Gel Formation Bressanone Sept. 2006 Gel Formation 1 Outline Sol-Gel Processing Chart Gel Sol Solvent Evaporation Powders Supercritical Extraction Gelation Evaporation Xerogel Xerogel Film Aerogel Dry Heat Heat Dense Ceramic Film Bressanone Sept. 2006 Dense Glass Gel Formation 2 1 Outline Silica-Based Gels hydrolysis and condensation gelation network vs. cluster formation two-component systems Metal Oxide-Based Gels difference between Si(OR)4 and M(OR)n network vs. cluster formation Non-hydrolytic Sol-Gel Processes Bressanone Sept. 2006 Gel Formation 3 Hydrolysis and Condensation of Silicon Compounds Generation of reactive species: hydrolysis ≡Si-OR + H2O ≡Si-OH + ROH Network formation: condensation 2 ≡Si-OH ≡Si-O-Si≡ + H2O ≡Si-OH + RO-Si≡ Note: ≡Si-O-Si≡ + ROH • • • • • • • • Kind of catalyst (pH) Kind of molecular precursor Water:OR-ratio (Rw) Solvent Temperature Additives (e.g. electrolytes, surfactants, complexing agents) Absolute concentration of the precursors Relative concentration of the precursors in multi-component systems colloidal silica dispersions (water glass “solutions”) already contain Si-OH species Bressanone Sept. 2006 Gel Formation 4 2 Reaction Parameters: Catalyst Acidic conditions: Si OX + H+ Si O+ H X Y−OH + Si O+ H Y−O −Si + HOX + H+ X Alkaline conditions (similar F-): OY Si-OX + YO− − Si YO- Si + XO- OX hydrolysis reaction: X = R, condensation reaction: X = R or H, Y = Si alcohol exchange: X = R, Bressanone Sept. 2006 Y=H Y = R' Gel Formation 5 Electrostatic Stabilization of Colloids M-O- + H M-OH M O H Point of zero charge (PZC): for SiO2 ≈1.5 – 4.5 Gelation by pH change Bressanone Sept. 2006 Gel Formation 6 3 pH Dependence of Hydrolysis and Condensation Bressanone Sept. 2006 Gel Formation 7 Geland Formation: Sol-Gelof Processing Hydrolysis Condensation Silicon Alkoxides OR Si RO RO OR H2 O cat. Hydrolysis Si OH OR OH RO RO Si RO RO OH OR HO HO OH Si OH RO RO Si O OH OR Si Si OR OR O OR OR Si hydrolysis and condensation occur concomitantly ! Condensation OR RO RO RO O OR OR RO RO RO RO OR Si Si O OR OR OR OR Si Si O OR OR Si RO RO OH Si OR Si RO O OR Si OR OR O Si OR OR O OH HO HO Si OR OR OH RO RO OH O O O RO RO Si Si O Si OR Si OR OR RO RO O RO O RO RO HO Si OR Si Si O Si RO OR OR O OR RO Si Si O OH RO Si OR OR ORO Si O RO Si OROR Bressanone Sept. 2006 Gel Formation 8 4 Reaction Parameters: Influence of the Substituents Steric and electronic influence of the OR group: Si(OMe)4 > Si(OEt)4 > Si(OnPr)4 > Si(OiPr)4 Reaction rate Electronic influence of organic substituents: ≡Si−R > ≡Si−OR > ≡Si−OH > ≡Si−O−Si≡ Electron density at silicon ⇒ acid catalysis: base catalysis: reaction rates decrease from left to right reaction rates increase from left to right Influence of the (CH2)n chain length (RO)3SiCH2OC(O)C(Me)C=CH2 reacts ~60 times faster than (RO)3Si(CH2)3OC(O)C(Me)C=CH2 Bressanone Sept. 2006 Gel Formation 9 Reaction Parameters: Influence of the Substituents Electrophilicity of silicon Consequences (I) Reactivity in acidic medium Si OR Si RO OR > < Si