EDUCATOR IMPLEMENTATION GUIDE Pharmacology Made Easy® 2.0 Pharmacology Made Easy® 2.0 Educator Implementation Guide © 2012 Assessment Technologies Institute®, LLC Pharmacology Made Easy® 2.0 Table of Contents Description................................................................................................... 1 Features....................................................................................................... 1 Benefits........................................................................................................ 3 Recommended Use...................................................................................... 4 Implementation Strategies.......................................................................... 4 Examples of Student Learning Activities..................................................... 6 Recommended Time Spent......................................................................... 6 Product Support........................................................................................... 6 Technical Requirements .............................................................................. 7 Pharmacology Made Easy 2.0 Module Outline........................................... 8 Pharmacology Made Easy 2.0 Content Outline.......................................... 9 References................................................................................................. 20 © 2012 Assessment Technologies Institute®, LLC III Pharmacology Made Easy® 2.0 Description Pharmacology Made Easy® 2.0 is an audiovisual, interactive, media-rich, online tutorial designed to help students learn about pharmacology and drugs given in practice. The tutorial contains 12 modules with about 200 prototype drugs addressed. Each module focuses on drugs that relate to a body system and contains detailed drug information related to the drugs’ use in the management of alterations in health. Features ●● ●● NEW: Introduction to Pharmacology module Each module begins with a brief review of the anatomy and physiology of the body system of focus. ◯◯ ●● Drugs are presented by category for easier learning. ◯◯ ●● Each category focuses on a prototype drug. Dynamic presentation of media-rich pharmacology content ◯◯ ◯◯ ◯◯ ●● Rich media and animations are included to enhance learning. Navigation is easy to use. Extensive use of images and illustrations help explain and illustrate concepts. Narration teaches proper pronunciation of the names of drugs. Drug information tables address: ◯◯ Therapeutic effects ◯◯ Side and adverse effects ◯◯ Interventions ◯◯ Administration ◯◯ Patient instructions ◯◯ Contraindications ◯◯ Precautions ◯◯ Food and drug interactions © 2012 Assessment Technologies Institute®, LLC 1 Pharmacology Made Easy® 2.0 ●● Drug information tables are printable. (Look under the Resources icon in the modules.) ●● Drug-related safety alerts ●● Drug therapy across the lifespan ●● Guidelines for patient education ●● ●● ●● ●● Videos that simulate providers interacting with patients focus on the clinical application of drug information. 10-item drills at the conclusion of each module reinforce content and enhance learning. Flag for Review feature on module tests allows student to skip a question and go back to it later with no penalty. 