Vitamin K 1. What is the nutrient? Vitamin K 2. What is the RDA/DRI for the nutrient? The FOB at the IOM recommends the following: Life Stage Infants Infants Children Children Children Adolescents Adults Pregnancy Pregnancy Breast-feeding Breast-feeding AI for Vitamin K Age Males (mcg/day) 0-6 months 2 7-12 months 2.5 1-3 years 30 4-8 years 55 9-13 years 660 14-18 75 19 years and older 120 18 years and younger 19 years and older 18 years and younger 19 years and older - Females (mcg/day) 2 2.5 30 55 60 75 90 75 90 75 90 3. How is the nutrient metabolized? Vitamin K is a fat-soluble vitamin that requires bile salts in order for it to be absorbed into the small intestines. Typical absorption rates are around 80%. Most absorption occurs in the terminal ileum. 4. What are food sources of the nutrient? Olive oil, soybean oil, canola oil, mayonnaise, broccoli, kale, spinach, green leaf lettuce, Chard, watercress, parsley. It is also synthesized by the large intestine. 5. What disease states alter the nutrients metabolism? Liver disease in which there is a decrease in bile salts can lead to altered Vitamin K Metabolism, also diseases of the small intestine could affected Vitamin K absorption. 6. What are the tests or procedures to assess the nutrient level in the body? Prothrombin time measures the amount of time required for blood to clot properly, a delayed clotting time can indicate a deficiency. 7. What is the drug –nutrient interactions? Vitamin K is known to interfere with blood thinners and anticoagulants, such as warfarin. 8. How is the nutrient measured? It is measured in micrograms. 9. What is the Upper Tolerable Limits? There is no known toxicity. 10.What are the physical signs of deficiency? Impaired blood clotting, bruising, bleeding, nosebleeds, bleeding gums, blood in the urine and stool, heavy menstrual periods. 11.What are physical signs of toxicity? N/A http://www.fao.org/DOCREP/004/Y2809E/y2809e0g.htm http://www.vivo.colostate.edu/hbooks/pathphys/misc_topics/vitamink.html http://lpi.oregonstate.edu/infocenter/vitamins/vitaminK/ http://www.nlm.nih.gov/medlineplus/ency/article/002407.htm