Michelle Hampson
Research Scientist
Department of Diagnostic Radiology, Yale University
1 Gilbert Street, TAC, N-121
P.O. Box 208042
New Haven, CT 06520-8042
tel: (203) 737-5994
e-mail: michelle.hampson@yale.edu
Current Research Interests
I am interested in the development and application of new functional imaging paradigms
that examine brain function at the systems level. In the last few years, I have been
studying the relationships between behavioural variables and the strengths of specific
brain connections in order to gain insight into the functional relevance of those
connections. In addition, I have been examining event-related brain activations using a
correlation-based alternative to conventional event-related protocols that does not require
knowledge regarding the time of occurrence of different events. I am interested in
continuing a research program focused on the application of these methods, and the
development of new imaging methods, to address questions in clinical and cognitive
neuroscience. One new area of particular interest is the development of biofeedback of
real-time fMRI data as both a clinical treatment for mental disorders and a tool for
investigating human brain function.
Research Experience
Yale University, Research Scientist of Diagnostic Radiology. Summer 2007 – present.
Investigating brain systems via studies of inter-regional correlations in functional
MR images and using biofeedback of real-time fMRI data to influence brain
function.
Yale University, Associate Research Scientist of Diagnostic Radiology. Summer 2002 –
Summer 2007. Investigating brain systems via studies of inter-regional
correlations in functional MR images.
Yale University, Department of Diagnostic Radiology and Child Study Center. Fall 1999
– Summer 2002. Postdoctoral fellow developing methods for examining
functional connectivity in the brain using functional imaging data.
Boston University, Department of Cognitive and Neural Systems. Spring 1996 - Fall
1999. Research fellow under supervision of Frank Guenther: used psychophysics
and computational modeling to investigate issues in speech.
Boston University, Department of Mathematics. Summer 1995. Developed computational
model of the leech swim circuit with Nancy Kopell.
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University of Alberta, Department of Computing Science. Summer 1992. Research
fellow working with Roderick Johnson: prepared system and wrote manual for
undergraduate computer engineering laboratories.
University of Alberta, Department of Computing Science. Summer 1991. Research
fellow working with Jim Hoover: designed graphical models of graph traversal
algorithms as learning tools for students of computational theory.
Education
Ph.D. Cognitive and Neural Systems. January 2000.
Boston University, Boston, Massachusetts.
B.Sc. Computing Science. May 1993.
University of Alberta, Edmonton, Alberta, Canada.
Articles
Hampson, M., Stoica, T., Saksa, J., Scheinost, D., Qiu, M., Bhawnani, J., Pittenger, C.,
Papademetris, X. 2011, Constable, R.T. 2011. Real-time fMRI biofeedback
targeting the orbitofrontal cortex for contamination anxiety, Journal of Visualized
Experiments, In press.
Hampson, M., Scheinost, D., Qiu, M., Bhawnani, J., Lacadie, C., Leckman, J.F.,
Constable, R.T., Papademetris, X. 2011. Biofeedback from the supplementary
motor area reduces functional connectivity to subcortical regions. Brain
Connectivity, 1(1): 91-8.
Hoffman, R.E., Pittman B., Constable R.T., Bhagwagar Z., Hampson M. 2011. Timecourse of regional brain activity accompanying auditory/verbal hallucinations in
schizophrenia. British Journal of Psychiatry, In press.
Hoffman, R.E., Fernandez T., Pittman B., Hampson M. 2011. Elevated functional
connectivity along a corticostriatal loop and the mechanism of auditory/verbal
hallucinations in patients with schizophrenia. Biological Psychiatry, 69: 407-14.
Mullen, K.M., Vohr, B.R., Katz, K.H., Schneider, K.C., Lacadie, C.M., Hampson, M.
Makuch, R.W., Reiss, A.R., Constable, R.T. 2011. Preterm birth results in
alterations in neural connectivity at age 16 years. NeuroImage, 54(4): 2563-70.