25-item NCLEX-style tests provided at the end of each module assesses knowledge acquisition. ◯◯ ●● ●● Rationales provided for both correct and incorrect answer choices. Individual and group reports can be generated. ◯◯ Tests – Time spent and percent correct ◯◯ Modules – Time spent and dates accessed The Critical Thinking Guide is a quick reference tool that is available within every module. (Look for the Critical Thinking Guide icon.) It presents the essential elements of the ATI Helix of Success. It reviews: ◯◯ Knowledge and clinical judgment ◯◯ Priority setting frameworks ◯◯ Critically reading test items © 2012 Assessment Technologies Institute®, LLC 2 Pharmacology Made Easy® 2.0 Benefits ●● Promotes student success in nursing education (traditional, online) ◯◯ ◯◯ Introduces drug categories and drugs, as well as reviews related disease processes Teaches all students to: ■■ Monitor for the expected therapeutic effects of drugs. ■■ Understand the pharmacologic action of drugs. ■■ Anticipate common side and adverse effects of drugs. ■■ ■■ ■■ ■■ ◯◯ ◯◯ ◯◯ ●● Provide needed patient education regarding prescribed drugs. Avoid giving drugs to patients who could be harmed by their use. Recognize potential interactions that can cause adverse and even life-threatening effects. Provides a quick review of drugs for students outside of their pharmacology course Drug tables provide a quick reference tool for the prototype drugs. Drug tables can be used to prepare for drug administration during clinical. Promotes student success on the NCLEX ◯◯ ●● Apply drug knowledge and use proper technique during drug administration. Provides an excellent review of the most common categories of drugs and their prototype Promotes success in nursing practice ◯◯ Provides an excellent resource for practicing nurses and students in graduate nurse programs © 2012 Assessment Technologies Institute®, LLC 3 Pharmacology Made Easy® 2.0 ●● Supports faculty instructional strategies ◯◯ ◯◯ ◯◯ ◯◯ Easy-to-understand and attention-catching format with audiovisual and interactive media Provides initial learning, in-time learning, and content review Can be used for independent study or as an adjunct to a traditional or online pharmacology course Selected modules or categories of drugs can be assigned as an adjunct to lecture in any course. Recommended Use ●● Lecture aid ●● Classroom discussion ●● Independent study ●● Preparation for faculty-prepared pharmacology exam ●● Preparation for standardized pharmacology exam ●● Preparation for clinical practice ●● Clinical post-conference ●● Remediation activity ●● Preparation for NCLEX and other certification exams ●● Preparation for initial position post-graduation Implementation Strategies ●● ●● ●● Review Introduction to Pharmacology module at the beginning of a pharmacology course. Use other modules during pharmacology course to support didactic content. Assign students modules/drug categories to review prior to pharmacology class. © 2012 Assessment Technologies Institute®, LLC 4 Pharmacology Made Easy® 2.0 ●● ●● ●● ●● ●● ●● ●● Provide students with a clinical scenario, and have them identify potential drugs for the client and related information. Develop a quiz-style game using categories of drugs, and have groups of students compete against each other. Develop a “What’s My Drug” game by giving a student a drug’s name or drug table and having other students ask “Yes” or “No” questions in an attempt to guess the name of the drug. Cut out the boxes of selected drug tables, and have a group of students attempt to reassemble them. Role play the emergency care provided to a patient who is in anaphylactic shock. Have small groups of students plot a graph of the onset, peak, and duration times of various types of insulin. Using the Internet, have students make a list of foods and drugs to be avoided by patients on MAO inhibitors. ●● Discuss provided safety alerts with students during in-class discussions. ●● Assign students drugs for