New York, NY PROGRAM Founding Members Jeremy Mao, Columbia University Nadya Lumelsky, National Institutes of Health Darwin Prockop, Texas A&M University Pamela Robey, National Institutes of Health Conference Chairs Jeremy Mao, DDS, PhD, Professor, Columbia University Michel Goldberg, DDS, PhD, Professor Emeritus, University of Paris V ========================================================== May 10, 2016 (Tuesday) 12:00 pm -5:00 pm Check-in and registration 1 | P a g e Day 1 May 11, 2016 Wednesday 7:00 –9:00 am Check-in and registration; Breakfast provided 9:00 am Opening Ceremony 9:00 am Welcome speech: Dr. Jeremy Mao, Columbia University and Dr. Michel Goldberg, University of Paris V 9:15 am Welcome speech: Dr. Christopher Fox, Executive Director, International Association for Dental Research (IADR) 9:20 am Welcome speech: Dr. Christian Stohler, Dean, Columbia University College of Dental Medicine (Host of 1st ICDCSC) 9:25 am Welcome speech: Dr. Xuedong Zhou, Dean, West China School of Stomatology, Sichuan University (Host of 2nd ICDCSC) 9:30 am Welcome speech and Official Opening of the Conference: President, University of Paris V 9:35 am Dr. Jeremy Mao - Introduction of Dr. Hans Clevers (Confirmed) 9:40-10:15 am Dr. Hans Clevers – Plenary address: Lgr5 stem cells 10:15-10:25 am Q&A 10:25 – 11:05 am Coffee/tea break Session 1: Genetics and epigenetics of stem cells Moderator/Discussion Leaders: Dr. Nadya Lumelsky and Dr. Kerstin Galler 11:05 am Dr. Paolo Bianco, Sapienza University of Rome (Confirmed) Skeletal stem cells 11:30 am Dr. Darwin Prockop, Texas A&M University (Confirmed) Systemic effects of stem cells 11:55 am Dr. Cun-yu Wang, University of California Los Angeles (Confirmed) Epigenetics of stem cells 12:20-12:30 pm Panel and Audience Discussion 2 | P a g e 12:30 pm–2:00 pm Poster Viewing and Lunch (box lunch provided) Session 2: Stem Cells and Craniofacial Development Moderator/Discussion Leaders: Dr. Paul Cooper and Dr. Ove Peters 2:00 pm Dr. Irma Thesleff, University of Helsinki (Confirmed) Regulation of epithelial stem cells in mouse incisors 2:25 pm Dr. Ophir Klein, University of California San Francisco (Confirmed) Long in the tooth: insights into dental stem cells from developmental genetic studies 2:50 pm Dr. Paul Sharpe, King’s College London (Confirmed) The rodent incisor mesenchymal stem cell niche 3:15 pm Panel and Audience Discussion 3:25 – 3:55 pm Coffee/tea break Session 3: Lineage derivatives and functional models Moderator/Discussion Leaders: Dr. Will Giannobile and Dr. Anibal Diogenes 3:55 pm Dr. Jill Helms, Stanford University (Confirmed) Wnt and other developmental signals 4:20 pm Dr. Paul Cooper, University of Birmingham (Confirmed) Dental mesenchyme stem cells and dentin 4:45 pm Dr. Bing Hu, Plymouth University (Confirmed) Dental stem cells and tooth regeneration 5:10 pm Panel and Audience Discussion 5:20 pm End of Day 1 3 | P a g e Day 2 May 12, 2016 Thursday 7:30 – 9:00 am Check-in and registration; Breakfast provided 9:00 am CRISP/Cas9 Workshop - Edward J. Perello, Desktop Genetics 9:05 – 9:40 am 9:40 – 9:50 am Q&A 9:50 – 10:20 am Coffee/tea break Session 4: From development to tissue regeneration models Moderator/Discussion Leaders: Dr. Anthony Smith and Dr. Ove Peters 10:20 am Dr. Jeremy Mao, Columbia University (Confirmed) Regeneration by stem cell homing: craniofacial vs. non-craniofacial systems 10:45 am Dr. Alastair Sloan, Cardiff University (Confirmed) Pulp and dentin regeneration models 11:10 am Dr. Jacques Nor, University of Michigan (Confirmed) Endothelial progenitor cells and