Lubsen, J., Vohr, B., Myers, E., Hampson, M., Lacadie, C., Schneider, K.C., Katz, K.H.,
Constable, R.T., Ment, L.R. 2011. Microstructural and functional connectivity in
the developing preterm brain. Seminars in Perinatology, 35(1): 34-43.
Hampson, M., Hoffman, R.E. 2010. Transcranial magnetic stimulation and connectivity
mapping: tools for studying the neural bases of brain disorders. Frontiers in
Systems Neuroscience, 4(40): 1-8.
Leckman, J.F., Bloch, M., Smith, M., Larabi, D., Hampson, M. 2010. Neurobiological
substrates of Tourette Syndrome. Journal of Child and Adolescent
Psychopharmacology, 20(4): 237-47.
Chepenik, L.G., Raffo, M., Hampson, M., Lacadie, C., Wang, F., Jones, M.M., Pittman,
B., Skudlarski, P., Blumberg, H.P. 2010. Low frequency temporal associations
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between ventral prefrontal cortex and amygdala activity in the resting state in
bipolar disorder. Psychiatry Research: Neuroimaging, 183(3): 207-10.
Myers, E.H., Hampson, M., Vohr, B., Lacadie, C., Frost, S.J., Pugh, K.R., Katz, K.H.,
Schneider, K.C., Makuch, R.W., Constable, R.T., Ment, L.R. 2010. Functional
connectivity to a right hemisphere language center in prematurely born
adolescents, NeuroImage, 51(4): 1445-52.
Hampson, M., Driesen, N.R., Roth, J., Gore, J.C., Constable, R.T. 2010. Functional
connectivity between task-positive and task-negative brain areas and its relation to
working memory performance. Magnetic Resonance Imaging, 28(8): 1051-7.
Biswal et al. 2010. Towards discovery science of human brain function. Proceedings of
the National Academy of Sciences, 107(10): 4734-9.
Gozzo, Y., Vohr, B., Lacadie, C., Hampson, M., Katz, K.H., Maller-Kesselman, J.,
Schneider, K.C., Peterson, B.S., Rajeevan, N., Makuch, R.W., Constable, R.T.,
Ment, L.R. 2009. Alterations in neural connectivity in preterm children at school
age. NeuroImage, 48(2):458-63.
Hampson, M., Tokoglu, F., King, R.A., Constable, R.T., Leckman, J.F. 2009. Brain
areas co-activating with motor cortex during chronic motor tics and intentional
movements. Biological Psychiatry, 65(7): 594-9.
Skudlarski, P., Jagannathan, K., Calhoun, V.D., Hampson, M., Skudlarska, B.A.,
Pearlson, G. 2008. Measuring brain connectivity: diffusion tensor imaging
validates resting state temporal correlations. NeuroImage, 43(3): 554-61
Hoffman, R.E., Anderson, A.W., Varanko, M., Gore, J.C., Coric, V., Hampson, M.
2008. Time course of regional brain activation associated with onset of
auditory/verbal hallucinations. British Journal of Psychiatry,193: 424-425.
Hoffman, R., Hampson, M. Wu, K., Anderson, A., Gore, J., Buchanan, R.J., Constable,
T. Hawkins, K., Sahay, N., Krystal, J.H., 2007. Probing the pathophysiology of
auditory hallucinations by combining functional magnetic resonance imaging and
transcranial magnetic stimulation. Cerebral Cortex, 17: 2733-2743.
Hampson, M., Driesen, N.R., Skudlarski, P., Gore, J.C., Constable, R.T. 2006. Brain
connectivity related to working memory performance. The Journal of
Neuroscience, 26(51): 13338-13343.
Hampson, M., Tokoglu, F., Sun, Z. Schafer, R., Skudlarski, P., Gore, J.C., Constable,
R.T., 2006. Connectivity-behaviour analysis reveals that functional connectivity
between left BA39 and Broca’s area varies with reading ability. NeuroImage, 31:
513-519.