which to identify additional safety alerts. ●● ●● ●● ●● Have students role play patient teaching about assigned drugs with each other in class. Review the drills located at the end of each module as a formative evaluation of student knowledge. Foster rich in-class discussion by viewing video case studies in class with students. Require completion of modules as a content review prior to in‑class examinations. ●● Assign module tests as practice or graded exams. ●● Use as a remediation tool for at-risk students in a pharmacology course. ●● Assign modules related to body systems and disorders being studied in other courses. © 2012 Assessment Technologies Institute®, LLC 5 Pharmacology Made Easy® 2.0 ●● ●● ●● Arrange with learning lab personnel for the time and equipment necessary to practice administration of selected drugs. Showcase a selected drug or drug category during a clinical post-conference. Use the “Pharmacology Made Easy 2.0 Content Outline” to assign drugs for review in each course throughout the curriculum. Examples of Student Learning Activities ●● Review categories of drugs prescribed to assigned patients prior to giving drugs during patient care. ●● Print off drug tables as a quick reference guide. ●● Prepare for patient care by reviewing the safety alerts for safety warnings. ●● Remediate drug administration following an unsuccessful lab demonstration. ●● ●● Review modules, and take module tests prior to taking ATI Pharmacology and Comprehensive Predictor Assessments. Review modules, and take module tests prior to taking the NCLEX and other certification exams. Recommended Time Spent ●● ●● Refer to the Pharmacology Made Easy 2.0 Module Outline to determine the recommended amount of time for a student to spend on each module. Completing an assessment at the end of a module will require an additional 30 to 45 minutes. Product Support At ATI, we pride ourselves on timely and effective support to meet your needs. Please contact us at 800-667-7531 if you need assistance with this product. © 2012 Assessment Technologies Institute®, LLC 6 Pharmacology Made Easy® 2.0 Technical Requirements ●● ●● For optimal testing experience, we recommend a wired network connection. Direct links to downloads for starred (*) programs are provided in the bottom right-hand corner of the ATI Student/Faculty Home Page under “Technical Requirements.” ●● Silverlight 4 or higher* ●● Adobe Acrobat Reader X or higher* ●● Adobe Flash Player 11 or higher* ●● Windows XP, Vista, or 7 ●● ●● ◯◯ Internet Explorer 8 or higher; 9.0 recommended* ◯◯ Mozilla Firefox 14 or higher* Mac OS X 10.5 (Leopard) or higher ◯◯ Mozilla Firefox 14 or higher* ◯◯ Safari 5 or higher* Session time-out counter ◯◯ Your browser must allow status bar updates via script for a session time-out counter to be visible. © 2012 Assessment Technologies Institute®, LLC 7 Pharmacology Made Easy® 2.0 Pharmacology Made Easy 2.0 Module Outline Pharmacology Made Easy 2.0 Modules Introduction (1 hour) Neurological System (2 Parts) (3 hours) Musculoskeletal System (2 hours) Respiratory System (1½ hours) Cardiovascular System (4 hours) Hematologic System (2 hours) Gastrointestinal System (2 hours) Reproductive and Genitourinary System (2½ hours) Endocrine System (2½ hours) Immune System (2½ hours) Pain and Inflammation (3½ hours) Infection (1½ hours) © 2012 Assessment Technologies Institute®, LLC Drills and Tests ●● ●● ●● ●● ●● ●● ●● ●● ●● ●● ●● ●● ●● ●● ●● ●● ●● ●● ●● ●● ●● ●● ●● ●● 10-item drills 25-item test 20-item drills 50-item test 10-item drills 25-item test 10-item drills 25-item test 10-item drills 25-item test 10-item drills 25-item test 10-item drills 