USC CHEMIST A Newsletter for Alumni and Friends of the Department Department of Chemistry and Biochemistry University of South Carolina Fall 2001 Looking Back— Guy Fleming Lipscomb, BS 1938 Having enjoyed the article on Dr. Guy White, 1929, I could not help thinking about my days as the son of a department head, Dr. Guy F. Lipscomb. My first exposure to the Chemistry Department was as a child Lipscomb living on the campus. I remember Dr. William Burney, chemistry head, as a warm, friendly man who was kind to me as a young boy. Dr. Burney brought my father from Clemson to USC in 1919. Dr. Mills joined the department in the 20’s and left in the 30’s to develop the research department at Sonoco Products in Hartsville—later, Mills had Dr. Copenhaver, of the USC chemistry department, join him in Hartsville. Entering the University in 1934, having listened to chemistry over the dining table for years, it was almost a foregone conclusion that I would be a student in my father’s freshman chemistry class. One thing I soon realized was that we would have a quiz every Monday morning! And he would let us drop one score during the semester for our final quiz score. He also would let us skip the exam if we had a 95 Please see Lipscomb on page 10 You Can Help! Help perpetuate the department’s tradition of producing outstanding chemistry students by making a donation to one of our scholarship, fellowship, or lectureship funds. See the enclosed envelope for more information. Thank you! The New Graduate Science Research Center Department Moves Into the GSRC At long last, after literally years of waiting, faculty, staff and students are occupying the new Graduate Science Research Center (GSRC). Although certain cynics jokingly quipped that we’d never see the day when the building was complete, the Department of Chemistry and Biochemistry began its laborious move in April 2000. In the process of transporting equipment, files and personal belongings from the Jones Physical Sciences Center (PSC, the “old” Chemistry building) across Devine Street to the new GSRC, the predominating feeling was perhaps disbelief! “In truth,” says Dr. Roy Wuthier, “I never thought I would live to see the day when I was actually working in a new building. We should be very glad to be here!” As is always the case, the move was stressful, and there were inevitable losses. Certain chemistry and biochemistry staff members lament the disorganization of their files, which were slowly but surely sorted out before the beginning of our first term in the new building. And, because of the nature of the department’s lab equipment (fragile and expensive!), the move was especially trying. “After working in the old building for almost my entire graduate career, I was none too eager to move, even to a new state-of-the-art facility,” says graduate student Andrea Thomas. “Moving an office, much less a fully-stocked chemistry lab is no one’s idea of a good time.” But all worked out for the best— “We found that teamwork and planning saved the day. A lot got cleaned out, thrown out, and, just like cleaning out your closet, we found things we forgot we even had. Now it seems like we’ve always been here!” But none of the stresses of moving could possibly interfere with the elation of the faculty and students who have the privilege of christening the brand-new, state-of-the-art labs with their research! “The new building is beautiful!” says Ms. Thomas. “The hoods are fantastic, our laser room is well-designed and perfectly functional, and the wet lab is a pleasure to work in. We have a lot to be grateful for in the GSRC.” The space available for departmental research has been increased 75 percent in our new building. Productivity is increased through modern design—the building was designed as a chemistry research building and features a futuristic Please see GSRC on page 5 Alumnus Reveals Secret to Stock Market Success One of the University of South Carolina’s most generous donors and friends, Dr. Fred Weissman (BS, Chemistry, ’36), has published his first book, In Bed with the Right People: How I Made Millions on Wall Street. Fred Weissman should be a familiar name to any friend of USC. His dedication to the University and his fascinating life make Weissman a remarkable individual. During World War II he served the U.S. Army flying C47s in North Africa, Sicily, and England. He was later assigned to a U.S. Army Air Forces Intelligence Operation in Germany under the direct auspices of the war department, where he served with distinction. After studying medicine at the University of Geneva Medical School, Weissman worked his internship at the City Hospital in New York, completing his residency in neurology at Bellevue. Weissman held a private neurological practice, and was a member of the staff of the New York Medical College. He is also a longtime supporter of the department and the University, both financially and by example. In 1989, Dr. Weissman provided $100,000 to establish a chaired professorship in chemical ecology within the Department of Chemistry and Biochemistry. He has also funded an endowment for faculty enrichment in the College of Liberal Arts, and in 1992 established the David and Esther Berlinberg Distinguished Professorship in the College of Business. In addition, Weissman has served on the USC Educational Foundation Board’s Investment Committee for a number of years. Dr. Weissman’s academic and philanthropic successes are themselves testaments to the strength of a USC education. Weissman’s book is a detailed account of one of his less celebrated successes: his career in the stock market. It outlines the guiding principles and methodologies that have led him to a prominent position in the world of trading. A fascinating story, Dr. Weissman’s book is an intricate recollection of every step of his financial career. He reflects with insight both into the psychological experience of the stock trader and into the stock market itself. Although his modesty insists upon stressing the errors he made during his 40 years of trading, Dr. Weissman’s patience, perseverance, and appreciation of those who came before him culminated in an astounding success in the market. This book is the story of the transformation of a young dabbler in the stock market into a confident and seasoned expert. What is perhaps most remarkable about this book, beyond Weissman’s amazing foresight into the stock market, is that he wrote In Bed With the Right People not out of a desire to promulgate or aggrandize his financial success, but so that he might share his insight—true to his philanthropic nature. This book is intended to prevent those who read it from making the mistakes Dr. Weissman did early on; to reinforce the lessons which Weissman was forced to learn the hard way—through loss of both money and confidence. He encourages the reader to follow their reasoning faculties, but he also stresses the importance of listening to one’s intuition. The title of Weissman’s book derives from his belief that one of the wisest paths for anyone who “plays” the stock market is to learn how the experts, the successful traders, earned their positions, and to follow their example. One per2 son whose life is an example to Dr. Weissman is George Soros, founder of the Open Society Fund and the Central European University. Weissman stresses the influence of Soros’ concept of “reflexivity” on his methods of trading stock. As Weissman writes, “His is a prescription for thinking and acting upon problems encountered in all walks