RO OR OR OR > < OR Si RO OH OH Si RO OR OR OH Si > < OR OH RO O OH OH > < Si RO OR OH OH > < Si HO OH OH Reactivity in basic medium Bressanone Sept. 2006 Gel Formation 10 5 Reaction Parameters: Influence of the Substituents Consequences (II) Acidity of Si-OH groups highest lowest OH HO Si OR O RO Si O OH Si O Si O O O HO Si O OR O Si OH O O O NB: this is one of the reasons why the PZC changes with the degree of condensation. Bressanone Sept. 2006 Gel Formation 11 Formation: Growth Models pHGel Influence on Network Structure Si Consequences (IIIa) OX + H+ Si H X X = R, H Y−OH + O+ Si O+ Si H Y−O −Si + HOX X Acidic conditions: Reaction at the least condensed Si atom OH HO Si RO Si O O O Si Si O O HO Condensation reaction proceeds preferentially at terminal Si-atoms OR O Si OH O O OH OR Si O O Polymeric network O Bressanone Sept. 2006 Gel Formation 12 6 Formation: Growth Models pHGel Influence on Network Structure Consequences (IIIb) OY Si-OX + YO− Y = H, − Si Si YO- Si + XO- OX Alkaline conditions: Nucleophilic attack at the most condensed Si atoms OH HO Si O RO Si O O O Si Si O O HO Condensation reaction proceeds preferentially at central Si-atoms OR Si OH O O OH OR Si O O O Colloidal network Bressanone Sept. 2006 Gel Formation 13 GelInfluence Formation: Processing pH onSol-Gel Network Structure Monomer Dimer Cyclic Particle Acidic conditions Basic conditions 1 nm 5 nm 10 nm 30 nm 100 nm Three-dimensional gel networks Bressanone Sept. 2006 Sols Gel Formation 14 7 Gel Formation: Processing StöberSol-Gel Process O EtOH H2O NH3 O Si O O or O O Si O O Hydrolysis/ Condensation EtOH Monodisperse particles MeOH Monodisperse silica spheres (diameter of about 0.2 μm) Bressanone Sept. 2006 Gel Formation 15 Reaction Parameters: Influence of the Substituents Consequences (IV) From 29Si NMR (ethanolic solutions, H2O/OEt = 1, pH = 2) The order is reverse in base-catalyzed systems Bressanone Sept. 2006 Gel Formation 16 8 Other Important Reaction Parameters The alkoxy group / H2O ratio (Rw) Theoretically Rw = 2 for Rw = 1 for Si(OR)4 → SiO2 Si(OR)4 → Si(OH)4 (without condensation) In practice • lower Rw (more water) favors the formation of Si-OH over Si−O−Si • even with Rw >2 only mixtures of [SiOx(OH)y(OR)z]n (2x+y+z = 4) are obtained The solvent • • Homogenization of the reaction mixture Polar and especially protic solvents stabilize polar species such as [Si(OR)x(OH)y]n Bressanone Sept. 2006 Gel Formation 17 Outline Silica-Based Gels hydrolysis and condensation gelation network vs. cluster formation two-component systems Metal Oxide-Based Gels difference between Si(OR)4 and M(OR)n network vs. cluster formation Non-hydrolytic Sol-Gel Processes Bressanone Sept. 2006 Gel Formation 18 9 Gelation Particle Acidic conditions Basic conditions 1 nm 5 nm 10 nm 30 nm 100 nm Three-dimensional gel networks Sols HO HO OH OH Si O HO HO O O Si O Si O O Si HO Si Si O OH Si O O OH Si O HO Si O Si Si O O O O Si O Si O HO Si Si O O O HO Si O O Si OH HO OH Bressanone Sept. 2006 OH Gel Formation 19 Site Percolation