25-item test 10-item drills 25-item test 10-item drills 25-item test 10-item drills 25-item test 10-item drills 25-item test 10-item drills 25-item test 8 Pharmacology Made Easy® 2.0 Pharmacology Made Easy 2.0 Content Outline Module 1 – Introduction to Pharmacology ●● Introduction ●● Drug categories ●● Generic vs. trade or brand name ●● Prescription vs. nonprescription ●● Pharmaceutics ●● Pharmacokinetics ●● Pharmacodynamics ●● Expected pharmacological action and therapeutic uses ●● Side and adverse effects ●● Tolerance, cumulative effects, and toxicity ●● Precautions and contraindications ●● Drug-drug and drug-food interactions ●● Drug therapy across the lifespan ●● Patient instructions ●● Summary ●● Drills Module 2 – Neurological System (Part 1) ●● Introduction – definitions, A&P, common disorders ●● Central nervous system depressants ◯◯ Drug therapy for sleep disorders ■■ Benzodiazepine – temazepam (Restoril) ■■ Non-benzodiazepine – zolpidem (Ambien) ◯◯ Drug therapy for muscle spasms ■■ Centrally acting muscle relaxants – baclofen (Lioresal) ■■ Peripherally acting muscle relaxants – dantrolene (Dantrium) ◯◯ Drug therapy for seizure disorders ■■ Hydantoins – phenytoin (Dilantin) ■■ Iminostilbenes – carbamazepine (Tegretol) ■■ Valproic acid – valproic acid (Depakote, Depacon, Depakene) ■■ Other new drugs for seizure disorders ◯◯ Drug therapy that supports anesthesia ■■ Local anesthesia – lidocaine (Xylocaine) ■■ General anesthesia/barbiturates – sodium thiopental (Pentothal) ■■ General anesthesia/benzodiazepine – midazolam (Versed) ■■ General anesthesia/opioid – fentanyl (Sublimaze) © 2012 Assessment Technologies Institute®, LLC 9 Pharmacology Made Easy® 2.0 ●● ●● ●● ●● ●● CNS stimulants ◯◯ Drug therapy for ADHD and narcolepsy ■■ Amphetamines – amphetamine and dextroamphetamine sulfate (Adderall) ■■ Methylphenidate – methylphenidate (Ritalin, Concerta) ■■ Non-amphetamine – modafinil (Provigil) Chemical support of neuronal function ◯◯ Drug therapy for Parkinson’s disease ■■ Dopamine-replacement drugs – levodopa (Dopar, Larodopa) ■■ Direct-acting dopamine receptor agonists – pramipexole (Mirapex) ■■ Indirect-acting dopamine receptor agonists/MAOs – selegiline (Eldepryl, Zelapar ODT) ◯◯ Drug therapy for Alzheimer’s disease ■■ Cholinesterase inhibitors – donepezil (Aricept, Aricept ODT) ■■ NMDA receptor antagonist – memantine (Namenda) ◯◯ Drug that treat multiple sclerosis ■■ Immunomodulators – Interferon beta-1a (Avonex, Rebif), Interferon beta 1b (Betaseron) ◯◯ Drug that treat migraine headaches ■■ Serotonin agonists – sumatriptan (Imitrex) Summary Drills Case study Module 2 – Neurological System (Part 2) ●● Introduction – definitions, A&P, common disorders ●● Psychotherapeutic drugs ◯◯ Drug therapy for anxiety disorders ■■ Benzodiazepines – diazepam (Valium), alprazolam (Xanax) ■■ Non-benzodiazepines – buspirone (BuSpar) ◯◯ Drug therapy for depression ■■ Tricyclic antidepressants – amitriptyline (Elavil) ■■ SSRIs – fluoxetine (Prozac) ■■ SNRIs – venlafaxine (Effexor) ■■ MAOIs – phenelzine (Nardil) ■■ Atypical antidepressants – bupropion HCL (Wellbutrin) ◯◯ Drug therapy for bipolar disorder ■■ Lithium – lithium carbonate (Eskalith, Lithobid) ■■ Antiepileptic drugs (AED) – valproic acid (Depakote) ◯◯ Drug therapy for schizophrenia ■■ Conventional antipsychotics – chlorpromazine (Thorazine) ■■ Atypical antipsychotics – risperidone (Risperdal) © 2012 Assessment Technologies Institute®, LLC 10 Pharmacology Made Easy® 2.0 ●● ●● ●● ●● Autonomic nervous system drugs ◯◯ Drug therapy for glaucoma ■■ Beta adrenergic blocker – betaxolol (Betoptic), timolol (Timoptic) ■■ Cholinergic agonists – pilocarpine (Pilocar, Isopto Carpine) ■■ Cholinesterase inhibitors – echothiophate (Phospholine Iodide) Summary Drills Case study Module 3 – Musculoskeletal System ●● Introduction – definitions, A&P, common disorders ●● Drug therapy for rheumatoid arthritis ◯◯ DMARD I – methotrexate (Rheumatrex) ◯◯ DMARD II – etanercept (Enbrel) ●● Drug therapy for osteoporosis ◯◯ SERMs – raloxifene (Evista) ◯◯ Bisphosphonates – alendronate (Fosamax) ◯◯ Calcitonin – calcitonin-salmon (Calcimar, Miacalcin) ◯◯ Calcium supplements – calcium citrate (Citracal), calcium carbonate (Tums) ●● Drug therapy for myasthenia gravis ◯◯ Cholinesterase inhibitors – neostigmine (Prostigmin), pyridostigmine (Mestinon) ●● Drugs with neuromuscular blocking effects ◯◯ Neuromuscular blocking agents – succinylcholine (Anectine) ●● Summary ●● Drills ●● Case study Module 4 – Respiratory System ●● Introduction – definitions, A&P, common disorders ●● Drug therapy for airflow disorders ◯◯ Beta2-adrenergic agonists – albuterol (Proventil, Ventolin) ◯◯ Inhaled anticholinergics – ipratropium (Atrovent, Atrovent HFA) ◯◯ Methylxanthines – theophylline (Theo-24, Theolair, Theochron) ◯◯ Glucocorticoids ■■ Oral – prednisone (Deltasone) ■■ Inhalation – beclomethasone dipropionate (QVAR) ■■ Nasal – beclomethasone (Beconase AQ) ◯◯ Mast cell stabilizers – cromolyn (Intal) ◯◯ Leukotriene modifiers – montelukast (Singulair) © 2012 Assessment Technologies Institute®, LLC 11 Pharmacology Made Easy® 2.0 ●● ●● ●● ●● ●● Drug therapy for upper respiratory disorders – allergic rhinitis ◯◯ H1-receptor antagonists ■■ Sedating antihistamines – diphenhydramine (Benadryl) ■■ Nonsedating antihistamines – cetirizine (Zyrtec) ◯◯ Sympathomimetics ■■ Decongestants – phenylephrine (Neo-Synephrine) Drug therapy for upper respiratory disorders – cough ◯◯ Antitussives ■■ Opioid – codeine ■■ Nonopioid – dextromethorphan (Benylin) ◯◯ Expectorants – guaifenesin (Mucinex, Humibid) ◯◯ Mucolytics – acetylcysteine (Mucomyst) Summary Drills Case study Module 5 – The Cardiovascular System ●● Introduction ●● Drug therapy for hypertension ◯◯ RAAS Suppressants ■■ ACE inhibitors – captopril (Capoten) ■■ ARBs – losartan (Cozaar) ■■ Aldosterone antagonists – eplerenone (Inspra) ■■ Direct renin inhibitors – aliskiren (Tekturna) ◯◯ Calcium channel blockers – nifedipine (Adalat, Procardia) ◯◯ Sympatholytics ■■ Alpha1 adrenergic blockers – doxazosin (Cardura) ■■ Beta adrenergic blockers – atenolol (Tenormin), metoprolol (Lopressor) ■■ Adrenergic neuron blockers – reserpine (Serpalan, Reserpine) ■■ Centrally acting alpha2 agonists – clonidine (Catapres) ■■ Alpha/beta blockers – carvedilol (Coreg) ◯◯ Direct acting vasodilators – hydralazine (Apresoline) ●● Drug therapy for heart failure ◯◯ Diuretics ■■ Thiazide diuretics – hydrochlorothiazide (HydroDIURIL) ■■ Loop diuretics – furosemide (Lasix) ■■ Potassium-sparing diuretics – spironolactone (Aldactone) ◯◯ Cardiac glycosides – digoxin (Lanoxin) ◯◯ Sympathomimetics – dobutamine (Dobutrex) ◯◯ Phosphodiesterase inhibitors – milrinone (Primacor) © 2012 Assessment Technologies Institute®, LLC 12 Pharmacology Made Easy® 2.0 ●● ●● ●● ●● ●● Drug therapy for coronary heart disease ◯◯ Antilipemic ■■ HMG-CoA reductase inhibitors (statins) – simvastatin (Zocor) ■■ Fibrates – gemfibrozil (Lopid) ◯◯ Antianginals ■■ Nitrates – nitroglycerin (Nitrostat, Nitro-Dur, Nitro-Bid), isosorbide (Isordil, Ismo) Drug therapy for cardiac dysrhythmias ◯◯ Class I/sodium channel blockers ■■ Class IA – quinidine, procainamide (Pronestyl) ■■ Class IB – lidocaine (Xylocaine) ■■ Class IC – flecainide (Tambocor) ◯◯ Class II/beta adrenergic blockers – propranolol (Inderal) ◯◯ Class