of life, not just investment.” The idea has been crucial to Weissman’s success, and is a theme in his book. He explains the theory in his own words in the introduction to In Bed with the Right People: “ … knowledge is always less than perfect, hence the state of human knowledge about a company’s potential, or for that matter a society’s circumstances, always diverges from reality. The greater the divergence, the greater the chance of a dramatic shift.” This leaves a wide gap of potential influence on reality. “ … human action influences reality, and the greater the divergence between our knowledge and reality, the greater the potential for influence.” By our very interactions with reality, we alter reality itself. When we choose to invest in a particular stock because of its upward mobility, our investment influences and alters that mobility. “ … relation between knowledge and reality is reflexive, hence the name of his paradigm … analysts assess value, value in turn is altered due to the source of the assessment, which in turn modifies the assessment and so on.” Dr. Weissman describes in his book how he has utilized the idea of reflexivity in order to make certain crucial decisions in stock trading: What does one do when a stock bought months ago is going anywhere but up, but had been showing so much promise? Should a person sell stock in a company that hasn’t gone up in two years, but hasn’t gone down, either? What risks should a novice be willing to take? Using Soros’ idea of reflexivity and other lessons learned from his predecessors, Dr. Weissman offers worldly answers to these questions and more, and creates for his readers a how-to manual for the stock market. Once again, Dr. Fred Weissman has served the USC community well through his insightful and interesting book. We applaud another success! Department of Chemistry and Biochemistry Salutes Retirees Last year, the Department of Chemistry and Biochemistry said goodbye to four important members of its community. Commencement ceremonies in May 2000 and May 2001 Gimarc marked the retirements of faculty members Daniel J. Antion and Benjamin M. Gimarc, and long-time staff members Joel M. Babbitt and Georgia Lloyd. The warm and tearful reaction from the departmental community to these retirements is a testament to the effect these four people have had on the department. Dr. Gimarc has been with USC since 1966. He earned a BS in Chemistry from Rice University, served in the United States Navy from 1956–58, and was awarded a Ph.D. from Northwestern University where he received a Union Carbide Fellowship. After completing a postdoctoral at Johns Hopkins University, Dr. Gimarc came to the University of South Carolina. Once at USC, he embarked on a varied and assiduous career. He served on the Faculty Senate, as an undergraduate advisor, as a medical technology advisor, as a Fulbright program advisor, and untiringly carried out other committee work. Dr. Gimarc served as both chair and department head of the DepartAntion ment of Chemistry and Biochemistry. He held visiting appointments at Rudjer Boskovic Institute in Zagreb, Yugoslavia, Princeton University, and the University of California-Berkeley. Dr. Gimarc published over 70 articles in the most prestigious academic journals throughout his career and wrote a book, Molecular Structure and Bonding: The Qualitative Molecular Orbital Approach, published by the Academic Press. Upon his retirement, Dr. Gimarc became a distinguished professor emeritus at USC. At the reception in his and Dr. Antion’s honor, Dr. Gimarc indicated that he is at work on another book that will stand as the second volume to his previously published book. Dr. Antion’s association with USC started just three years after Dr. Gimarc joined the University. He received a Ph.D. from the Department of Chemistry and Biochemistry at USC in 1969. He followed his Ph.D. by working as a research chemist at Carnegie-Mellon University and then at E.I. duPont de Nemours & Co. Dr. Antion returned to USC in 1973 after a stint teaching chemistry at Stanly Community College in Albemarle, North Carolina. Upon arriving at USC, Dr. Antion was appointed assistant dean of the College of Science and Mathematics and also taught chemistry for the Department of Chemistry and Biochemistry. Since that time Dr. Antion has served the administration admirably, holding positions of associate provost, associate director of the Office of Technology Transfer, and director of outreach activities. Dr. Antion also served as the chair of the South Carolina section of the American Chemical Society, as president of the South Carolina Academy of Science, and received the Governor’s Award for Excellence in Science in 1995. Our two retiring staff members were both well-loved people and dedicated workers whose skill and service will be missed. Joel Babbit, our master glass blower, received his training from the University of Michigan. He began his career working at Ann Arbor Scientific, Inc., in Ann Arbor, Michigan, where he provided glass blowing services to dozens of public and private organizations, including General Motors and N.A.S.A. Later, he became the manager of the glass blowing shop at the University of Michigan, where he worked for four years. In 1983, Babbit Babbitt began his 3 work at the University of South Carolina, and he has been with us since. As master glass blower, Babbitt not only repaired containers or other lab equipment made of glass; he also designed and constructed glassware especially made to fit a particular research need. For instance, he assisted a number of faculty in building vacuum lines so that they could conduct chemical experiments in the absence of oxygen and other gases or in the presence of a defined gas or mixture of gases. Thus, he played a very significant role in the department; the absence of a glass blower from the staff will be felt by the faculty. Georgia Lloyd, coordinator for the faculty director of medical biochemistry, received a bachelor’s degree in biology from the University of North Carolina, and is a registered medical technologist. During her tenure with us, Lloyd worked closely with Dr. Roy Wuthier, then Dr. John Baynes, and finally with Dr. Jim Sodetz. Her primary duties were to organize the twosemester course syllabus, arrange for the staffing of Lloyd Clinical Correlation Conferences by physicians, proctor and grade quizzes and exams for at least 72 first-year medical students, and compile and report the performance of each student. Former chair Dr. Bruce Dunlap says, “Georgia’s industriousness and reliability greatly lightened the load for the biochemists in the department.” The University and the Department of Chemistry and Biochemistry are eminently grateful to these four community members for their service to the University, and to the department. Though they will be missed, we are glad to have been a part of their lives and to have been bettered by knowing them. We wish them well in their future endeavors and hope to see them from time to time. Dr. Bill Harris Named VP for Research The Department of Chemistry and Biochemistry welcomes new faculty member Dr. William Harris, recently named vice president for research at the University of South Carolina. Dr. Harris is a New York native who earned a Bachelor of Science degree in chemistry from the College of William and Mary in 1966, and a Ph.D. from USC in 1970. He served for almost 10 years as a professor at Furman University and was a Dreyfus Foundation TeacherHarris Scholar, 1975–80. His