical Bone
Remodeling Is Required for the Post-natal Maintenance of Bone Quality. Proc Am Bone Mineral Res
Society. San Diego, USA.
27. Nguyen J*, Tang SY*, Nguyen D, Alliston T. 2011. TGF-β-dependent Regulation of Sclerostin during
Mechanical Loading. Proc Am Bone Mineral Res Society. San Diego, USA. Equal contribution authors.
28. Morse LJ, Sharan A, Chen L, Tang SY. 2012. Changes in the Matrix Composition of the Degenerating
Human Intervertebral Disc and their Relative Influence Towards Annulus Fibrosus and Nucleus Pulposus
Tissue Mechanical Behavior. Trans Ortho Res Soc. San Francisco, CA.
29. Tang SY, Morse LJ, Chen L, Sharan A. 2012. A Novel Therapeutic for Rescuing the Adverse Effects of
Advanced Glycation End-products in the Intervertebral Disc. Trans Ortho Res Soc. San Francisco, CA.
30. Tang SY, Nguyen J, Alliston T. 2012. Load-induced Bone Formation Requires Sensitivity to TGF-β
Signaling. Trans Ortho Res Soc. San Francisco, CA.
31. Tang SY, Herber RP, Ho Sunita, Alliston, T. 2012. Optimal bone fracture resistance requires local
remodeling of cortical bone matrix through a matrix metalloproteinase-13-dependent mechanism. Trans
Ortho Res Soc. San Francisco, CA.
Ongoing Research Support
National Institute of Arthritis and Musculoskeletal and Skin
F32-059497
3/22/10-3/21/13
Role: PI
The Role of MMP-13 in the TGF-beta Regulation of Bone Matrix Material Properties
The research work proposed here aims to address the mechanisms of regulation of bone fracture resistance.
The increased understanding of the role of matrix metalloproteinase-13 in the TGF-beta regulation of bone
matrix material properties would allow the precise manipulation of the regulatory processes of healthy bone
maintenance. Furthermore, the results may lead to improved therapies and strategies for the prevention and
treatment of age-related and pathological bone fragility.
National Science Foundation- Division of Materials Research
DMR 1105310
7/01/11-6/30/14
Role: Co-PI. PI: Craig Vierra, Ph.D.
This proposal aims to elucidate the relationship between the molecular and mechanical properties of glue silks
will help delineate how glue silk protein sequences relate to its unique biological function, which will provide
insight into how these silk types are capable of being spun into a gelatinous matrix that facilitates spider
locomotion and web construction. Both natural and synthetic spider glue silk fibers will be characterized at the
nanoscale level to reveal the molecular relationship between the protein modules within the PySp1 amino acid
sequence and their contributions to the mechanical behavior of glue silks from black widow spiders.
National Institute of Aging
R43-060607
9/1/12-8/30/13
Role: Co-PI
PI: Paul Hansma, Ph.D.
This current proposal examines the feasibility and the overall systematic predictive capability of a new
instrumental for the clinical diagnostic of fracture assessment by direct and minimally invasive indentation.