III/potassium channel blockers – amiodarone (Cordarone) ◯◯ Class IV/calcium channel blockers – verapamil (Calan) Summary Drills Case study Module 6 – The Hematologic System ●● Introduction – definitions, A&P, common disorders ●● Drug therapy for anemia ◯◯ Iron deficiency anemia – iron freparations – ferrous sulfate (Feosol), iron dextran (INFeD) ◯◯ Pernicious anemia – vitamin B12, cyanocobalamin (Nascobal, Cyanoject) ◯◯ Megaloblastic (macrocytic) anemia – folic acid (Folacin) ●● Drug therapy for bleeding disorders ◯◯ Hemophilia ■■ Factor VIII – plasma-derived (Hemofil-M) or recombinant factor VIII (Advate) ■■ Factor IX – plasma-derived (AlphaNine SD) or recombinant factor IX (BeneFix) ■■ Desmopressin – desmopressin (DDAVP, Stimate) ●● Drug therapy to prevent and dissolve thrombi ◯◯ Anticoagulants ■■ Factor Xa and thrombin inhibitor – heparin ■■ Factor Xa inhibitor – enoxaparin (Lovenox) ■■ Vitamin K inhibitor – warfarin (Coumadin) ◯◯ Antiplatelets ■■ Salicylics – aspirin (Ecotrin) ■■ ADP Inhibitors – clopidogrel (Plavix) ◯◯ Thrombolytics – alteplase (Activase) © 2012 Assessment Technologies Institute®, LLC 13 Pharmacology Made Easy® 2.0 ●● ●● ●● ●● Drug therapy the supports hematopoiesis ◯◯ Erythropoietic growth factor – epoetin alpha (Epogen, Procrit) ◯◯ Leukopoietic growth factor – filgrastim (Neupogen) ◯◯ Thrombopoietic growth factors – oprelvekin (Neumega) Summary Drills Case study Module 7 – The Gastrointestinal System ●● Introduction – definitions, A&P, common disorders ●● Drug therapy for peptic ulcers ◯◯ Histamine2-receptor antagonists – ranitidine hydrochloride (Zantac) ◯◯ Proton pump inhibitors – omeprazole (Prilosec) ◯◯ Mucosal protectant – sucralfate (Carafate) ◯◯ Antacids – aluminum hydroxide (Amphojel) ◯◯ Prostaglandin E analog – misoprostol (Cytotec) ◯◯ Antibiotics – amoxicillin (Amoxil), metronidazole (Flagyl), tetracycline (Sumycin) ●● Drug therapy for nausea ◯◯ Serotonin antagonists – ondansetron (Zofran) ◯◯ Dopamine antagonists – prochlorperazine (Compazine) ◯◯ Antihistamines – dimenhydrinate (Dramamine) ◯◯ Prokinetic – metoclopramide (Reglan) ●● Drug therapy for constipation ◯◯ Fiber supplements – psyllium (Metamucil) ◯◯ Stool softeners – docusate sodium (Colace), docusate sodium and senna (Peri-Colace) ◯◯ Stimulant laxatives – bisacodyl (Dulcolax) ●● Drug therapy for diarrhea ◯◯ Opioids – diphenoxylate and atropine (Lomotil), loperamide (Imodium) ●● Drug therapy for irritable bowel syndrome (IBS) ◯◯ 5-HT3 serotonin receptor blocker – alosetron (Lotronex) ◯◯ Selective chloride channel activator – lubiprostone (Amitiza) ●● Drug therapy for inflammatory bowel disease ◯◯ 5-aminosalicylates – sulfasalazine (Azulfidine) ◯◯ Immunosuppressants – azathioprine (Imuran) ●● Summary ●● Drills ●● Case study © 2012 Assessment Technologies Institute®, LLC 14 Pharmacology Made Easy® 2.0 Module 8 – Reproductive and Genitourinary Systems ●● Introduction – definitions, A&P, common disorders ●● Female reproductive drugs ◯◯ Estrogen and progesterone hormones ■■ Drug therapy for contraception and premenstrual syndrome (PMS) □□ Oral contraceptives – ethinyl estradiol and drospirenone (Yasmin) ■■ Drug therapy for menopause □□ Estrogen HRT ▲▲ Oral – conjugated equine estrogen (Premarin) ▲▲ Transdermal – estradiol (Estraderm) ▲▲ Intravaginal – estradiol (Vagifem, Estrace Vaginal Cream) □□ Estrogen and progesterone HRT ▲▲ Oral – conjugated estrogen and medroxyprogesterone acetate (Prempro) ▲▲ Transdermal – estradiol and norethindrone acetate transdermal system (CombiPatch) ■■ Drug therapy for endometrial hyperplasia and endometriosis □□ GnRH agonist – leuprolide (Lupron, Lupron Depot) □□ Progesterone – medroxyprogesterone acetate (Provera) ◯◯ Ovulation-related hormones ■■ Drug therapy for infertility □□ LH and FSH stimulant – clomiphene (Clomid) □□ Ovulation stimulant – hCG (Choron 10) □□ Hyperprolactinemia inhibitor – cabergoline (Dostinex) ◯◯ Oxytocics ■■ Drug therapy that induces uterine contractions □□ Oxytocin – oxytocin (Pitocin) □□ Ergot alkaloids – methylergonovine (Methergine) □□ Synthetic prostaglandin – dinoprostone (Cervidil) ■■ Drug therapy that stops uterine contractions □□ Beta2-adrenergic agonists – terbutaline (Brethine) ●● Male reproductive drugs ◯◯ Testosterone hormone ■■ Drug therapy for replacement of androgens □□ Testosterone – testosterone (Androderm, Delatestryl) ■■ Drug therapy for benign prostatic hypertrophy and outflow disorders □□ 5-alpha reductase inhibitor – finasteride (Propecia, Proscar) □□ Alpha-adrenergic receptor antagonists – tamsulosin (Flomax) © 2012 Assessment Technologies Institute®, LLC 15 Pharmacology Made Easy® 2.0 Drug therapy for erectile dysfunction □□ PDE5 inhibitor – sildenafil (Viagra) Urinary tract drugs ◯◯ Drug therapy for urinary incontinence/over-active bladder ■■ Anticholinergics – oxybutynin chloride (Ditropan) ◯◯ Drug therapy for urinary retention ■■ Cholinergics – bethanechol (Urecholine) Summary Drills Case study ■■ ●● ●● ●● ●● Module 9 – The Endocrine System ●● Introduction – definitions, A&P, common disorders ●● Drug therapy for diabetes mellitus ◯◯ Oral hypoglycemics ■■ Sulfonylureas – glipizine (Glucotrol) ■■ Meglitinides – repaglinide (Prandin) ■■ Biguanides – metformin (Glucophage) ■■ Thiazolidinediones – rosiglitazone (Avandia) ■■ Alpha-glucosidase inhibitors – acarbose (Precose) ■■ Gliptins – sitagliptin (Januvia) ◯◯ Injectable hypoglycemics ■■ Insulin – lispro (Humalog), Regular (Humulin R), NPH (Humulin N), insulin glargine (Lantus) ■■ Amylin mimetics – pramlintide (Symlin) ■■ Incretin mimetics – exenatide (Byetta) ◯◯ Hyperglycemics – glucagon (GlucaGen) ●● Drug therapy for thyroid disorders ◯◯ Thyroid replacements – levothyroxine (Synthroid) ◯◯ Antithyroid drugs ■■ Propylthiouracil – propylthiouracil (PTU) ■■ Radioactive iodine – iodine-131 (131I, Iodotope) ●● Drug therapy for hypothalamic disorders ◯◯ Growth hormone – somatropin (Genotropin, Nutropin, Humatrope, Serostim) ◯◯ Antidiuretic hormone – desmopressin (DDAVP, Stimate, Minirin ) ●● Drug therapy for adrenal disorders ◯◯ Glucocorticoids – hydrocortisone (Hydrocortone, Solu-Cortef) ◯◯ Mineralocorticoids – fludrocortisone (Florinef) ●● Summary ●● Drills ●● Case study © 2012 Assessment Technologies Institute®, LLC 16 Pharmacology Made Easy® 2.0 Module 10 – The Immune System ●● Introduction – definitions, A&P, common disorders ●● Drug therapy to prevent disease ◯◯ Childhood vaccines ◯◯ Adult and older adult vaccines ●● Drug therapy for cancer ◯◯ Cytotoxic drugs ■■ Antimetabolites □□ Folic acid analog – methotrexate (Rheumatrex) □□ Pyrimidine analog – cytarabine (Cytosar-U, DepoCyt) □□ Purine analogs – mercaptopurine (Purinethol) ■■ Alkylating agents □□ Nitrogen mustards – cyclophosphamide (Cytoxan) □□ Nitrosoureas – carmustine (BiCNU) ■■ Platinum compounds – cisplatin (Platinol-AQ) ■■ Antitumor antibiotics □□ Anthracyclines – doxorubicin (Adriamycin, Doxil) ■■ Antimitotics □□ Vinca alkaloid – vincristine (Oncovin) □□ Taxanes – paclitaxel (Taxol) ■■ Topoisomerase inhibitors – topotecan (Hycamtin) ◯◯ Hormonal agents ■■ Gonadotropin-releasing hormone agonists – leuprolide (Lupron, Lupron Depot) ■■ Androgen receptor blockers – flutamide (Eulexin) ■■ Estrogen receptor blockers – tamoxifen (Nolvadex) ■■ Aromatase inhibitors – anastrozole (Arimidex) ■■ Monoclonal antibody – trastuzumab (Herceptin) ◯◯ Biologic response modifiers ■■ Interferon – interferon alfa-2a (Roferon-A), interferon alfa-2b (Intron A) ◯◯ Targeted antineoplastic drugs ■■ BCR-ABL tyrosine kinase inhibitor – imatinib (Gleevec) ●● Drug therapy for HIV ◯◯ Antiretrovirals ■■ Viral entry blockers □□ Entry and infusion inhibitors – enfuvirtide (Fuzeon) □□ CCR5 antagonist – maraviroc (Selzentry) ■■ Enzyme inhibitors □□ Nucleoside reverse transcriptase inhibitors (NRTIs) – zidovudine (Retrovir) □□ Non-nucleoside reverse transcriptase inhibitors (NNRTIs) – delavirdine (Rescriptor) © 2012 Assessment Technologies Institute®, LLC 17 Pharmacology Made Easy® 2.0 □□ □□ ●● ●● ●● Integrase inhibitor – raltegravir (Isentress) Protease inhibitors (PIs) – ritonavir (Norvir) Summary Drills Case study Module 11 – Pain & Inflammation ●● Introduction – definitions, A&P, common disorders ●● Drug therapy for pain ◯◯ Nonopioid analgesics ■■ NSAIDs (COX-1 and COX-2 inhibitors) – aspirin, ibuprofen (Advil, Motrin) ■■ NSAIDs (COX-2 inhibitor) – celecoxib (Celebrex) ■■ Acetaminophen – acetaminophen (Tylenol) ■■ Centrally acting nonopiods – tramadol (Ultram) ◯◯ Opioid analgesics ■■ Opioid agonists – morphine ■■ Opioid agonist-antagonists – butorphanol (Stadol), pentazocine (Talwin) ◯◯ Opioid antagonists – naloxone (Narcan) ●● Drug therapy for inflammation ◯◯ Uricosurics (fout) – allopurinol (Zyloprim) ◯◯ Glucocorticoids – prednisone (Deltasone) ●● Summary ●● Drills ●● Case study Module 12 – Infection ●● Introduction – definitions, A&P, common disorders ●● Drug therapy for bacterial infections ◯◯ Drugs that interfere with cell wall synthesis ■■ Penicillins – amoxicillin (Amoxil), amoxicillin and clavulanic acid (Augmentin) ■■ Cephalosporins – cephalexin (Keflex) ■■ Monobactams – aztreonam (Azactam) ■■ Carbapenem – imipenem and cilastatin (Primaxin) ■■ Vancomycin – vancomycin (Vancocin) ◯◯ Antibiotics that inhibit protein synthesis ■■ Tetracyclines – tetracycline (Sumycin) ■■ Macrolides – erythromycin (E-Mycin) ■■ Aminoglycosides – gentamicin (Garamycin) ◯◯ Drugs that inhibit DNA replication or cell division ■■ Fluoroquinolones – ciprofloxacin (Cipro) © 2012 Assessment Technologies Institute®, LLC 18 Pharmacology Made Easy® 2.0 ●● ●● ●● ●● ●● ●● ●● ●● Drug therapy for urinary tract and other bacterial infections ◯◯ Drugs that inhibit folic acid synthesis ■■ Sulfonamides – trimethoprim and sulfamethoxazole (Bactrim, Septra) ■■ Urinary tract antiseptics – nitrofurantoin (Macrodantin) Drug therapy for tuberculosis ◯◯ Antimicobacterials – isoniazid (INH, Nydrazid-IM form), rifampin (Rifadin) Drug therapy for parasitic infections ◯◯ Antiparasitics – metronidazole (Flagyl), chloroquine (Aralen) Drug therapy for fungal infections ◯◯ Antifungals ■■ Polyene antibiotics – amphotericin B (Fungizone) ■■ Azoles – ketoconazole (Nizoral) Drug therapy for viral infections ◯◯ Antivirals – acyclovir (Zovirax) Summary Drills Case study © 2012 Assessment Technologies Institute®, LLC 19 Pharmacology Made Easy® 2.0 References Kozier, B., Erb, G., Berman, A. J., & Burke, K. (2011). Fundamentals of nursing (9th ed.). Upper Saddle River, NJ: Prentice-Hall. Lehne, R. A. (2010). Pharmacology for nursing care (7th ed.). St. Louis, MO: Saunders Elsevier. Lilley, L. L., Collins, S. R., Harringston, S., Snyder, J. S. (2011). Pharmacology and the nursing process (6th ed.). St. Louis, MO: Mosby Elsevier. Potter, P. A., & Perry, A. G. (2009). Fundamentals of nursing (7th ed.). St. Louis, MO: Mosby Elsevier. Wilson, B. A., Shannon, M. T., & Shields, K. M. (2011). Pearson nurse’s drug guide. New York, NY: Pearson © 2012 Assessment Technologies Institute®, LLC 20