outstanding career with the National Science Foundation (NSF) included: serving as head of the mathematical and physical sciences; managing a $750 million budget; establishing the Science and Technology Centers Program; developing the complex LIGO, Gemi-Telescope, and Magnet Labs; overseeing the development and funding of 25 interdisciplinary and multiple-institution science and technology centers; initiating the Research Experience for Undergraduates (REU) Program; establishing the Office of Multidisciplinary Activities; and acting as lead support-provider for individual researchers. Dr. Harris also was the president and executive director of Columbia University’s Biosphere 2 Center from 1996–2000. The center, a research and teaching branch of Columbia near Tucson, Arizona, focuses on earth systems science, policy, and management. Dedicated to guiding the University of South Carolina to a more competitive position in terms of peer-recognized academic excellence, Dr. Harris particularly stresses the importance of research development. “Nothing could be more important for the state than to have a nationally prominent research university that is built upon outstanding classroom teaching for our undergraduates and research scholarship that is recognized by scholars from the nation’s leading research institutions.” This new addition to the USC community is sure to be a significant one, and Dr. Harris will undoubtedly accomplish those goals he sets for himself in the Department of Chemistry and Biochemistry, and in the college community as a whole. His optimistic attitude is one we could all take as an example. He says, “We must continuously look toward the future in the pursuit of new knowledge, new ideas, and new discoveries.” Dr. Catherine Murphy Encourages Students to Question Dr. Catherine J. Murphy of the Department of Chemistry and Biochemistry was presented the Michael J. Mungo Teaching Award this June. Each year, five Mungo Awards in the amount of $2,000 each are presented to members of the undergraduate faculty at the University of South Carolina, three going to the College of Science and Mathematics and Murphy the College of Liberal Arts. The awards are presented after careful examination of the candidates’ teaching philosophies and involvement in undergraduate advising, mentoring, and teaching of undergraduate students. After months of consideration, the provost of the University makes the final decision, and honors those professors whose teaching goes above and beyond what is expected. This year, Dr. Catherine J. Murphy received this honor. Dr. Murphy received a Ph.D. in Inorganic Chemistry from the University of WisconsinMadison in 1990, and subsequently accepted a postdoctoral position at the California Institute of Technology, where she remained for three years. In 1993, she began her career in the University’s Department of Chemistry and Biochemistry. Dr. Murphy says, “I am honored to win another teaching award for the chemistry department.” Dr. Murphy’s work with the department has been in the areas of inorganic chemistry, materials science, and physical biochemistry. Her research is in the optical properties of semiconductor clusters, luminescent probes of DNA wrapping and bending, and inorganic coordination compounds for optical sensing. Dr. Murphy is the principal investigator of the National Science Foundation Research Experience for Undergraduates (REU) program in the Department of Chemistry, where she integrates a nanoscience theme, and has had a total of 48 undergraduates and high-school students work in her lab since coming to USC in 1993. Dr. Murphy clearly places importance on her 4 work with undergraduate students, and directs a great deal of energy toward it. She has a clear teaching philosophy that she incorporates into her classes, she says, which has as its focus the “How?” of science. “I try to emphasize in my classes ‘how do we know that?’ and present experiments that demonstrate how we come to know things.” Having this question as the ground of scientific investigation encourages students to delve deeper into the often complex concepts presented in their undergraduate study. What urges a student to learn and to excel is not the sheer memorization of facts and figures, but rather an authentic grasp on the ideas that are the foundation of scientific knowledge, and Dr. Murphy’s philosophy has been facilitating that drive in her students throughout her career in chemistry. Dr. Murphy has had a positive impact on the academic lives of countless undergraduates since 1993, and for this the Department of Chemistry and Biochemistry extends a warm congratulations! Dr. Scott Goode Lends an Ear to Undergraduates The Ada B. Thomas Outstanding Faculty Award is an honor which is given to one faculty member each year who has shown a level of insight and sensitivity to students’ needs to merit recognition. The nominees for the award are elected by undergraduates, who have first-hand experience with the advisors, working closely with them throughout the year. This year, the students have spoken in Goode favor of Dr. Scott Goode, an experienced and dedicated student advisor. Dr. Goode knows all too well the frequent opinion of advising amongst faculty at other schools. “They view it as a chore,” he says. He knows that this attitude can leave students with no one to turn to when they need advice, and perhaps more importantly, no one to nudge them along their chosen path encouragingly. “The trick to advising,” Dr. Goode says, “is not speaking, but listening.” Advisors are not solely authorities who ensure that their students have taken the necessary courses and filled out the proper paperwork, although these technicalities are a part of the position as well. Advisors can often serve as parental figures of a sort; people who care about their students and who are looking out for their best interests. Dr. Goode takes a holistic approach when advising his students, and works to see that, as well as being academically and intellectually secure, students are happy and healthy; indeed, we can only imagine the numbers of students who have gleefully discovered the therapeutic nature of Dr. Goode’s resounding laugh! Because Dr. Goode has spent years listening to his students, he has observed differences in learning styles; certain tendencies students have in their intellectual retention and development. The recognition of these tendencies has helped Dr. Goode to structure the academic careers of his advisees in a manner most beneficial to them. For example, he delineates, “There are some students who are auditory learners—they listen attentively during class, but rarely take notes and don’t spend much time reading the text.” These students, he explains, would do well in those classes with faculty who focus their energies on lectures, but would flounder in classes structured around written information. “There are other students,” he says, “who can’t pay attention during class, but read the text thoroughly, and pass all of the exams.” This observation has given Dr. Goode the ability to match students to the classes best suited to their learning styles, and, in turn, enhance the learning process. “I don’t tell them, ‘take this class, it’s easy.’ I describe to the student how the instructor grades and teaches, and often students decide for themselves.” In addition, Dr. Goode does not forget the lessons he learned during his undergraduate years: “Nothing taught me chemistry like the research I did in school—I always place an emphasis on research as early as possible.” When asked if he dealt with some difficulties in the early years of his advising, Dr. Goode laughs; “Well, my first advisee almost didn’t graduate!” Since that time, Dr. Goode has had a wealth of experience with students, faculty, and the chemistry curriculum that has made him one of the best faculty advisors at USC today. His thoughtful and generous approach to advising has endeared students to him for years, and it has perhaps never been so clear as with the receipt of the Ada B. Thomas award. On behalf of the Department of Chemistry and Biochemistry, congratulations on an award well earned. GSRC continued from page 1 which, according to third-year graduate student Rob Umpleby, “keep people’s spirits up.” The electrical lighting was designed by a lighting engineer. Dr. Goode remarks, “It is not only safer to work in a bright, well-lit lab, but productivity is improved and morale is high.” Dr. Wuthier echoes his sentiment: “Go back to PSC, remember how dingy and dark and dirty everything was there. And the smell; PSC was dank and just smelled old and dirty. How nice it is to be in a clean, bright, new building.” Dr. Thomas Bryson, director of the graduate program, reiterates the excitement of the department: “It’s wonderful to be in a brand-new, very safe research facility.” Following are some interesting facts about the GSRC: •The GSRC is 158,000 square feet. •A lap around the floor is 1/10 of a mile. •The building contains 148 chemical fume hoods. •There are two 200-hp pumps with variable speed drives to supply chilled water up the five air handlers. •The USC energy plant that supplies the GSRC and 1/4 of the campus, only has one 150-hp pump. • GSRC energy utilization is controlled and monitored by Energy Services—they have a remote readout of all our indicators. • The Columbia water pressure is not sufficient to reach the fifth floor, so the pressure is boosted by a pump in the first floor mechanical room—the pressure on the first floor is about 60 psi and it drops 1 psi for every 28 inches of elevation. • There is no hot water tank—the domestic hot water passes through a steam jacket and exits at 120 degrees Fahrenheit. • The ground floor of the GSRC is 299 feet above sea level. • The distance from one floor to the next is 15 feet. • The total cost of construction was $36.6 million and nearly half this cost is in the air handler system and other utilities that run above the ceiling. • The GSRC has class 1,000 and a class 10,000 clean rooms on the second floor. system to control fume hoods. Dr. Catherine Murphy feels that the hoods will increase the quality of work done in the department’s labs. Indeed, Dr. Scott Goode, who has been instrumental in the design and construction of the GSRC, says that one of the most frequent comments he hears from faculty housed in the GSRC is, “The hoods are awesome! For the first time, my students are not working out on an open bench.” This safe, energy-efficient system is impressive—sensors determine whether a researcher is working in a hood, and measure the height to which the hood sash is raised. It also measures pressures in the conditioned air lines and hood exhausts, then adjusts the flow rate to match health and safety standards. None of the air used in the building recirculates. When a researcher prepares to leave the lab, the hood controller senses that lights are out and provides a reminder to lower the sash to save energy. Another benefit that the building offers and which faculty, staff and students emphasize is the lighting. The GSRC has many large windows, 5 Alumni News Michael S. Alexander (BS ’91) is a facility/process engineer for Phillips Petroleum Company in Alaska. William D. Anderson, Jr. (BS ’53) was a biology major at USC who minored in chemistry. He serves as a professor emeritus for the Department of Biology at the College of Charleston. Gary S. Bartley (Ph.D. ’96) is a research scientist at Protein Delivery, Inc. in Research Triangle Park, North Carolina, and is currently developing water-soluble prodrugs of paclitaxel (Taxol) and anti-obesity drug candidates. Dr. Kim W. Baughman (Ph.D. ’83) has been named managing director at Southern Testing and Research Laboratories in Wilson, North Carolina. Jeffrey O. Boles (Ph.D. ’92) has recently been promoted to associate professor at Tennessee Technological University. He is president of the Biochemistry Division of The Southern Association of Agricultural Scientists (SAAS), and associate editor of the SAAS journal Biochemistry and Biotechnology. Bole’s wife Tammy (MS ’92) is the metals specialist at the TTU Center for the Utilization and Management of Water Resources. William H. “Jack” Breazeale, Jr. (Ph.D. ’66) retired from FMU in 1997, and is living in Mt. Pleasant and enjoying coastal South Carolina. He currently teaches part-time at the College of Charleston. He also presents safety workshops for the Laboratory Safety Institute. Dr. Rebecca Bullard-Dillard (Ph.D. ’96) is assistant professor of biology at Claflin College and chair of the Department of Biology. She received the 1998–1999 James Hunter Award for Excellence in Teaching and Education (Claflin College Professor of the Year). She is a board member of the Diversity Advisory Committee at the Medical University of South Carolina, College of Health Professions in Charleston, South Carolina. William J. Egan (Ph.D. ’98) is featured in the June 5 issue of Chemical & Engineering News. The article is about drug discovery and the work he has done with chemometric methods to search databases. He is working at U.S. Pharmacopoeia in Princeton, New Jersey. Curtis N. Gadson (BS ’87) has used his chemistry background in the U.S. Army. He is currently the Installation Chemical Officer for Fort Polk and the Joint Readiness Training Center. Deedra Nunnally (nee Foxworth) (MS, ’96) Jules E. Goldberg, Esq. (MS ’63) has joined the law firm of Reedsmith LLP as a partner in the intellectual property group of the New York office. Sean O’Connor (MS ’78) is the director of Mark Graham (BS ’83) is a graduate of the Medical College of Virginia and currently works as a physician. Judith Iriarte-Gross (Ph.D. ’90) received an early promotion to associate professor in her fourth year at Middle Tennessee State University. She was awarded the MTSU Foundation Outstanding Public Service award in recognition of her work to encourage young women in math and science. Scott A. Jackson (BS ’96) is currently a thirdyear biochemistry graduate student in the lab of Dr. Sarah Woodson at Johns Hopkins University. The focus of his Ph.D. project is RNA-mediated group I intron transposition through reverse splicing. Reka Kovacs (BS ’99) serves as a research assistant at Yale University, in the School of Medicine’s Dermatology Department. David Lynn (BS ’94) received a Ph.D from the California Institute of Technology in June (thesis title: “Water-Soluble Ruthenium Alkylidene Complexes: Synthesis and Application to Olefin Metathesis in Protic Solvents”). He is headed for a post-doctoral position at the Massachusetts Institute of Technology at the end of June1999. and Brian K. Nunnally, Sr., reside in Indianapolis, Indiana. In January 2000, they became the proud parents of a little boy, Brian K. Nunnally, Jr. quality control for CyGene, Inc., in Sunrise, Florida, a company specializing in DNA diagnostics. Blake Otwell (a former postdoctoral fellow in Dr. Bruce Dunlap’s lab in the 1970s) is an assistant professor of chemistry at Jacksonville State University in