Determined of Current Antimicrobial Sensitively for Treatment of Urinary Tract Infection Caused by E.coli in kermanshah Reference Laboratory patients Introdaction and aims: Urinary Tract Infection (UTI) is one of the most common infection during human life , more than 85% of UTIs ocurr by E.coli. Increasing antibiotics resistance in pathogenic bacterial genealogy of UTI , specially in E.coli is of the substantial problem in therapy . Material and method: This study was on 326 positive urine culture in patients and were evaluated based on disk diffusion method according to antibiotic resistance pattern to NCCLS table. In this study with use 14 current antimicrobial for treatment in UTI such as , AM , AMX, SXT, GM, NA, FM ,CAZ, CP, NOR, CT, CRO,CN, CTX, CFM . Results: 326 urine sample( 272 women 54 men), The most effective antibiotic was FM(79.44%) ,CT( 60.12%), CAZ(48.77%), NA(47.85%), GM(42.94%) and there after to antibiotics CP, NOR ,CTX, SXT, CRO, CFM, CN,AMX & AM respectively most sensitivity was observed. Discution and conclusion:comparing the results of resistance pattern of this study with other countries, is seems irregular use of antibiotics is the increased antibiomicrobial resistance. Key words: UTI, E.coli, resistance and sensitive antibiotics