on a Square Lattice p = fraction of filled spheres s = cluster size Bressanone Sept. 2006 Gel Formation 20 10 Gel Kinetic Formation: Growth Models Growth Models Ballistic Diffusion-limited Cluster-Cluster Monomer-Cluster Reaction-limited Bressanone Sept. 2006 Gel Formation 21 Gelation is not a Thermodynamic Event viscosity Viskosität Konzentration Si-O-Si Si–O–Si concentration Gelpunkt gel point Bressanone Sept. 2006 Gel Formation Zeit time 22 11 Consequences of Introducing Organic Substituents • Reduced degree of crosslinking of the inorganic network • Polarity changes (changes in hydrogen bonding) • Reactivity change of the remaining alkoxide groups (electronic and steric effect of the organic substituents) These effects are an inevitable consequence of the organic modification Bressanone Sept. 2006 Gel Formation 23 Outline Silica-Based Gels hydrolysis and condensation gelation network vs. cluster formation two-component systems Metal Oxide-Based Gels difference between Si(OR)4 and M(OR)n network vs. cluster formation Non-hydrolytic Sol-Gel Processes Bressanone Sept. 2006 Gel Formation 24 12 Silsesquioxanes (X = R) and Spherosilicates (X = O-) Si(OR)4 + H2O (NR4OH) ⎯→ [SinO2.5n]nRSiX3 (X = Cl, OR') + H2O (organic solvent) ⎯→ RnSinO1.5n X X X O X O O X Si O O Si Si X X Si Si O O Si Si X Si O O Si X Si Si Si O X O O Si X X Si X O O Si Si X OO Si O Si O O O X X Si X X Bressanone Sept. 2006 Si Si OO O Si X X O O Si O X O O X X Si O O O O X O O O O Gel Formation 25 Modification of Spherosilicates (X = O-) - O- O Si - O Si O O -O O Si O O Si O Si O O Si - O Si - O O Si Si O Si O O O O Si Si O O O O O- O- O + ClSiMe2(CH2CH=CH2) O O Si + ClSiHMe2 Si Si O O Si Si O Si O Si 8 Si O O O Si Si O O O Si O O Si O Si Bressanone Sept. 2006 O O O +8 Si H 8 Si O Si O Si O O O Si Si O O O O Si O R O O Si Si O O 8 Si Gel Formation 26 13 Modification of Silsesquioxanes Si O Si O O O O Si O Si Si O Si O O O Si O Si HNO3 8 Si O Si O O O O Si O Si Si O Si O O O Si O Si Pd/C NO2 8 Si O Si O O O O O Si Si O Si O O O Si O Si Si NH2 8 Si O Si O O O O O Si Si O Si O O O Si O Si Si Si OH OH + CH2=CHCH2SiCl3 O OH O O Si Si O Si O O O Si O Si Si + metal compounds Bressanone Sept. 2006 Si O MLn O O O O Si O Si Si O Si O O O Si O Si Gel Formation 27 Gel Permeation Chromatography on Hydrolyzed R‘Si(OR)3 Hydrolysis of (RO)3Si O (Rw = 1.5; no catalyst) O Bressanone Sept. 2006 Gel Formation 28 14 Gel Permeation Chromatography on Hydrolyzed R‘Si(OR)3 Hydrolysis of (RO)3Si O (Rw = 1.5) O Bressanone Sept. 2006 Gel Formation 29 Outline Silica-Based Gels hydrolysis and condensation gelation network vs. cluster formation two-component systems Metal Oxide-Based Gels difference between Si(OR)4 and M(OR)n network vs. cluster formation Non-hydrolytic Sol-Gel Processes Bressanone Sept. 2006 Gel Formation 30 15 Two-Component Systems For example: • Alkoxides of different metals (Si(OR)4 and Ti(OR)4) • Substituted and unsubstituted alkoxides (Si(OR)4 and R’Si(OR)3) Problem: Different hydolysis / condensation rates ⇒ phase