Jacksonville, Alabama. He received a $60,000 grant from the Alabama Department of Public Health and A.L.E.R.T. for chemical Environmental Monitoring of Terrapin Creek. He and his wife Cynthia adopted a sixmonth old girl named Chanee LeAnne this past spring. Angela McCaskill Roberts (BS ’79) is using her “chemistry” as a home-schooling mom of three boys (ages 7, 9, and 15) and as a minister’s wife in the beautiful mountains northwest of Knoxville, Tennessee. Dr. John W. Schofield (BS ’42) is “doing the best he can.” Donald W. Shenenberger (BS ‘92) received a MD from USC School of Medicine in ’96, and is currently finishing his chief residency year in family practice at the Naval Hospital in Jacksonville. D. Randolph Whitt (BS ’84) is a shareholder in the Columbia law firm of Moses, Koon & Brackett, PC. Dawn McCary (nee Healy) (MS, ’96) works Taffy J. Williams (Ph.D. ’75) has recently for the new J. Org. Chemistry office at the University of Utah, and Jason McCary, who successfully defended his Ph.D. thesis in March and is now in Dale Poulter’s group at the University of Utah, have a son, Jacob, born last December. accepted a position as president and CEO of Photogen, Inc. Photogen is a small biotech company that concentrates on radio- and photo-sensitizers. The focus of the company is diagnosis and treatment of cancer, but the technology may be used to treat other diseases as well. She continues to live in the Philadelphia area. Fred McLean (MS ’85) is a neuroradiologist in a practice in east Tennessee. He likes his job and was recently made a partner in the group. His lives with his wife Laura and their children, Alex (8) and Emily (5), who are a lot of fun and keep them busy. Alexander B. Morgan (Ph.D. ’98) has just started a new job at Dow Chemical Company as a senior research chemist in corporate R&D. 6 Ruilian Wu (Ph.D. ’92) is a senior scientist/synthetic organic chemistry at Admetric Biochem., Inc. Her husband Xiaoming is a senior software engineer at Intel. They and three children (Connie, Kevin and David) have lived in Groveland, Massachusetts, since 1996. Dr. zur Loye Receives Prestigious Professorship zur Loye Dr. Hanno zur Loye was recently awarded the David W. Robinson Palmetto Professorship in recognition of his research accomplishments and his service to the University. “It is a great honor to be awarded such a professorship,” he says. Dr. zur Loye, who was born in Frankfurt, Germany, came to the University of South Carolina as an associate professor from the Massachusetts Institute of Technology in 1996. Having received his training at Brown University, the University of California-Berkeley, and Northwestern University, Dr. zur Loye has enjoyed great success in the laboratory as well as in the classroom. “I very much enjoy teaching. This is the main reason for my being in academia. I teach freshman chemistry in the spring and a graduate course in inorganic materials chemistry as well as University 101 in the fall. This gives me the opportunity to interact with the students.” Aside from teaching courses, he is also responsible for the instruction of his research group, which has 10 members. “I spend a large amount of time teaching my graduate students the ins and outs of research. I talk to them every day to see how they are doing and how their research is going. This can take minutes to hours, depending on circumstances. It’s fun to be in the lab, if only to talk to my students,” he says. Dr. zur Loye took to chemistry at an early age. He cites his high school chemistry teacher, Mr. Kietrys of Mendham High School in New Jersey, as one of his strongest influences. Though Dr. zur Loye gravitated initially towards natural products synthetic chemistry as an undergraduate at Brown, a course in inorganic chemistry with Professor Aaron Wold proved pivotal. “It was an exciting class and convinced me that I wanted to change directions. I took two more inorganic classes with him and worked in his laboratory for one-and-ahalf years. Working in his lab got me interested in solid state materials chemistry.” This interest in solid-state chemistry led him to study at UC-Berkeley with Professor Angy Stacy. Though Dr. zur Loye sometimes misses the weather at Berkeley, his feelings toward the Department of Chemistry and Biochemistry at USC are resoundingly warm. “The department is one of the most collegial that one can imagine. There are lots of collaborations that arise naturally because everybody is interested in working together. This sets us apart from most other places,” he says. A good situation got even better once the department moved into the Graduate Science Research Center (GSRC). “I am extremely happy that we finally moved. Now we have a state-of-the-art facility, customdesigned to some extent, which enables us to carry out our research. The GSRC is a great building.” Dr. zur Loye’s research group is currently engaged in three separate projects. The first is in collaboration with a research group in France headed by Jacques Darriet. The project concerns the growth of oxide single crystals and the determination of their structures and the measurement of their physical properties. These oxides often crystallize in structures that are modulated and must be solved in four-dimensional space, as they are aperiodic in three dimensions. The NSF supports this program, and, starting next summer, together with ShiouJhy Hwu at Clemson University and Angus Wilkinson at the Georgia Institute of Technology, Dr. zur Loye will be running the NSF Undergraduate Summer Research Program in Solid State Chemistry for the next four years. 7 His group is also investigating new catalysts for the production of hydrogen gas from natural gas. They work with Professor Michael Amiridis in chemical engineering at USC on the production of CO and CO2-free hydrogen that can be used in fuel cells without the need for further purification. Lastly, he is working on organic/inorganic hybrid structures. This work is done in collaboration with Professor Uwe Bunz and his research group here in the chemistry department. They are working on the synthesis of new organic/inorganic framework materials that have applications in air separation and selective absorption and in catalysis. “We’ve synthesized over 100 new materials with new structures in the last two years, and we are picking up the pace. This is one of the most fun areas of chemistry that I have ever worked in. It’s fastpaced, exciting, and full of the unexpected.” Dr. zur Loye keeps quite busy and has additional responsibilities as the director of graduate admissions for the Department of Chemistry and Biochemistry, as well as being an associate editor for the Journal of Solid State Chemistry, section editor for Chemtracts: Inorganic Chemistry, and a member of the editorial board for the Journal of Alloys and Compounds, and Solid State Ionics. In his offtime he spends time with his family, plays golf when he can, and is hard at work teaching his five-year-old son, Karl, to speak German. Looking for up-to-date alumni news? Interested in faculty research? Want to attend a seminar? Visit our Website! http://www.chem.sc.edu Dr. James Sodetz Esteemed in Field of Research Each year USC recognizes several faculty members for outstanding scholarship. The Russell Research Award was established in 1957 and is the University’s most prestigious annual prize for research. The award is given for innovative research or creative achievement on a significant subject; this is defined as the collection and organization