Why Meiosis? The purpose of meiosis is to reduce the chromosome number so that parents can reproduce unique offspring--chromosomal number of offspring would double with each generation without meiosis! Why Meiosis? Which species has 92 chromosomes? Aquatic rats 13-2 Basics Gametes -½ the genetic material as somatic cells and are genetically unique. Haploid is term for ½ set of genes. Examples are sperm and egg. (Not somatic body cells) New offspring formed after sexual reproduction (fertilization). Sperm + egg = zygote Basics The goals/purpose of meiosis are two-fold 1) to create diversity and 2) to reduce the number of total chromosomes in the cell to ½ that of the parent cell. Large numbers of people remained healthy during an Ebola outbreak and showed antibody resistance to the virus. 71% percent of individuals with positive Ebola antibody tests had not gotten sick; in another, 46 % remained healthy despite testing positive for Ebola antibodies (Huffington post 10/2014 & picture from NPR) Basics Some organisms (bacteria and yeast) go through a type of mitotic reproduction called binary fission. Some organisms only contain one gender and reproduce asexually so there is less genetic variation in female populations (examples include some lizard species and fish). For instance, desert whiptails do not have male genders and meiosis is limited in its ability to diversify genes before egg laying. Check your understanding What is the difference between haploid and diploid? What is a somatic cell? What is a zygote? What are the 2 main goals and advantages of meiosis and sexual reproduction? A. *DNA synthesis —all cells have 2 x the DNA (enough for 92 chromosomes). B. Meiosis phases are very similar to mitosis (PMAT) with a few exceptions: 1) -Prophase 1 of meiosis: a) 2 copied chromosomes come in contact with each other. They form a structure called a tetrad. Prophase 1 and Crossing Over b) Homologous pairs of chromosomes physically touch c) Crossing over is the exchange and recombination of genes (pieces of DNA) from one chromosome to the other. http://highered.mheduc ation.com/sites/98340 92339/student_view0/c hapter11/meiosis_with_ crossing_over.html Crossing over during meiosis: With exchange of genetic information, the DNA sequence is changed in each chromosome. Genetic recombination during crossing over leads to more genetic diversity and the possibility of new traits. Haploid formation Meiosis I 2---(PMAT) At the end of meiosis 1 there are 46 unique haploid chromosomes (copied) in each cell and the homologous pairs have been independently separated—each genetically unique new cell contains 23x2 and 23x2 . 1/25/2016 11 Haploid Gamete formation: Meiosis II Meiosis II-another cell division that results in 4 haploid cells with only 23 chromosomes in each. 1/25/2016 12 Meiosis II Notice the haploid cells separated from homologous pairs at the beginning (P1) Review and practice: http://www.phschool.com/science/biology_pl ace/biocoach/meiosis/overview.html Haploid Gamete formation Polar Bodies In males, all 4 haploid cells become sperm In females, only 1 of the haploid cells become an egg. That one egg takes all of the cytoplasm and organelles from the other 3 cells. Polar body is the term for each of the other 3 cells produced as waste and reabsorbed by the female. Why do 3 of the haploid cells produced in female meiosis not make it to maturity?? Egg cell/ovum “polar body” Revisit Earlier question Which stage of meiosis accomplishes each of the 2 goals? Meiosis 1 = Genetic Diversity Meiosis 2 = Reduce chromosome number Similarities 1. 2. 3. 4. 5. 6. Types of cell division Occur in humans and other Eukaryotes Involve parent cells with 46 chromosomes Produce new daughter cells Cytokinesis PMAT sequence is the same in mitosis and meiosis II Differences between meiosis and mitosis 1. Prophase of meiosis I creates genetic diversity/recombination. Mitosis doesn’t create diversity-only cloned cells. 2. What are the only cells in the mammal body that undergo meiosis? Why? http://www.youtube.com/watch?v=qCLmR9YY7o&edufilter=cILBN4dlLF7R2bE8S5GdlA&safe=acti ve Which picture (left or right) represents meiosis and which represents mitosis? How can you tell? Compare Mitosis and Meiosis http://highered.mheducation.com/sites/9834092339/student_v iew0/chapter11/comparison_of_meiosis_and_mitosis.html DIFFERENCES: Mitosis # of times through the stages: # of daughter cells produced: Chromosome number in daughter cells: Chromosome number in parent cell: Purpose: Meiosis 1 2 2 4 46 23 46 46 Growth and repair Gamete production (sexual reproduction) Meiosis vs Mitosis Visual Summary This diagram is courtesy of Stacy Zimmermann of Rutgers University. Quiz yourself by using your fingers—1 for haploid, 2 for diploid etc.