separations Possible solutions • Pre-hydrolysis of faster reacting component • Moderation of the reactivity of the faster reacting component • Single-source precursours Bressanone Sept. 2006 Gel Formation 31 Gel Two-Component Formation: Sol-GelSystems Processing H2O base catalyst SiO2 CH3Si(OCH3)3 + Si(OCH3)4 (1:4) in NH4OH Bressanone Sept. 2006 Gel Formation 32 16 Two-Component Systems first stage O Ti(O Pr)3 A O A BB A BO B A A BB A A A A A A A BB BO B A B B B B A BO B A BB A A A A A BB BO B BB A i Bressanone Sept. 2006 A A (MeO)3Si A Gel Formation 33 Outline Silica-Based Gels hydrolysis and condensation gelation network vs. cluster formation two-component systems Metal Oxide-Based Gels difference between Si(OR)4 and M(OR)n network vs. cluster formation Non-hydrolytic Sol-Gel Processes Bressanone Sept. 2006 Gel Formation 34 17 Comparison of Reactivity of M(OR)x and Si(OR)4 Si(OiPr)4 <<< Sn(OiPr)4, Ti(OiPr)4 < Zr(OiPr)4 < Ce(OiPr)4 1. Metal alkoxides are stronger Lewis acids than silicon alkoxides ⇒ Nucleophilic attack is facilitated ⇒ strong increase of the hydrolysis rates. Hydrolysis rate of Ti(OR)4 ≈ 105 times faster than that of Si(OR)4. 2. The preferred coordination number of metals is higher than their valency Most metals have several stable coordination numbers, or the expansion of the coordination sphere in transition states is easier. ! Sol-gel processing of metal alkoxides does not require a catalyst Moderation of the reactivity of metal alkoxides “Chemical additives” = replacement of one or more OR ligands by groups which are less easily hydrolyzed and additionally block coordination sites at the metal. Bressanone Sept. 2006 Gel Formation 35 Gelation of Metal Alkoxide Systems Gelification diagrams of Zr(OPr)4 top: acetylacetone bottom: ethyl acetoacetate O O O + Zr(OPr) 4 R Zr(OPr) O 4-n n R = CH 3, OCH 2 CH 3 Bressanone Sept. 2006 Gel Formation 36 18 Gels from Metal Compounds: Role of the Counter-Ion Strong metal-anion interactions (anion coordination) may influence sol– gel processing • The hydrolysis and condensation reactions may proceed differently when different salts of the same metal are employed. • Strong coordination of a counter-ion blocks coordination sites and leads to a smaller degree of condensation (fewer M−O−M links per metal atom can be formed). • The counterions may (partially) stay in the material. Their (complete) removal may be difficult and may require special post-synthesis procedures. • Coordinated counter-ions can direct the site of nucleophilic attack (cis or trans to the coordinated X, for example) during hydrolysis and condensation ⇒ influence on the microstructure and morphology of the gels or precipitates. • Non-coordinated counterions may influence the electrostatic double layer of the sol particles and hence their aggregation. Bressanone Sept. 2006 Gel Formation 37 Polycations and Polyanions Examples: [V10O28]6- [M13O4(OH)24(H2O)12]7+ (M = Al, Ga, Fe) “Al13” [H2W12O42]10- Bressanone Sept. 2006 Gel Formation [Al13]2[Al4(OH)8(H2O)6]18+ 