of data with new insights into and understandings of a defined problem, subject, or theme. This year Dr. James M. Sodetz of the Department of Chemistry and Biochemsitry is the recipient of the Russell Research Award in Science, Mathematics, and Engineering for his research on the human “complement” system. Dr. Sodetz received a Ph.D. in Biochemistry in 1975 from the University of Notre Dame and was an NIH Postdoctoral Fellow at Duke University Medical School from 1975–77. He joined the USC faculty as an assistant professor in 1978, and is currently a Carolina Distinguished Professor of Biochemistry in our department and the director of Medical Biochemistry for the USC School of Medicine. His major research interest is in the structure, function, and molecular genetics of a group of human blood proteins that work together with the immune system to destroy bacterial cells and other pathogens. The research uses cloning and recombinant DNA technology to produce altered forms of these proteins that can be used in studies of how they disrupt the integrity of cell membranes and thereby kill a cell. The NIH has supported Dr. Sodetz’s research at USC for 20 consecutive years, with additional support being provided by the NSF, the American Heart Association, and the American Cancer Society. That NIH has funded his project for so long is a remarkable achievement; it is very difficult to obtain and especially to sustain NIH funding. In 1982 he received the prestigious five-year Established Investigator Research Award from the American Heart Association. He has been principal investigator on 4.5 million dollars in external grants while at USC, and has published over 50 full papers in peer-reviewed journals and has authored several book chapters and review articles. He has served as an associate editor of the Journal of Immunology, the most prestigious journal in the area of immunology, as well as serving on numerous grant review panels at the local, national, and international level, including those for the American Heart Association, NSF, and NIH. Dr. Sodetz’s research is specifically concerned with how five protein components of the complement system (designated C5b, C6, C7, C8, C9) interact and assemble to form a macromolecular complex on target cell membranes. This “membrane attack complex” (or MAC) disrupts the membrane structure of a target cell, which leads to cell killing in the case of bacteria or the triggering of inflammatory responses in the case of mammalian cells. For nearly 20 years he has been studying the mechanism by which this occurs, and has approached this through detailed structure-function studies of one of the components, i.e. human C8. This protein is unusual in that it is composed of three different polypetide chains (subunits) each of which is encoded by a different gene. Dr. Sodetz’s research began with the development of purification procedures to obtain high yields of C8 from human blood. This was followed by basic studies of the physical and chemical properties of C8. Subsequently he moved into the area of C8 molecular biology and genetics. His lab isolated and utilized human DNA clones to determine the complete amino acid sequence of C8 and its constituent genes. This information was crucial in that it revealed that C8 was derived from the same ancestral gene as C6, C7, and C9, and that together these proteins comprise what is now referred to as the “MAC protein family.” It also facilitated development of rapid PCR-based screening methods to detect point mutations in the gene. Dr. Sodetz’s lab determined through analysis of yeast artificial chromosomes (YACs) that two of the C8 subunits are closely linked on human chromosome 1. Dr. Sodetz’s most recent efforts have taken advantage of the many reagents and tools developed in his lab. He is now using recombinant DNA approaches to study C8 structure and function. He successfully developed methods to produce all three human C8 subunits in cultured insect cells and monkey kidney cells and is using this system to map the location of important binding sites in C8. At the present time, his lab is using the elegant approach of designing chimeric recombinant C8 proteins in which specific segments of the human C8 subunits are exchanged. These are cutting-edge experiments that are technically very difficult because of the 8 multi-subunit nature of C8. One of their longterm goals is to identify functionally important segments of C8 and develop recombinant analogues (fusion proteins, chimeras, etc.) that can be targeted to attack undesirable human cells, e.g. tumor cells. Dr. Sodetz’s important research has prompted several invited articles in the past few years, and he recently wrote a book chapter on the MAC family of proteins, the first such comprehensive review of these proteins and their genes. He’s also been asked to write a chapter for a new series entitled The Encyclopedia of Life Sciences to be produced by the publishers of Nature and Scientific American. He has a chapter on C8 in press in the Academic Press’s FactsBook series and he was recently invited to contribute a review article on C8 for a special ‘Lipocalins’ issue of BBA-Protein Structure and Molecular Enzymology to be published in Biochimica et Biophysica Acta. Dr. Sodetz’s research accomplishments are important to understanding protein structurefunction in general and the MAC proteins in particular. His research achievement ranges from the most basic protein chemistry and molecular biology to the gene and the most sophisticated level of study: producing recombinant human proteins. Throughout the gamut of his experience, Dr. Sodetz has demonstrated innovation and creativity by applying inventive methodologies and technologies to the study of this complex system. USC Chemist is written and edited by Psyche Ready, with help on this issue from Shawn Miller and Guy Lipscomb. To contribute alumni news or feedback: Web: www.chem.sc.edu/news/alumni/alumniinfo or follow the links from the department’s homepage, www.chem.sc.edu Or write: USC Chemist, Department of Chemistry and Biochemistry, University of South Carolina, SC 29208. E-mail: chemweb@mail.chem.sc.edu Student Awards The department is proud to be the home of a number of talented students who have been recognized at the departmental, University, and state levels. Following are some recent honorees. Life Scholars Brandi Nichole Andrews Joshua B. Aronson Patrick Atkinson Jonathan D. Black Nefertiti A. Brown Eric E. Childers Brandi L. Clelland Maribeth C. Coleman Gregory B. Collins George A. Cooper Emily S. Cox Mary E. Dalton John N. Dantzler Nathaniel T. Green Mark M. Hartney Stephanie E. Hooper Thua Huynh Brent A. Keener Courtney T. King William Klauber Jacob Lasovage Dennis B. Martin Kristen A. Matthews Randolph B. Meekins Megan J. Nikolai Shital J. Patel Angela C. Powell Kyle D. Proffitt Lan T. Quan Carrie A. Sanders Matthew J. Shmanske Sandra Leigh Shotwell Marisha L. Swinger Pamela L. Tisdale James N. Wilson Bouknight Teaching Award Winners The following graduate students were honored for outstanding teaching: Fall 1999 John Berch Christopher Dyke Brian Long Kimberlyn Caswell Andrea Jurgens Christopher Mubarak Spring 2000 Steven Dubose Matthew Davis Vanessa Kinton Thomas Metz Della Smith Chris Mubarak Fall 2000 Brittnaie Bell Paula Colavita Vanessa Kinton Chris Mubarak Sherine O’Bare Ruya Ozer Shane Ricker Spring 2001 Brittnaie Bell Paula Colavita Vanessa Kinton Chris Mubarak Sherine O’Bare Ruya Ozer Shane Ricker These students were awarded