Hampson, M., Olson, I.R., Leung, H.C., Skudlarski, P., Gore, J.C. 2004. Changes in
functional connectivity of MT/v5 with visual motion input. NeuroReport, 15(8):
1315-9.
Hoffman, R.E., Hampson, M., Varanko, M., McGlashan T.H. 2004. Auditory
hallucinations, network connectivity, and schizophrenia (commentary).
Behavioral and Brain Sciences, 27: 860-1.
Hampson, M., Peterson, B., Skudlarski, P., Gatenby, C. and Gore, J. 2002. Detection of
functional connectivity using temporal correlations in MR images. Human Brain
Mapping, 15: 247-262.
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Guenther, F., Hampson, M., and Johnson, D. 1998. A theoretical investigation of
reference frames for the planning of speech movements. Psychological Review,
105(4), 611-633.
Book Chapters
Hampson, M., Shen, X., Constable, R.T. Functional connectivity MR imaging. In
Functional Neuroradiology: Principles and Clinical Applications, Eds. Faro, S.H.,
Mohamed, F.B., In press.
Leckman, J.F., Bloch, M.H., Hampson, M., King, R.A. Neurobiological substrates of tic
disorders. In Pediatric Psychopharmacology, Second Edition. Editors: Martin, A.,
Scahill, L. and Kratochvil, C.J. Published in 2011 by Oxford University Press,
Inc.
Hampson, M. Relating variations in network connectivity to cognitive function. In
Analysis and Function of Large-scale Brain Networks. Published in 2011 by
Society for Neuroscience.
Teaching Experience
Boston University, Department of Cognitive and Neural Systems. Fall 1995. Presented
seminars on mathematical and computer topics.
University of Alberta, Department of Computing Science. Fall 1991 - Fall 1992.
Teaching fellow responsible for marking and giving weekly hour seminars for
introductory logic courses.
University of Alberta, Department of Computing Science. Summer 1992. Teaching
fellow responsible for preparing computer engineering lab and manual.
Awards
National Institute of Mental Health, 2010, R21 Award (R21MH090384), Principal
Investigator on project titled: Biofeedback of real-time fMRI to control activity in
the orbitofrontal cortex.
DANA Foundation, Program in Brain and Immuno-imaging, 2009. Principal Investigator
on project titled: Biofeedback of activity in the supplementary motor area to
reduce tics in Tourette Syndrome.
Tourette Syndrome Association, Inc. 2003. Principal Investigator on project titled: FMRI
study of the regional brain activations associated with motor tics in Tourette's
Syndrome.
National Science Foundation. 2001. Principal Investigator for BCS grant #0121926,
titled: Evaluating the efficacy of a new functional imaging protocol for obtaining
data on functional connectivity. Project involved examining relationships between
behavioural measures and functional connections in the brain.
National Institute of Neurological Disorders and Stroke. 2001. Fellowship in
Neuroimaging Sciences Training Program, Yale University.
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National Institute of Mental Health. 1999. Fellowship in Training Program in Childhood
Neuropsychiatric Disorders, Yale University.
Presidential University Graduate Fellowship. Boston University, 1994.
Natural Sciences and Engineering Research Council of Canada. PGS 1 Scholarship for
full graduate education (declined) 1993.
Invited presentations
Resting State Functional Connectivity, 3rd biennial meeting, (www.restingstate.com),
September, 2012, Magdeburg, Germany.
Society for Neuroscience Annual Meeting, Short Course titled “Analysis and Function of
Large-Scale Brain Networks”, November, 2010, San Diego, USA.
Resting State Functional Connectivity, 2nd biennial meeting, September, 2010,
Milwaukee, USA.
International School on Magnetic Resonance and Brain Function. VII Workshop: Brain
Function Investigation by Magnetic Resonance, Electrophysiology, and
Molecular Imaging, Erice, Italy, May 2009.
Workshop on Connectivity in the Resting Brain, Magdeburg, Germany, December 2008.
Sixth International Workshop on Brain Connectivity, Barcelona, Spain, May 2007.
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