38 19 Carboxylate-Substituted Metal Oxide Clusters Ta4O4(OEt)8(OMc)4 * Ti2Zr6O6(OMc)20 Ti2HfZr5O6(OMc)20 M6(OH)4O4(OMc)12 (M = Zr, Hf) Ti4Y2O4(OMc)14(HOCH2CHOMe)2 Ti6O4(OEt)8(OMc)8 Ti4Zr2O4(OBu)6(OMc)10 [Zr6(OH)4O4(OAcr)12]2 OMc = methacrylate Bressanone Sept. 2006 Gel Formation 39 Outline Silica-Based Gels hydrolysis and condensation gelation network vs. cluster formation two-component systems Metal Oxide-Based Gels difference between Si(OR)4 and M(OR)n network vs. cluster formation Non-hydrolytic Sol-Gel Processes Bressanone Sept. 2006 Gel Formation 40 20 Non-hydrolytic sol-gel processing Non-Hydrolytic Sol-Gel Processes Reaction of a metal halide or semi-metal halide with a metal alkoxide under non-aqueous conditions to form an inorganic oxide M O R M OR + M X M O M + R X M X Exchange M X + M OR X = Cl, acetate The metal alkoxide may be generated by reaction of the metal halide with an ether or an alcohol) Bressanone Sept. 2006 Gel Formation 41 Non-hydrolytic sol-gel processing Non-Hydrolytic Sol-Gel Processes: Example I Titania-Silica Gels TiCl4 + Si(OiPr)4 ⎯→ SiO2/TiO2 + iPrCl Ti(OiPr)4 + SiCl4 ⎯→ SiO2/TiO2 + iPrCl Ti(OiPr)4 + Si(OOCCH3)4 ⎯→ SiO2/TiO2 + CH3COOiPr TiCl4 + SiCl4 + iPr2O ⎯→ SiO2/TiO2 + iPrCl ( ≡M-Cl + R-O-R ⎯→ ≡M-OR + RCl) Bressanone Sept. 2006 Gel Formation 42 21 Non-hydrolytic sol-gel processing Non-Hydrolytic Sol-Gel Processes: Example II Organically Modified Silicas Cl CH3 H3C Si Cl + HO C CH3 Cl CH3 Cl CH3 H3C Si O C CH3 + HCl Cl CH3 Cl Cl CH3 CH3 H3C Si O Si O C CH3 + Cl C CH3 CH3 Cl CH3 CH3 CH3 CH3 Cl CH3 H3C Si O C CH3 + Cl Si O C CH3 Cl CH3 Cl CH3 Cl Cl CH3 H3C Si O Si CH3 + Cl C CH3 Cl CH3 Cl H3C Cl Cl H3C Si Cl + H3C C O Si CH3 H3C Cl Cl Alkyl-silicon bonds are stable under non-hydrolytic conditions! Bressanone Sept. 2006 Gel Formation 43 Non-hydrolytic sol-gel processingSol-Gel Processes Comparison of Hydrolytic and Non-Hydrolytic Hydrolytic Non-hydrolytic Facile, low-temperature process Facile, low-temperature process Homogenizing solvent may be necessary Potentially solvent free Use of water Reactive reagents (inert-gas synthesis) Water, alcohol are formed during the reactions Alkyl halides are formed Good for ionic and O-containing species Potential problems with Ocontaining species Limited compatibility of hydrophobic species Potentially phase separation in two-component systems No problem with hydrophobic components No phase separation Well-established New technology, good for watersensitive species Bressanone Sept. 2006 Gel Formation 44 22 Non-hydrolytic sol-gel processing Non-Hydrolytic Sol-Gel Processes Silsesquicarbodiimides n MeSiCl3 + 1.5n Me3Si-N=C=N-SiMe3 pyridine [MeSi(N=C=N)1.5]n + 3n Me3SiCl Gel Substitution MeSiCl3 + Me3Si-N=C=N-SiMe3 MeCl2Si-N=C=N-SiMe3 + Me3SiCl Condensation MeCl2Si-N=C=N-SiMe3 + Cl Si MeCl2Si-N=C=N-SiMe3 Bressanone Sept. 2006 MeCl2Si-N=C=N-Si + Me3SiCl MeCl2Si-N=C=N-SiCl2Me + Me3Si-N=C=N-SiMe3 Gel Formation 45 Special Case: Formic Acid Route Very rapid („schnell gels“) ! Bressanone Sept. 2006 Gel Formation 46 23