pulp regeneration 11:10-11:20 am Panel and Audience Discussion 11:20 – 1:30 pm Poster Viewing and Lunch (box lunch provided) Session 5: Tooth regeneration: genetics and cell sources Moderator/Discussion Leaders: Dr. Paul Krebsbach and Dr. Stéphane Simon 1:30 pm Dr. Donald E. Ingber, Harvard University (Confirmed) Mechanical compaction of cells in tooth regeneration 1:55 pm Dr. Richard Maas, Harvard University (Confirmed) Stem cells and tooth development in genetic models 2:20 pm Dr. Tahashi Tsuji, Tokyo University of Science (Confirmed) Tooth regeneration and parallel models 4 | P a g e 2:20-2:30 pm Panel and Audience Discussion 2:30 – 3:00 pm Coffee/tea break Session 6: Beyond replacement cells: stem cell interactions with immune systems and inflammation Moderator/Discussion Leaders: Dr. Kaj Fried and Dr. George Huang 3:00 pm Dr. Sandu Pitaru, Tel Aviv University (Confirmed) Oral mucosa stem cells 3:25 pm Dr. Rulang Jiang, University of Cincinnati (Confirmed) Dental stem cells and tooth development models 3:50 pm Dr. Anh Le, University of Pennsylvania (Confirmed) Stem cells and immune regulation 4:15-4:25 pm Panel and Audience Discussion 4:25 pm End of Day 2 5 | P a g e Day 3 May 13, 2016 Friday 7:30 - 9:00 am Check-in and registration, Breakfast provided 9:00 am Dr. Pamela Robey - Introduction of Dr. Fiona Watt (Confirmed) 9:05 – 9:40 am Dr. Fiona Watt – Plenary address (Confirmed) Epithelium and hair follicle stem cells 9:45-9:50 am Q&A 9:50 – 10:20 am Coffee break Session 7: Stem cells and niche Moderator/Discussion Leaders: Dr. Rena D’Souza and Dr. Martin Kim 10:20 am Kaj Fried, Karolinska Institutet (Confirmed) Neural origin of dental stem cells 10:45 am Dr. Jake Chen, Tufts University (Confirmed) Modified induced pluripotent stem cells (iPSCs) enhance wound healing of critical-size calvarial bone defects in a mouse model 11:10 am Dr. Yang Chai, University of Southern California (Confirmed) Gli1+ dental stem/progenitor cells 11:10-11:20 am Panel and Audience Discussion 11:20 – 1:30 pm Poster Viewing and Lunch (box lunch provided) Session 8: Dental and craniofacial regeneration Moderator/Discussion Leaders: Dr. William Giannobile and Dr. Ole Jensen 1:30 pm Dr. Michel Goldberg, University of Paris V (Confirmed) Dentin and odontoblast biology and development 1:55 pm Dr. Ling Ye, Sichuan University (Confirmed) Wnt regulation of odontogenesis 2:20 pm Dr. Thomas Diekwisch, Baylor College of Dentistry (Confirmed) Cell-cell interaction networks in engineered stem cell niches 6 | P a g e 2:20-2:30 pm Panel and Audience Discussion 2:30 – 3:00 pm Coffee/tea break Session 9: From Tissue Regeneration Back to Stem Cell Biology: Moving Forward Moderator/Discussion Leaders: Dr. Songlin Wang and Dr. Greg Chotkowski 3:00 pm Dr. Pamela Robey, NIH/NIDCR (Confirmed) Cell processing, GMP facilities and translational use 3:25 pm Dr. Matthew Hoffman, NIH/NIDCR (Confirmed) Epithelium stem cells and salivary gland 3:50 pm Dr. Paul Krebsbach, University of Michigan (Confirmed) Molecular signaling of pluripotent stem cells 4:15-4:25 pm Panel and Audience Discussion 4:25 pm New Investigator Awards presentation Dr. Yoshimitsu Abiko, President, IADR Dr. Christopher Fox, Executive Director, IADR Dr. Paul Krebsbach, President, American Association for Dental Research Dr. Philip Stashenko, DMD, PhD, President, Forsyth Institute Dr. Christian Stohler, Dean, Columbia University College of Dental Medicine Dr. Xuedong Zhou, Dean, West China School of Stomatology Dr. Jeremy Mao Dr. Michel Goldberg Closing remarks 5:00 p.m. Conference concludes 7 | P a g e