travel funds to present research at national and international conferences: June 2000 Rosemarie Chinni Yong Chong Charles Degenhardt III Li Kong Narendra Meruva Marjorie Nicholson Dimitra Stratis Robert Umpleby II Yunhan Zhang October 2000 Kristine Eland Lori Grabill Richard Hoskins Christine Little Friday, October 19, 2001 1:30 p.m. You are invited to attend! Durig Travel Award Winners February 2000 Steven Dubose Kristine Eland Quincy Ford Susan Glenn Vanessa Kinton Narendra Meruva Primrose Musingarimi Sherine O’Bare Allison Oxsher Ruya Ozer Neil Pschirer Kristen Sellers Winfried Steffen Shane Waybright Jessi Wildeson Graduate Science Research Center Building Dedication Narendra Meruva Chris Mubarak Michael Nivens Allison Oxsher Terri Wright February 2001 Rosemarie Chinni Shalawn Jackson Sherine O’Bare Katharine Stitzer Robert Umpleby II Featuring: - Tours of the GSRC and labs - Meet with faculty and students Speakers: Dr. Harry Gray, Arnold O. Beckman Professor of Chemistry, director of the Beckman Institute at the California Institute of Technology Rear Admiral Jay Cohen, Office of Naval Research Please call Ann Cameron at 803-777-9201 for details. 9 Faculty and Staff News Dr. Richard D. Adams has been placed in an inaugural position as the director of the new Nanoscience Research Center at USC. He also received the American Institute of Chemists Chemical Pioneer Award and was a fellow of the American Institute of Chemists. Additionally, he was awarded the Outstanding South Carolina Chemist of 2000 Award by the South Carolina section of the American Chemical Society, and was re-appointed as the Arthur Sease Williams Professor of Chemistry. He spent the spring 2000 semester in Germany at the Technical University of Munich, the University of Karsruhe, and the University of Erlangen-Nurnberg as the first Senior Humbolt awardee from the USC chemistry department. During this time, he gave lectures at 17 major universities in Europe. Dr. John W. Baynes was appointed to the editorial board of BioGerontology, Kluwer Academic Publishers, The Netherlands, and, in addition, was re-appointed as a Carolina Distinguished Professor. Dr. Mark A. Berg was one of 10 scientists elected by the Division of Chemical Physics to fellowship in the American Physical Society. Dr. Uwe Bunz received the Camille Dreyfus Teacher-Scholar Award. Dr. R. Bruce Dunlap was re-appointed as the Fred M. Weissman Palmetto Professor of Chemical Ecology, and he and his former postdoctoral fellow, John G. Moore, were awarded the South Carolina Alliance for Minority Participation Outstanding Research Mentor Award. Dr. Michael L. Myrick was awarded the 1999 Imaging Solution of the Year Award, Advanced Imaging Magazine. Dr. Daniel L. Reger was awarded the Carolina Trustee Professorship, awarded yearly to the University’s best professor demonstrating excellence in a combination of research, teaching, and service. Dr. Reger was also re-appointed as a Carolina Distinguished Professor. Dr. Jorge M. Seminario published Advances in Quantum Chemistry: Density Functional Theory, Academic Press, New York, NY, 1999, and, with Dr. P. B. Balbuena, Molecular Dynamics: From Classical to Quantum Methods, Elsevier, 1999. Dr. Timothy Shaw spent a year in Germany as a recipient of a prestigious nine-month fellowship from the Hanse Institute for Advanced Study to conduct research at the Universities of Bremen and Oldenburg and to give a series of lectures. Dr. Roy E. Wuthier received a patent, “Angiogenesis Inhibitor for the Treatment of Cancer.” Dr. Elizabeth H. Griffith and Dr. Licia Wu received 20-year state service awards for 2000, and Ms. Sherri Howell-Redmond, Dr. Masonori Sono, and Ms. Helga J. Cohen received the award for 2001. Dr. Brian R. Genge and Sherry L. Morrison received 10-year state service awards for 2000, and Dr. Bill Cotham received the award for 2001. Lipscomb continued from page 1 average on the quizzes. I well remember having a 94 average. I had to take the exam and was disappointed with a B! My courses were aimed at a premedical degree and I prevailed but never applied to medical school. I was an ordinary student who had to work hard to get reasonable grades. Dad knew what was needed—he told me that if I didn’t have a B average every semester, I would have to drop out of all extra activities—no more basketball, no more tennis, no more track, no more fraternity, no more girls! Well—you know who made a B average! I loved competing on the USC teams and all the rest, so I burned the midnight oil. I had a couple of Cs so I took two courses that I was sure I could make an A in and pull up the Cs. One was a New Testament course and the other was sex hygiene, and, to my great disappointment, I got a B in both. Everybody in the hygiene class read the book in the first two weeks and then proceeded to forget what we learned. Woe to me! I learned chemistry from Dr. Whitsell, Dr. Copenhaver, Professor Lincoln Moore and my father, but I did not have a driving desire to go to medical school. Dad and Dr. Penny along with a student, Fred Killingsworth, started a little enterprise in a vacant room under the steps at the old LeConte College building. No windows, no ventilation, one door! This was the beginning of a manufacturing effort, which attracted me upon graduation. After additional graduate work and stints with DuPont and Goodyear, I returned to Columbia and worked with my father in the fledgling manufacturing business that grew over the years to become Anchor Continental, an elastimer and tape manufacturing company located in Columbia. I worked closely for eight years with my father after his retirement from USC in 1949 and was responsible for the company from 1958 to 1979 when an English firm purchased it. At the time of the sale there were more than 600 employees. My brother-in-law, Mr. George Fant, became president in 1975 and ran the firm for the English company until his retirement. My life-long interest in art had continued to grow and I began to be a very serious student of painting. This passion has continued as I have studied with many professionals, taught workshops across the country and Canada, written a book on painting in watercolor, and shown my work in over 100 national open juried shows through the years, receiving a number of awards. Painting is still my major activity as I enter my 84th year, along with (fol10 lowing in order of interest) gardening, reading, and golf. Upon the sale of Anchor Continental, I was able to form a family foundation involving my four daughters, my brother-in-law, and my wife. Its mission has been aimed at the problems of youth and family along with other established institutions affecting the quality of our growing population of young people in the South. It has been a difficult but rewarding effort for all of us. I continue to be very thankful for what the University of South Carolina has meant to my family and myself, and I encourage all graduates to repay their debt to this great school. We would like to invite other friends and alumni to submit any photos or stories to the USC Chemist that might provide a glimpse into the history and intellectual life of the University of South Carolina. You may contact us at: USC Chemist Department of Chemistry and Biochemistry University of South Carolina Columbia, SC 29208 E-mail: chemweb@mail.chem.sc.edu Phone: 800.868.7588 Letter From the Chair with the acquisition of a new class of X-ray diffractometer and an outstanding lab director, Dr. Mark Smith. For those of you familiar with this technique, we can now do structures of several compounds per day and can solve structures of very large molecules even if only small crystals are available. We are very excited about the Graduate Science Research Center Dedication, which will be held at 1:30 p.m., Friday, October 19. Dr. Harry Gray, the Arnold O. Beckman Professor of Chemistry and director of the Beckman Institute at the California Institute of Technology, will offer the keynote address. He is a member of the National Academy of Sciences and the American Academy of Arts and Sciences. Other dignitaries, including Rear Admiral Jay Cohen from the Office of Naval Research will also offer remarks. Guests at the ceremony will have an opportunity to tour many of our labs, and visit with faculty and students. After the ceremony, Dr. Harry Gray will offer a public lecture that will begin at 3:15 p.m. in Bouknight Auditorium. The dedication will be the kickoff for many exciting Homecoming activities that weekend. We hope that all graduates and friends of the Department of Chemistry and Biochemistry will attend. If you have any questions about the dedication or other Homecoming activities, please call Ann Cameron at 803-777-9201. In conjunction with the dedication of the Graduate Science Research Center, the Department of Chemistry and Biochemistry has announced a $10,000,000 Cornerstone for Discovery Capital Campaign. To attract and retain the best students, faculty, and professional staff, we seek endowment funds to meet three crucial objectives: 1. to offer competitive graduate student fellowships 2. to enhance undergraduate research opportunities and initiate a senior-level capstone course providing real-world experiences for chemistry majors 3. to create a research and development fund whose proceeds would provide matching funds for research proposals, seed money for exploratory research, incentive funds to promote research collaboration, and support funds to assist faculty in moving in new research directions. Naming opportunities exist, ranging from $25,000 for a faculty office to $10,000,000 for the Graduate Science Research Center. To learn more about how you can arrange a naming opportunity, please contact 803-777-0455. As the new chair of the Department of Chemistry and Biochemistry I want to use this opportunity to introduce myself and outline some of the exciting happenings in our department. First, I wish to express the feelings of the entire department in thanking Bruce Dunlap for an outstanding job as chair for the past six years. He has worked tirelessly for the department, pushing us Reger ahead in many ways, most importantly in the hiring of outstanding faculty and staff and in the area of development. Still active, he continues his outstanding service to the department and to the University. If you are wondering who the new kid on the block is, let me introduce myself. I have been a member of the Department of Chemistry and Biochemistry since 1972. I have run an active research group, with funding from the NSF, NIH, PRF, and DOE. I have had 24 students receive the Ph.D. degree working in my labs and have published 130 research papers. I teach introductory chemistry as well as senior- and graduate-level courses, and am very proud to be the fifth member of the department over the years to be awarded the University’s top award, the Amoco Undergraduate Teaching Award (Drs. Bouknight, Teague, Odom, and Goode are past winners). I have written a text for introductory chemistry, with Drs. Goode and Mercer of this department, that is used here and elsewhere across the country. I also served a two-year term as associate dean of research and finance in the College of Science and Mathematics. I take over the reins of an outstanding department and only hope I can do as good a job leading it as that done by my predecessors. We have been in our new building now for one year and it is clear that the dramatically improved conditions for our researchers are having a major impact on the quality of research being carried out in the department. As a synthetic chemist, I am particularly pleased with the quality and number of fume hoods on our synthetic floors. The number of hoods in my laboratory has increased from three to eight. My students do 100 percent of their chemistry inside the hoods. Frankly, I do not see how my group survived (I am sure my past group members agree) the last 10 years in the old building. In conjunction with the move, we improved the quality of our instrumentation, especially in our outstanding NMR and Mass Spectral Centers. We also established a new center in X-ray crystallography 11 Department Welcomes Organic Chemist In 1989 Dr. Wally Scrivens was an undergraduate in the Honors College at USC. Today he is an assistant professor of organic chemistry in the Department of Chemistry and Biochemistry. During his time as an undergraduate, Dr. Scrivens did research in synthetic chemistry in the labs of Drs. Bob and Ruta Bly and computational work with Dr. Jim Marshall. “I’ve always wanted to be a scientist, but it was only late in my college career that I seriously considered science as a career option. I guess I figured you couldn’t make a living doing science.” He tried his hand at medical school at USC, though the experience wasn’t much to his liking. He found himself logging in excess of 100 hours a week studying, and he “still wasn’t studying enough,” he says. The real trouble with medical school was that it failed to captivate his imagination in the way his undergraduate research experiences in chemistry had. So, Dr. Scrivens returned to USC and earned a second BS degree, this time in chemistry. In 1994, he earned a Ph.D. from USC under the tutelage of Dr. Jim Tour. He then went to work for Milliken Chemical in Spartanburg, South Carolina as a research chemist in patent defense cases and scalingup reactions at the Milliken plant. Though the work was enjoyable, Dr. Scrivens lamented the lack of intellectual freedom. “It got to the point where I was building a laboratory in my back yard so that I could do the fun and interesting science that I couldn’t do at work.” Now that Dr. Scrivens has traded his backyard labs for those of the Graduate Science Research Center (GSRC), he is pursuing his research in polymer and materials science. “Some of my current work is fairly applied and borders on chemical engineering, although I am University of South Carolina Department of Chemistry and Biochemistry Columbia, SC 29208 doing a lot of traditional synthetic organic chemistry as well. My pet project right now is making purely polymeric telescope mirrors for space applications,” said Dr. Scrivens. Ever inventive and resourceful, he uses an old turntable to produce these mirrors. Though he has taken a circuitous route from and back to the department, Dr. Scrivens is quite happy to be a faculty member at USC. “I still feel a little awkward calling some of my former professors by their first names, but I think that will eventually pass.” The robust air-conditioning in the GSRC, however, does sometimes throw him for a loop— he’s used to his lab goggles fogging up during the summer as a graduate student working in the muggy Jones Physical Sciences Center. Dr. Scrivens has been associated with the University for some time now—his wife, Connie, is the assistant director for undergraduate admissions—and it’s fair to assume that he’ll be a part of the Carolina community for some time to come. NON PROFIT ORGANIZATION U.S. POSTAGE PAID PERMIT #766 COLUMBIA, SC 12